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1.
Clin Plast Surg ; 50(1): 33-41, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36396259

RESUMO

Minimally invasive facial rejuvenation techniques are gaining attention because of their advantages such as less trauma, quick recovery, high safety, obvious results, and repeatable operation. In this article, the principle, the operation method, advantages, and disadvantages of the new fast recovery suspension technique modified by the authors are described in detail, and the clinical cases are listed to further illustrate the efficacy of the modified operation. The authors also compared this procedure with other common facial rejuvenation techniques. It is hoped that our article can provide a reference for clinicians to better use facial rejuvenation technology.


Assuntos
Face , Rejuvenescimento , Humanos , Face/cirurgia
2.
Sci Total Environ ; 855: 158922, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36155038

RESUMO

Microplastics have been proven to be one of the critical environmental pollution issues. Moreover, microfibers, the most prominent form of microplastics in the environment, have likewise attracted the attention of various countries. With the increase in global population and industrialization, the production and use of fibers continue to increase yearly. As a result, a large number of microfibers are formed. If fiber products are not used or handled correctly, it will cause direct/indirect severe microfiber environmental pollution. Microfibers will be further broken into smaller fiber fragments when they enter the natural environment. Presently, researchers have conducted extensive research in the identification of microfibers, laying the foundation for further resourcefulness research. This work used bibliometric analysis to review the microfiber contamination researches systematically. First, the primary sources of microfibers and the influencing factors are analyzed. We aim to summarize the influence of the clothing fiber preparation and care processes on microfiber formation. Then, this work elaborated on the migration in/between water, atmosphere, and terrestrial environments. We also discussed the effects of microfiber on ecosystems. Finally, microfibers' current and foreseeable effective treatment, disposal, and resource utilization methods were explained. This paper will provide a structured reference for future microfiber research.


Assuntos
Plásticos , Poluentes Químicos da Água , Microplásticos , Poluentes Químicos da Água/análise , Têxteis , Ecossistema
3.
Sci Total Environ ; 858(Pt 1): 159800, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36309261

RESUMO

Antibiotics are ubiquitous in wastewater and surface water and their presence is of grave concern. Chlorination, an important disinfection process used in wastewater treatment plants and waterworks, causes antibiotics to be degraded. However, interactions of antibiotics with chlorine result in the generation of multiple transformation products (TPs). TPs may be more toxic than the parent compounds, but their structures, yields and ecotoxicity remain to be ascertained in most cases. This study examined the degradation by chlorine of two typical macrolide (MLs) antibiotics, erythromycin (ERY) and roxithromycin (ROX), and identified the TPs formed as a result of ERY and ROX chlorination. The ecotoxicity of ERY, ROX and their TPs was evaluated using a combination of bioassay and ECOSAR prediction. The degradation of ERY and ROX followed pseudo-first-order kinetic at the molar ratio of FAC to MLs of 10:1, and the degradation kinetic rate depends on pH values. Six TPs of ERY including three chlorinated TPs, and six TPs of ROX including two chlorinated TPs were identified. The tertiary N of the desosamine moiety of ERY and ROX was determined to be the main reactive site. Demethylation and chlorine substitution at the reactive site are the main degradation pathways of ERY and ROX. ECOSAR results showed that the chlorinated byproducts of ERY TP578, TP542 and TP528, and the reduced hydroxylation products of ROX TP851 exhibited higher ecotoxicity than their parent compounds. However, algae growth inhibition assays indicated that the overall ecotoxicity of the chlorinated ERY or ROX mixture was lower than that of ERY or ROX prior to chlorination. This may be attributed to the removal of the parent compound and lower yields of toxic substances. While the yields of the toxic TPs may be low, their accumulation and combined effects of the TPs and other co-occurring pollutants should be examined further.


