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1.
Chemistry ; 2022 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-34982835

RESUMO

Separation of xylene isomers is one of the most important but most challenging and energy-intensive separation processes in the petrochemical industry. Here, we report an adaptive hydrogen-bonded organic framework (HOF-28) constructed from a porphyrin based organic building block 4,4',4'',4'''-(porphyrin-5,10,15,20-tetrayl) tetrabenzonitrile (PTTBN), exhibiting the exclusive molecular recognition of p-xylene (pX) over its isomers of o-xylene (oX) and m-xylene (mX), as clearly demonstrated in the single crystal structure transformation and 1H NMR studies. Single crystal structure studies show that single-crystal-to-single-crystal transformation from the as-synthesized HOF-28 to the pX exclusively included HOF-28ÉpX is triggered by the encapsulation of pX molecules, accompanied by sliding of the 2D layers and local distortion of the ligand, which provides multiple C-H·· π interactions.

2.
Langmuir ; 38(1): 523-530, 2022 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-34932356

RESUMO

Solar-driven CO2 conversion to carbon-based fuels is an attractive approach to alleviate the worsening global climate change and increasing energy issues. However, exploring and designing efficient photocatalysts with excellent activity and stability still remain challenging. Herein, layered Li1.81H0.19Ti2O5·2H2O (LHTO) nanosheets were explored as the photocatalyst for photocatalytic CO2 reduction, and atomically thin LHTO nanosheets with one-unit-cell thickness were successfully constructed for photocatalytic CO2 reduction. The atomically thin LHTO nanosheets exhibited excellent performance for CO2 photoreduction to CO, with a yield rate of 4.0 µmol g-1 h-1, a selectivity of 93%, and over 25 h photostability, dramatically outperforming the bulk LHTO. The better performance of the atomically thin LHTO nanosheets was experimentally verified to benefit from more sites for CO2 adsorption, faster electron transfer rate, and a more negative conduction band edge compared with bulk LHTO. This work provided a methodological basis for designing more efficient photocatalytic CO2 reduction catalysts.

3.
J Colloid Interface Sci ; 608(Pt 1): 219-226, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34626968

RESUMO

Riboflavin (RF) is one of the necessary vitamins. If human body lacks RF, it will lead to inflammation and dysfunction of mouth, lips and skin. Thus sensitive and accurate determination of RF is necessary. Here, an electroactive covalent-organic framework nanobelt (COFTFPB-Thi) with thickness of 1.4 nm was prepared by amine-aldehyde condensation reaction between thionine and 1, 3, 5-tris (p-formylphenyl) benzene, which was then grown vertically on three-dimensional porous carbon derived from kenaf stem (3D-KSC) for double signal ratiometric electrochemical detection of RF. The resulted 3D-KSC/COFTFPB-Thi showed two reduction peaks at -0.08 V and -0.23 V, which came from the reduction of COFTFPB-Thi and the conjugated structure of COFTFPB-Thi, respectively. In the presence of RF, those RF molecules near the electrode surface were oxidized at 0.6 V. Then some oxidized RF (RFox) adsorbed on COFTFPB-Thi would oxidize COFTFPB-Thi into COFTFPB-Thi(ox) while other RFox adsorbed on 3D-KSC kept unchanged. When the potential was scanned from 0.6 V to -0.6 V, both COFTFPB-Thi(ox) and RFox adsorbed on 3D-KSC were reduced at -0.08 V and -0.45 V accordingly, while the reduction peak of -0.23 V of the conjugated structure of COFTFPB-Thi kept constant. When j-0.45/j-0.23 was used as the response signal, the detection limit was 44 nM and the linear range was 0.13 µM -0.23 mM. By using j-0.08/j-0.23 as the response signal, a detection limit of 90 nM and a linear range of 0.30 µM-0.23 mM (S/N = 3) were obtained. By using double signals, the measurement results can be corrected to make the results more accurate and reliable. The sensor also showed good selectivity, reproducibility and stability, which provided a good application prospects.


