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1.
IEEE Trans Vis Comput Graph ; 26(1): 811-821, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31443003

RESUMO

OD bundling is a promising method to identify key origin-destination (OD) patterns, but the bundling can mislead the interpretation of actual trajectories traveled. We present OD Morphing, an interactive OD bundling technique that improves geographical faithfulness to actual trajectories while preserving visual simplicity for OD patterns. OD Morphing iteratively identifies critical waypoints from the actual trajectory network with a min-cut algorithm and transitions OD bundles to pass through the identified waypoints with a smooth morphing method. Furthermore, we extend OD Morphing to support bundling at interaction speeds to enable users to interactively transition between degrees of faithfulness to aid sensemaking. We introduce metrics for faithfulness and simplicity to evaluate their trade-off achieved by OD morphed bundling. We demonstrate OD Morphing on real-world city-scale taxi trajectory and USA domestic planned flight datasets.

2.
Sci Total Environ ; 698: 134336, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31783440

RESUMO

Invasive species are increasingly replacing native species, especially in anthropogenically transformed or polluted habitats. This opens the possibility to use invasive species as indicator taxa for the biological assessment of pollution. Integrated biological assessment, however, additionally relies on the application of multiple approaches to quantify physiological or cytogenetic responses to pollution within the same focal species. This is challenging when species are restricted to either polluted or unpolluted sites. Here, we make use of a small group of neotropical livebearing fishes (family Poeciliidae) for the integrated biological assessment of water quality. Comparing urban and suburban stream sections that receive varying degrees of pollution from industrial and domestic waste waters in and around the Brazilian city of Uberlândia, we demonstrate that two members of this family may indeed serve as indicators of water pollution levels. The native species Phalloceros caudimaculatus appears to be replaced by invasive guppies (Poecilia reticulata) at heavily polluted sites. Nevertheless, we demonstrate that both species could be used for the assessment of bioaccumulation of heavy metals (Pb, Cu, and Cr). Ambient (sediment) concentrations predicted concentrations in somatic tissue across species (R2-values between 0.74 and 0.96). Moreover, we used cytogenetic methods to provide an estimate of genotoxic effects of water pollution and found pollution levels (multiple variables, condensed into principal components) to predict the occurrence of nuclear abnormalities (e.g., frequencies of micro-nucleated cells) across species (R2 between 0.69 and 0.83). The occurrence of poeciliid fishes in urban and polluted environments renders this family a prime group of focal organisms for biological water quality monitoring and assessment. Both species could be used interchangeably to assess genotoxic effects of water pollution, which may facilitate future comparative analyses over extensive geographic scales, as members of the family Poeciliidae have become invasive in tropical and subtropical regions worldwide.

3.
Methods Mol Biol ; 2047: 363-375, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31552665

RESUMO

The dynamic expression pattern analysis provides the primary information of gene function. Differences of the RNA and/or protein location will provide valuable information for gene expression regulation. Generally, in situ hybridization (ISH) and immunohistochemistry (IHC) are two main techniques to visualize the locations of gene transcripts and protein products in situ, respectively. Here we describe the protocol for the whole brain dissection, the in situ hybridization, and the immunostaining of the developing Xenopus brain sections. Additionally, we point out the modification of in situ hybridization for microRNA expression detection.

4.
Neuron ; 2019 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-31786011

RESUMO

How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that depleting neuronal lipin1, a key enzyme controlling the balanced synthesis of glycerolipids through the glycerol phosphate pathway, enhanced axon regeneration after optic nerve injury. Axotomy elevated lipin1 in retinal ganglion cells, which contributed to regeneration failure in the CNS by favorably producing triglyceride (TG) storage lipids rather than phospholipid (PL) membrane lipids in neurons. Regrowth induced by lipin1 depletion required TG hydrolysis and PL synthesis. Decreasing TG synthesis by deleting neuronal diglyceride acyltransferases (DGATs) and enhancing PL synthesis through the Kennedy pathway promoted axon regeneration. In addition, peripheral neurons adopted this mechanism for their spontaneous axon regeneration. Our study reveals a critical role of lipin1 and DGATs as intrinsic regulators of glycerolipid metabolism in neurons and indicates that directing neuronal lipid synthesis away from TG synthesis and toward PL synthesis may promote axon regeneration.

