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1.
Front Oncol ; 12: 940655, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36338691

RESUMO

Purpose: To develop a nomogram based on radiomics signature and deep-learning signature for predicting the axillary lymph node (ALN) metastasis in breast cancer. Methods: A total of 151 patients were assigned to a training cohort (n = 106) and a test cohort (n = 45) in this study. Radiomics features were extracted from DCE-MRI images, and deep-learning features were extracted by VGG-16 algorithm. Seven machine learning models were built using the selected features to evaluate the predictive value of radiomics or deep-learning features for the ALN metastasis in breast cancer. A nomogram was then constructed based on the multivariate logistic regression model incorporating radiomics signature, deep-learning signature, and clinical risk factors. Results: Five radiomics features and two deep-learning features were selected for machine learning model construction. In the test cohort, the AUC was above 0.80 for most of the radiomics models except DecisionTree and ExtraTrees. In addition, the K-nearest neighbor (KNN), XGBoost, and LightGBM models using deep-learning features had AUCs above 0.80 in the test cohort. The nomogram, which incorporated the radiomics signature, deep-learning signature, and MRI-reported LN status, showed good calibration and performance with the AUC of 0.90 (0.85-0.96) in the training cohort and 0.90 (0.80-0.99) in the test cohort. The DCA showed that the nomogram could offer more net benefit than radiomics signature or deep-learning signature. Conclusions: Both radiomics and deep-learning features are diagnostic for predicting ALN metastasis in breast cancer. The nomogram incorporating radiomics and deep-learning signatures can achieve better prediction performance than every signature used alone.

2.
Aesthet Surg J ; 42(5): NP319-NP326, 2022 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-36413200

RESUMO

BACKGROUND: Knowledge of the anatomy of the facial vein is essential for plastic surgery and filler injection. OBJECTIVES: The authors sought to investigate the variation and 3-dimensional (3D) course of the facial vein utilizing computed tomographic angiography. METHODS: The computed tomographic angiography images of 300 facial veins from 150 Asian patients were included in this study. The distance between each anatomical landmark and the facial vein was measured to position the course. The depth of the facial vein beneath the skin and the height of the facial vein above the periosteum were measured at 5 anatomical planes. RESULTS: The facial vein showed a relatively constant course with a frequency of 7.0% variation. The vertical distance between the medial canthus, midpoint of inferior orbital rim, or external canthus and the facial vein was 10.28 ± 2.17 mm, 6.86 ± 2.02 mm, or 48.82 ± 7.26 mm, respectively. The horizontal distance between medial canthus, nasal alar, or oral commissure and the facial vein was 6.04 ± 1.44 mm, 22.34 ± 3.79 mm, or 32.21 ± 4.84 mm, respectively. The distance between the mandibular angle or oral commissure and the facial vein at the inferior of mandible was 24.99 ± 6.23 mm or 53.04 ± 6.56 mm. The depth of the facial vein beneath the skin and the height of the facial vein above the periosteum varied from the plane of the medial canthus to the plane of the mandible. CONCLUSIONS: This study revealed the 3D course of the facial vein with reference to anatomical landmarks. Detailed findings of the facial vein will provide a valuable reference for plastic surgery and filler injection.


Assuntos
Procedimentos Cirúrgicos Reconstrutivos , Cirurgia Plástica , Humanos , Cirurgia Plástica/métodos , Procedimentos Cirúrgicos Reconstrutivos/métodos , Angiografia , Angiografia por Tomografia Computadorizada , Tomografia Computadorizada por Raios X
3.
ACS Appl Mater Interfaces ; 14(46): 52370-52378, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36349689

RESUMO

Millirobots that can be actuated and accurately steered by external magnetic fields, are highly desirable for bioengineering and wearable devices. However, existing designs of millirobots are limited by their specific material composition, hindering their wider application due to a lack of scalability. Here, we present a method for the generation of heterogeneous magnetic millirobots based on magnetic coatings. The coatings, composed of hard-magnetic CrO2 particles dispersed in an adhesive solution, impart magnetic actuation to diverse substrates with planar sheets or 3D structures. Millirobots constructed from the coatings can be readily reprogrammed with intricate magnetization profiles using laser localized heating, enabling reconfigurable shape changes under magnetic actuation. Using this approach, we demonstrate on-demand maneuvering capability of reconfiguring locomotion involving crawling, overturning and rolling with a single millirobot. Various functions, including the ability to catch a fast-moving ball, object transportation, and targeted assembly, have been achieved. This adhesive strategy facilitates the design of millirobots and may open avenues to the creation of complex millirobots for broad applications.

