Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.910
Filtrar
1.
Neural Regen Res ; 17(6): 1299-1309, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34782575

RESUMO

During acute reperfusion, the expression profiles of long noncoding RNAs in adult rats with focal cerebral ischemia undergo broad changes. However, whether long noncoding RNAs are involved in neuroprotective effects following focal ischemic stroke in rats remains unclear. In this study, RNA isolation and library preparation was performed for long noncoding RNA sequencing, followed by determining the coding potential of identified long noncoding RNAs and target gene prediction. Differential expression analysis, long noncoding RNA functional enrichment analysis, and co-expression network analysis were performed comparing ischemic rats with and without ischemic postconditioning rats. Rats were subjected to ischemic postconditioning via the brief and repeated occlusion of the middle cerebral artery or femoral artery. Quantitative real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of differentially expressed long noncoding RNAs after ischemic postconditioning in a rat model of ischemic stroke. The results showed that ischemic postconditioning greatly affected the expression profile of long noncoding RNAs and mRNAs in the brains of rats that underwent ischemic stroke. The predicted target genes of some of the identified long noncoding RNAs (cis targets) were related to the cellular response to ischemia and stress, cytokine signal transduction, inflammation, and apoptosis signal transduction pathways. In addition, 15 significantly differentially expressed long noncoding RNAs were identified in the brains of rats subjected to ischemic postconditioning. Nine candidate long noncoding RNAs that may be related to ischemic postconditioning were identified by a long noncoding RNA expression profile and long noncoding RNA-mRNA co-expression network analysis. Expression levels were verified by quantitative real-time reverse transcription-polymerase chain reaction. These results suggested that the identified long noncoding RNAs may be involved in the neuroprotective effects associated with ischemic postconditioning following ischemic stroke. The experimental animal procedures were approved by the Animal Experiment Ethics Committee of Kunming Medical University (approval No. KMMU2018018) in January 2018.

2.
J Colloid Interface Sci ; 607(Pt 2): 1908-1918, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34798707

RESUMO

The utilization of mechanical energy to control water pollutants under dark conditions is currently a point of study focus. Herein, biochar -zinc oxide (BC-ZnO) composites with various structures were synthesized by co-pyrolysis of cotton and ZnO at different temperature and used for tribo-catalytic reaction. The introduction of BC can improve charge transmission and separation efficiency. Ultraviolet photoelectron spectra (UPS) and density functional theory (DFT) calculation prove the addition of BC can reduce work function of ZnO, and enhance its electron-donating ability. Specially, suitable adsorption amount is the key factor to improve the tribo-catalytic performance. When the pyrolysis temperature is 600 °C, BC-ZnO has the best degradation efficiency, which can degrade 90% Rhodamine B (RhB) in 75 min, while ZnO can degrade only 38%. On this basis, using bovine serum albumin (BSA) as a model, the effect of tribo-catalytic reaction on controlling proteins in water was studied by fluorescence excitation-emission matrix spectroscopy (3D EEM) and infrared microscope, and the transformation of proteins was further analyzed. This study provides a new strategy to improve the tribo-catalytic performance of ZnO, and explores its application prospects of biological wastewater control.


Assuntos
Poluentes Químicos da Água , Óxido de Zinco , Adsorção , Catálise , Carvão Vegetal
3.
J Exp Bot ; 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34727176

RESUMO

Vegetable oils are indispensable nutritional components of human diet as well as important raw materials for a variety of industrial applications such as pharmaceuticals, cosmetics, oleochemicals and biofuels. The oil plant genomes are highly diverse, and the genetic variation leads to the diversity in oil biosynthesis and accumulation along with agronomic traits. This review discusses the plant oil biosynthetic pathways, the current state of genome assembly, the polyploidy and asymmetric evolution genomes of oil plants and their wild relatives, and the research progress of pan-genomics in oil plants. The availability of complete high-resolution genomes and pangenomes has enabled the identification of structural variations in the genomes that are associated with the diversity of agronomic and environment fitness traits. These and more future genomes also provide powerful tools to understand crop evolution and to harvest the rich natural variations to improve oil crops for enhanced productivity, oil quality, and adaptability to changing environments.

