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1.
Clin Cancer Res ; 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-32998962

RESUMO

PURPOSE: Report results of the phase Ib dose escalation/expansion study of triplet therapy with cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor (ribociclib), mTOR inhibitor (everolimus), and endocrine therapy (exemestane). METHODS: Postmenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), pre-treated, advanced breast cancer (ABC) were enrolled. The primary objective of the dose escalation phase was to estimate the maximum tolerated dose and recommended phase II dose (RP2D) of triplet therapy through evaluation of the incidence of dose-limiting toxicities. Safety, tolerability, and efficacy of the RP2D were evaluated in the dose expansion phase in patients naive or refractory to CDK4/6 inhibitor therapy. RESULTS: Patients (N=116) received triplet therapy (n=83 in the dose escalation phase; n=33 in the dose expansion phase). A dose-dependent drug-drug interaction was observed for everolimus, with exposure increasing 2- to 4-fold in the presence of ribociclib. The RP2D was determined to be ribociclib 300 mg once daily (QD), 3 weeks on/1 week off in a 4-week cycle, plus everolimus 2.5 mg QD, plus exemestane 25 mg QD taken with food. The safety profile was consistent with the known profiles of the combination partners, and preliminary evidence of antitumor activity was observed. Higher ESR1 gene expression trended with better treatment response to triplet therapy; higher gene expression of MAPK pathway genes trended with worse treatment response. CONCLUSION: Triplet therapy with endocrine therapy and mTOR and CDK4/6 inhibition provides clinical benefit and an acceptable safety profile in previously treated postmenopausal women with HR+, HER2- ABC.

2.
IEEE Trans Cybern ; PP2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33001826

RESUMO

In this technical correspondence, a multilayer formation (MLF) control problem is considered and solved by a unified framework. The agents in each layer present a sort of hierarchical distinction: receive information from former layers, communicate inside the current layer, and send information to subsequent layers. With an arbitrary number of layers, we extend the previous result from undirected graphs to directed ones. The proposed controller achieves MLF without using the distributed estimators and the acceleration information. This removes the induced discontinuities and alleviates the system complexity. It is then proved that the closed-loop errors are semiglobally uniformly ultimately bounded. Simulations are presented to illustrate the effectiveness of this approach.

3.
Clin Nutr ; 2020 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-33008652

RESUMO

BACKGROUND & AIMS: Our previous study found that platelet counts were positively associated with body fat percentage in human. In the present study, we conducted a reverse translational study to explore the role of platelets in modulating pre-adipocyte proliferation in mice. METHODS: Mouse pre-adipocyte cell line (3T3-L1) and human pre-adipocytes harvested from female subcutaneous fat were used. Pre-adipocytes were co-cultured with platelets or platelet releasate, which were isolated from mice or humans. The cell viability and proliferative ability of the pre-adipocytes were examined by MTT and flow cytometry assays. Western blotting analysis was used to determine the phosphorylation levels of proteins in the mTOR pathway. RESULTS: The number of platelets in the adipose tissues from obese mice was significantly higher than that from lean mice. Platelets and collagen-activated platelet releasate stimulated the proliferation of human pre-adipocytes and 3T3-L1 cells in vitro. Besides, platelets from obese mice were more potent in stimulating pre-adipocyte proliferation than those from lean control mice. Mechanistically, platelets enhanced pre-adipocyte proliferation through the acceleration of cell cycle progression from G0/G1 to S phase cell cycle progression. At the molecular level, platelets promoted pre-adipocyte proliferation through mTOR pathway-mediated upregulation of cyclin D1 expression. CONCLUSION: In conclusion, platelets and platelet releasate play an important role in the proliferation of pre-adipocytes. Our study may provide new clues and the molecular mechanism of the causal pathways between platelets and body fat to explain the finding we observed in population study.