4.
Front Cardiovasc Med ; 9: 1001072, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36352851

RESUMO

Objectives: Evidence from systematic reviews/meta-analyses about the efficacy and safety of Qishen Yiqi (QSYQ) dripping pills in chronic heart failure (CHF) remains unclear. This study comprehensively reviewed available systematic reviews on latest evidence to provide reliable information for the clinical use of QSYQ in CHF. Methods: The systematic review was performed on studies retrieved from six major medical databases. Eligible studies were evaluated in terms of methodological quality and quality of evidence using the Assessment of Multiple Systematic review 2 (AMSTAR-2) tool, the Risk of Bias in Systematic Reviews (ROBIS) was used to assess the risk of bias, and the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) 2020 was utilized for assessing reporting quality. In addition, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to determine primary outcome indicators' evidence quality. Results: A total of 14 systematic reviews were included in this study, based on which it could be concluded that QSYQ combined with conventional medicine (CM) treatment tended to be superior to CM treatment alone in terms of improving cardiac function-related indices (e.g., increasing the left ventricular ejection fraction [LVEF] and reducing the left ventricular end-diastolic dimension [LVEDD] and left ventricular end-systolic internal diameter [LVESD]), improving the total effective rate and 6-min walking distance (6MWD), and reducing N-terminal pro-brain natriuretic peptide (NT-proBNP). Overall, no serious QSYQ-related adverse events were observed. However, the GRADE results showed "very low" to "moderate" evidence for these outcomes, with no high-quality evidence supporting them. Unsatisfactory results were obtained in terms of methodological quality, risk of bias and reporting quality after assessment using the AMSTAR-2, ROBIS, and PRISMA 2020, limited mainly by deficiencies in the following areas: registration of study protocols, explanation of the inclusion of randomized controlled trials (RCTs), complete and detailed search strategy, list of excluded literature, description of funding sources for inclusion in RCTs, investigation of the impact of risk of bias on the results of meta-analysis, and reporting of potential conflicts of interest. Conclusion: The efficacy and safety of QSYQ adjuvant therapy in CHF remain to be further clarified due to the lack of high-quality evidence provided by current systematic reviews.

5.
Opt Express ; 30(23): 42347-42361, 2022 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-36366690

RESUMO

In this paper, we employ the atomic arrays in one-dimensional optical waveguides to simulate topological phases, where the waveguide is modeled as a one-dimensional infinitely long coupled cavity array. Under the Markov approximation, the coherent and dissipative coupling between atoms is established by eliminating waveguide modes. When the detuning between atoms and cavity fields lies in the band gap, the dynamics of the system is completely dominated by the coherent interaction. Under this condition, we designed three atomic arrays with different geometries and show that the topologically trivial and non-trivial phases of atomic arrays can be simulated. Furthermore, by introducing periodic atomic driving, the topological phase transition can be induced by adjusting the driving parameters. Finally, we investigate the effect of next-nearest neighbor interactions on topological state transfer and find that the next-nearest neighbor interactions break the degenerated bandgap state and establish a topological state transfer channel.