5.
Oncol Rep ; 2019 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-31789411

RESUMO

Nicotinic acetylcholine receptor (nAChR) subunit α5 (α5­nAChR) is involved in tumor cell proliferation, inhibition of apoptosis, progression of metastasis, and induction of angiogenesis in certain solid tumors. However, the role of α5­nAChR in prostate cancer cell growth and metastasis is unclear. In the present study, the role of α5­nAChR in cell proliferation, migration, invasion and apoptosis was investigated by silencing the expression levels of α5­nAChR in the prostate cancer cell lines DU145 and PC3. A siRNA oligonucleotide targeting α5­nAChR was designed. The cell proliferation of DU145 and PC3 cell lines was analyzed by the Cell Counting Kit­8 (CCK­8) assay. Cell migratory and invasive activities were determined using wound healing and Transwell assays, respectively. Western blot analysis was used to quantify α5­nAChR, p­AKT and p­ERK1/2 levels in DU145 and PC3 cells. Knockdown of α5­nAChR was associated with decreased cell proliferation, migration, invasion and increased apoptosis. In addition, decreased phosphorylation levels of AKT and ERK1/2 were revealed following α5­nAChR knockdown in DU145 and PC3 cells compared with those observed in the scramble control samples. The expression levels of the apoptosis­related proteins were altered following silencing of α5­nAChR. In summary, the data indicated that α5­nAChR was involved in the proliferation and invasion of human prostate cancer cells.

6.
ACS Nano ; 2019 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-31789497

RESUMO

Structural asymmetry of materials plays a crucial role in developing multipurpose devices. Layered metallic transition metal dichalcogenides (MTMDCs) have been proposed as promising materials in electronics. However, they are still subject to native surface oxidation, limiting their practical applications. Combination of surface protection and native surface oxidation of MTMDCs will create asymmetric structures for devices but has yet to be explored. Here, we report a bifunctional NbS2-based vertical heterostructure derived from epitaxially grown NbS2 on MoS2 followed by a natural oxidation (MoS2-NbS2-NbOx), which simultaneously exhibits both high-efficiency tunneling conductive and memristive surfaces. With the tunneling conductive surface, the heterostructure functions as nearly ohmic contact electrodes with a two-dimensional (2D) channel in lateral transistors, delivering an enhanced mobility ∼140 times higher than that of the exfoliated NbS2-contacted device. With the memristive surface, the heterostructure can be used to build high-performance lateral or vertical memristors with low working voltages and synaptic functions. By combining both types of surfaces, a memristor array for nonvolatile memory is further developed. Moreover, the memristors show a good endurance for 2000 cycles of bending as flexible devices. The bifunctional heterostructure based on NbS2 offers a strategy toward the future applications of layered metallic materials.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31753747

RESUMO

OBJECTIVES: Stroke volume variation (SVV) has been used to predict fluid responsiveness. The authors hypothesized the changes in SVV induced by passive leg raising (PLR) might be an indicator of fluid responsiveness in patients with protective ventilation after cardiac surgery. DESIGN: A prospective single-center observational study. SETTING: A single cardiac surgery intensive care unit at a tertiary hospital. PARTICIPANTS: A total of 123 patients undergoing cardiac surgery with hemodynamic instability. Tidal volume was set between 6 and 8 mL/kg of ideal body weight. INTERVENTIONS: PLR maneuver, fluid challenge. MEASUREMENTS AND MAIN RESULTS: SVV was continuously recorded using pulse contour analysis before and immediately after a PLR test and after fluid challenge (500 mL of colloid given over 30 min). Sixty-three (51.22%) patients responded to fluid challenge, in which PLR and fluid challenge significantly increased the SV and decreased the SVV. The decrease in SVV induced by PLR was correlated with the SV changes induced by fluid challenge. A 4% decrease in the SVV induced by PLR-discriminated responders to fluid challenge with an area under the curve of 0.90. The gray zone identified a range of SVV changes induced by PLR (between -3.94% and -2.91%) for which fluid responsiveness could not be predicted reliably. The gray zone included 15.45% of the patients. The SVV at baseline predicted fluid responsiveness with an area under the curve of 0.72. CONCLUSIONS: Changes in the SVV induced by PLR predicted fluid responsiveness in cardiac surgical patients with protective ventilation.

