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1.
Sci Total Environ ; 858(Pt 2): 159908, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36336058

RESUMO

Natural organic matter (NOM), as a ubiquitous component in aqueous environments, has raised continuous scientific concerns due to its role as an organic precursor to disinfection by-products (DBPs) in the subsequent chlorination process. Selective oxidants, including ozone (O3), chlorine dioxide (ClO2), permanganate (Mn(VII)), and ferrate (Fe(VI)) are widely used in the preoxidation stage in drinking water treatment. The selective reactivity of those oxidants toward NOM is expected to alternate NOM properties and consequently DBP formation in postchlorination. Despite extensive studies on the interactions of NOM with selective oxidants, there is currently a lack of an overview of this area. To fill this gap, this study presents the current knowledge of the modification of NOM properties by selective oxidants and its impact on DBP formation in postchlorination. The NOM property changes in three aspects, including bulk property (e.g., total organic carbon, ultraviolet absorbance), fractional constituent (e.g., molecular size, hydrophilicity/hydrophobicity), and elemental composition (e.g., functional group) by the four selective oxidants (i.e., O3, ClO2, Mn(VII), and Fe(VI)) were discussed. Thereafter, the impacts of alteration of NOM properties by those selective oxidants on DBP formation in the subsequent chlorination were summarized, wherein the key influencing factors were discussed. Finally, the future perspectives in this area were forwarded, which highlighted the significance of process optimization, the attention to the less studied but more toxic DBPs, and the need for the identification of unknown DBPs. This review presented a state-of-the-art knowledge pool of the fate of NOM in oxidation and chlorination processes, promoted our understanding of the relationship between NOM properties and DBP formation, and identified further research needs in this area.


Assuntos
Desinfetantes , Água Potável , Poluentes Químicos da Água , Purificação da Água , Oxidantes , Desinfetantes/análise , Poluentes Químicos da Água/análise , Desinfecção , Halogenação , Estresse Oxidativo , Cloro
2.
Bioresour Technol ; 367: 128310, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36370946

RESUMO

Porous carbons are excellent sorbents for removing organic pollutants. Green conversion of biowaste into advanced porous carbons is crucial for industrialized production and practical applications, which, however, have rarely been investigated. This study develops a coassisted carbonization method for the preparation of porous carbons with the environmentally friendly agents HCOOK and (HCOO)2Ca for the first time. The bamboo waste-derived hydrochar was transformed into oxygen-doped porous carbons, which displayed a large surface area and pore volume, abundant oxygen content, graphene structure and many surface functional groups. These properties contributed to the extremely high sorption of large quantities of diethyl phthalate, which reached 761 mg g-1. Surface adsorption, including pore filling, hydrogen bonding, and π-π stacking, rather than partitioning, was the main sorption process. Therefore, this study provides a sustainable and promising route for the preparation of porous carbons that can be applied in the efficient removal of organic pollutants.


Assuntos
Poluentes Ambientais , Oxigênio , Porosidade , Carbono/química , Adsorção , Água/química
3.
J Environ Manage ; 325(Pt A): 116470, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36244283

RESUMO

Reservoir operation strategies with low cost and high efficiency have been proposed to control algal blooms. However, the key hydrodynamic principle for performing reservoir operation strategies is still unknown, posing an obstacle to practical applications. To address this challenge, we proposed short-term emergency reservoir operation strategies (EROSs), established a three-dimensional (3D) eutrophication model of the Zipingpu Reservoir, and designed six 14-day reservoir operation cases to explore the mechanism of EROSs in controlling algal blooms. Large outflows with rapid water exchange should be adopted early in EROSs to control algal blooms in the reservoir. Small variations in the surface water temperature or the mixed layer depth/euphotic layer depth (Zmix/Zeu) ratio were found for different EROSs, indicating that these variations might not have been responsible for the differences in the algal blooms in the reservoir. The EROSs induced high surface flow velocity (Vs) and depth-averaged velocity (Vd) values in the reservoir, thereby controlling algal blooms by inhibiting algal growth and disrupting algal accumulation in the upper water layers. The flow of Vs against the direction of the water intake was detected during the execution of the EROSs, suggesting that increasing Vs might enhance water retention in the reservoir. Increasing Vd not only promoted water exchange to disrupt algal accumulation but also enhanced Vs to inhibit algal growth. Moreover, Vd demonstrated a strong linear relationship with the inhibition ratio of algal blooms. These results demonstrate that Vd is the key hydrodynamic indicator for performing EROSs and that accelerating Vd to exceed 0.039 m s-1 in the near-dam region can control algal blooms. Overall, in this study, we develop a novel EROS and elucidate corresponding principles for the use of EROSs to control algal blooms in reservoirs.


