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1.
Artigo em Inglês | MEDLINE | ID: mdl-38862798

RESUMO

Ammonia nitrogen (NH3-N/NH4+-N) serves as a crucial chemical in biochemistry and fertilizer synthesis. However, it is also a toxic compound, posing risks from eutrophication to direct threats to human health. Ammonia nitrogen pollution pervades water sources, presenting a significant challenge. While several water treatment technologies exist, biological treatment, though widely used, has its limitations. Hence, green and efficient photocatalytic technology emerges as a promising solution. However, current monolithic semiconductor photocatalysts prove inadequate in controlling ammonia nitrogen pollution. Therefore, this review focuses on enhancing semiconductor photocatalysts' efficiency through modification, discussing four mechanisms: (1) mono-ionic modification; (2) metallic and non-metallic modification; (3) construct heterojunctions; and (4) enhancement of synergistic effects of multiple technologies. The influencing factors of photocatalytic ammonia nitrogen removal efficiency are also explored. Moreover, the review outlines the limitations of current photocatalytic pollution treatment and discusses future development trends and research challenges. Currently, the main products of ammonia nitrogen removal include NO3-, NO2-, and N2. To mitigate secondary pollution, the green process of converting ammonia nitrogen to N2 using photocatalysis emerges as a fundamental approach for future treatment. Overall, this review aims to deepen understanding of photocatalysis in ammonia nitrogen treatment and guide researchers toward widespread implementation of this endeavor.

2.
Sci Total Environ ; 941: 173680, 2024 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-38844212

RESUMO

Microorganisms play a critical role in the biogeochemical cycling of selenium in natural ecosystems, particularly in reducing selenite (Se(IV)) to element selenium (Se(0)) which reduces its mobility and bioavailability. However, Se(IV)-reducing bacteria and their reducing characteristics in estuarine sediments remain inadequately understood. In this study, the reduction of Se(IV) was confirmed to be microbially driven through the cultivation of a mixture of estuarine sediment and Se(IV) under aerobic conditions. Community analysis indicates that Bacillus was primarily involved in the reduction of Se(IV). A strain with high salt tolerance (7.5 % NaCl) and Se(IV) resistance (up to 200 mM), Bacillus cereus SD1, was isolated from an estuarine sediment. The reduction of Se(IV) occurred concomitantly with the onset of microbial growth, and reduction capacity increased approximately 5-fold by adjusting the pH. In addition, Se(IV) reduction in Bacillus cereus SD1 was significantly inhibited by sulfite, and the key enzyme activity tests revealed the possible presence of a sulfite reductase-mediated Se(IV) reduction pathway. These research findings provide new insights into the bioreducing characteristics and the biogeochemical cycling of selenium in estuarine environments.

3.
J Hazard Mater ; 475: 134761, 2024 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-38870848

RESUMO

Dust pollution poses a grave threat to both the environment and human health, especially in mining operations. To combat this issue, a novel evaluation method is proposed, integrating grayscale average (GA) analysis and deep learning (DL) in image classification. By utilizing a self-designed dust diffusion simulation system, 300 sample images were generated for analysis. The GA method establishes a correlation between grayscale average and dust mass, while incorporating fractal dimension (FD) enhances classification criteria. Both GA and DL methods were trained and compared, yielding promising results with a testing accuracy of 92.2 % and high precision, recall, and F1-score values. This approach not only demonstrates efficacy in classifying dust pollution but also presents a versatile solution applicable beyond mining to diverse dust-contaminated work environments. By combining image processing and deep learning, it offers an automated and reliable system for environmental monitoring, thereby enhancing safety standards and health outcomes in affected industries. Ultimately, this innovative method signifies a significant advancement towards mitigating dust pollution and ensuring sustainable industrial practices.