Assuntos
Técnicas Biossensoriais , Estruturas Metalorgânicas , Carbono , Técnicas Eletroquímicas , Eletrodos , Ouro , Humanos , Limite de Detecção , Fenotiazinas , Reprodutibilidade dos Testes , Riboflavina
4.
Methods Mol Biol ; 2400: 275-282, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34905210

RESUMO

Plant virus infections cause damages to all kinds of crops, and result in enormous economic and yield losses worldwide. Numerous reports indicated that many plant viruses are vertically transmitted through seeds, and cause severe disease symptoms on seedlings that again serve as secondary transmission sources in fields. Therefore, it is necessary to develop efficient methods to detect the seeds infected by viruses. Here, we describe a RT-PCR protocol for detection of Cucumber green mottle mosaic virus (CGMMV), a tobamovirus in cucurbitaceous crop seeds. This method can be easily adapted for diagnosis of other plant viruses such as Tomato brown rugose fruit virus in seeds.

5.
J Am Heart Assoc ; 11(1): e022607, 2022 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-34970912

RESUMO

Background The effect of serum growth differentiation factor 15 (GDF-15) on poststroke depression (PSD) remains unknown. This study aimed to investigate the association between serum GDF-15 and PSD among patients with ischemic stroke. Methods and Results This study was based on a random sample from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). A total of 572 patients from 7 participating hospitals with GDF-15 levels were included in this analysis. The study outcome was depression (Hamilton Depression Rating Scale score ≥8) at 3 months after ischemic stroke. A total of 231 (40.4%) patients with stroke experienced PSD within 3 months. The multivariate-adjusted odds ratio of PSD associated with the highest tertile of serum GDF-15 was 2.92 (95% CI, 1.36-6.27) compared with the lowest tertile. Each SD increase in log-transformed GDF-15 was associated with a 42% (95% CI, 2%-97%) increased risk of PSD, and a linear association between serum GDF-15 and the risk of PSD was observed (P for linearity=0.006). Conclusions Elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.

6.
Int J Therm Sci ; 172: 107371, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34785972

RESUMO

A cooperative control strategy is proposed for the air conditioning (AC) system and ventilation system to reduce the risk of COVID-19 infection and save the energy of the AC system. This strategy integrates the dynamic model of the AC-cabin system, infection risk assessment, model predictive control (MPC) of the thermal environment inside the cabin, and ventilation control that considers passengers' sneezing. Unlike other existing AC system models, the thermal-health model established can describe not only the system performance but also the virus concentration and risk of COVID-19 infection using the Wells-Riley assessment model. Experiments are conducted to verify the prediction accuracy of the AC-cabin model. The results prove that the proposed model can accurately predict the evolution of cabin temperature under different cases. The cooperative control strategy of the AC system integrates the MPC-based refrigeration algorithm for the cabin temperature and intermittent ventilation strategy to reduce the risk of COVID-19 infection. This strategy well balances the control accuracy, energy consumption of the AC system, and the risk of COVID-19 infection, and greatly reduces the infection risk at the expense of a little rise in the energy consumption.