Assuntos
Eutrofização , Hidrodinâmica , Água , China , Monitoramento Ambiental/métodos
4.
Sci Total Environ ; 858(Pt 2): 159914, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36343800

RESUMO

This study introduced a flow electrode microbial desalination cell (FE-MDC), which used activated carbon (AC) particles and carbon nanotubes (CNTs) as the electrode to promote electron harvesting. The recovered electricity energy (0.371 KWh/m3) and columbic efficiency (66.7 %) of the FE-MDC were over 2 times higher than those of the conventional MDC without the flow electrode. Consequently, the salt and COD removal efficiencies were enhanced to 77.8 % and 91.2 %, respectively. Electrochemical analysis implied that the charge transfer resistance of the system was reduced by the flow electrode. Electron accumulation and charging-discharging experiments proved that the flow electrode could accumulate electrons and transfer the electrons to the fixed anode. Bacterial community analysis indicated that the bacterial activity was improved by the flow electrode. The content of the exoelectrogen Pseudomonas increased from 5.0 % to 14.7 %, and Hydrogenophaga improved from 1.4 % to 5.9 %. Finally, a continuous operation mode of the FE-MDC was established, and the flow electrode slurry was returned to the anodic chamber for recirculated utilization. The voltage output, COD removal, and salt removal during the operation mode reached 610 mV, 78.8 %, and 76.1 %, respectively. This study proved that the flow electrode is a promising way to promote the practical application of MDC technology.


Assuntos
Fontes de Energia Bioelétrica , Nanotubos de Carbono , Purificação da Água , Água , Eletrodos , Águas Residuárias , Cloreto de Sódio
5.
Food Chem ; 405(Pt B): 134963, 2023 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-36413846

RESUMO

Various types of fluorescent nanoparticles have been proposed for the detection of veterinary drug residues in food. However, structure-induced fluorescence nanoparticles with biodegradability and the capacity to conjugate with molecular recognition elements are lacking. Here, a biodegradable tryptophan-phenylalanine dipeptide-based nanomaterial was assembled and modified with a sulfadimethoxine aptamer (TPNPs@aptamer). Then, a novel and efficient fluorescence sensing strategy, based on TPNPs@aptamer and BHQ1-labeled single-stranded DNA (BHQ1@cDNA), was developed for sulfadimethoxine determination. Under optimal conditions, the fluorescence was linear in the range of 0-200 ng/mL sulfadimethoxine with a detection limit of 1.47 ng/mL (S/N = 3). Satisfactory recoveries of standard additions were found between 92.88 % and 114.15 % for water and milk samples with a relative standard deviation less than 5.0 %, suggesting that the proposed fluorescence sensing strategy can be applied reliably in sulfadimethoxine analysis of liquid foods.


