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1.
Sci Total Environ ; 855: 158872, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36122727

RESUMO

The elusive sources of air pollution have hampered effective control across all sectors, with long-term consequences for the greenhouse effect and human health. Multiple monitoring systems have been highly desired for locating the sources. However, when faced with extensive sources, diverse air environments and meteorological conditions, the low spatiotemporal resolution, poor reliability and high cost of existing monitors were significant obstacles to their applications. Extending our previous demonstration of sensitive and reliable electrochemical sensors, we here present a machine-learning-assisted sensor arrays for monitoring typical volatile organic compounds (VOCs), which shows the consistent response with gas chromatography-mass spectrometry in the actual air environment. As a proof-of-concept, a low-cost and high-resolution VOC network of 152 sets of monitors across ~55 km2 of mixed-used land is established in southwest Beijing. Benefiting from the strong reliability, the pollution sources are revealed by the VOC network and supported by the joint mobile sampling of a vehicle-mounted gas chromatography-mass spectrometry system. With the sustained help of the network, the sources polluted by the local industrial facilities, traffic, and restaurants are effectively site-specific abatement by the local authorities and enterprises during the next half-year. Our findings open up a promising path toward more effective tracing of regional pollution sources, as well as accelerate the long-term transformation of industry and cities.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Ozônio , Compostos Orgânicos Voláteis , Humanos , Compostos Orgânicos Voláteis/análise , Poluentes Atmosféricos/análise , Reprodutibilidade dos Testes , Monitoramento Ambiental/métodos , Poluição do Ar/análise , China , Ozônio/análise
2.
J Colloid Interface Sci ; 629(Pt A): 434-444, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36087556

RESUMO

Anthraquinone have desirable redox property, high specific capacity, and structural diversity, making them standing out as candidate cathode materials. However, they are still restricted in long cycling life for aqueous Zn-ion batteries (ZIBs) due to the structural instability and dissolution during the repeated H+/Zn2+ co-intercalation commonly leads to a fast capacity fading. Herein, two completely new isomeric porous polymers PTA-O26 and PTA-O14 with triazine have been designed and synthesized. The impact of the location of anthraquinone units on the redox potentials, Zn2+/H+ co-insertion behavior, and battery performance of polymer electrodes has been systematically studied. Experimental and DFT calculations studies clearly reveal the outstanding structural symmetry and highly reversible redox reaction for PTA-O26 cathode, which can effectively tackle the bottleneck problems for ZIBs on aspects of structural stability and Zn2+/H+ co-insertion dynamics. Naturally, PTA-O26 displays a specific capacity of 296 mAh g-1 after 250 cycles with a high-capacity retention of 92.2 %.Moreover, the flexible soft-packaged battery by using PTA-O26 as cathode coupled with Zn foil as counter electrode manifests good stability under different bending conditions. The study provides a new insight about how to tune the structures for high performance batteries.

3.
Sci Total Environ ; 856(Pt 2): 158930, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36179831

RESUMO

Coal seam water injection, as an important disaster prevention means in the process of coal mining, can effectively suppress coal dust, add water injection additives, can effectively improve the wettability of coal body, improve the permeability of coal body, so as to achieve the prevention of rock burst. To improve the wettability of coal in coal seam water injection, the surfactant is often added to water, but sodium dodecyl benzene sulfonate (SDBS) and sodium dodecyl sulfate (SDS) have limitations in improving wettability of deep coal seam by injecting water. Therefore, it is very important to determine the influencing factors of SDBS and SDS to improve the wettability of coal. In this paper, the effects of oxygen-containing functional groups and minerals in coal on the wettability of coal are revealed, and the wettability mechanism of SDBS and SDS is expounded from the microscopic point of view. SEM was used to characterize the interaction between coal surface and surfactant, and the contact angle experiment was used to verify the influence of minerals in coal on wettability. Inductively coupled plasma atomic emission spectroscopy (ICP) and dynamic light scattering (DLS) tests were used to characterize the interaction of SDBS, SDS with minerals and the size of precipitation generated by the interaction of SDBS, SDS and mineral ions. The results showed that SDBS and SDS interact with Ca2+ to produce precipitation and block the flow of water in coal, which is not conducive to improving the wettability of deep coal seam to a certain extent. The significant chelating effect of chelating agent and Ca2+ provides a feasible solution to this problem.


