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1.
Front Biosci (Elite Ed) ; 12: 113-125, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31585873

RESUMO

We investigated coronary heart disease (CHD) and cardiovascular disease (CVD) event rates in a diverse population with a coronary artery calcium score (CACS) of 0 and the role of CACS in the detection of subclinical noncalcified atherosclerotic plaque. A total of 15,884 participants in five studies were included in this meta-analysis. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated. The results showed that CHD incidence significantly increased with increased CACS (HR=0.05, 95% CI 0.03-0.06, Z=5.82, P=0.002). The CHD rate was low and further increased with CACS of 101-300. With CACS >300, the CHD rate was highest. Similarly, CVD rate was low with CACS of 0, increased with CACS of 1-100 (HR=0.03, 95% CI 0.01-0.06, Z=1.66, P=0.096), and further increased with CACS of 101-300. With CACS >300, the CVD rate was highest. Clinical evidence indicated that the higher the CACS, the higher the CHD and CVD rates, while the CVD rate does not always decreased compared with CHD rate with the same CACS, especially with CACS of 0.

2.
J Cardiothorac Surg ; 14(1): 176, 2019 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-31639022

RESUMO

OBJECTIVE: To evaluate the health-related quality of life (HRQoL) of adult patients who underwent transthoracic device closure of ventricular septal defect (VSD). METHODS: During the perioperative and postoperative period, a standard scale involving eight dimensions was used to analyze the HRQoL of 85 adult patients who underwent thoracic device closure of VSD and 80 healthy adults located locally were randomly selected as the control group in our center. RESULTS: A total of 80 patients' and 80 healthy adults' questionnaires were received with complete feedback. Out of all of the items that were investigated, postoperative patients experienced better feelings in some dimensions than the control group. Postoperative feedback was also better than preoperative feedback in some dimensions. In the comparison of the subgroups of these patients, the scores of the elderly were lower than those of the young in most dimensions. Males had more positive feedback in two aspects ("role-physical" (p = 0.01) and "vitality" (p = 0.003)), whereas unmarried people seemed to have poor emotional responses ("role-emotional" (p < 0.01) and "vitality" (p = 0.023)). There was no significant difference in any dimensions except "social functioning" (p < 0.01) between people with different levels of education. CONCLUSIONS: Most of the adult patients who underwent thoracic closure of VSD felt that they could lead a normal life. They seemed to have reasonably normal psychosocial responses compared to healthy controls. Many patients even though their HRQoL was better than healthy individuals.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31650832

RESUMO

Up to now, ferroptotic therapeutic strategies remain simplex, though ferroptosis has aroused extensive interest owing to its escape from the biocarriers of conventional therapeutic modalities. Herein, we construct a photothermal (PT)- and autophagy-enhanced ferroptotic therapeutic modality based on MnO2@HMCu2-xS nanocomposites (HMCM) for efficient tumor ablation. The HMCM possess PT-enhanced glutathione (GSH) depletion capability, thereby inducing PT-enhanced ferroptosis via the reinforced inactivation of glutathione peroxidase 4 (GPX4). Thereafter, the GSH-responsed Mn2+ release could generate reactive oxygen species (ROS) by Fenton-like reaction to reinforce the intracellular oxidative stress for the lipid hydroperoxides (LPO) accumulation in ferroptosis. Additionally, an autophagy promotor rapamycin (Rapa) was loaded into HMCM for sensitizing cells to ferroptosis, due to the indispensable role of autophagy in the ferroptosis process. The in vitro and in vivo data demonstrated the HMCM exhibited superior anticancer effect in human breast cancer models, and the combination therapeutic system afford the next generation of ferroptotic therapy for combatting malignant tumor.

