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1.
J Hazard Mater ; 467: 133663, 2024 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-38325095

RESUMO

Incorporating spent coffee grounds into single-use drinking straws for enhanced biodegradability also raises safety concerns due to increased chemical complexity. Here, volatile organic compounds (VOCs) present in coffee ground straws (CGS), polylactic acid straws (PLAS), and polypropylene straws (PPS) were characterized using headspace - solid-phase microextraction and migration assays, by which 430 and 153 VOCs of 10 chemical categories were identified by gas chromatography - mass spectrometry, respectively. Further, the VOCs were assessed for potential genetic toxicity by quantitative structure-activity relationship profiling and estimated daily intake (EDI) calculation, revealing that the VOCs identified in the CGS generally triggered the most structural alerts of genetic toxicity, and the EDIs of 37.9% of which exceeded the threshold of 0.15 µg person-1 d-1, also outnumbering that of the PLAS and PPS. Finally, 14 VOCs were prioritized due to their definite hazards, and generally higher EDIs or detection frequencies in the CGS. Meanwhile, the probability of producing safer CGS was also illustrated. Moreover, it was uncovered by chemical space that the VOCs with higher risk potentials tended to gather in the region defined by the molecular descriptor related to electronegativity or octanol/water partition coefficient. Our results provided valuable references to improve the chemical safety of the CGS, to promote consumer health, and to advance the sustainable development of food contact materials.


Assuntos
Café , Compostos Orgânicos Voláteis , Humanos , Alimentos , Cromatografia Gasosa-Espectrometria de Massas , Octanóis , Polipropilenos
2.
Food Chem ; 440: 138264, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38150902

RESUMO

A simple ultrasonic synthesis strategy was developed for a novel magnetic covalent organic framework. Firstly, the Fe3O4 nanoparticles were encapsulated by imine-type COF, which generated by the Schiff reaction of 4,4',4''-(1,3,5-Triazine-2,4,6-triyl)-trianiline (TAPT) and tris(4-formylphenyl)-amine (TFPA) using ultrasonic synthesis method within 2 h. The synthesised nanocomposites showed a sizeable specific surface area, and high adsorption capacity. A fast, sensitive MSPE method with Fe3O4@TAPT-TFPA-COF as adsorbent for analysing bisphenol compounds was developed. This method's advantages were simple operation, short extraction time, and avoidance of the use of centrifugal equipment. The method validation indicate that this method exhibited superior linearity, and detection limits range between 0.33 and 0.60 µg L-1. The recoveries of BPs ranged from 74.7 % to 107.0 %, with relative standard deviations of less than 3.8 % in water, milk, vinegar, and soy sauce samples. The proposed method was successfully applied for extracting BPs in food samples.


Assuntos
Estruturas Metalorgânicas , Adsorção , Ultrassom , Fenômenos Magnéticos , Extração em Fase Sólida/métodos , Cromatografia Líquida de Alta Pressão , Limite de Detecção
3.
Foods ; 12(16)2023 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-37628128

RESUMO

Ethyl carbamate (EC) is carcinogenic, and, in China, oral intake of EC mainly occurs as a result of the consumption of alcoholic beverages. To obtain the latest EC intake and risk analysis results for the general population in China, the China National Center for Food Safety Risk Assessment (CFSA) conducted the sixth total diet study (TDS) as a platform to analyze EC contents and exposure due to the intake of alcoholic beverages. A total of 100 sites in 24 provinces were involved in the collection and preparation of alcohol mixture samples for the sixth TDS. There were 261 different types of alcohol collected across the country, based on local dietary menus and consumption survey results. Ultimately, each province prepared a mixed sample by mixing their respective samples according to the percentage of local consumption. The EC levels of these twenty-four mixed samples were determined using our well-validated gas chromatography-mass spectrometry (GC-MS) method. The values ranged from 1.0 µg/kg to 33.8 µg/kg, with 10.1 µg/kg being the mean. China's EC daily intake ranged from 0.001 ng/kg bw/d to 24.56 ng/kg bw/d, with a mean of 3.23 ng/kg bw/d. According to the margin of exposure (MOE), virtually safe dose (VSD), and T25 risk assessments of the carcinogenicity of EC, the mean lifetime cancer risk for the Chinese population was 9.8 × 104, 1.5 × 10-7, and 8.6 × 10-8, respectively. These data show that the carcinogenicity of EC in the general Chinese population due to alcoholic intake is essentially minimal.

