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1.
J Phys Condens Matter ; 32(17): 175503, 2020 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-31935706

RESUMO

Spin splitting of the nonmagnetic two dimensional (2D) layered NIIIXVI (N = Ga, In; X = S, Se, Te) monolayer is investigated based on the density functional theory. Due to the mirror symmetry, there is no Rashba spin splitting (RSS) in the freestanding NX plane. It is found that applying the external electric field perpendicular to the NX plane can result in sizable RSS around the Γ point due to the mirror symmetry breaking. The induced RSS is mainly influenced by the anions X and gradually strengthens with the increase of external electric field. The considerable RSS is observed in NTe systems. Moreover, the influence of in-plane biaxial strain on RSS is explored, and the tensile strain can enhance the RSS, especially for those bands around the Fermi level. Our theoretical investigation provides a deep insight in spin splitting behaviors in NX monolayers and agrees well with the experimental report.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31831441

RESUMO

Cross-media search from large-scale social network big data has become increasingly valuable in our daily life because it can support querying different data modalities. Deep hash networks have shown high potential in achieving efficient and effective cross-media search performance. However, due to the fact that social network data often exhibit text sparsity, diversity, and noise characteristics, the search performance of existing methods often degrades when dealing with this data. In order to address this problem, this article proposes a novel end-to-end cross-media semantic correlation learning model based on a deep hash network and semantic expansion for social network cross-media search (DHNS). The approach combines deep network feature learning and hash-code quantization learning for multimodal data into a unified optimization architecture, which successfully preserves both intramedia similarity and intermedia correlation, by minimizing both cross-media correlation loss and binary hash quantization loss. In addition, our approach realizes semantic relationship expansion by constructing the image-word relation graph and mining the potential semantic relationship between images and words, and obtaining the semantic embedding based on both internal graph deep walk and an external knowledge base. Experimental results demonstrate that DHNS yields better cross-media search performance on standard benchmarks.

4.
Angew Chem Int Ed Engl ; 58(44): 15655-15659, 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31393656

RESUMO

The single-step syngas-to-dimethyl ether (STD) process entails economic and technical advantages over the current industrial two-step process. Pd/ZnO-based catalysts have recently emerged as interesting alternatives to currently used Cu/ZnO/Al2 O3 catalysts, but the nature of the active site(s), the reaction mechanism, and the role of Pd and ZnO in the solid catalyst are not well established. Now, Zn-stabilized Pd colloids with a size of 2 nm served as the key building blocks for the methanol active component in bifunctional Pd/ZnO-γ-Al2 O3 catalysts. The catalysts were characterized by combining high-pressure operando X-ray absorption spectroscopy and DFT calculations. The enhanced stability, longevity, and high dimethyl ether selectivity observed makes Pd/ZnO-γ-Al2 O3 an effective alternative system for the STD process compared to Cu/ZnO/γ-Al2 O3 .

5.
J Spine Surg ; 5(1): 124-131, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31032447

RESUMO

Background: Decompressive surgery has a failure rate of between 25% and 32% based on patient reported improvement in clinical symptoms. Significant back pain is associated with 53% of failures of decompressive surgery, while also being associated with abnormal axial rotation motion. We report on the clinical performance of subjects receiving a novel axial rotation stabilization implant (ARO Spinal System, ARO Medical), while undergoing a surgical decompression for a herniated lumbar disc, a condition associated with low back pain and abnormal movement. Methods: This Danish Medicines Agency and Ethics Committee approved clinical trial prospectively investigated the use of the ARO® Spinal System as part of lumbar discectomy surgery in 20 patients. All subjects had a single level posterolateral lumbar herniation with symptoms lasting more than 6 weeks. They underwent an open discectomy at the symptomatic level, and received the implant. Results: No complications with the implant were observed. Four serious adverse events not related to the devices were reported, one subject had reoperation at 3 months. Leg pain median VAS score decreased from 70 to 2 at 1 year (P=0.01) back pain median VAS score from 48 to 6 (P=0.04). Satisfaction with surgery was 88%. Oswestry Disability Index scored likewise improvement going from 38 pre-operative to 5 at 1 year. Follow-up rate was excellent 100%. Conclusions: Discectomy with the ARO Spinal System proves equally safe as a standard discectomy at 1 year follow-up. The subjects had significant improvements in both leg and back pain. In addition, they did better than historical controls, though not statistically so in this patient sample.

