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1.
BMC Endocr Disord ; 19(1): 94, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31477080

RESUMO

BACKGROUND: Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS: Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n = 67) and non-functioning (NF) pituitary adenoma (n = 67) were recruited from the outpatient and inpatient patient department of The First Affiliated Hospital, Jinan University from August 2015 to August 2017. Thyroid ultrasonography was performed using an ultrasound system. The cytopathological results of fine-needle aspiration biopsy were analyzed by a pathologist according to the Bethesda system. Twenty-one patients with GH-secreting adenoma and thyroid disease underwent transsphenoidal pituitary adenoma resection and were followed up for 1 year. RESULTS: The prevalence of thyroid disease increased in the GH-secreting adenoma group compared with that in the NF pituitary adenoma group. The number of hypoechoic, isoechogenic, heterogeneous, and vascular thyroid nodules increased in patients with GH-secreting adenoma plus thyroid disease compared with that in patients with NF pituitary adenoma plus thyroid disease. Finally, we found significant decreases in the morphology of solid nodules and significant increases in the morphology of cystic nodules after surgery compared with those before surgery in the cured group. Moreover, the numbers of heterogeneous and vascular thyroid nodules decreased significantly after surgery compared with those before surgery in the cured group. However, the characteristics of the thyroid nodules did not change after surgery compared with those before surgery in the non-cured group. CONCLUSIONS: The numbers of hypoechoic, isoechoic, heterogeneous, and vascular thyroid nodules increased in patients with GH-secreting adenomas. In these patients, surgery resulted in significant changes from solid to cystic nodules and also reduced the numbers of heterogeneous and vascular thyroid nodules.

2.
Placenta ; 83: 63-71, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31477210

RESUMO

INTRODUCTION: The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS: A total of 108 singleton pregnant women were divided into three groups: control, late-onset ICP, and early-onset ICP. Enzyme-linked immunosorbent assays were used to detected maternal serum CRH, UCN, and WFS1 levels. Western blotting and real-time polymerase chain reaction were conducted to quantify placental protein and mRNA levels of CRH, UCN, and WFS1. Pearson correlation scatterplots and Pearson correlation matrix were employed to testify the correlation. RESULTS: Placental WFS1 had a positive relation with placental UCN (r = 0.69, P < 0.05) and serum UCN (r = 0.36, P < 0.05). Placental CRH was positively correlated with maternal serum CRH (r = 0.53, P < 0.05). Maternal serum and placental levels of CRH, UCN, and WFS1 significantly increased in the early-onset ICP group compared with the control group (P < 0.05). Placental levels of UCN and WFS1 in the early-onset ICP group were significantly elevated and higher in comparison with the late-onset ICP group (P < 0.05). However, the transcriptional levels of CRH, UCN, and WFS1 were impaired in the early-onset ICP group. DISCUSSION: Our study revealed that transcription and translation of WFS1, CRH, and UCN were altered during pregnancies complicated by early-onset ICP. This disrupted compensatory response mediated by WFS1 and CRH family peptides in early-onset ICP may play a significant role in the pathogenesis of sudden fetal death in acute fetal hypoxia.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31478596

RESUMO

OBJECTIVE: Dexmedetomidine (DEX) exhibits neuroprotective effects as a multifunctional neuroprotective agent in numerous neurological disorders. However, in traumatic brain injury (TBI), the molecular mechanisms of these neuroprotective effects remain unclear. The present study investigated whether DEX, which has been reported to exert protective effects against TBI, could attenuate neuroinflammatory-induced apoptosis and clarified the underlying mechanisms. METHODS: A weight-drop model was established, and DEX was intraperitoneally injected 30 min after inducing TBI in rats. The water content in the brain tissue was measured. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assays were performed on histopathological tissue sections to evaluate neuronal apoptosis. Enzyme-linked immunosorbent assay and PCR were applied to detect the levels of the inflammatory factors, TNF-α, IL-1ß, IL-6, and NF-κB. RESULTS: TBI-challenged rats exhibited significant neuronal apoptosis, which was characterized via the wet-to-dry weight ratio, neurobehavioral functions, TUNEL assay results and the levels of cleaved caspase-3, Bax upregulation and Bcl-2, which were attenuated by DEX. Western blot, immunohistochemistry, and PCR results revealed that DEX promoted Nrf2 expression and upregulated expression of the Nrf2 downstream factors, HO-1 and NQO-1. Furthermore, DEX treatment markedly prevented the downregulation of inflammatory response factors, TNF-α, IL-1ß and NF-κB, and IL-6. INTERPRETATION: Administering DEX attenuated inflammation-induced brain injury in a TBI model, potentially via the Nrf2 signaling pathway.