Assuntos
Dipeptídeos , Nanopartículas , Fluorescência , Sulfadimetoxina , Oligonucleotídeos
6.
Medicine (Baltimore) ; 101(47): e31523, 2022 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-36451486

RESUMO

To analyze the change trend of life expectancy, the change trend of premature death due to 4 major chronic diseases, and its impact on the life expectancy of Wuhai residents from 2015 to 2020, and to provide evidence for the prevention and control of chronic diseases in this area. The data on population death comes from the Wuhai City Residents' Causes of Death Network Reporting System and the total population is calculated using statistics from Wuhai City's permanent population management, from 2015 to 2020. Premature mortality from the 4 main chronic illnesses was calculated using the abridged life table approach. The impact of premature death from chronic diseases on life expectancy was analyzed using the Arriaga method. The increasing trend of life expectancy of Wuhai citizens was not statistically significant from 2015 to 2020 (t = 2.570, P = .062). Each year, men had a lower life expectancy than women (P < .05). From 2015 to 2020, the downward trend of premature deaths caused by the 4 major non-communicable diseases in Wuhai City was statistically significant (EAPC = -7.74%, P = .041). Premature death from cancer and chronic respiratory disorders decreased, both of which were statistically significant (EAPC < 0, P < .05). The decline in premature mortality from cancer, cardiovascular and cerebrovascular disorders, and chronic respiratory system diseases has contributed to increased life expectancy. Diabetes's rise in premature mortality made a possible "negative contribution" to life expectancy (-0.036 years, -1.79%). From 2015 to 2020, the decreasing trend of the overall premature mortality caused by the 4 major non-communicable diseases in Wuhai was statistically significant, and the life expectancy of females was higher than that of males. We should concentrate on the prevention and control of major chronic illnesses in males, as well as the influence of changes in diabetes-related early mortality on life expectancy.


Assuntos
Mortalidade Prematura , Doenças não Transmissíveis , Masculino , Feminino , Humanos , Expectativa de Vida , Doença Crônica , China/epidemiologia
7.
Mitochondrial DNA B Resour ; 7(11): 2002-2005, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36451966

RESUMO

Cyprinid fish Barilius barila found in the Irrawaddy water system is a valuable fishery resource and has been listed as Least Concern by the IUCN. This study determined the complete mitochondrial genome of B. barila from Yunnan, China, for the first time. Circular molecule of B. barila mitogenome was sequenced to be 16,560 bp in length, with the typical gene structure of 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and two noncoding areas (control region and the origin of L-strand replication). Overall nucleotides composition appeared to be 27.5% A, 24.8% T, 19.2% G, and 28.6% C, with a slight AT (52.3%) bias. The topology of the phylogenetic tree showed that B. barila was well grouped with Opsarius caudiocellatus, and clustered together with the genus Opsarius instead of Barilius, revealing that it was more reasonable for Barilius barila to belong to Opsarius rather than Barilius.

8.
Front Genet ; 13: 1037190, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36452155

RESUMO

Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition that requires total hip arthroplasty in most late-stage cases. However, mechanisms underlying the development of ONFH remain unknown, and the therapeutic strategies remain limited. Growth factors play a crucial role in different physiological processes, including cell proliferation, invasion, metabolism, apoptosis, and stem cell differentiation. Recent studies have reported that polymorphisms of growth factor-related genes are involved in the pathogenesis of ONFH. Tissue and genetic engineering are attractive strategies for treating early-stage ONFH. In this review, we summarized dysregulated growth factor-related genes and their role in the occurrence and development of ONFH. In addition, we discussed their potential clinical applications in tissue and genetic engineering for the treatment of ONFH.

9.
Food Chem ; 406: 135081, 2022 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-36463602

RESUMO

Olaquindox residues in food from its illegal use has received great attention. Here, an immunoassay strategy integrating an upconversion nanoparticle (UCNP)-based immunochromatographic strip with a fluorescence reader was proposed for the highly selective and sensitive detection of olaquindox. Polyacrylic acid-functionalized UCNPs were synthesized using a simple ligand exchange process and combined with an olaquindox polyclonal antibody to form a fluorescent probe. This approach achieved a sensitive response and specific recognition of olaquindox. A convenient upconversion fluorescence reader was introduced to implement accurate and sensitive quantitative analysis of olaquindox based on the fluorescence intensity of control and test lines on a strip. Under optimal conditions, the method demonstrated a favorable linear range (0-50 ng/mL) and sensitive detection (1.42 ng/mL, S/N = 3). This method was applied successfully to determine olaquindox in fish muscle and water samples, and results were consistent with an HPLC approach, and considered a promising strategy for monitoring olaquindox residuals.