6.
Front Pharmacol ; 13: 1058799, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36386125

RESUMO

Introduction: Chronic heart failure (CHF) is a common cardiovascular disease. In China, Xinbao pill (XBP) is widely used as an adjuvant therapy for CHF. However, there is still a lack of high-quality clinical evidence. We designed this multicenter, randomized, double-blind, placebo-controlled trial to critically evaluate the efficacy and safety of XBP as an adjuvant treatment for patients with CHF. Methods and analysis: We will recruit 284 patients with a clinical diagnosis of "heart-kidney yang deficiency syndrome" CHF receiving treatment in six hospitals in China. Patients will be randomly assigned, in a 1:1 ratio, to the treatment or control group using a central randomization system. All patients will receive conventional drug therapy for heart failure combined XBP (Guangdong Xinbao Pharmaceutical Co., Ltd., Guangdong, China) or a placebo. Study physicians, subjects, outcome assessors, and statisticians will be blinded to the group assignment. The primary outcome will be the change in the proportion of patients who show a decrease in serum NT-proBNP of more than 30% after treatment. Secondary outcomes are NYHA class, 6-minute walk distance test, Minnesota Quality of Life Scale score, endpoint events, serum NT-proBNP, echocardiographic parameters, and traditional Chinese medicine (TCM) symptom score. Adverse events will be monitored throughout the trial. Data will be analyzed according to a predetermined statistical analysis plan. Discussion: The results of this study will provide solid evidence of the safety and efficacy of XBP as an alternative and complementary treatment measure for patients with CHF. Clinical Trial Registration: Chinese Clinical Trial Registration Center (ChiCTR2000038492).

7.
Micromachines (Basel) ; 13(11)2022 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-36363849

RESUMO

This paper investigates the electrical performance of graphene-based on-chip spiral inductors by virtue of a physics-based equivalent circuit model. The skin and proximity effects, as well as the substrate loss effect, are considered and treated appropriately. The graphene resistance and inductance are combined into the circuit model. It is demonstrated that the electrical characteristics of the on-chip square spiral inductor can be improved by replacing copper with graphene. Moreover, graphene exhibits more effectiveness in improving the inductance in tapered inductors than uniform ones.

8.
Nanomaterials (Basel) ; 12(22)2022 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-36432224

RESUMO

The behavior of the magnetic field sensitivity of nitrogen-vacancy (NV) centers as a function of microwave power and the inhomogeneous distribution of MW fields was systematically studied. An optimal structure for exciting spin structures by MW signals was designed using two parallel loop antennas. The volume of the homogeneous regions was approximately 42 mm3, and the associated diameter of the diamond reached up to 5.2 mm with 1016 NV sensors. Based on this structure, the detection contrast and voltage fluctuation of an optically detected magnetic resonance (ODMR) signal were optimized, and the sensitivity was improved to 5 nT/√Hz. In addition, a pulse sequence was presented to fully eliminate the MW broadening. The magnetic field sensitivity was improved by approximately one order of magnitude as the π-pulse duration was increased to its coherence time. This offers a useful way to improve the sensitivity of spin-based sensors.

9.
Small ; : e2204630, 2022 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-36382576

RESUMO

Biomimetic stimuli-responsive structure colors (SCs) can improve the visualization and identification in the micro functional structure field such as information encryption/decryption and smart actuators. However, it is still challenging to develop the ability to 4D print arbitrary submerged colorful patterns with stimuli-responsive materials at the microscale. Herein, a hydrogel photoresist with feature resolution (98 nm) for the fabrication of 4D microscopic SCs by the femtosecond direct laser writing method is developed. The 4D printed woodpile SCs are grouped as pixel palettes with various laser parameters and they spanned almost the entire color space. The coloring mechanism of diffraction gratings is not only investigated by optics microscopy and spectroscopy but also supported by simulation. Moreover, the 4D printed hydrogel-integrated amphichromatic fish constructions and pixelated painting can visually discolor reversibly by regulating the solution pH. This finding promises an ideal coloring method for sensors, anti-counterfeiting labels, and transformable photonic devices.