4.
Nano Lett ; 2019 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-31573819

RESUMO

We present experimental results confirming extreme quantum confinement in GaN/AlxGa1-xN (x = 0.65 and 1.0) nanowire and planar heterostructures, where the GaN layer thickness is of the order of a monolayer. The results were obtained from temperature- and excitation-dependent and time-resolved photoluminescence measurements. In the GaN/AlN nanowire heterostructure array sample, the measured emission peak at 300 K is ∼5.18-5.28 eV. This is in excellent agreement with the calculated optical gap of 5.23 eV and 160-260 meV below the calculated electronic gap of 5.44 eV, suggesting that the observed emission is excitonic in nature with an exciton binding energy of ∼160-260 meV. Similarly, in the monolayer GaN/Al0.65Ga0.35N planar heterostructure, the measured emission peak at 300 K is 4.785 eV and in good agreement with the calculated optical gap of 4.68 eV and 95 meV below the calculated electronic gap of 4.88 eV. The estimated exciton binding energy is 95 meV and in close agreement with our theoretical calculations. Excitation-dependent and time-resolved photoluminescence data support the presence of excitonic transitions. Our results indicate that deep-ultraviolet excitonic light sources and microcavity devices can be realized with heterostructures incorporating monolayer-thick GaN.

5.
J Palliat Med ; 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31573417

RESUMO

Background: Dyspnea is one of the most common symptoms in patients with advanced disease and terminal illness, associated with poorer quality of life. The efficacy of fan therapy to palliate dyspnea is inconsistent and unclear. Objective: The aim of this meta-analysis was to evaluate the efficacy of fan therapy for the relief of dyspnea in adults with advanced disease and terminal illness. Design: The CENTRAL, MEDLINE, EMBASE, CINAHL, and PsycINFO were searched to retrieve all randomized controlled trials examining the benefits of fan therapy for the relief of dyspnea in patients at the advanced stages of illness. Risk of bias was assessed according to the Cochrane Collaboration standard scheme. Results: Five studies involving 198 adults were identified. Fan therapy was associated with a significant relief of breathlessness intensity immediately after intervention (mean differences [MDs], -1.01; 95% confidence interval [CI], -1.57 to -0.45; p < 0.001) and 10 minutes after intervention (MDs, -0.90; 95% CI, -1.53 to -0.27; p = 0.005). Long-term application of fan therapy for at least one month was not related to changes of dyspnea severity (MDs, 0.10; 95% CI, -1.14 to 1.35; p = 0.870). However, significant heterogeneity and low quality of the included trials limit applicability of the results in general practice. No difference was found in activity performance, respiratory rate and SpO2, changes in other symptom intensities, and adverse events. Conclusion: Current trials provided low-quality evidence for a significant short-term effect after fan therapy in the relief of dyspnea and no beneficial effect in the long-term application in adults with advanced disease and terminal illness.

6.
Plant Sci ; 289: 110282, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31623771

RESUMO

The metabolic profile of rice (Oryza sativa) during germination under low temperature (LT) has not been reported. In this study, the rice varieties 02428 (japonica) and YZX (indica) were subjected to experiments consisting of treatments including LT, normal temperature (NT) and a transition from LT to NT, and tissues were sampled at different time points during germination. A total of 730 metabolites were detected by a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based widely targeted metabolomics method. On the basis of the screening criteria of increased contents under LT and decreased contents under NT, we identified 35 different metabolites that responded to LT stress among the 730 metabolites. Furthermore, the content differences of the 35 metabolites were compared when the samples were transferred from LT to NT. According to a fold change <0.5 or a variable importance in projection (VIP) score>1 at the transition point, 7 out of the 35 metabolites responded significantly to LT stress and were defined as key metabolites. A partial least squares (PLS) regression model of seven key metabolites with seedling length (SL), seedling area (SSA), and seedling volume (SV) was constructed, and the fitting effect was good. These seven key metabolites participate in the biosynthesis of amino acids and phenylpropanoids and in the metabolism of glutathione and inositol phosphate. This study laid a foundation for an improved understanding of the LT-germination mechanism of rice seeds.

7.
Chem Commun (Camb) ; 55(84): 12615-12618, 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31580369

RESUMO

A metal-free cascade reaction was developed for the synthesis of indolo[1,2-a]quinoline derivatives from arylsulfonyl hydrazides and 1-(2-(arylethynyl)phenyl)indoles in the presence of TBAI/TBHP. Impressively, these products exhibit excellent fluorescence properties, which is promising for cell imaging.