4.
Medicine (Baltimore) ; 98(36): e17068, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31490405

RESUMO

INTRODUCTION: Current treatment of pediatric distal metaphyseal tibial/fibular fractures is challenging due to poor skin and soft tissue coverage and limited blood supply to the distal tibia area in children. It remains unknown whether the SK combined external fixator (made by Double Medical Technology Inc., China) is effective for the treatment of distal metaphyseal tibia/fibula fractures in children. HYPOTHESIS: We hypothesized that SK combined external fixator could achieve satisfying outcomes for pediatric distal metaphyseal tibia/fibula fractures. PATIENTS AND METHODS: A total of 19 pediatric patients with a median age of 6 years (range: 3.8-12.0 years), who had distal tibia/fibula metaphyseal fractures and attended our hospital between January 2017 and November 2017, were evaluated. All patients with tibia fracture had closed reduction and percutaneously fixed SK combined external fixators. Radiographs were taken at an average of every 4 weeks to evaluate the healing of the fracture. Complications were recorded, and the stability of the pin clamp and rod were also checked. Follow-up was conducted for up to 13 months. All patients provided informed consent for publication of the case. RESULTS: All patients achieved a satisfactory clinical outcome at the final follow-up. Weight-bearing exercises were started at post-operative 2 weeks. Bone union was obtained at 8 weeks post-operation on average. No delayed healing or nonunion was observed, although one case of pin site infection and three cases of pin clamp loosening occurred. DISCUSSION: Three-dimensional SK combined external fixators are light, easy to apply, minimally invasive, and result in low rates of complications. They provide excellent stability for pediatric distal tibia/fibula metaphyseal fractures. LEVEL OF EVIDENCE: IV.

5.
Microbiologyopen ; : e924, 2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31482697

RESUMO

An approach to culturing attached and suspended forms of Rhodopseudomonas faecalis by using compound fish feed with tap water in transparent containers is reported in this study. The ratio of fish feed to tap water was 14.3-50.8 g/L, and no other inoculum or substances were added during the culture process. When the ratio of fish feed to tap water was 14.3 g/L, the highest total nitrogen, total phosphorus, and total dissolved carbon content recorded in the water in the containers were approximately 730 mg/L, 356 mg/L, and 1,620 mg/L, respectively, during the process of feed decay. Comamonas, Rhodopseudomonas, and Clostridium successively dominated during the culture process. Rhodopseudomonas was the most common dominant genus in both the attached and suspended forms when the water was dark red, and the relative operational taxonomic unit abundance reached 80-89% and 24.8%, respectively. The dominant species was R. faecalis. The maximum thickness of attached bacteria and the biomass of attached Rhodopseudomonas reached up to 0.56 mm and 7.5 mg/cm2 , respectively. This study provides a method for the mass culture of Rhodopseudomonas by using the fermentation of aquatic compound fish feed.

6.
J Acoust Soc Am ; 146(1): 72, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31370583

RESUMO

The acoustic black hole (ABH) effect is realized in thin plate structures with a decreasing thickness according to a power-law function, and offers potential applications for structure vibration damping enhancement and free-field noise radiation suppression. In this paper, a wavenumber domain method (WNDM) is proposed for the analysis of vibro-acoustic coupling and internal noise reduction mechanism of a pentahedral cavity enclosed by a flexible plate with a two-dimensional ABH indentation, subject to a point force excitation. The system response of the ABH plate-cavity is computed by a validated finite element model. The relationship between the space-averaged sound energy inside the cavity and the spectra of the structural displacement and the acoustic mode of the cavity is established. This allows revealing a dual physical mechanism behind the observed noise reduction: amplitude reduction and mismatching between the wavenumber spectra of the plate displacement and the acoustic field, which results in a weakened vibro-acoustic coupling. An additional configuration with an ABH embedded in an irregular pentagonal wall of the cavity is examined. Despite the increasing complexity in the geometry of the coupling interface and its coupling with the cavity, numerical analyses confirm the generality of the observed physical phenomena and the applicability of the proposed WNDM to more complex system configurations.

