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1.
Food Chem ; 368: 130687, 2022 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-34416486

RESUMO

The solubility and physicochemical properties of resveratrol in peanut oil were systematically studied following ultrasonic and magnetic stirring-assisted dissolution. The highest resveratrol solubility in peanut oil observed was 95.91%. The optimal dissolution process was determined to be the addition of 183.00 mg/kg resveratrol, a magnetic temperature of 40.00℃, and a magnetic duration of 3.50 h, which yielded a resveratrol content of 175.51 mg/kg oil. Under this standardized process, the oil composition remained unchanged. Resveratrol promoted the conversion of saturated triglycerides into unsaturated triglycerides, increased the linolenic acid content, and did not facilitate the formation of trans fatty acids. In addition, resveratrol preservedthe lightcolor, decreased the peroxide and acid values by 30%, prolonged the shelf life by more than 2 folds, and improved the thermal stability. In this sense, peanut oil with resveratrol can serve as anti-isomerism and antioxidant additive.


Assuntos
Antioxidantes , Óleo de Amendoim , Resveratrol , Solubilidade , Triglicerídeos
2.
Food Chem ; 369: 130915, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34496318

RESUMO

Commercial enzymatic pretreatment is being classically used for enhancing the oil extraction yield in the olive oil industry in China. Nevertheless, the mechanism is not yet clearly defined. The aim was to study the action of pectinase and cellulase for improving the oil yield from the aspects of oil droplets coalescence and rheological properties changes of olive paste during malaxation process. From confocal laser scanning microscopy imaging, the bound oil droplets were released and gradually coalesced into larger droplets, eventually formed a continuous oil phase with enzymatic pretreatment. Furthermore, the mixed enzymatic pretreatment effectively decreased viscosity of the olive pastes and promoted the depolymerization and solubilization of pectic polymers involved in the cell-cell adhesion, thus further enhanced the oil extraction yield from 7.15 % to 11.68 % (w/w). Finally, the mixed enzymatic pretreatment improved the droplet release and coalescence, reduced the viscosity of olive paste, and increased the oil yield.


Assuntos
Celulase , Poligalacturonase , Azeite de Oliva , Reologia , Viscosidade
3.
J Colloid Interface Sci ; 606(Pt 1): 38-46, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34384964

RESUMO

The rational design and use of highly efficient, economic, and environmentally friendly bifunctional catalysts for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is important for developing methods for overall water splitting. Here, we report a facile self-catalyzed growth strategy for in situ encapsulation of Co nanoparticles with N-doped carbon nanotubes (NCNTs) on Ni foam (NF) (Co/NCNTs-NF-T; T represents the pyrolysis temperature). The zeolite imidazole framework (ZIF-67) precursor, which was used as a structure inducer, provided a Co source for catalyzing melamine graphitization and promoted in situ growth of NCNTs on the NF surface. This encapsulation structure and self-supporting system enhance the HER and OER activities of Co/NCNTs-NF-900 (low overpotentials of 66.98 mV for the HER and 240.32 mV for the OER at 10 mA cm-2). This binder-free catalyst for overall water splitting, i.e., Co/NCNTs-NF-900, has excellent catalytic activity and durability. This method offers a facile and green strategy for designing highly active bifunctional electrocatalysts and paves the way for the future development of energy conversion/storage systems.

4.
Methods Mol Biol ; 2391: 75-87, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34686978

RESUMO

Characterization of a gene of interest frequently relies on generation of a mutant as a critical component. Transformation to disrupt a gene has been previously accomplished by several methods in Fusarium oxysporum. Here we provide a detailed method to generate a gene mutation mediated by a CRISPR/Cas9 ribonucleoprotein (RNP) complex. The Cas9 RNP cleaves the DNA at the target site, and during DNA repair integration of a dominant selectable marker is incorporated via homologous recombination generating the desired gene disruption.

5.
Methods Mol Biol ; 2391: 89-98, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34686979

RESUMO

F. oxysporum is a notorious filamentous pathogenic fungus that causes serious problems in agriculture and animal/human health. Knowing how the fungus interacts throughout the course of an infection is necessary to propose an effective control strategy, and consequently the manipulation of the F. oxysporum genome is essential to investigate the molecular interplay between the host and fungus. To facilitate assessing protein quantification and subcellular localization, we developed a simple, economical CRISPR/Cas9-mediated endogenous gene tagging (EGT) system based on two different strategies, homology-independent targeted integration (HITI) and homology-dependent recombination integration (HDRI). Reporter genes, including GFP and LacZ, can be inserted at the N- or C-terminus of an endogenous gene of interest at the original chromosomal locus, allowing partial characterization of the gene function.