6.
Front Genet ; 10: 109, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30838032

RESUMO

P311 is a highly conserved multifunctional protein. However, it does not belong to any established family of proteins, and its biological function has not been entirely determined. This study aims to reveal the unknown molecular and cellular function of P311. OCG (Overlapping Cluster Generator) is a clustering method used to partition a protein-protein network into overlapping clusters. Multifunctional proteins are at the intersection of relevant clusters. DAVID is an analytic tool used to extract biological meaning from a large protein list. Here we presented OD2 (OCG + DAVID + 2 human PPI datasets), a novel strategy to increase the likelihood to identify biological functions most pertinent to the multifunctional proteins. The principle of OD2 is that OCG prepares the protein lists from multifunctional protein relevant overlapping clusters, for a functional enrichment analysis by DAVID, and the similar functional enrichments, which occurs simultaneously when analyzing two human PPI datasets, are supposed to be the predicted functions. By applying OD2 to two reconstructed human PPI datasets, we supposed the function of the P311 in inflammatory responses, cell proliferation and coagulation, which were confirmed by the following biological experiments. Collectively, our study preliminarily found that P311 could play a role in inflammatory responses, cell proliferation and coagulation. Further studies are required to validate and elucidate the underlying mechanism.

7.
J Am Chem Soc ; 140(45): 15153-15156, 2018 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-30207157

RESUMO

Highly crystalline films of a silver-based coordination polymer, [Ag5(C6S6)] n (Ag-BHT, BHT = benzenehexathiol), have been prepared. The structure of Ag-BHT, solved by combining rotation electron diffraction and powder X-ray diffraction techniques, indicates that it has a lamellar structure with alternatively stacked two-dimensional Ag-S networks and layers composed of one-dimensional metal-dithiolene polymers. In addition, the polycrystalline Ag-BHT film shows high electrical conductivity of up to 250 S·cm-1 at 300 K. The ultraviolet-photoelectron spectroscopy and electronic band structure calculations reveal that this can be attributed to the partially filled valence band and the unique two-dimensional Ag-S networks.

8.
Sci Rep ; 8(1): 13884, 2018 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-30224678

RESUMO

The classical wavelet packet transform has been widely applied in the information processing field. It implies that the quantum wavelet packet transform (QWPT) can play an important role in quantum information processing. In this paper, we design quantum circuits of a generalized tensor product (GTP) and a perfect shuffle permutation (PSP). Next, we propose multi-level and multi-dimensional (1D, 2D and 3D) QWPTs, including a Haar QWPT (HQWPT), a D4 QWPT (DQWPT) based on the periodization extension and their inverse transforms for the first time, and prove the correctness based on the GTP and PSP. Furthermore, we analyze the quantum costs and the time complexities of our proposed QWPTs and obtain precise results. The time complexities of HQWPTs is at most 6 on 2n elements, which illustrates high-efficiency of the proposed QWPTs. Simulation experiments demonstrate that the proposed QWPTs are correct and effective.

10.
Artigo em Inglês | MEDLINE | ID: mdl-30071695

RESUMO

The food supply chain is a complex system that involves a multitude of "stakeholders" such as farmers, production factories, distributors, retailers and consumers. "Information asymmetry" between stakeholders is one of the major factors that lead to food fraud. Some current researches have shown that applying blockchain can help ensure food safety. However, they tend to study the traceability of food but not its supervision. This paper provides a blockchain-based credit evaluation system to strengthen the effectiveness of supervision and management in the food supply chain. The system gathers credit evaluation text from traders by smart contracts on the blockchain. Then the gathered text is analyzed directly by a deep learning network named Long Short Term Memory (LSTM). Finally traders' credit results are used as a reference for the supervision and management of regulators. By applying blockchain, traders can be held accountable for their actions in the process of transaction and credit evaluation. Regulators can gather more reliable, authentic and sufficient information about traders. The results of experiments show that adopting LSTM results in better performance than traditional machine learning methods such as Support Vector Machine (SVM) and Navie Bayes (NB) to analyze the credit evaluation text. The system provides a friendly interface for the convenience of users.


