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1.
Food Chem ; 370: 130979, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34543921

RESUMO

Hops are abundant in natural bioactive compounds. In this work, nine prenylated bitter compounds from hop were evaluated for their inhibitory activity against α-glucosidase. As a result, four flavonoids and one phloroglucinol (lupulone, LP) outperformed acarbose in inhibiting α-glucosidase. Isoxanthohumol (IX) and LP with two types of structures were selected for inhibition mechanism studies by spectroscopic methods and molecular dynamics simulation (MD). Results showed that IX acted as noncompetitive inhibitor and bound to α-glucosidase in allosteric sites via hydrogen bonds, hydrophobic, van der Waals (vdW), and electrostatic force, whereas LP was uncompetitive inhibitor and bound to catalytic sites via hydrophobic and vdW interactions. Notably, the conformation around binding site of α-glucosidase formed stable α-helix and tightened after binding IX and LP, respectively, which helped to elucidate noncompetitive and uncompetitive inhibitory mechanisms. This work demonstrated that two types of prenylated bitter compounds are discrepant in their mechanisms of interaction with α-glucosidase.


Assuntos
Humulus , Simulação por Computador , Flavonoides , Paladar , alfa-Glucosidases
2.
J Colloid Interface Sci ; 607(Pt 2): 1562-1570, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34583051

RESUMO

Silicon combines the advantages of high theoretical specific capacity, low potential and natural abundance, which exhibits great promise as an anode for lithium-ion batteries. However, the main challenges associated with Si anode are continuous volume expansion upon cycling and intrinsic low electronic conductivity, leading to sluggish reaction kinetics and rapid capacity fading. Herein we propose a novel in-situ self-catalytic strategy for the growth of highly graphitic carbon to encapsulate Si nanoparticles by chemical vapor deposition, where the magnesiothermic reduction byproducts are used as templates and catalysts for the formation of three-dimensional (3D) conductive network architecture. Benefiting from the improved electronic conductivity and significant suppression of volume expansion, the as-synthesized Si carbon composites exhibit excellent lithium storage capabilities in terms of high specific capacity (2126 mAh g-1 at 0.1 A g-1), remarkable rate capability (750 mAh g-1 at 5 A g-1), and good cycling stability over 450 cycles. Furthermore, the as-fabricated full cell (Si//Ni-rich LiNi0.815Co0.185-xAlxO2) shows high energy density of 395.1 Wh kg-1 and long-term stable cyclability. Significantly, this work demonstrates the effectiveness of in-situ self-catalysis reaction by using magnesiothermic reduction byproducts catalytically derived carbon matrix to encapsulate alloy-type anode material in giving rise to the overall energy storage performance.

3.
J Hazard Mater ; 422: 126821, 2022 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-34419843

RESUMO

Removal of antimony from wastewater is essential because of its potential harm to the environment and human health. Nano-silica and biogenic iron (oxyhydr)oxides composites (BS-Fe) were prepared by iron oxidizing bacteria (IOB) mediation and the batch adsorption experiments were applied to investigate antimonite (Sb(III)) and antimonate (Sb(V)) removal behaviors. By contrast, the synthetic BS-Fe calcined at 400 â„ƒ (BS-Fe-400) exhibited a large specific surface area (157.353 m2/g). The maximum adsorption capacities of BS-Fe-400 were 102.10 and 337.31 mg/g for Sb(III) and Sb(V), respectively, and experimental data fit well to the Langmuir isotherm and Temkin models, and followed the pseudo-second order kinetic model. Additionally, increasing pH promoted Sb(III) adsorption, while inhibited the adsorption of Sb(V), indicating that electrostatic attraction made a contribution to Sb(V) adsorption. Moreover, different co-existing ions showed different effects on adsorption. Characterization techniques of FTIR and XPS indicated that the main functional groups involved in the adsorption were -OH, C-O, CO, C-C, etc. and Sb(III) and Sb(V) may bind to iron (oxyhydr)oxides via the formation of inner-sphere complexes. The present work revealed that the synthetic BS-Fe-400 by nano-silica and biogenic iron (oxyhydr)oxides held great application potential in antimony removal from wastewater.