4.
Ann Hum Genet ; 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33026665

RESUMO

OBJECTIVE: To assess the experience on prenatal diagnosis of Miller-Dieker syndrome (MDS) to further delineate the fetal presentation of this syndrome. METHODS: This was a retrospective study. Fetal MDS was diagnosed prenatally by chromosomal microarray (CMA). Clinical data were reviewed for these cases, including maternal characteristics, indications for prenatal diagnosis, sonographic findings, CMA results, and pregnancy outcomes. RESULTS: Four cases were diagnosis as MDS by CMA. The most common sonographic features were ventriculomegaly (3/4) and polyhydramnios (2/4). Deletion sizes ranged from 1.5 to 5.4 Mb. All microdeletions were located at the MDS critical region and showed haploinsufficiency of the YWHAE, CRK, and PAFAH1B1. All patients chose to terminate the pregnancy. Parental chromosome analysis were preformed in three cases and demonstrated that two cases were de novo and one case was caused by inherited derivative chromosomes from parental balanced translocations. CONCLUSION: The most common prenatal ultrasound findings of MDS were ventriculomegaly and polyhydramnios. CMA can improve diagnostic precision for detecting MDS.

5.
J Biotechnol ; 324: 91-98, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33010308

RESUMO

Enzymes, which provide more efficient and eco-friendly strategies for various functional molecules' construction than traditional chemo-catalysts, were utilized for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives. Reported herein is a trypsin-catalysed three- component Biginelli reaction of aldehyde, ß-ketoester and 2-amino benzothiazole in one pot, affording a streamlined pathway to diverse ring-fused pyrimidines. In addition to using commercially available aromatic aldehydes as substrates, acetaldehyde, the chemical liquid with rather low boiling point and difficult to handle above room temperature, is utilized to further extend the range of substrates. It was verified that most of the tested substrates exhibited satisfactory reactivity. In addition, several substrates indicated AIE (Aggregation-Induced Emission) property and have been investigated as potential biomarkers.

6.
Clin Interv Aging ; 15: 1809-1820, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33061331

RESUMO

Objective: Our study aimed to explore the association between trimethylamine N-oxide and frailty in older adults with cardiovascular disease. Patients and Methods: This cross-sectional study analyzed a total of 451 people aged 65 years or older who underwent comprehensive geriatric assessments. Frailty status was determined using a frailty index constructed with 48 variables according to the cumulative deficits model. Physical frailty and cognitive frailty were also assessed in detail. Fasting plasma TMAO was measured by mass spectrometry. Results: The proportion of frail subjects was 29.9% (135/451). Plasma TMAO levels were significantly higher in frail patients than in nonfrail individuals (4.04 [2.84-7.01] vs 3.21 [2.13-5.03] µM; p<0.001). Elevated plasma TMAO levels were independently associated with the likelihood of frailty (OR 2.12, 95% CI 1.01-4.38, p=0.046). Dose-response analysis revealed a linear association between the TMAO concentration and the OR for frailty. A 2-unit increase in TMAO was independently correlated with physical frailty (OR 1.23, 95% CI 1.08-1.41, p for trend 0.002) and cognitive frailty (OR 1.21, 95% CI 1.01-1.45, p for trend 0.04). Conclusion: Elevated circulating TMAO levels are independently associated with frailty among older adults with cardiovascular disease.

7.
J Appl Psychol ; 2020 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-33030924

RESUMO

Coronavirus disease 2019 (COVID-19) is a disruptive event devastating to the workplace and the global community. Drawing on terror management theory, we develop and test a model that explains how COVID-19-triggered mortality salience influences employees' state anxiety and their responses at and outside work. We conducted an experience sampling method study using employees from an information technology firm in China when COVID-19 was surging there and two experiments using employees from a variety of industries in the United States when it became a new epicenter of the global outbreak. Results from 3 studies largely supported our theoretical hypotheses. Specifically, our research showed that mortality salience concerning COVID-19 was positively related to employees' state anxiety (general anxiety in Study 1 and Study 2 and death-specific anxiety in Study 3). Our studies also found that servant leadership is particularly crucial in guiding employees with state anxiety associated with COVID-19 mortality salience to be engaged in their jobs and to contribute more to the broader community. Our findings offer timely, valuable implications for theory and practice. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