Assuntos
Minas de Carvão , Carvão Mineral , Água , Dodecilsulfato de Sódio/química , Tensoativos/química , Minas de Carvão/métodos
4.
J Affect Disord ; 320: 667-673, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36209781

RESUMO

OBJECTIVES: To explore the effect of time to remission on residual symptoms, functioning and quality of life (QOL) of the patients with major depressive disorder (MDD). METHOD: A total of 434 patients were enrolled from 16 sites of China. The Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR) and self-rating scales were assessed at baseline, and months 1, 3 and 6. Baseline remitters were defined as those subjects with a QIDS-SR score ≤ 5 at baseline. Later remitters was defined as those reaching remission one month (Month 1 remitters) or three month (Month 3 remitters) after baseline. Persistent non-remitters were defined as those with QIDS-SR score > 5 at all 3 assessments. A follow-up assessment was done at month 6 to examine outcomes. Cross-lagged models indicated QIDS-SR predicted social functioning and QOL. RESULTS: Totally, 179 patients at baseline achieved remission. An additional 141 participants remitted at month 1 (n = 94) or month 3 (n = 47), and 63 patients were persistent non-remitters. There were significant differences between all groups on depression severity at baseline. QOL was similar for both late remitter groups, which was better than non-remitters, but lower than early-remitters. Late remitters and non-remitters showed significant differences on change of functioning and QOL (P < 0.001) at each visit. By 6 months, all remitting groups showed lower depression severity and better social functioning and QOL than persistent non-remitters. Cross-lagged models indicated QIDS-SR predicted social functioning and QOL. CONCLUSION: We confirmed the association of earlier remission with a better quality of remission at early stage; but the time to remission does not affect future functioning and QOL.


Assuntos
Transtorno Depressivo Maior , Humanos , Transtorno Depressivo Maior/tratamento farmacológico , Transtorno Depressivo Maior/diagnóstico , Qualidade de Vida , Escalas de Graduação Psiquiátrica , Autorrelato , China
5.
Phytomedicine ; 108: 154514, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36334390

RESUMO

BACKGROUND: A wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant rapidly resulted in a steep increase in the infected population and an overloaded healthcare system. Effective medications for Omicron are currently limited. The previous observational study supports the efficacy and safety of Reyanning (RYN) mixture in the treatment of coronavirus disease 2019 (COVID-19). PURPOSE: To evaluate the efficacy of RYN in asymptomatic and mildly infected patients with SARS-CoV-2 infection. STUDY DESIGN AND METHODS: This study was a prospective, open-label, randomized controlled trial. We consecutively recruited 2830 patients from Shanghai New International Expo Center mobile cabin hospital and randomized them in a 1:1 ratio to receive RYN plus standard care or receive standard care alone. The primary outcomes were the negative conversion of nucleic acid. Secondary outcomes included the hospital duration, new-onset symptoms, proportion of disease progression, and the viral load measured by the cycle threshold (Ct) value. RESULTS: A total of 1393 patients in the intervention group and 1407 patients in the control group completed the study. The negative conversion time of nucleic acid was significantly shortened in the intervention group (median: 6 d vs. 7 d, Hazard ratio: 0.768, 95CI %: 0.713-0.828, p < 0.0001). The negative conversion rate of nucleic acid was significantly higher in the intervention group (Day 3: 32.4% vs. 18.3%; Day7: 65.3% vs. 55.2%, p < 0.001). The hospitalization duration was significantly shortened in the intervention group (median: 8 d vs. 9 d, Hazard ratio: 0.759, 95% CI: 0.704-0.818, p < 0.0001). The proportion of new-onset fever (2.4% vs. 4.1%, p = 0.012), coughing (12.2% vs. 14.8%, p = 0.046), and expectoration (6.0% vs. 8.0%, p = 0.032) in the intervention group was significantly lower. RYN treatment increased Ct values and reduced the viral load. No disease progression and serious adverse events were reported during the study. CONCLUSION: RYN is a safe and effective treatment that can accelerate virus clearance and promote disease recovery in asymptomatic and mild Omicron infections.

