Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.355
Filtrar
1.
Food Chem ; 402: 134228, 2023 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-36130435

RESUMO

Considering the importance of rapid and effective detection of nitrite in food samples, herein, we report a multistep heterophase synthetic strategy for constructing crystalline-amorphous zinc/cobalt iron porous nanosheets (C-A Zn/Co-Fe PNSs) on carbon cloth. Notably, the C-A Zn/Co-Fe PNSs@CC electrochemical interface consists of interlaced carbon fibers with many uniformly distributed hybrid nanosheets containing crystalline-amorphous interfacial sites. This particular hybrid structure permits local enrichment of nitrite for enhanced nitrite capture efficiency, laying a solid foundation for the ultrasensitive detection of nitrite. In proof-of-concept experiments, we verified that C-A Zn/Co-Fe PNSs@CC could be used to analyze nitrite with good sensitivity and reproducibility. It is worth mentioning that an ultra-low LOD of 0.44 µM was obtained for the detection of nitrite. The designed electrochemical sensor worked well in complex samples such as sausages and tap water under optimal parameters.


Assuntos
Carbono , Nitritos , Fibra de Carbono , Reprodutibilidade dos Testes , Carbono/química , Cobalto/química , Água , Ferro/química , Zinco/química
2.
J Colloid Interface Sci ; 631(Pt A): 245-259, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36379083

RESUMO

HYPOTHESIS: In a porous medium saturated with oil (containing oleic surfactant) and saline water, salinity reduction alters the thermodynamic equilibrium and induces spatial redistribution of surfactants, changing the local fluid configuration. During fluid-fluid displacement, this local change reshapes global fluid flows, and thus results in improved oil displacement. EXPERIMENTS: We performed microfluidic experiments in a centimeter-long pore-network model with a fracture and a dead-end model to observe both the macroscale flows and microscopic fluid configuration evolution. Water with different salinities and model oils with different surfactant concentrations are used. FINDINGS: When oil contacts low salinity water, we observe (1) the solid surface becomes more water-wet, and (2) water-in-oil emulsion spontaneously emerges near the oil-water interface. At the macroscale, the fluid distribution remains unchanged in short term but dramatically changes after tens of hours, which appears as improved oil recovery. Two modes are identified during fluid redistribution: gradual imbibition and sudden collapse. The displacement efficiency is a non-monotonic function of surfactant concentration. This is attributed to the interplay between two opposing effects by adding surfactant: (1) enhancing initial hydrophobicity which negatively affects the displacement, and (2) allowing stronger oil swelling which is beneficial for displacement.


Assuntos
Águas Salinas , Salinidade , Tensoativos , Óleos , Porosidade
3.
Artigo em Inglês | MEDLINE | ID: mdl-36031163

RESUMO

BACKGROUND: Previous neuroimaging has paid little attention to the differences in brain network integration between patients with treatment-resistant depression(TRD) and non-TRD (nTRD), and the relationship between their impaired brain network integration and clinical symptoms has not been elucidated. METHOD: Eighty one major depressive disorder (MDD) patients (40 in TRD, 41 in nTRD) and 40 healthy controls (HCs) were enrolled for the functional magnetic resonance imaging (fMRI) scans. A seed-based functional connectivity (FC) method was used to investigate the brain network abnormalities of default mode network (DMN), affective network (AN), salience network (SN) and cognitive control network (CCN) for the MDD. Finally, the correlation was analyzed between the abnormal FCs and 17-item Hamilton Rating Scale for Depression scale (HAMD-17) scores. RESULTS: Compared with the HC group, the FCs in DMN, AN, SN, CCN were altered in both the TRD and nTRD groups. Compared with the nTRD group, FC alterations in the AN and CCN were more abnormal in the TRD group, and the FC alterations were generally decreased at the SN in the TRD group. In addition, the FC values of right dorsolateral prefrontal cortices and left caudate nucleus in the TRD group and the FC values of right subgenual anterior cingulate cortex and left middle temporal gyrus in the nTRD group were positively correlated with HAMD-17 scale scores. CONCLUSIONS: Abnormal FCs are present in four brain networks (DMN, AN, SN, CCN) in both the TRD and nTRD groups. Except of DMN, FCs in AN, SN and CCN maybe underlay the neurobiological mechanism in differentiating TRD from nTRD.