4.
Signal Transduct Target Ther ; 9(1): 107, 2024 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-38697972

RESUMO

Cholangiocarcinoma (CCA) is a highly malignant biliary tract cancer with currently suboptimal diagnostic and prognostic approaches. We present a novel system to monitor CCA using exosomal circular RNA (circRNA) via serum and biliary liquid biopsies. A pilot cohort consisting of patients with CCA-induced biliary obstruction (CCA-BO, n = 5) and benign biliary obstruction (BBO, n = 5) was used to identify CCA-derived exosomal circRNAs through microarray analysis. This was followed by a discovery cohort (n = 20) to further reveal a CCA-specific circRNA complex (hsa-circ-0000367, hsa-circ-0021647, and hsa-circ-0000288) in both bile and serum exosomes. In vitro and in vivo studies revealed the three circRNAs as promoters of CCA invasiveness. Diagnostic and prognostic models were established and verified by two independent cohorts (training cohort, n = 184; validation cohort, n = 105). An interpreter-free diagnostic model disclosed the diagnostic power of biliary exosomal circRNA signature (Bile-DS, AUROC = 0.947, RR = 6.05) and serum exosomal circRNA signature (Serum-DS, AUROC = 0.861, RR = 4.04) compared with conventional CA19-9 (AUROC = 0.759, RR = 2.08). A prognostic model of CCA undergoing curative-intent surgery was established by calculating early recurrence score, verified with bile samples (Bile-ERS, C-index=0.783) and serum samples (Serum-ERS, C-index = 0.782). These models, combined with other prognostic factors revealed by COX-PH model, enabled the establishment of nomograms for recurrence monitoring of CCA. Our study demonstrates that the exosomal triple-circRNA panel identified in both bile and serum samples serves as a novel diagnostic and prognostic tool for the clinical management of CCA.


Assuntos
Colangiocarcinoma , Exossomos , RNA Circular , Humanos , RNA Circular/genética , RNA Circular/sangue , Colangiocarcinoma/genética , Colangiocarcinoma/diagnóstico , Colangiocarcinoma/sangue , Colangiocarcinoma/patologia , Exossomos/genética , Masculino , Feminino , Recidiva Local de Neoplasia/genética , Recidiva Local de Neoplasia/patologia , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/sangue , Pessoa de Meia-Idade , Neoplasias dos Ductos Biliares/genética , Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/sangue , Neoplasias dos Ductos Biliares/patologia , Prognóstico , Colestase/genética , Colestase/diagnóstico , Colestase/sangue
5.
Water Res ; 258: 121766, 2024 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-38759285

RESUMO

Microbially-mediated redox processes involving arsenic (As) and its host minerals significantly contribute to the mobilization of As in estuarine sediments. Despite its significance, the coupling between As dynamics and denitrification processes in these sediments is not well understood. This study employed sequential sediment extractions and simultaneous monitoring of dissolved iron (Fe), nitrogen (N), and sulfur (S) to investigate the impact of nitrate (NO3-) on the speciation and redistribution of As, alongside changes in microbial community composition. Our results indicated that NO3- additions significantly enhance anaerobic arsenite (As(III)) oxidation, facilitating its immobilization by increased adsorption onto sediment matrices in As-contaminated estuarine settings. Furthermore, NO3- promoted the conversion of As bound to troilite (FeS) and pyrite (FeS2) into forms associated with Fe oxides, challenging the previously assumed stability of FeS/FeS2-bound As in such environments. Continuous NO3- additions ensured As and Fe oxidation, thereby preventing their reductive dissolution and stabilizing the process that reduces As mobility. Changes in the abundance of bacterial communities and correlation analyses revealed that uncultured Anaerolineaceae and Thioalkalispira may be the main genus involved in these transformations. This study underscores the critical role of NO3- availability in modulating the biogeochemical cycle of As in estuarine sediments, offering profound insights for enhancing As immobilization techniques and informing environmental management and remediation strategies in As-contaminated coastal regions.

