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1.
J Orthop Translat ; 38: 106-116, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36381242

RESUMO

Background: Osteoarthritis (OA) is the most common degenerative joint disease, mainly affecting the elderly worldwide, for which the drug treatment remains a major challenge. Low-grade inflammation plays a pivotal role in OA onset and progression. Exploration of notable anti-inflammatory and disease-modifying drugs on human samples could facilitate the evaluation of therapeutic strategies for OA. Methods: The anti-inflammatory drug 5-aminosalicylic acid (5-ASA) is a first-line drug for ulcerative colitis (UC), however no study has explored the effects of 5-ASA on articular chondrocytes. In this work, both in vitro (chondrocyte pellets) and ex vivo (osteochondral explants) human inflammatory OA models were applied to evaluate the effects of 5-ASA. Results: In the inflammatory pellet model, 5-ASA remarkably downregulated the gene expression of interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) while upregulating proteoglycan 4 (PRG4) and cartilage oligomeric matrix protein (COMP) gene expression. Total glycosaminoglycan (GAG) synthesis by pellets was markedly increased in 5-ASA-treated groups compared with the inflammatory group. In conditioned medium, inflammatory mediators (IL-8, nitric oxide) were markedly inhibited upon 5-ASA treatment. Moreover, histological staining showed 5-ASA retained proteoglycan content and inhibited degradation of extracellular matrix (ECM) core components, aggrecan (ACAN) and collagen type II (COL2). In the inflammatory explant model, 5-ASA mitigated signs of OA development by reducing inflammatory mediators and GAG loss. Conclusions: These findings suggest that 5-ASA has anti-inflammatory and pro-anabolic effects on human chondrocyte pellet and osteochondral explant inflammatory OA models. The translational potential of this article: Disease-modifying OA drugs are an unmet clinical need for the treatment of OA. Our study explored and demonstrated the anti-inflammatory and protective effects of 5-ASA on in vitro and ex vivo human inflammatory OA models, showing its translational potential for OA treatment.

2.
Food Chem ; 403: 134314, 2023 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-36179632

RESUMO

Tropomyosin (TM) is a major shellfish allergen and a minor fish allergen. Different digestion profiles affect potential allergen anaphylaxis of protein. In this study, released peptides of fish-TM, shrimp-TM, and clam-TM by in vitro digestion of simulated gastric fluid (SGF), simulated intestinal fluid (SIF), and gastrointestinal (GI) were analyzed using sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) based proteomics. Results showed that digestion products of shrimp-TM yielded a lot of peptides matched T/B cell epitopes while core regions matched epitopes were distributed along the entire chain. Pepsin or trypsin-based digestion products of shrimp-TM presented many more peptides matched T/B cell epitopes compared with those of fish-TM and clam-TM. Besides, a differentiating peptide of VEKDKALSNAEGEVAAL (72-88) overlapped T/B cell epitopes could be used as a candidate peptide marker to identify tropomyosin allergen. These findings would supply new insight into the different allergenicity of tropomyosin.


Assuntos
Bivalves , Hipersensibilidade Alimentar , Penaeidae , Perciformes , Animais , Tropomiosina/metabolismo , Mapeamento de Epitopos , Epitopos de Linfócito B/metabolismo , Imunoglobulina E/metabolismo , Proteômica , Penaeidae/metabolismo , Alérgenos/metabolismo , Bivalves/genética , Bivalves/metabolismo , Perciformes/metabolismo , Peptídeos/metabolismo , Digestão
3.
Neural Regen Res ; 18(4): 889-894, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36204859