7.
Clin Exp Med ; 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31463831

RESUMO

Thrombocytopenia is the second most common hematological disease during pregnancy and is mainly caused by gestational thrombocytopenia, immune thrombocytopenia, or preeclampsia/HELLP syndrome. This study aims to investigate the causes and pregnancy outcomes of thrombocytopenia in pregnancies with platelet counts below 50 × 109/L. We retrospectively analyzed the pregnancies diagnosed with severe thrombocytopenia at a tertiary care center in western China between January 2009 and December 2017. All enrolled pregnancies were divided into three groups according to the lowest platelet counts: group A (30-50 × 109/L), group B (10-30 × 109/L), and group C (< 10 × 109/L). Maternal and fetal outcomes were observed and compared among these three platelet levels. A total of 533 consecutive pregnancies were included. A relatively large proportion (37.3%, 199/533) of them showed a history of thrombocytopenia before pregnancy or during a previous pregnancy. Most of the women (70.2%, 374/533) received corticosteroids, intravenous immunoglobulin, or platelet transfusion treatments. The incidence of preterm birth < 37 weeks (26.3%, 15/57), cesarean section (93%, 53/57), and neonatal intensive care unit (NICU) admission (31.6%, 18/57) occurred significantly more often in group C than in groups A and B. Neonatal platelet counts were detected in 28.2% of the infants (155/549), and neonatal thrombocytopenia was found in 40.6% of the infants (63/155). Intracranial hemorrhage occurred in 0.9% of the neonates (5/549) throughout the study period, with neonatal nadir platelet counts between 20 × 109/L and 245 × 109/L. One perinatal death occurred in group C. Pregnancies with the lowest platelet counts below 10 × 109/L are more often complicated by preterm birth, cesarean section, and NICU admission compared with those lowest platelet counts 30-50 × 109/L and 10-30 × 109/L. Neonatal intracranial hemorrhage was uncommon in pregnancies with severe thrombocytopenia. Active management should be performed to avoid possible preterm birth and neonatal NICU admission in pregnancies with the lowest platelet counts below 10 × 109/L.

8.
Eur Radiol ; 2019 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-31444599

RESUMO

OBJECTIVE: The aim of this study was to investigate whether intraplacental texture features from routine placental MRI can objectively and accurately predict invasive placentation. MATERIAL AND METHODS: This retrospective study includes 99 pregnant women with pathologically confirmed placental invasion and 56 pregnant women with simple placenta previa. All participants underwent magnetic resonance imaging after 24 gestational weeks. The placenta was segmented in sagittal images from both turbo spin echo (TSE) and balanced turbo field echo (bTFE) sequences. Textural features were extracted from the both original and Laplacian of Gaussian (LoG)-filtered MRI images. An automated machine learning algorithm was applied to the extracted feature sets to obtain the optimal preprocessing steps, classification algorithm, and corresponding hyper-parameters. RESULTS: A gradient boosting classifier using all textual features from original and LoG-filtered TSE images and bTFE images identified by the automated machine learning algorithm achieved the optimal performance with sensitivity, specificity, accuracy, and area under ROC curve (AUC) of 100%, 88.5%, 95.2%, and 0.98 in the prediction of placental invasion. In addition, textural features that contributed to the prediction of placental invasion differ from the features significantly affected by normal placenta maturation. CONCLUSIONS: Quantifying intraplacental heterogeneity using LoG filtration and texture analysis highlights the different heterogeneous appearance caused by abnormal placentation relative to normal maturation. The predictive model derived from automated machine learning yielded good performance, indicating the proposed radiomic analysis pipeline can accurately predict placental invasion and facilitate clinical decision-making for pregnant women with suspicious placental invasion. KEY POINTS: • The intraplacental texture features have high efficiency in prediction of invasive placentation after 24 gestational weeks. • The features with dominated predictive power did not overlap with the features significantly affected by gestational age.