6.
J Colloid Interface Sci ; 631(Pt B): 1-7, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36379111

RESUMO

Stretchable lithium-ion batteries (SLIBs) hold great potential as a power source for wearable electronics. A major challenge in the development of SLIBs is fabricating stable and reliable stretchable electrodes. Herein, we develop a novel laser-structured microarray electrodes based SLIBs. An active material film adhered to a planar stretchable current collector is ablated by ultrafast laser into an independent microscale square array, enabling electrodes stretchable. A one-dimensional elastic analytical model is developed to evaluate the stretchability of the microarray electrodes under tensile conditions. The microscale square array adheres to the current collector and keeps intact if the shear stress is less than the adhesion force as well as the tensile stress is less than the tensile strength of the active material. The demonstrated electrodes have a mass active material loading of 10 mg cm-2 and maintain robust electrochemical performance when stretched beyond 500 cycles at 100 % strains. The fabricated SLIBs show a stable capacity of 1.2 mAh cm-2, and over 70 % of initial capacity can be maintained at 100 % strain.

7.
Sci Total Environ ; 857(Pt 1): 159293, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36209881

RESUMO

Wind energy is renewable and clean; however, the long-term operation of wind turbines can affect local climates. Soil moisture affects ecosystem balance, so determining the impact of wind farms on soil moisture is important. However, there has been little research on this, and only the impacts of wind farms on climate and vegetation have been considered. This study focuses on wind farms located in the grasslands of China. We analyzed changes in soil moisture in different wind directions and seasons and then judged the impacts of wind turbine operation on soil moisture. Our research shows that the operation of wind turbines will cause significant drying of soil, and this drought effect differs significantly according to season and wind direction. Our results show that 1) the soil moisture within wind farms decreases most significantly, with a decrease of 4.4 % observed; 2) in summer and autumn, the declines in soil moisture in the downwind direction are significantly greater than those in the upwind direction, with the opposite occurring in spring. (3) Wind farms aggravate the soil drying in grassland areas, which may have impacts on grassland ecosystems. Therefore, when building wind farms, we need to better understand their impacts on the environment.

8.
Microbiol Res ; 266: 127225, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36240664

RESUMO

Salt stress poses a global challenge for agriculture, crop growth, and food production. In this study, a strain of rhizobacteria with both plant growth-promoting (PGP) traits and salt tolerance was isolated. The strain was identified as Bacillus pumilus via 16 S rDNA sequencing and was named B. pumilus JIZ13. This strain had the potential to solubilize phosphates and produce 1-aminocyclopropane-1-carboxylic acid deaminase, siderophores, and indole-3-acetic acid. After 35 days of salt stress exposure, the root length, plant height, dry weight, fresh weight, and relative water content of rice plants inoculated with strain JIZ13 were significantly higher than those without inoculation. Interestingly, the PGP properties of strain JIZ13 were significantly improved by the exogenous addition of gamma-aminobutyric acid (GABA). Moreover, GABA also enhanced the growth and development of rice plants under salt stress by providing substrates for the tricarboxylic acid cycle. Furthermore, the synergistic roles of GABA and strain JIZ13 in mitigating the damage caused by salt stress in rice plants was investigated. The results showed that the co-application of GABA and JIZ13 significantly increased photosynthetic efficiency, chlorophyll accumulation, antioxidant levels, levels of osmotic adjustment substances, and biomass of rice under salinity stress. In addition, the activities of urease, protease, invertase, and catalase enzymes in soil significantly improved under the combination of strain JIZ13 and GABA and increased by 39.65%, 36.88%, 70.21%, and 65.23%, respectively, compared to those without rhizobacterial and GABA additions. The enhancement of these four soil enzyme activities might thus improve soil quality and increase root elongation and biomass in rice plants. The results of this study provide the first evidence that PGP-rhizobacterial strain JIZ13 along with GABA can attenuate the negative effects of salt stress in rice plants.

9.
Gen Psychiatr ; 35(1): e100751, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35372787

RESUMO

China's population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated, especially Alzheimer's disease (AD) and related dementias (ADRD). AD's incidence rate, morbidity, and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals, families and society. The 'Healthy China Action' plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD. This report describes related epidemiological trends, evaluates the economic burden of the disease, outlines current clinical diagnosis and treatment status and delineates existing available public health resources. More specifically, it examines the public health impact of ADRD, including prevalence, mortality, costs, usage of care, and the overall effect on caregivers and society. In addition, this special report presents technical guidance and supports for the prevention and treatment of AD, provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation.