8.
Environ Pollut ; 268(Pt B): 115705, 2020 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-33035876

RESUMO

The exploitation of a new adsorbent with a high adsorption performance and recyclability is of great practical significance for the treatment of wastewater containing mercury ions. In this study, a novel membrane adsorbent was fabricated by blending MoS2 nanosheets into a PVDF polymer matrix (P-PVDF/MoS2) followed by non-solvent-induced phase conversion. This material was able to bind mercury ions and was not affected by the solution ionic strength, co-existing anions, or interfering heavy metal ions. The optimal pH range for mercury ion elimination was 4.5-6.0, and P-PVDF/MoS2 exhibited a maximum adsorption capacity of 578 mg g-1. The pseudo-second-order adsorption kinetics and Langmuir isotherm models best described the adsorption process. The adsorption mechanism was mainly monolayer chemisorption, for which the S groups were the major active sites. Furthermore, the membrane could be removed from the aqueous solution easily using tweezers, and the removal efficiency of mercury ions remained over 90% after ten cycles. This study suggests that the inexpensive and recyclable P-PVDF/MoS2 membranes can be used for the efficient removal of heavy metal ions from wastewater at a large scale.

9.
Allergy ; 2020 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-33040337

RESUMO

BACKGROUND: The missing asymptomatic COVID-19 infections have been overlooked because of the imperfect sensitivity of the nucleic acid testing (NAT). Globally understanding the humoral immunity in asymptomatic carriers will provide scientific knowledge for developing serological tests, improving early identification, and implementing more rational control strategies against the pandemic. MEASURE: Utilizing both NAT and commercial kits for serum IgM and IgG antibodies, we extensively screened 11,766 epidemiologically suspected individuals on enrollment and 63 asymptomatic individuals were detected and recruited. 63 healthy individuals and 51 mild patients without any preexisting conditions were set as controls. Serum IgM and IgG profiles were further probed using a SARS-CoV-2 proteome microarray and neutralizing antibody was detected by a pseudotyped virus neutralization assay system. The dynamics of antibodies were analyzed with exposure time or symptoms onset. RESULTS: A combination test of NAT and serological testing for IgM antibody with discovered 55.5% of the total of 63 asymptomatic infections, which significantly raises the detection sensitivity when compared with the NAT alone (19%). Serum proteome microarray analysis demonstrated that asymptomatics mainly produced IgM and IgG antibodies against S1 and N proteins out of 20 proteins of SARS-CoV-2. Different from strong and persistent N specific antibodies, S1 specific IgM responses, which evolved in asymptomatic individuals as early as the seventh day after exposure, peaked on days from 17d to 25d, and then disappeared in two months, might be used as an early diagnostic biomarker. 11.8% (6/51) mild patients and 38.1% (24/63) asymptomatic individuals did not produce neutralizing antibody. In particular, neutralizing antibody in asymptomatics gradually vanished in two months. CONCLUSION: Our findings might have important implications for the definition of asymptomatic COVID-19 infections, diagnosis, serological survey, public health and immunization strategies.