10.
Adv Mater ; : e2206933, 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-36468617

RESUMO

Developing scalable electrical stimulating platforms for cell and tissue engineering applications is limited by external power source dependency, wetting resistance, microscale size requirements, and suitable flexibility. Here, we developed a versatile and scalable platform that enables tunable electrical stimulation for biological applications by harnessing the giant magnetoelastic effect in soft systems to convert gentle air pressure (100 - 400 kPa) and yield current values of up to 10.5 mA and 9.5 mV. The platform is shown to be easily manufactured and scaled up for integration in multi-well magnetoelastic plates via three-dimensional (3D) printing. We demonstrated that the electrical stimulation generated by this platform enhanced the conversion of fibroblasts into neurons up to 2-fold (104%) and subsequent neuronal maturation up to 3-fold (251%). This easily configurable electrical stimulation device has broad applications in high throughput organ-on-a-chip systems and paves the way for future development of neural engineering, including cellular therapy via implantable self-powered electrical stimulation devices. This article is protected by copyright. All rights reserved.

11.
Front Endocrinol (Lausanne) ; 13: 1054358, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36465636

RESUMO

Simple summary: Studies have shown that about 30% of kidney cancer patients will have metastasis, and lymph node metastasis (LNM) may be related to a poor prognosis. Our retrospective study aims to provide a reliable machine learning-based model to predict the occurrence of LNM in kidney cancer. We screened the pathological grade, liver metastasis, M staging, primary site, T staging, and tumor size from the training group (n=39016) formed by the SEER database and the validation group (n=771) formed by the medical center. Independent predictors of LNM in cancer patients. Using six different algorithms to build a prediction model, it is found that the prediction performance of the XGB model in the training group and the validation group is significantly better than any other machine learning model. The results show that prediction tools based on machine learning can accurately predict the probability of LNM in patients with kidney cancer and have satisfactory clinical application prospects. Background: Lymph node metastasis (LNM) is associated with the prognosis of patients with kidney cancer. This study aimed to provide reliable machine learning-based (ML-based) models to predict the probability of LNM in kidney cancer. Methods: Data on patients diagnosed with kidney cancer were extracted from the Surveillance, Epidemiology and Outcomes (SEER) database from 2010 to 2017, and variables were filtered by least absolute shrinkage and selection operator (LASSO), univariate and multivariate logistic regression analyses. Statistically significant risk factors were used to build predictive models. We used 10-fold cross-validation in the validation of the model. The area under the receiver operating characteristic curve (AUC) was used to assess the performance of the model. Correlation heat maps were used to investigate the correlation of features using permutation analysis to assess the importance of predictors. Probability density functions (PDFs) and clinical utility curves (CUCs) were used to determine clinical utility thresholds. Results: The training cohort of this study included 39,016 patients, and the validation cohort included 771 patients. In the two cohorts, 2544 (6.5%) and 66 (8.1%) patients had LNM, respectively. Pathological grade, liver metastasis, M stage, primary site, T stage, and tumor size were independent predictive factors of LNM. In both model validation, the XGB model significantly outperformed any of the machine learning models with an AUC value of 0.916.A web calculator (https://share.streamlit.io/liuwencai4/renal_lnm/main/renal_lnm.py) were built based on the XGB model. Based on the PDF and CUC, we suggested 54.6% as a threshold probability for guiding the diagnosis of LNM, which could distinguish about 89% of LNM patients. Conclusions: The predictive tool based on machine learning can precisely indicate the probability of LNM in kidney cancer patients and has a satisfying application prospect in clinical practice.


Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Neoplasias Hepáticas , Humanos , Carcinoma de Células Renais/diagnóstico , Metástase Linfática , Estudos Retrospectivos , Neoplasias Renais/diagnóstico , Aprendizado de Máquina , Neoplasias Hepáticas/diagnóstico
12.
Arch Med Sci ; 18(6): 1525-1534, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36457979

RESUMO

Introduction: The role of low-dose aspirin combined with low-molecular-weight heparin (LMWH) in the treatment of preeclampsia (PE) remains unclear. We aimed to assess the efficacy and safety of low-dose aspirin combined with LMWH in PE treatment, to provide evidence for clinical PE management. Material and methods: We searched PubMed and other databases for randomized controlled trials (RCTs) on the effects and safety of low-dose aspirin and LMWH in the treatment of PE up to January 31, 2021. Two researchers strictly followed the inclusion and exclusion criteria to independently conduct the literature screening, data extraction and quality evaluation. We used RevMan 5.3 statistical software for synthesized analysis. Results: A total of 8 RCTs involving 861 patients were included. The synthesized outcome indicated that the differences in systolic blood pressure (MD = -10.61, 95% CI: -13.19 - -8.02), diastolic blood pressure (MD = -9.24, 95% CI: -14.49- -4.00), 24-hour urinary protein (MD = -2.24, 95% CI: -3.97- -0.50), prothrombin time (MD = 1.42, 95% CI: 0.53-2.32), activated partial thromboplastin time (MD = 2.91, 95% CI: 2.06-3.75), FIB (MD = -1.24, 95% CI: -1.32- -1.15), and adverse perinatal outcomes (MD = 0.41, 95% CI: 0.20-0.85) between the two groups were statistically significant (all p < 0.05), while the difference in the adverse reactions of pregnant women (MD = 0.44, 95% CI: 0.18-1.10) between the two groups was not statistically significant (p = 0.08). No publication bias was detected in all the synthesized outcomes (all p > 0.05). Conclusions: Low-dose aspirin combined with LMWH treatment of PE may be advantageous to improve blood pressure, 24-hour proteinuria and coagulation function, and it may reduce the adverse reactions in pregnant women without increasing adverse perinatal outcomes.

13.
Nat Commun ; 13(1): 7489, 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-36470882

RESUMO

Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are both types of lupus, yet the characteristics, and differences between them are not fully understood. Here we show single-cell RNA sequencing data of cutaneous lesions from DLE and SLE patients and skin tissues from healthy controls (HCs). We find significantly higher proportions of T cells, B cells and NK cells in DLE than in SLE. Expanded CCL20+ keratinocyte, CXCL1+ fibroblast, ISGhiCD4/CD8 T cell, ISGhi plasma cell, pDC, and NK subclusters are identified in DLE and SLE compared to HC. In addition, we observe higher cell communication scores between cell types such as fibroblasts and macrophage/dendritic cells in cutaneous lesions of DLE and SLE compared to HC. In summary, we clarify the heterogeneous characteristics in cutaneous lesions between DLE and SLE, and discover some specific cell subtypes and ligand-receptor pairs that indicate possible therapeutic targets of lupus erythematosus.

14.
Food Res Int ; 162(Pt B): 112040, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36461311

RESUMO

Human listeriosis outbreaks are often associated with consumption of contaminated food, especially meat products. To better understand meat contamination of L. monocytogenes, whole genome sequencing(WGS) was performed on all detected isolates to investigate genetic relationships between retail markets and slaughterhouses. 110 and 13 isolates were isolated from 1914 food samples and 67 food and environmental samples, respectively. IIa (51/123,41.5%) and IIc (7/123,5.7%) were detected as the dominant serogroups of 123 L. monocytogenes isolates.Most isolates were penicillin-resistant (22/123,17.9%) in the phenotypic test, and all isolates were also found to be susceptible to ampicillin, meropenem, and vancomycin. All of them harbored virulence-associated genes and premature stop codons (PMSCs) in inlA genes were occurred in 35 strains. 22 multilocus sequence types and 19 clonal complexes were identified with ST9 being most common. This study also showed the prevalence and uniqueness of strains from Jilin, China compared with worldwide epidemic international strains. The findings of this study will contribute to the epidemiological understanding of transmission of L. monocytogenes from production and circulation in the region of northern China.