10.
Front Oncol ; 12: 1021084, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36324583

RESUMO

Background: The recognition of anatomical variants is essential in preoperative planning for lung cancer surgery. Although three-dimensional (3-D) reconstruction provided an intuitive demonstration of the anatomical structure, the recognition process remains fully manual. To render a semiautomated approach for surgery planning, we developed an artificial intelligence (AI)-based chest CT semantic segmentation algorithm that recognizes pulmonary vessels on lobular or segmental levels. Hereby, we present a retrospective validation of the algorithm comparing surgeons' performance. Methods: The semantic segmentation algorithm to be validated was trained on non-contrast CT scans from a single center. A retrospective pilot study was performed. An independent validation dataset was constituted by an arbitrary selection from patients who underwent lobectomy or segmentectomy in three institutions during Apr. 2020 to Jun. 2021. The golden standard of anatomical variants of each enrolled case was obtained via expert surgeons' judgments based on chest CT, 3-D reconstruction, and surgical observation. The performance of the algorithm is compared against the performance of two junior thoracic surgery attendings based on chest CT. Results: A total of 27 cases were included in this study. The overall case-wise accuracy of the AI model was 82.8% in pulmonary vessels compared to 78.8% and 77.0% for the two surgeons, respectively. Segmental artery accuracy was 79.7%, 73.6%, and 72.7%; lobular vein accuracy was 96.3%, 96.3%, and 92.6% by the AI model and two surgeons, respectively. No statistical significance was found. In subgroup analysis, the anatomic structure-wise analysis of the AI algorithm showed a significant difference in accuracies between different lobes (p = 0.012). Higher AI accuracy in the right-upper lobe (RUL) and left-lower lobe (LLL) arteries was shown. A trend of better performance in non-contrast CT was also detected. Most recognition errors by the algorithm were the misclassification of LA1+2 and LA3. Radiological parameters did not exhibit a significant impact on the performance of both AI and surgeons. Conclusion: The semantic segmentation algorithm achieves the recognition of the segmental pulmonary artery and the lobular pulmonary vein. The performance of the model approximates that of junior thoracic surgery attendings. Our work provides a novel semiautomated surgery planning approach that is potentially beneficial to lung cancer patients.

11.
IEEE Trans Med Imaging ; PP2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36327188

RESUMO

Recently, functional brain network has been used for the classification of brain disorders, such as Autism Spectrum Disorder (ASD) and Alzheimer's disease (AD). Existing methods either ignore the non-imaging information associated with the subjects and the relationship between the subjects, or cannot identify and analyze disease-related local brain regions and biomarkers, leading to inaccurate classification results. This paper proposes a local-to-global graph neural network (LG-GNN) to address this issue. A local ROI-GNN is designed to learn feature embeddings of local brain regions and identify biomarkers, and a global Subject-GNN is then established to learn the relationship between the subjects with the embeddings generated by the local ROI-GNN and the non-imaging information. The local ROI-GNN contains a self-attention based pooling module to preserve the embeddings most important for the classification. The global Subject-GNN contains an adaptive weight aggregation block to generate the multi-scale feature embedding corresponding to each subject. The proposed LG-GNN is thoroughly validated using two public datasets for ASD and AD classification. The experimental results demonstrated that it achieves the state-of-the-art performance in terms of various evaluation metrics.

12.
Sensors (Basel) ; 22(21)2022 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-36366234

RESUMO

This study proposes an ultrahigh-sensitivity split-ring resonator-based microwave sensor for retrieving the complex permittivity of liquid samples. An interdigital capacitor structure was used to expand the sensing area and the sensitivity. A defected ground structure and A parallel dual split-ring resonator were introduced to improve the quality factor. A polydimethylsiloxane microfluidic channel substrate was placed above the interdigital capacitor structure. The channel route coincided with the interdigital gap to fully utilize the strong electric field. Ethanol-water solutions with varying ethanol fractions were injected into the channel as the testing liquid. It was demonstrated that the variation in resonant frequency can be used to retrieve the dielectric properties of liquid samples. The proposed sensor used a small liquid volume of ~0.68 µL and provided values in good agreement with the reference data.


Assuntos
Microfluídica , Micro-Ondas , Eletricidade , Etanol/química
13.
Elife ; 112022 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-36367433

RESUMO

Analyzing how gene interaction networks are perturbed in individuals can help identify different types of colorectal cancers, paving the way towards personalized care.