10.
ACS Omega ; 7(43): 38322-38336, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36340166

RESUMO

To determine the factors affecting the gas emission in the working face during the horizontal sublevel mining of steeply inclined and ultrathick coal seams (SIUTCSs), the gas emission sources were identified and evaluated using the analytic hierarchy process (AHP), and the gas emission quantity was calculated using a prediction model. Sobol sensitivity analysis was then conducted on the influencing factors involved in the model to determine their influences on the working face gas emission. The AHP analysis found that the pressure relief area in the lower section is the main gas emission source of the working face, and the adjacent coal seams, old goaf, and rear goaf are not. The gas emission prediction model exhibits good accuracy. The calculation results suggest that the gas released from the lower section coal body accounts for 44.16-50.44% of the total gas emission quantity of the working face, and thus, it is the main gas emission source. The Sobol sensitivity analysis reveals that the dip angle of the coal seam has the greatest influence on the absolute gas emission quantity of the working face with a significantly larger sensitivity than those of other factors. The comprehensive sensitivity data analysis also suggests that the lower section coal body is the major contributor to the gas emission of the working face. Our work further puts forward a technical system of ultrahigh pressure hydraulic "drilling-slitting-pressing-draining" integrated antireflection enlarged gas extraction for controlling the gas emission from the coal body at the bottom of the SIUTCS. The engineering test demonstrates that this system can increase the permeability of the coal body and significantly improve the gas extraction efficiency of the coal body in the study area.

11.
Hematology ; 27(1): 1204-1207, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36330781

RESUMO

A 37-year-old Chinese man complained of recurrent dyspnea, with low pulse oximetry (SpO2) and normal partial pressure of oxygen (PaO2) by blood gas analysis. The patient's P50 was elevated at 47.3 mmHg, while hemoglobin fraction by capillary electrophoresis revealed an abnormal HbD quantified at 43.2%. Further DNA analysis by whole exome sequencing (WES) identified heterozygosity for a mutation in exon 2 at codon 38 (HBB: c.112T>A, p.Trp38Arg), which decodes to a substitution of the amino acid tryptophan (Try) by arginine (Arg), known as Hb Rothschild. The patient's mother and daughter were also diagnosed to have low SpO2 readings and his daughter was confirmed to carry Hb Rothschild. This is the first known familial case of Hb Rothschild in China. As Hb Rothschild may be underdiagnosed in Asian descent, better understanding in this area would help avoid unnecessary cardiorespiratory interventions.


Assuntos
Hemoglobinas Anormais , Masculino , Humanos , Adulto , Hemoglobinas Anormais/genética , Hemoglobinas Anormais/metabolismo , Oximetria , Códon , Oxigênio , Mutação , Globinas beta/genética
12.
Front Bioeng Biotechnol ; 10: 1023693, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36338132

RESUMO

Continuous cropping obstacle (CCO) in tobacco is a prevalent and intractable issue and has not yet been effectively solved. Many researchers have favored exploring environmentally friendly and sustainable solutions to CCO (e.g, the application of (bio-) organic fertilizers). Therefore, to study the effects of functional organic fertilizers (FOFs) on tobacco CCO, we applied five types of fertilizers in a tobacco continuous cropping field with red soil (i.e., CF: tobacco-special chemical fertilizers; VOF: vermicompost-based FOF; HOF: humic acid-based FOF; WOF: wood biochar-based FOF; COF: compound FOF). The tobacco plant agronomic traits, leaf yield, economic value, and chemical quality (nicotine, total sugar, K2O, Cl contents, etc.) were evaluated via the continuous flow method. Meanwhile, we determined rhizosphere soil physicochemical properties, phenolic acids content, and bacterial community diversity by high-throughput sequencing. The results show that FOFs improved the tobacco plant agronomic traits, leaf yield (by 2.9-42.8%), value (by 1.2-47.4%), and chemical quality when compared with CF. More content of NH4 +-N, available P, and available K were discovered in the rhizosphere soil in VOF, HOF, and WOF. The rhizosphere sinapic acid and total phenolic acids content declined in the FOF treatments (1.23-1.56 and 7.95-8.43 mg kg-1 dry soil, respectively) versus those in the CF treatment (2.01 and 10.10 mg kg-1 dry soil, respectively). Moreover, the rhizosphere bacterial community structure changed under FOF functions: the beneficial microbes Actinobacteria, Firmicutes, Streptomyces, and Bacillus increased, and the harmful microbes Acidobacteria and Gemmatimonadota decreased in abundance. There was a positive correlation between the tobacco leaf yield and soil NH4 +-N, TC content, and the relative abundance of Proteobacteria and Actinobacteriota. In summary, the application of VOF and WOF is a modest, practical, and environmentally friendly strategy to alleviate tobacco CCO from the standpoint of recycling solid waste.

