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1.
JAMA Netw Open ; 5(9): e2232133, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36129711

RESUMO

Importance: One of the ordinary manifestations of Parkinson disease (PD) is anxiety, which remains untreated. Anxiety is closely associated with the accelerated progression of PD. Efficacy of acupuncture for anxiety has been reported. However, to date, there are no data on acupuncture's effectiveness on anxiety for patients with PD. Objective: To investigate the effect of acupuncture vs sham acupuncture for treating anxiety in patients with PD. Design, Setting, and Participants: This is randomized, double-blinded, clinical trial enrolled patients between June 20, 2021, and February 26, 2022. Final follow-up was April 15, 2022. Patients with Parkinson disease and anxiety were allocated randomly (1:1) to receive acupuncture or sham acupuncture for 8 weeks. Acupuncture operators, outcome measures evaluators, and statistical analysts were blinded to the grouping of patients. Patients were blinded to their own grouping during the study. This study took place in the Parkinson clinic of a hospital in China. Interventions: Real acupuncture or sham acupuncture for 8 weeks. Main Outcomes and Measures: Primary outcome was Hamilton Anxiety Scale (HAM-A) score. Secondary outcomes were scores on the Unified Parkinson Disease Rating Scale (UPDRS), 39-item Parkinson Disease Questionnaire (PDQ-39), and serum levels of the adrenocorticotropic hormone (ACTH) and cortisol (CORT). Results: Seventy eligible patients were enrolled, including 34 women (48.5%) and 36 men (51.4%). Sixty-four patients (91%) completed the intervention and the 8-week follow-up, including 30 women (46.9%) and 34 men (53.1%) with a mean (SD) age of 61.84 (8.47) years. At the end of treatment, the variation of HAM-A score was 0.22 (95% CI, -0.63 to 1.07; P = .62) between the real acupuncture and sham acupuncture groups. At the end of follow-up, the real acupuncture group had a significant 7.03-point greater (95% CI, 6.18 to 7.88; P < .001) reduction in HAM-A score compared with the sham acupuncture group. Four mild adverse reactions occurred during the study. Conclusions and Relevance: This study found acupuncture to be an effective treatment for anxiety in patients with PD. These findings suggest that acupuncture may enhance the wellbeing of patients who have Parkinson disease and anxiety. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2100047253.


Assuntos
Terapia por Acupuntura , Doença de Parkinson , Hormônio Adrenocorticotrópico , Ansiedade/terapia , Feminino , Humanos , Hidrocortisona , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/complicações , Doença de Parkinson/terapia , Salicilamidas
2.
Biomimetics (Basel) ; 7(3)2022 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-36134942

RESUMO

The introduction of nanomaterials into polymethyl methacrylate (PMMA) resin has been effective for mechanically reinforcing PMMA for application in oral denture bases. However, these methods cannot simultaneously improve the mechanical and antibacterial properties, which limits widespread clinical application. Here, we self-assembled binary nanocomposites of boron nitride nanosheets (h-BNNs) and silver nanoparticles (AgNPs) as nanofillers and incorporated the nanofillers into PMMA. The aim of this study was to achieve antibacterial effects while significantly improving the mechanical properties of PMMA and provide a theoretical basis for further clinical application. We employed scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman spectroscopy (Raman), Ultraviolet visible spectrum (UV) and atomic force microscopy (AFM) to investigate the microscopic morphology and composition of PMMA containing nanocomposites with different mass fraction. In addition, the content of the h-BNNs/AgNPs was 1 wt%, and the compressive strength and flexural strength of pure PMMA were improved by 53.5% and 56.7%, respectively. When the concentration of the nanocomposite in the PMMA resin was 1.4 wt%, the antibacterial rate was 92.1%. Overall, synergistically reinforcing PMMA composite resin with a multi-dimensional nanocomposite structure provided a new perspective for expanding not only the application of resins in clinical settings but also the research and development of new composite resins.