Assuntos
Mapeamento Encefálico , Transtorno Depressivo Maior , Humanos , Transtorno Depressivo Maior/diagnóstico por imagem , Depressão , Encéfalo/diagnóstico por imagem , Imageamento por Ressonância Magnética
4.
J Environ Sci (China) ; 124: 360-370, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36182145

RESUMO

Efficient and robust photocatalysts for environmental pollutants removal with outstanding stability have great significance. Herein, we report a kind of three dimensional (3D) photocatalyst presented as Z-scheme heterojunction, which combining TiO2 and ZnxCd1-xS with graphene aerogel to contrast TiO2-ZnxCd1-xS graphene aerogel (TSGA, x=0.5) through a moderate hydrothermal process. The as-prepared Z-scheme TSGA was used to remove aqueous Cr(VI) via a synergistic effect of adsorption and visible light photocatalysis. The adsorption equilibrium can be reached about 40 min, then after about 30 min irradiation under visible light (wavelength (λ) > 420 nm) the removal rate of Cr(VI) almost reached 100%, which is much better than the performance of pristine TiO2 and Zn0.5Cd0.5S, as well as TiO2 graphene aerogel (TGA) and Zn0.5Cd0.5S graphene aerogel (SGA). The virulent Cr(VI) was reduced to Cr(III) with hypotoxicity after photocatalysis on TSGA, meanwhile the as-synthesized TSGA presented a good stability and reusability. The reduced graphene oxide (rGO) sheets between TiO2 and Zn0.5Cd0.5S played a role as charge transfer mediator, promoting the photoinduced electrons transfer and photocatalysis ability of TSGA was enhanced significantly. Hence, such photocatalyst exhibits a potential application on removing heavy metals with high efficiency and stability from polluted aqueous environment.

5.
Front Pharmacol ; 13: 807651, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35370667

RESUMO

Overview: The treatment of chronic renal failure (CRF) with traditional Chinese medicine has attracted much attention, but its mechanism is not clear. Network pharmacology is an effective strategy for exploring the interaction mechanisms between Chinese herbs and diseases, however, it still needs to be validated in cell and/or animal experiments due to its virtual screening characteristics. Herein, the anti-CRF mechanism of the Fushengong decoction (FSGD) was investigated using a dual-dimension network pharmacological strategy combined with in vivo experiment. Methods: The traditional Chinese medicine systems pharmacology (TCMSP) database (https://tcmspw.com) and UHPLC-MS/MS technology were used to identify the effective compounds of FSGD in theory and practice, such as quercetin, formononetin, and pachymic acid. The putative targets of FSGD and CRF were obtained from the Swisstarget prediction platform and the Genecards database, respectively. The common target pathways between FSGD and CRF were got from the dual-dimension network pharmacology analysis, which integrated the cross-common targets from the TCMSP components-Swisstarget-Genecards-Venn platform analysis in theory, and the UHPLC-MS/MS identified effective ingredients-Swisstarget screening, such as TNF and PI3K/AKT. Furthermore, system molecular determinations were used to prove the dual-dimension network pharmacology study through CRF rat models, which were constructed using adenine and treated with FSGD for 4 weeks. Results: A total of 121 and 9 effective compounds were obtained from the TCMSP database and UHPLC-MS/MS, respectively. After dual-dimension network pharmacology analysis, the possible mechanism of PTEN/PI3K/AKT/NF-κB pathway was found for FSGD in CRF. In vivo experiments indicated that FSGD can play a role in protecting renal function and reducing fibrosis by regulating the PTEN/PI3K/AKT/NF-κB pathway. These findings provide a reference for FSGD in CRF. Conclusion: Based on the theoretical and practical dual-dimension network pharmacology analysis for FSGD in CRF, the possible molecular mechanism of PTEN/PI3K/AKT/NF-κB was successfully predicted, and these results were verified by in vivo experiments. In this study, the dual-dimension network pharmacology was used to interpret the key signal pathway for FSGD in CRF, which also proved to be a smart strategy for the study of effective substances and pharmacology in FSGD.