RESUMO

Exosome-derived long non-coding RNAs (lncRNAs) are extensively engaged in recovery and repair of the injured spinal cord, through different mechanisms. However, to date no study has systematically evaluated the differentially expressed lncRNAs involved in the development of spinal cord injury. Thus, the aim of this study was to identify key circulating exosome-derived lncRNAs in a rat model of spinal cord injury and investigate their potential actions. To this end, we established a rat model of spinal cord hemisection. Circulating exosomes were extracted from blood samples from spinal cord injury and control (sham) rats and further identified through Western blotting and electron microscopy. RNA was isolated from the exosomes and sequenced. The enrichment analysis demonstrated that there were distinctively different lncRNA and mRNA expression patterns between the two groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Gene Ontology (GO) functional analysis were performed to determine the possible involvements of upregulated and downregulated lncRNAs in various pathways and different biological processes, as well as their cellular locations and molecular functions. Furthermore, quantitative reverse transcription-polymerase chain reaction showed that the expression of five lncRNAs--ENSRN0T00000067908, XR_590093, XR_591455, XR_360081, and XR_346933--was increased, whereas the expression of XR_351404, XR_591426, XR_353833, XR_590076, and XR_590719 was decreased. Of note, these 10 lncRNAs were at the center of the lncRNA-miRNA-mRNA coexpression network, which also included 198 mRNAs and 41 miRNAs. Taken together, our findings show that several circulating exosomal lncRNAs are differentially expressed after spinal cord injury, suggesting that they may be involved in spinal cord injury pathology and pathogenesis. These lncRNAs could potentially serve as targets for the clinical diagnosis and treatment of spinal cord injury.

4.
Quant Imaging Med Surg ; 12(11): 5114-5128, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36330181

RESUMO

Background: Subphrenic jujube foreign body can cause perforation, abscess, peritonitis and other complications. Computed tomography (CT) is considered to be a sensitive tool for small or faintly opaque foreign body (e.g., jujube pits, toothpicks, fish bones, acrylics and plastics) detection. The present study aimed to investigate the clinical and imaging features of subphrenic jujube pits and explore the potential of CT for detecting and monitoring subphrenic jujube pits. Methods: Patients with subphrenic jujube pits who were treated at our institution were retrospectively reviewed along with published studies. A total of 10 types of commercially available jujube pits were analyzed with CT, then another 40 jujube pits (≥2.5 cm) were randomly selected and soaked in a series of solutions to mimic the gastrointestinal tract processes, following which CT was performed at serial time points with conventional and dual-energy protocols. Results: All jujube pits could be detected by CT, presenting spindle-shape high-density. The length of jujube pits based on clinical cases and that of the commercially available types were 1.38 to 3.50 cm and 1.35 to 3.95 cm, respectively. After analysis, the mean attenuation values derived from the clinical cases [77.67 Hounsfield unit (HU), range: -89.92 to 153.13 HU, SD 64.70 HU] were higher than those of the 10 commercially available types of jujube pits in boiled (73.57 HU, range: 2.29 to 94.96 HU, SD 20.48 HU) and raw state (-274.28 HU, range: -400.12 to -168.12 HU, SD 72.75 HU); statistically significant differences were found in mean attenuation values between raw jujube pits and boiled jujube pits (P<0.05). After soaking, the radiodensity of raw jujube pits showed an upward trend over immersion time, and water (-hydroxyapatite) overlay images enhanced the visualization of jujube pit water content as the percentage of blue area increased over time. Conclusions: CT plays an important role in evaluating and tracing subphrenic jujube pits.