3.
Artigo em Inglês | MEDLINE | ID: mdl-36141681

RESUMO

Impacted by the COVID-19 epidemic, the human sub-health in national high-tech zones (hereinafter referred to as high-tech zones) has become more prominent. It is critical for the mental sub-health group in the high-tech zone to relieve the anxiety and tension caused by the pressure of life and work. This paper uses SketchUp virtual engine (Unity 2019) software, and 3D roaming technology to carry out the ecological landscape transformation design of the Baotzixi ecological corridor in the East Lake High-tech Zone, to construct a 3D roaming landscape scene and measure its therapeutic effect by inviting subjects to participate in an interactive experience experiment on the ErgoLAB platform. The results illustrate that: (1) the thermogram trend shows that the more attractive the 3D roaming landscape scene is, the stronger the subjects' interest is; (2) the participants have a positive emotional arousal state in the immersive experience of the 3D roaming landscape scene after the modification design; and (3) the mean skin conductance (SC) fluctuation variance of the subjects is 5.819%, indicating that the healing effect is significant in the state of positive emotional arousal. The research results show that there is a connection between the subjects and the 3D roaming landscape scene after the transformation design of "high interest, emotional arousal and significant healing".

4.
Viruses ; 14(9)2022 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-36146714

RESUMO

Positive-sense single-stranded RNA viruses replicate in virus-induced membranous organelles for maximum efficiency and immune escaping. The replication of potato virus X (PVX) takes place on the endoplasmic reticulum (ER); however, how PVX-encoded RNA-dependent RNA polymerase (RdRp) is associated with the ER is still unknown. A proline-kinked amphipathic α-helix was recently found in the MET domain of RdRp. In this study, we further illustrate that the first α-helix of the MET domain is also required for ER association. Moreover, we found that the MET domain forms multimers on ER and the first α-helix is essential for multimerization. These results suggest that the RdRp of PVX adopts more than one hydrophobic motif for membrane association and for multimerization.

5.
Comput Intell Neurosci ; 2022: 2159578, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36148427

RESUMO

As an important economic sector, logistics is becoming more important, if not crucial, in economic growth. In our nation, the logistics industry is booming, and it's just getting better. However, in addition to focusing on the positive aspects of our country's logistics industry's development, we should also analyze and address the negative aspects of our country's logistics industry's development. The overall logistics pattern has not yet been formed, and there is an urgent need for systematic construction. The regional development is extremely unbalanced. By comparing the logistics performance indices of various Belt and Road countries, this research aims to examine the major elements influencing overall logistics performance. Second, we introduce the Moran index to explore the geographical association of the subdivision indicators of the logistics performance index using the spatial econometric model. The bootstrap DEA analysis method examines and ranks the countries' logistics performance indexes, determines our country's advantages and disadvantages in comparison to other Belt and Road countries, and executes specific improvement strategies that will enhance logistics and boost the overall growth of our country's logistics sector.

6.
Chemosphere ; 308(Pt 3): 136389, 2022 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-36099990

RESUMO

Biochar (e.g. pyrochar and hydrochar) is considered a promising adsorbent for Cd removal from aqueous solution. Considering the vastly different physicochemical properties between pyrochar and hydrochar, the Cd2+ sorption capacity and mechanisms of pyrochars and hydrochars should be comparatively determined to guide the production and application of biochar. In this study, the hydrochars and pyrochars were prepared from Napier grass by hydrothermal carbonization (200 and 240 °C) and pyrolysis (300 and 500 °C), respectively, and the physicochemical properties and Cd2+ sorption performances of biochars were systematically determined. The pyrochars had higher pH and ash content as well as better stability, while the hydrochars showed more oxygen-containing functional groups (OFGs) and greater energy density. The pseudo second order kinetic model best fitted the Cd2+ sorption kinetics data of biochars, and the isotherm data of pyrochar and hydrochar were well described by Langmuir and Freundlich models, respectively. In comparison with hydrochar, the pyrochar exhibited better Cd2+ sorption capacity (up to 71.47 mg/g). With increasing production temperature, the Cd2+ sorption capacity of pyrochar elevated, while the reduction was found for hydrochar. The mineral interaction, complexation with surface OFGs, and coordination with π electron were considered the main mechanisms of Cd2+ removal by biochars. The minerals interaction and the complexation with OFGs was the dominant mechanism of Cd2+ removal by pyrochars and hydrochars, respectively. Therefore, the preparation technique and temperature have significant impacts on the sorption capacity and mechanisms of biochar, and pyrochar has better potential for Cd2+ removal than the congenetic hydrochar.