Assuntos
Neoplasias Colorretais , Humanos , Neoplasias Colorretais/genética , Redes Reguladoras de Genes
14.
Light Sci Appl ; 11(1): 291, 2022 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-36210366

RESUMO

Cold atoms provide a flexible platform for synthesizing and characterizing topological matter, where geometric phases play a central role. However, cold atoms are intrinsically prone to thermal noise, which can overwhelm the topological response and hamper promised applications. On the other hand, geometric phases also determine the energy spectra of particles subjected to a static force, based on the polarization relation between Wannier-Stark ladders and geometric Zak phases. By exploiting this relation, we develop a method to extract geometric phases from energy spectra of room-temperature superradiance lattices, which are momentum-space lattices of timed Dicke states. In such momentum-space lattices the thermal motion of atoms, instead of being a source of noise, provides effective forces which lead to spectroscopic signatures of the Zak phases. We measure Zak phases directly from the anti-crossings between Wannier-Stark ladders in the Doppler-broadened absorption spectra of superradiance lattices. Our approach paves the way of measuring topological invariants and developing their applications in room-temperature atoms.

15.
Mar Pollut Bull ; 184: 114186, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36307945

RESUMO

The nutrient status in Laizhou Bay has changed in composition and structure as a result of anthropogenic activities and climate change, which has led to several environmental problems (e.g., eutrophication, organic pollution and red tides). To better understand the spatiotemporal variations in dissolved inorganic nitrogen (DIN), dissolved inorganic phosphorus (DIP), and eutrophication in the Laizhou Bay, we collected historical research data and conducted four cruises in 2021. The highest surface DIN was found to occur in autumn and predominantly concentrated in the southwestern bay. The highest surface DIP content was found in winter and distributed in the northwestern bay. Surface organic pollution showed estuaries as the most polluted areas. In the past 40-60 years, the DIN, DIP, and eutrophication have shown an inverted U-shaped trend, and the bay has changed from N limitation to P limitation. Economic development, phytoplankton absorption, and bottom mineral release are factors influencing the content and distribution of nutrient in the bay.


Assuntos
Baías , Poluentes Químicos da Água , Baías/química , Monitoramento Ambiental , Poluentes Químicos da Água/análise , Eutrofização , Nitrogênio/análise , Nutrientes , China , Fósforo/análise
16.
Redox Biol ; 57: 102498, 2022 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-36242914

RESUMO

LncRNAs are involved in the pathophysiologic processes of multiple diseases, but little is known about their functions in hepatic ischemia/reperfusion injury (HIRI). As a novel lncRNA, the pathogenetic significance of hepatic nuclear factor 4 alpha, opposite strand (Hnf4αos) in hepatic I/R injury remains unclear. Here, differentially expressed Hnf4αos and Hnf4α antisense RNA 1 (Hnf4α-as1) were identified in liver tissues from mouse ischemia/reperfusion models and patients who underwent liver resection surgery. Hnf4αos deficiency in Hnf4αos-KO mice led to improved liver function, alleviated the inflammatory response and reduced cell death. Mechanistically, we found a regulatory role of Hnf4αos-KO in ROS metabolism through PGC1α upregulation. Hnf4αos also promoted the stability of Hnf4α mRNA through an RNA/RNA duplex, leading to the transcriptional activation of miR-23a and miR-23a depletion was required for PGC1α function in hepatoprotective effects on HIRI. Together, our findings reveal that Hnf4αos elevation in HIRI leads to severe liver damage via Hnf4αos/Hnf4α/miR-23a axis-mediated PGC1α inhibition.

17.
Arch Biochem Biophys ; 731: 109420, 2022 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-36183843

RESUMO

BACKGROUND: The 4-octyl itaconate (OI) is a type of cell-permeable itaconate derivative. Studies have shown that with an anti-fibrotic effect in systemic sclerosis, the OI also affects osteoclast differentiation. The aim of this study was to explore the molecular mechanisms underlying the effects of OI on myoblast differentiation by RNA-seq analysis. METHODS: Myoblast proliferation, differentiation, and muscle regulatory factors were examined in C2C12 myoblasts treated with OI of various concentrations (2.5, 10, 25, 50, and 100 µmol/L). Cells were treated with the PI3K-Akt activator IGF-1 to explore the role of the PI3K-Akt pathway in OI inhibition of myogenic differentiation. The regulatory mechanisms of OI in myogenesis were further investigated by RNA-seq and subsequent gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) and, gene set enrichment analysis (GSEA). RESULTS: OI of various concentrations did not show any effect during cell proliferation. During differentiation, OI inhibited the expressions of the marker of mature myotubes myosin heavy chain (MHC) and myogenin in a dose-dependent manner. OI inhibited muscle differentiation by affecting MyoD-regulated activity through inhibition of AKT1 phosphorylation. The results of the KEGG enrichment analysis and GSEA showed that OI affected multiple metabolic pathways during myogenic differentiation, including PI3K-Akt signaling, calcium signaling, and PPAR signaling. CONCLUSIONS: Our study broadens the understanding of the OI inhibition of myogenic differentiation. OI plays its functions by targeting multiple molecules and pathways, providing novel insights into the understanding of the overall effect of OI.