Assuntos
Comércio/economia , Comércio/organização & administração , Inocuidade dos Alimentos , Abastecimento de Alimentos , Participação dos Interessados , Algoritmos , Teorema de Bayes , Humanos , Pesquisa , Máquina de Vetores de Suporte
11.
Spine J ; 18(1): 122-129, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-28687252

RESUMO

BACKGROUND CONTEXT: Magnetic controlled growth rods (MCGRs) are increasingly popular for surgical treatment of severe early-onset scoliosis (EOS), because they allow noninvasive extensions with good growth maintenance. We combined an MCGR with a contralateral passive sliding rod construct with apical control on the convex side to improve efficiency in terms of costs and three-dimensional (3D) correction. PURPOSE: To investigate the feasibility, 3D correction, spinal growth, and complications of the apical control MCGR sliding rod hybrid. STUDY DESIGN: Two-center retrospective cohort study. PATIENT SAMPLE: A consecutive series of 17 children with EOS from two European spine centers were treated with the hybrid principle: 13 primary cases and 4 conversion cases from other growth instrumentation. Median age at surgery was 9 years (range: 6-18). Median follow-up time was 24 months (range: 12-31). OUTCOMES: Cobb angles (frontal Cobb, kyphosis, lordosis), rotation, spinal length gain, growth rate, and complications. METHODS: Radiographs and patient files were reviewed. All the patients received fully financed treatment within the national public health-care systems. RESULTS: Mean preoperative frontal Cobb angle was 59°, reduced postoperatively to 30° and was maintained throughout follow-up. Mean rotation of the apical vertebra improved from 27° to 18°, but was partially lost over time. Kyphosis decreased and lordosis was largely unaltered. Instrumented spine growth was maintained at a mean of 12 mm per year. One child had surgical revision because of progressive trunk shift, unrelated to the technique. The same child fell and sustained T1 and T2 fractures that were treated conservatively. Another child is planned for revision because of MCGR distraction failure. CONCLUSION: These early results show satisfactory frontal Cobb curve reduction and maintenance of spinal growth after using a new hybrid concept of a single magnetic growth rod and contralateral apical control sliding rods. A single magnetic growth rod in this combination may work equally well as traditional or dual magnetic growth rods. This new concept may represent a significant gain in both cost-effectiveness of growth rod treatment and 3D correction in EOS.


Assuntos
Fixadores Internos/efeitos adversos , Magnetismo , Procedimentos Ortopédicos/métodos , Escoliose/cirurgia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Procedimentos Ortopédicos/efeitos adversos , Procedimentos Ortopédicos/instrumentação , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Reoperação/estatística & dados numéricos , Vértebras Torácicas/cirurgia
12.
Cell Physiol Biochem ; 42(5): 1755-1768, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28746918

RESUMO

Backgroud/Aims: The effects of rapamycin (RPM) on wound healing have been previously studied. However, reciprocal contradictory data have been reported, and the underlying mechanism remains unclear. This study aims to uncover differential role of RPM in regulation of wound healing and explore the possible mechanism. METHODS: C57BL/6J mice and epidermal cells were treated with different doses of RPM. The wound re-epithelialization was observed by hematoxylin and eosin (HE) staining. The expression of IL-15 and IGF-1 were detected by immunohistochemistry and quantitative real-time PCR. Epidermal cell survival was determined by CCK-8 assays. Moreover, the mTORC1 and mTORC2 pathway were examined by western blot analysis. RESULTS: This study showed that differential doses of RPM could lead to separate consequences in epidermis. Histological analyses showed that low-dose RPM promoted wound healing, and enhanced the expression of IL-15 and IGF-1. Furthermore, western blot analysis showed that the effect of low-dose RPM in epidermis were not through mTORC1 pathway. Instead, activation of the Akt/mTORC2 pathway was involved in low-dose RPM-induced IL-15 and IGF-1 production in epidermis, while high-dose RPM inhibited the expression of IL-15 and IGF-1 and the activity of mTORC1 and mTORC2 pathway. CONCLUSION: This study for the first time demonstrated that RPM-mediated wound healing was dose-dependent.