7.
Front Surg ; 9: 894083, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36090333

RESUMO

Background: Enhanced recovery after surgery (ERAS), a new clinical surgical concept, has been applied in many surgical disciplines with good clinical results for the past 20 years. Bibliometric analysis is an effective method to quantitatively evaluate the academic productivity. This report aimed to perform a scientometric analysis of the ERAS research status and research hotspots. Methods: Comprehensive scientific mapping analysis of a wide range of literature metadata using the scientometric tools, including the Bibliometrix R Package, Biblioshiny, and CiteSpace. Data were retrieved from the Web of Science Core Collection database of original articles from 2001 to 2020. Specific indicators and maps were analyzed to show the co-authorship, co-institute, co-country, co-citation, and international cooperation. Automatic literature screening, unsupervised cluster filtering, and topic cluster identification methods were used to display the conceptual framework and thematic evolution. Results: A total of 1,403 research projects drafted by 6,966 authors and published in 413 sources were found. There was an exponential growth in the number of publications on ERAS. There were 709 collaborations between authors from different countries, and the US, China, and the UK had the greatest number of publications. The WORLD JOURNAL OF SURGERY, located in Bradford's Law 1, had the highest number of published articles (n = 1,276; total citations = 3,193). CiteSpace network analysis revealed 15 highly correlated cluster ERAS studies, and the earliest study was on colonic surgery, and ERAS was recently applied in cardiac surgery. The etiology of ERAS is constantly evolving, with surgery and length of hospital as the main topics. Meta-analyses and perioperative care have tended to decline. Conclusion: This is the first scientometric analysis of ERAS to provide descriptive quantitative indicators. This can provide a better understanding of how the field has evolved over the past 20 years, help identify research trends, and provide insights and research directions for academic researchers, policymakers, and medical practitioners who want to collaborate in these areas in the future.

8.
Artigo em Inglês | MEDLINE | ID: mdl-36106683

RESUMO

The scalable and durable e lectrosynthesis of high-valued organonitrogen compounds from carbon- and nitrogen-containing small molecules , especially operating at a high current density , is highly desirable. Here, a one-pot electrooxidation method to synthesize formamide (HCONH 2 ) from methanol and ammonia over a commercial b oron- d oped d iamond (BDD) catalyst is reported. The formamide selectivity from methanol and formamide Faradaic efficiency (FE HCONH2 ) achieve 73.2% and 41.2% at the current density of 120 mA cm -2 with high durability. The C - N bond originates from the nucleophilic attack of ammonia on an aldehyde-like intermediate. Impressively, an 8 L electrolyzer is employed for the pilot plant test over a 2200 cm 2 BDD electrode, which exhibits 33.5% FE HCONH2 at 120 mA cm -2 (current: 264 A ) with a yield rate of 36.9 g h -1 , demonstrating the potential of this technique for large-scale electrosynthesis of formamide.