6.
Sensors (Basel) ; 22(21)2022 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-36365891

RESUMO

Intelligent manufacturing, defined as the integration of manufacturing with modern information technologies such as 5G, digitalization, networking, and intelligence, has grown in popularity as a means of boosting the productivity, intelligence, and flexibility of traditional manufacturing processes. The steel industry is a necessary support for modern life and economic development, and the Chinese steel industry's capacity has expanded to roughly half of global production. However, the Chinese steel industry is now confronted with high labor costs, massive carbon emissions, a low level of intelligence, low production efficiency, and unstable quality control. Therefore, China's steel industry has launched several large-scale intelligent manufacturing initiatives to improve production efficiency, product quality, manual labor intensity, and employee working conditions. Unfortunately, there is no comprehensive overview of intelligent manufacturing in China's steel industry. We began this research by summarizing the construction goals and overall framework for intelligent manufacturing of the steel industry in China. Following that, we offered a brief review of intelligent manufacturing for China's steel industry, as well as descriptions of two typical intelligent manufacturing models. Finally, some major technologies employed for intelligent production in China's steel industry were introduced. This research not only helps to comprehend the development model, essential technologies, and construction techniques of intelligent manufacturing in China's steel industry, but it also provides vital inspiration for the manufacturing industry's digital and intelligence updates and quality improvement.


Assuntos
Indústrias , Aço , Comércio , Controle de Qualidade , Inteligência , China
7.
Sensors (Basel) ; 22(21)2022 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-36365974

RESUMO

Aiming at the low efficiency of manual measurement of threads and the lack of practicability in machine vision measurement before, online size measurement of threads at the end of sucker rods based on machine vision was studied. A robotic arm is used to carry an optical device to achieve high-quality image acquisition of threads. Based on the prior knowledge of the thread profile angle, the directional edge detection operator is customized to achieve the accurate detection of the left and right edges of the thread. Noise filtering, sorting, and left and right edge-matching algorithms based on connected domains are developed to eliminate the interference effects of electrostatic dust and oil pollution in online measurement, and the dimension of thread profile angles, pitches, major diameters, and minor diameters can be precisely calculated. The experimental results show that the screw thread parameter measurement time is about 0.13 s; the maximum and minimum average errors of the thread angles are 0.011° and 0.632°, respectively; and the total average deviation is less than 0.08°. For the screw thread pitch, major diameter, minor diameter, and pitch diameter parameter measurement, the deviation of the measurement results between the proposed method and the universal tool microscope (UTM) method is less than 10 µm. It fully proves the effectiveness and accuracy of the method in this paper and, at the same time, shows that the method has good real-time performance and high application significance, which lays a good foundation for the subsequent online thread measurement.


Assuntos
Parafusos Ósseos , Software , Algoritmos
8.
J Neurol ; 2022 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-36385201

RESUMO

OBJECTIVE: To describe the disease progression of Duchenne muscular dystrophy (DMD) in the pelvic and thigh muscles over 1-year using multiple-parameter quantitative magnetic resonance imaging (qMRI), and to determine the most responsive muscle and predict subclinical disease progression in functionally stable patients. METHODS: Fifty-four DMD patients (mean age 8.9 ± 2.5, range 5-15 years) completed baseline and 1-year follow-up qMRI examinations/biomarkers [3-point Dixon/fat fraction (FF); T1 mapping/T1; T2 mapping/T2]. Meanwhile, clinical assessments [NorthStar ambulatory assessment (NSAA) score] and timed function tests were performed in DMD patients. Twenty-four healthy male controls (range 5-15 years) accomplished baseline qMRI examinations. Group differences were compared using the Wilcoxon test. The standardized response mean (SRM) was taken as the responsiveness to the disease progression index. RESULTS: FF, T1, and T2 in all DMD age subgroups changed significantly over 1-year (P < 0.05). Even in functionally stable patients (NSAA score increased, unchanged, or decreased by 1-point) over 1-year, significant increases in FF and T2 and decreases in T1 were observed in gluteus maximus (GMa), gluteus medius, vastus lateralis, and adductor magnus (P < 0.05). Overall, the SRM of FF, T1, and T2 was all the highest in GMa, which were 1.25, - 0.92, and 0.93, respectively. CONCLUSIONS: qMRI biomarkers are responsive to disease progression and can also detect subclinical disease progression in functionally stable DMD patients over 1-year. GMa is the most responsive to disease progression of all the muscles analyzed. TRIAL REGISTRATION: Chinese Clinical Trial Registry ( http://www.chictr.org.cn/index.aspx ) ChiCTR1800018340, 09/12/2018, prospectively registered.