Assuntos
Roxitromicina , Poluentes Químicos da Água , Purificação da Água , Halogenação , Cloro , Cinética , Poluentes Químicos da Água/análise , Purificação da Água/métodos , Antibacterianos/toxicidade , Eritromicina
4.
Sci Total Environ ; 857(Pt 2): 159546, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36265641

RESUMO

Afforestation has been initiated in Northeast Asia to improve ecological status. The responses of the regional hydrological cycle to vegetation restoration remain insufficiently explored. This study uses a variety of satellite-derived vegetation variables and hydrological cycle components to scan the eco-hydrological regimes in the Three-North Region of China and Mongolia during the past four decades. We observe that vegetation productivity increases mainly in North China (NC), Northeast China (NEC), Northwest China (NWC), and the north of Inner Mongolia and Mongolia. Precipitation and runoff show a decreasing trend (-0.4 mm/year and - 0.6 mm/year, respectively), yet they are less correlated to the normalized difference vegetation index and leaf area index. Along with increasing vegetation productivity, evapotranspiration increases (0.05 mm/year) obviously in NC and NEC, while root soil moisture (-0.001 m3/m3/year) and terrestrial water storage (-2.0 mm/year) decrease in NC and parts of NEC and NWC. The correlation coefficient between evapotranspiration and vegetation variables is up to 0.73. Collectively, results imply one potential adverse response of terrestrial water fluxes to increasing vegetation. Independent ecological and hydrological datasets further corroborate our work. Climatic factors (i.e., downward shortwave radiation and air temperature) and human activities (i.e., aerosol optical depth, carbon dioxide, and water withdrawal) substantially affect regional hydrological cycles. Considering the increasing vegetation productivity in the Three-North Region of China and Mongolia is likely to continue in the 21st century based on the Sixth Coupled Model Intercomparison Project (CMIP6) simulations, the terrestrial water fluxes may undergo deficit pressure. Overall, this study comprehensively investigates the vegetation and hydrology interplays, and provides a reference for protecting and improving ecological-hydrological conditions in Northeast Asia.


Assuntos
Efeitos Antropogênicos , Hidrologia , Humanos , Mongólia , China , Água , Mudança Climática , Ecossistema
5.
Sci Total Environ ; 857(Pt 1): 159426, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36244483

RESUMO

Green innovation (GI) is an important way to build an ecological civilization and an innovative country. The study on urban green innovation (UGI) is of great significance for enriching the research on GI and rationally formulating high-quality urban development policies. The green patent data obtained using a web crawler was used to represent the level of UGI. The spatiotemporal evolution and influencing factors of UGI in China were analyzed by standard deviation ellipses, spatial autocorrelation, and Geodetector. The research shows that: From 2005 to 2020, the level of UGI in China tended to rise rapidly. The center of gravity of UGI in China was located in the southeast of China's geometric center and tended to move to the south and west. The standard deviation ellipse was distributed in a "northeast-southwest" pattern, the area was gradually shrinking, and the length of the two semi-axes was shortening. UGI in China showed obvious global and local spatial autocorrelations. The degree of global spatial autocorrelation was gradually increasing. Among the types of local spatial autocorrelation, the largest number of low-low agglomeration cities was mainly located in the northwest and southwest part of China, while high-high agglomeration cities were distributed in Beijing-Tianjin-Hebei, Yangtze River Delta, and Pearl River Delta. The government intervention expressed by the proportion of scientific and technological expenditure in fiscal expenditure and environmental regulation is the dominant factor affecting UGI.


Assuntos
Rios , Reforma Urbana , Cidades , China , Pequim , Desenvolvimento Econômico
6.
Front Cardiovasc Med ; 9: 973129, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36451919

RESUMO

Aim of the review: To assess the risk of hypovolemia for sodium-glucose cotransporter-2 (SGLT2) inhibitors treatment. Method: A systematic literature retrieval was performed in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and Scopus from inception up to 4 October 2022, Data for study characteristics and outcomes of interest were extracted from each eligible study. Risk ratios (RRs) with a 95% confidence interval (CI) for hypovolemia were calculated using a random-effect model. Results: A total of 57 studies (n = 68,622) were included in our meta-analysis, with a result of 1,972 hypovolemia incidents (1,142 in the SGLT2 inhibitors group and 830 in the control group). The pooled RR was 1.12 (95% CI: 1.02-1.22). It is evident that receiving SGLT2 inhibitors increased the risk of hypovolemia. When stratified by category of SGLT2 inhibitors the result was consistent; when the subgroup was analyzed by age, the pooled RR was 1.07 (95% CI: 0.94-1.23) in patients aged ≥65 years and 1.14 (95% CI: 1.02-1.28) in those aged <65 years. When comparing the baseline estimated glomerular filtration rate (eGFR) of less than or equal to 60 mL/min/1.73 m2 with a baseline eGFR greater than 60 mL/min/1.73 m2, the pooled RR was 1.21, (95% CI: 1.00-1.46) and 1.08, (95%CI: 0.98-1.20), respectively. Conclusion: Our meta-analysis has demonstrated that SGLT2 inhibitors increased the risk of hypovolemia in patients with Type 2 Diabetes Mellitus (T2DM). It is necessary to pay attention to the risk of hypovolemia associated with SGLT2 inhibitors, especially in older individuals and those with moderate renal impairment. Systematic review registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42020156254].