8.
Phytother Res ; 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31667906

RESUMO

Type 1 diabetes mellitus (T1DM) is a systemic disease and one classical type of total DM. Bilobalide (BB) is constituted of EGb 761. Our purpose was identifying the role of BB in TIDM in the current study. MIN6 cells were treated by TNF-α; then, viability, apoptosis, and insulin secretion were assessed by performing Cell Counting Kit-8 assay, flow cytometry, glucose-stimulated insulin secretion assay, and western blot. The effects of BB were assessed to identify its function. Further, the above mentioned parameters were reassessed when silencing miR-153. TNF-α declined viability and insulin secretion as well as raised apoptosis and inducible nitric oxide synthase (iNOS) expression in MIN6 cells. BB alleviated the apoptosis and dysfunction induced by TNF-α. MiR-153 expression was elevated by BB when induced by TNF-α. Increase of viability and insulin secretion as well as decline of apoptosis and iNOS induced by BB treatment was alleviated by silencing miR-153. The rates of p/t-p70S6K, p/t-mammalian target of rapamycin (mTOR) and p/t-adenosine monophosphate-activated protein kinase (AMPK) were raised by BB and suppressed by silencing miR-153 under TNF-α induced condition. BB raised viability and insulin secretion, declined apoptosis and iNOS expression by up-regulating miR-153. Furthermore, BB activated AMPK/mTOR pathway by up-regulating miR-153.

9.
J Invest Dermatol ; 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31669413

RESUMO

Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier permeability and renders mice susceptible to environmental bacterial infection and inflammatory dermatitis. It had been unclear how lack of ZDHHC13 proteins resulted in cutaneous abnormalities. In this study, we first demonstrate that enzymatic palmitoylation activity, rather than protein scaffolding, by ZDHHC13 is essential for skin barrier integrity, showing that knock-in mice bearing an enzymatically dead DQ-to-AA ZDHHC13 mutation cyclically lost their hair after weaning, recapitulating knock-out phenotypes of skin inflammation and dermatitis. To establish the ZDHHC13 substrates responsible for skin barrier development, we employed quantitative proteomic approaches to identify protein molecules whose palmitoylation is tightly controlled by ZDHHC13. We identified over 300 candidate proteins that could be classified into four biological categories: immunological disease, skin development and function, dermatological disease, and lipid metabolism. Palmitoylation of three of these candidates-loricrin, peptidyl arginine deiminase type III and keratin fiber crosslinker transglutaminase 1-by ZDHHC13 was confirmed by biochemical assay. Palmitoylation was critical for in vivo protein stability of the latter two candidates. Our findings reveal the importance of protein palmitoylation in skin barrier development, partly by promoting envelope protein crosslinking and the filaggrin processing pathway.

10.
Proc Natl Acad Sci U S A ; 116(49): 24639-24650, 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31754024

RESUMO

Proteasome-mediated degradation of intracellular proteins is essential for cell function and survival. The proteasome-binding protein PI31 (Proteasomal Inhibitor of 31kD) promotes 26S assembly and functions as an adapter for proteasome transport in axons. As localized protein synthesis and degradation is especially critical in neurons, we generated a conditional loss of PI31 in spinal motor neurons (MNs) and cerebellar Purkinje cells (PCs). A cKO of PI31 in these neurons caused axon degeneration, neuronal loss, and progressive spinal and cerebellar neurological dysfunction. For both MNs and PCs, markers of proteotoxic stress preceded axonal degeneration and motor dysfunction, indicating a critical role for PI31 in neuronal homeostasis. The time course of the loss of MN and PC function in developing mouse central nervous system suggests a key role for PI31 in human neurodegenerative diseases.