9.
Front Endocrinol (Lausanne) ; 13: 990133, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36339425

RESUMO

Background and objectives: Diabetes mellitus is a serious metabolic disease that causes a serious economic burden worldwide. Gut flora is a major component of diabetes research, and the aim of this study was to understand the trends and major components of research related to diabetes and gut flora in the last 11 years. Methods: We searched the Web of Science Core Collection database for articles on diabetes and gut flora related research from 2011-2021 on July 2, 2022. The literature data were analyzed for country, institution, author, steward, journal, and highly cited literature using Citespace.5.8.R3 and Vosviewer1.6.17. Results: Finally 4834 articles that met the requirements were included. The overall trend of articles published in the last 11 years is increasing, and the trend of articles published after 2019 is increasing significantly. In total, 109 countries, 4820 institutions, and 23365 authors were involved in the field of research. The highest number of publications was 1262 articles from the United States, the institution with the most publications was the University of Copenhagen with 134 articles, and the author with the most publications was PATRICE D CANI with 52 articles. Conclusion: The number of studies related to diabetes and intestinal flora is increasing and more and more researchers are involved in this field. Intestinal flora provides a key research direction for the treatment of diabetes. In the future, gut flora will remain the focus of the diabetes field.


Assuntos
Diabetes Mellitus , Microbioma Gastrointestinal , Humanos , Bibliometria , Publicações , Diabetes Mellitus/epidemiologia , Bases de Dados Factuais
10.
Front Oncol ; 12: 991378, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36353556

RESUMO

Background: This retrospective study compared positron emission tomography (PET)/computed tomography (CT) and CT in the treatment of extracranial oligometastatic non-small-cell lung cancer (NSCLC) and explored the impact of thorax radiotherapy (TRT) on patient survival. Methods: We reviewed the medical records of Chinese patients with stage IV extracranial oligometastatic NSCLC who underwent PET/CT or CT at two centers. Propensity score matching (PSM) was used to control differences in patient characteristics between the maintenance chemotherapy alone and TRT plus maintenance chemotherapy groups. Results: We analyzed 192 eligible patients. The median survival time was better in patients who received PET/CT than in those who only received CT (n = 192, 16 months vs. 6 months, p<0.001). Subgroup analysis showed the median survival time was significantly longer in the TRT plus maintenance group than in the chemotherapy alone group in patients who underwent PET/CT examinations (n = 94, 25 months vs. 11 months, p<0.001). However, there was no statistical difference in survival between both groups in patients who underwent CT examinations (n = 98, 8 months vs. 5 months, p = 0.180). A multifactorial analysis revealed a more favorable prognosis in patients who underwent PET/CT evaluation (HR: 0.343, 95% CI: 0.250-0.471, p <0.001) and TRT (HR: 0.624, 95% CI: 0.464-0.840, p = 0.002), than in those who did not. PSM was consistent with these results. Conclusions: PET/CT-guided TRT is associated with improved clinical outcomes in patients with stage IV extracranial oligometastatic NSCLC.

11.
Artigo em Inglês | MEDLINE | ID: mdl-36394924

RESUMO

Developing dielectric capacitors with both a high power density and a high energy density for application in power electronics has been a long-standing challenge. Glass-ceramics offer the potential of retaining the high relative permittivity of ceramics and at the same time of exhibiting the high dielectric breakdown strength and fast charge/discharge rate of glasses, thus producing concurrently high power and energy densities in a single material. In this work, glass-ceramics are fabricated to achieve simultaneously high power and energy densities, high efficiency, and thermal stability by tuning the glass crystallization process via a suitable nucleating agent and a high oxygen partial pressure. Under the same practical charge-discharge test conditions, the as-prepared glass-ceramics combine the high energy density of ceramics and ultrafast discharge rate of glasses, producing the highest power density among glass- and ceramic-based dielectric materials. This work demonstrates the significant potential of achieving both high power and energy densities in glass-ceramics by optimizing the glass crystallization process.