6.
Sci Total Environ ; 926: 172123, 2024 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-38575008

RESUMO

Arsenic (As) contamination in realgar mining areas poses a severe environmental and health risk, highlighting the critical need for effective strategies to manage As migration, particularly in its particulate and bioavailable states. Soil erosion and water leaching serve as significant pathways for spreading As, emphasizing the imperative to curtail its mobility. In the present study, we proposed an effective strategy that combines the utilization of polyacrylamide (PAM), nano-SiO2 (NS), and ferrihydrite (Fh) to elevate the stability of As in soils from a realgar mining area. The results show that this composite material demonstrates the capability to concurrently regulate soil erosion and mitigate the leaching of bioavailable As. The combination of the three materials in the proportion of 0.5 % PAM +0.1 % NS + 1.0 % Fh can reduce the soil particulate and bioavailable As content by 99.11 % and 93.98 %, respectively. The unconfined compressive strength of the soil can be increased by about 30 % under this condition. The SEM analyses show that the addition of PAM and NS can significantly enhance the aggregation of soil particles and then reduce the soil erosion rate. These findings highlight the significant potential of the proposed approach in mitigating As contamination in soil within mining environments. The approach offers a sustainable and comprehensive solution to address the transport of heavy metal contaminants in both particulate and bioavailable states in mining areas.

7.
Environ Sci Technol ; 58(16): 7176-7185, 2024 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-38606801

RESUMO

Hydrous ferric arsenate (HFA) is a common thermodynamically metastable phase in acid mine drainage (AMD). However, little is known regarding the structural forms and transformation mechanism of HFA. We investigated the local atomic structures and the crystallization transformation of HFA at various Fe(III)/As(V) ratios (2, 1, 0.5, 0.33, and 0.25) in acidic solutions (pH 1.2 and 1.8). The results show that the Fe(III)/As(V) in HFA decreases with decreasing initial Fe(III)/As(V) at acidic pHs. The degree of protonation of As(V) in HFA increases with increasing As(V) concentrations. The Fe K-edge extended X-ray absorption fine structure and X-ray absorption near-edge structure results reveal that each FeO6 is linked to more than two AsO4 in HFA precipitated at Fe(III)/As(V) < 1. Furthermore, the formation of scorodite (FeAsO4·2H2O) is greatly accelerated by decreasing the initial Fe(III)/As(V). The release of As(V) from HFA is observed during its crystallization transformation process to scorodite at Fe(III)/As(V) < 1, which is different from that at Fe(III)/As(V) ≥ 1. Scanning electron microscopy results show that Oswald ripening is responsible for the coarsening of scorodite regardless of the initial Fe(III)/As(V) or pH. Moreover, the formation of crystalline ferric dihydrogen arsenate as an intermediate phase at Fe(III)/As(V) < 1 is responsible for the enhanced transformation rate from HFA to scorodite. This work provides new insights into the local atomic structure of HFA and its crystallization transformation that may occur in AMD and has important implications for arsenic geochemical cycling.

8.
Nano Lett ; 24(20): 6192-6200, 2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38666542

RESUMO

Creating artificial synapses that can interact with biological neural systems is critical for developing advanced intelligent systems. However, there are still many difficulties, including device morphology and fluid selection. Based on Micro-Electro-Mechanical System technologies, we utilized two immiscible electrolytes to form a liquid/liquid interface at the tip of a funnel nanochannel, effectively enabling a wafer-level fabrication, interactions between multiple information carriers, and electron-to-chemical signal transitions. The distinctive ionic transport properties successfully achieved a hysteresis in ionic transport, resulting in adjustable multistage conductance gradient and synaptic functions. Notably, the device is similar to biological systems in terms of structure and signal carriers, especially for the low operating voltage (200 mV), which matches the biological neural potential (∼110 mV). This work lays the foundation for realizing the function of iontronics neuromorphic computing at ultralow operating voltages and in-memory computing, which can break the limits of information barriers for brain-machine interfaces.