4.
Nutrients ; 15(14)2023 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-37513616

RESUMO

Antibiotic resistance genes (ARGs) threaten the success of modern drugs against multidrug resistant infections. ARGs can be transferred to opportunistic pathogens by horizontal gene transfer (HGT). Many studies have investigated the characteristics of ARGs in various chemical stressors. Studies on the effects of dietary nutrition and dietary patterns on ARGs are rare. The study first demonstrated the effect of calorie restricted (CR) diet on the ARGs and mobile genetic elements (MGEs) in mouse feces and explored their relationship with gut microbiota and their functions. The results showed that the abundance of the total ARGs in mouse feces of the CR group increased, especially tetracycline ARGs (tetW-01). The abundance of the MLSB ARGs (ermB) decreased evidently in mouse feces of the CR group. In addition, the total abundance of MGEs decreased evidently in the CR group, especially tnpA-03. In the meantime, the abundance of Lactobacillus and Bifidobacterium in mouse feces of the CR group increased remarkably. The Spearman correlation analysis between gut microbiota and ARGs showed that several probiotics were significantly positively correlated with ARGs (tetW-01), which might be the main contribution to the increase in ARGs of the CR group.


Assuntos
Antibacterianos , Genes Bacterianos , Animais , Camundongos , Antibacterianos/farmacologia , Restrição Calórica , Esterco/microbiologia , Resistência Microbiana a Medicamentos/genética
5.
Nutrients ; 15(11)2023 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-37299405

RESUMO

The sixth Total Diet Study (TDS) of China included a countrywide study to assess the health effects of MSG (monosodium glutamate). MSG detection, consumption analysis, and risk assessment were conducted on 168 samples from seven food categories of the most typical Chinese daily diet. The highest value of MSG in the daily diet of the Chinese population was 8.63 g/kg. An MSG intake of 17.63 mg/kg bw/d for the general population of China was obtained from content measurements combined with food consumption, while the data from the apparent consumption survey alone gave 40.20 mg/kg bw/d. The apparent consumption did not consider the loss of MSG during food cooking, resulting in an overestimate. To offer a global perspective, MSG content, food category contributions, and ingestion levels across nations were summarized and thoroughly investigated. A realistic, logical, and precise risk assessment protocol for MSG daily intake was developed in this article.


Assuntos
Dieta , Glutamato de Sódio , Humanos , Glutamato de Sódio/efeitos adversos , Alimentos , Medição de Risco , China/epidemiologia
6.
J Environ Sci (China) ; 125: 641-649, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36375946

RESUMO

Exposure to endocrine disruptors (EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and urinary levels of 11 EDCs, including six phthalate metabolites, bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), perchlorate, and thiocyanate among 177 healthy adults without occupational exposure. Associations of multiple urinary analytes with serum thyroid hormones were examined by performing general linear regression analysis and bayesian kernal machine regression analysis. These EDCs were detected in almost all samples. After adjusting for various covariates, we observed only BPF significantly associated with total thyroxin (TT4) (ß=-0.27, 95% confidence interval (CI) [-0.41, -0.14]), total triiodothyronine (TT3) (ß=-0.02 95% CI [-0.03, -0.01]), free T4 (fT4) (ß=-0.02, 95% CI [-0.03, -0.01]), and free T3 (fT3) (ß=-0.04, 95% CI [-0.07, -0.01]), and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and monoethyl phthalate (MEP) positively associated with TT4 (ß=0.24, 95% CI [0.01, 0.48]) and fT4 (ß=0.02, 95% CI [0.01, 0.04]), respectively. Moreover, we observed significant dose-response relationships between TT4 and the mixture of 11 EDCs, and BPF was the main contributor to the mixture effect, suggesting the priority of potential effect of BPF on disrupting thyroid function under a real scenario of human exposure to multiple EDCs. Our findings supported the hypothesis that human exposure to low levels of EDCs could alter thyroid hormones homeostasis among non-occupational healthy adults.