12.
Chin J Integr Med ; 2022 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-36369611

RESUMO

OBJECTIVE: To explore the mechanisms of Buyang Huanwu Decoction (BYHWD) modulating the gut microbiome and trimethylamine oxide (TAMO) to exert cardioprotective effects. METHODS: Ligation of the left anterior descending coronary artery was performed in rats to induce heart failure (HF). Except for the sham-operation group (n=10), 36 operation-induced models were randomized into 3 groups using a random number table (n=12 in each group): the model group, the BYHWD group (15.02 g/kg BYHWD), and the positive group (4.99 g/kg metoprolol succinate). After 4-week treatment (once daily by gavage), echocardiography was applied to evaluate the cardiac function and the Tei index (the ratio of ventricular isovolumic contraction time (IVCT) and isovolumic diastolic time (IVRT) to ejection time (ET)) was calculated; hematoxylin-eosin (HE) staining was observed to characterize the pathology of the myocardium and small intestinal villi. D-lactic acid was detected by an enzyme-linked immunosorbent assay (ELISA). Expressions of occludin, claudin-1, and zonula occludens (ZO-1) were detected by Western blot. 16S ribosomal ribonucleic acid (16S rRNA) sequencing was used to explore the changes in the intestinal flora. TMAO was detected via liquid chromatography-tandem mass spectrometry (LC-MS/MS). RESULTS: In the echocardiography, the Tei index was considerably lower in the positive and BYHWD groups compared with the model group (P<0.05). Besides, BYHWD improved the pathology of myocardium and small intestine of HF rats and lowered the D-lactic acid content in the serum, when compared with the model group (P<0.05). BYHWD also improved the expression of occludin and claudin-1 (P<0.05); in the gut microbiota analysis, BYHWD slowed down modifications in the structure distribution of gut microbiota and regulated the diversity of intestinal flora in HF rats. The content of TMAO in the serum was significantly lowered by BYWHT compared with the model group (P<0.05). CONCLUSION: BYHWD may delay progression of HF by enhancing the intestinal barrier structure, and regulating intestinal flora and TAMO.

13.
Int J Mol Sci ; 23(21)2022 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-36362290

RESUMO

Potassium (K+) is essential for plant growth and stress responses. A deficiency in soil K+ contents can result in decreased wheat quality and productivity. Thus, clarifying the molecular mechanism underlying wheat responses to low-K+ (LK) stress is critical. In this study, a tandem mass tag (TMT)-based quantitative proteomic analysis was performed to investigate the differentially abundant proteins (DAPs) in roots of the LK-tolerant wheat cultivar "KN9204" at the seedling stage after exposure to LK stress. A total of 104 DAPs were identified in the LK-treated roots. The DAPs related to carbohydrate and energy metabolism, transport, stress responses and defense, and post-translational modifications under LK conditions were highlighted. We identified a high-affinity potassium transporter (TaHAK1-4A) that was significantly up-regulated after the LK treatment. Additionally, TaHAK1-4A was mainly expressed in roots, and the encoded protein was localized in the plasma membrane. The complementation assay in yeast suggested that TaHAK1-4A mediates K+ uptake under extreme LK conditions. The overexpression of TaHAK1-4A increased the fresh weight and root length of Arabidopsis under LK conditions and improved the growth of Arabidopsis athak5 mutant seedlings, which grow poorly under LK conditions. Moreover, silencing of TaHAK1-4A in wheat roots treated with LK stress decreased the root length, dry weight, K+ concentration, and K+ influx. Accordingly, TaHAK1-4A is important for the uptake of K+ by roots exposed to LK stress. Our results reveal the protein metabolic changes in wheat induced by LK stress. Furthermore, we identified a candidate gene potentially relevant for developing wheat lines with increased K+ use efficiency.


Assuntos
Arabidopsis , Deficiência de Potássio , Deficiência de Potássio/metabolismo , Arabidopsis/metabolismo , Triticum/genética , Triticum/metabolismo , Proteômica , Raízes de Plantas/metabolismo , Potássio/metabolismo , Plântula/genética , Plântula/metabolismo , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo
14.
Knowl Inf Syst ; : 1-27, 2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36348735

RESUMO

With more and more news articles appearing on the Internet, discovering causal relations between news articles is very important for people to understand the development of news. Extracting the causal relations between news articles is an inter-document relation extraction task. Existing works on relation extraction cannot solve it well because of the following two reasons: (1) most relation extraction models are intra-document models, which focus on relation extraction between entities. However, news articles are many times longer and more complex than entities, which makes the inter-document relation extraction task harder than intra-document. (2) Existing inter-document relation extraction models rely on similarity information between news articles, which could limit the performance of extraction methods. In this paper, we propose an inter-document model based on storytree information to extract causal relations between news articles. We adopt storytree information to integer linear programming (ILP) and design the storytree constraints for the ILP objective function. Experimental results show that all the constraints are effective and the proposed method outperforms widely used machine learning models and a state-of-the-art deep learning model, with F1 improved by more than 5% on three different datasets. Further analysis shows that five constraints in our model improve the results to varying degrees and the effects on the three datasets are different. The experiment about link features also suggests the positive influence of link information.