Assuntos
Nanotecnologia , Sinapses , Sinapses/fisiologia , Nanotecnologia/instrumentação , Eletrólitos/química , Nanoestruturas/química , Neurônios/fisiologia , Condutividade Elétrica
9.
Sci Total Environ ; 928: 172134, 2024 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-38583612

RESUMO

Sediment-adsorbed Dissolved Organic Matter (SDOM) in coast plays a crucial role in the terrestrial and marine carbon cycle processes of the global environment. However, understanding the transport dynamics of SDOM along the coast of China, particularly its interactions with sediments, remains elusive. In this study, we analyzed the δ13C and δ15N stable isotopic compositions, as well as the molecular characteristics of SDOM collected from coastal areas spanning the Bohai Sea (BS), Yellow Sea (YS), East China Sea (ECS), and South China Sea (SCS), by using isotope ratio mass spectrometry and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS). We identified the predominant sources of carbon and nitrogen in coastal sediments, revealing terrigenous origins for most C and N, while anthropogenic sources dominated in the SCS. Spatial variations in SDOM chemodiversity were observed, with diverse molecular components influenced by distinct environmental factors and sediment sources. Notably, lignins and saturated compounds (such as proteins/amino sugars) were the predominant molecular compounds detected in coastal SDOM. Through Mantel tests and Spearman's correlation analysis, we elucidated the significant influence of spatial environmental factors (temperature, DO, salinity, and depth) and sediment sources on SDOM molecular chemodiversity. These findings contribute to a more comprehensive understanding of the carbon cycle dynamics along the Chinese coast.

10.
Future Microbiol ; 2024 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-38683167

RESUMO

Diverse microorganisms live as biofilm in the mouth accounts for oral diseases and treatment failure. For decades, the prevention and treatment of oral biofilm is a global challenge. Antimicrobial photodynamic therapy (aPDT) holds promise for oral biofilm elimination due to its several traits, including broad-spectrum antimicrobial capacity, lower possibility of resistance and low cytotoxicity. However, the physicochemical properties of photosensitizers and the biological barrier of oral biofilm have limited the efficiency of aPDT. Nanomaterials has been used to fabricate nanocarriers to improve photosensitizer properties and thus enhance antimicrobial effect. In this review, we have discussed the challenges of aPDT used in dentistry, categorized the nanomaterial-delivery system and listed the possible mechanisms involved in nanomaterials when enhancing aPDT effect.

11.
BMC Cancer ; 24(1): 426, 2024 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-38584263

RESUMO

BACKGROUND: Colorectal cancer (CRC) is the 3rd most common malignancy with the liver being the most common site of metastases. The recurrence rate of colorectal liver metastases (CRLM) after liver resection (LR) is notably high, with an estimated 40% of patients experiencing recurrence within 6 months. In this context, we conducted a meta-analysis to synthesize and evaluate the reliability of evidence pertaining to prognostic factors associated with early recurrence (ER) in CRLM following LR. METHODS: Systematic searches were conducted from the inception of databases to July 14, 2023, to identify studies reporting prognostic factors associated with ER. The Quality in Prognostic Factor Studies (QUIPS) tool was employed to assess risk-of-bias for included studies. Meta-analysis was then performed on these prognostic factors, summarized by forest plots. The grading of evidence was based on sample size, heterogeneity, and Egger's P value. RESULTS: The study included 24 investigations, comprising 12705 individuals, during an accrual period that extended from 2007 to 2023. In the evaluation of risk-of-bias, 22 studies were rated as low/moderate risk, while two studies were excluded because of high risk. Most of the studies used a postoperative interval of 6 months to define ER, with 30.2% (95% confidence interval [CI], 24.1-36.4%) of the patients experiencing ER following LR. 21 studies were pooled for meta-analysis. High-quality evidence showed that poor differentiation of CRC, larger and bilobar-distributed liver metastases, major hepatectomy, positive surgical margins, and postoperative complications were associated with an elevated risk of ER. Additionally, moderate-quality evidence suggested that elevated levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA199), lymph node metastases (LNM) of CRC, and a higher number of liver metastases were risk factors for ER. CONCLUSION: This review has the potential to enhance the efficacy of surveillance strategies, refine prognostic assessments, and guide judicious treatment decisions for CRLM patients with high risk of ER. Additionally, it is essential to undertake well-designed prospective investigations to examine additional prognostic factors and develop salvage therapeutic approaches for ER of CRLM.