Assuntos
Listeria monocytogenes , Humanos , Listeria monocytogenes/genética , Virulência/genética , Carne , Resistência Microbiana a Medicamentos , Variação Genética
15.
RSC Adv ; 12(45): 29543-29553, 2022 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-36320722

RESUMO

In this study, the compositions of oily sludge and sludge containing polymers were analyzed. Sludge was separated preliminarily by conditioning centrifugal technology, whereby the temperature of the centrifugal process and the amount of oil/water separating agent were optimized. Thermal decomposition technology was combined in order to achieve the efficient treatment of sludge. The results showed that the compositions of oily sludge and sludge containing polymers were complex. Therefore, they could not meet the requirements of environmental protection only by conditioning centrifugal technology. After optimization, the best conditioning centrifugal temperature was 70 °C and the content of the oil/water separating agent was 2%. The high efficiency treatment of oily sludge and sludge containing polymers could be realized by combining conditioning centrifugal technology with the thermal decomposition technology. It is found that the sludge could meet the requirements of environmental protection after this combined treatment. This technology has strong adaptability to different types of oilfield sludge. This work is of great significance for the efficient treatment of oily sludge and sludge containing polymers and for environmental protection.

16.
Front Neurol ; 13: 996199, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36341093

RESUMO

Objective: This study aims to examine the value of two-dimensional (2D) ultrasound and two-dimensional shear wave elastography (2D-SWE) in evaluating femoral nerve (FN) and saphenous nerve (SN) neuropathy in patients with type 2 diabetes mellitus (T2DM). Materials and methods: According to the diabetic peripheral neuropathy (DPN) diagnostic criteria, 60 patients with T2DM were enrolled and divided into 35 T2DM patients without DPN (non-DPN group) and 25 T2DM patients with DPN (DPN group). The control group consisted of another 15 healthy volunteers. The width, thickness, cross-sectional area (CSA), and perimeter of the FN and SN in the lower extremities were measured with 2D ultrasound. The average shear wave velocity (SWV) of the FN and SN was measured by 2D-SWE. Parameters of the left and right lower extremities were compared in each group, and the above parameters were compared among groups. The correlations between ultrasonographic and laboratory parameters were evaluated, and the independent influencing factors of SWV of the FN and SN were analyzed. Results: The width, thickness, CSA, perimeter, and SWV of FN and SN in the DPN group were greater than those in the non-DPN groups and control group (P < 0.05). The width, thickness, CSA, perimeter, and SWV of the FN and SN in the non-DPN group were greater than those in the control group (P < 0.05). The CSA of FN was positively correlated with FPG, HbA1c, and TG (r = 0.34-0.69, P < 0.01). The perimeter of FN was positively correlated with FPG, HbA1c, and TG (r = 0.37-0.68, P < 0.01). The perimeter of the FN was negatively correlated with IgF-1 (r = -0.31, P < 0.05). The CSA of the SN was positively correlated with FPG and TG (r = 0.26-0.42, P < 0.05). The perimeter of the SN was positively correlated with FPG and TG (r = 0.37-0.39, P < 0.01). The SWV of FN and SN were positively correlated with FPG and TG (r = 0.35-0.57, P < 0.01; r = 0.43-0.49, P < 0.01). FPG and TG were independent influencing factors of the SWV of the FN and SN (P < 0.05). Conclusion: 2D ultrasound and 2D-SWE could be used to non-invasively, objectively, and accurately evaluate the abnormal changes of the FN and SN in patients with T2DM. It has important clinical significance for the early diagnosis of DPN and the curative effect evaluation.