8.
Zhongguo Zhong Yao Za Zhi ; 44(14): 2987-2995, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31602844

RESUMO

The study aims to investigate spatial distribution pattern and age structure of wild Angelica sinensis in Gansu province.Ten plots each with an area of 100 m2 were set and the spatial coordinates of all wild A. sinensis individuals were measured within each plot. Based on plant individual mapping data,we explored the spatial distribution pattern and its differences between different life history stages of wild A. sinensis in Gansu province by using nearest neighbor distance statistics. Correlation analysis were carried out to explore the relationship between spatial aggregation degree and topographic factors. We also distinguished individuals to three life history stages( i.e. seedlings,adults and boltings) and then test the differences among/between them using nonparametric test.(1)We found that the dominant spatial distribution pattern of wild A. sinensis population in Gansu was aggregated distribution. There was no significant correlation between spatial aggregation degree of wild A. sinensis and altitude,slope and aspect. There was no significant difference between the average distance from seedlings to their nearest bolting individuals; the average distance from adult individuals to their nearest seedlings was significantly larger than the average distance from adult individuals to their nearest adult individuals; and the average distance from bolting individuals to their nearest adult individuals was significantly smaller than the average distance from bolting individuals to their nearest bolting individuals.(2)The age structure was showed as a declining population,characterized by less seedlings and bolting individuals,while more adult individuals within population. The population characteristics of wild A. sinensis,characterized by aggregated distribution pattern and senescent type of age structure,are disadvantage to its population development. The factors,such as habitat specialization,human activities and intraspecific competition,which shapes the current population characteristics,may increase the threatened status of wild A. sinensis. We suggest to strengthen the protection of wild A. sinensis.


Assuntos
Angelica sinensis/crescimento & desenvolvimento , Ecossistema , Altitude , China , Conservação dos Recursos Naturais , Plântula , Análise Espacial
10.
Med Sci Monit ; 25: 7391-7395, 2019 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-31576813

RESUMO

BACKGROUND We introduce a minimally invasive technique for the treatment of Raynaud disease - CT-guided percutaneous thoracic sympathetic chain radiofrequency thermocoagulation. MATERIAL AND METHODS Under CT guidance, the radiofrequency needle was punctured from the upper edge of the costotransverse joint to the anterior superior edge of the 4th capitulum costae and the lateral parietal pleura. After sensorial (1.5 mA, 50 Hz) and motorial (1.5 mA, 2Hz) testing to determine that there was no nerve innervation zone with muscle numbness and twitches, radiofrequency coagulation was set at 95°C for 300 s. RESULTS A total of 17 patients were enrolled in the treatment group. All the patients underwent CT-guided percutaneous thoracic sympathetic chain puncture of the needles to the upper edge of the 4th capitulum costae on both sides. The perfusion index (PI) of the fingers began to rise 30 s after radiofrequency thermocoagulation, and the palm temperature (T) began to rise after 90 s. At the end of treatment, PI increased by an average of 4.6-fold, and the T average rose by 3.6°C. Postoperative cold-water stimulation testing could no longer induce Raynaud disease. Follow-up was conducted for 1 to 15 months. Two patients were found to have recurrence at 9 months and 13 months, respectively. CONCLUSIONS CT-guided percutaneous thoracic sympathetic nerve chain radiofrequency coagulation can effectively treat Raynaud disease.

11.
J Cell Physiol ; 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31613009

RESUMO

Acute myelocytic leukemia (AML) is an aggressive malignant tumor and typically fatal without treatment. Identification and development of novel biomarkers could be beneficial for the diagnosis and prognosis of AML patients. Here, we aimed to identify the accurate DNA methylation prognostic signatures for AML patients. The DNA methylation data of AML patients and corresponding clinical information were retrieved from The Cancer Genome Atlas database. CPG sites that correlates closely with the survival of the AML patients were identified and further combined into CPG sites pairs to screen the survival-related pairs. The prognostic signatures were identified by the C-index and forward search algorithms and validated by the verification group. Finally, the functional enrichment analysis was performed on these CPG sites. As a result, a total of 498 CPG sites associated with the overall survival of AML patients was obtained. A prognostic signature composed of 10 CPG sites pairs was obtained and validated. The functional enrichment analysis showed prognostic genes were mainly enriched in tumor protein processing, cell differentiation, blood leukocyte immunity, and platelet growth factor pathways. In summary, we identified two accurate prognostic methylation signatures (NDRG2 and TLR7), which would be served as a novel therapy target for AML.