5.
Front Genet ; 13: 991606, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36330447

RESUMO

Meat quality is highly influenced by the kind of muscle fiber, and it can be significantly improved by increasing the percentage of slow-twitch fibers. It is still not known which genes control the formation of muscle fibers or how those genes control the process of forming in sheep until now. In this study, we used high-throughput RNA sequencing to assess the expression profiles of coding and noncoding RNAs in muscle tissue of Tan sheep and Dorper sheep. To investigate the molecular processes involved in the formation of muscle fibers, we collected two different muscle tissues, longissimus dorsi and biceps femoris, from Tan sheep and Dorper sheep. The longissimus dorsi of Tan sheep and Dorper sheep displayed significantly differential expression levels for 214 lncRNAs, 25 mRNAs, 4 miRNAs, and 91 circRNAs. Similarly, 172 lncRNAs, 35 mRNAs, 12 miRNAs, and 95 circRNAs were differentially expressed in the biceps femoris of Tan sheep and Dorper sheep according to the expression profiling. GO and KEGG annotation revealed that these differentially expressed genes and noncoding RNAs were related to pathways of the formation of muscle fiber, such as the Ca2+, FoxO, and AMPK signaling pathways. Several key genes are involved in the formation of muscle fibers, including ACACB, ATP6V0A1, ASAH1, EFHB, MYL3, C1QTNF7, SFSWAP, and FBXL5. RT-qPCR verified that the expression patterns of randomly selected differentially expressed transcripts were highly consistent with those obtained by RNA sequencing. A total of 10 lncRNAs, 12 miRNAs, 20 circRNAs, and 19 genes formed lncRNA/circRNA-miRNA-gene networks, indicating that the formation of muscle fiber in Tan sheep is controlled by intricate regulatory networks of coding and noncoding genes. Our findings suggested that specific ceRNA subnetworks, such as circ_0017336-miR-23a-FBXL5, may be critical in the regulation of the development of muscle fibers, offering a valuable resource for future study of the development of muscle fibers in this animal species. The findings increase our understanding of the variety in how muscle fibers originate in various domestic animals and lay the groundwork for future research into new systems that regulate the development of muscle.

6.
Front Oncol ; 12: 1004690, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36330478

RESUMO

Objective: To improve understanding of diffusion weighted imaging (DWI) characteristic of MRI and clinical variables, further optimize the Bosniak classification for diagnosis of cystic renal masses (CRMs). Methods: This study retrospectively analyzed 130 CRMs in 125 patients with CT or MRI, including 87 patients with DWI (b = 600, 1000 s/mm2). Clinical variables and histopathological results were recorded. Two radiologists in consensus analyzed images of each lesion for the size, thickness of wall, number of septum, enhancement of wall/septum, wall nodule, signal intensity on DWI, calcification, and cyst content. Clinical variables, CT and MRI image characteristics were compared with pathology or follow-up results to evaluate the diagnostic performance for CRMs. Results: Of the 130 lesions in 125 patients, histological analysis reported that 36 were malignant, 38 were benign, and no change was found in 56 followed-up lesions (mean follow-up of 24 months). The incidences of cystic wall thickened, more septa, measurable enhancement of wall/septum, nodule(s) on CT/MRI, and high signal intensity on DWI were significantly higher in malignant than in benign CRMs (CT: p = 0.005, p < 0.001, p < 0.001, p < 0.001, p < 0.001; MRI: p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001). Combination of MRI including DWI features with CT findings showed the highest area under ROC curve (0.973) in distinguishing benign and malignant CRMs. Conclusions: Incorporating DWI characteristic of CRMs into Bosniak classification helps to improve diagnostic efficiency.

7.
Sheng Li Xue Bao ; 74(5): 827-836, 2022 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-36319105

RESUMO

Butyrate, normally produced by probiotics in the gut, not only provides energy for cells, but also changes the phosphorylation, acetylation and methylation levels of many proteins in cells. As a result, it affects the expression of many genes and the transmission of cell signals. Through G protein-coupled receptors, butyrate promotes the secretion of intestinal mucus and the formation of epithelial barriers, and attenuates the impacts of the pathogenic bacteria and their metabolites on human body. The Toll-like receptors (TLRs) are a group of pattern recognition receptors, and their activation causes the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus and eventually leads to expression and secretion of various pro-inflammatory factors and chemokines. The expression of TLRs is also involved in the pathogenesis of some inflammatory diseases and tumors. The purpose of this review is to summarize the effects of butyrate on TLRs and their downstream signaling pathways. We not only summarized the production of butyrate, the expression of TLRs and the influence of their interaction on the body under the conditions of inflammation and tumor, but also discussed the potential role of butyrate as a bacterial metabolite in the treatments of some human diseases.