Assuntos
Fator de Crescimento Insulin-Like I/metabolismo , Interleucina-15/metabolismo , Alvo Mecanístico do Complexo 2 de Rapamicina/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Transdução de Sinais/efeitos dos fármacos , Sirolimo/farmacologia , Animais , Sobrevivência Celular/efeitos dos fármacos , Células Cultivadas , Modelos Animais de Doenças , Células Epidérmicas , Epiderme/efeitos dos fármacos , Epiderme/metabolismo , Epiderme/patologia , Imuno-Histoquímica , Fator de Crescimento Insulin-Like I/genética , Interleucina-15/genética , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Fosforilação/efeitos dos fármacos , Reação em Cadeia da Polimerase em Tempo Real , Cicatrização/efeitos dos fármacos
13.
Phys Chem Chem Phys ; 19(31): 20735-20748, 2017 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-28740994

RESUMO

The adsorption of Aun (n = 1-4) clusters on perfect and defective MoS2 monolayers is studied using density functional theory. For the pristine MoS2 monolayer, our results show that the electrons are transferred from the support to the adsorbed Au clusters, thus a p-doping effect is achieved in the pristine MoS2 monolayer by the Au cluster adsorption, which is in good agreement with the experimental findings. The adsorption of Au clusters can introduce mid-gap states, which modify the electronic and magnetic properties of the systems. The adsorbates containing an odd number of Au atoms can introduce a spin magnetic moment of 1 µB into the perfect MoS2 monolayer, while those systems containing an even number of Au atoms are spin-unpolarized. Two categories of defects, i.e., a single S vacancy and Mo antisite defect with one Mo atom replacing one S atom, are considered for the defective monolayer MoS2. Compared with the pristine MoS2 monolayer, the adsorption energies for Au clusters are significantly increased for the MoS2 monolayer with a single S vacancy, and there are more electrons transferred from the MoS2 monolayer with an S vacancy to the Au clusters. The mid-gap states and odd-even oscillation magnetic behavior can also be observed when Au clusters are adsorbed on the MoS2 monolayer with an S vacancy. For those systems of Au clusters on MoS2 monolayers with Mo antisite defects, the adsorption energies as well as the magnitude and the direction of transferred charge are similar to those for the MoS2 monolayer with an S vacancy. The spin-polarizations appear in all systems with Mo antisite defects. Our investigations suggest that the electronic and magnetic properties of MoS2 nanosheets can be effectively modulated by the adsorption of Au clusters.

14.
Burns Trauma ; 5: 16, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28573147

RESUMO

Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. The epidemiology and outcomes of admitted burn patients since 1958 were reviewed. Furthermore, main achievements of basic and clinical research for the past roughly 60 years were presented. These achievements mainly included the Chinese Rule of Nine, fluid resuscitation protocol, experience in inhalation injury, wound treatment strategies, prevention and treatment of burn infections, nutrition therapy, organ support therapies, and rehabilitation. The progress shaped and enriched modern Chinese burn medicine and promoted the development of world burn medicine.