7.
World J Clin Cases ; 9(31): 9481-9490, 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34877282

RESUMO

BACKGROUND: The novel coronavirus disease 2019 (COVID-19) has spread widely around the world with strong infectivity, rapid mutation and a high mortality rate. Mechanical ventilation has been included in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 8) as an important treatment for severe and critical COVID-19 patients, but its clinical efficacy in COVID-19 patients is various. Therefore, it is necessary to study the influencing factors on the efficacy of mechanical ventilation in severe and critical COVID-19 patients. AIM: The aim of this study was to determine the influencing factors on the efficacy of mechanical ventilation in severe and critical COVID-19 patients. METHODS: A total of 27 severe and critical COVID-19 patients were enrolled in this study and treated with mechanical ventilation at the Optical Valley Campus of Hubei Maternal and Child Health Care Hospital (Wuhan, Hubei Province) from February 20, 2020 to April 5, 2020. According to the final treatment outcomes, the patients were divided into the "effective group" and "death group." The clinical data of the two groups, such as the treatment process and final outcome, were retrospectively analyzed in order to determine the specific curative effects on the two groups and the reasons for the differences in such curative effects, as well as to explore the factors related to death. RESULTS: This study enrolled 27 severe and critical COVID-19 patients, including 17 males (63.0%) and 10 females (37.0%). Their ages were 74.41 ± 11.73-years-old, and 19 patients (70.4%) were over 70-years-old. Severe COVID-19 patients over 70-years-old who were treated with mechanical ventilation died in 14 cases (82.4%); thus, this was the peak age. A total of 17 patients died of basic disease, 16 of whom had more than two basic diseases. The basic diseases were hypertension, diabetes, and cardiovascular and cerebrovascular diseases. At the same time, 13 patients (76.5%) died from an abnormal increase in blood glucose. Among them, eight had diabetes before contracting COVID-19 and five had a stress-induced increase in blood glucose after contracting COVID-19. Diabetic ketoacidosis occurred in one case. The use of tocilizumab may be a double-edged sword that carries a certain risk in clinical usage. Among the patients who died, 16 (94.1%) went into septic shock at the end. There were significant differences in the degree of infection, cardiac and renal function, and blood glucose between the death group and effective group. CONCLUSION: Age, blood glucose, cardiac and renal function, and inflammatory reaction are important indicators of poor prognosis for mechanical ventilation in severe and critical COVID-19 patients.

8.
Inorg Chem ; 2021 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-34870966

RESUMO

A copper-based metal-organic framework, [Cu2(PBTDA)(H2O)2] (UTSA-98, UTSA = the University of Texas at San Antonio; H4PBTDA = 5',5''''-(1,4-phenylene)bis([1,1':3',1″-terphenyl]-4,4″-dicarboxylic acid)), has been solvothermally synthesized. The alternative connection of classical dicopper secondary building units and deprotonated four-branched PBTDA4- ligands led to the formation of the three-dimensional framework of UTSA-98 with one-dimensional rhombic channels. Its guest-free phase, UTSA-98a, uptakes much more C2H2 (82.6 cm3/g) than CO2 (40.3 cm3/g) at 298 K and 100 kPa, resulting in a high adsorption selectivity of 5.2. Furthermore, the efficient separation ability of UTSA-98a toward the C2H2/CO2 gas mixture was further verified by laboratory-scale fixed-bed breakthrough experiments.

9.
Neoplasma ; 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-34881630

RESUMO

Stanniocalcin 2 (STC2) has been identified as a prognostic marker in renal cell carcinoma. However, the role of STC2 in renal cell carcinoma is still unclear. In this study, we investigated the relationship between high expression of STC2 and sunitinib resistance in cells and the underlying mechanism. Through GEPIA platform analysis based on the TCGA database, it showed that the expression of STC2 in kidney renal clear cell carcinoma (KIRC) was significantly higher than that in the normal population. Real-time quantitative PCR and western blotting detected significantly higher expression levels of STC2 in clear cell renal cell carcinoma (ccRCC) cells than that in normal renal cells. Enzyme-linked immunosorbent assay (ELISA) determined whether there is a high secretion of STC2 in ccRCC cells. The sunitinib resistance could be significantly reduced by STC2 neutralizing antibody but aggravated by the addition of recombinant human STC2 in ccRCC cells. Sunitinib suppressed STC2 expression and secretion, destroyed lysosomal acidic pH, and accumulated in the cells. However, STC2 neutralizing antibody can reduce the accumulation of sunitinib in cells to improve the inhibitory efficiency of sunitinib on cell proliferation. This study suggested STC2 could serve as a potential novel target for the treatment of ccRCC, anti-STC2 antibody might be an option of immunotherapy in the future.

10.
Nat Commun ; 12(1): 7179, 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-34893592

RESUMO

During lung fibrosis, the epithelium induces signaling to underlying mesenchyme to generate excess myofibroblasts and extracellular matrix; herein, we focus on signaling in the mesenchyme. Our studies indicate that platelet-derived growth factor receptor (PDGFR)-ß+ cells are the predominant source of myofibroblasts and Kruppel-like factor (KLF) 4 is upregulated in PDGFR-ß+ cells, inducing TGFß pathway signaling and fibrosis. In fibrotic lung patches, KLF4 is down-regulated, suggesting KLF4 levels decrease as PDGFR-ß+ cells transition into myofibroblasts. In contrast to PDGFR-ß+ cells, KLF4 reduction in α-smooth muscle actin (SMA)+ cells non-cell autonomously exacerbates lung fibrosis by inducing macrophage accumulation and pro-fibrotic effects of PDGFR-ß+ cells via a Forkhead box M1 to C-C chemokine ligand 2-receptor 2 pathway. Taken together, in the context of lung fibrosis, our results indicate that KLF4 plays opposing roles in PDGFR-ß+ cells and SMA+ cells and highlight the importance of further studies of interactions between distinct mesenchymal cell types.