Assuntos
Antimônio , Poluentes Químicos da Água , Adsorção , Bactérias , Humanos , Ferro , Oxirredução , Óxidos , Dióxido de Silício
4.
J Affect Disord ; 296: 189-197, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34607060

RESUMO

BACKGROUND: The symptoms that patients with major depressive disorder (MDD) experience are the dominant contributing factors to its heavy disease burden. This study sought to identify key symptoms leading to disability in patients with MDD. METHODS: Subjects consisted of patients who had a 12-month MDD diagnosis based on the China Mental Health Survey (CMHS). World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess the degree of disability. The associations between depressive symptoms and disability were analyzed using a linear regression and logistic regression with a complex sampling design. RESULTS: Of the 32,552 community residents, 655 patients were diagnosed with 12-month MDD. The disability rate due to MDD was 1.06% (95% CI: 0.85%-1.28%) among adults in Chinese community and 50.7% (95% CI: 44.3%-57.1%) among MDD patients. Depression was associated with all functional losses measured by the WHODAS. Feelings of worthlessness in life or inappropriate guilt, and psychomotor agitation or retardation were the key symptoms related to disability. Economic status, co-morbidity of physical diseases or anxiety disorders were correlates of disability scores. LIMITATIONS: The disability rate might be underestimated due to the exclusion of MDD patients living in hospitals. The effect of treatments on disability was excluded. CONCLUSIONS: Psychological symptoms, not somatic symptoms, contribute to disability in MDD patients. Disability worsens when physical diseases or anxiety disorders are present. More attention could be paid to psychological symptoms, physical diseases, and anxiety disorders in MDD patients with disabilities.

5.
Artigo em Inglês | MEDLINE | ID: mdl-34859994

RESUMO

High-voltage high-nickel low-cobalt lithium layered oxide cathodes show great application prospects for lithium-ion batteries due to their low cost and high capacity. However, deterioration of the bulk structure and the electrode-electrolyte interface will significantly endanger the cycle life and thermal stability of the battery as the nickel content and voltage increase. We present here a lattice doping strategy to greatly improve the cell performance by doping a small dose of Ti (2 mol %) in LiNi0.6Co0.05Mn0.35O2. Through density functional theory calculations, we know that the diffusion energy barrier of Li+ decreases and the activation energy of surface lattice oxygen atom loss increases after Ti doping, thereby improving the rate performance and inhibiting the undesired phase transition. The battery in situ X-ray diffraction (XRD) pattern demonstrates that Ti doping tunes the H1-H2 phase-transition process from a two-phase reaction to a single-phase reaction and inhibits the undesired H2-H3 phase transition, minimizing the mechanical degradation. The variable temperature in situ XRD reveals delayed phase-transition temperature to improve thermal stability. These improvements can be attributed to Ti doping to passivate the reactivity of the layered oxide cathode, which is fundamentally related to the strong Ti-O bond and no unpaired electrons for Ti4+. This work provides valuable strategic guidelines for the use of high-voltage high-nickel low-cobalt cathodes in lithium-ion batteries.

6.
Org Lett ; 23(22): 8688-8693, 2021 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-34755510

RESUMO

Palladium-catalyzed C2-arylation/intramolecular acylation with arylcarboxylic acids was developed by using diaryliodonium salts. The protocol has the advantage of good step-economy by two chemical bonds formation in one pot.

7.
BMC Musculoskelet Disord ; 22(1): 931, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34749698

RESUMO

BACKGROUND: The use of a tourniquet during high tibial osteotomy (HTO) is a routine procedure, but there is currently no research on the benefits and potential risks of tourniquet use during HTO. The aim of this study was to investigate the impact of tourniquet on perioperative blood loss, early functional recovery and complications in opening wedge HTO with modern tranexamic acid protocols. METHODS: This was a retrospective cohort study of patients who underwent unilateral opening wedge HTO between January 2019 and September 2020. All patients were divided into two groups according to whether a tourniquet was applied during HTO. Patients in both groups received the same surgical procedures, tranexamic acid protocols and other perioperative treatments. Preoperative baseline data, intraoperative data, early postoperative recovery and all complications during the 3-month follow-up were collected and compared between the two groups. RESULTS: A total of 62 patients were enrolled in this study, including 32 in the tourniquet group and 30 in the non-tourniquet group. There was no significant difference in preoperative baseline data between the two groups (P > 0.05 in all). Intraoperative blood loss in the tourniquet group was significantly lower than that in the non-tourniquet group (80.22 ml versus 94.00 ml, P < 0.001), but there was no difference in total blood loss (187.39 ml versus 193.31 ml, P = 0.714). And no patient in either group required blood transfusion. In terms of early postoperative recovery, tourniquet use significantly increased pain scores and reduced knee range of motion on the first and second postoperative days, but there was no significant difference between the two groups at postoperative third day and third month. Furthermore, there was no significant difference between the two groups in terms of lower limb force line correction, length of stay, Knee Society Score or the incidence of complications during the 3-month follow-up (P > 0.05 in all). CONCLUSIONS: In opening wedge HTO with modern tranexamic acid protocols, not using a tourniquet does not increase perioperative total blood loss or the risk of complications, but facilitates early postoperative recovery by reducing pain and increasing range of motion.