10.
J Appl Toxicol ; 2020 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-33079441

RESUMO

Refractory ceramic fibers (RCFs) are increasingly used as heating-insulated materials in various industries. However, toxicological and epidemiological studies focusing on the adverse effects of RCFs were still insufficient, particularly in China. We conducted a cross-sectional study to evaluate comprehensively the associations between occupational exposure to RCFs and respiratory health effects among Chinese workers. We measured and calculated cumulative RCFexposure levels of RCFs workers from the biggest RCFs factory in China. In total, 430 RCF-exposed workers and 121 controls were enrolled in this study. Physical examinations of the respiratory system were performed and serum levels of biomarkers including Clara cell protein 16 (CC16), surfactant protein D (SP-D), transforming growth factor ß1 (TGF-ß1), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were determined among all subjects. RCF exposure workers showed a higher prevalence rate of respiratory symptoms (cough: 11.9%) and lower levels of small airways function indices (V50 %: 82.71 ± 20.01, maximal mid expiratory flow (MMEF)%: 81.08 ± 19.56) compared with the control group (cough: 5.0%, V50 %: 90.64 ± 24.36, MMEF%: 88.83 ± 24.22). RCFs workers showed higher levels of TGF-ß1 (31.04 ng/mL) and 8-OHdG (130.72 ng/mL) and lower levels of CC16 (3.68 ng/mL) compared with the controls (TGF-ß1: 26.63 ng/mL, 8-OHdG: 106.86 ng/mL, CC16: 5.65 ng/mL). After adjusting for covariates, cumulative RCF exposure levels showed significant positive associations with the levels of TGF-ß1 and 8-OHdG and negative association with the level of CC16. Occupational RCF exposure could induce adverse respiratory health effects, including cough and small airways damage, which may correlate to the altered levels of lung damage markers (CC16 and TGF-ß1) and oxidative markers (8-OHdG).

11.
Artigo em Inglês | MEDLINE | ID: mdl-32870775

RESUMO

Significance: Wound dressings are frequently used for wound covering and healing. Ideal wound dressings should provide a moist environment for wounds and actively promote wound healing and skin recovery. The materials used as ideal wound dressings should possess specific properties, thus accelerating skin tissue regeneration process. Recent Advances: Bacterial cellulose (BC) is a natural polymer synthesized by some bacteria. As a kind of natural biopolymer, BC shows good biological activity, biodegradability, and biological adaptability. It has many unique physical, chemical, and biological properties, such as ultrafine nanofiber network, high crystallinity, high water absorption and retention capacity, and high tensile strength and elastic modulus. These excellent properties of BC have laid the foundation for its application as dressing in wound healing. Critical Issues: To optimize the biocompatibility and antimicrobial activity of BC, different methods including microbial fermentation, physical modification, chemical modification, and compound modification have been adopted to modify BC to ensure a better application in wound healing. BC-based wound dressings have been applied in infected wounds, acute traumatic injuries, burns, and diabetic wounds, showing remarkable therapeutic effects on promoting wound healing. Furthermore, there have been some commercial BC-based dressings and they have been utilized in clinical practice. Future Directions: Because of its excellent physicochemical characteristics and biological properties, BC shows high clinical value to be used as a wound dressing for skin tissue regeneration.

12.
Artigo em Inglês | MEDLINE | ID: mdl-32991278

RESUMO

Non-local low-rank tensor approximation has been developed as a state-of-the-art method for hyperspectral image (HSI) restoration, which includes the tasks of denoising, compressed HSI reconstruction and inpainting. Unfortunately, while its restoration performance benefits from more spectral bands, its runtime also substantially increases. In this paper, we claim that the HSI lies in a global spectral low-rank subspace, and the spectral subspaces of each full band patch group should lie in this global low-rank subspace. This motivates us to propose a unified paradigm combining the spatial and spectral properties for HSI restoration. The proposed paradigm enjoys performance superiority from the non-local spatial denoising and light computation complexity from the low-rank orthogonal basis exploration. An efficient alternating minimization algorithm with rank adaptation is developed. It is done by first solving a fidelity term-related problem for the update of a latent input image, and then learning a low-dimensional orthogonal basis and the related reduced image from the latent input image. Subsequently, non-local low-rank denoising is developed to refine the reduced image and orthogonal basis iteratively. Finally, the experiments on HSI denoising, compressed reconstruction, and inpainting tasks, with both simulated and real datasets, demonstrate its superiority with respect to state-of-the-art HSI restoration methods.