7.
Mitochondrial DNA B Resour ; 7(11): 2018-2020, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36451969

RESUMO

In this study, the complete mitochondrial genome of Niwaella nigrolinea (Cypriniformes: Cobitidae) from Zhejiang, China, was determined for the first time. We found that the sequenced length of the complete mitochondrial genome of N. nigrolinea was 16,565 bp. The genome contained 13 protein-coding genes, 22 transfer RNAs, two ribosomal RNAs, and two non-coding regions, identical to most other vertebrates. Our phylogenetic analysis results confirmed that N. nigrolinea was close to an unclassified Cobitis sp. and the fishes of the genus Cobitis. These data would contribute to the genetic conservation genetics and stock evaluation of N. nigrolinea.

8.
Mol Biotechnol ; 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36454533

RESUMO

The development of cholangiocarcinoma (CCA) can be regulated by extracellular vesicles (EVs). In this study, we intend to investigate whether tumor cell-derived EVs delivering microRNA (miR)-210 affect CCA development, involved with reversion-inducing-cysteine-rich protein with kazal motifs (RECK). In silico analysis was performed for identifying differentially expressed miRs and the downstream target genes. The CCA related microarray GSE77984 was used to verify the expression of the target genes in CCA tissue samples. Targeting relationship between miR-210 and RECK was assayed. EVs were extracted from CCA cells, followed by co-culture with CCA cells. The in vitro and in vivo roles of tumor cell-derived EVs on the growth and metastasis of CCA cells were assayed. Upregulated miR-210 and downregulated RECK were found in CCA. CCA cells could uptake tumor cell-derived EVs, and the EVs could promote their migration, invasion, and chemoresistance. RECK expression could be target and inhibited by miR-210. It was further confirmed in vivo that miR-210 shuttled by tumor cell-derived EVs could specifically inhibit RECK expression, which promotes growth, metastasis and chemoresistance of CCA cells. Our current study highlighted that tumor cell-derived EVs could deliver miR-210 to CCA cells, where miR-210 specifically decreases RECK expression, which facilitates growth, metastasis and chemoresistance in CCA.

9.
Front Genet ; 13: 997739, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36467998

RESUMO

A large number of colon adenocarcinoma (COAD) patients are already advanced when diagnosed. In this study, we aimed to further understand the mechanism of tumor development in early COAD by focusing on epithelial-mesenchymal transition (EMT) and long non-coding RNAs (lncRNAs). Expression profiles of early COAD patients were obtained from public databases. EMT-related lncRNAs were used as a basis for constructing molecular subtypes through unsupervised consensus clustering. Genomic features, pathways and tumor microenvironment (TME) were compared between two subtypes. LncATLAS database was applied to analyze the relation between lncRNAs and transcription factors (TFs). First order partial correlation analysis was conducted to identify key EMT-related lncRNAs.C1 and C2 subtypes with distinct prognosis were constructed. Oncogenic pathways such as EMT, KRAS signaling, JAK-STAT signaling, and TGF-ß signaling were significantly enriched in C2 subtype. Higher immune infiltration and expression of immune checkpoints were also observed in C2 subtype, suggesting the key EMT-related lncRNAs may play a critical role in the modulation of TME. In addition, JAK-STAT signaling pathway was obviously enriched in upregulated TFs in C2 subtype, which indicated a link between key lncRNAs and JAK-STAT signaling that may regulate TME. The study further expanded the research on the role of EMT-related lncRNAs in the early COAD. The six identified EMT-related lncRNAs could serve as biomarkers for early screening COAD.