Assuntos
Osteoartrite do Joelho , Ácido Tranexâmico , Humanos , Osteotomia , Estudos Retrospectivos , Tíbia/diagnóstico por imagem , Tíbia/cirurgia , Torniquetes , Ácido Tranexâmico/efeitos adversos
8.
Molecules ; 26(21)2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34770854

RESUMO

Lactic acid (LA) is an important organic acid with broad industrial applications. Considered as an environmentally friendly alternative to petroleum-based plastic with a wide range of applications, polylactic acid has generated a great deal of interest and therefore the demand for optically pure l- or d-lactic acid has increased accordingly. Microbial fermentation is the industrial route for LA production. LA bacteria and certain genetic engineering bacteria are widely used for LA production. Although some fungi, such as Saccharomyces cerevisiae, are not natural LA producers, they have recently received increased attention for LA production because of their acid tolerance. The main challenge for LA bioproduction is the high cost of substrates. The development of LA production from cost-effective biomasses is a potential solution to reduce the cost of LA production. This review examined and discussed recent progress in optically pure l-lactic acid and optically pure d-lactic acid fermentation. The utilization of inexpensive substrates is also focused on. Additionally, for PLA production, a complete biological process by one-step fermentation from renewable resources is also currently being developed by metabolically engineered bacteria. We also summarize the strategies and procedures for metabolically engineering microorganisms producing PLA. In addition, there exists some challenges to efficiently produce PLA, therefore strategies to overcome these challenges through metabolic engineering combined with enzyme engineering are also discussed.

9.
Plant J ; 2021 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-34775642

RESUMO

Pollen tube integrity, growth, and guidance are crucial factors in plant sexual reproduction. Members of the plant Skewed5 (SKU5) Similar (SKS) family show strong similarity to multicopper oxidases (MCOs), but they lack conserved histidines in MCO active sites. The functions of most SKS family members are unknown. Here, we show that Arabidopsis pollen-expressed SKS11 and SKS12 play important roles in pollen tube integrity, growth, and guidance. The sks11sks12 mutant exhibited significantly reduced male fertility. Most of the pollen from sks11sks12 plants burst when germinated, and the pollen tubes grew slowly and exhibited defective growth along the funiculus and micropyle. SKS11-GFP and SKS12-mCherry were detected at the cell wall in pollen tubes. The contents of several cell wall polysaccharides and arabinogalactans were decreased in the pollen tube cell walls of sks11sks12 plants. Staining with a reactive oxygen species (ROS)-sensitive dye and use of the H2 O2 sensor HyPer revealed that the ROS content in the pollen tubes of sks11sks12 plants was remarkably reduced. SKS11444His-Ala , in which the last conserved histidine was mutated, could restore the mutant phenotypes of sks11sks12. Thus, SKS11/12 are required for pollen tube integrity, growth, and guidance possibly by regulating the ROS level and cell wall polysaccharide deposition or remodeling in pollen tubes.

10.
Mol Plant Pathol ; 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34741560

RESUMO

The hemibiotrophic pathogen Bipolaris sorokiniana causes root rot, leaf blotching, and black embryos in wheat and barley worldwide, resulting in significant yield and quality reductions. However, the mechanism underlying the host-pathogen interactions between B. sorokiniana and wheat or barley remains unknown. The B. sorokiniana genome encodes a large number of uncharacterized putative effector proteins. In this study, we identified a putative secreted protein, CsSp1, with a classic N-terminal signal peptide, that is induced during early infection. A split-marker approach was used to knock out CsSP1 in the Lankao 9-3 strain. Compared with the wild type, the deletion mutant ∆Cssp1 displayed less radial growth on potato dextrose agar plates and produced fewer spores, and complementary transformation completely restored the phenotype of the deletion mutant to that of the wild type. The pathogenicity of the deletion mutant in wheat was attenuated even though appressoria still penetrated the host. Additionally, the infectious hyphae in the deletion mutant became swollen and exhibited reduced growth in plant cells. The signal peptide of CsSp1 was functionally verified through a yeast YTK12 secretion system. Transient expression of CsSp1 in Nicotiana benthamiana inhibited lesion formation caused by Phytophthora capsici. Moreover, CsSp1 localized in the nucleus and cytoplasm of plant cells. In B. sorokiniana-infected wheat leaves, the salicylic acid-regulated genes TaPAL, TaPR1, and TaPR2 were down-regulated in the ∆Cssp1 strain compared with the wild-type strain under the same conditions. Therefore, CsSp1 is a virulence effector and is involved in triggering host immunity.