Assuntos
Neoplasias Colorretais , Neoplasias Hepáticas , Humanos , Hepatectomia , Prognóstico , Neoplasias Colorretais/cirurgia , Neoplasias Colorretais/patologia , Estudos Prospectivos , Reprodutibilidade dos Testes , Neoplasias Hepáticas/patologia , Recidiva Local de Neoplasia/cirurgia , Estudos Retrospectivos
12.
Int Wound J ; 21(3): e14715, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38494179

RESUMO

To systematically explore the effects of minimally invasive plate osteosynthesis (MIPO) versus intramedullary nail (IMN) on wound infection and wound healing in patients with distal tibia fractures. A computerised search of PubMed, Web of Science, Cochrane Library, Embase, Wanfang, China Biomedical Literature Database (CBM) and China National Knowledge Infrastructure databases was performed, from their inception to October 2023, to identify relevant studies on the application of MIPO and IMN in patients with distal tibial fractures. The quality of the included literature was evaluated by two researchers based on inclusion and exclusion criteria, and basic information of the literature was collected, with wound infection, postoperative complications and wound healing time as the main indicators for analysis. Stata 17.0 software was applied for analysis. Overall, 23 papers and 2099 patients were included, including 1026 patients in the MIPO group and 1073 patients in the IMN group. The results revealed, when compared with IMN treatment, patients with distal tibia fractures who underwent MIPO treatment had a lower incidence of postoperative complications (OR = 0.33, 95% CI: 0.25-0.42, p < 0.001) and a shorter wound healing time (SMD = -1.00, 95% CI: -1.51 to -0.49, p < 0.001), but the incidence of postoperative wound infection was higher (OR = 2.01, 95% CI: 1.35-3.01, p = 0.001). Both MIPO and IMN are excellent treatments for distal tibia fractures. MIPO is effective in reducing the incidence of complications as well as shortening the time of wound healing time but increases the risk of wound infection. In clinical practice, surgeons can make individual choices based on the patient's wishes and proficiency in both techniques.


Assuntos
Fraturas do Tornozelo , Fixação Intramedular de Fraturas , Fraturas da Tíbia , Humanos , Fixação Intramedular de Fraturas/métodos , Consolidação da Fratura , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Fixação Interna de Fraturas/efeitos adversos , Fraturas da Tíbia/cirurgia , Infecção da Ferida Cirúrgica/etiologia , Resultado do Tratamento
13.
Diagnostics (Basel) ; 14(5)2024 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-38472969

RESUMO

Accurate tooth segmentation and numbering are the cornerstones of efficient automatic dental diagnosis and treatment. In this paper, a multitask learning architecture has been proposed for accurate tooth segmentation and numbering in panoramic X-ray images. A graph convolution network was applied for the automatic annotation of the target region, a modified convolutional neural network-based detection subnetwork (DSN) was used for tooth recognition and boundary regression, and an effective region segmentation subnetwork (RSSN) was used for region segmentation. The features extracted using RSSN and DSN were fused to optimize the quality of boundary regression, which provided impressive results for multiple evaluation metrics. Specifically, the proposed framework achieved a top F1 score of 0.9849, a top Dice metric score of 0.9629, and an mAP (IOU = 0.5) score of 0.9810. This framework holds great promise for enhancing the clinical efficiency of dentists in tooth segmentation and numbering tasks.