13.
Nutrients ; 14(21)2022 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-36364729

RESUMO

Menopause is a period during which women undergo dramatic hormonal changes. These changes lead to physical and mental discomfort, are greatly afflictive, and critically affect women's lives. However, the current safe and effective management measures for women undergoing menopause are insufficient. Several probiotic functions of lactic acid bacteria (LAB) have been recognized, including alleviation of lactose intolerance, protection of digestive tract health, activation of the immune system, protection against infections, improvement of nutrient uptake, and improvement of the microbiota. In this review, we highlight the currently available knowledge of the potential protective effects of LAB on preventing or mitigating menopausal symptoms, particularly in terms of maintaining balance in the vaginal microbiota, reducing bone loss, and regulating the nervous system and lipid metabolism. Given the increasing number of women entering menopause and the emphasis on the management of menopausal symptoms, LAB are likely to soon become an indispensable part of clinical/daily care for menopausal women. Herein, we do not intend to provide a comprehensive analysis of each menopausal disorder or to specifically judge the reliability and safety of complementary therapies; rather, we aim to highlight the potential roles of LAB in individualized treatment strategies for the clinical management of menopause.


Assuntos
Terapias Complementares , Lactobacillales , Feminino , Humanos , Terapia de Reposição de Estrogênios , Reprodutibilidade dos Testes , Menopausa/fisiologia
14.
Virol J ; 19(1): 186, 2022 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-36372879

RESUMO

BACKGROUND: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which is currently a worldwide pandemic. There are limited available treatments for severe COVID-19 patients. However, some evidence suggests that intravenous immunoglobulin (IVIg) provides clinical benefits for these patients. METHODS: We administered IVIg to 23 severe COVID-19 patients, and all of them survived. Four related coronaviruses can cause the common cold. We speculated that cross-reactivity of SARS-CoV-2 and other common coronaviruses might partially explain the clinical efficacy of IVIg therapy. Thus, we performed multiple alignment analysis of the spike (S), membrane (M), and nucleotide (N) proteins from SARS-CoV-2 and the common coronaviruses to identify conserved regions. Next, we synthesized 25 peptides that were conserved regions and tested their IVIg seropositivity. RESULTS: The results indicated four peptides had significant or nearly significant seropositivity, and all of them were associated with the S and M proteins. Examination of the immune responses of healthy volunteers to each synthetic peptide indicated high seropositivity to the two peptides from S protein. Blood samples from healthy individuals may have pre-existing anti-SARS-CoV-2 IgGs, and IVIg is a potentially effective therapy for severe COVID-19. CONCLUSION: In conclusion, blood samples from many healthy individuals have pre-existing anti-SARS-CoV-2 IgGs, and IVIg may be an effective therapy for severe COVID-19.


Assuntos
COVID-19 , SARS-CoV-2 , Humanos , COVID-19/tratamento farmacológico , Glicoproteína da Espícula de Coronavírus , Imunoglobulinas Intravenosas/uso terapêutico , Anticorpos Antivirais/uso terapêutico , Imunoglobulina G
15.
J Orthop Translat ; 37: 152-162, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36380884