10.
Zhongguo Zhong Yao Za Zhi ; 47(19): 5336-5343, 2022 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-36472041

RESUMO

The mechanism of Rehmanniae Radix Praeparata against osteoarthritis was investigated based on network pharmacology, molecular docking, and in vitro experiments in the present study. Osteoclast models were established via receptor activator of nuclear factor-κB ligand(RANKL) and macrophage colony-stimulating factor(M-CSF) inducing RAW264.7 cells. Further, the influence of Rehmanniae Radix Praeparata on the activity of tartrate-resistant acid phosphatase(TRAP) was evaluated and the efficacy of Rehmanniae Radix Praeparata in the treatment of osteoarthritis was verified. The active components of Rehmanniae Radix Praeparata were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) and literature, and the potential targets of the components were collected from SwissTargetPrediction. Osteoarthritis disease targets were searched in Online Mendelian Inheritance in Man(OMIM), Therapeutic Target Database(TTD), GeneCards, and DisGeNET. The intersection targets of Rehmanniae Radix Praeparata and osteoarthritis were obtained by Venny platform. The protein-protein interaction(PPI) network was constructed by Cytoscape 3.8.2, and key targets were obtained based on topology algorithm. The Database for Annotation, Visualization and Integrated Discovery(DAVID) was used to perform Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis. Finally, the mRNA expression of the key targets was determined by RT-qPCR and the binding activity between the components and key targets was validated by molecular docking. The results showed that Rehmanniae Radix Prae-parata inhibited the TRAP activity, thus inhibiting bone resorption by osteoclasts and treating osteoarthritis. By network pharmacology, 14 active components of Rehmanniae Radix Praeparata and 126 intersection targets were obtained. The network pharmacology enrichment results revealed 432 biological processes and 139 signaling pathways. Key targets such as proto-oncogene tyrosine-protein kinase Src(SRC), signal transducer and activator of transcription 3(STAT3) and transcription factor p65(RELA) were obtained according to the degree in topological analysis. SRC was highly expressed in osteoclasts, which accelerated the development of osteoarthritis. Therefore, SRC was selected for subsequent verification, and Rehmanniae Radix Praeparata decreased the gene expression level of SRC. The molecular docking showed that acteoside, isoacteoside, raffinose had good bonding activity with SRC, suggesting that they might be the critical components in treating osteoarthritis. In conclusion, Rehmanniae Radix Praeparata can inhibit bone resorption by osteoclasts and balance the metabolism of articular cartilage and subchondral bone via acting on SRC, thus playing a therapeutic role in osteoarthritis. In addition, Rehmanniae Radix Praeparata may exert overall efficacy on osteoarthritis through other targets such as STAT3 and RELA, and other related pathways such as PI3 K-AKT and IL-17 signaling pathways.

11.
Asia Pac J Public Health ; : 10105395221134651, 2022 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-36321513

RESUMO

China is a multi-ethnic country, and the prevalence of Helicobacter pylori (H pylori) infection may be diverse among ethnics. This meta-analysis was conducted to compare the prevalence of H pylori infection between Tibetans and Han ethnics. Ten studies that reported the prevalence of H pylori infection between Tibetans and Hans in China were eligible. The pooled prevalence of H pylori infection was 62.2% versus 55.3% among Tibetans and Hans, respectively. Tibetans had a higher risk of H pylori infection than Hans (odds ratio [OR] = 1.38, 95% confidence interval [CI] [1.05, 1.80]). In subgroup analysis, Tibetans with upper gastrointestinal symptoms (OR = 1.51, 95% CI [1.06-2.16]), inhabiting in Tibet (OR = 1.51, 95% CI [1.22, 1.87]), or inhabiting in Northwestern region (OR = 1.15, 95% CI [1.00, 1.31]) had significantly higher risks of H pylori infection. In addition, in the recent 10 years, Hans showed a decreased risk of H pylori infection (OR = 1.81, 95% CI [1.42, 2.30]). Heterogeneity was common, while sensitivity analyses showed partially inconsistent results against main findings. This study demonstrated higher prevalence of H pylori infection in Tibetans compared with Hans, especially in recent years, or in Tibet and northwest China, as well as symptomatic Tibetans. The results suggest tailored strategy and robustness need to be further considered for H pylori screening and eradication among Tibetans.