14.
Sci Total Environ ; 923: 171180, 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38402990

RESUMO

Metal(loid) discharge has led to severe coastal contamination; however, there remains a significant knowledge gap regarding its impact on sediment profiles and depth-resolved bacterial communities. In this study, geochemical measurements (pH, nutrient elements, total and bioavailable metal(loid) content) consistently revealed decreasing nitrogen, phosphorus, and metal(loid) levels with sediment depth, accompanied by reduced alpha diversity. Principal coordinate analysis indicated distinct community compositions with varying sediment depths, suggesting a geochemical influence on diversity. Ecological niche width expanded with depth, favoring specialists over generalists, but both groups decreased in abundance. Taxonomic shifts emerged, particularly in phyla and families, correlated with sediment depth. Microbe-microbe interactions displayed intricate dynamics, with keystone taxa varying by sediment layer. Zinc and arsenic emerged as key factors impacting community diversity and composition using random forest, network analysis, and Mantel tests. Functional predictions revealed shifts in potential phenotypes related to mobile elements, biofilm formation, pathogenicity, N/P/S cycles, and metal(loid) resistance along sediment profiles. Neutral and null models demonstrated a transition from deterministic to stochastic processes with sediment layers. This study provides insights into the interplay between sediment geochemistry and bacterial communities across sediment depths, illuminating the factors shaping these ecosystems.


Assuntos
Arsênio , Ecossistema , Humanos , Baías , Metais/análise , Bactérias , Arsênio/análise , Sedimentos Geológicos/química
15.
J Hazard Mater ; 467: 133703, 2024 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-38354437

RESUMO

As an environmental pollution metal, copper (Cu) exposure-induced toxicity is closely related to mitochondrial damage. Mitochondrial-derived vesicles (MDVs) plays an essential role in mitochondrial quality control and cellular metabolism. However, the mechanism by which MDVs are involved in cellular metabolism under Cu exposure remains unclear. Here, the MDV-carrying protein MIGA2 was identified as a crucial molecule involved in the Cu-induced autophagosomes-lysosomes fusion. Furthermore, Cu exposure significantly promoted MDVs secretion, accompanied by a markedly increased MIGA2 expression in MDVs, as well as accelerated the autophagosomes-lysosomes fusion. However, small RNA interference of SNX9 (the MDVs secretion inductor) and MIGA2 blocked autophagic flux induced by Cu, leading to failure of autophagosomes degradation. Co-immunoprecipitation assay further demonstrated that ATG14 was a regulation target protein of MIGA2. Overexpression and knockdown of ATG14 significantly affected the autophagosomes-lysosomes fusion induced by Cu. Meanwhile, knockdown of ATG14 dramatically reversed the effect of MIGA2-overexpression in promoting autophagosomes-lysosomes fusion, while overexpression of ATG14 shows the opposite effect. These results demonstrated that MDVs-carrying MIGA2 protein promoted autophagosomes-lysosomes fusion induced by Cu. This study demonstrated that MDVs is involved in regulating organelles-to-organelles communication, providing a new insight into the toxicity mechanism of Cu exposure on hepatocytes.


Assuntos
Cobre , Proteínas Mitocondriais , Cobre/toxicidade , Autofagossomos , Mitocôndrias , Fatores de Transcrição , Lisossomos
16.
Water Res ; 252: 121210, 2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38324984

RESUMO

Photo-reduction of arsenic (As) by hydrated electron (eaq-) and recovery of elemental arsenic (As(0)) is a promising pathway to treat As-bearing wastewater. However, previously reported sulfite/UV system needs large amounts of sulfite as the source of eaq-. This work suggests a sulfite/iodide/UV approach that is more efficient and consumes much less chemical reagents to remove As(III) and As(V) and recover valuable As(0) from wastewater, hence preventing the production of large amounts of As-containing hazardous wastes. Our results showed that more than 99.9% of As in the aqueous phase was reduced to highly pure solid As(0) (>99.5 wt%) by sulfite/iodide/UV process under alkaline conditions. Sulfite and iodide worked synergistically to enhance reductive removal of As. Compared with sulfite/UV, the addition of iodide had a substantially greater effect on As(III) (over 200 times) and As(V) (approximately 30 times) removals because of its higher absorptivity and quantum yield of eaq-. Furthermore, more than 90% of the sulfite consumption was decreased by adding a small amount of iodide while maintaining similar reduction efficiency. Hydrated electron (eaq-) was mainly responsible for As(III) and As(V) reductions and removals under alkaline conditions, while both SO3•- and reactive iodine species (e.g., I•, I2, I2•-, and I3-) may oxidize As(0) to As(III) or As(V). Acidic circumstances caused sulfite protonation and the scavenging of eaq- by competing processes. Dissolved oxygen (O2) and CO32- prevented As reduction by light blocking or eaq- scavenging actions, but Cl-, Ca2+, and Mg2+ showed negligible impacts. This study presented an efficient method for removing and recovering As from wastewater.