Assuntos
Butiratos , Receptores Toll-Like , Humanos , Acetilação , Fosforilação , Inflamação
8.
IEEE Trans Image Process ; 31: 7006-7019, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36322492

RESUMO

Quantization is a promising technique to reduce the computation and storage costs of DNNs. Low-bit ( ≤ 8 bits) precision training remains an open problem due to the difficulty of gradient quantization. In this paper, we find two long-standing misunderstandings of the bias of gradient quantization noise. First, the large bias of gradient quantization noise, instead of the variance, is the key factor of training accuracy loss. Second, the widely used stochastic rounding cannot solve the training crash problem caused by the gradient quantization bias in practice. Moreover, we find that the asymmetric distribution of gradients causes a large bias of gradient quantization noise. Based on our findings, we propose a novel adaptive piecewise quantization method to effectively limit the bias of gradient quantization noise. Accordingly, we propose a new data format, Piecewise Fixed Point (PWF), to present data after quantization. We apply our method to different applications including image classification, machine translation, optical character recognition, and text classification. We achieve approximately 1.9 âˆ¼ 3.5× speedup compared with full precision training with an accuracy loss of less than 0.5%. To the best of our knowledge, this is the first work to quantize gradients of all layers to 8 bits in both large-scale CNN and RNN training with negligible accuracy loss.

9.
Comput Struct Biotechnol J ; 20: 6078-6086, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36373151

RESUMO

SARS-CoV-2 variants often include surface mutations in the Spike protein that are important for viruses to recognize host receptors and evade antibody neutralization. The Spike protein also has mutations in the interior of the protein likely to affect the Spike protein S1 - S2 subunit's separation propensity, the most important of which is the D614G mutation. Remarkably, the Omicron variant contains a large number of internal mutations at the S2: S1 interface, which have not been investigated yet. In this study, we examined the effects of such interfacial mutations on the S2: S1 and subunit domain interactions and on the subunit's dissociation process. We found that the interaction with S2 is mainly contributed by the three encapsulation domains, named INT, ED1 and ED2 of S1, which are sandwiched between the S1 RBD and N-terminal NTD domain. We found that D614 is the strongest contributor for the S2: S1 interaction which is greatly weakened by the D614G mutation. Surprisingly, we found that, mutations T547K, H655Y, N764K, N856K, N969K, L981F in the Omicron variant largely enhance the S2: ED1 interaction, partially compensating the loss of S2: ED2 interaction due to the D614G mutation. Lastly, these results, together with biological considerations, allow us to suggest that in addition to the binding strength of between the RBD and ACE2, the stability of the Spike protein and the propensity of Spike protein S2: S1 separation are critical factors which likely exist in a balance for a particular infectivity and pathogenicity of the virus.

10.
Sci Total Environ ; : 160146, 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36375554

RESUMO

Several pyrethroids (such as flumethrin and fluvalinate) with low toxicity to honey bees and comparable high toxicity to mites are used worldwide as acaricides. However, flumethrin has been used for a long time in colonies to control Varroa destructor and the honey bees might be exposed to flumethrin cumulatively, which could affect the health of honey bee colonies. This study evaluated the potential adverse effects of direct flumethrin exposure on worker bees under laboratory and colony conditions. Under laboratory conditions, downregulation of genes related to immune was observed when worker bees were exposed to flumethrin above 1/16 LD50; at levels above 1/8 LD50, olfactory learning was impaired, and genes related to learning memory were downregulated; and at >1/4 LD50, their lifespan was shortened. Monitoring with radio frequency identification (RFID) revealed that worker bees in a colony exposed to flumethrin above 1/8 LD50 had a shortened lifespan and reduced foraging ability. When worker bees are exposed to >1/4 LD50 of flumethrin, it can lead to excessive rest day behavior. These results indicate that applying flumethrin in colonies may pose a severe health risk to honey bees and reveal the urgent need to develop non-toxic and highly effective acaricides.

