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1.
Neural Regen Res ; 16(2): 205-213, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32859765

RESUMO

Perinatal complications, such as asphyxia, can cause brain injuries that are often associated with subsequent neurological deficits, such as cerebral palsy or mental retardation. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role not only due to their central function in metabolism but also because many proteins with apoptosis-related functions are located in the mitochondrion. Among these proteins, apoptosis-inducing factor has already been shown to be an important factor involved in neuronal cell death upon hypoxia-ischemia, but a better understanding of the mechanisms behind these processes is required for the development of more effective treatments during the early stages of perinatal brain injury. In this review, we focus on the molecular mechanisms of hypoxic-ischemic encephalopathy, specifically on the importance of apoptosis-inducing factor. The relevance of apoptosis-inducing factor is based not only because it participates in the caspase-independent apoptotic pathway but also because it plays a crucial role in mitochondrial energetic functionality, especially with regard to the maintenance of electron transport during oxidative phosphorylation and in oxidative stress, acting as a free radical scavenger. We also discuss all the different apoptosis-inducing factor isoforms discovered, focusing especially on apoptosis-inducing factor 2, which is only expressed in the brain and the functions of which are starting now to be clarified. Finally, we summarized the interaction of apoptosis-inducing factor with several proteins that are crucial for both apoptosis-inducing factor functions (pro-survival and pro-apoptotic) and that are highly important in order to develop promising therapeutic targets for improving outcomes after perinatal brain injury.

2.
J Neuroinflammation ; 17(1): 295, 2020 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-33036632

RESUMO

BACKGROUND: Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms controlling this special sterile inflammation after SCI are still not fully elucidated. It is known that damage-associated molecular patterns (DAMPs) released from necrotic cells after injury can trigger severe inflammation. High mobility group box 1(HMGB1), a ubiquitously expressed DNA binding protein, is an identified DAMP, and our previous study demonstrated that reactive astrocytes could undergo necroptosis and release HMGB1 after SCI in mice. The present study aimed to explore the effects and the possible mechanism of HMGB1on macrophages/microglia polarization, as well as the neuroprotective effects by HMGB1 inhibition after SCI. METHODS: In this study, the expression and the concentration of HMGB1 was determined by qRT-PCR, ELISA, and immunohistochemistry. Glycyrrhizin was applied to inhibit HMGB1, while FPS-ZM1 to suppress receptor for advanced glycation end products (RAGE). The polarization of macrophages/microglia in vitro and in vivo was detected by qRT-PCR, immunostaining, and western blot. The lesion area was detected by GFAP staining, while neuronal survival was examined by Nissl staining. Luxol fast blue (LFB) staining, DAB staining, and western blot were adopted to evaluate the myelin loss. Basso-Beattie-Bresnahan (BBB) scoring and rump-height Index (RHI) assay was applied to evaluate locomotor functional recovery. RESULTS: Our data showed that HMGB1 can be elevated and released from necroptotic astrocytes and HMGB1 could induce pro-inflammatory microglia through the RAGE-nuclear factor-kappa B (NF-κB) pathway. We further demonstrated that inhibiting HMGB1 or RAGE effectively decreased the numbers of detrimental pro-inflammatory macrophages/microglia while increased anti-inflammatory cells after SCI. Furthermore, our data showed that inhibiting HMGB1 or RAGE significantly decreased neuronal loss and demyelination, and improved functional recovery after SCI. CONCLUSIONS: The data implicated that HMGB1-RAGE axis contributed to the dominant pro-inflammatory macrophages/microglia-mediated pro-inflammatory response, and inhibiting this pathway afforded neuroprotection for SCI. Thus, therapies designed to modulate immune microenvironment based on this cascade might be a prospective treatment for SCI.