Assuntos
Arsênio , Poluentes Químicos da Água , Raios Ultravioleta , Iodetos , Águas Residuárias , Poluentes Químicos da Água/análise , Sulfitos , Oxirredução
17.
J Biophotonics ; 17(3): e202300332, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38041248

RESUMO

The erbium-doped yttrium aluminum garnet (Er: YAG) laser has been successfully applied in caries removal; however, little is known about proper parameters of Er: YAG laser on different conditions of caries removal, especially the influence of Er: YAG irradiation on human dental pulp cells (hDPCs). Here, we tested the effects of Er: YAG laser at different output energy levels (100, 200, 300, 400, and 500 mJ) on biobehaviors of hDPCs. To simulate clinical deep caries conditions, hDPCs were cultured on the pulpal side of 500-µm-thick dentin disks in an in vitro pulp chamber model. Temperature change, structural change, and ablation depth of dentin disk were also recorded. The findings suggested that the biological behaviors of hDPCs are strongly correlated with the energy output of the Er: YAG laser. Er: YAG laser irradiation at 100 mJ may be proper and safe for deep caries removal since it would not cause any adverse effect on hDPCs biobehaviors.


Assuntos
Cárie Dentária , Lasers de Estado Sólido , Humanos , Dentina , Suscetibilidade à Cárie Dentária , Polpa Dentária , Cavidade Pulpar , Cárie Dentária/radioterapia
18.
Environ Res ; 245: 118030, 2024 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-38151148

RESUMO

Understanding how abundant (AT) and rare (RT) taxa adapt to diverse environmental stresses is vital for assessing ecological processes, yet remains understudied. We collected sediment samples from Liaoning Province, China, representing rivers (upstream of wastewater outlet), estuaries (wastewater outlets), and Jinzhou Bay (downstream of wastewater outlets), to comprehensively evaluate AT and RT adaptation strategies to both natural stressors (salinity stress) and anthropogenic stressors (metal stress). Generally, RT displayed higher α- and ß-diversities and taxonomic groups compared to AT. Metal and salinity stresses induced distinct α-diversity responses in AT and RT, while ß-diversity remained consistent. Both subcommunities were dominated by Woeseia genus. Metal stress emerged as the primary driver of diversity and compositional discrepancies in AT and RT. Notably, AT responded more sensitively to salinity stress than RT. Stress increased topological parameters in the biotic network of AT subcommunities while decreasing values in RT subcommunities, concurrently loosening interactions of AT with other taxa and strengthening interactions of RT with others in biotic networks. RT generally exhibited greater diversity of metal resistance genes compared to AT. Greater numbers of genes related to salinity tolerance was observed for the RT than for AT. Compared to AT, RT demonstrated higher diversity of metal resistance genes and a greater abundance of genes associated with salinity tolerance. Additionally, deterministic processes governed AT community assembly, reinforced by salinity stress. However, the opposite trend was observed in the RT, where the importance of stochastic process gradually increased with metal stresses. The study is centered on exploring the adaptation strategies of both AT and RT to environmental stress. It underscores the importance of future research incorporating diverse ecosystems and a range of environmental stressors to draw broader and more reliable conclusions. This comprehensive approach is essential for gaining a thorough understanding of the adaptive mechanisms employed by these microorganisms.