12.
Org Lett ; 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36367968

RESUMO

A copper-catalyzed sulfinyl cross-coupling reaction of sulfinamides with aldehyde-derived N-tosylhydrazones is described. This approach enables facile access for the construction of structurally diverse sulfoxides via novel and efficient S-N/S-C bond interconversions, features broad substrate scope, and accommodates various functional groups as well as pharmacophores. Moreover, the given sulfinyl cross-coupling reaction could be scaled up to the gram scale and carried out in a one-pot fashion directly from aldehydes. The broad utility of produced sulfoxides is demonstrated by further transformations. A preliminary mechanistic investigation was performed, which disclosed possible reaction pathways.

13.
J Asian Nat Prod Res ; : 1-9, 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36369722

RESUMO

An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible ring-opening mechanism of 6,19-epoxy bridge in compound 7 was first proposed and the structures of intermediates were supported by the LC-MS analysis of the reaction mixture.

14.
Ann Hematol ; 101(12): 2731-2741, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36318288

RESUMO

The use of Bcl-2 inhibitor Venetoclax (VEN) combined with hypomethylating agents or chemotherapy has shown efficacy in treating acute myeloid leukemia (AML) as frontline treatment and for relapse, allowing more patients to bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the influence of VEN-based therapy on the prognosis of subsequent allogeneic HSCT remains unknown. We retrospectively collected data from patients who proceeded to allo-HSCT between November 2018 and November 2020 after VEN-based therapy at five transplant centers in Zhejiang Province, China. A total of 39 patients were analyzed. Thirty-one patients were diagnosed with AML (28 de novo, 3 secondary to MDS), 6 with MDS, and 2 with CMML. The majority (74.4%) of patients received VEN-based therapy for the treatment of relapse (38.5%) or refractory disease (35.9%); 5 (12.8%) received it as an initial treatment, and 5 (12.8%) patients who were already in complete remission (CR) received VEN for further consolidation or deep remission before HSCT. Twenty-seven (69.2%) patients were in CR at the time of HSCT. Day + 100 cumulative incidences of grade I-IV acute graft-versus-host disease (aGVHD) and grade II-IV aGVHD were 43.6% and 15.4%, respectively. Of 34 evaluable patients, 6.4% and 25.6% developed chronic GVHD at 1 year and 2 years. The 100-day cytomegalovirus (CMV) reactivation occurred in 76.3% of patients and Epstein-Barr virus (EBV) reactivation occurred in 29.7% of patients. With a median follow-up of 14.7 months, overall survival, progression-free survival, relapse, and non-relapse mortality incidence at 1 year were 75.5%, 61.6%, 16.7%, and 21.7%, respectively. Both univariate and multivariate analysis revealed that relapsed/refractory (R/R) disease was associated with inferior PFS (HR 4.849, 95% CI 1.009-23.30; p = 0.049). Prior poor response to VEN was found to be a significant factor predicting higher risk of relapse (HR 4.37, 95% CI 1.130-16.9; p = 0.033). Our results showed that VEN-based regimen therapy followed by allo-HSCT in AML patients is feasible and does not increase the risk of transplant-related mortality and toxicity.