11.
Nano Lett ; 21(24): 10368-10376, 2021 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-34898228

RESUMO

Selective partial photooxidation of CH4 into value-added chemicals under mild conditions still remains a huge bottleneck. Herein, we design positively charged metal clusters anchored on a three-dimensional porous carbon aerogel. With 0.75FeCA800-4 as an example, X-ray photoelectron spectra and Raman spectra disclose that the iron sites are positively charged. In situ electron paramagnetic resonance spectra show that the Feδ+ sites could donate electrons to activate CH4 into CH4- by virtue of the excited-state carbon atoms; meanwhile, they could convert H2O2 into •OH radicals under irradiation. In addition, in situ diffuse Fourier-transform infrared spectra suggest the CH3OOH obtained is derived from CH4 oxidation by the hydroxylation of *CH3 and *CH3O intermediates. Consequently, 0.75FeCA800-4 displays a CH3OOH selectivity of near 100% and a CH3OOH evolution rate of 13.2 mmol gFe-1 h-1, higher than those of most previously reported supported catalysts under similar conditions.

12.
Artigo em Inglês | MEDLINE | ID: mdl-34925533

RESUMO

Background: Cancer-related fatigue (CRF) is an increasingly appreciated complication in cancer patients, which severely impairs their quality of life for a long time. Astragali Radix (AR) is a safe and effective treatment to improve CRF, but the related mechanistic studies are still limited. Objective: To systematically analyze the mechanism of AR against CRF by network pharmacology. Methods: TCMSP was searched to obtain the active compounds and targets of AR. The active compound-target (AC-T) network was established and exhibited by related visualization software. The GeneCards database was searched to acquire CRF targets, and the intersection targets with AR targets were used to make the Venny diagram. The protein-protein interaction (PPI) network of intersection targets was established, and further, the therapeutic core targets were selected by topological parameters. The selected core targets were uploaded to Metascape for GO and KEGG analysis. Finally, AutoDock Vina and PyMOL were employed for molecular docking validation. Results: 16 active compounds of AR were obtained, such as quercetin, kaempferol, 7-O-methylisomucronulatol, formononetin, and isorhamnetin. 57 core targets were screened, such as AKT1, TP53, VEGFA, IL-6, and CASP3. KEGG analysis manifested that the core targets acted on various pathways, including 137 pathways such as TNF, IL-17, and the AGE-RAGE signaling pathway. Molecular docking demonstrated that active compounds docked well with the core targets. Conclusion: The mechanism of AR in treating CRF involves multiple targets and multiple pathways. The present study laid a theoretical foundation for the subsequent research and clinical application of AR and its extracts against CRF.

13.
Front Cell Infect Microbiol ; 11: 765504, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34926317

RESUMO

Background: Total laboratory automation (TLA) has the potential to reduce specimen processing time, optimize workflow, and decrease turnaround time (TAT). The purpose of this research is to investigate whether the TAT of our laboratory has changed since the adoption of TLA, as well as to optimize laboratory workflow, improve laboratory testing efficiency, and provide better services of clinical diagnosis and treatment. Materials and Methods: Laboratory data was extracted from our laboratory information system in two 6-month periods: pre-TLA (July to December 2019) and post-TLA (July to December 2020), respectively. Results: The median TAT for positive cultures decreased significantly from pre-TLA to post-TLA (65.93 vs 63.53, P<0.001). For different types of cultures, The TAT of CSF changed the most (86.76 vs 64.30, P=0.007), followed by sputum (64.38 vs 61.41, P<0.001), urine (52.10 vs 49,57, P<0.001), blood (68.49 vs 66.60, P<0.001). For Ascites and Pleural fluid, there was no significant difference (P>0.05). Further analysis found that the incidence of broth growth only for pre-TLA was 12.4% (14/133), while for post-TLA, it was 3.4% (4/119). The difference was statistically significant (P=0.01). The common isolates from CSF samples were Cryptococcus neoformans, coagulase-negative Staphylococcus, Acinetobacter baumannii, and Klebsiella pneumonia. Conclusion: Using TLA and setting up three shifts shortened the TAT of our clinical microbiology laboratory, especially for CSF samples.