12.
Int J Lab Hematol ; 2022 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-36358022

RESUMO

INTRODUCTION: AML patients with KMT2A-MLLT3 and other 11q23 abnormalities belong to the intermediate and high-risk level groups, respectively. Whether the poor prognostic value of Ecotropic Viral Integration site-1 (EVI1) overexpression suits either the subtypes of KMT2A-MLLT3 or Non-KMT2A-MLLT3 AML patients (intermediate and high risk group) needs to be further investigated. METHODS: We retrospectively analyzed the clinical characteristics of 166 KMT2A-r and KMT2A-PTD AML patients. RESULTS: For the Non-KMT2A-MLLT3 group, patients in the EVI1-high subgroup had shorter OS and DFS and higher CIR than those in the EVI1-low subgroup (p = .027, p = .018, and p = .020, respectively). Additionally, both KMT2A-MLLT3 and Non-KMT2A-MLLT3 patients who received chemotherapy alone had poorer prognosis than patients who also received allogeneic hematopoietic stem cell transplant (allo-HSCT) regardless of their EVI1 expression level (all p < .001). For transplanted patients with KMT2A-MLLT3 or Non-KMT2A-MLLT3 rearrangement, the EVI1-high subgroup had worse prognosis than the EVI1-low subgroup (all p < .05). The 2-year CIR of the KMT2A-MLLT3 and Non-KMT2A-MLLT3 groups with high EVI1 expression was high (52% and 49.6%, respectively). However, for patients with low EVI1 expression, the 2-year CIR of transplanted patients with KMT2A-MLLT3 and Non-KMT2A-MLLT3 was relatively low. CONCLUSIONS: Our study showed that for the Non-KMT2A-MLLT3 group, the EVI1-high group had shorter OS and DFS than the EVI1-low group. High EVI1 expression showed an adverse effect in AML with KMT2A rearrangement in different risk stratification subtypes. For the EVI1-high patients with non-KMT2A-MLLT3 rearrangement, other novel regimens towards relapse should be taken into consideration.

14.
Sci Data ; 9(1): 684, 2022 11 10.
Artigo em Inglês | MEDLINE | ID: mdl-36357411

RESUMO

Cities in China are on the frontline of low-carbon transition which requires monitoring city-level emissions with low-latency to support timely climate actions. Most existing CO2 emission inventories lag reality by more than one year and only provide annual totals. To improve the timeliness and temporal resolution of city-level emission inventories, we present Carbon Monitor Cities-China (CMCC), a near-real-time dataset of daily CO2 emissions from fossil fuel and cement production for 48 major high-emission cities in China. This dataset provides territory-based emission estimates from 2020-01-01 to 2021-12-31 for five sectors: power generation, residential (buildings and services), industry, ground transportation, and aviation. CMCC is developed based on an innovative framework that integrates bottom-up inventory construction and daily emission estimates from sectoral activities and models. Annual emissions show reasonable agreement with other datasets, and uncertainty ranges are estimated for each city and sector. CMCC provides valuable daily emission estimates that enable low-latency mitigation monitoring for cities in China.


Assuntos
Dióxido de Carbono , Combustíveis Fósseis , Carbono/análise , Dióxido de Carbono/análise , China , Cidades , Mudança Climática
15.
Neuron ; 2022 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-36370710

RESUMO

The coordination mechanism of neural innate immune responses for axon regeneration is not well understood. Here, we showed that neuronal deletion of protein tyrosine phosphatase non-receptor type 2 sustains the IFNγ-STAT1 activity in retinal ganglion cells (RGCs) to promote axon regeneration after injury, independent of mTOR or STAT3. DNA-damage-induced cGAMP synthase (cGAS)-stimulator of interferon genes (STINGs) activation is the functional downstream signaling. Directly activating neuronal STING by cGAMP promotes axon regeneration. In contrast to the central axons, IFNγ is locally translated in the injured peripheral axons and upregulates cGAS expression in Schwann cells and infiltrating blood cells to produce cGAMP, which promotes spontaneous axon regeneration as an immunotransmitter. Our study demonstrates that injured peripheral nervous system (PNS) axons can direct the environmental innate immune response for self-repair and that the neural antiviral mechanism can be harnessed to promote axon regeneration in the central nervous system (CNS).