6.
Environ Pollut ; 292(Pt B): 118399, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34695515

RESUMO

Evidence suggests that the invasion of Spartina alterniflora (S. alterniflora) poses potentially serious risks to the stability of coastal wetlands, an ecosystem that is extremely vulnerable to both biological and non-biological threats. However, the effects and mechanisms of sulfur (S) in mediating the growth and expansion of S. alterniflora are poorly understood, particularly when sediments are contaminated with cadmium (Cd). A 6-month greenhouse study was conducted to evaluate the mediating effect of S on Cd tolerance and growth of S. alterniflora. Treatments consisted of a factorial combination of three S rates (applied as Na2SO4; 0, 500, 1000 mg kg-1 dry weight (DW), as S0, S500, and S1000) and four Cd rates (applied as CdCl2; 0, 1, 2, 4 mg kg-1 DW, as Cd0, Cd1, Cd2, and Cd4). Results showed that although the exogenous S supply obviously increased Cd accumulation in roots (up to 71.22 ± 6.43 mg kg-1 DW) due to the decrease of Fe concentration in iron plaque (down to 4.02 ± 1.18 mg g-1 DW), biomass reduction and oxidative stress in plant tissues were significantly alleviated. The addition of S significantly up-regulated the concentration of compounds related to Cd tolerance, including proline and glutathione. Therefore, the translocation of Cd was restricted, and plant growth was not impacted. The present study demonstrated that the exogenous sulfur supply could promote the growth of S. alterniflora and enhance its tolerance to Cd. Therefore, under the effects of S. alterniflora, the increased fluctuations of S pool caused by the release and deposition of S might further exacerbate S. alterniflora expansion in Cd contaminated coastal wetlands.


Assuntos
Cádmio , Áreas Alagadas , Cádmio/toxicidade , China , Ecossistema , Espécies Introduzidas , Poaceae , Enxofre
7.
Sci Total Environ ; 806(Pt 4): 151374, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34740658

RESUMO

In this study, we empirically developed a robust model (the Root Mean Square Error (RMSE), bias, NSE and RE were 26.63 mg/L, -4.86 mg/L, 0.47 and 16.47%, respectively) for estimating the total suspended solids (TSS) concentrations in lakes and reservoirs (Hereinafter referred to as lakes) across the Eastern Plain Lake (EPL) Zone. The model was based on 700 in-situ TSS samples collected during 2007-2020 and logarithmic transformed red band reflectance of Landsat data. Based on the Google Earth Engine (GEE), the TSS concentrations in 16,804 lakes were mapped from 1984 to 2019. The results demonstrated a decreasing tendency of TSS in 82.2% of the examined lakes (72.5% of the basins) indicating that the pollutants carried by TSS flowing into the lakes were decreasing. Statistically significant variation (p < 0.05) was found in half of these lakes (28.6% of the basins). High TSS level (>100 mg/L) was observed in 0.31% of lakes (1.1% of the basins). The changing rates of TSS in 47.8% of the lakes (52.7% of the basins) ranged between -50 mg/L/yr and 0. We found high and significantly increased relative spatial heterogeneity of TSS in 4.6% and 6.5% of lakes, respectively. Likewise, the environmental factors, i.e., fertilizer usage, domestic wastewater, industrial wastewater, precipitation, wind speed and Normalized Difference Vegetation Index (NDVI) exhibited a significant correlation with interannual TSS in 38, 21, 20, 11, 17 and 15 of the 91 basins, respectively. This analysis indicated that only precipitation and fertilizer usage were significantly (p < 0.05) related to the spatial distribution of TSS. The relative contributions of the six factors to the interannual TSS changes were varied in different basins. Overall, the NDVI (the representation of vegetation cover) had a high mean contribution to the interannual TSS changes with an average contribution of 7.2%, and contributions of fertilizer were varied greatly among the basins (0.01%-68%). Human activities (fertilizer usage, domestic wastewater, industrial wastewater) and natural factors (precipitation, wind speed and NDVI) played relatively important roles to TSS changes in 14 and 15 of the 91 basins, respectively. Beyond the six factors in this study, other unanalyzed factors (such as lake depth and soil texture) also had some impacts on the distribution of TSS in the study area.