Assuntos
Disruptores Endócrinos , Ácidos Ftálicos , Humanos , Adulto , Disruptores Endócrinos/toxicidade , Estudos Transversais , Teorema de Bayes , Ácidos Ftálicos/toxicidade , Hormônios Tireóideos
7.
Sci Total Environ ; 828: 154552, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-35292325

RESUMO

This study analyzed five heavy elements (HEs), including cadmium (Cd), chromium (Cr), mercury (Hg), lead (Pb), and arsenic (As), in fresh vegetables (i.e., legume, rhizome and potato, gourd, bulb, solanaceous fruit, leafy, and brassica; total: 7214) collected from 31 provinces in China from 2016 to the first half of 2017. By analyzing the concentration level of the five HEs in seven regions (the Northeast, North China, East China, South China, Central China, the Northwest, and the Southwest), except for As, average HEs concentrations were higher in the Southwest than that in the other six regions. According to the maximum permissible limit (MPL), the highest rate of HEs concentration above the MPL was found in the Southwest (11.038%). Analysis of variance (ANOVA) showed varying degrees of variability between regions and categories. By using principal component analysis (PCA), it was found that two principal components account for 73.79% of the total variance in the data. Together with hierarchical cluster analysis (HCA), concluded that Tibet was significantly different from the other 30 provinces. By calculating estimated daily intake (EDI) and the target hazard quotient (THQ), the EDI of Cr in the Southwest was the highest, with results of 1.2119 µg/kg/day for children and 0.8073 µg/kg/day for adults. North China had the highest total target hazard quotient (TTHQ) for HEs in vegetables ingested by children, with a result of 0.933.


Assuntos
Arsênio , Mercúrio , Metais Pesados , Poluentes do Solo , Adulto , Arsênio/análise , Criança , China , Monitoramento Ambiental , Contaminação de Alimentos/análise , Humanos , Mercúrio/análise , Metais Pesados/análise , Medição de Risco , Poluentes do Solo/análise , Verduras
8.
Chemosphere ; 241: 125093, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31629241

RESUMO

Some studies have revealed thyrotoxicity of phthalates; however, associations of phthalate exposure with papillary thyroid cancer (PTC) remain unclear. We conducted a pair-matching case-control study of 111 PTC cases and 111 age- and sex-matched non-PTC controls to examine associations between urinary concentrations of phthalate metabolites and PTC. Phthalate metabolites were determined in fasting urine specimens by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS). After adjusting for potential confounders and other phthalate metabolites, the concentrations of the sum of di (2-ethylhexly) phthalate (DEHP) metabolites in urine were positively associated with PTC [odds ratio (OR) = 5.35; 95% confidence interval (CI): 1.61-17.83], suggesting the effect of phthalates exposure on PTC development. The findings require confirmation.


Assuntos
Ácidos Ftálicos/urina , Câncer Papilífero da Tireoide/induzido quimicamente , Neoplasias da Glândula Tireoide/induzido quimicamente , Adulto , Estudos de Casos e Controles , Cromatografia Líquida , Dietilexilftalato/urina , Exposição Ambiental/efeitos adversos , Exposição Ambiental/análise , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Espectrometria de Massas em Tandem , Câncer Papilífero da Tireoide/urina , Neoplasias da Glândula Tireoide/urina
9.
J AOAC Int ; 2018 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-29954479

RESUMO

>Background: A multitude of biomonitoring analytical methods are applied in urinary detection, but few are applicable to phthalate metabolites in human serum, and those that are invariably involve complex operation. Objective: To develop a novel method for the determination of phthalate monoesters in human serum using solid-phase extraction (SPE) and ultra-HPLC (UHPLC)-tandem mass spectrometry for multiple human serum sample determination. Method: Analytes in serum samples were extracted and purified with a novel SPE cartridge named Prime HLB and then directly injected and analyzed without eluent redissolution. After sample extraction and cleanup, 11 phthalate monoesters were separated on a C18 chromatographic column in UHPLC. Among them, mono-isobutyl phthalate and mono-n-butyl phthalate, a pair of isomers, were successfully separated. Results: Lower LODs of the 11 monoesters in 0.5 mL human serum were in the range of 0.03-3 ng/mL, and lower LOQs accordingly ranged from 0.1 to 10.0 ng/mL. Recoveries from spiked bovine serum samples were in the range of 95.3-109.9%, and RSDs were 8.0-12.0%. Intra- and inter-day recoveries were in the range of 94.1-115.7%, with RSDs <13.7%. Conclusions: The proposed method has been proved to be rapid, simple, accurate, and sensitive, so that it may potentially be used for high-throughput biological monitoring with high efficiency and precision. Highlights: Sample pretreatment does not require eluent drying and redissolution. Mass losses of analytes are avoided. Operational procedures are easy and rapid. The method has proved applicable for 11 phthalate metabolites in multiple human serum sample determinations.