13.
J Matern Fetal Neonatal Med ; : 1-6, 2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32907415

RESUMO

OBJECTIVE: To compare prenatal and perinatal outcomes of twin pregnancies in which one twin the nuchal translucency (NT) was above the 95th percentile in dichorionic twins (DCT) and monochorionic twins (MCT). METHOD: In this retrospective study, 93 twin pregnancies (186 fetuses) in which one twin the NT was above the 95th percentile and the co-twin had normal NT were analyzed. Results of of G-banding and Chromosomal microarray (CMA), ultrasound findings and pregnancy outcomes were reviewed. RESULTS: Totally, 57 pregnancies (114 fetuses) were DCT and 36 pregnancies (72 fetuses) were MCT. Karyotyping and CMA results shown that clinically significant chromosomal abnormalities were found in 16 fetuses, including 13 aneuploidies, 2 chromosomal mosaic and 1 pathological Copy number variations (CNVs) (14 were DCT and 2 were MCT). Overall, the incidence of fetal chromosomal abnormalities was 12.3% (14/114) in DCT and 2.8%(2/72) in MCT (χ2 = 3.932, p = 0.047). Among the cases with normal prenatal diagnosis result, structural abnormalities were found in four fetuses (4.0%, 4/100) in DCT and two fetuses (2.9%, 2/70) in MCT (p > 0.999). There were one intrauterine fetal demises (IUFD) and two miscarry in DCT. One IUFD, three subsequently developed Twin-to-Twin Transfusion Syndrome (TTTS) and four developed selective intrauterine growth restriction (sIUGR) in MCT. Totally, the overall fetal survival rate was 85.1% (97/114) in DCT and 80.6% (58/72) in MCT (χ2 = 0.653, p = 0.419). CONCLUSION: Compared to MCT, the incidence of chromosomal abnormalities in DCT discordant for one fetus with NT above the 95th percentile was higher. The risk of structural abnormalities and the rate of fetal survival for both MCT and DCT was similar.

14.
World J Gastroenterol ; 26(31): 4680-4693, 2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32884225

RESUMO

BACKGROUND: The rare incidence of esophageal neuroendocrine carcinoma (NEC) and limited treatment experience result in insufficient clinical observations and unsuitable guidelines for its management. AIM: To investigate the prognostic value of pretreatment contrast-enhanced computed tomography (CT) characteristics in patients with esophageal NEC. METHODS: Seventy-seven esophageal NEC patients who received contrast-enhanced CT at two hospitals were enrolled in this study from June 2014 to December 2019. The clinical features and image characteristics were recorded accordingly. Univariate survival analysis was performed using the Kaplan-Meier method and log-rank test, and multivariate analysis was carried out with a Cox proportional hazards model. RESULTS: The multivariate analysis performed using the Cox proportional hazards model showed that N stage, adjuvant chemotherapy, and degree of enhancement were independent prognostic factors for overall survival (OS). Meanwhile, adjuvant chemotherapy was an independent prognostic factor for progression-free survival (PFS). The hazard ratios (HRs) of N stage, adjuvant chemotherapy, and degree of enhancement (mild vs moderate/marked) for OS were 0.426 (P = 0.024), 3.862 (P = 0.006), and 2.169/0.809 (P = 0.037), respectively. The HR of adjuvant chemotherapy for PFS was 6.432 (P < 0.001). Adjuvant chemotherapy was significantly associated with degree of enhancement (P = 0.018). CONCLUSION: Adjuvant chemotherapy is an independent prognostic factor for OS and PFS. Additionally, N stage and degree of enhancement are prognostic factors for OS in patients with esophageal NEC.