15.
J Surg Res ; 214: 182-189, 2017 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-28624042

RESUMO

BACKGROUND: Electrical burns are important causes of trauma worldwide. This study aims to analyze the clinical characteristics, wound management, and outcome of electric burns. METHODS: This retrospective study was performed at the Institute of Burn Research of the Third Military Medical University during 2013-2015. Data including the demographics, injury patterns, wound treatment, and outcomes were collected and analyzed. RESULTS: A total of 595 electrical burn patients (93.8% males) were included. The average age was 37.3 ± 14.6 y, and most patients (73.5%) were aged 19∼50 years. Most patients (67.2%) were injured in work-related circumstances. The mean total body surface area was 8.8 ± 11.8% and most wounds (63.5%) were full-thickness burns. Operation times of high-voltage burns and current burns were higher than those of low-voltage burns and arc burns, respectively. Of the 375 operated patients, 83.2% (n = 312) underwent skin autografting and 49.3% (n = 185) required skin flap coverage. Common types of skin flaps were adjacent (50.3%), random (42.2%), and pedicle (35.7%). Amputation was performed in 107 cases (18.0%) and concentrated on the hands (43.9%) and upper limbs (39.3%). The mean length of stay was 42.9 ± 46.3 d and only one death occurred (0.2%). Current burns and higher numbers of operations were major risk factors for amputation and length of stay, respectively. CONCLUSIONS: Electrical burns mainly affected adult males with occupational exposures in China. Skin autografts and various skin flaps were commonly used for electric burn wound management. More standardized and effective strategies of treatment and prevention are still needed to decrease amputation rates.


Assuntos
Queimaduras por Corrente Elétrica/terapia , Adulto , Unidades de Queimados , Queimaduras por Corrente Elétrica/diagnóstico , Queimaduras por Corrente Elétrica/epidemiologia , Queimaduras por Corrente Elétrica/etiologia , China/epidemiologia , Terapia Combinada , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Traumatismos Ocupacionais/diagnóstico , Traumatismos Ocupacionais/epidemiologia , Traumatismos Ocupacionais/etiologia , Traumatismos Ocupacionais/terapia , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
16.
Nanoscale Res Lett ; 12(1): 357, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28525951

RESUMO

Zigzag graphene nanoribbons (ZGNRs) are expected to serve as the promising component in the all-carbon spintronic device. It remains challenging to fabricate a device based on ZGNRs with high spin-filter efficiency and low experimental complexity. Using density functional theory combined with nonequilibrium Green's function technique, we studied the spin-dependent transport properties of the tailored zigzag graphene nanoribbon. A perfect spin-filtering effect is found in the tailored structure of ZGNR. The nearly 100% spin-polarized current and high magneto-resistance ratio can be obtained by applying a homogeneous magnetic field across the device. The distribution of spin up and spin down states at the bridge carbon atom plays a dominant role in the perfect spin filtering. The tailoring of ZGNR provides a new effective approach to graphene-based spintronics.

17.
Sci Rep ; 7: 46066, 2017 04 06.
Artigo em Inglês | MEDLINE | ID: mdl-28383066

RESUMO

Burns are a major cause of injury worldwide. We investigated the epidemiology and outcomes of burn patients in a major burn center in southwest China between 2011 and 2015 to provide guidance for burn prevention. Of the 6,325 included burn patients, 66.8% were male and 34.7% were 0 ~ 6 years old. The incidence of burns peaked in autumn. Scald was the most common cause of burns, which was predominant in patients aged 0 ~ 6 years. The mean total body surface area (TBSA) of burns was 13.4%, and patients with burns ≤10% TBSA comprised 64.1% of all cases. Patients with full-thickness burns accounted for 40.1% of all patients and 81.0% of operated patients; these burns were primarily caused by flame (34.8%), scald (21.0%), and electricity (20.4%). Fifty-six deaths occurred (mortality 0.9%), and risk factors included full-thickness burns, larger TBSA and older age. The median length of stay was 17 days, and major risk factors included more operations, better outcomes and larger TBSA. Our data showed that closer attention should be paid to children under 6 years old, males, incidents in autumn and scald burns to prevent burn injuries. Furthermore, individualized burn prevention and treatment measures based on related risk factors should be adopted.