Assuntos
Infecções por Vírus Epstein-Barr , Doença Enxerto-Hospedeiro , Transplante de Células-Tronco Hematopoéticas , Leucemia Mieloide Aguda , Humanos , Estudos Retrospectivos , Infecções por Vírus Epstein-Barr/complicações , Herpesvirus Humano 4 , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Leucemia Mieloide Aguda/tratamento farmacológico , Leucemia Mieloide Aguda/complicações , Doença Enxerto-Hospedeiro/etiologia , Recidiva
15.
Neuroscience ; 2022 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-36341725

RESUMO

Cerebral ischemia-reperfusion injury (CI/RI) injury is a common feature of ischemic stroke which occurs when the blood supply is restored after a period of ischemia in the brain. Reduced blood-flow to the brain during CI/RI compromises neuronal cell health as a result of mitochondrial dysfunction, oxidative stress, cytokine production, inflammation and tissue damage. Reperfusion therapy during CI/RI can restore the blood flow to ischemic regions of brain which are not yet infarcted. The long-term goal of CI/RI therapy is to reduce stroke-related neuronal cell death, disability and mortality. A range of drug and interventional therapies have emerged that can alleviate CI/RI mediated oxidative stress, inflammation and apoptosis in the brain. Herein, we review recent studies on CI/RI interventions for which a mechanism of action has been described and the potential of these therapeutic modalities for future use in the clinic.

16.
Front Oncol ; 12: 955150, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36353544

RESUMO

Although vaginal microbiota (VM) may interact with human papillomavirus (HPV) infection and clearance, longitudinal data remain very limited. We aimed to investigate the association between VM at baseline and the clearance of high-risk HPV (HR-HPV) infection within 12 months. Cervical swabs were collected at diagnosis from 85 patients with HR-HPV infection and histologically confirmed cervical lesions, including cervicitis, low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion. Microbiome analysis was performed using 16S rRNA gene sequencing. Among the 73 women included in the analyses, HPV clearance was observed in 58.9% of the patients within 12 months. No significant difference was observed between the HPV-cleared and HPV-uncleared groups regarding age, disease stage, HPV subtype, VM community state types, and VM diversity (α and ß). Women with the depletion of enterococcus ASV_62 and enrichment in Lactobacillus iners at baseline were less likely to have HPV clearance at month 12. Further analysis revealed a significant negative association between high abundance of L. iners and HPV clearance in patients who received non-operative treatment (OR = 3.94, p = 0.041), but not in those who received operative treatment (OR = 1.86, p = 0.660). Our findings provide new evidence for the potential role of VM in the persistent HR-HPV infections.

17.
Am J Infect Control ; 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36375705

RESUMO

OBJECTIVE: To evaluate potential viral contamination on the surfaces of personal protective equipment (PPE) in COVID-19 wards. METHODS: Face shields, gloves, the chest area of the PPE and shoe soles were sampled at different time points. The samples were tested for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by PCR, and the cycle threshold (CT) values were recorded for quantification. The positive rates of different types of PPE samples and their CT values and the CT values of specimens from different spots were compared. RESULTS: The positive rate was 74.7% (239/320) for all PPE specimens and was highest for gloves (96.25%, 77/80) and shoe soles (92.5%, 74/80). The CT values of the samples were ranked in the following order: face shields > chests > gloves > shoe soles (37.08±1.38, 35.48±2.02, 34.17±1.91 and 33.52±3.16, respectively; P for trend <0.001). After disinfection, the CT values of shoe soles decreased significantly compared with before disinfection (32.78±3.47 vs. 34.3±2.61, P=0.037), whereas no significant effect of disinfection on the CT values of face shields, chests and gloves was observed. After disinfection (disinfection period), the CT values of specimens collected from shoe soles gradually increased; before disinfection (nondisinfection period), the CT values of shoe sole specimens were all less than 35. CONCLUSION: SARS-CoV-2 can attach to the surfaces of the PPE of healthcare professionals working in a designated hospital, especially the soles of shoes and undisinfected gloves. Shoe soles had the highest SARS-CoV-2 loads among all tested PPE items.