12.
Aging (Albany NY) ; 11(19): 8664-8680, 2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31606726

RESUMO

Osteoarthritis (OA) is the most common degenerative joint disease and involves the loss of articular cartilage integrity, formation of articular osteophytes, remodeling of subchondral bone, and synovitis. Knockdown of receptor interacting serine/threonine kinase (RIPK) 1 leads to anti-inflammatory and anti-apoptotic effects. However, the involvement of RIPK1 in the pathogenesis of OA is unclear. Here, we evaluated the effect of RIPK1 on chondrocytes and elaborated the underlying molecular mechanism. Knockdown of RIPK1 protected chondrocytes against inflammation and apoptosis induced by interleukin (IL)-1ß in vitro and in vivo. RIPK1 was required for myeloid differentiation primary response 88 (MyD88)- and TIR-domain-containing adapter-inducing interferon b (TRIF)-mediated production of matrix metalloproteinases (MMPs) in OA. Moreover, overexpression of RIPK1 promoted the expression of tumor necrosis factor receptor-associated factor 2 (TRAF2), which blocked the expression and phosphorylation of RIPK1. Upregulation of TRAF2 decreased the expression of TRIF, MyD88, and MMPs in chondrocytes. Furthermore, knockdown of RIPK1 blocked activation of the nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) signaling pathways. In summary, knockdown of RIPK1 alleviated OA in a manner mediated by the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop and activation of the NF-κB and JNK signaling pathways.

13.
Cell Metab ; 30(4): 706-719.e6, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31495688

RESUMO

The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the clinic have failed to effectively treat obesity, predominantly due to a phenomenon referred to as leptin resistance. The mechanisms linking obesity and the associated leptin resistance remain largely unclear. With various mouse models and a leptin neutralizing antibody, we demonstrated that hyperleptinemia is a driving force for metabolic disorders. A partial reduction of plasma leptin levels in the context of obesity restores hypothalamic leptin sensitivity and effectively reduces weight gain and enhances insulin sensitivity. These results highlight that a partial reduction in plasma leptin levels leads to improved leptin sensitivity, while pointing to a new avenue for therapeutic interventions in the treatment of obesity and its associated comorbidities.

14.
Artigo em Inglês | MEDLINE | ID: mdl-31520391

RESUMO

The aim of this study was to compare environmental pollution and ecological states of two different areas of the Songhua River areas: near Harbin City and Tongjiang City, located at a distance of about 500 km downstream. The anthropogenic pollution concentrations of heavy metals (HM) were determined. The results showed that concentrations of eight metals (Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn) in the water were in the range of 0.001-0.588 mg/L for Tongjiang and 0.001-0.508 mg/L for Harbin, while that in sediments were in the range of 0.67-1575.37 mg/kg for Tongjiang and 0.07-5617.13 mg/kg for Harbin, respectively. Bivalves from tested sites exposed to environmental pollution exhibited significantly different physiological states. The latter was assessed using the method of physiological loading, based on measuring the recovery time (Trec) of heart rate (HR) after removal of the load. Trec in mussels from Harbin was recorded in the range of 151 to 234 min, while that from Tongjiang was only 115 min. Cd, Cu, Pb, and Zn in mollusk soft tissues were also determined for Harbin and Tongjiang, respectively. The metal pollution index (MPI) and bioconcentration factor (BCF) in the mollusks were calculated for each metal. BCF in the mussels from the Tongjiang area was lower than that from the Harbin area. Physiological testing, as well as the concentration of HM in water, and sediment, and also the bioaccumulation of HM in tissue showed that the ecological state of the Tongjiang area was better than that of Harbin. Apparently, after more extensive studies, a methodological approach of assessing the ecological state of water areas, based on physiological state testing of aboriginal mollusks, could be used in the monitoring of pollution effects in water bodies and streams.