3.
Rapid Commun Mass Spectrom ; : e8959, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33001505

RESUMO

RATIONALE: Iris tectorum Maxim is a traditional medicinal herb that is commonly utilized for treating inflammatory conditions. The present study investigated the fragmentation patterns of isoflavone glycosides and their qualitative analysis. In addition, lipopolysaccharide (LPS)-induced RAW264.7 macrophages were used to evaluat the anti-inflammatory properties of I. tectorum Maxim samples collected at different time points during the year. METHOD: High-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (HPLC/Q-TOF-MS/MS) and HPLC-DAD were employed for the qualitative and quantitative analysis. The fragmentation patterns of these isoflavones were observed in negative electrospray ionization mode with collision-induced dissociation (CID). Their anti-inflammatory activity was assessed via nitric oxide (NO) production in LPS-treated RAW 264.7 macrophages. RESULTS: A total of 15 chemical components were observed and tentatively identified by HPLC/Q-TOF-MS. At low collision energy, the relative abundances of the aglycone radical anion Y0 - , [Y0 -H]-• , [Y0 -CH3 ]-• , and [Y0 -H-CH2 ]-• were used for the structural characterization of tectoridin and tectorigenin-4'-O-ß-D-glucoside. The radical ions [Y0 -CH3 ]-• and [Y0 -H-2CH3 ]-• were also employed to differentiate between iristectorin A and iristectorin B based upon their high energy CID spectra. Levels of 9.02 mg/g of tectoridin and 1.04 mg/g of tectorigenin were found in samples collected in June, which exhibited 69.7% NO inhibitory activity. CONCLUSION: The characteristic fragmentation patterns enabled us to reliably identify isoflavone glycosides. The results of the quantitative determination and NO inhibitory activity offer insight into the optimal I. tectorum Maxim harvesting time.

4.
Cancer Commun (Lond) ; 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33025763

RESUMO

BACKGROUND: Whether non-sentinel lymph node (SLN)-positive melanoma patients can benefit from completion lymph node dissection (CLND) is still unclear. The current study was performed to identify the prognostic role of non-SLN status in SLN-positive melanoma and to investigate the predictive factors of non-SLN metastasis in acral and cutaneous melanoma patients. METHODS: The records of 328 SLN-positive melanoma patients who underwent radical surgery at four cancer centers from September 2009 to August 2017 were reviewed. Clinicopathological data including age, gender, Clark level, Breslow index, ulceration, the number of positive SLNs, non-SLN status, and adjuvant therapy were included for survival analyses. Patients were followed up until death or June 30, 2019. Multivariable logistic regression modeling was performed to identify factors associated with non-SLN positivity. Log-rank analysis and Cox regression analysis were used to identify the prognostic factors for disease-free survival (DFS) and overall survival (OS). RESULTS: Among all enrolled patients, 220 (67.1%) had acral melanoma and 108 (32.9%) had cutaneous melanoma. The 5-year DFS and OS rate of the entire cohort was 31.5% and 54.1%, respectively. More than 1 positive SLNs were found in 123 (37.5%) patients. Positive non-SLNs were found in 99 (30.2%) patients. Patients with positive non-SLNs had significantly worse DFS and OS (log-rank P < 0.001). Non-SLN status (P = 0.003), number of positive SLNs (P = 0.016), and adjuvant therapy (P = 0.025) were independent prognostic factors for DFS, while non-SLN status (P = 0.002), the Breslow index (P = 0.027), Clark level (P = 0.006), ulceration (P = 0.004), number of positive SLNs (P = 0.001), and adjuvant therapy (P = 0.007) were independent prognostic factors for OS. The Breslow index (P = 0.020), Clark level (P = 0.012), and number of positive SLNs (P = 0.031) were independently related to positive non-SLNs and could be used to develop more personalized surgical strategy. CONCLUSIONS: Non-SLN-positive melanoma patients had worse DFS and OS even after immediate CLND than those with non-SLN-negative melanoma. The Breslow index, Clark level, and number of positive SLNs were independent predictive factors for non-SLN status.