16.
World J Gastrointest Oncol ; 14(11): 2288-2294, 2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-36438696

RESUMO

BACKGROUND: Inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) is rare with a low malignant potential. Hepatic IPT-like FDCS has similar clinical features to hepatocellular carcinoma (HCC), making it extremely difficult to distinguish between them in clinical practice. We describe the case of a young female patient diagnosed with HCC before surgery, which was pathologically diagnosed as IPT-like FDCS after the left half of the liver was resected. During 6 mo of follow-up, the patient recovered well with no signs of recurrence or metastasis. CASE SUMMARY: A 23-year-old female patient with a 2-year history of hepatitis B presented to the Affiliated Hospital of Guizhou Medical University. She was asymptomatic at presentation, and the findings from routine laboratory examinations were normal except for slightly elevated alpha-fetoprotein levels. However, ultrasonography revealed a 3-cm diameter mass in the left hepatic lobe, and abdominal contrast-enhanced computed tomography revealed that the tumor had asymmetrical enhancement during the arterial phase, which declined during the portal venous phase, and had a pseudo-capsule appearance. Based on the findings from clinical assessments and imaging, the patient was diagnosed with HCC, for which she was hospitalized and had undergone laparoscopic left hepatectomy. However, the tumor specimens submitted for pathological analyses revealed IPT-like FDCS. After surgical removal of the tumor, the patient recovered. In addition, the patient continued to recover well during 6 mo of follow-up. CONCLUSION: Hepatic IPT-like FDCS is difficult to distinguish from HCC. Hepatectomy may provide beneficial outcomes in non-metastatic hepatic IPT-like FDCS.

17.
Front Vet Sci ; 9: 1006676, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36439336

RESUMO

In this study, to optimize the Staphylococcus aureus control program, a meta-analysis was conducted to investigate the epidemiology and antimicrobial resistance (AMR) profile of S. aureus-associated bovine mastitis in China from 2000 to 2020. A total of 33 publications from PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI) database were included in our research, among which nine publications included the AMR test. The pooled prevalence of S. aureus was 36.23%, and subgroup analysis revealed that the prevalence dropped from 2000-2010 to 2011-2020, which shows that China is on the right track. The pooled AMR rate indicate isolates were most resistant to ß-lactams (50.68%), followed by quinolones (36.23%), macrolides (34.08%), sulfonamides (32.25%), tetracyclines (27.83%), aminoglycosides (26.44%), lincosamides (23.39%), and amphenicol (10.33%). Both the pooled prevalence and AMR of S. aureus in China are higher than those in Western countries, such as Germany, Belgium, Ireland, and the United States-countries with a long animal husbandry history and good management. Thus, there is still room to improve the treatment of S. aureus-associated bovine mastitis in China.

18.
Curr Neurovasc Res ; 2022 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-36437722

RESUMO

Background- A certain number of patients with single subcortical small infarction (SSSI) in the lenticulostriate artery (LSA) territory present with early neurological deterioration (END). Objective-We sought to identify more specific predicting imaging marker for END in lenticulostriate SSSI patients. Methods-We screened patients in a prospective hospital-based registry of stroke in the first Affiliated Hospital of Zhengzhou University from January 2015 to December 2020. Lesion locations were defined as posterior type when more than half of the lesion was located in the posterior part of the corona radiata divided by the midline, which was drawn between the tangents of the anterior and posterior horns of the lateral ventricle and was adjacent to the lateral ventricle at the same time. END was defined as an increase of ≥2 points in total National Institutes of Health Stroke Scale score or ≥1 point. A multivariate logistic analysis was used to assess the imaging predictors for END. Results-418 patients were enrolled in the final data analysis. Among them, 206 (49. 3%) cases were rated as the posterior type and71(17. 0%)cases had END. A multivariate logistic analysis showed that only posterior type (adjusted odds ratio, 2. 126; 95% confidence interval, 1. 250-3. 614; P = 0. 005) was independently associated with the risk of END. Conclusions-The posterior type of lesion location represented an imaging marker predicting END in the lenticulostriate SSSI patients.