8.
Environ Pollut ; : 118577, 2021 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-34848291

RESUMO

Glomalin-related soil protein (GRSP) has received extensive attention due to its ability to immobilize metals in the environment. However, whether it can enter the food chain through digestion is still unclear. Mangroves occupy the transition zone between the sea and land, have important ecological functions. Mangroves suffer from fragmentation due to human activities and urbanization. A variety of waterfowls inhabit near the mangroves and ingest sediment settled on their food inadvertently or for grit; therefore, they are ideal for revealing GRSP's role in metal enrichment. In this study, we investigated the release of metals from mangrove surface sediments and GRSP through a physiologically based extraction test. The investigated metals (As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Zn) in sediments and those bound to GRSP would be mainly released in the gizzard phase. GRSP appeared to be an efficient carrier of Cu, Zn, Pb, and As from sediments to the waterfowls via direct sediment ingestion. For instance, 3.21% and 3.34% of sediment Cu were released in the gizzard and intestinal phases, respectively, meanwhile GRSP-bound Cu contributed 5.04% and 5.42% to this flux. The continuum of GRSP enrichment - complexation of GRSP and metals - biological accessiblity of GRSP-bound metals, influenced by both direct and indirect effects from major nutrients (e.g., C, N, P, and S) and metal contents (e.g., Cu, Cd, Ni), controlled the release of GRSP-bound metals during simulated digestion. Overall, this study provides new insights into the potential risk of GRSP acting as a metal delivery vehicle in the food chain.

9.
Free Radic Biol Med ; 2021 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-34848368

RESUMO

Insulin resistance (IR) promotes atherosclerosis and increases the risk of diabetes and cardiovascular diseases. Our previous studies have demonstrated that high uric acid (HUA) increased oxidative stress, leading to IR in cardiomyocytes and pancreatic ß cells. However, whether HUA can induce IR in monocytes/macrophages, which play critical roles in all stages of atherosclerosis, is unclear. Recent findings revealed that thioredoxin-interacting protein (TXNIP) negatively regulates insulin signaling; however, the roles and mechanisms of TXNIP in HUA-induced IR remain unclear. Therefore, in this study, we investigated the function of TXNIP in macrophages treated with UA. Transcriptomic profiling revealed TXNIP as one of the most upregulated genes, and subsequent RT-PCR and western blot analyses confirmed that TXNIP was upregulated by HUA. HUA treatment significantly increased mitochondrial reactive oxygen species (MtROS) levels and decreased insulin-stimulated glucose uptake. Silencing TXNIP by RNA interference significantly diminished HUA-induced oxidative stress and IR. Mechanistically, silencing TXNIP reversed the inhibition of the phosphorylation of insulin receptor substrate 2 (IRS2)/protein kinase B (AKT) pathway induced by HUA. Additional study revealed that HUA induced the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) signaling pathway, but silencing TXNIP abolished it. Moreover, Nrf2 inhibitor (ML385) ameliorated HUA-induced IR independent of IRS2/AKT signaling. Probenecid, a well-known UA-lowering drug, significantly suppressed the activation of TXNIP and Nrf2/HO-1 signaling. Furthermore, RNA-seq revealed that activation of the TXNIP-related redox pathway may be a key regulator in patients with asymptomatic hyperuricemia. These data suggest that silencing TXNIP could ameliorate HUA-induced IR via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. Additionally, TXNIP might be a promising therapeutic target for preventing and treating oxidative stress and IR induced by HUA.