9.
J Colloid Interface Sci ; 555: 124-131, 2019 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-31377638

RESUMO

Environmental stability is of great interest for sol-gel porous antireflective (AR) coatings. In this work, sol-gel silica AR coatings with excellent environmental stability were prepared via ammonia vapor treatment (AVT) combined with organosilane (hexamethyldisilazane (HMDS) or hexadecyltrimethoxysilane (HTMS)) vapor treatment. The surface free energy (SFE) of the coatings treated with different approaches was estimated through Owens-Wendt method combined with Wenzel equation from the contact angles of water, glycerol and diiodomethane. Scanning electron microscope and Fourier transform infrared spectroscopy were employed to study the surface morphology and chemical composition of the silica coatings treated with different methods. The silica coatings treated by combined vapor phase method possess the SFE of 24.11 mJ·m-2 for N-HD-SiO2 and 34.18 mJ·m-2 for N-HT-SiO2. After being placed in a 90%RH humid environment for 2 months, the peak transmittance of BK7 glasses coated with N-HD-SiO2 and N-HT-SiO2 only decreases by 0.58% and 0.95%, respectively. Meanwhile, N-HD-SiO2 and N-HT-SiO2 coated BK7 glasses also show quite stable optical transmittance after exposure to a vacuum oil environment for 2 months. The mechanism of the combined vapor phase surface treatment is discussed based on the combination analysis of surface morphology, chemical composition and SFE of the coatings.

10.
Mol Med Rep ; 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31432173

RESUMO

Accumulating evidence has indicated that noncoding RNAs are involved in intervertebral disc degeneration (IDD); however, the competing endogenous RNA (ceRNA)­mediated regulatory mechanisms in IDD remain rarely reported. The present study aimed to comprehensively investigate the alterations in expression levels of circular RNA (circRNA), long noncoding RNA (lncRNA), microRNA (miRNA/miR) and mRNA in the nucleus pulposus (NP) of patients with IDD. In addition, crucial lncRNA/circRNA­miRNA­mRNA ceRNA interaction axes were screened using the GSE67567 microarray dataset obtained from the Gene Expression Omnibus database. After data preprocessing, differentially expressed circRNAs (DECs), lncRNAs (DELs), miRNAs (DEMs) or genes (DEGs) between IDD and normal controls were identified using the Linear Models for Microarray data method. A protein­protein interaction (PPI) network was constructed for DEGs based on protein databases, followed by module analysis. The ceRNA network was constructed based on the interaction between miRNAs and mRNAs, and lncRNAs/circRNAs and miRNAs. The underlying functions of mRNAs were predicted using the Database for Annotation, Visualization and Integrated Discovery database. The present study identified 636 DECs, 115 DELs, 84 DEMs and 1,040 DEGs between patients with IDD and control individuals. PPI network analysis demonstrated that Fos proto­oncogene, AP­1 transcription factor subunit (FOS), mitogen­activated protein kinase 1 (MAPK1), hypoxia inducible factor 1 subunit α (HIF1A) and transforming growth factor ß1 (TGFB1) were hub genes and enriched in modules. Metastasis­associated lung adenocarcinoma transcript 1 (MALAT1)/hsa_circRNA_102348­hsa­â€‹miR­185­5p­TGFB1/FOS, MALAT1­hsa­miR­155­5p­HIF1A, hsa_circRNA_102399­hsa­miR­302a­3p­HIF1A, MALAT1­hsa­â€‹miR­519d­3p­MAPK1 and hsa_circRNA_100086­hsa­miR­509­3p­MAPK1 ceRNA axes were obtained by constructing the ceRNA networks. In conclusion, these identified ceRNA interaction axes may be crucial targets for the treatment of IDD.

11.
Bioresour Technol ; 291: 121919, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31376667

RESUMO

Biofilm processes are widely used in wastewater treatment. The biofilm has highly heterogeneous interior structure, which can significantly affect the transport processes and the biological reactions over the biofilm. This study for the first time detailed the complicated velocity and concentration fields of substrate in a real biofilm structure. With a real biofilm interior being profiled and meshed to numerical solutions, the flow-through mode has significant distortion of inflow velocity fields and concentration distributions, which lead to enhanced biological reactions at regimes nearby major pores. Conversely, the crossflow mode depends weakly on the biofilm interior structure. The uniform biofilm model fails to describe the real biofilm processes. Future research needs based on real biofilm structures were discussed.