4.
Plant Physiol ; 2021 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-34730798

RESUMO

Dehydration damages the structural integrity of the chloroplast membrane and, consequently, the normal photosynthetic function of this organelle. Remodeling of galactolipids by converting monogalactosyl-diacylglycerol (MGDG) to digalactosyl-diacylglycerol (DGDG) and oligo-galactolipids is an effective adaptation strategy for protecting against dehydration damage to the chloroplast membrane. However, detailed molecular mechanisms are missing. In this study, by performing molecular-level simulations of bi-lamellar membranes under various dehydration conditions, we find that MGDG-to-DGDG remodeling protects the chloroplast membrane in a unique manner by simultaneously dictating both the extent and the pattern of fusion stalks formed with the apposed membrane. Specifically, MGDG-rich membranes form elongated stalks at a moderate dehydration level, whereas DGDG-rich membranes form smaller, rounded stalks. Simulations of wild-type and mutant Arabidopsis (Arabidopsis thaliana) outer chloroplast membranes further confirm that the mutant membrane without galactolipid remodeling is more susceptible to membrane fusion due to its higher MGDG content. Our work reveals the underlying physical mechanisms that govern the pattern and extent of membrane fusion structures, paving the way for rational genetic engineering of crops with improved dehydration tolerance.

5.
Front Oncol ; 11: 722624, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34778038

RESUMO

Ribophorin 1 (RPN1) is a major part of Oligosaccharyltransferase (OST) complex, which is vital for the N-linked glycosylation. Though it has been verified that the abnormal glycosylation is closely related to the development of breast cancer, the detail role of RPN1 in breast cancer remains unknown. In this study, we explored the public databases to investigate the relationship between the expression levels of OST subunits and the prognosis of breast cancer. Then, we focused on the function of RPN1 in breast cancer and its potential mechanisms. Our study showed that the expression of several OST subunits including RPN1, RPN2, STT3A STT3B, and DDOST were upregulated in breast cancer samples. The protein expression level of RPN1 was also upregulated in breast cancer. Higher expression of RPN1 was correlated with worse clinical features and poorer prognosis. Furthermore, knockdown of RPN1 suppressed the proliferation and invasion of breast cancer cells in vitro and induced cell apoptosis triggered by endoplasmic reticulum stress. Our results identified the oncogenic function of RPN1 in breast cancer, implying that RPN1 might be a potential biomarker and therapeutic target for breast cancer.

6.
Ann Diagn Pathol ; 56: 151847, 2021 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-34742033

RESUMO

Muscle-invasive bladder carcinoma (MIBC) accounts for 25% of newly diagnosed bladder carcinomas (BCs) and presents a high risk of progression and metastasis. This study aimed to identify reliable biomarkers associated with muscle invasion and prognosis to identify potential therapeutic targets for MIBC. Four gene datasets were downloaded from the Gene Expression Omnibus, and the integrated differentially expressed genes (DEGs) were then subjected to gene ontology (GO) terms and pathway enrichment analyses. Correlation analysis between the expression of the top-ranking DEGs and pathological T stages was performed to identify the genes associated with early muscle invasion. The corresponding prognostic values were evaluated, and co-expressed genes mined in the cBioPortal database were loaded into ClueGo in Cytoscape for pathway enrichment analysis. Using data mining from the STRING and TCGA databases, protein-protein interaction and competitive endogenous RNA networks were constructed. In total, 645 integrated DEGs were identified and these were mainly enriched in 26 pathways, including cell cycle, bladder cancer, DNA replication, and PPAR signaling pathway. S100A7 expression was significantly increased from the T2 stage and showed significantly worse overall survival and disease-specific survival in patients with BC. In total, 144 genes co-expressed with S100A7 in BC were significantly enriched in the IL-17 pathway. S100A7 was predicted to directly interact with LYZ, which potentially shows competitive binding with hsa-mir-140 to affect the expression of six lncRNAs in MIBC. In conclusion, high S100A7 expression was predicted to be associated with early muscle invasion and poor survival in patients with BC.