11.
Adv Mater ; : e2106677, 2021 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-34729827

RESUMO

The optimization of MgO-based adsorbents as advanced CO2 capture materials is predominantly focused on their molten salt modification for which theoretical and experimental contributions provide great insights for their high CO2 -capture performance. The underlying mechanism of the promotion effect of the molten salt on CO2 capture, however, is a topic of controversy among several theoretical approaches. Herein, advanced experimental characterization techniques, including in situ eTEM, in situ CO2 -DRIFTS, transient 18 O-isotopic exchange, and Density Functional Theory are employed to elucidate the mechanism of CO2 interaction with molten salt-modified MgO in the 250-400 °C range. Herein, eTEM studies using low (2-3 mbar) and high (700 mbar) CO2 pressures illustrate the dynamic evolution of the molten NaNO3 salt-promoted and unpromoted MgO carbonation with high magnification (< 50 nm). The formation of 18 O-NaNO3 (use of 18 O2 ), and that of C16 O18 O following CO2 interaction, verifies for the first time the proposed theoretical (DFT) reaction path: Conversion of NO3 - (NO3 - → NO2 + + O2- ), adsorption of NO2 + on MgO with significant weakening of CO2 adsorption strength, and formation of [Mg2+ … O2- ] ion pairs preventing the development of an impermeable MgCO3 shell, which largely increases the rate of bulk MgO carbonation compared to the unmodified MgO. This article is protected by copyright. All rights reserved.

13.
Adv Sci (Weinh) ; : e2102886, 2021 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-34719862

RESUMO

Electrochemical CO2 reduction to value-added chemicals/fuels provides a promising way to mitigate CO2 emission and alleviate energy shortage. CO2 -to-CO conversion involves only two-electron/proton transfer and thus is kinetically fast. Among the various developed CO2 -to-CO reduction electrocatalysts, transition metal/N-doped carbon (M-N-C) catalysts are attractive due to their low cost and high activity. In this work, recent progress on the development of M-N-C catalysts for electrochemical CO2 -to-CO conversion is reviewed in detail. The regulation of the active sites in M-N-C catalysts and their related adjustable electrocatalytic CO2 reduction performance is discussed. A visual performance comparison of M-N-C catalysts for CO2 reduction reaction (CO2 RR) reported over the recent years is given, which suggests that Ni and Fe-N-C catalysts are the most promising candidates for large-scale reduction of CO2 to produce CO. Finally, outlooks and challenges are proposed for future research of CO2 -to-CO conversion.

14.
Mol Nutr Food Res ; : e2100210, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34747100

RESUMO

SCOPE: Peanut stem and leaf (PSL), a traditional Chinese medicine, is widely used as a dietary supplement to improve sleep quality; however, the underlying mechanism is unclear. Here, the study aims to determine whether active compounds in PSL extract exert their effects by mediating neuronal excitability. METHODS AND RESULTS: Aqueous PSL extract (500 mg kg-1 BW) increases the duration of total sleep (TS), slow wave sleep (SWS) and rapid eye movement sleep (REMS) in BALB/c mice after 7 and 14 continuous days of intragastric administration. Two PSL extract components with flavonoid-like structures: 4',7-di-O-methylnaringenin (DMN, 61 µg kg-1 BW) and 2'-O-methylisoliquiritigenin (MIL, 12 µg kg-1 BW), show similar effects on sleep in BALB/c mice. Moreover, incubation with DMN (50 µM) and MIL (50 µM) acutely reduces voltage-gated sodium and potassium currents and suppresses the firing of evoked action potential in mouse cortical neurons, indicating the inhibition on neuronal excitability. Meanwhile, RNA-seq analysis predicts the potential regulation of voltage-gated channels, which is according with the molecular docking simulation that both MIL and DMN can bind to voltage gated sodium channels 1.2 (Nav 1.2). CONCLUSIONS: DMN and MIL are the active ingredients of PSL that improve sleep quality, suggesting that PSL promotes sleep by regulating the excitability of neurons.

15.
Medicine (Baltimore) ; 100(46): e27195, 2021 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-34797271

RESUMO

BACKGROUND: Chronic pain is the most common disease in the world, which lead the patients to suffer the disability both physically and psychologically. The chronic pain can affects the patients to work, socialize, sleep and can lead to depressive illness, decreased motivation, and a reduction in physical activity. Acupuncture is a promising treatment for the chronic pain which has a long history of use in China. This protocol aims to assess the effectiveness and safety of touching periosteum acupuncture therapy on patients with chronic pain. METHODS: Randomized controlled trial literatures which include touching periosteum acupuncture therapy for treating chronic pain will be searched from 8 electronic databases including China Biology Medicine disc, VIP database, WanFang database, China National Knowledge Infrastructure, PubMed, Cochrane Library, Excerpt Medical Database, and Web of Science. The language will be restricted to Chinese and English. The primary outcome is to measure the relief of the pain by Visual Analogue Scale. Two or 3 reviewers will conduct the study selection, data extraction and the evaluation of the risk of bias. RevMan software (V.5.3) will be used to perform the assessment of the risk of bias and data synthesis. RESULTS: From this study, we will confirm the effectiveness of safety of in the treatment of chronic pain. CONCLUSIONS: We will ascertain the effectiveness of safety of touching periosteum acupuncture therapy in the treatment of chronic pain, to provide evidence to guide touching periosteum acupuncture therapy for patients with chronic pain in the future. ETHICS AND DISSEMINATION: Ethics approval will not be necessary, because the included publications in our study are all from published articles. This systematic review will be published in a peer-reviewed journal or conference report to provide a reference in this field. TRIAL REGISTRATION: CRD42021243387.

