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1.
Front Biosci (Landmark Ed) ; 25: 593-605, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31585906

RESUMO

Fibrosis, or the excess deposition of fibrous tissue, is a critical feature of chronic kidney disease. Here, using renal fibrotic rat as a model, which was established via 5/6 nephrectomy (Nx), the role of TMEM45A transmembrane protein in renal fibrosis was investigated. The results indicated that 5/6 Nx gradually led to histopathological abnormalities and loss of kidney function in rats, which correlated with upregulation of TMEM45A and Notch1. Interestingly, in NRK-49F renal cells, overexpression of TMEM45A resulted in up-regulation of extracellular matrix (ECM) components as well as induction of Notch-1 and Jagged-1. These effects were weakened by DAPT, an inhibitor of the Notch pathway, suggesting an important role of Notch signaling in mediating the functions of TMEM45A in NRK-49F cells Moreover, TMEM45A knockdown by TMEM45A siRNA in NRK-49F cells diminished TGF-b1-induced upregulation of ECM components, inflammatory cytokines, Notch-1 and Jagged-1. Correspondingly, TGF-beta 1 exhibited pro-fibrogenic like effect in NRK-49F cells and induced TMEM45A and Jagged1/Notch expression. Collectively, these results demonstrate that TMEM45A plays an important role in renal fibrosis by regulating ECM components and Jagged1/Notch pathway.

2.
Mol Plant ; 2019 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-31669581

RESUMO

Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal target for elucidating novel UV-B responsive mechanisms. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites of the different phenylpropanoid branches in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were located in the barley-qingke differentiation regions and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified a number of determinants controlling natural variation of phenylpropanoid contents, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in this species.

3.
Sci Total Environ ; 701: 134466, 2019 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-31704412

RESUMO

Heavy metals (HMs) in soil cause adverse effects on ecosystem and human health. Quantifying ecological risk and human health risk (HHR) from sources can determine priority sources and help to mitigate the risks. In this research, geostatistics and positive matrix factorization (PMF) were used to identify and quantify the sources of soil HMs; and then ecological risk and HHR from different sources under woodland, construction land and farmland were quantitatively calculated by combining the potential ecological risk index (RI) and HHR assessment models with PMF model. Taking Jiedong District as an example, four sources were quantitatively apportioned, which were agricultural practices (23.08%), industrial activities (29.10%), natural source (22.87%) and traffic emissions (24.95%). For ecological risk, industrial activities were the greatest contributor, accounting for about 49.71%, 48.11% and 47.15% under construction land, woodland and farmland, respectively. For non-carcinogenic risk, agricultural practices were the largest source under woodland and farmland, while industrial activities were the largest source under construction land. As for carcinogenic risk, no matter which kind of land use, agricultural practices were the largest source. In addition, the health risks of children, including non-carcinogenic and carcinogenic risks, were higher than those of adults, and the trends in health risks for children and adults were similar. The integrated approach was useful to evaluate ecological risk and HHR quantification from sources under different land use, thereby providing valuable suggestions for reducing pollution and protecting human health from the sources.

4.
Cells ; 8(11)2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31726766

RESUMO

Nutrient recycling and mobilization from organ to organ all along the plant lifespan is essential for plant survival under changing environments. Nutrient remobilization to the seeds is also essential for good seed production. In this review, we summarize the recent advances made to understand how plants manage nutrient remobilization from senescing organs to sink tissues and what is the contribution of autophagy in this process. Plant engineering manipulating autophagy for better yield and plant tolerance to stresses will be presented.