7.
Polymers (Basel) ; 13(21)2021 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-34771325

RESUMO

Intelligent structural colors have received extensive attention in recent years due to their diverse applications. However, the large-area, uniform, and cost-effective fabrication of ultra-thin structural color films is still challenging. Here, for the first time, we design and employ an ultrasonic spray-coating technique with non-toxic, green nano-silica and polyvinylpyrrolidone as raw materials, to prepare structural color films on silicon wafers. Due to the addition of polyvinylpyrrolidone, the coffee-ring effect during droplet drying is suppressed and uniform composite films are formed. We further perform a detailed study of the influence of various processing parameters including silica/polyvinylpyrrolidone concentration, substrate temperature, nozzle-to-substrate distance, and number of spray-passes on film roughness and thickness. By increasing the number of spray-passes from 10 to 30, the film thickness from 120 to 340 nm is modulated, resulting in different colors, and large-area and uniform colors on commercial round silicon wafers with 15 cm diameter are achieved. The silica/polyvinylpyrrolidone composite films show strong hydrophilicity and are sensitive to humidity changes, leading to quickly tunable and reversible structural colors. Quartz crystal microbalance with dissipation demonstrates water vapor adsorption and condensation on the nanofilm when increasing environmental humidity. Thereby, ultrasonic spray-coating as a novel film fabrication technique provides a feasible scheme for large-area preparation of intelligent structural colors.

8.
Front Cell Dev Biol ; 9: 740487, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34760888

RESUMO

Background: Lung cancer is the leading cause of cancer-related death worldwide, of which lung adenocarcinoma (LUAD) is one of the main histological subtypes. Mitochondria are vital for maintaining the physiological function, and their dysfunction has been found to be correlated with tumorigenesis and disease progression. Although, some mitochondrial-related genes have been found to correlate with the clinical outcomes of multiple tumors solely. The integrated relationship between nuclear mitochondrial genes (NMGs) and the prognosis of LUAD remains unclear. Methods: The list of NMGs, gene expression data, and related clinical information of LUAD were downloaded from public databases. Bioinformatics methods were used and obtained 18 prognostic related NMGs to construct a risk signature. Results: There were 18 NMGs (NDUFS2, ATP8A2, SCO1, COX14, COA6, RRM2B, TFAM, DARS2, GARS, YARS2, EFG1, GFM1, MRPL3, MRPL44, ISCU, CABC1, HSPD1, and ETHE1) identified by LASSO regression analysis. The mRNA expression of these 18 genes was positively correlated with their relative linear copy number alteration (CNA). Meanwhile, the established risk signature could effectively distinguish high- and low-risk patients, and its predictive capacity was validated in three independent gene expression omnibus (GEO) cohorts. Notably, a significantly lower prevalence of actionable EGFR alterations was presented in patients with high-risk NMGs signature but accompanied with a more inflame immune tumor microenvironment. Additionally, multicomponent Cox regression analysis showed that the model was stable when risk score, tumor stage, and lymph node stage were considered, and the 1-, 3-, and 5-year AUC were 0.74, 0.75, and 0.70, respectively. Conclusion: Together, this study established a signature based on NMGs that is a prognostic biomarker for LUAD patients and has the potential to be widely applied in future clinical settings.

9.
Adv Mater ; : e2108090, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34784077

RESUMO

Wide bandgap non-fullerene acceptors with non-fused conjugated structures play a critical role in organic photovoltaic cells. Here, the non-fullerene acceptors named GS-OEH, GS-OC6 and GS-ISO with the optical bandgaps larger than 1.70 eV are synthesized without using the fused ring structures. Compared with GS-OEH and GS-OC6, GS-ISO exhibits much stronger crystallinity, leading to a smaller energetic disorder and a larger exciton diffusion coefficient. GS-ISO also possesses a higher electroluminescence external quantum efficiency of 1.0×10-2 . The organic photovoltaic cell based on PBDB-TF:GS-ISO demonstrates a power conversion efficiency of 11.62% under the standard one sun illumination. Besides, the PBDB-TF:GS-ISO-based cell with the effective area of 1.0 cm2 exhibits a power conversion efficiency of 28.37% under the 2700 K illumination of 500 lux. The tandem organic photovoltaic cell using PBDB-TF:GS-ISO as the front sub-cell shows an outstanding efficiency of 19.10%. Importantly, the GS-ISO-based organic photovoltaic cell exhibits promising stability under the continuous illumination of the simulated sunlight. This study indicates that the molecular design strategy demonstrated in this work has great superiority in developing non-fused non-fullerene acceptors and also GS-ISO is a promising wide bandgap acceptor for versatile photovoltaic applications. This article is protected by copyright. All rights reserved.