5.
BJPsych Open ; 6(6): e126, 2020 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-33090091

RESUMO

BACKGROUND: Understanding the patterns of treatment response is critical for the treatment of patients with schizophrenia; one way to achieve this is through using a longitudinal dynamic process study design. AIMS: This study aims to explore the response trajectory of antipsychotics and compare the treatment responses of seven different antipsychotics over 6 weeks in patients with schizoprenia (trial registration: Chinese Clinical Trials Registry Identifier: ChiCTR-TRC-10000934). METHOD: Data were collected from a multicentre, randomised open-label clinical trial. Patients were evaluated with the Positive and Negative Syndrome Scale (PANSS) at baseline and follow-up at weeks 2, 4 and 6. Trajectory groups were classified by the method of k-means cluster modelling for longitudinal data. Trajectory analyses were also employed for the seven antipsychotic groups. RESULTS: The early treatment response trajectories were classified into a high-trajectory group of better responders and a low-trajectory group of worse responders. The results of trajectory analysis showed differences compared with the classification method characterised by a 50% reduction in PANSS scores at week 6. A total of 349 patients were inconsistently grouped by the two methods, with a significant difference in the composition ratio of treatment response groups using these two methods (χ2 = 43.37, P < 0.001). There was no differential contribution of high- and low trajectories to different drugs (χ2 = 12.52, P = 0.051); olanzapine and risperidone, which had a larger proportion in the >50% reduction at week 6, performed better than aripiprazole, quetiapine, ziprasidone and perphenazine. CONCLUSIONS: The trajectory analysis of treatment response to schizophrenia revealed two distinct trajectories. Comparing the treatment responses to different antipsychotics through longitudinal analysis may offer a new perspective for evaluating antipsychotics.

6.
Artigo em Inglês | MEDLINE | ID: mdl-33090626

RESUMO

A 58-year-old male was admitted to our hospital for a pancreatic cystic mass. Laboratory examination showed elevated levels of ALT (272 U/L, normal range, 9-50), AST (142 mg/L, normal range, 15-40), GGT (483 IU/ml, normal range, 10-60), AKP (542 U/L, normal range, 45-125), total bilirubin (21.9 U/L, normal range, 5-21), direct bilirubin (12.4 U/L, normal range, <6), CEA (7.21 ng/ml, normal range, 0-5), CA19-9 (58.91 U/ml, normal range, 0-39) and NSE (24.16 ng/ml, normal range, 0-20).

7.
Artif Cells Nanomed Biotechnol ; 48(1): 1272-1281, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33084450

RESUMO

Volume resuscitation is an important early treatment for haemorrhagic shock. Haemoglobin-based oxygen carrier (HBOC) can expand the volume and provide oxygen for tissues. Vascular leakage is common complication in the process of haemorrhagic shock and resuscitation. The aim of this study was to observe the effects of HBOC (a bovine-derived, cross-linked tetramer haemoglobin oxygen-carrying solution, 0.5 g/L) on vascular leakage in rats after haemorrhagic shock. A haemorrhagic shock rat model and hypoxic vascular endothelial cells (VECs) were used. The role of intercellular junctions and endothelial glycocalyx in the protective effects of HBOC and the relationship with mitochondrial function were analysed. After haemorrhagic shock, the pulmonary vascular permeability to FITC-BSA, Evans Blue was increased, endothelial glycocalyx was destroyed and the expression of intercellular junction proteins was decreased. After haemorrhagic shock, a small volume of HBOC solution (6 ml/kg) protected pulmonary vascular permeability, increased structural thickness of endothelial glycocalyx, the levels of its components and increased expression levels of the intercellular junction proteins ZO-1, VE-cadherin and occludin. Moreover, HBOC significantly increased oxygen delivery and consumption in rats, improved VEC mitochondrial function and structure. In conclusion, HBOC mitigates endothelial leakage by protecting endothelial glycocalyx and intercellular junctions through improving mitochondrial function and tissue oxygen delivery.

8.
Biochim Biophys Acta Gen Subj ; 1865(1): 129756, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33010351

RESUMO

BACKGROUND: Crotonase superfamily members exhibit great catalytic diversity towards various acyl-CoA substrates. A common CoA moiety binding pattern is usually observed in this family, understanding the substrate-binding mechanism would facilitate the rational engineering of crotonases for improved properties. METHODS: We applied X-ray crystallography to investigate a putative enoyl-CoA hydratase/isomerase OdaA in Pseudomonas aeruginosa. Thermal shift assay (TSA) were performed to explore the binding of OdaA with CoA thioester substrates. Furthermore, we performed molecular dynamics (MD) simulations to elucidate the dynamics of its CoA-binding site. RESULTS: We solved the crystal structures of the apo and CoA-bound OdaA. Thermal shift assay (TSA) showed that CoA thioester substrates bind to OdaA with a different degree. MD simulations demonstrated that the C-terminal alpha helix underwent a structural transition and a hinge region would associate with this conformational change. CONCLUSIONS: TSA in combination with MD simulations elucidate that the dynamics of C-terminal alpha helix in CoA-binding, and a hinge region play an important role in conformational change. GENERAL SIGNIFICANCE: Those results help to extend our knowledge about the nature of crotonases and would be informative for future mechanistic studies and industry applications.