9.
Dis Markers ; 2022: 6943630, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072901

RESUMO

Objective: The objective of this study is to explore the effect of kartogenin (KGN-)-pretreated adipose-derived stem cell-derived exosomes (ADSC-EXOs) on the chondrogenic differentiation ability of ADSCs. Methods: Adipose-derived stem cells (ADSCs) were treated with different doses of KGN, and exosomes (EXOs) were extracted. EXOs were then identified using an electron microscope (EM), nanoparticle tracking analyzer, nanoparticle tracking analysis software, and exosomal protein markers. EXOs were labeled with the fluorescent dye PKH67 and their uptake by cells was evaluated. A cell counting kit-8 (CCK-8) assay, flow cytometry, clonogenic assay, and a cell scratch assay were used to detect the abilities of proliferation, apoptosis, clone formation, and migration of ADSCs, respectively. Subsequently, Alcian blue staining and toluidine blue staining were used to detect the chondrogenic differentiation ability of ADSCs in each group. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot (WB) techniques were used to detect the expression of chondrogenic differentiation-related genes. Results: In this study, ADSCs and KGN-induced ADSC-EXOs were successfully extracted and isolated. EXOs and ADSCs coculturing results showed that KGN-induced ADSC-EXOs can significantly promote proliferation, clone formation, migration, and chondrogenic differentiation of ADSCs and inhibit apoptosis. In addition, KGN-induced ADSC-EXOs can increase the expression of chondrogenic-related genes in ADSCs (Aggrecan, Collagen III, Collagen II, and SOX9), and can significantly decrease the expression of chondrolysis-related genes (MMP-3, ADAMTS4, and ADAMTS5). Conclusion: KGN-induced ADSC-EXOs can enhance the chondrogenic differentiation ability of ADSCs by promoting cell proliferation and migration while inhibiting cell apoptosis. KGN treatment can also increase the expression of chondrogenic differentiation-related genes and decrease the expression of chondrolysis-related genes. These results provide a new approach to cartilage repair and regeneration.


Assuntos
Exossomos , Adipócitos , Anilidas , Colágeno/metabolismo , Humanos , Ácidos Ftálicos , Células-Tronco/metabolismo
10.
J Affect Disord ; 2022 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-36084757

RESUMO

Dynamic functional network connectivity (dFNC) could capture temporal features of spontaneous brain activity during MRI scanning, and it might be a powerful tool to examine functional brain network alters in major depressive disorder (MDD). Therefore, this study investigated the changes in temporal properties of dFNC of first-episode, drug-naïve patients with MDD. A total of 48 first-episode, drug-naïve MDD patients and 46 age- and gender-matched healthy controls were recruited in this study. Sliding windows were implied to construct dFNC. We assessed the relationships between altered dFNC temporal properties and depressive symptoms. Receiver operating characteristic (ROC) curve analyses were used to examine the diagnostic performance of these altered temporal properties. The results showed that patients with MDD have more occurrences and spent more time in a weak connection state, but with fewer occurrences and shorter dwell time in a strong connection state. Importantly, the fractional time and mean dwell time of state 2 was negatively correlated with Hamilton Depression Rating Scale (HDRS) scores. ROC curve analysis demonstrated that these temporal properties have great identified power including the fractional time and mean dwell time in state 2, and the AUC is 0.872, 0.837, respectively. The AUC of the combination of fractional time and mean dwell time in state 2 with age, gender is 0.881. Our results indicated the temporal properties of dFNC are altered in first-episode, drug-naïve patients with MDD, and these changes' properties could serve as a potential biomarker in MDD.

11.
Biomacromolecules ; 2022 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-36059206

RESUMO

Mechanically adaptive materials responsive to environmental stimuli through changing mechanical properties are highly attractive in intelligent devices. However, it is hard to regulate the mechanical properties of most mechanically adaptive materials in a facile way. Moreover, it remains a challenge to achieve mechano-regulable materials with mechanical properties ranging from high strength to extreme toughness. Here, inspired by the reversible nanofibril network structure of skeletal muscle to achieve muscle strength regulation, we present a mechano-regulable biopolymeric silk fibroin (SF) composite through regulating dynamic metal-ligand coordination bonds by using water molecules as competitive regulators. Efficient interfacial hydrogen bonds between tannic acid-tungsten disulfide nanohybrids and the SF matrix endow the composite with high mechanical strength and self-healing ability. The resulting composite exhibits 837-fold change in Young's modulus (5.77 ± 0.61 GPa to 6.89 ± 0.64 MPa) after water vapor triggering, high mechanical properties (72.5 ± 6.3 MPa), and excellent self-healing efficiency (nearly 100%). The proof-of-concept ultraconformable iontronic skin and smart actuators are demonstrated, thereby providing a direction for future self-adaptive smart device applications.