15.
Zhongguo Zhen Jiu ; 40(8): 799-802, 2020 Aug 12.
Artigo em Chinês | MEDLINE | ID: mdl-32869585

RESUMO

The effect of acupuncture-moxibustion on respiratory system and systemic immune inflammatory response were reviewed to explore the possible role of neuroimmunomodulation in the control of inflammatory response and the effect mechanism of cholinergic anti-inflammatory pathway on coronavirus disease 2019 (COVID-19). Acupuncture-moxibustion could produce the local and systemic anti-inflammatory effect on COVID-19 through the activation of cholinergic anti-inflammatory pathway. Compared with humoral anti-inflammatory pathway, the neuronal anti-inflammatory pathway has earlier initiation, rapider action, and more localization, which play a more important role in the initial stage of inflammatory response. This may be an important basis for acupuncture-moxibustion intervention in the early stage of COVID-19. In addition to cholinergic anti-inflammatory pathway, acupuncture-moxibustion may also play an anti-inflammatory role in activating sympathetic nerve, hypothalamic-pituitary-adrenal axis and other neural anti-inflammatory pathways. How acupuncture-moxibustion play its role in stimulating the vagus nerve and sympathetic nerve in different periods of inflammatory response, and whether the effect is based on the selection of acupoints and the methods of stimulation, will be the research direction of the transformation from basic research to clinical research for acupuncture-moxibustion.


Assuntos
Terapia por Acupuntura , Infecções por Coronavirus/prevenção & controle , Infecções por Coronavirus/terapia , Moxibustão , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Pneumonia Viral/terapia , Pontos de Acupuntura , Betacoronavirus , Humanos , Sistema Hipotálamo-Hipofisário , Sistema Hipófise-Suprarrenal
16.
J Orthop Surg Res ; 15(1): 373, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32873332

RESUMO

BACKGROUND: Knee osteoarthritis (KOA), with a high incidence in old-age population, adversely affects their life quality. The valgus knee bracing is an important physical therapy for KOA, but its clinical effects on pain release and functional improvement remained unclear. This meta-analysis is to systematically evaluate the clinical outcomes of valgus knee bracing in patients with KOA. METHODS: A meta-analysis of clinical randomized controlled trials (RCTs) on pain and functional changes in patients with KOA after using valgus knee braces. The search period was ranged from the inception of the database to May 2020. The enrolled research databases included PubMed, Embase, and Web of Science databases. Two investigators independently formulated inclusion criteria and exclusion criteria and screened and determined the final enrolled literature. Then the outcome indicators were extracted and organized from the included literature, and the risk of bias was assessed by Cochrane Handbook 5.0.1. RESULTS: A total of 10 articles were included in this study, including 739 patients. Eight articles were related to the visual analog scale (VAS) pain score, and the results showed that RR = - 0.29, 95% CI - 0.73, 0.15], P = 0.20; four articles were related to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function score, and the results showed that RR = - 0.15, 95% CI [- 0.41, 0.11], P = 0.26; two articles were related to the Knee Injury and Osteoarthritis Outcome Score (KOOS), and the results showed that RR = 0.58, 95% CI [- 4.25, 5.42], P = 0.81; and three articles were related to the KOOS Activities of Daily Living (KOOS-ADL), and the results showed that RR = 0.04, 95% CI [- 0.62, 0.69], P = 0.91. These results indicated that the valgus knee bracing has no statistical significance in pain and functional activity improvement of patients with KOA. The subgroup analysis showed that the follow-up time was the source of the heterogeneity of the VAS pain score. CONCLUSION: Our current evidence suggests that valgus knee bracing may not improve pain release and function activates in KOA patients in the long-term period, but only being beneficial to the short-term rehabilitation.

