Relationship between Body Mass Index and Serum Alanine Transaminase Concentration in Obese Female.

The serum Alanine Transaminase (ALT) activity has been regarded as a reliable and sensitive marker of liver disease. In the context of obesity ALT may also be a good indicator of overall health. Obesity has been reported as a risk factor associated with elevation of ALT, which is a surrogate marker of Non-alcoholic fatty liver disease (NAFLD). Elevated ALT may correlate with the severity of NAFLD in obese female. This study was done to evaluate the changes of serum ALT in obese female age ranged 30-60 years in comparison to normal healthy female of same age. At the same time we can know the relationship between body mass index and serum ALT concentration in obese female. This analytical cross-sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from January 2020 to December 2020. A total number of 100 female subjects were included in this study. Among them fifty (50) normal healthy female were taken as control group (Group I) and fifty (50) obese female were taken as study group (Group II). The level of serum ALT was determined by Ultra violet (UV) method. Data were expressed as mean±SD and statistical significance of difference among the group was calculated by unpaired Student's 't' test. Pearson's correlation coefficient test was done to find the correlation of serum ALT with BMI by using SPSS (version 21.0). During interpretation of results, p values of <0.001 were considered as statistically highly significant. In this study, serum level of ALT was significantly higher (p<0.001) in obese female compared to those of healthy control female. In addition, there is a positive correlation of serum ALT with BMI. From the results of the present study, it can be concluded that, elevated ALT was significantly associated with high BMI as well as with other feature of NAFLD.

Evaluation of the Status of Glycated Haemoglobin in Male type 2 Diabetic Patients.

The incidence of type 2 diabetes mellitus is increasing in Bangladesh with its attendant complications. Glycated haemoglobin (HbA1c) is broadly used as an index of mean glycaemia. This study was planned to evaluate the status of glycated haemoglobin (HbA1c) in male type 2 diabetic patients. This cross-sectional analytical study was executed in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2019 to June 2020. This study included in total 200 male subjects who are above 40 years in age. Among them, one hundred (100) male type 2 diabetic patients were taken as study group (Group I) and one hundred (100) age matched healthy male subjects were taken as control group (Group II). Glycated haemoglobin was assessed by ion-exchange high performance liquid chromatography (HPLC) method. Mean±SD was used to express data and unpaired Student's 't' test was used to calculate the statistical significance of difference amongst the groups. Pearson's correlation coefficient test was done to correlate the relationship between serum fasting glucose and glycated haemoglobin. The mean±SD of fasting serum glucose of Group I and Group II were 9.79±2.88mmol/L and 5.23±0.48mmol/L respectively. The mean±SD of glycated haemoglobin of Group I and Group II were 8.38±1.28mmol/L and 5.19±0.46mmol/L respectively. The mean±SD of glycated haemoglobin is found to be significantly higher in the study group compared to the control group and there is a positive correlation between fasting serum glucose and glycated haemoglobin. So, routine estimation of this parameter (HbA1c) is important for prevention of complications related to type 2 diabetes mellitus for leading healthy life.

Level of Serum Creatinine and Creatinine Clearance Rate in Obese Female.

The prevalence of obesity continues to increase worldwide day by day causing a serious health problem and impose a significant impact on the National Health Service (NHS) budget. Obesity usually arises from the interactions of multiple genes and lifestyle factors. This study was done to evaluate changes of serum creatinine and creatinine clearance rate in obese female age ranged 30-60 years in comparison to normal healthy female of same age. This study, a cross-sectional analytical type, was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh between the period from January 2020 to December 2020. A total number of 100 female subjects were included in this study. Among them fifty (50) normal healthy female were taken as control group (Group I) and fifty (50) obese female were taken as study group (Group II). To see the level of serum creatinine determined by Kinetic Colorimetric method and creatinine clearance rate was calculated from serum creatinine by Cockcroft-Gault equation. Data was calculated by unpaired Student's't' test and were expressed as mean (±SD). Pearson's correlation coefficient test was done to find the correlation of serum creatinine and creatinine clearance rate with BMI. In this study we found that mean serum Creatinine and Creatinine clearance rate were higher in obese female in comparison to normal healthy female. Again, serum Creatinine and Creatinine clearance rate were positively correlated with BMI. Therefore, to prevent obesity related complications and leading a healthy life we suggest estimations of these parameters routinely.

Association of Body Mass Index and Blood Pressure with Age: A Cross Sectional Study in Elderly Male.

The aim of the study was to assess the status of body mass index (BMI) and blood pressure in elderly male in comparison to younger male and to study the association of BMI and blood pressure with age. This analytical type of cross-sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from January 2019 to December 2019. A total number of 140 male subjects were included in this study. Among them seventy (70) younger males were taken as control group (Group I) and seventy (70) elderly males were taken as study group (Group II). Body mass index (BMI) was calculated as the weight in kilograms divided by the square of the height in meters (kg/m²). Systolic and diastolic blood pressure was measured by aneroid sphygmomanometer (ALPK2, Japan). Data were expressed as Mean±SD and statistical significance of difference among the group was calculated by unpaired student's 't' test. Pearson's correlation coefficient test was done to find the correlation of BMI, systolic blood pressure (SBP) & diastolic blood pressure (DBP) with age. In this study we found that mean BMI, systolic blood pressure & diastolic blood pressure were significantly higher in elderly male persons in comparison to younger male. Although the magnitude of correlation differed, we found that BMI, systolic blood pressure & diastolic blood pressure were positively correlated with age of the subjects. Based on the study carried out it can be concluded that due to aging process geriatric populations are more prone to development of hypertension and other cardiovascular complications than younger individuals.

Relation of Serum Iron Level with Serum Zinc Level among Adolescent Girls with Iron Deficiency Anaemia in Bangladesh.

Adolescent girls are vulnerable in underdeveloped and developing countries due to having public health problems regarding iron deficiency anaemia. As zinc acts as a cofactor in iron metabolism, so the deficiency of this trace element is associated with iron deficiency anaemia. This study was done to evaluate the changes of serum iron and serum zinc levels among iron deficient anaemic adolescent girls in comparison to healthy adolescent girls in Bangladesh. This prospective type of analytical cross sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2019 to December 2020. Total number of 140 adolescent girl's age ranged from10-19 years included in this study. Among them, 70 healthy adolescent girls, were taken as control group (Group I). Remaining 70 Adolescent girls with iron deficiency anaemia (IDA) were taken as study group (Group II). Estimation of serum iron was determined by Ferrozine method using Globals iron kit, UK. Serum zinc levels were determined by colorimetric method with reagents. All data were expressed as mean (±SD) and statistical significance of difference among the group I ( healthy adolescent girls) and group II (adolescent girls with iron deficiency anaemia) were calculated by unpaired students' 't' test. Correlation of serum iron with serum zinc was done by Pearson's correlation coefficient test. The mean values (±SD) of serum iron level of Group I and Group II were 69.06±18.11µg/dl & 15.61±9.12µg/dl respectively. Mean values (±SD) of serum iron significantly lower in study group (Group II) in comparison with control group (Group I). The mean (±SD) of serum zinc level of Group I and Group II were 75.48±14.26µg/dl & 33.27±12.94µg/dl respectively. Mean value (±SD) of serum zinc levels were significantly lower in study group (Group II) in comparison with control group (Group I). Serum zinc level was positively correlated with serum iron and that was statistically significant. The deficiency of iron does not occur alone; rather it is typically associated and developed with hypozincemia. The study suggests on supplementing iron along with zinc to correct the deficiency especially in adolescent girls when their metabolic demand is high.