5.
Top Magn Reson Imaging ; 28(5): 285-297, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31592995

RESUMO

The Human Placenta Project has focused attention on the need for noninvasive magnetic resonance imaging (MRI)-based techniques to diagnose and monitor placental function throughout pregnancy. The hope is that the management of placenta-related pathologies would be improved if physicians had more direct, real-time measures of placental health to guide clinical decision making. As oxygen alters signal intensity on MRI and oxygen transport is a key function of the placenta, many of the MRI methods under development are focused on quantifying oxygen transport or oxygen content of the placenta. For example, measurements from blood oxygen level-dependent imaging of the placenta during maternal hyperoxia correspond to outcomes in twin pregnancies, suggesting that some aspects of placental oxygen transport can be monitored by MRI. Additional methods are being developed to accurately quantify baseline placental oxygenation by MRI relaxometry. However, direct validation of placental MRI methods is challenging and therefore animal studies and ex vivo studies of human placentas are needed. Here we provide an overview of the current state of the art of oxygen transport and quantification with MRI. We suggest that as these techniques are being developed, increased focus be placed on ensuring they are robust and reliable across individuals and standardized to enable predictive diagnostic models to be generated from the data. The field is still several years away from establishing the clinical benefit of monitoring placental function in real time with MRI, but the promise of individual personalized diagnosis and monitoring of placental disease in real time continues to motivate this effort.

6.
J Nutr ; 2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31618431

RESUMO

BACKGROUND: Ectopic fat accumulation in skeletal muscle results in dysfunction and atrophy, but the underlying molecular mechanisms remain unclear. OBJECTIVE: The aim of this study was to investigate the effects of a high-fat diet (HFD) in modulating the structure and energy metabolism of skeletal muscle and the underlying mechanisms in mice. METHODS: Four-week-old male C57BL/6 J mice (n = 30) were allowed 1 wk for acclimatization. After 6 mice with low body weight were removed from the study, the remaining 24 mice were fed with a normal-fat diet (NFD; 10% energy from fat, n = 12) or an HFD (60% energy from fat, n = 12) for 24 wk. At the end of the experiment, serum glucose and lipid concentrations were measured, and skeletal muscle was collected for atrophy analysis, inflammation measurements, and phosphoproteomic analysis. RESULTS: Compared with the NFD, the HFD increased (P < 0.05) body weight (35.8%), serum glucose (64.5%), and lipid (27.3%) concentrations, along with elevated (P < 0.05) expressions of the atrophy-related proteins muscle ring finger 1 (MURF1; 27.6%) and muscle atrophy F-box (MAFBX; 44.5%) in skeletal muscle. Phosphoproteomic analysis illustrated 64 proteins with differential degrees of phosphorylation between the HFD and NFD groups. These proteins were mainly involved in modulating cytoskeleton [adenylyl cyclase-associated protein 2 (CAP2) and actin-α skeletal muscle (ACTA1)], inflammation [NF-κB-activating protein (NKAP) and serine/threonine-protein kinase RIO3 (RIOK3)], glucose metabolism [Cdc42-interacting protein 4 (TRIP10); protein kinase C, and casein kinase II substrate protein 3 (PACSIN3)], and protein degradation [heat shock protein 90 kDa (HSP90AA1)]. The HFD-induced inhibitions of the insulin signaling pathway and activations of inflammation in skeletal muscle were verified by Western blot analysis. CONCLUSIONS: Quantitative phosphoproteomic analysis in C57BL/6 J mice fed an NFD or HFD for 24 wk revealed that the phosphorylation of inflammatory proteins and proteins associated with glucose metabolism at specific serine residues may play critical roles in the regulation of skeletal muscle atrophy induced by an HFD. This work provides information regarding underlying molecular mechanisms for inflammation-induced dysfunction and atrophy in skeletal muscle.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31621035

RESUMO

Diastolic dysfunction is common in various cardiovascular diseases, which could be affected by adiponectin (APN). Nevertheless, the effects of APN on diastolic dysfunction in pressure overload model induced by transverse aorta constriction (TAC) remain to be further elucidated. Here, we demonstrated that treatment of APN attenuated diastolic dysfunction and cardiac hypertrophy in TAC mice. Notably, APN also improved active relaxation of adult cardiomyocytes, increased N2BA/N2B ratios of titin isoform, and reduced collagen type I to type III ratio and lysyl oxidase (Lox) expressions in the myocardial tissue. Moreover, APN supplementation suppressed TAC-induced oxidative stress. In vitro, inhibition of AMPK by compound C (Cpc) abrogated the effect of APN on modulation of titin isoform shift and the anti-hypertrophic effect of APN on cardiomyocytes induced by AngII. In summary, our findings indicate that APN could attenuate diastolic dysfunction in TAC mice, which are at least partially mediated by AMPK pathway.