9.
J Ethnopharmacol ; 266: 113444, 2020 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-33027641

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Acorn obtained from the Quercus liaotungensis Koidz tree is consumed as a Chinese folk medicine for the treatment of diarrhea, abdominal pain, and inflammation, also having strong antioxidant activity and have been utilized for the treatment of diabetes in China. However, its mechanism of action on complications of diabetes and oxidative stress is unclear. AIM OF THE STUDY: The purpose of this research was to assess the effects of acorn (Quercus liaotungensis Koidz) ethanol extract (AE) on pancreatic ß-cell dysfunction through a streptozotocin (STZ)-damaged mouse normal pancreatic ß-cell (MIN6 cell) model in vitro, and by using a high-fat and high-sugar diet with STZ-induced diabetic rat model in vivo to explore the possible mechanism of action against diabetes. MATERIALS AND METHODS: MIN6 cells were pretreated with AE (20, 40, 80 µM) for 2 h and then treated with 3 mM STZ for 24 h. Cell viability was measured by MTT assay. The amount of intracellular reactive oxygen species was measured by 2,7-dichlorodi-hydrofluorescein diacetate. The activities of insulin secretion, superoxide dismutase, catalase and glutathione were determined by kits. Sprague Dawley rats were either given normal feed or a high sugar and fat diet for four weeks, followed STZ (25 mg/kg, via i. p.) was given. Rats with fasting blood glucose ≥11.1 mmol/l after one week were deemed to be diabetic. Animals were divided into 5 groups, which received saline (10 mL/kg), metformin (200 mg/kg), or AE at doses of 200 and 400 mg/kg during 4 weeks by oral gavage. Blood samples were used to evaluate hematological and biochemical indicators, and pancreas was removed for post-analysis. Body weight and fasting blood glucose were recorded weekly. The expression levels of Bax, Bcl-2, p38, p-p38, Nrf2 and HO-1 were determined by Western blot. RESULTS: Data showed that AE inhibited apoptosis and increased antioxidant level in STZ-induced MIN6 cells. In addition, the AE-administered group lowered blood glucose, increased insulin secretion, and alleviated weight loss in the diabetic rats. Histopathologically, the AE-administered group reduced pancreatic injury by significantly restoring the insulin content in ß-islets. It was observed that the anti-diabetic effects of AE were associated with the suppressed the p38 MAPK pathway and actived the Nrf2 pathway. CONCLUSIONS: The ameliorative impact of AE on diabetes may be attributed to protection of the function of pancreatic ß islets and by improving serum insulin levels, hence reducing the blood glucose, which involved in the p38 MAPK and Nrf2 pathways.

10.
J Affect Disord ; 279: 183-190, 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33059221

RESUMO

BACKGROUND: Dimensions are recommended as replacements for diagnostic categories of depression, but clinicians continue to use categories. Categories are appropriate if major, underlying changes in symptom structure occur above a clinical cut-off on a depression continuum. METHODS: Cross-sectional surveys of Chinese undergraduates (n = 39,446) 2014-2018 measured self-reported depressive symptoms, associated psychopathology and etiological risk factors using standardised instruments. We created a continuum using PHQ-9 scores and tested linear and extra-linear contrasts in associated psychopathology, and etiology. We carried out latent class analyses (LCA). RESULTS: Most symptoms showed linear increase, but depressed mood, anhedonia, and suicidal ideation showed marked increase at the severe end of the continuum. There was extra-linear increase in associated psychotic symptoms, other psychopathology, age, low family income, chronic pain and physical illness, childhood physical and sexual abuse, and neglect. Four LCs corresponding to Melancholic, Severe melancholic, Non-melancholic, and Mild depression were confirmed, but only above a clinical cut-off along the continuum. Etiological risk factors did not differentiate between classes but showed overall dramatic increase in impact above threshold of clinical severity. LIMITATIONS: Only one self-report instrument was used (PHQ-9) to measure depression and diagnoses were not validated by clinical interviews. CONCLUSIONS: Categories are necessary to describe the dramatic changes in underlying structure and symptom associations above a clinical threshold of severity. These result from extra-linear impact of etiological risk factors at the severe end of the depression continuum. Although the study confirmed melancholic and non-melancholic subtypes, further investigation should investigate etiological factors that determine this subdivision.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33094457