11.
Artigo em Inglês | MEDLINE | ID: mdl-31746587

RESUMO

Recent developments in various technologies, such as hybrid electric vehicles and pulsed power systems, have challenged researchers to discover affordable, compact, and super-functioning electric energy storage devices. Among the existing energy storage devices, polymer nanocomposite film capacitors are a preferred choice due to their high power density, fast charge and discharge speed, high operation voltage, and long service lifetime. In the past several years, they have been extensively researched worldwide, with 0D, 1D, and 2D nanofillers being incorporated into various polymer matrixes. However, 1D nanofillers appeared to be the most effective in producing large dipole moments, which leads to a considerably enhanced dielectric permittivity and energy density of the nanocomposite. As such, this Review focuses on recent advances in polymer matrix nanocomposites using various types of 1D nanofillers, i.e., linear, ferroelectric, paraelectric, and relaxor-ferroelectric for energy storage applications. Correspondingly, the latest developments in the nanocomposite dielectrics with highly oriented, surface-coated, and surface-decorated 1D nanofillers are presented. Special attention has been paid to identifying the underlying mechanisms of maximizing dielectric displacement, increasing dielectric breakdown strength, and enhancing the energy density. This Review also presents some suggestions for future research in low-loss, high energy storage devices.

12.
Biomed Res Int ; 2019: 7521715, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31737677

RESUMO

This study aimed to investigate the effects of leucine (Leu) on the synthesis and secretion of digestive enzymes in cultured pancreatic tissue of dairy goats and on the signaling molecules. Fresh pancreatic tissue from dairy goats was cut into approximately 2 mm × 2 mm pieces and incubated in oxygenated Krebs-Ringer bicarbonate buffer containing 0 (the control), 0.40, 0.80, or 1.60 mM Leu at 39°C in a CO2 incubator for 180 min. The results showed that Leu increased the release of α-amylase, trypsin, and chymotrypsin in the buffer and tissue, as well as the total activity (P < 0.05), especially at 0.40 and 0.80 mM. Compared with the control, 1.60 mM Leu increased the release of α-amylase and the total activity of trypsin and chymotrypsin (P < 0.05) but had no effect on the tissue concentration of α-amylase, trypsin, and chymotrypsin or the total activity of α-amylase (P > 0.05). Leu improved the mRNA expression of α-amylase, trypsin, and chymotrypsin (P < 0.05), especially at 0.80 and 1.60 mM. The activity and mRNA expression of lipase were not affected (P > 0.05). Compared with the control, 0.40 and 0.80 mM Leu increased the expression of the γ isoform of 4EBP1 (P < 0.05), implying increased phosphorylation of 4EBP1. Leu increased the phosphorylation of S6K1 (P < 0.05). Compared with the control, 0.40 and 0.80 mM Leu decreased the eEF2 phosphorylation level (P < 0.05). Conclusively, these results suggested that Leu could regulate the synthesis of pancreatic enzymes by increasing the mRNA expression and phosphorylation level of protein factors in the mammalian target of rapamycin pathway and the optimal Leu level in this experiment was 0.80 mM.

13.
Nat Commun ; 10(1): 5384, 2019 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-31772158

RESUMO

The emergence of wearable electronics puts batteries closer to the human skin, exacerbating the need for battery materials that are robust, highly ionically conductive, and stretchable. Herein, we introduce a supramolecular design as an effective strategy to overcome the canonical tradeoff between mechanical robustness and ionic conductivity in polymer electrolytes. The supramolecular lithium ion conductor utilizes orthogonally functional H-bonding domains and ion-conducting domains to create a polymer electrolyte with unprecedented toughness (29.3 MJ m-3) and high ionic conductivity (1.2 × 10-4 S cm-1 at 25 °C). Implementation of the supramolecular ion conductor as a binder material allows for the creation of stretchable lithium-ion battery electrodes with strain capability of over 900% via a conventional slurry process. The supramolecular nature of these battery components enables intimate bonding at the electrode-electrolyte interface. Combination of these stretchable components leads to a stretchable battery with a capacity of 1.1 mAh cm-2 that functions even when stretched to 70% strain. The method reported here of decoupling ionic conductivity from mechanical properties opens a promising route to create high-toughness ion transport materials for energy storage applications.