11.
Avian Res ; 12(1): 59, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34745642

RESUMO

Plastic waste and debris have caused substantial environmental pollution globally in the past decades, and they have been accumulated in hundreds of terrestrial and aquatic avian species. Birds are susceptible and vulnerable to external environments; therefore, they could be used to estimate the negative effects of environmental pollution. In this review, we summarize the effects of macroplastics, microplastics, and plastic-derived additives and plastic-absorbed chemicals on birds. First, macroplastics and microplastics accumulate in different tissues of various aquatic and terrestrial birds, suggesting that birds could suffer from the macroplastics and microplastics-associated contaminants in the aquatic and terrestrial environments. Second, the detrimental effects of macroplastics and microplastics, and their derived additives and absorbed chemicals on the individual survival, growth and development, reproductive output, and physiology, are summarized in different birds, as well as the known toxicological mechanisms of plastics in laboratory model mammals. Finally, we identify that human commensal birds, long-life-span birds, and model bird species could be utilized to different research objectives to evaluate plastic pollution burden and toxicological effects of chronic plastic exposure.

12.
Biochem Genet ; 2021 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-34802110

RESUMO

Members of the auxin/indoleacetic acid (Aux/IAA) gene family in plants are primary auxin-responsive genes that play important roles in many aspects of plant development and in responses to abiotic stress. Recently, 33 Aux/IAA have been identified in the apple genome. The biological responses of MdIAAs to salt stress are still unknown. In this study, Malus zumi, Malus baccata, and Malus × domestica 'Fuji' plantlets were subjected to salt stress by supplementing hydroponic media with NaCl at various concentrations. M. zumi showed the strongest salt resistance, followed by 'Fuji', and M. baccata was the most sensitive to salt stress. Tissue-specific expression profiles of MdIAAs were determined by quantitative real-time polymerase chain reaction. When apple plantlets were subjected to salt stress, most of salt-responsive MdIAAs were up-regulated by 1 h, 3 h, and 6 h in roots, shoot tips, and leaves, respectively. Highly expressed MdIAAs in roots, especially for M. zumi, consisted with the salt tolerance of apple rootstocks. Transgenic apple calli were tolerant to salt stress when over-expressed salt-responsive genes, MdIAA8, -9, and -25. These results provide clues about salt resistance in these three Malus species, which helps apple breeding of salt tolerance by genetic transformation.

13.
Can J Microbiol ; 67(12): 864-874, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34643413

RESUMO

Microbes play vital roles in soil quality; however, their response to N (nitrogen) and P (phosphorus) fertilization in acidic paddy soils of subtropical China remains poorly understood. Here, a 10-year field experiment was conducted to evaluate the effects of different fertilization treatments on microbial communities by Illumina MiSeq sequencing. The results showed that different fertilization treatments did not exert a significant effect on microbial alpha diversity, but altered soil properties, and thus affected microbial community composition. The microbial communities in the T1 (optimized N and P fertilizer) and T2 (excessive N fertilizer) treated soils differed from those in the T0 (no N and P fertilizer) and T3 (excessive P fertilizer) treated soils. In addition, the bacterial phyla Proteobacteria, Chloroflexi, and Acidobacteria, and the fungal phyla Ascomycota and Basidiomycota dominated all the fertilized treatments. Soil total potassium (TK) concentration was the most important factor driving the variation in bacterial community structure under different fertilization regimes, while the major factors shaping fungal community structure were soil TN and NO3--N (nitrate N). These findings indicate that optimization of N and P application rates might result in variations in soil properties, which changed the microbial community structure in the present study.