RESUMO

Background: /Objective: Tissue engineering involves scaffolds, cells and growth factors, among which growth factors have limited applications due to potential safety risks and high costs. Therefore, an alternative approach to exogenously induce osteogenesis is desirable. Considering that osteogenesis and angiogenesis are coupled, a system of human umbilical vein endothelial cells (HUVECs) and human bone mesenchymal stem cells (hBMSCs) coculture is more biologically adapted to the microenvironment in vivo and can mediate osteogenesis and angiogenesis via paracrine signalling. Hence, in this study, a HUVECs/hBMSCs coculture system with appropriate cell and medium proportions was established. The substrate for the coculture system was a 3D-printed composite bioceramic scaffold (ß-TCP/CaSiO3) based on a previous study. The aim of this study was to explore the potential of this system for bone tissue engineering. Methods: Bioactive ceramic scaffolds for tissue engineering were fabricated via a 3D Bioplotter™ system. The coculture system for in vitro and in vivo studies consisted of direct contact between HUVECs and hBMSCs cultured on the 3D-printed scaffolds. Results: The proportions of HUVECs/hBMSCs and medium components were determined by cell viability, and the coculture system showed negligible cytotoxicity. CD31 secreted by HUVECs formed strings, and cells tended to aggregate in island chain-like arrays. Real-time cell tracking showed that HUVECs were recruited by hBMSCs, and the integrin expression by HUVECs was upregulated. Ultimately, osteogenic and angiogenic marker gene expression and protein secretion were upregulated. Moreover, the obtained bone tissue engineering scaffolds could induce early osteogenic protein secretion and capillary tube formation in nude rats. Conclusion: These bone tissue engineering scaffolds without exogenous growth factors exhibited the ability to promote osteogenesis/angiogenesis. Translational potential of this article: The fabricated 3D-printed bioactive ceramic scaffolds could provide mechanical, biodegradable and bioadaptive support for personalized bone regeneration. In addition, the bone tissue engineering scaffolds exhibited the ability to promote osteogenesis/angiogenesis without the addition of exogenous growth factors, thus mitigating safety risks. Although application of the HUVECs/hBMSCs coculture system might be a time-consuming process, further development of cord blood storage could be beneficial for multicell coculture.

16.
Artigo em Inglês | MEDLINE | ID: mdl-36385699

RESUMO

INTRODUCTION: Real-world data are limited comparing Asian and White patients with psoriasis using biologic therapy. This study compared the 6-month effectiveness of biologic therapy between Asian and White plaque patients with psoriasis in the CorEvitas Psoriasis Registry. METHODS: Analyses included biologic initiations and 6-month follow-up visits from self-identified Asian (n = 293) and White (n = 2314) patients in the USA/Canada (4/2015-4/2020). Outcomes included: Psoriasis Area Severity Index (PASI) 75, disease activity measures [body surface area (BSA) ≤ 1, BSA ≤ 3, PASI90, PASI100, Investigator's Global Assessment (IGA) 0/1], and patient-reported outcomes [Dermatology Life Quality Index (DLQI) 0/1, itch, fatigue, skin pain, EuroQoL visual analog scale (EQ-VAS), patient global assessment, Work Productivity Activity and Impairment (WPAI) domains]. Unadjusted regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI) for achievement of binary outcomes and difference in mean change in continuous outcomes (ß, 95% CI) at 6 months, followed by adjustment for age, sex, body mass index, alcohol, smoking, health insurance, education, comorbidities, scalp psoriasis morphology, psoriatic arthritis, biologic class, previous biologics, and baseline outcome value. RESULTS: Asians had lower proportions of women (32.8% versus 49.1%) and obesity (27.3% versus 54.5%), and higher proportions on Medicaid (19.9% versus 8.8%), graduated college (50.9% versus 40.1%) and never smoked (67.1% versus 44.1%). In unadjusted analyses, Asians had 52% higher odds of achieving PASI75 versus White patients (OR 1.52; 95% CI 1.15, 2.02). After adjustment, the association was attenuated (OR 1.11; 0.81, 1.52). Secondary outcomes experienced similar patterns except for DLQI: Asians had 33% lower odds of achieving DLQI 0/1 in both the unadjusted (OR 0.67; 0.50, 0.90) and adjusted (OR 0.67; 0.49, 0.92) models. CONCLUSION: Unadjusted differences in biologic therapy effectiveness between Asians compared with White patients were likely explained by differences in demographic, lifestyle, and psoriatic disease characteristics between groups. However, Asians still experienced lesser improvements in skin-related quality of life, even after adjustment.