Assuntos
Fosfatidilinositol 3-Quinases , Proteínas Proto-Oncogênicas c-akt , Proteínas Proto-Oncogênicas c-akt/metabolismo , Fosfatidilinositol 3-Quinases/metabolismo , RNA-Seq , Transcriptoma , Desenvolvimento Muscular/fisiologia , Diferenciação Celular
18.
Comput Struct Biotechnol J ; 20: 5226-5234, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36187930

RESUMO

Tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2) is encoded by TNFAIP8L2 and is a newly identified negative regulator of natural and acquired immunity that plays a critical function in maintaining immune homeostasis. Recently, CAR-NK immune cell therapy has been a focus of major research efforts as a novel cancer therapeutic strategy. TIPE2 is a potential checkpoint molecule for immune cell maturation and antitumor immunity that could be used as a novel NK cell-based immunotherapeutic approach. In this study, we explored the expression of TNFAIP8L2 across various tumor types and found that TNFAIP8L2 was highly expressed in most tumor types and correlated with prognosis. Survival analysis showed that TNFAIP8L2 expression was predictive of improved survival in cervical-squamous-cell-carcinoma (CESC), sarcoma (SARC) and skin-cutaneous-melanoma (SKCM). Conversely, TNFAIP8L2 expression predicted poorer survival in acute myeloid leukemia (LAML), lower-grade-glioma (LGG), kidney-renal-clear-cell-carcinoma (KIRC) and uveal-melanoma (UVM). Analysis of stemness features and immune cell infiltration indicated that TNFAIP8L2 was significantly associated with cancer stem cell index and increased macrophage and dendritic cell infiltration. Our data suggest that TNFAIP8L2 may be a novel immune checkpoint biomarker across different tumor types, particularly in LAML, LGG, KIRC and UVM, and may have further utility as a potential target for immunotherapy.

19.
iScience ; 25(10): 105177, 2022 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-36238897

RESUMO

The emergence of the optically pumped magnetometer (OPM)-based magnetoencephalography (MEG) has led to new developments in MEG technology. The source imaging results of different magnetic source imaging (MSI) methods show considerable differences, which makes it difficult for researchers to choose an appropriate method. This study assessed time-domain MSI methods implemented in the Brainstorm, FieldTrip, and SPM12 toolboxes using simulations. We proposed using a metric, variational free energy under the Bayesian framework, as an indicator to evaluate source imaging results because it does not require the ground truth of sources but uses the fitness of the measurement data. Our simulations demonstrated the effectiveness of the variational free energy in indicating the quality of the source reconstruction results. We then applied each MSI method to the real OPM-MEG experimental data. We aimed to highlight the characteristics of each method and provide references for researchers choosing an appropriate MSI method.

20.
Chem Commun (Camb) ; 58(84): 11803-11806, 2022 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-36184912

RESUMO

A porphyrin containing covalent organic framework (COF) was developed as the glutathione responsive nitric oxide (NO) donor delivery nanoplatform for "1 + 1 > 2" synergistic cancer therapy of NO mediated therapy and photodynamic therapy.


Assuntos
Estruturas Metalorgânicas , Neoplasias , Fotoquimioterapia , Porfirinas , Humanos , Estruturas Metalorgânicas/farmacologia , Óxido Nítrico , Porfirinas/farmacologia , Neoplasias/tratamento farmacológico , Glutationa , Linhagem Celular Tumoral
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