14.
Front Vet Sci ; 8: 773912, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34926645

RESUMO

Porcine circovirus type 3 (PCV3), a virus belonging to the Circoviridae family, is considered to be associated with respiratory and neurological signs, cardiac and multisystemic inflammation, reproductive failure, and porcine dermatitis and nephropathy syndrome-like disease in pigs (Sus scrofa). In this study, epidemiological and serological investigations of PCV3 in clinically healthy pigs from different regions of China were performed. Overall, 42.87% (1,101/2,568) of pigs were positive for PCV3 Cap antibody via indirect enzyme-linked immunosorbent assay, with a higher prevalence of PCV3 in multiparous sows (62.22%, 881/1,416) and fattening pigs (28.96%, 159/549) than in suckling piglets (8.96%, 32/357) and nursery pigs (11.79%, 29/246). Of the 2,568 samples, 255 were further tested for PCV3 DNA using real-time polymerase chain reaction, and 63.14% of these were positive, with nearly half having <10 virus copies. The PCV3 DNA and antibody positivity rates were high in the pig serum samples; however, the virus titers and antibody levels were both low, indicating that the humoral immune response of PCV3-infected pigs was weak or lagging, and persistent or repeated infections could occur. Additionally, the complete genomes of 23 PCV3 strains were sequenced and analyzed, which showed nucleotide identities of 98.5~100.0%, 98.6~100.0%, and 99.2~100.0% in the complete genome, open reading frame (ORF)2, and ORF1 sequences, respectively, and amino acid identities of 96.7~100.0% and 99.3~100.0% in the capsid and replicase proteins, respectively. Phylogenetic analysis based on ORF2 nucleotide sequences indicated that the PCV3 strains obtained in the present study could be classified into three sub-clades, with most strains clustered into clade 3c, indicating that PCV3c is the dominant subtype in the regions of China investigated. In general, the present study revealed a high prevalence and high genetic divergence of PCV3 among Chinese pig herds, and indicated that the potential effect of PCV3 on the pig industry may be a concern.

15.
Phys Rev Lett ; 127(24): 244501, 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-34951813

RESUMO

An important and unresolved issue in rotating thermal turbulence is when the flow starts to feel the centrifugal effect. This onset problem is studied here by a novel experiment in which the centrifugal force can be varied over a wide range at fixed Rossby numbers by offsetting the apparatus from the rotation axis. Our experiment clearly shows that the centrifugal force starts to separate the hot and cold fluids at the onset Froude number 0.04. Additionally, this flow bifurcation leads to an unexpected heat transport enhancement and the existence of an optimal state. Based on the dynamical balance and characteristics of local flow structures, both the onset and optimal states are quantitatively explained.

16.
Curr Med Sci ; 41(6): 1123-1133, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34950987

RESUMO

Chronic diseases are a growing concern worldwide, with nearly 25% of adults suffering from one or more chronic health conditions, thus placing a heavy burden on individuals, families, and healthcare systems. With the advent of the "Smart Healthcare" era, a series of cutting-edge technologies has brought new experiences to the management of chronic diseases. Among them, smart wearable technology not only helps people pursue a healthier lifestyle but also provides a continuous flow of healthcare data for disease diagnosis and treatment by actively recording physiological parameters and tracking the metabolic state. However, how to organize and analyze the data to achieve the ultimate goal of improving chronic disease management, in terms of quality of life, patient outcomes, and privacy protection, is an urgent issue that needs to be addressed. Artificial intelligence (AI) can provide intelligent suggestions by analyzing a patient's physiological data from wearable devices for the diagnosis and treatment of diseases. In addition, blockchain can improve healthcare services by authorizing decentralized data sharing, protecting the privacy of users, providing data empowerment, and ensuring the reliability of data management. Integrating AI, blockchain, and wearable technology could optimize the existing chronic disease management models, with a shift from a hospital-centered model to a patient-centered one. In this paper, we conceptually demonstrate a patient-centric technical framework based on AI, blockchain, and wearable technology and further explore the application of these integrated technologies in chronic disease management. Finally, the shortcomings of this new paradigm and future research directions are also discussed.