Assuntos
Ascomicetos , Microbiota , Fertilização , Fertilizantes/análise , Nitrogênio , Solo , Microbiologia do Solo
14.
China CDC Wkly ; 3(13): 267-273, 2021 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-34594864

RESUMO

What is already known about this topic?: Breast cancer is the most common cancer in women in China and around the world. By 2019, 121 countries have instituted a national screening program as a secondary prevention measure for breast cancer. What is added by this report?: Breast cancer screening rates in China were 18.9% in women aged 20 years and above, and 25.7% in women aged 35-64 years in 2015. The screening rate for women aged 20 years and above was significantly higher in urban areas than in rural areas (24.6% vs. 15.0%), and in the eastern region than in the central and western regions (24.0% vs. 15.1% and 15.3%). What are the implications for public health practice?: Continued efforts should be made to strengthen national and local policy initiatives and financial support for population-based, organized screening programs for breast cancer. Health education and accessibility of screening services to women across the country should be strengthened, especially for women aged 50 years and above.

15.
Ann Palliat Med ; 10(9): 9692-9701, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34628895

RESUMO

BACKGROUND: Gestational diabetes mellitus (GDM) increases the incidence of adverse outcomes in pregnant women. Individual diet intervention (IDI) was developed in our center through collaboration with nutritionists to treat GDM and prevent further complications. We then aimed to analyze the effects of IDI on the level of blood glucose and pregnancy outcomes in pregnant women with GDM. METHODS: We retrospectively enrolled pregnant women with GDM between April 2016 and March 2020. Participants in the control group received routine GDM care, and those in the study group received extra IDI on the basis of routine GDM care. Demographic and clinical characteristics of participating pregnant women were retrospectively collected. The study outcomes were the status of blood glucose control after 6 weeks of IDI or conventional intervention and pregnancy outcomes. Univariable and multivariable logistic regression analyses were sequentially performed to determine the predictors of proper blood glucose control and risk factors of adverse pregnancy outcomes in the study population. RESULTS: A total of 817 pregnant women who had been diagnosed as GDM were enrolled in this study, including 435 admitted between April 2016 to March 2018 who received conventional medication and 382 who were admitted between April 2018 to March 2020 and received IDI. Generally, there was no significant difference in baseline characteristics between study and control groups. Glycated hemoglobin (HbA1c) level after intervention was statistically lower in the study group than in the control group (5.6±0.9 vs. 5.5±0.7, P=0.006). Multivariable logistic regression analysis revealed that IDI was a predictor of proper blood glucose control in GDM participants (P=0.003). There were more cesarean sections and cases of macrosomia in the control group than the study group, showing statistical difference (35.9% vs. 28.5%, P=0.026; 8.7% vs. 4.7%, P=0.023, respectively). According to multivariable logistic regression analysis, IDI was identified as playing a protective role against cesarean section in GDM participants (P=0.034) and it could reduce the incidence of macrosomia in GDM participants (P=0.028). CONCLUSIONS: This novel pattern of IDI may not only help stabilize blood glucose levels in pregnant women with GDM, but also reduce the incidence of adverse outcomes to a certain extent.


Assuntos
Diabetes Gestacional , Glicemia , Cesárea , Feminino , Teste de Tolerância a Glucose , Humanos , Gravidez , Resultado da Gravidez , Estudos Retrospectivos
16.
Medicine (Baltimore) ; 100(37): e27221, 2021 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-34664860

RESUMO

BACKGROUND: Anemia is one of the most common manifestations in patients with cancer. Recently, multiple studies have shown a positive correlation between pretreatment anemia and tumor prognosis. Yet, the relationship between pretreatment anemia and the prognosis of soft tissue sarcomas (STS) is unclear. METHODS: We searched the PubMed and EMBASE databases to identify relevant studies. Eligible studies were included according to the inclusion criteria to assess the relationship between pretreatment anemia and the prognosis of patients with STS. Prognostic significance was determined by studying hazard ratios (HR) and 95% confidence intervals (CIs). RESULTS: A total of 12 studies are included. If there is significant heterogeneity, a random-effects model is used. Pooled data indicated that pretreatment anemia is related to poor overall survival (HR = 2.13; 95%CI = 1.52-2.98), disease-specific survival (HR = 1.53; 95%CI = 1.20-1.96), and disease-free survival (HR = 1.55; 95%CI = 1.10-2.17). The results of the subgroup analysis also support this conclusion. CONCLUSION: Our results suggest that pretreatment anemia may be a prognostic biomarker for STS.


Assuntos
Anemia/diagnóstico , Prognóstico , Sarcoma/complicações , Anemia/etiologia , Humanos
17.
Org Lett ; 23(20): 8056-8061, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34609885

RESUMO

An acid-mediated rapid synthesis of α-aryl azahelicenes via C-C bond cleavage of helical 9H-fluoren-9-ols is reported. The newly introduced aryl ring and pyridine moieties provide an excellent opportunity to further tune the properties of azahelicences: i.e., photoluminescence. The novel α-aryl azahelicenes showcase high circularly polarized luminescence (CPL) efficiencies (4.5 × 10-3) as well as CPL brightness (BCPL), reaching 7.39 M-1 cm-1, which indicates a potential application as chiral emitters.