Assuntos
Unidades de Queimados/estatística & dados numéricos , Queimaduras/epidemiologia , Adolescente , Idoso , Idoso de 80 Anos ou mais , Queimaduras/etiologia , Queimaduras/mortalidade , Criança , Pré-Escolar , China/epidemiologia , Feminino , Humanos , Lactente , Recém-Nascido , Tempo de Internação , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença , Fatores de Tempo
18.
Burns ; 43(6): 1306-1317, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28372828

RESUMO

BACKGROUND: Burns are a major form of injury in children worldwide. This study aimed to investigate the epidemiology, outcome, cost and risk factors of pediatric burns in southwest China. METHODS: This retrospective study was performed at the Institute of Burn Research of the Third Military Medical University from 2011 to 2015. Data, including demographic, injury-related, and clinical data and patient outcome, were collected from medical records. RESULTS: A total of 2478 children with burns (58.03% boys), accounting for 39.2% of total burn patients, were included. The average age of the burn patients was 2.86±2.86years, and most patients (85.55%) were under five years old. The incidence of burns peaked in January, February and May. Scald burns were the most frequent (79.06%), followed by flame burns (14.0%) and electrical burns (3.35%). Limbs were the most common burn sites (69.73%), and the average total body surface area (TBSA) was 11.57±11.61%. The percentage of children who underwent operations and the number of operations were significantly increased in cases of electrical burns, the older-age group, a larger TBSA and full-thickness burns. Six deaths were recorded, yielding a mortality of 0.24%. The median length of stay and cost were 14days and 9541 CNY, respectively, and the major risk factors for length of stay and cost were the TBSA, number of operations, full-thickness burns and outcome. CONCLUSIONS: In southwest China, among children under five years old, scald and flame burns should become the key prevention target, and future prevention strategies should be based on related risk factors.


Assuntos
Queimaduras/epidemiologia , Custos de Cuidados de Saúde , Tempo de Internação/estatística & dados numéricos , Adolescente , Distribuição por Idade , Superfície Corporal , Queimaduras/economia , Queimaduras/terapia , Queimaduras por Corrente Elétrica/economia , Queimaduras por Corrente Elétrica/epidemiologia , Queimaduras por Corrente Elétrica/terapia , Criança , Pré-Escolar , China/epidemiologia , Desbridamento , Feminino , Hidratação , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Ressuscitação , Estudos Retrospectivos , Fatores de Risco , Distribuição por Sexo , Transplante de Pele , Índices de Gravidade do Trauma
19.
Int J Rheum Dis ; 20(8): 941-948, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28294540

RESUMO

AIM: The aim of this study was to evaluate the therapeutic effect of a traditional Chinese medicine (TCM), Bushen-Jianpi-Huoxue decoction (BJHD), on diabetic osteoporosis (DOP) and the action mechanisms likely mediated by nuclear factor-kappa B (NF-κB) and Wnt signaling pathways. METHODS: Fifty-five male Wistar rats were used in this study; they were divided into normal control (n = 10) and established DOP model (n = 45) groups. The DOP model was induced using a combination high carbohydrate - high fat diet and intraperitoneal injections of streptozotocin (STZ). The successfully induced animals were randomized to the model, Western medicine, TCM and control groups. Levels of fasting blood glucose; insulin; serum Ca, P and alkaline phosphatase, and the femoral bone mineral density (BMD) were measured. Furthermore, messenger RNA (mRNA) levels of cytokines in the Wnt and NF-κB signaling pathways were measured using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Thirty rats were successfully established as the DOP model (10/group). After treatment, the levels of fasting blood glucose, insulin resistance and alkaline phosphatase in the TCM group rats were lower, while P and BMD were higher than those in the model groups. The mRNA levels of cytokines in the Wnt signaling pathway were higher in the TCM group than those in the model group. Moreover, the expressions of factors in the NF-κB pathway were markedly lower in the TCM group than they were in the model group. CONCLUSION: Bushen-Jianpi-Huoxue decoction relieved DOP by activating the Wnt signaling pathway while inhibiting NF-κB signaling.


