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Hua Xi Kou Qiang Yi Xue Za Zhi ; 32(6): 556-60, 2014 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-25665419


OBJECTIVE: The biological safety of a new developed silicone rubber for inflatable silastic prosthesis (SRISP) was evaluated. METHODS: Following the GB/T 16886.10-2005 standard, YY/T 0127.13-2009 standard, and GB/T 16886.11- 2011 standard, samples were prepared and tested by animal experiments, such as guinea pig maximization test, oral mucous membrane irritation test, and short-term systemic toxicity test (oral route). RESULTS: No obvious erythema and edema in the guinea pig abdominal skin were observed after 24, 48, and 72 h of stimulating touch, thus indicating that SRISP does not cause potential skin sensitivity. No local response to SRISP was found, and the visual observation and pathological findings of oral mucosa were normal and similar to that of the control group. Therefore, SRISP had no irritation response to oral mucosa. No clinical signs of toxicity were observed in rats, and no significant differences in weight and weight relative growth rate between extract group and blank control group (P > 0.05) were found. Thus, SRISP had no short-term systemic toxicity. CONCLUSION: These results indicated that SRISP met the requirement of biomedical materials and had good bio- security.

Cosméticos , Elastômeros de Silicone , Animais , Materiais Biocompatíveis , Dimetilpolisiloxanos , Cobaias , Próteses e Implantes , Ratos , Testes de Toxicidade
Psychiatry Res ; 201(2): 107-12, 2012 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-22398297


Abnormalities in amygdala activity have been implicated in adolescents and older adults with major depressive disorder (MDD), but few studies have focused on young adults with early-onset MDD. In this study, we measured amygdala activity in 27 young adults with early-onset MDD and 25 healthy controls (HC) using functional magnetic resonance imaging (fMRI) with an emotional processing task. Both groups showed significant bilateral activation within the amygdala to threat-related facial expressions. In the matching face task, the activations of the left amygdala, thalamus, prefrontal and temporal cortex were significantly greater while the activation of the right prefrontal was significantly lower for the MDD group compared with the HC group. For the MDD group, there was a significant positive correlation between the activity of the amygdala and scores on the Chinese version of the Center for Epidemiologic Studies Depression Scale. Overall, our findings suggest that young adults with early-onset MDD may be characterized by abnormalities in nodes along the fronto-limbic pathways when facing threat-related facial expression.

Tonsila do Cerebelo/fisiopatologia , Transtorno Depressivo Maior/fisiopatologia , Emoções/fisiologia , Expressão Facial , Interpretação de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Oxigênio/sangue , Adolescente , Nível de Alerta/fisiologia , Mapeamento Encefálico , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/psicologia , Discriminação Psicológica/fisiologia , Dominância Cerebral/fisiologia , Feminino , Humanos , Masculino , Vias Neurais/fisiologia , Córtex Pré-Frontal/fisiopatologia , Valores de Referência , Lobo Temporal/fisiopatologia , Tálamo/fisiopatologia , Adulto Jovem
Opt Express ; 13(10): 3673-80, 2005 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-19495274


We present the theoretical analysis and the numerical modeling of optical levitation and trapping of the stuck particles with a pulsed optical tweezers. In our model, a pulsed laser was used to generate a large gradient force within a short duration that overcame the adhesive interaction between the stuck particles and the surface; and then a low power continuous-wave(cw) laser was used to capture the levitated particle. We describe the gradient force generated by the pulsed optical tweezers and model the binding interaction between the stuck beads and glass surface by the dominative van der Waals force with a randomly distributed binding strength. We numerically calculate the single pulse levitation efficiency for polystyrene beads as the function of the pulse energy, the axial displacement from the surface to the pulsed laser focus and the pulse duration. The result of our numerical modeling is qualitatively consistent with the experimental result.