RESUMO

This study presents a systematic on-site remediation case involving both heavy metal and organic contaminants in soil and groundwater in a historically industrial-used site in Shanghai, China. Lab-scale experiments and field tests were conducted to determine the optimum parameters for the removal of contaminants in soil and groundwater. It has been found that the remediation goal of hexavalent chromium in soil could be achieved with the mass content of added sodium hydrosulfite and ferrous sulfate reaching 3% + 6%. The total chromium in the groundwater was effectively removed, when the mass ratio of sodium metabisulfite was not less than 3 g/L, and the added quick lime made pH value not less than 9. The concentrations of arsenic and 1,2-dichloropropane in the groundwater decreased evidently after extraction and mixing of groundwater. The pH and calcium chloride dosage added should be larger than 9.5 and 5 g/L, respectively, to remove phosphate in groundwater. The removal efficiency of those contaminants was examined and evaluated after the on-site remediation. The results demonstrated that it was feasible to use the chemical reduction and solidification/stabilization methods for the on-site ex situ remediation of this site, which could be referenced for the realistic remediation of similar sites.

13.
Environ Microbiol ; 2020 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-33103811

RESUMO

The chemical synthesis intermediate 3,4-dichloronitrobenzene (3,4-DCNB) is an environmental pollutant. Diaphorobacter sp. strain JS3050 utilizes 3,4-DCNB as a sole source of carbon, nitrogen and energy. However, the molecular determinants of its catabolism are poorly understood. Here, the complete genome of strain JS3050 was sequenced and key genes were expressed heterologously to establish the details of its degradation pathway. A chromosome-encoded three-component nitroarene dioxygenase (DcnAaAbAcAd) converted 3,4-DCNB stoichiometrically to 4,5-dichlorocatechol, which was transformed to 3,4-dichloromuconate by a plasmid-borne ring-cleavage chlorocatechol 1,2-dioxygenase (DcnC). On the chromosome, there are also genes encoding enzymes (DcnDEF) responsible for the subsequent transformation of 3,4-dichloromuconate to ß-ketoadipic acid. The fact that the genes responsible for the catabolic pathway are separately located on plasmid and chromosome indicates that recent assembly and ongoing evolution of the genes encoding the pathway is likely. The regiospecificity of 4,5-dichlorocatechol formation from 3,4-DCNB by DcnAaAbAcAd represents a sophisticated evolution of the nitroarene dioxygenase that avoids misrouting of toxic intermediates. The findings enhance the understanding of microbial catabolic diversity during adaptive evolution in response to xenobiotics released into the environment. This article is protected by copyright. All rights reserved.

14.
Shock ; 54(5): 583-585, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33048866
15.
J Am Chem Soc ; 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33052647

RESUMO

We report a dual-interfacial engineering approach that uses a sub-20 nm polycrystalline MOF-74 shell as a transition phase to engineer the MOF-polymer interface. The application of a shell MOF layer divides the original single interface problem into two interfaces: MOF-MOF and MOF-polymer, which can be individually addressed. The greater external surface area created by the uneven MOF-74 shell containing high-density open metal sites allows the MOF to interact with 300% polymer at the interface compared to traditional MOF, thereby ensuring good interfacial compatibility. When applied on UiO-66-NH2, its respective mixed-matrix membranes exhibit a simultaneous increase of CO2/CH4 separation selectivity and CO2 permeability with increasing MOF loading, implying a defect-free interface. When applied on MOF-801, the mixed-matrix membranes exhibit an ethylene/ethane separation selectivity up to 5.91, a drastic 76% increase compared to that of the neat polymer owing to a "gas focusing" mechanism promoted by the preferred pore orientation in the MOF-74 layer. This represents one of the most selective ethylene/ethane separation membranes reported to date.