19.
BMC Pulm Med ; 22(1): 425, 2022 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-36401235

RESUMO

PURPOSE: This national study aimed to investigate the lung ultrasound (LUS) training and practice of respiratory therapists (RTs) in mainland China. METHODS: A cross-sectional multicenter survey was conducted from May 22, 2021 to August 12, 2021, through online platforms. This survey included RTs in mainland China. The survey was divided into four sections: (1) demographic characteristics and basic information; (2) basic information about LUS training and practice; (3) LUS practice details; and (4) Other ultrasound training and practice. RESULTS: A total of 514 responses were received, and 494 valid responses were included in the analysis. 81.2% (401/494) participants' highest degree of education was a bachelor's degree, and 43.1% (213/494) participants were at level II in terms of job ranking. 99.2%(490/494) participants agreed that the RTs needed to learn lung ultrasound, but only 12.3% (61/494) participants had received a LUS training course. Further, 66.2% (327/494) experienced participants responded to Sect. 3. Most of RTs used LUS when the patient had hypoxia (265/327, 81%) or dyspnea (260/317, 79.5%); they also used it during spontaneous breathing trial(SBT) (191/327, 58.4%) or in prone position (177/327, 54.1%). The A-line (302/327, 92.4%), B-line (299/327, 91.4%), lung slide (263/327, 80.4%), and bat sign (259/327, 79.2%) were well known as LUS signs. Also, 30.6% (100/327) participants did not use the LUS protocol in their clinical practice, and only 25.4%(83/327) participants said they had used LUS scores. Moreover, 55.7% (182/327) participants frequently changed the respiratory therapy strategy according to LUS results. CONCLUSIONS: We should improve the number and workplace of RTs in mainland China in the future. We should also standardize the application of LUS practice and training for RTs in mainland China and establish corresponding certification pathways.


Assuntos
Pneumopatias , Pulmão , Humanos , Estudos Transversais , Ultrassonografia/métodos , Pulmão/diagnóstico por imagem , Terapia Respiratória
20.
BMC Surg ; 22(1): 394, 2022 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-36401260

RESUMO

BACKGROUND: This study aimed to assess the clinical efficacy of one-stage posterior surgery combined with anti-Brucella therapy in the treatment of lumbosacral brucellosis spondylitis (LBS). METHODS: From June 2010 to June 2020, the clinical and radiographic data of patients with LBS treated by one-stage posterior surgery combined with anti-Brucella therapy were retrospectively analyzed. The visual analogue scale (VAS), Japanese Orthopaedic Association (JOA) and Oswestry Disability Index scores (ODI) were used to evaluate the clinical outcomes. Frankel's classification system was employed to access the initial and final neurologic function. Fusion of the bone grafting was classified by Bridwell's grading system. RESULTS: A total of 55 patients were included in this study with a mean postoperative follow-up time of 2.6 ± 0.8 years (range, 2 to 5). There were 40 males and 15 females with a mean age of 39.8 ± 14.7 years (range, 27 to 57). The Brucella agglutination test was ≥ 1:160 in all patients, but the blood culture was positive in 43 patients (78.1%). A statistical difference was observed in ESR, CRP, VAS, ODI, and JOA between preoperative and final follow-up (P < 0.05). Neurological function was significantly improved in 20 patients with preoperative neurological dysfunction after surgery. According to Bridwell's grading system, the fusion of bone grafting in 48 cases (87.2%) was defined as grade I, and grade II in 7 cases (12.7%). None of the infestation recurrences was observed. CONCLUSION: One-stage posterior surgery combined with anti-Brucella therapy was a practical method in the treatment of LBS with severe neurological compression and spinal sagittal imbalance.


Assuntos
Brucella , Brucelose , Fusão Vertebral , Espondilite , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Estudos Retrospectivos , Fusão Vertebral/métodos , Vértebras Lombares/cirurgia , Desbridamento/métodos , Espondilite/cirurgia , Brucelose/complicações , Brucelose/tratamento farmacológico , Brucelose/cirurgia
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