14.
Acta Biomater ; 2019 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-31783141

RESUMO

Engineering of materials consisting of hypertrophic cartilage, as physiological template for de novo bone formation through endochondral ossification (ECO), holds promise as a new class of biological bone substitutes. Here, we assessed the efficiency and reproducibility of bone formation induced by the combination of ceramic granules with fractionated human adipose tissue ("nanofat"), followed by in vitro priming to hypertrophic cartilage. Human nanofat was mixed with different volumetric ratios of ceramic granules (0.2-1 mm) and cultured to sequentially induce proliferation (3 weeks), chondrogenesis (4 weeks), and hypertrophy (2 weeks). The resulting engineered constructs were implanted ectopically in nude mouse. The presence of ceramic granules regulated tissue formation, both in vitro and in vivo. In particular, their dispersion in nanofat at a ratio of 1:16 led to significantly increased cell number and glycosaminoglycan accumulation in vitro, as well as amount and inter-donor reproducibility of bone formation in vivo. Our findings outline a strategy for efficient utilization of nanofat for bone regeneration in an autologous setting, which should now be tested at an orthotopic site.

15.
Am J Emerg Med ; 2019 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-31780188

RESUMO

BACKGROUND: Acute appendicitis (AA) is one of the most common diseases faced by the surgeon in the emergency department. In clinical practice, how to diagnose patients with AA accurately is still challenging. METHODS: We conducted a prospective study of 84 patients who presented in the emergency department with suspected AA and measured fecal calprotectin (FC) value. The final diagnosis of AA was independently determined without reference to the test results of FC. Then, we retrospectively analyzed the FC value for identifying AA. RESULTS: FC value in patients with AA were significantly higher than that in patients without AA (240.5 vs. 68.5 ug/g, P < 0.001). Receiver-operating characteristic analyses demonstrated FC value to be highly sensitive and specific for the diagnosis of AA, as indicated by an overall area under the curve (AUC) of 0.928 (500 times of boot strap estimated 95% CI, 0.855-0.972), with an optimal cut off point of 106 ug/g. FC levels in 26 patients with simple AA were significantly lower than it in the 14 patients with suppurative AA (206 vs. 304ug/g, P = 0.001). CONCLUSIONS: FC test provides a sensitive, convenient and economical method to help facilitate the diagnosis of AA in emergency department. Especially for hospitals without computed tomography equipment or patients who are not suitable to exposed to radiation, FC test is of great significance for improving the diagnostic accuracy of AA.

16.
Microbiologyopen ; : e955, 2019 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-31782623

RESUMO

Lake anchovy (Coilia ectenes taihuensis) is a sedentary, dominant fish species that forms an unmanaged fishery in Taihu Lake, eastern China. The environment and developmental stage of lake anchovy are likely important drivers of their gut microbiome, which is linked to host health and development. To investigate the relationship between the gut microbiome and three defined factors (fish sex, fish body size, and the local habitat), high-throughput sequencing of the 16S ribosomal RNA gene was used to study the microorganisms of 184 fish samples and four water samples collected in Taihu Lake. Four dominant bacterial phyla (Proteobacteria, Firmicutes, Planctomycetes, and Cyanobacteria) were present in all fish samples. We compared the microbial communities of males and females and found that the relative abundance of Corynebacteriaceae was significantly higher in males than in females, while the opposite trend was detected for Sphingomonadaceae. We also discovered that the relative abundance of Firmicutes was positively correlated with fish body size and that the proportions of Proteobacteria and Tenericutes were lower in larger fish than in fish of other sizes. Finally, we found that the difference in microbial richness between eastern and northern Taihu Lake was the most marked. Lake anchovy was rich in Lactobacillus and Clostridium in the eastern site, while those in the northern site had the highest abundance of Sphingomonas and Methylobacterium, suggesting that the local habitat may also influence the intestinal microbiome. These findings will not only help researchers understand the community composition of the intestinal microflora of lake anchovy but also contribute to the protection of fish resources in Lake Taihu and the sustainable use of lake anchovy.