10.
Wei Sheng Yan Jiu ; 45(3): 465-9, 2016 May.
Artigo em Chinês | MEDLINE | ID: mdl-27459813

RESUMO

OBJECTIVE: A method was established for determination of 17 kinds of plasticizers in infant formula by solid-phase extraction coupled with UPLC-MS/MS. METHODS: The plasticizers were extracted from the infant formula with acetonitrile, and purified by solid phase extraction column named OASIS Prime HLB. The analytes were then separated by the chromatographic column (BEH Phenyl, 2.1 mm x 100 mm x 1.7 microm). The ion fragment information analytes were obtained using ultra high performance liquid chromatography-tandem mass spectrometry under multiple reaction monitoring mode and the isotope internal standards were used to quantify by calibration curves. RESULTS: The method showed a good linearity (R2 > 0.9990) in the range of 0.5-500 microg/L for 17 plasticizers analytes with average recovery rates of 89.8%-119.0% (n = 6) and the relative standard deviation (RSD) within 3.62%-12.60%. The limits of quantification (LOQ) were between 1 microg/kg and 14 microg/kg. CONCLUSION: The method is simple, sensitive and accurate, and the sample pretreatment is very convenient especially, is suitable for the determination of 17 plasticizers in infant formula and dairy products.


Assuntos
Laticínios/análise , Contaminação de Alimentos , Fórmulas Infantis , Plastificantes/análise , Cromatografia Líquida de Alta Pressão , Extração em Fase Sólida , Espectrometria de Massas em Tandem
11.
Wei Sheng Yan Jiu ; 43(3): 467-71, 487, 2014 May.
Artigo em Chinês | MEDLINE | ID: mdl-24964630

RESUMO

OBJECTIVE: An isotope internal standard analytical process has been developed for the determination of phthalates (PAEs) in Chinese spirits by gas chromatography-mass spectrometry (GC-MS). METHODS: The samples alcoholicity were pre-adjusted after D4-internal standard adjunction, then were extracted with toluene. The supernatant were determined by GC-MS. RESULTS: The calibration curves of 16 phthalates obtained were linear with correlation coefficients greater than 0.997. The calibration curves range from 0.05 - 2 microg/ml. It was effective in the determination of phthalates in Chinese spirits with recoveries of 81.8% - 120% and RSD of 0.711% - 6.63%. The limit of quantification were 0.005 - 0.05 microg/ml. CONCLUSION: The pre-treatment of the process was simple and fast meanwhile the determination was precise. The method has a highly sensitivity. It's suitable for all kinds of phthalates chinese spirits detection.


Assuntos
Bebidas Alcoólicas , Ácidos Ftálicos/análise , Calibragem , Cromatografia Gasosa-Espectrometria de Massas , Humanos
12.
J Agric Food Chem ; 58(5): 3037-42, 2010 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-20151651

RESUMO

Chitin, a major structural component of insect cuticle and fungus cell wall but absent in plants and vertebrates, is regarded as a safe and selective target for pest control agents. Chitin synthesis inhibitors (CSIs) have been well-known as insect growth regulators (IGRs) but rarely found as fungicides in agriculture. To find novel CSIs with good activity, benzoylphenylurea, a typical kind of CSIs, was chosen as the lead compound and 26 novel aryl carbamic acid-5-aryl-2-furanmethyl esters were designed by converting the urea linkages of benzoylphenylureas to carbamic acid esters and changing the aniline parts into furanmethyl groups. The title compounds were synthesized and their structures confirmed by IR, (1)H NMR, and elemental analysis. Preliminary insecticidal and fungicidal bioassays were carried out. The results indicated that the title compounds had no insecticidal effect on Culex pipiens pallens and Plutella xylostella Linnaeus , but most compounds exhibited good fungicidal activities against Corynespora cassiicola , Thanatephorus cucumeris , Botrytis cinerea , and Fusarium oxysporum . In particular, compounds V-4, V-6, V-7, and V-8 showed better activities against the four strains than those of the commercialized fungicides. The morphologic result suggested that compound V-21 had disturbed the cell wall formation of C. cassiicola. The results indicated that modification on the urea linkage of benzoylphenylurea was an effective way to discover new candidates for fungicides.


Assuntos
Carbamatos/química , Fungicidas Industriais/síntese química , Fungicidas Industriais/farmacologia , Ésteres , Espectroscopia de Ressonância Magnética , Espectrofotometria Infravermelho
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