8.
Arterioscler Thromb Vasc Biol ; : ATVBAHA119312589, 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31597442

RESUMO

OBJECTIVE: A high level of LDL-C (low-density lipoprotein cholesterol) is a major risk factor for cardiovascular disease. The E3 ubiquitin ligase named IDOL (inducible degrader of the LDLR [LDL receptor]; also known as MYLIP [myosin regulatory light chain interacting protein]) mediates degradation of LDLR through ubiquitinating its C-terminal tail. But the expression profile of IDOL differs greatly in the livers of mice and humans. Whether IDOL is able to regulate LDL-C levels in humans remains to be determined. Approach and Results: By using whole-exome sequencing, we identified a nonsynonymous variant rs149696224 in the IDOL gene that causes a G51S (Gly-to-Ser substitution at the amino acid site 51) from a Chinese Uygur family. Large cohort analysis revealed IDOL G51S carriers (+/G51S) displayed significantly higher LDL-C levels. Mechanistically, the G51S mutation stabilized IDOL protein by inhibiting its dimerization, preventing self-ubiquitination, and subsequent proteasomal degradation. IDOL(G51S) exhibited a stronger ability to promote ubiquitination and degradation of LDLR. Adeno-associated virus-mediated expression of IDOL(G51S) in mouse liver decreased hepatic LDLR and increased serum levels of LDL-C, total cholesterol, and triglyceride. CONCLUSIONS: Our study demonstrates that IDOL(G51S) is a gain-of-function variant responsible for high LDL-C in both humans and mice. These results suggest that IDOL is a key player regulating cholesterol level in humans.

9.
Artigo em Inglês | MEDLINE | ID: mdl-31603986

RESUMO

BACKGROUND: Evidence of the trend of the incidence of activities of daily living (ADL) disability among Chinese older people is limited. We aimed to investigate the time trends and potential risk factors for the incidence of ADL disability among Chinese elderly (65+ years). METHODS: We established two consecutive and non-overlapping cohorts (6,857 participants in the 2002 cohort and 5,589 participants in the 2008 cohort) from the Chinese Longitudinal Healthy Longevity Survey. ADL disability was defined as the need for assistance with at least one essential activity (dressing, bathing, toileting, eating, indoor activities, and continence). Cox proportional hazards models were used to identify factors associated with the trend in the incidence of ADL disability from 2002 to 2014. RESULTS: The incidence (per 1,000 person-years) of ADL disability decreased significantly from 64.2 in the 2002 cohort to 46.6 in the 2008 cohort (P <0.001), and decreasing trends in the incidence of ADL disability were observed for all sex, age and residence subgroups (all P < 0.001), even after adjusting for multiple potential confounding factors. Moreover, we found that adjustment for sociodemographic, lifestyle information, and cardiovascular risk factors (hypertension, diabetes, heart disease and stroke) explained less of the decline in ADL disability during the period from 2002 to 2014. CONCLUSION: The incidence of ADL disability among the elderly in China appears to have decreased during the study period, and this finding cannot be explained by existing sociodemographic and lifestyle information and cardiovascular risk factors.

10.
Environ Res ; 179(Pt A): 108801, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31606617

RESUMO

Although cost-effective, phytoremediation is too expensive when considering the large-scale pollution. Relative to harvesting the whole plant, it is more practicable to remove and dispose of senescent and dead leaves after phytoremediation. The phytoremediation efficiency of Festuca arundinacea for Cd was evaluated in this study, because over about 7% of the land area in China was contaminated with Cd. The accumulation, redistribution, and extraction of Cd were evaluated in different leaves of F. arundinacea intercropped with N-fixing species at different densities (Cicer arietinum L). The results showed that coordinate and malposed intercropping systems increased the dry weight of the senescent and dead leaves of F. arundinacea by 30-41% and 103-168% compared to the monoculture system, respectively. More Cd was redistributed to the senescent and dead leaves of F. arundinacea under both intercropping systems. Occupying only 22-30% of the total leaf biomass, senescent and dead leaves accumulated 74-88% of leaf Cd under different cultivation conditions. Relative to the monoculture system, intercropping decreased the amount of time needed to reduce soil Cd by 44-53%. The biomass production and Cd accumulation of F. arundinacea were higher in the malposed intercropping system, and it had higher remediation efficiency than the coordinate intercropping system. This study demonstrated that intercropping, especially malposed intercropping of F. arundinacea and C. arietinum L., is a practicable technology for leaf harvesting phytoremediation.