18.
Pathobiology ; 88(6): 383-391, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34500447

RESUMO

INTRODUCTION: The aim of this study was to study the relationship between the formation of gastric fundic gland polyp and gastric hyperplastic polyp (HP) and the changes of gastric juice microenvironment. METHODS: The proton-pump inhibitor (PPI) applications to patients were recorded. Gastric juices and biopsy polyps were collected for pathological examination, H. pylori tests, biomarkers, and MUC1, MUC2, MUC5AC expression measurement. RESULTS: Among 34,892 patients, the detection rate of gastric fundic gland polyps was significantly higher than that of gastric HPs (p < 0.01). The incidence rate of gastric fundic gland polyp and gastric HP in PPI users (n = 3,886) was higher than that of non-PPI users (p < 0.01). The occurrence of polyp was positively related to the duration of PPI application and the H. pylori-positive rate. The bile reflux rate between fundic gland polys group (17.61%) and HPs (28.67%) was significantly different (p < 0.01). The levels of gastric juice Gastrin-17, epidermal growth factor (EGF) and MUC2 from patients with gastric fundic gland polyps and gastric HPs were higher than those in the control group (p < 0.01). However, patients with gastric fundic gland polyps and HPs had significantly lower gastric juice PGE2 and MUC5AC (p < 0.01). CONCLUSION: PPI application, H. pylori infection, and bile reflux are the potential risk factors for formation of fundic gland polyps and HPs. The potential mechanism of polyps' formation can be related to the levels of Gastrin-17, EGF, MUC2, PGE2, and MUC5AC in gastric juice.

19.
Front Aging Neurosci ; 13: 709998, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34489679

RESUMO

Background: Abnormal spontaneous neural activity is often found in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). However, the frequency dependence of neuronal interaction activities, especially the fractional amplitude of low-frequency fluctuation (fALFF) and degree centrality (DC), in PD-MCI is still unclear. Thus, this study aimed to explore the frequency dependence of PD-MCI based on fALFF and DC maps. Methods: Twenty-four patients with PD-MCI, 42 PD patients with normal cognition (PD-NC), and 33 healthy controls (HCs) were enrolled. Neuropsychological assessments and resting-state functional MRI (rs-fMRI) were performed. The fALFF and DC values in the conventional, slow4 and slow5 frequency bands were compared among the groups. Results: In the conventional frequency band, the DC value in the left precentral area was decreased in PD-MCI patients, while that in the right fusiform area was increased in PD-NC patients compared with HCs. Regarding fALFFs, both the PD-MCI and PD-NC patients had decreased values in the right precentral area compared with those of the HCs. The fALFFs did not differ between PD-MCI and PD-NC patients. The fALFF results in the slow4 subfrequency band were consistent with those in the conventional frequency band. In the slow5 band, the DC value in the left middle temporal lobe was higher in PD-MCI patients than in PD-NC patients and was positively correlated with the performance of the PD-MCI patients on the Montreal Cognitive Assessment (MoCA). Additionally, both PD-MCI and PD-NC patients showed lower fALFF values in the bilateral putamen than the HCs, and the fALFF in the bilateral putamen was negatively correlated with the Hoehn and Yahr stages of PD-MCI. The fALFF in the left putamen was negatively correlated with the scores of PD-MCI patients on the Movement Disorder Society-Unified Parkinson Disease Rating Scale Part III (MDS-UPRDS-III). Conclusion: Our results suggested that abnormal neuronal activities, such as fALFF and DC, are dependent on frequency in PD-MCI. Some subfrequency bands could distinguish PD-MCI from PD. Our findings may be helpful for further revealing the frequency-dependent resting functional disruption in PD-MCI.

20.
Org Biomol Chem ; 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34553205

RESUMO

The Lewis acid-promoted self-condensation of 2-indolylmethanols has been revealed. On treatment with La(OTf)3, highly substituted indeno[1,2-b]indole derivatives have been synthesized by using easily accessible 2-indolylmethanols with up to 94% yields. The utility of this method is further highlighted by evaluating the initial photophysical properties of some prepared products, indicating that the protocol may have potential applications in the construction of novel fluorescent materials.

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