10.
Chemphyschem ; 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34791762

RESUMO

The adding of insulating polymers into conjugated polymers is an efficient strategy to tailor their mechanical properties for flexible organic electronics. In this work, we selected two insulating polymers as additives into high-performance photoactive layers to study the mechanical and photovoltaic properties in organic solar cells (OSCs). The insulating polymers were found to reduce the electron mobilities in the photoactive layers, and hence the power conversion efficiencies were significantly decreased. More importantly, we found that the insulating polymers exhibited negative effect on the mechanical properties of the photoactive layers, with reduced young's modules and low crack onset strain. Further studies revealed that the insulating polymers had poor miscibility with the photoactive layers, providing large domains in blend thin films, which act as the force accumulation point during the tensile test. The studies indicate that rational selection of insulating polymers, especially enhancing the non-covalent interaction with the photoactive layers, will be critically important for the stretch OSCs.

11.
Artigo em Inglês | MEDLINE | ID: mdl-34770015

RESUMO

BACKGROUND: Intensive care unit (ICU) patients experience multiple uncomfortable symptoms, which may be alleviated using music-based intervention, a nondrug treatment. This umbrella review aims to combine the data of systematic reviews and/or meta-analyses to evaluate the effectiveness of music-based intervention in improving uncomfortable symptoms in ICU patients. METHODS: A comprehensive literature search was performed on the PubMed, Embase, Cochrane Library, Airiti Library, CINAHL, ProQuest, and Web of Science databases, and Epistemonikos. The search had no language restrictions, and articles on the improvement of symptoms using music-based intervention in adult ICU patients were included. This review protocol was registered on PROSPERO (CRD42021240327). RESULTS: This umbrella review retrieved 5 systematic reviews and 41 original studies, including 39 randomized controlled trials, and 2 nonrandomized controlled trials. Diverse music was the most common music type used for music-based intervention, the intervention music was typically decided by the study participants (61%), and most subjects underwent one intervention session (78%). Furthermore, most music intervention sessions lasted for 30 min (44%). The positive results included decreased anxiety, decreased pain, decreased agitation, decreased anesthesia dose and sedative use, decreased chances of delirium, decreased feelings of uncomfort, and improved sleep quality. CONCLUSIONS: A systematic review on the effectiveness of music-based intervention in improving uncomfortable symptoms in ICU patients revealed that 20-30 min intervention sessions showed the best improvement in the uncomfortable symptoms in patients. This study provides a basis for using music-based intervention to relieve the uncomfortable symptoms in critically ill ICU patients, and a reference for empirical clinical practice.


Assuntos
Música , Adulto , Cuidados Críticos , Estado Terminal , Humanos , Unidades de Terapia Intensiva , Revisões Sistemáticas como Assunto
12.
Fungal Genet Biol ; 158: 103637, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34798271

RESUMO

Beauveria bassiana is a well-known entomopathogenic fungus that parasitizes on a variety of insect species. Glucan in the cell wall of B. bassiana plays a crucial role in its structure and growth and is also involved in the activation of the host insect's immune system. Glucan biosynthesis is primarily regulated by glucan synthase, however, it is unclear if the glucan synthase catalytic subunit gene (GluS) affects the growth and virulence of B. bassiana. In this study, we constructed the mutant of the B. bassiana glucan synthase catalytic subunit (ΔGluS) by homologous recombination and observed that glucan synthase knockout affects both spore germination and cell area. Further enzyme-based assays along with gene expression analysis of glucan synthase revealed a significant downregulation in the mutant strains compared to the wild type of B. bassiana. Moreover, the virulence of ΔGluS strains against gypsy moth (Lymantria dispar) showed no significant difference compared to the wild-type strains when injected, while the spraying gypsy moths with the conidia of ΔGluS was significantly more lethal than spraying the conidia of the wild type. Altogether, our study constructed a new, highly efficient B. bassiana mutant that can be used for pest control and provides a readily transferable method for other insect-entomopathogenic interaction studies.

13.
PLoS One ; 16(11): e0259240, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34735498

RESUMO

INTRODUCTION: In the past 22 years, a large number of publications have reported that liver kinase B1 (LKB1) can regulate a variety of cellular processes and play an important role in many diseases. However, there is no systematic bibliometric analysis on the publications of LKB1 to reveal the research hotspots and future direction. METHODS: Publications were retrieved from the Web of Science Core Collection (WoSCC), Scopus, and PubMed databases. CiteSpace and VOSviewer were used to analysis the top countries, institutions, authors, source journals, discipline categories, references, and keywords. RESULTS: In the past 22 years, the number of LKB1 publications has increased gradually by year. The country, institution, author, journals that have published the most articles and cited the most frequently were the United States, Harvard University, Prof. Benoit Viollet, Journal of Biochemistry and Plos One. The focused research hotspot was the molecular functions of LKB1. The emerging hotspots and future trends are the clinical studies about LKB1 and co-mutated genes as biomarkers in tumors, especially in lung adenocarcinoma. CONCLUSIONS: Our research could provide knowledge base, frontiers, emerging hotspots and future trends associated with LKB1 for researchers in this field, and contribute to finding potential cooperation possibilities.