Assuntos
Conservadores da Densidade Óssea/farmacologia , Densidade Óssea/efeitos dos fármacos , Diabetes Mellitus Experimental/tratamento farmacológico , Medicamentos de Ervas Chinesas/farmacologia , Fêmur/efeitos dos fármacos , Hipoglicemiantes/farmacologia , NF-kappa B/metabolismo , Osteoporose/prevenção & controle , Via de Sinalização Wnt/efeitos dos fármacos , Absorciometria de Fóton , Animais , Biomarcadores/sangue , Glicemia/efeitos dos fármacos , Glicemia/metabolismo , Subunidade alfa 1 de Fator de Ligação ao Core/genética , Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/etiologia , Dieta Hiperlipídica , Carboidratos da Dieta , Fêmur/diagnóstico por imagem , Fêmur/metabolismo , Regulação da Expressão Gênica , Insulina/sangue , Resistência à Insulina , Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética , Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo , Masculino , NF-kappa B/genética , Osteoporose/sangue , Osteoporose/diagnóstico por imagem , Osteoporose/etiologia , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Ratos Wistar , Estreptozocina , Fator 6 Associado a Receptor de TNF/genética , Fator 6 Associado a Receptor de TNF/metabolismo , Fatores de Transcrição/genética , Fatores de Transcrição/metabolismo , beta Catenina/genética , beta Catenina/metabolismo
20.
Clin Spine Surg ; 30(3): E310-E316, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28323717

RESUMO

STUDY DESIGN: Retrospective analysis of 16 patients. SUMMARY OF BACKGROUND DATA: The lumbar split fracture-dislocation is a rare but severe injury, which is type C1.2.1 fracture in the Association for the Study of Internal Fixation spine fracture classification. The axial compressive and torsional force shattered the vertebral body into 2 halves and displaced them rotationally. This kind of fracture is so highly unstable that the treatment is very challenging. PURPOSE: The purpose of this study was to report and compare on clinical outcome and complications of patients with lumbar split fracture-dislocation which had been treated either short-segment or long-segment posterior fixation and anterior fusion. MATERIALS AND METHODS: A total of 16 patients with acute, split fracture-dislocation of the lumbar spine from March 2000 to May 2009 in our department were recruited. Seven patients (group I) treated by long-segment posterior fixation (2 levels above and 2 below the fracture) and anterior corpectomy and strut grafting. With the improvement of surgical technique and instrument, 9 patients after August 2004 were treated by short-segment posterior fixation (1 level above and 1 below, and included the fractured vertebrae itself) and anterior discectomy and strut grafting. The intraoperative blood loss, operation time, complications of operation, time to achieve bony fusion, Frankel scale, Oswestry Disability index, and Visual Analogue Pain Scale the Cobb angle were collected and compared. RESULTS: The mean follow-up was 33.4 months for group I and 36.2 months for group II. The operation time was 457.1 minutes in group I which was significantly longer than 240.0 minutes in group II. The total blood loss was for group I was 2001.4 mL (range, 1580-2500 mL) and for group II was 730.6 mL (range, 430-950 mL). There was no neurological deterioration after surgery in both group and no difference in neurological outcome between the 2 groups. The loss of correction in Cobb angle averaged at the final evaluation was 2 and 5 degrees for groups I and II, respectively. There was no radiologically visible pseudarthrosis. The postoperative Visual Analogue Pain Scale score was 3.3 and 2.7 for groups I and II, respectively. In the SF-36 survey, after surgery the domains Role physical and Bodily pain improved significantly only in group B (P<0.05 and P=0.06, respectively). Time to achieve bony fusion in group I was 7.9 months which was significantly longer than 3.8 months in group II. Complications included 3 urinary infections, 1 decubitus ulcer, and 1 superficial infection that were cured by antibiotics. Screw breakage was found in 1 patient in the group II. CONCLUSIONS: The lumbar sagittal split fracture-dislocation is a rare but severe injury, which can be treated either with short-segment or long-segment posterior fixation and anterior fusion. The short construct with pedicle screws in the fractured vertebrae followed by the maneuver of rod derotation can obtain anatomic reduction, restoration of 3-column alignment, and decompress the affected neural elements by restoration of the normal canal dimension. It may be a better therapeutic option for the highly unstable lumbar fracture of C1.2.1.


Assuntos
Fratura-Luxação/cirurgia , Fixação Interna de Fraturas/métodos , Fraturas da Coluna Vertebral/cirurgia , Fusão Vertebral/métodos , Adolescente , Adulto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estatísticas não Paramétricas , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
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