12.
ACS Appl Mater Interfaces ; 11(34): 31520-31531, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31369238

RESUMO

Studies on carbon fiber (CF)/poly(ether ether ketone) (PEEK) fiber hybrid textiles were initiated several decades ago because their flexibility and conformability make them a promising alternative to traditional prepregs. The adhesion between the CFs and PEEK is mostly controlled by their inherent surface properties and mutual wettability. However, details of these properties remain largely unknown, especially those of PEEK. Therefore, to determine the surface and interfacial properties of these fibers, we performed a comprehensive study and characterized their surface topography (atomic force microscopy, scanning electron microscopy), surface chemistry [X-ray photoelectron spectrometry (XPS), acid-base titration], surface energies (wetting tests, acid-base approach), and interfacial mechanical properties [droplet test, interfacial shear strength (IFSS)]. These experiments were complemented by a theoretical approach to the prediction of the surface energy components (parachor) and contact angles of PEEK. We found good agreement between the results obtained by XPS and wetting tests (base-to-acid surface energy component ratio), as well as between the predicted and measured surface energy and contact angles. The results highlight the consistency and reliability of the proposed methodology. We found that both CFs and PEEK fibers appear to be smooth at the nanoscale and have large dispersive and basic surface energy components. The IFSS of CF/PEEK is significantly higher (44.87 ± 5.76 MPa) compared to that of other thermoplastic systems. The findings not only demonstrate the potential of CF/PEEK hybrid textiles but also emphasize the need to further increase the compatibility between CFs and PEEK fibers by increasing the acidic component of CF surfaces. Surface treatments and the design of a suitable sizing are potential methods to achieve this objective in future studies.

13.
ISA Trans ; 2019 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-31395284

RESUMO

In order to overcome the influence of non-adaptive selection of non-stationary coefficient threshold of compound interpolation envelope (CIE) method on decomposition performance of local mean decomposition (LMD), a LMD method based on improved compound interpolation envelope (ICIE) is proposed in this paper. Firstly, combining the CIE with fractal box dimension, an improved envelope processing method, named ICIE, is proposed. Secondly, an improved LMD-based ICIE is presented and abbreviated as ICIELMD. Finally, three different data-sets, including simulation signal, rolling bearing data-sets from Case Western Reserve University (CWRU) and National Aeronautics and Space Administration (NASA), are used to complete the comparative experiments between the proposed ICIELMD and state-of-the-art methods (CIELMD) and demonstrate the effectiveness of the ICIELMD method. The experimental results show that the proposed method achieves comparable or slightly better than the other methods, and provides a new solution for complex signal analysis of rolling bearing faults.

14.
Mol Cell ; 2019 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-31420216

RESUMO

The mitochondrial pathway of apoptosis is controlled by the ratio of anti- and pro-apoptotic members of the Bcl-2 family of proteins. The molecular events underlying how a given physiological stimulus changes this ratio to trigger apoptosis remains unclear. We report here that human 17-ß-estradiol (E2) and its related steroid hormones induce apoptosis by binding directly to phosphodiesterase 3A, which in turn recruits and stabilizes an otherwise fast-turnover protein Schlafen 12 (SLFN12). The elevated SLFN12 binds to ribosomes to exclude the recruitment of signal recognition particles (SRPs), thereby blocking the continuous protein translation occurring on the endoplasmic reticulum of E2-treated cells. These proteins include Bcl-2 and Mcl-1, whose ensuing decrease triggers apoptosis. The SLFN12 protein and an apoptosis activation marker were co-localized in syncytiotrophoblast of human placentas, where levels of estrogen-related hormones are high, and dynamic cell turnover by apoptosis is critical for successful implantation and placenta development.