14.
Front Genet ; 12: 769888, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34745233

RESUMO

The major facilitator superfamily (MFS) is one of the largest known membrane transporter families. MFSs are involved in many essential functions, but studies on the MFS family in poplar have not yet been reported. Here, we identified 41 MFS genes from Populus trichocarpa (PtrMFSs). We built a phylogenetic tree, which clearly divided members of PtrMFS into six groups with specific gene structures and protein motifs/domains. The promoter regions contain various cis-acting elements involved in stress and hormone responsiveness. Genes derived from segmental duplication events are unevenly distributed in 17 poplar chromosomes. Collinearity analysis showed that PtrMFS genes are conserved and homologous to corresponding genes from four other species. Transcriptome data indicated that 40 poplar MFS genes were differentially expressed when treated with Fusarium oxysporum. Co-expression networks and gene function annotations of MFS genes showed that MFS genes tightly co-regulated and closely related in function of transmembrane transport. Taken together, we systematically analyzed structure and function of genes and proteins in the PtrMFS family. Evidence indicated that poplar MFS genes play key roles in plant development and response to a biological stressor.

15.
Nano Lett ; 21(21): 9115-9123, 2021 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-34723551

RESUMO

Drug resistance remains the dominant impediment for cancer therapy, not only because compensatory drug resistance pathways are always activated, but also because of the cross-resistance of cancer cells to unrelated therapeutics. Herein, chemodrug-sensitive cancer cells, intrinsic drug-resistant cells, and acquired resistant cells were employed to uncover their biological response to a nanoparticle-based photodynamic method in tumoral, cellular, and molecular levels. We observed that nanoparticle-based photodynamic process with high therapeutic efficiency, intracellular delivery, and tumor penetration effect resulted in the indiscriminate and significant therapeutic outcome, in contrast to the diversiform effect of first-line chemo-drug, Temozolomide (TMZ). By real-time quantitative PCR array technique, we revealed that signals in classical resistance pathways were unaffected or downregulated, and photodynamic effect initiates cell apoptosis via downstream genes. The discovery that nanoparticulate photodynamic therapy bypasses the signals in multiple resistant pathways may imply an alternative route for combating drug resistance of cancer.

16.
PeerJ ; 9: e12126, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34603851

RESUMO

Background: Diabetic retinopathy (DR) is characterized by a gradually progressive alteration in the retinal microvasculature that leads to middle-aged adult acquired persistent blindness. Limited research has been conducted on DR pathogenesis at the gene level. Thus, we aimed to reveal novel key genes that might be associated with DR formation via a bioinformatics analysis. Methods: The GSE53257 dataset from the Gene Expression Omnibus was downloaded for gene co-expression analysis. We identified significant gene modules via the Weighted Gene Co-expression Network Analysis, which was conducted by the Protein-Protein Interaction (PPI) Network via Cytoscape and from this we screened for key genes and gene sets for particular functional and pathway-specific enrichments. The hub gene expression was verified by real-time PCR in DR rats modeling and an external database. Results: Two significant gene modules were identified. Significant key genes were predominantly associated with mitochondrial function, fatty acid oxidation and oxidative stress. Among all key genes analyzed, six up-regulated genes (i.e., SLC25A33, NDUFS1, MRPS23, CYB5R1, MECR, and MRPL15) were highly and significantly relevant in the context of DR formation. The PCR results showed that SLC25A33 and NDUFS1 expression were increased in DR rats modeling group. Conclusion: Gene co-expression network analysis highlights the importance of mitochondria and oxidative stress in the pathophysiology of DR. DR co-expressing gene module was constructed and key genes were identified, and both SLC25A33 and NDUFS1 may serve as potential biomarker and therapeutic target for DR.