17.
Front Neurorobot ; 16: 1047325, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36406950

RESUMO

The use of upper limb rehabilitation robots to assist the affected limbs for active rehabilitation training is an inevitable trend in the field of rehabilitation medicine. In particular, the active motion intention-based control of the upper limb rehabilitation robots to assist subjects in rehabilitation training is a hot research topic in human-computer interaction control. Therefore, improving the accuracy of active motion intention recognition is the premise of the human-machine interaction controller design. Furthermore, there are external disturbances (bounded/unbounded disturbances) during rehabilitation training, which seriously threaten the safety of subjects. Thereby, eliminating external disturbances (especially unbounded disturbances) is the difficulty and key to the human-machine interaction control of the upper limb rehabilitation robots. In response to these problems, based on the surface electromyogram signal of the human upper limb, this paper proposes a fuzzy neural network active motion intention recognition method to explore the internal connection between the surface electromyogram signal of the human upper limb and active motion intention, and improve the real-time and accuracy of recognition. Based on this, two types of human-machine interaction controllers, which can be called as zeroing neural network controller and noise-suppressing zeroing neural network controller are designed to establish a safe and comfortable training environment to avoid secondary damage to the affected limb. Numerical experiments verify the feasibility and effectiveness of the proposed theories and methods.

18.
Artigo em Inglês | MEDLINE | ID: mdl-36409973

RESUMO

RATIONALE: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. OBJECTIVES: To explore the plasticity of individual lung function states during childhood. METHODS: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort. MEASUREMENTS AND MAIN RESULTS: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low/very low states and 36 (2.4%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development. CONCLUSIONS: Individual lung function states during childhood are plastic, including catch-up and growth failure.

19.
Front Pharmacol ; 13: 963614, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36386155

RESUMO

High invasiveness is a biological and clinical characteristic of glioblastoma and predicts poor prognosis of patients. Quercetin, a natural flavonoid compound, exhibits anticancer activity. However, we have a limited understanding of the possible underlying mechanism of quercetin in glioblastoma. In this study, we investigated the anticancer effect of quercetin in human glioblastoma cells. Our results showed that quercetin markedly suppressed the viability of glioblastoma cells in vitro and in vivo, and significantly inhibited glioblastoma cell migration and invasion. Moreover, quercetin reversed EMT-like mesenchymal phenotype and reduced the expression levels of EMT-related markers. Furthermore, we found that quercetin suppressed GSK-3ß/ß-catenin/ZEB1 signaling in glioblastoma. Taken together, our results demonstrate that quercetin inhibited migration and invasion of human glioma cells by suppressing GSK3ß/ß-catenin/ZEB1 signaling. Our study provides evidence that quercetin is a promising therapeutic natural compound to treat glioblastoma.

20.
Front Surg ; 9: 928659, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36386538

RESUMO

Background: The inflammation and nutrition status are crucial factors influencing the outcome of patients with gastric cancer. This study aims to investigate the prognostic value of the preoperative prognostic nutritional index (PNI) in patients with stage I-III gastric cancer undergoing robotic radical gastrectomy combined with Enhanced Recovery after Surgery (ERAS), and further to create a clinical prognosis prediction model. Study: 525 patients with stage I-III gastric cancer who underwent ERAS combined with RRG from July 2010 to June 2018 were included in this work, and were divided randomly into training and validating groups in a 7-to-3 ratio. The association between PNI and overall survival (OS) was assessed by Kaplan-Meier analysis and the log-rank test. Independent risk factors impacting postoperative survival were analyzed with the Cox proportional hazards regression model. A nomogram for predicting OS was constructed based on multivariate analysis, and its predictive performance was evaluated using Harrell's concordance index (C-index), calibration plots, ROC curve, decision curve analysis (DCA), and time-dependent ROC curve analysis. Results: Survival analyses revealed the presence of a significant correlation between low preoperative PNI and shortened postoperative survival (P = 0.001). According to multivariate analysis, postoperative complications (P < 0.001), pTNM stage (II: P = 0.007; III: P < 0.001), PNI (P = 0.048) and lymph node ratio (LNR) (P = 0.003) were independent prognostic factors in patients undergoing ERAS combined with RRG. The nomogram constructed based on PNI, pTNM stage, complications, and LNR was superior to the pTNM stage model in terms of predictive performance. The C-indexes of the nomogram model were respectively 0.765 and 0.754 in the training and testing set, while AUC values for 1-year, 3-year, and 5-year OS were 0.68, 0.71, and 0.74 in the training set and 0.60, 0.67, and 0.72 in the validation set. Conclusion: Preoperative PNI is an independent prognostic factor for patients with stage I-III gastric cancer undergoing ERAS combined with robotic radical gastrectomy. Based on PNI, we constructed a nomogram for predicting postoperative outcomes of gastric cancer patients, which might be utilized clinically.

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