15.
Artigo em Inglês | MEDLINE | ID: mdl-31418538

RESUMO

Population pharmacokinetics of rolapitant and its active metabolite M19 were studied in 482 patients receiving this neurokinin-1 receptor antagonist in combination with a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone for prevention of chemotherapy-induced nausea and vomiting (CINV). Patients received a single dose of rolapitant (range, 9-180 mg) before administration of moderately or highly emetogenic chemotherapy. Population pharmacokinetic analysis was performed via nonlinear mixed-effects modeling. Rolapitant pharmacokinetics was best characterized by a 2-compartment model. Population typical values were estimated to be 0.962 L/h for apparent oral clearance and 214 L for central compartment volume of distribution. The intercompartment clearance and peripheral compartment volume of distribution was estimated to be 2.79 L/h and 164 L, respectively. Metabolite M19 pharmacokinetics was described by a 1-compartment model with an apparent metabolite clearance of 1.83 L/h. Intersubject variability was moderate for pharmacokinetics parameters. Weight positively correlated with central compartment volume of distribution and peripheral compartment volume of distribution but not with apparent oral clearance. No other demographic, clinical, or pathophysiologic covariates, including liver and renal function, influenced rolapitant pharmacokinetics. A slight positive trend was observed between rolapitant exposure and efficacy (ie, complete response defined as no emesis and no use of rescue medication) in the delayed phase of CINV (>24-120 hours after chemotherapy). This further supports the 180-mg dose of rolapitant in CINV patients. In summary, this validated population pharmacokinetic model satisfactorily describes pharmacokinetics of rolapitant and M19 in patients with CINV. These results support the recommendation that no dose adjustment for patient variables investigated is necessary.

16.
J Phys Chem B ; 123(32): 7055-7060, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31365259

RESUMO

The temperature dependences of the peak positions in pair distribution functions G(r) of pure metallic zinc (Zn) and indium (In) liquids have been studied using high-energy X-ray diffraction together with ab initio molecular dynamic simulations. It has been demonstrated that the first peak positions in G(r) of both Zn and In move to small r, whereas the second peak positions exhibit opposite movements with increasing temperature, originating from different thermal responses of polyhedron connections. However, the third, above peaks in G(r) in both liquids shift to large r with the expansion coefficients smaller than the values of bulk liquids.

17.
Medicine (Baltimore) ; 98(34): e16917, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31441873

RESUMO

RATIONALE: Delayed cerebrospinal fluid (CSF) leak is a rare and terrible complication after cervical surgery, potentially causing morbidity or even threatening life. PATIENT CONCERNS: A 55-year-old Chinese male, with a history of hypertension for 8 years, complained of numbness and weakness of both upper limbs for 10 years. Strength of right upper limb triceps and wrist extensor muscle was slight weakness. Bilateral Hoffman sign was positive. Cervical magnetic resonance imaging (MRI) indicated multilevel cervical spondylotic myelopathy. We performed cervical laminoplasty for that patient on August 23, 2018. Nevertheless, he abruptly complained of dizziness and vision, but the wound condition was good. Cervical MRI showed delayed cerebrospinal fluid leak on October 15, 2018. DIAGNOSES: He was diagnosed with delayed CSF leak after cervical laminoplasty. INTERVENTIONS: We performed lateral ventriculo-peritoneal shunt (LVPS) for that patient on October 17, 2018. OUTCOMES: At 3-month follow-up, the treatment has a good outcome and there is no recurrence of clinical symptoms. LESSONS: Delayed CSF leak after cervical laminoplasty is rare. Once diagnosed, surgery is needed as soon as possible. LVPS has been proven an effective treatment for this server disease.


Assuntos
Vazamento de Líquido Cefalorraquidiano/cirurgia , Laminectomia/efeitos adversos , Derivação Ventriculoperitoneal/métodos , Vazamento de Líquido Cefalorraquidiano/etiologia , Vértebras Cervicais/diagnóstico por imagem , Vértebras Cervicais/cirurgia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
18.
ACS Nano ; 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31397999

RESUMO

Cancer photodynamic therapy (PDT) represents an attractive local treatment in combination with immunotherapy. Successful cancer PDT relies on image guidance to ensure the treatment accuracy. However, existing nanotechnology for co-delivery of photosensitizers and image contrast agents slows the clearance of PDT agents from the body and causes a disparity between the release profiles of the imaging and PDT agents. We have found that the photosensitizer Chlorin e6 (Ce6) is inherently bound to immunoglobulin G (IgG) in a nanomolarity range of affinity. Ce6 and IgG self-assemble to form the nanocomplexes termed Chloringlobulin (Chlorin e6 + immunoglobulin G). Chloringlobulin enhances the Ce6 concentration in the tumor without changing its elimination half-life in blood. Utilizing the immune checkpoint inhibitor antiprogrammed death ligand 1 (PD-L1) (αPD-L1) to prepare αPD-L1 Chloringlobulin, we have demonstrated a combination of Ce6-based red-light fluorescence image-guided surgery, stereotactic PDT, and PD-L1 blockade therapy of mice bearing orthotopic glioma. In mice bearing an orthotopic colon cancer model, we have prepared another Chloringlobulin that allows intraoperative fluorescence image-guided PDT in combination with PD-L1 and cytotoxic T lymphocyte antigen 4 (CTLA-4) dual checkpoint blockade therapy. The Chloringlobulin technology shows great potential for clinical translation of combinatorial intraoperative fluorescence image-guided PDT and checkpoint blockade therapy.