11.
iScience ; 21: 1-18, 2019 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-31654850

RESUMO

Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and different from other RASA family members (RASA1-RASA4), indicating its special functions in tumorigenesis. RASA5 mutations are rare, unlike other RASA members, whereas its promoter CpG methylation is frequent in multiple cancer cell lines and primary carcinomas and associated with patient's poor survival. RASA5 expression inhibited tumor cell migration/invasion and growth in mouse model, functioning as a tumor suppressor. RASA5 suppressed RAS signaling, depending on its Ras GTPase-activating protein catalytic activity, which could be counteracted by oncogenic HRas Q61L mutant. RASA5 knockdown enhanced Ras signaling to promote tumor cell growth. RASA5 also inhibited epithelial-mesenchymal transition (EMT) through regulating actin reorganization. Thus, epigenetic inactivation of RASA5 contributing to hyperactive RAS signaling is involved in Ras-driven human oncogenesis.

12.
Chemosphere ; 226: 891-897, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31509918

RESUMO

Eucalyptus globulus pre-treated by static magnetic fields of 30, 60, 120, 150 and 400 mT (mT) before sowing were used in a 45-day experiment to remediate soil containing Cd, Hg, Pb, Zn, Cr and Cu. The influence of magnetic fields on its remediation efficiency was evaluated. Magnetic fields with strength of 30, 60, 120 and 150 mT increased the biomass yield of the species by 3.1, 19.4, 48.1 and 60.9%, respectively, while 400 mT decreased the yield by 16.7%. Comparing with the control exposed only to the earth's geomagnetic field, all plants pre-treated by static magnetic field had significantly higher metal concentrations with the highest values achieved in the field of 400 mT. Higher transpiration rate of the plants along with exposure to static magnetic fields induced lower soil moisture content and was beneficial to environmental control because it could reduce the leachate during the phytoremediation process. Among all static magnetic field treatments, 150 mT was the best to improve the phytoremediation and alleviate the environmental risk, which shortened the time to purify Cd, Pb and Cu by 27.8-73.2%, 27.3-74.7% and 2.5-50.6%, respectively and intercepted 31.6-86.1% of the leachate. Therefore, static magnetic field with appropriate intensity is a suitable candidate to improve phytoremediation efficiency through enhancing the biomass production, toxin uptake and leachate interception.

13.
J Exp Clin Cancer Res ; 38(1): 406, 2019 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-31519186

RESUMO

Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a strict regulation mechanism of iron metabolism due to its potential toxicity. As a cancer of the bone marrow and blood cells, leukemia threatens human health seriously. Current studies suggest that dysregulation of iron metabolism and subsequent accumulation of excess iron are closely associated with the occurrence and progress of leukemia. Specifically, excess iron promotes the development of leukemia due to the pro-oxidative nature of iron and its damaging effects on DNA. On the other hand, leukemia cells acquire large amounts of iron to maintain rapid growth and proliferation. Therefore, targeting iron metabolism may provide new insights for approaches to the treatment of leukemia. This review summarizes physiologic iron metabolism, alternations of iron metabolism in leukemia and therapeutic opportunities of targeting the altered iron metabolism in leukemia, with a focus on acute leukemia.