18.
RSC Adv ; 12(49): 31900-31910, 2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36380948

RESUMO

Biochar reinforced advanced nanocomposites are of interest to a wide circle of researchers. Herein, we describe a novel MOF-derived reinforced cow dung biochar composite, which was prepared by a one-step hydrothermal method to form the MOF MIL-125(Ti) onto a nitrogen and sulfur co-doped bio-carbon (NSCDBC). The UV-vis diffuse reflectance spectrum of NSCDBC/MIL-125(Ti) exhibits an extension of light absorption in the visible region (360-800 nm), indicating its higher visible light capture capacity relative to pure MIL-125(Ti). The photocatalytic activity results show that all the NSCDBC/MIL-125(Ti) composite samples, namely NSCM-5, NSCM-10, NSCM-20 and NSCM-30 display good performance in the removal of tetracycline hydrochloride compared to pure MIL-125(Ti). Among them, NSCM-20 exhibits the highest catalytic activity with a removal rate of 94.62%, which is attributed to the excellent adsorption ability of NSCDBC and the ability to inhibit the complexation of photogenerated electron-hole pairs. Photoluminescence verifies that the loading of biochar successfully enhances the separation of photogenerated electron-hole pairs. Subsequently, the active species in the photocatalytic process are identified by using electron spin resonance spin-trap techniques and free radical trapping experiments. Finally, the possible reaction mechanism for the photocatalytic process is revealed. These results confirm that NSCDBC/MIL-125(Ti) is a potentially low-cost, green photocatalyst for water quality improvement.

19.
J Clin Ultrasound ; 2022 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-36385468

RESUMO

OBJECTIVE: To evaluate carotid artery elasticity in long-term drinkers with varying degrees of alcoholic fatty liver disease (AFLD) by shear wave elastography (SWE). METHODS: Of the 92 drinkers with alcohol drinking for greater than or equal to 5 years, were fell into three groups depending on the liver ultrasound results: group B (without AFLD), group C (with mild AFLD), and group D (moderate-to-severe AFLD). Another 32 healthy adults were selected as the control group (group A). All participants had no significant carotid plaque. Gray scale ultrasound and color doppler ultrasound were used to obtain the left common carotid peak systolic velocity (PSV), carotid diastolic internal diameter (Dd ), carotid intima-media thickness (IMT), carotid systolic internal diameter (Ds ) and the stiffness coefficient (ß). Mean values of mean elastic modulus (MEmean ), minimum elastic modulus (MEmin ), and maximum elastic modulus (MEmax ) of the anterior wall of the left common carotid artery at end-diastole were measured by SWE. RESULTS: Dd , Ds , and PSV among the four groups showed no differences. (all P > 0.05). Compared with groups A and B, MEmin , MEmax , and MEmean were significantly higher in group C (all P < 0.05), while IMT and ß were not statistically different (all P > 0.05). MEmean , MEmin , MEmax , IMT, and ß were significantly higher in group D compared with the other three groups (all P < 0.05). No significant differences were observed in IMT, ß, MEmean , MEmax , and MEmin between groups A and B (all P > 0.05). CONCLUSIONS: Shear wave elastography can provide a quantitative evaluation for the carotid artery elasticity in long-term drinkers with varying degrees of AFLD.

20.
Materials (Basel) ; 15(21)2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36363326

RESUMO

Rough- and intermediate-rolled composite billets and finished clad rebars were cut using flying shears. The law of metal rheology and the mechanism of composite interface generation during clad rebar formation were then investigated using metallographic microscopy, electron backscatter diffraction, and scanning electron microscopy. The radial deformation trend of the clad rebars was greater than that of HRB400 rebars and "ears" were more likely to appear during the rolling process. The widths of the decarburization and composite zones and diffusion distances of each element decreased as the cumulative reduction rate increased. Furthermore, as deformation increased, the number of oxides on the composite interface significantly decreased, the proportion of recrystallized grains increased, and the grains became more refined. These changes led to increases in the bond and tensile strengths of the composite interface. According to the research above, the pass filling degree should be within 0.85-0.9 and the cumulative reduction rate should be over 80% when rolling clad rebars.

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