16.
Sensors (Basel) ; 21(21)2021 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-34770511

RESUMO

As an important part of urban rail transit, subway tunnels play an important role in alleviating traffic pressure in mega-cities. Identifying and locating damage to the tunnel structure as early as possible has important practical significance for maintaining the long-term safe operation of subway tunnels. Summarizing the current status and shortcomings of the structural health monitoring of subway tunnels, a very economical and effective monitoring program is proposed, which is to use the train vibration response to identify and locate the damage of the tunnel structure. Firstly, the control equation of vehicle-tunnel coupling vibration is established and its analytical solution is given as the theoretical basis of this paper. Then, a damage index based on the cumulative sum of wavelet packet energy change rate (TDISC) is proposed, and its process algorithm is given. Through the joint simulation of VI-Rail and ANSYS, a refined 3D train-tunnel coupled vibration model is established. In this model, different combined conditions of single damage and double damage verify the validity of the damage index. The effectiveness of this damage index was further verified through model tests, and the influence of vehicle speed and load on the algorithm was discussed. Numerical simulation and experimental results show that the TDISC can effectively locate the damage of the tunnel structure and has good robustness.


Assuntos
Ferrovias , Cidades , Vibração
17.
J Phys Chem B ; 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34788045

RESUMO

Here, we report a new state-diagram for aqueous solutions based on concentration-dependent glass-transition temperatures of concentrated and ice freeze-concentrated solutions. Different from the equilibrium phase diagram, this new state-diagram can provide comprehensive information about the hydration numbers of solutes, nonequilibrium vitrification/cold-crystallization, and vitrification/devitrification processes of aqueous solutions in three distinct concentration zones separated by two critical water-content points of only functions of the hydration number. Based on this new state-diagram, we observe the comparable hydration ability of LiTFSI to LiCl and an atypical concentration-dependent cold-crystallization behavior of the LiTFSI-H2O system. These results unveil the negligible hydration ability of TFSI- in a water-rich solution, characterize the antiplasticizing effect of water induced by the strengthened Li+-TFSI--H2O interaction when only hydration water and confined water are present, and confirm the increasing fraction of water-rich domains with the decrease in water content when the cation and anion become incompletely hydrated on average. These results highlight the novel water-content-mediated interactions among the anion, cation, and H2O for LiTFSI-H2O.

18.
BMC Cancer ; 21(1): 1229, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34784889

RESUMO

BACKGROUND: The optimal modality for postoperative analgesia after uniportal video-assisted thoracoscopic surgery (UVATS) for the treatment of lung cancer has not yet been determined. Both ultrasound-guided paravertebral block (PVB) and retrolaminar block (RLB) have been reported to be successful in providing analgesia after UVATS. However, which block technique provides superior analgesia after UVATS is still unclear. This randomized study was designed to compare the postoperative analgesic effects and adverse events associated with ultrasound-guided PVB and RLB after UVATS. METHODS: Sixty patients with lung cancer were randomized to undergo ultrasound-guided PVB (group P) or ultrasound-guided RLB (group R). In group P, 30 mL of 0.5% ropivacaine was injected at the T3 and T5 levels via ultrasound-guided PVB (15 mL at each level on the operative side). In group R, 30 mL of 0.5% ropivacaine was injected at the T3 and T5 levels via ultrasound-guided RLB (15 mL at each level on the operative side). The primary outcome was the numerical rating scale (NRS) score within 48 h after surgery. The secondary outcomes were total postoperative sufentanil consumption, time to first analgesic request and adverse events. RESULTS: At 3, 6, 12, 24, 36 and 48 h postoperatively, the NRS score at rest in group P was lower than that in group R (p < 0.05). At 3, 6, 12, 24 and 36 h postoperatively, the NRS score while coughing in group P was lower than that in group R (p < 0.05). The total postoperative sufentanil consumption in group P was significantly lower than that in group R (p < 0.001). Additionally, the time to first analgesic request was longer in group R than in group P (p < 0.0001). The incidence of nausea in group R was higher than that in group P (p < 0.05). CONCLUSIONS: In patients with lung cancer undergoing UVATS, ultrasound-guided PVB with 0.5% ropivacaine provides better analgesia and results in less nausea than ultrasound-guided RLB. Compared with ultrasound-guided RLB, ultrasound-guided PVB seems to be a better technique for analgesia in UVATS. TRIAL REGISTRATION: The name of this study is the Effect And Mechanism Of Ultrasound-guided Multimodal Regional Nerve Block On Acute And Chronic Pain After Thoracic Surgery. This study was registered in the Chinese Clinical Trial Registry ( ChiCTR2100044060 ). The date of registration was March 9, 2021.