12.
BMC Med ; 20(1): 279, 2022 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-36058909

RESUMO

BACKGROUND: Some occult hepatitis B virus (HBV) infections are resulted from PreS mutations that reduce secretion of envelope protein (HBsAg). We investigated the ceramide amounts and species in hepatocytes infected with PreS variants that were isolated from HBsAg-seronegative patients with hepatocellular carcinoma (HCC) and the ceramide effects on autochthonous HCC development in murine models. METHODS: HBV PreS/S regions from 35 HBsAg-seronegative HCC patients were sequenced. Hepatocyte cell lines and male C57BL/6J mouse livers were transfected with two PreS variant representatives. The ceramides with variated lengths of fatty acyl chains were quantified. Tumour development was examined in the HBV-transfected mice fed different diet types. RESULTS: In HBsAg-seronegative HCC patients, nonneoplastic liver tissues harboured HBsAg and replication-competent HBV. The most frequently detected PreS/S variants carried mutations of altered amino acid properties in HBsAg compared with an isolate from one HBsAg-seronegative HCC patient. Hepatocyte infection with PreS variants caused HBsAg retention within the endoplasmic reticulum and generated more amounts of ceramides with C16:0 ceramide elevated the highest. Saturated fatty acids aggravated the PreS variant-infected hepatocytes to generate abnormal amounts and species of ceramides, which with HBV proteins synergistically activated NLRP3 inflammasome in liver inflammatory macrophages. Liver tumours were only detected in HBV-transfected mice fed high-fat diet, with higher tumour loads in the PreS variant-transfected, associated with abnormal ceramide generation. CONCLUSIONS: HBV PreS mutations which altered amino acid properties of envelope proteins inhibited HBsAg secretion. Hepatocyte infection with PreS variants generated abnormal ceramides which with HBV proteins coactivated NLRP3 inflammasome in liver macrophages to promote autochthonous HCC development.


Assuntos
Carcinoma Hepatocelular , Hepatite B Crônica , Neoplasias Hepáticas , Aminoácidos/genética , Animais , Carcinoma Hepatocelular/genética , Ceramidas , Dieta Hiperlipídica/efeitos adversos , Antígenos de Superfície da Hepatite B/genética , Vírus da Hepatite B/genética , Inflamassomos , Neoplasias Hepáticas/genética , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Mutação , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética
13.
Nat Commun ; 13(1): 5452, 2022 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-36114196

RESUMO

Electrochemical conversion of abundant carbon- and nitrogen-containing small molecules into high-valued organonitrogen compounds is alluring to reducing current dependence on fossil energy. Here we report a single-cell electrochemical oxidation approach to transform methanol and ammonia into formamide under ambient conditions over Pt electrocatalyst that provides 74.26% selectivity from methanol to formamide and a Faradaic efficiency of 40.39% at 100 mA cm-2 current density, gaining an economic advantage over conventional manufacturing based on techno-economic analysis. A 46-h continuous test performed in the flow cell shows no performance decay. The combined results of in situ experiments and theoretical simulations unveil the C-N bond formation mechanism via nucleophilic attack of NH3 on an aldehyde-like intermediate derived from methanol electrooxidation. This work offers a way to synthesize formamide via C-N coupling and can be extended to substantially synthesize other value-added organonitrogen chemicals (e.g., acetamide, propenamide, formyl methylamine).