15.
Ying Yong Sheng Tai Xue Bao ; 30(9): 2949-2954, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31529869

RESUMO

Monthly phytolith-occluded organic carbon (PhytOC) content in living leaves and litterfall of Moso bamboo (Phyllostachys edulis) were measured for a year. The PhytOC sequestration rate in living leaves of different months were compared with that in annual litterfall to determine the optimum sampling time of living leaves for estimating PhytOC sequestration rate of Moso bamboo. The contents of phytoliths and PhytOC in living leaves of Moso bamboos were 23.45-101.07 g·kg-1 and 0.73-1.98 g·kg-1, respectively, with significant difference among different months. The monthly PhytOC sequestration rates of living leaves of Moso bamboo in different months ranged from 0.75 to 7.68 kg·hm-2·a-1. The maximum and minimum rates of the PhytOC sequestration occurred in December and April respectively, with significant difference between them. There was no difference between the PhytOC sequestration rate in living leaves of Moso bamboos in February or December and that of litterfall in the whole year. Therefore, February or December should be the optimal month of sampling living leaves for estimating the PhytOC sequestration rate of Moso bamboo stands.


Assuntos
Sequestro de Carbono , Poaceae/fisiologia , Carbono , Folhas de Planta/fisiologia
16.
Water Res ; 166: 115040, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31505307

RESUMO

Estrogens are a category of non-degradable organic pollutants prevalent in aquatic environments with reported health risks in human and wildlife reproduction. A biotechnological approach is proposed for utilizing fungal laccase-mediated humification reactions (L-MHRs) to remove estrogens from water. Through a reactive radical-mediated C-C, C-O-C, or C-N-C covalent coupling mechanism, multifarious complex polymeric structures are generated having limited solubilities, which significantly reduces their estrogenic activity and ecotoxicity. This review highlights the available literature associated with the self/cross-coupling mechanism of fungal L-MHRs in catalyzing the single-electron oxidation of estrogens and humic acid (HA). Advances in identifying unknown estrogen-HA cross-coupling products using high-resolution mass spectrometry combined with 13C-isotope labeling and 13C NMR may provide key research directions beneficial to aquatic ecological restoration measures.

17.
Free Radic Biol Med ; 145: 175-186, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31541678

RESUMO

The cardiovascular efficacy of glucose-lowering drugs is needed due to the cardiovascular complication in type 2 diabetes mellitus (T2DM). Acarbose is an α-glucosidase inhibitor that suppresses postprandial hyperglycemia, however, the cardiovascular protection of acarbose has still remained controversial. NLRP3 inflammasome activation mediated tight junction disruption, a hallmark event of endothelial barrier dysfunction leading to endothelial hyperpermeability in diabetes. Given the anti-inflammatory property of acarbose, it was investigated that acarbose protected against vascular endothelial barrier dysfunction through inhibiting NLRP3 inflammasome in vascular endothelial cells in T2DM rats. The rat aortic endothelial cells (RAECs) were incubated with high glucose (HG, 30 mM) for 24 h in vitro. It was found that HG significantly induced the formation and activation of NLRP3 inflammasome, which was markedly blocked by acarbose treatment. Furthermore, acarbose blocked the Nox4-dependent superoxide (O2.-) generation, which regulated NLRP3 inflammasome in RAECs. Importantly, we found that acarbose remarkably enhanced the junction protein expression of ZO-1 and VE-Cadherin and consequently abolished vascular hyperpermeability, which was associated with inhibiting NLRP3 inflammasome in RAECs. In vivo, acarbose intervention relieved vascular leakage in the heart of diabetic rats injected with Evans blue dye and the vasodilatory response to acetylcholine, which was accompanied with the restoration of ZO-1, VE-Cadherin, Nox4 and NLRP3 inflammasome in the aortal endothelium of diabetic rats. Taken together, our data indicated that acarbose ameliorated endothelial barrier dysfunction by directly inhibiting NLRP3 inflammasome which was dependent on inhibiting Nox4 oxidase-dependent O2.- production. These properties might carry a potential significance for acarbose in cardiovascular protection in diabetic patients.