19.
Artigo em Inglês | MEDLINE | ID: mdl-31363802

RESUMO

Metals from the natural environment have potential hypertension effects. However, relevant studies on this topic are few. A total of 1358 adults aged 18-74 years from Chizhou, Maanshan, and Tongling of Anhui Province participated in the baseline study from 2014 to 2015. The follow-up study was performed from 2016 to 2017. Inductively coupled plasma optical emission spectrometry (7000 DV) was used to measure urinary Cr, Mn, Fe, Cu, and Zn of residents. Urinary concentrations of Cd determined via TAS-900 atomic absorption spectrophotometry at 228.8 nm wavelength. A total of 275 hypertension cases were identified. After adjusting for sociodemographic factors and risk factors for hypertension, four metals (Cd, Cr, Cu, and Mn) were significantly associated with hypertension in the single-metal model. Upon including all metals in the same model, the hazard ratios of the highest quartiles Cd and Cu compared with the reference group were 1.42 (95% confidence interval [CI] 1.09-2.02) and 1.56 (95% CI 1.16-2.09) for cases of hypertension. Our findings suggested that high levels of Cd and Cu might increase the incidence of hypertension. Further studies involving larger population should be conducted to confirm these findings.

20.
Clin Rheumatol ; 2019 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-31377919

RESUMO

BACKGROUND: Hypertension disorders in pregnancy (HDP) were common complications in women with systemic lupus erythematosus (SLE). However, the impact of HDP and the measures to prevent HDP-related fetal adverse pregnancy outcomes (APOs) remained to be explored. METHODS: A multicenter retrospective study of 342 pregnant women with SLE was performed. Variables related to SLE and APOs were recorded. Fetal development was evaluated by umbilical artery Doppler ultrasonography. RESULTS: HDP was diagnosed in 45 (13.2%) patients, including pre-eclampsia in 42 and gestational hypertension in 3. Patients with HDP had higher incidence of preterm birth (71.1% vs 20.9%, P < 0.001), intrauterine growth retardation (IUGR) (37.8% vs 11.8%, P < 0.001), low-birth-weight infants (62.2% vs 17.2%, P < 0.001), and very-low-birth-weight infants (37.8% vs 2.7%, P < 0.001), compared with lupus patients without HDP. A total of 35 (77.8%) HDP patients had disease activation during pregnancy. All the events occurred during the second and third trimesters, mainly presenting as moderate-to-high activity (65.7%). Active disease [odds ratios (OR) = 3.9, 95% confidential interval (CI) 1.5-9.7, P = 0.004] and positive anticardiolipin (aCL) antibody (OR = 7.6, 95% CI 2.7-18.6, P < 0.001) were independent risk factors for HDP in lupus patients. Doppler RI and S/D ratio predicted APOs in patients with HDP. The optimal cut-off values for RI and S/D ratio were 0.7 (sensitivity 48.1%, specificity 53.3%) and 3.4 (sensitivity 66.7%, specificity 100%), respectively. CONCLUSIONS: HDP was a common pregnant complication and caused various fetal and maternal adverse outcomes in patients with SLE. Umbilical artery Doppler ultrasonography was effective in predicting fetal APOs in lupus patients with HDP. Key Points • HDP induced preterm birth, IUGR, low-birth-weight infants, and very-low-birth-weight infants in patients with SLE. • HDP led to lupus activation during the second and third trimesters. • Disease activation and aCL positivity were predictors for HDP. • RI and S/D ratio from umbilical artery Doppler predicted APOs in patients with HDP.

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