14.
Neuroreport ; 33(15): 656-662, 2022 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-36126263

RESUMO

OBJECTIVES: To determine the effects of astragaloside IV on cerebral ischemic-reperfusion injury in rats and to explore underlying mechanisms of brain protection. METHODS: Sixty Sprague-Dawley rats were randomized into four groups: Sham, cerebral ischemia-reperfusion (I/R group), I/R+astragaloside IV (I/R+AST-IV group) and I/R+astragaloside IV+PKA kinase inhibitor H-89 (I/R+AST-IV+H-89 group). All I/R rats were subjected to 2 h cerebral ischemia, followed by 24 h reperfusion and scored for neurobehavior. Cerebral infarct volume, pathomorphological changes and brain apoptosis, in addition to changes in expression of Cx36, PKA, Bax and Bcl-2 proteins, were assessed. RESULTS: Astragaloside IV treatment reduced neurobehavioral score and percentage volume of cerebral infarct, reducing pathomorphological injury and brain apoptosis. Expressions of Cx36 and PKA protein were increased and the Bax/Bcl-2 ratio decreased. All astragaloside IV effects were reversed by the PKA inhibitor and H-89. CONCLUSIONS: Astragaloside IV attenuated cerebral I/R injury in rats by increasing Cx36 and PKA protein expression and reducing the Bax/Bcl-2 ratio.


Assuntos
Isquemia Encefálica , Traumatismo por Reperfusão , Animais , Isquemia Encefálica/metabolismo , Infarto Cerebral , Isoquinolinas , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Ratos , Ratos Sprague-Dawley , Traumatismo por Reperfusão/tratamento farmacológico , Traumatismo por Reperfusão/metabolismo , Saponinas , Sulfonamidas , Triterpenos , Regulação para Cima , Proteína X Associada a bcl-2/metabolismo
15.
Front Microbiol ; 13: 1005657, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36118204

RESUMO

Appropriate hydrological management is critical for peatland restoration. An important prerequisite for peatland restoration is a recovery of soil biological processes. However, little is known about the effects of different hydrological management practices on soil biological processes during peatland restoration. In this study, the variations in soil properties, enzyme activities, and bacterial communities across different peatlands, namely natural peatland (NP), peatland restored under high water level (HR), peatland restored under alternating high-low water level (HLR), peatland restored under low water level (LR), and degraded peatland (DP), in the Changbai Mountains were investigated. Results showed that soil organic carbon, soil water content, and total nitrogen in NP were significantly higher than those in restored and degraded peatlands, and these soil properties in restored peatlands increased with the water level. The activities of soil hydrolases including ß-1, 4-glucosidase, ß-1, 4-n-acetylglucosidase, and acid phosphatase in NP were higher than in restored and degraded peatlands, while the activity of polyphenol oxidase in NP was the lowest. In restored peatlands, all measured enzyme activities decreased with the decline in water level. Both bacterial diversity and richness in NP were the lowest, while the highest diversity and richness were observed in HR. Redundancy analysis indicated that soil organic carbon, water level, soil water content, total nitrogen, and pH were the most important factors that affected the soil enzyme activities and bacterial community. Our findings give insight into the effects of different hydrological regimes on soil biological processes during peatland restoration. Maintaining a high water level early in the restoration process is more beneficial to restoring the ecological functions of peatlands than other hydrological regimes.