16.
Sci Adv ; 6(42)2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33067227

RESUMO

The Southern Ocean plays a crucial role in regulating atmospheric CO2 on centennial to millennial time scales. However, observations of sufficient resolution to explore this have been lacking. Here, we report high-resolution, multiproxy records based on precisely dated deep-sea corals from the Southern Ocean. Paired deep (∆14C and δ11B) and surface (δ15N) proxy data point to enhanced upwelling coupled with reduced efficiency of the biological pump at 14.6 and 11.7 thousand years (ka) ago, which would have facilitated rapid carbon release to the atmosphere. Transient periods of unusually well-ventilated waters in the deep Southern Ocean occurred at 16.3 and 12.8 ka ago. Contemporaneous atmospheric carbon records indicate that these Southern Ocean ventilation events are also important in releasing respired carbon from the deep ocean to the atmosphere. Our results thus highlight two distinct modes of Southern Ocean circulation and biogeochemistry associated with centennial-scale atmospheric CO2 jumps during the last deglaciation.

17.
Chem Commun (Camb) ; 2020 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-33107874

RESUMO

An electron donor-acceptor covalent organic framework (TTF-COF1) was constructed by the imine condensation of electron donor tetraformyl-tetrathiafulvalene (TTF-fo) and electron acceptor 2,6-diaminoanthraquinone (DAQ). TTF-COF1 has intramolecular charge transfer, offering capacitance of 752 F g-1 at 1 A g-1 and an energy density of 57 W h kg-1 at a power density of 858 W kg-1.

18.
Zootaxa ; 4838(4): zootaxa.4838.4.10, 2020 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-33056809

RESUMO

The genus Microstenus Szépligeti, 1916 (Hymenoptera: Ichneumonidae: Cryptinae) is newly recorded from China based on a new species, Microstenus rufithorax Sheng, Li Sun, sp. nov., collected from Guangxi Zhuang Autonomous Region, Oriental part of China. Illustrations of the new species are provided. A key to the world species of this genus is also provided.


Assuntos
Himenópteros , Animais , China
19.
Zhongguo Zhen Jiu ; 40(10): 1143-8, 2020 Oct 12.
Artigo em Chinês | MEDLINE | ID: mdl-33068362

RESUMO

The literature source, collection methods and stylistic layout, value and influence of 32 extraordinary points in Doutaishi Zhenjing (Master Dou's Canon of Acupuncture) were collected. The sources of the literature are extensive. The collection methods include 5 aspects, named inheritance, integration and repair; name rectification, identification and differentiation; new point explication on the base of extraordinary points; well arrangement of points and mutual use of three methods for stylistic layout; as well as integrative illustration with text and picture, and determined location. In reference to the holistic layout of name, location, techniques of acupuncture and moxibustion and indications of extraordinary points in Doutaishi Zhenjing (Master Dou's Canon of Acupuncture), it is the first time to make a standardized and unified collection of extraordinary points, which is valuable in the historical literature, the theoretic research and clinical practice of extraordinary points. It brings a great impact on the special articles or books after the Yuan dynasty and even the establishment of national standards at present.

20.
Sci Total Environ ; : 142745, 2020 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-33071130

RESUMO

In this work, magnetic lignin-based nanoparticles (M/ALFe) were developed and used to adsorb phosphorus to obtain phosphorus-saturated nanoparticles (M/ALFeP). The nanoparticles were then used as renewable slow-release compound fertilizers. First, aminated lignin was synthesized via Mannich reaction, and then Fe3O4 nanoparticles were loaded and Fe3+ was chelated on the aminated lignin to prepare M/ALFe. Finally, M/ALFeP were obtained after adsorption of phosphorus. The effects of nanoparticle dosage, solution pH and adsorption time on adsorption efficiency were determined. Adsorption isotherm and adsorption kinetics results suggested that the adsorption was coincided with the pseudo-second-order and Temkin model, respectively. The cumulative release of Fe and phosphorus from M/ALFeP increased gradually and reached to 67.2% and 69.1% in soil after 30 days, respectively. After the release of nutrients, M/ALFeP can be separated by a magnet with a high recovery ratio from water or soil and regenerated for phosphate recovery again. Therefore, the magnetic lignin-based nanoparticles have a promising application potential as an efficiently separated and renewable nanomaterial for removal of low concentration phosphate in wastewater treatment and as a slow-release fertilizer in sustainable agriculture.

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