Assuntos
Baías , Ecossistema , Águas Residuárias , Bactérias , Estresse Salino , Salinidade
19.
Sci Total Environ ; 913: 169642, 2024 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-38159754

RESUMO

Terbuthylazine (TBA) is a widely prevalent pesticide pollutant, which is a global concern due to its environmental residual. However, the toxic mechanism of TBA have not been fully solved. Here, we explored that TBA exposure disrupts the intestinal flora and aggravated disturbance of mitochondrial quality control and PANapoptosis in hepatocytes via gut-liver axis. Our findings demonstrated that TBA exposure induced significant damage to the jejunum barrier, evidenced by a marked decrease in the expression of Occludin and ZO-1. Moreover. TBA led to intestinal microflora disorder, manifested as the decreased abundance of Firmicutes, and increased abundance of the Nitrospirota, Chloroflexi, Desulfobacterota, Crenarchaeota, Myxococcota, and Planctomycetota. Meanwhile, intestinal microflora disorder affected the biological processes of lipid metabolism and cell growth and death of hepatocytes by RNA-Seq analysis. Furthermore, TBA could induced mitochondrial quality control imbalance, including mitochondrial redox disorders, lower activity of mitochondrial fusion and biogenesis decrease, and increasing level of mitophagy. Subsequently, TBA significantly increased expression levels of pyroptosis, apoptosis and necroptosis-related proteins. In general, these results demonstrated the underlying mechanisms of TBA-induced hepatotoxicity induced via the gut-liver axis, which provides a theoretical basis for further research of ecotoxicology of TBA.


Assuntos
Microbioma Gastrointestinal , Triazinas , Animais , Galinhas , Fígado/metabolismo , Hepatócitos
20.
BMJ Open ; 13(12): e074309, 2023 12 28.
Artigo em Inglês | MEDLINE | ID: mdl-38154879

RESUMO

BACKGROUND: Recently, with the rapid development of the perinatal medical system and related life-saving techniques, both the short-term and long-term prognoses of extremely preterm infants (EPIs) have improved significantly. In rapidly industrialising countries like China, the survival rates of EPIs have notably increased due to the swift socioeconomic development. However, there is still a reasonably lower positive response towards the treatment of EPIs than we expected, and the current situation of withdrawing care is an urgent task for perinatal medical practitioners. OBJECTIVE: To develop and validate a model that is practicable for EPIs as soon as possible after birth by regression analysis, to assess the risk of mortality and chance of survival. METHODS: This multicentre prospective cohort study used datasets from the Sino-Northern Neonatal Network, including 46 neonatal intensive care units (NICUs). Risk factors including maternal and neonatal variables were collected within 1 hour post-childbirth. The training set consisted of data from 41 NICUs located within the Shandong Province of China, while the validation set included data from 5 NICUs outside Shandong Province. A total of 1363 neonates were included in the study. RESULTS: Gestational age, birth weight, pH and lactic acid in blood gas analysis within the first hour of birth, moderate-to-severe hypothermia on admission and adequate antenatal corticosteroids were influencing factors for EPIs' mortality with important predictive ability. The area under the curve values for internal validation of our prediction model and Clinical Risk Index for Babies-II scores were 0.81 and 0.76, and for external validation, 0.80 and 0.51, respectively. Moreover, the Hosmer-Lemeshow test showed that our model has a constant degree of calibration. CONCLUSIONS: There was good predictive accuracy for mortality of EPIs based on influencing factors prenatally and within 1 hour after delivery. Predicting the risk of mortality of EPIs as soon as possible after birth can effectively guide parents to be proactive in treating more EPIs with life-saving value. TRIAL REGISTRATION NUMBER: ChiCTR1900025234.


Assuntos
Lactente Extremamente Prematuro , Unidades de Terapia Intensiva Neonatal , Lactente , Recém-Nascido , Humanos , Feminino , Gravidez , Estudos Prospectivos , Idade Gestacional , Prognóstico
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