19.
BMC Psychiatry ; 21(1): 574, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34784908

RESUMO

BACKGROUND: It is unclear whether psychotic experiences (PEs) gradually merge into states of clinical psychosis along a continuum which correspond to a dimensional classification or whether latent classes appear above a certain severity threshold which correspond better to diagnostic categories of psychosis. METHODS: Annual cross-sectional surveys, 2014-19, among Chinese undergraduates (N = 47,004) measured PEs, depression and etiological risk factors using standardized self-report instruments. We created a psychosis continuum with five levels and tested linear and extra-linear contrasts in associated etiological risk factors, before and after adjustment for depression. We carried out latent class analysis. RESULTS: Categorical expression of psychosis, including hallucinations and delusions, nuclear symptoms, and nuclear symptoms and depression were found at severe level 5. Etiological risk factors which impacted linearly across the continuum were more common for depression. Child maltreatment impacted extra-linearly on both psychosis and depression. Family history of psychosis impacted linearly on psychosis; male sex and urban birth impacted extra-linearly and were specific for psychosis. Four latent classes were found, but only at level 5. These corresponded to nuclear schizophrenia symptoms, nuclear schizophrenia and depressive symptoms, severe depression, and an unclassified category with moderate prevalence of PEs. CONCLUSION: Quantitative and qualitative changes in the underlying structure of psychosis were observed at the most severe level along a psychosis continuum, where four latent classes emerged. These corresponded to existing categorical classifications but require confirmation with clinical interview. PEs are non-specific and our findings suggest some are on a continuum with depression, whilst others are on a continuum with non-affective psychosis. Differing patterns of impact from etiological risk factors across the spectrum of psychopathology determine outcome at the most severe level of these continua.

20.
Front Psychiatry ; 12: 773338, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795602

RESUMO

Background: Although the relevant underlying biological mechanisms are still lacking, mental disorders have been closely associated with several metabolic abnormalities including high rates of obesity and metabolic syndrome especially in vulnerable populations. Therefore, the current study aims to examine how metabolic parameters increase the risk for developing mood disorders in individuals stratified by gender and age. Methods: In a routine physical examination, 319 healthy participants were recruited and assigned to six different groups according to age (young adults: 25-34 Y, middle age: 35-49 Y, and older age: 50-65 Y) in both males and females. A linear regression and bivariate correlation analysis were used to analyze the relationship between mood health outcomes measured by the Kessler 10 Psychological Distress Scale (K10) and the metabolic function. Results: The results demonstrated that there was a significant association between K10 scores and metabolic parameters, including Body Mass Index (BMI), total-, LDL-cholesterol, and triglyceride. Furthermore, poor mental health (higher K10 scores) was observed in individuals with increased BMI, total-, LDL-cholesterol, and triglyceride levels particularly in middle-aged women relative to other groups. Limitations: This is a cross-sectional study with a small sample size and lacks longitudinal follow-up evidence and preventive interventions and therefore could not provide the causal inference of metabolic pathophysiology on the increased sensitivity to mental disorders. Conclusions: The potential association suggests that targeting of the metabolic parameters might give us a better understanding of the underlying mechanisms of psychiatric diseases and provide preventive strategies and potential treatment for those with metabolic disturbances especially in middle-aged females.

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