17.
Funct Plant Biol ; 2020 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-32951630

RESUMO

Although light is essential to photosynthesis, few studies have examined the effects of different LED spectra on photosynthate distribution in potato plants. Therefore, we exposed tuberising potato plants to white (W), red (R), blue (B) and green (G) LED treatments and compared tuber development and carbohydrate partitioning among the plants. R-treated plants had greater photosynthetic leaf area during tuber development compared with those under other treatments, thus enhancing assimilation. Although R-treated plants had higher 13C assimilation in the leaves, stems and roots than those under B treatment, there was no difference in partitioning of 13C assimilation and yield in the tubers of each plant between R and B treatments. For the tuber size, R-treated plants had a higher ratio of large tubers (>20 g) and a lower ratio of small (2-20 g) and medium-sized (10-20 g) tubers than those under W. B-treated plants had more medium-sized and large tubers than those under W. The reason may be that plants under R treatment distributed more assimilated 13C in their first tuber than those under other treatments. By contrast, plants under B balanced photosynthate distribution among their tubers. Leaves under G treatment had lower photosynthetic efficiency and ΦPSII than those under W, R or B treatment, which resulted in lower 13C photosynthate allocation in organs and lower tuber yield per plant than in R and B treatments. Overall, R treatment promoted 13C assimilation and led to more large tubers than other treatments. B-treated plants distributed more photosynthates into tubers rather than other organs and showed balanced tuber development.

18.
Artigo em Inglês | MEDLINE | ID: mdl-32941154

RESUMO

We aim at the optimization of the tracking control of a robot to improve the robustness, under the effect of unknown nonlinear perturbations. First, an auxiliary system is introduced, and optimal control of the auxiliary system can be seen as an approximate optimal control of the robot. Then, neural networks (NNs) are employed to approximate the solution of the Hamilton-Jacobi-Isaacs equation under the frame of adaptive dynamic programming. Next, based on the standard gradient attenuation algorithm and adaptive critic design, NNs are trained depending on the designed updating law with relaxing the requirement of initial stabilizing control. In light of the Lyapunov stability theory, all the error signals can be proved to be uniformly ultimately bounded. A series of simulation studies are carried out to show the effectiveness of the proposed control.

19.
Artigo em Inglês | MEDLINE | ID: mdl-32969848

RESUMO

BACKGROUND: The efficacy, safety, and outcome of rabbit antihuman thymocyte globulin (rATG) as initial therapy for children aplastic anemia (AA) were evaluated. PATIENTS AND METHODS: Sixty-one children with AA were retrospectively analyzed, including 43 patients with severe AA and 18 patients with transfusion-dependent nonsevere AA. All patients received rATG in combination with cyclosporine A between September 2005 and January 2015. RESULTS: The overall response rates were 55.7%, 68.9%, and 68.9% at 6, 12, and 18 months, respectively. Surprisingly, the overall complete response rate kept increasing from 9.8% at 12 months to 39.3% at 18 months, indicating a delayed response for rATG. Overall survival at 5 and 10 years was 72.1% and 67.2%, respectively. The overall survival of patients who responded between 3 and 12 months was significantly higher than that of nonresponders (71.4% vs. 47.4%).Antithymocyte globulin-related adverse reactions were significantly higher in severe AA (83.7%) than in nonsevere AA (55.6%) and these reactions were controllable and not life threatening with comprehensive measures. CONCLUSIONS: This retrospective study shows an encouraging response and survival results in children with AA treated with rATG. Prolonged assessments were needed to evaluate the delayed responses to rATG. rATG could be used as an alternative in the first-line treatment of childhood AA.

20.
Acta Pharm Sin B ; 10(8): 1521-1533, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32963947

RESUMO

Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein, targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. The codelivery system consists of a carrier-free strategy (drug-delivering-drug, DDD), fabricated by loading anti-miR155 on baicalein nanocrystals, named as baicalein nanorods (BNRs), followed by sialic acid coating to target macrophages. The codelivery system, with a diameter of 150 nm, enables efficient intracellular delivery of anti-miR155 and polarizes M1 to M2, while markedly lowers the level of inflammatory factors in vitro and in vivo. In particular, intracellular fate assay reveals that the codelivery system allows for sustained drug release over time after internalization. Moreover, due to prolonged blood circulation and improved accumulation at the AS plaque, the codelivery system significantly alleviates AS in animal model by increasing the artery lumen diameter, reducing blood pressure, promoting M2 polarization, inhibiting secretion of inflammatory factors and decreasing blood lipids. Taken together, the codelivery could potentially be used to treat vascular inflammation.

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