16.
Ann Surg Oncol ; 2022 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-36127527

RESUMO

BACKGROUND: Neoadjuvant chemoradiotherapy followed by esophagectomy is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC). This study explored correlations of clinical factors and dose-volume histogram (DVH) parameters with postoperative cardiopulmonary complications and predicted their risk by establishing a nomogram model. METHODS: Clinical and DVH parameters of ESCC patients who underwent trimodality treatment from 2002 to 2020 were collected. Postoperative cardiopulmonary complications were recorded. Logistic regression analysis was applied, and a nomogram model was constructed. Area under the receiver operating characteristic (AUC) curve, calibration curve, and decision curve analyses were performed to evaluate the performance of the nomogram. RESULTS: Of the 307 ESCC patients enrolled in this study, 65 (21.2%) experienced pulmonary complications and 57 (18.6%) experienced cardiac complications. The following six risk factors were identified as independent risk factors for pulmonary complications by multivariate logistic regression analyses in the integrated model: male sex (odds ratio [OR], 3.26; 95% confidence interval [CI], 1.27-9.70; P = 0.021), post-radiation therapy (RT) forced expiratory volume in 1 s (FEV1) (OR, 0.51; 95% CI 0.28-0.90; P = 0.023), mean lung dose (MLD) (OR, 1.13; 95% CI 1.01-1.28; P = 0.041), and pre-RT monocyte (OR, 8.36; 95% CI 1.23-11.7; P = 0.03). The AUC of this integrated model was 0.705 (95% CI 0.64-0.77). The paclitaxel and cisplatin (TP) concurrent chemotherapy regimen was the independent predictor of cardiac complication (OR, 2.50; 95% CI 1.22-5.55; P = 0.016). CONCLUSIONS: For ESCC patients who underwent trimodality treatment, male sex, post-RT FEV1, MLD, and pre-RT monocyte were confirmed as significant predictors of postoperative pulmonary complications. A nomogram model including six risk factors was further established. The independent predictor of cardiac complication was TP concurrent chemotherapy.

17.
J Food Biochem ; 46(9): e14371, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35933693

RESUMO

Polysaccharides derived from edible mushrooms were sources of new prebiotic compounds. Limited studies of their prebiotic effects, as well as the presence of residual dark colors, impede their use as prebiotics in the food industry. To boost the prebiotic value of polysaccharides from the edible mushroom Ramaria flava, a decolorization method, and the physicochemical characterization and prebiotic potential of the decolorized polysaccharide (DRFP) were investigated in this study. The reversed micelle system consisting of n-hexanol/isooctane (3:7, v/v) and 200 mM surfactant (CTAB) was an appropriate decolorized method for R. flava crude polysaccharide. That decolorized polysaccharide was 101.68 kDa and contained glucose, galactose, mannose, fucose, xylose, rhamnose, arabinose, and glucuronic acid in a ratio of 40.61:26.97:17.72:7.78:6.31:0.11:0.06:0.44. Furthermore, DRFP exhibited typical shear-thinning behavior and possessed good thermal stability. And 98.76% of DRFP was allowed to transit through the oral cavity and gastrointestinal tract nearly indigestibly in vitro fermentation. It also revealed a prebiotic availability through stimulating Lactobacillus rhamnosus proliferation and inducing enterocoel acidification. When utilized as a carbon source, DRFP significantly improves the production of short-chain fatty acids by L. rhamnosus, particularly acetic, propionic, isobutyric, and hexanoic acids. Therefore, this work suggests the further application of R. flava polysaccharides as emerging prebiotics, which may be used as an ingredient in functional food and nutraceutical products. PRACTICAL APPLICATIONS: Prebiotics could regulate gut microbial community and are closely associated with host health. This work reported that a decolorized polysaccharide (DRFP) prepared from the edible mushroom Ramaria flava was indigestible and could improve Lactobacillus rhamnosus proliferation and short-chain fatty acid production, which could provide useful information for the application of DRFP as a prebiotic additive in the food industry.


Assuntos
Agaricales , Basidiomycota , Agaricales/química , Polissacarídeos/química , Polissacarídeos/farmacologia , Prebióticos
18.
Insects ; 13(8)2022 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-36005308

RESUMO

Black soldier fly is a saprophagous insect that has been widely reported in recent years due to its excellent performance in bioremediation. Due to the widespread presence of flocculants in the organic waste treated by black soldier fly larvae, this study aimed to evaluate the potential impacts and risks of flocculant addition (a combination of poly aluminum chloride and polyacrylamide with the ratio of 50:1). Results showed that the growth and weight of BSFL in the high-exposure groups (≥200 mg/L) were inhibited. The bioaccumulation of aluminum (Al) in larvae was estimated, and the proportions of different Al forms in the frass from high to low were the residual state (41.38% to 67.92%), water-soluble state (16.88% to 37.03%), acid-soluble state (8.45% to 18.72%), and alkali-soluble state (3.38% to 5.14%). The relative abundance of bacterial genera related to lipid metabolism decreased with increasing flocculant concentrations while disease-related taxa increased in relative abundance. The results serve as a reference for subsequent research and application of the treatment of flocculant-contaminated waste by BSFL.