14.
Theranostics ; 9(21): 6334-6353, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31534554

RESUMO

Rationale: Activating transcription factor 4 (ATF4) is a central regulator of the cellular stress response and reduces tumor burden by controlling the expression of target genes implicated in the induction of apoptosis. Evidence shows ATF4 activation is responsible for proteasome inhibitor bortezomib (BTZ)-induced osteosarcoma (OS) cell death. However, it remains unclear how such suppressive function is impaired during prolonged therapeutic interventions. Methods: Stable cells and in vivo xenograft models were generated to reveal the essential role of ATF4 in cell apoptosis and tumor growth. Fluorescence in situ hybridization (FISH) and immunohistochemistry were employed to detect the expression and significance of ATF4 in the specimens from osteosarcoma patients. Biochemical differences between chemoresistant and chemosensitive cancer cells were determined by proliferation, apoptosis, real-time PCR, immunoblotting and immunofluorescence. Promoter activity was analysed using the luciferase reporter assay. Immunoprecipitation was used to explore the interaction of proteins with other proteins or DNAs. Results: ATF4 significantly inhibited OS tumorigenesis, whereas knockdown of ATF4 prevented the antitumor effects of BTZ. Normal osteoblasts are supposed to preferentially express ATF4, but ATF4 silencing was detected in both OS clinical samples and BTZ-resistant sublines (OS/BTZ). We found that ATF4 downregulation was tightly linked to the aberrant expression of RET, primarily due to RET stabilization in OS/BTZ cells. Loss of RET upregulated ATF4 and potentiated the apoptotic response to BTZ. ATF4 recognized the TK domain of RET by recruiting its transactivated E3 ligase Cbl-c to accelerate RET proteasomal turnover, which in turn prevented BTZ resistance. In contrast, the chaperone GRP78 bound to RET and interfered with ATF4/RET interactions, promoted RET stabilization. Intriguingly, ATF4 repressed GRP78 transcription in OS/BTZ cells via the first ERSE, instead of transactivating GRP78 in wild-type OS via classical CRE element, revealing a dual targeting of RET and GRP78 to overcome chemoresistance. Conclusion: The results uncover a crucial role for ATF4 in blocking the progression and resistance response in RET/GRP78-positive human osteosarcoma.

15.
Environ Monit Assess ; 191(10): 629, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31511991

RESUMO

Mangrove forests are widely located along coastlines. They have been identified to be inimitable and dynamic ecosystems. This study investigated the trace metals in mangrove water and surface sediments of Nansha, Guangzhou, China. Zn (148.42 ± 247.47 µg L-1) was the most abundant metal in waters, followed by As (82.34 ± 118.95 µg L-1), Pb (22.96 ± 120.50 µg L-1), and Ni (19.42 ± 47.84 µg L-1). In sediments, the most abundant metal was Fe (27.04 ± 1.91 g kg-1), followed by Mn (1049.04 ± 364.11 mg kg-1), Zn (566.33 ± 244.37 mg kg-1), and Cr (106.9 ± 28.51 mg kg-1). Higher contents of trace metals were detected in vicinity areas of the river mouth. The results of pollution indexes, including contamination factor, enrichment factor, and geo-accumulation index, indicated the pollution of Cd, Cu, Pb, and Zn in sediments. The Spearman correlation and cluster analysis were used to evaluate the metal sources. In water, the significant correlations among Zn and water chemical parameters (Na, Mg, K, Ca, conductivity, pH, and Cl) might indicate the natural source of Zn from the seawater. Water sampling sites in estuaries and coastal areas were clustered separately, which might indicate the influences of upstream water and the seawater, respectively. In sediments, the significant relationships among Cd, Pb, and Zn concentrations were likely to imply the emissions from industries and exploitation of the Pb-Zn mine. The occurrence of Cr and Cu in sediments can be attributed to the spills of lubricants or oil. Cd in sediments could cause serious ecological risk.

16.
Opt Express ; 27(14): 19463-19473, 2019 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-31503705

RESUMO

Extremely anisotropic media such as anisotropic zero-index media allow wave propagation in extraordinary ways that are absent in isotropic systems. Here, we propose an approach to realize a type of extremely anisotropic effective epsilon-near-zero media by exploiting anisotropic waveguide metamaterials. The metamaterial is composed of two kinds of dielectrics with metal wires in waveguides. Extreme anisotropy is realized by alternating layers of the two kinds of dielectrics, which lead to different cut-off frequencies for transverse electric modes in different directions. Anisotropic effective epsilon-near-zero media with low loss can be obtained around the cutoff frequencies. Based on the extreme anisotropy, the unique phenomena of directive emission, nearly perfect bending waveguides and arbitrary control of energy flux are demonstrated. Interestingly, subwavelength focusing of energy flux with a spotsize <0.2λ is observed (λ is the wavelength in free space). Our work provides a convenient approach for the realization of extremely anisotropic epsilon-near-zero media and unique applications in low-loss waveguide metamaterials.