17.
Curr Med Sci ; 41(6): 1158-1164, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34971441

RESUMO

OBJECTIVE: To explore a new artificial intelligence (AI)-aided method to assist the clinical diagnosis of tibial plateau fractures (TPFs) and further measure its validity and feasibility. METHODS: A total of 542 X-rays of TPFs were collected as a reference database. An AI algorithm (RetinaNet) was trained to analyze and detect TPF on the X-rays. The ability of the AI algorithm was determined by indexes such as detection accuracy and time taken for analysis. The algorithm performance was also compared with orthopedic physicians. RESULTS: The AI algorithm showed a detection accuracy of 0.91 for the identification of TPF, which was similar to the performance of orthopedic physicians (0.92±0.03). The average time spent for analysis of the AI was 0.56 s, which was 16 times faster than human performance (8.44±3.26 s). CONCLUSION: The AI algorithm is a valid and efficient method for the clinical diagnosis of TPF. It can be a useful assistant for orthopedic physicians, which largely promotes clinical workflow and further guarantees the health and security of patients.

18.
Adv Sci (Weinh) ; : e2104234, 2021 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-34825524

RESUMO

Cyanide is the simplest ligand with strong basicity to construct open frameworks including some of the oldest compounds reported in the history of coordination chemistry. Cyanide can form numerous cyanometallates with different transition metal ions showing diverse geometries. Rational design of robust extended networks is enabled by the strong bonding nature and high directionality of cyanide ligand. By virtue of a combination of cyanometallates and/or organic linkers, multifunctional framework materials can be targeted and readily synthesized for various applications, ranging from molecular adsorptions/separations to energy conversion and storage, and spin-crossover materials. External guest- and stimuli-responsive behaviors in cyanide-based materials are also highlighted for the development of the next-generation smart materials. In this review, an overview of the recent progress of cyanide-based multifunctional materials is presented to demonstrate the great potential of cyanide ligands in the development of modern coordination chemistry and material science.

19.
BMC Neurol ; 21(1): 461, 2021 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-34836497

RESUMO

BACKGROUND: Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential diagnosis and treatment, which may aggravate the disease, increase the recurrence rate and mortality. The coexistence of anti-Leucinie-rich Glioma Inactivated 1 (LGI1) and anti-γ-aminobutyric acid-beta-receptor 1 (GABABR1) has not been published before. CASE PRESENTATION: We herein present the case of a 60-year-old man with slow response, behavioral changes, psychosis and sleep disorders. Laboratory test included serum hyponatremia, positive serum LGI1 and GABABR1 antibodies using transfected cell-based assays. Electroencephalogram exhibited moderate diffusion abnormality. The patient responded well to steroid impulse treatment and sodium supplement therapy, and did not recur during the follow-up. CONCLUSIONS: Here we report the first AE characterized by positive LGI1 and GABABR1 antibodies, as well as summarizing AE with multiple auto-antibodies reported so far, hopefully to provide experience for clinical practice.


Assuntos
Glioma , Encefalite Límbica , Autoanticorpos , Encefalite , Doença de Hashimoto , Humanos , Peptídeos e Proteínas de Sinalização Intracelular , Masculino , Pessoa de Meia-Idade
20.
Chem Commun (Camb) ; 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34787130

RESUMO

3D Pd aerogels with a controllable homojunction density are synthesized using an innovative melting-casting technology. The homojunction-rich Pd aerogels selectively reduce CO2 to CO with a 92.3% faradaic efficiency and durability over 10 h, benefiting from the strong coupling between the electrons and the adsorbed intermediates at the phase-mismatch interface.

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