18.
Artigo em Inglês | MEDLINE | ID: mdl-31491792

RESUMO

BACKGROUND: The purpose of this study was to compare the opening and closing sounds of three different mechanical mitral valves and to analyze their effects on the quality of life of patients. METHODS: Ninety patients who underwent mechanical mitral valve replacement (MVR) were divided into three groups: those who received Advancing the Standard (ATS), St. Jude Medical (SJM), or Carbomedics (CM) mechanical valves. The sound pressure of the different valves was measured with a microphone. A detailed, self-designed questionnaire with a 1 to 10 analog scale and the 36-item Short Form Health Survey (SF-36) score was used to assess the quality of life of the patients. RESULT: The sound pressure measured by ATS was 64.4 ± 3.1 dB, while that measured by SJM, and CM was 64.5 ± 4.7 and 67.2 ± 5.3 dB, respectively. The overall subjective interference score in the ATS group was the lowest compared with that in the SJM and CM groups (ATS: 1.3 ± 0.9 dB, SJM: 3.9 ± 1.6 dB, CM: 4.1 ± 1.5 dB). Relatives and nonfamily members of the ATS group also had the lowest analog scale scores. Specific questions showed that the ATS valve had the least impact on sleep and daily life (impact on sleep: ATS: 4/30, SJM: 9/30, CM: 11/30, impact on daily life: ATS: 2/30, SJM: 8/30, CM: 8/30). The SF-36 score showed that there were significant differences in social functioning, role-emotional, mental health, and vitality. CONCLUSION: Patients receiving ATS mechanical MVR may be less disturbed by valve noise than those receiving SJM or CM mechanical MVR in a single Chinese cardiac center.

19.
BMJ Open ; 9(9): e031513, 2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31542763

RESUMO

OBJECTIVES: To determine the prevalence of physical violence and threats against health workers and the aftermath in tertiary, secondary and primary care facilities in China. DESIGN: A cross-sectional questionnaire study. SETTING: 5 tertiary hospitals, 8 secondary hospitals and 32 primary care facilities located in both urban and rural areas of Zhejiang Province, China, were chosen as the study sites. PARTICIPANTS: A total of 4862 health workers who have contact with patients completed a survey from July 2016 to July 2017. OUTCOME MEASURES: The prevalence of physical violence, threats and Yi Nao, specific forms of physical violence and their aftermath were measured by a self-designed and verified questionnaire. Multivariable logistic regression models were used to examine the association between perceived organisational encouragement of reporting workplace violence (WPV) and physical violence, threats and Yi Nao after controlling for age, sex, level of facility, professional ranking and type of health worker. RESULTS: Among all respondents, 224 (4.6%) were physically attacked and 848 (17.4%) experienced threats in the past year. Respondents in secondary hospitals were more likely to experience physical violence (AOR=3.29, 95% CI 2.21 to 4.89), threats (AOR=1.61, 95% CI 1.32 to 1.98) and Yi Nao (AOR=2.47, 95% CI 2.10 to 2.91), compared with primary care providers. Lack of organisational policies to report WPV was associated with higher likelihood of physical violence (AOR=3.64, 95% CI 2.57 to 5.18) and threats (AOR=2.21, 95% CI 1.76 to 2.78). Among physical violence cases, only 29.1% reported the attack to police mainly because most felt it useless to do so (58.8%). Only 25.7% were investigated and 72.4% of attackers received no punishment. Of all those attacked or threatened, 59.4% wanted to quit current post and 76.0% were fearful of dealing with urgent or severe cases. CONCLUSIONS: Proper management of the aftermath of violence against health workers is inadequate. Formal guidelines for reporting and managing WPV are urgently needed.

20.
Org Biomol Chem ; 17(36): 8364-8368, 2019 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-31478050

RESUMO

A method for metal-free, 1,3-dibromo-5,5-dimethylhydantoin mediated methyl C(sp3)-H bond azolation of thioanisoles has been developed, affording a facile route for the construction of nitrogen-functionalized thioanisoles, possibly via a nitrogen-centered radical process. This reaction represents an important addition to the limited number of existing methods for the methyl C(sp3)-H bond functionalization of thioanisoles, and may find practical application in the synthesis of nitrogen-alkylated azoles.

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