17.
18.
Nanomicro Lett ; 14(1): 218, 2022 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-36352159

RESUMO

Aqueous zinc-ion batteries (AZIBs) are one of the promising energy storage systems, which consist of electrode materials, electrolyte, and separator. The first two have been significantly received ample development, while the prominent role of the separators in manipulating the stability of the electrode has not attracted sufficient attention. In this work, a separator (UiO-66-GF) modified by Zr-based metal organic framework for robust AZIBs is proposed. UiO-66-GF effectively enhances the transport ability of charge carriers and demonstrates preferential orientation of (002) crystal plane, which is favorable for corrosion resistance and dendrite-free zinc deposition. Consequently, Zn|UiO-66-GF-2.2|Zn cells exhibit highly reversible plating/stripping behavior with long cycle life over 1650 h at 2.0 mA cm-2, and Zn|UiO-66-GF-2.2|MnO2 cells show excellent long-term stability with capacity retention of 85% after 1000 cycles. The reasonable design and application of multifunctional metal organic frameworks modified separators provide useful guidance for constructing durable AZIBs.

19.
Adv Mater ; : e2209390, 2022 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-36444512

RESUMO

Achieving net-zero emissions requires low-cost and reliable energy storage devices that are essential to deploy renewables. Alkaline zinc-based flow batteries such as alkaline zinc-iron (or nickel) flow batteries are well-suited for energy storage because of their high safety, high efficiency, and low cost. Nevertheless, their energy density is limited by the low solubility of ferro/ferricyanide and the limited areal capacity of sintered nickel electrodes. Here, combining the electrochemical reaction with the chemical reaction of ferro/ferricyanide couple in a home-made nickel electrode, we report an alkaline zinc-iron/nickel hybrid flow battery with a high energy density of 208.9 Wh L-1 and an energy efficiency of 84.7% at a high current density of 80 mA cm-2 . The reversible chemical reactions between dual couples are proven to stabilize the nickel electrode by promoting the activation of the nickel electrode and further preventing the formation of γ-NiOOH. A kW-scale stack is demonstrated by the integration of ferro/ferricyanide couple with nickel electrode, delivering a coulombic efficiency of 98% and an energy efficiency of 89% at 40 mA cm-2 . This work demonstrates a promising pathway for constructing and upscaling flow batteries with high energy density and low cost. This article is protected by copyright. All rights reserved.

20.
Arch Pathol Lab Med ; 2022 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-36445697

RESUMO

CONTEXT.­: Glioma is the most common primary brain tumor in adults. The diagnosis and grading of different pathological subtypes of glioma is essential in treatment planning and prognosis. OBJECTIVE.­: To propose a deep learning-based approach for the automated classification of glioma histopathology images. Two classification methods, the ensemble method based on 2 binary classifiers and the multiclass method using a single multiclass classifier, were implemented to classify glioma images into astrocytoma, oligodendroglioma, and glioblastoma, according to the 5th edition of the World Health Organization classification of central nervous system tumors, published in 2021. DESIGN.­: We tested 2 different deep neural network architectures (VGG19 and ResNet50) and extensively validated the proposed approach based on The Cancer Genome Atlas data set (n = 700). We also studied the effects of stain normalization and data augmentation on the glioma classification task. RESULTS.­: With the binary classifiers, our model could distinguish astrocytoma and oligodendroglioma (combined) from glioblastoma with an accuracy of 0.917 (area under the curve [AUC] = 0.976) and astrocytoma from oligodendroglioma (accuracy = 0.821, AUC score = 0.865). The multiclass method (accuracy = 0.861, AUC score = 0.961) outperformed the ensemble method (accuracy = 0.847, AUC = 0.933) with the best performance displayed by the ResNet50 architecture. CONCLUSIONS.­: With the high performance of our model (>80%), the proposed method can assist pathologists and physicians to support examination and differential diagnosis of glioma histopathology images, with the aim to expedite personalized medical care.

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