17.
J Agric Food Chem ; 67(38): 10553-10562, 2019 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-31490076

RESUMO

Chlorpyrifos (CPF) is a widely used organophosphorus pesticide and detected frequently in fruits, vegetables, as well as in urine and blood in humans. Studies have suggested that CPF can induce metabolic disruption, such as type-2 diabetes mellitus and changed body weight. The main mechanisms are based on oxidative damage, fatty-acid synthesis, and lipid peroxidation. Studies have also shown that CPF can change reproductive hormone (RH) levels. CPF might result in metabolic disorders through altered RH levels. Here, we review the studies showing that CFP causes metabolic disruption. Then, we present the studies showing that CFP changes RH levels. Finally, we discuss a potential pathway of how CPF elicits metabolic disruption.


Assuntos
Clorpirifos/toxicidade , Hormônios Gonadais/metabolismo , Inseticidas/toxicidade , Doenças Metabólicas/metabolismo , Animais , Humanos , Peroxidação de Lipídeos , Doenças Metabólicas/etiologia
18.
J Hazard Mater ; 383: 121115, 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31525682

RESUMO

It is more economical and feasible to harvest above-ground plant tissues, especially leaves, than to uproot the entire plant during phytoremediation. The major goal of this study is to estimate the promoting effect of an external magnetic field on soil Cadmium (Cd) remediation efficiency by harvesting the leaves of Festuca arundinacea, irrigated by normal and magnetized water. Changes in the amount of emerging, mature, senescent, and dead leaves, as well as Cd concentrations in the corresponding tissues were compared. It was found that F. arundinacea irrigated by either kind of water accumulated significantly more Cd in senescent and dead leaves than in other tissues. After irrigation with magnetized water, the biomass of senescent and dead leaves increased from 15.7 and 6.4% to 17.2 and 11.6%, respectively, and a significantly higher amount of Cd (˜23.6%) was redistributed into dead leaves compared with the control. Thus, significantly more Cd was removed by harvesting the senescent and dead leaves of F. arundinacea. These results indicate that magnetic fields can increase the phytoremediation efficiency of F. arundinacea for Cd, and simultaneously reduce the cost of harvested residue disposal.

19.
Chin Med J (Engl) ; 132(18): 2265-2267, 2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31490261
20.
J Transl Med ; 17(1): 323, 2019 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-31547829

RESUMO

PURPOSE: To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Three electronic databases: PubMed, EMbase and EBSCOhost CINAHL, were searched for observational studies to measure the relationship between serum levels of vitamin D (VitD) and CD (or UC). RESULTS: Fifty-five studies were included in the meta-analysis. We found that mean serum 25(OH)D levels in patients with CD were significantly lower than those in healthy controls (MD: - 3.17 ng/mL; 95% CI - 4.42 to - 1.93). Results from the meta-analysis examining 1,25(OH)2D3 levels in Crohn's patients revealed higher levels in the CD group than in healthy (MD: 3.47 pg/mL; 95% CI - 7.72 to 14.66) and UC group (MD: 5.05 pg/mL; 95% CI - 2.42 to 12.52). Serum 25(OH)D levels were lower in the UC group than in the healthy control group (MD: - 2.52 ng/mL; 95% CI - 4.02 to - 1.02). In studies investigating the level of 1,25(OH)2D3 in UC and healthy control groups, the level of 1,25(OH)2D3 in the UC groups were found to be higher than that in the control groups (MD: 3.76 pg/mL; 95% CI - 8.36 to 15.57). However, the 1,25(OH)2D3 level in patients with UC was lower than that in CD groups (MD: - 6.71 pg/mL; 95% CI - 15.30 to 1.88). No significant difference was noted between CD patients and UC patients in terms of average serum 25(OH)D levels. CONCLUSIONS: This study found that VitD levels were inversely related to CD and UC. Serum levels of 25(OH)D were lower in patients with CD and UC than in healthy people, and more than half of the patients had insufficient vitamin D levels. The serum level of 1,25(OH)2D3 in both the CD and UC groups was higher than that in healthy people.

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