17.
Biomolecules ; 9(11)2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31731492

RESUMO

Programmed cell death protein 1 (PD-1) is a biomarker on the surface of cells with a role in promoting self-tolerance by suppressing the inflammatory activity of T cells. In this work, one peptide of PD-1 was used as the template for molecular imprinting to form magnetic peptide-imprinted poly(ethylene-co-vinyl alcohol) composite nanoparticles (MPIP NPs). The nanoparticles were characterized by dynamic light scattering (DLS), high-performance liquid chromatography (HPLC), Brunauer-Emmett-Teller (BET) analysis, and superconducting quantum interference device (SQUID) analysis. Natural killer 92 (NK-92) cells were added to these composite nanoparticles and then incubated with human hepatoma (HepG2) cells. The viability and the apoptosis pathway of HepG2 were then studied using cell counting kit-8 (CCK8) and quantitative real-time polymerase chain reaction (qRT-PCR), respectively. These nanoparticles were found to significantly enhance the activity of natural killer cells toward HepG2 cells by increasing the expression of nuclear factor kappa B (NF-κB), caspase 8, and especially caspase 3.

18.
Phys Chem Chem Phys ; 21(45): 25118-25125, 2019 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-31691692

RESUMO

Y2O2S:Eu,Ti,Mg, a persistent luminescence (PersL) material that exhibits eye-sensitive red emission for longer than 4-5 h, has attracted much attention and has been intensively researched over the past decade. If it is figured out how to prolong its decay time for longer than 8 h, the amazing candle-like red PersL performance, once lit, can illuminate a room all night without electricity. However, the PersL mechanism is still confusing, since different investigators have their own unique understanding about it based on their personal experimental observations. In this work, a more comprehensive and detailed investigation of the PersL mechanism is carried out, based on the defect levels induced by Eu, Ti, and Mg impurities and anion vacancies, using first-principles calculations. Our calculated results suggest that the empty spin-down 4f levels of Eu3+ appear in the band gap, while the occupied spin-up 4f levels are just below the valence band maximum (VBM). The 3d levels of Ti4+ are located in the band gap, with the highest levels around 1.4 eV below the conduction band minimum (CBM). Positively charged anion vacancies were found to induce empty defect levels just below the CBM and so could serve as electron trap centers, which prolong the lifetimes of excited electrons and lead to the PersL of the Ti4+ ion. When Eu3+ is co-doped with Ti4+, the energy of the excited Ti4+ ions is transferred to Eu3+. This mechanism can explain well most of the experimental observations that have appeared in the literature over the past decade. The obtained PersL mechanism is very clear in terms of the roles played by most types of defect, so we hope it can provide physical understanding and create intrigue around the idea of practical guidelines for the design of new red PersL materials in the future.

19.
Ann Vasc Surg ; 2019 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-31743777

RESUMO

OBJECTIVE: This retrospective study aims to investigate the effects of the endovascular and surgical strategy for treating patients with Acute Mesenteric Venous Thrombosis (AMVT). METHODS: We retrospectively studied 68 patients with AMVT who underwent treatment in Jinling Hospital during the period from January 2009 to December 2014. The mean age was 45 ± 12 years (range 20 to 72 years). All patients were treated by using the combined treatment that included endovascular treatment, damage control surgery, surgical intensive care, and intestinal rehabilitation treatment. Clinical outcomes and complications were compared during the follow-up period. RESULTS: All the 68 cases received anticoagulant treatment. However, only 24 received the endovascular intervention, 19 received surgical resection, and 25 patients received endovascular treatment combined with bowel resection. The overall mortality rate was 2.94% (2 cases). Bowel resection range significantly decreased(92±14cm vs. 162±27cm, t=-2.377, P= 0.022)in the combination therapy group, when compared with the surgery group. During the 1-year follow-up period, 4 cases suffered from short bowel syndrome. CONCLUSIONS: Our study indicates that AMVT can be successfully treated with the early improvement of intestinal blood circulation. Further, our applied combined approach showed a favorable outcome in mesenteric thrombosis patients and reduced the mortality rate by improving the prognosis significantly.

20.
Sci Rep ; 9(1): 16294, 2019 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-31704945

RESUMO

Most of the recent successful object detection methods have been based on convolutional neural networks (CNNs). From previous studies, we learned that many feature reuse methods improve the network performance, but they increase the number of parameters. DenseNet uses thin layers that have fewer channels to alleviate the increase in parameters. This motivated us to find other methods for solving the increase in model size problems introduced by feature reuse methods. In this work, we employ different feature reuse methods on fire units and mobile units. We solved the problem and constructed two novel neural networks, fire-FRD-CNN and mobile-FRD-CNN. We conducted experiments with the proposed neural networks on KITTI and PASCAL VOC datasets.

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