19.
Comput Intell Neurosci ; 2022: 3448182, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36035839

RESUMO

Objective: A case-control study explored the application of case-based teaching methods in the clinical teaching of radiology. Materials and Methods: 126 radiology interns of grade 2018 were selected by cluster sampling and randomly divided into the research group and the control group. The traditional teaching approach was used in the control group and the primary teaching principle was used in the research group. The teaching effects of the two groups were compared. Results: The interns' test scores, the research group's case summary multiple-choice questions, case-group multiple-choice questions, case analysis questions, theoretical total scores, and practical operation assessment scores were significantly higher than those of the control group, and the difference was statistically significant (P < 0.05). The total score of dimensions of the interns' critical thinking ability in the study group were significantly higher than those in the control group, and the difference was statistically significant (P < 0.05). The interns' perception of teachers, students' academic self-perception, students' perception of environment, students' social self-perception, and the total score of the DREEM scale in the study group were considerably greater than those in the control group, and the difference was statistically significant (P < 0.05). After teaching, the scores of systematic thinking ability and evidence-based thinking ability of the interns were significantly increased. The improvement in the study group was more significant than that in the control group, and the difference was statistically significant (P < 0.05). Following teaching, the scores of learning interest, self-management, plan implementation, and mutual cooperation of the interns in the two groups were significantly upregulated, and the difference was statistically significant (P < 0.05). Among them, the improvement of interns' abilities in the research group was significantly better than that in the control group, and the difference was statistically significant (P < 0.05). The scores of learning goal, learning process, learning effect, classroom environment construction, teaching strategy, and technology application in the research group were greater than those in the control group, and the difference was statistically significant (P < 0.05). The satisfaction rate of the study group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion: The application of the case teaching method based on primary teaching principle in the radiology clinical teaching course is helpful to cultivate students' critical thinking ability and improve students' performance and classroom teaching effectiveness.


Assuntos
Radiologia , Estudos de Casos e Controles , Humanos , Aprendizagem , Estudantes , Ensino
20.
Comput Math Methods Med ; 2022: 6808648, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35991150

RESUMO

Objective: To study the application value of PBL (Problem-Based Learning) combined with a situational simulation teaching method in clinical practice teaching of radiology. Methods: 120 interns who practiced in the radiology department of our hospital from 2020 to 2021 were randomly divided into a study group and a control group. The research group used PBL combined with the scenario simulation teaching method to carry out clinical practice teaching activities. The control group was carried out according to the conventional teaching plan. After 3 months, the teaching effect and satisfaction of the two groups were compared. Results: The imaging report quality control score, intravenous contrast agent score, and practice test score in the study group were higher than those in the control group. The scores of the small class and special class in the research group were higher than those in the control group, and the difference was statistically significant (P < 0.05). The scores of job competency questionnaire in the research group were higher than those in the control group (P < 0.05). The occupational self-efficacy questionnaire score of the research group was higher than that of the control group (P < 0.05). The nursing practice satisfaction score of the research group was higher than that of the control group (P < 0.05). Conclusion: The value of PBL combined with the scenario simulation teaching method in the teaching of radiology clinical practice is significant, which can improve the work ability of interns and make them more satisfied.


Assuntos
Aprendizagem Baseada em Problemas , Radiologia , Humanos , Aprendizagem Baseada em Problemas/métodos , Inquéritos e Questionários
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