17.
PeerJ Comput Sci ; 7: e704, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34604526

RESUMO

Unlike traditional visualization methods, augmented reality (AR) inserts virtual objects and information directly into digital representations of the real world, which makes these objects and data more easily understood and interactive. The integration of AR and GIS is a promising way to display spatial information in context. However, most existing AR-GIS applications only provide local spatial information in a fixed location, which is exposed to a set of problems, limited legibility, information clutter and the incomplete spatial relationships. In addition, the indoor space structure is complex and GPS is unavailable, so that indoor AR systems are further impeded by the limited capacity of these systems to detect and display location and semantic information. To address this problem, the localization technique for tracking the camera positions was fused by Bluetooth low energy (BLE) and pedestrian dead reckoning (PDR). The multi-sensor fusion-based algorithm employs a particle filter. Based on the direction and position of the phone, the spatial information is automatically registered onto a live camera view. The proposed algorithm extracts and matches a bounding box of the indoor map to a real world scene. Finally, the indoor map and semantic information were rendered into the real world, based on the real-time computed spatial relationship between the indoor map and live camera view. Experimental results demonstrate that the average positioning error of our approach is 1.47 m, and 80% of proposed method error is within approximately 1.8 m. The positioning result can effectively support that AR and indoor map fusion technique links rich indoor spatial information to real world scenes. The method is not only suitable for traditional tasks related to indoor navigation, but it is also promising method for crowdsourcing data collection and indoor map reconstruction.

18.
Asian J Surg ; 2021 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-34642052

RESUMO

PURPOSE: Currently, the early diagnosis of second primary cancers (SPCs) after gastric cancer (GC) remains a thorny problem. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been demonstrated to participate in the development of GC. Thus, we investigated diagnostic values of NLR and PLR in SPCs after GC. MATERIALS AND METHODS: 78 patients with SPCs after GC, 99 patients with single GC and 107 healthy controls were retrospectively analyzed between 2011 and 2021. We detected their hematological parameters, plotted receiver operating characteristic curves of NLR, PLR, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) alone or in combination for SPCs, and compared area under the curve (AUC). RESULTS: SPC patients had higher levels of NLR, PLR, CEA and CA19-9 than other groups, and all indicators increased synchronically with GC progression. Compared with single GC patients, SPC patients had higher NLR levels in each TNM stage and higher PLR levels in stage II-IV. Moreover, NLR and PLR levels in stage I of SPC patients were significantly higher than those in stage IV of single GC patients. The diagnostic efficiency of NLR (AUC = 0.845) and PLR (AUC = 0.796) was significantly higher than that of CEA (AUC = 0.672) and CA19-9 (AUC = 0.655) in SPCs. Pairwise combination had superior diagnostic performance for SPCs, with the largest being NLR combined with PLR (AUC = 0.881). CONCLUSIONS: Clinically, existing diagnostic methods can be combined with NLR and PLR in early diagnosing SPCs after GC.

19.
Chemosphere ; 288(Pt 2): 132400, 2021 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-34597629

RESUMO

A novel biochar electrode Bio-Fe3O4/CF used for electroreduction of nitrate was prepared by the hydrothermal synthesis method. The results showed that the growth of spherical Fe3O4 on the surface of smooth biochar can significantly increase the nitrate reduction rate. Besides, the presence of Cl and Br in the solution could promote the conversion of NH4+ to N2, thereby regulating the element nitrogen in the solution. Mechanistic analysis showed that the interconversion of Fe (II) and Fe (III) facilitates the transfer of electrons to nitrate. This study not only provides a biochar electrode material for the efficient removal of nitrate but also simply reveals regulation of halogen in solution, which provides a particular theoretical and data basis for nitrate removal.

20.
Small ; : e2103537, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34655164

RESUMO

The thermal stability of high-efficiency organic photovoltaics (OPVs) is critical to the manufacturing of this technology. Therefore, targeted strategies and approaches shall be developed to improve efficiency and stability, simultaneously. Herein, a seleno twisted benzodiperylenediimides (TBD-PDI-Se) acceptor-doping strategy is taken advantage of to demonstrate the ternary bulk heterojunction OPVs with excellent stability, achieving outstanding power conversion efficiency of 14.43% and 17.25% based on PM6:IT-4F and PM6:Y6 ternary blend devices, respectively, which are superior to the corresponding binary devices. As evidenced by the active layer morphology, exciton dynamic study and the characterizations of the enabled device, the ternary blend device keeps nearly 90% original efficiency (t = 1000 h) under continuous constant heating at 140 °C. Furthermore, the application of acceptor as the third component in PBDB-T:ITIC, J71:ITIC, and PBDB-T:PC71 BM systems is also verified, proving the good universality of acceptor-doping ternary strategy.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...