15.
Cells ; 11(21)2022 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-36359832

RESUMO

In terms of mortality and survival, pancreatic cancer is one of the worst malignancies. Known as a unique type of programmed cell death, cuprotosis contributes to tumor cell growth, angiogenesis, and metastasis. Cuprotosis programmed-cell-death-related lncRNAs (CRLs) have been linked to PAAD, although their functions in the tumor microenvironment and prognosis are not well understood. This study included data from the TCGA-PAAD cohort. Random sampling of PAAD data was conducted, splitting the data into two groups for use as a training set and test set (7:3). We searched for differentially expressed genes that were substantially linked to prognosis using univariate Cox and Lasso regression analysis. Through the use of multivariate Cox proportional risk regression, a risk-rating system for prognosis was developed. Correlations between the CRL signature and clinicopathological characteristics, tumor microenvironment, immunotherapy response, and chemotherapy sensitivity were further evaluated. Lastly, qRT-PCR was used to compare CRL expression in healthy tissues to that in tumors. Some CRLs are thought to have strong correlations with PAAD outcomes. These CRLs include AC005332.6, LINC02041, LINC00857, and AL117382.1. The CRL-based signature construction exhibited outstanding predictive performance and offers a fresh approach to evaluating pre-immune effectiveness, paving the way for future studies in precision immuno-oncology.


Assuntos
Apoptose , Cobre , Neoplasias Pancreáticas , RNA Longo não Codificante , Humanos , Apoptose/genética , Regulação Neoplásica da Expressão Gênica , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/patologia , RNA Longo não Codificante/genética , RNA Longo não Codificante/metabolismo , Microambiente Tumoral/genética , Cobre/metabolismo
16.
Front Immunol ; 13: 995895, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36389806

RESUMO

Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects multiple systems and organs. In severe cases, SS is life-threatening because it can lead to interstitial lung disease, renal insufficiency, and lymphoma. Histological examination of the labial minor salivary glands of patients with SS reveals focal lymphocyte aggregation of T and B cells. More studies have been conducted on the role of B cells in the pathogenesis of SS, whereas the role of T cells has only recently attracted the attention of researchers. This review focusses on the role of various populations of T cells in the pathogenesis of SS and the progress made in research to therapeutically targeting T cells for the treatment of patients with SS.


Assuntos
Aparelho Lacrimal , Síndrome de Sjogren , Humanos , Síndrome de Sjogren/etiologia , Síndrome de Sjogren/terapia , Síndrome de Sjogren/diagnóstico , Linfócitos T/patologia , Glândulas Salivares Menores/patologia , Aparelho Lacrimal/patologia , Autoanticorpos
17.
Eur J Radiol ; 157: 110601, 2022 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-36399870

RESUMO

Coronary calcification plays a major role as a key surrogate measure of plaque burden, providing powerful risk stratification and influencing preventive therapy. Depending on its location and density, microcalcifications may directly result in plaque rupture and adverse clinical events. Although macroscopic calcifications are frequently linked to advanced and stable plaques, the fact that a small number of thrombotic events are caused by plaques that possess a substantial amount of calcification should not be overlooked. Early and accurate assessment of calcium content in atherosclerotic plaques potentially enhances the identification of high-risk patients requiring preventive treatments. Non-invasive imaging allows for the visualization, detection, and quantification of calcific lesions, whereas intravascular imaging has the unique advantage of providing real-time and accurate information during calcium modification interventions. Simultaneously, emerging molecular imaging modalities aid in the investigation of calcification activity. This review summarizes advanced techniques for coronary artery calcification imaging, including their merits and limitations, in addition to their potential applications in both experimental and clinical settings.

18.
Front Immunol ; 13: 950921, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36389781

RESUMO

The preferred treatment for lung cancer is surgical resection, but a large number of patients are not suitable for surgical resection in clinic. CT-guided cryoablation and immunotherapy can play an important role in patients with advanced lung cancer who are ineligible for surgery. CT-guided cryoablation has been widely used in the clinical treatment of lung tumors due to its advantages of less trauma, fewer complications, significant efficacy and rapid recovery. Cryoablation can not only cause tumor necrosis and apoptosis, but also promote the release of tumor-derived autoantigens into the blood circulation, and stimulate the host immune system to produce a good anti-tumor immune effect against primary and metastatic tumors. Since the study of immune checkpoint inhibitors has proved that lung cancer can be an immunotherapeutic response disease, the relationship between cryoablation and immunotherapy of lung cancer has been paid more attention. Therefore, we reviewed the literature on cryoablation for lung cancer, as well as the research progress of cryoablation combined with immunotherapy.


Assuntos
Ablação por Cateter , Criocirurgia , Neoplasias Pulmonares , Humanos , Resultado do Tratamento , Imunoterapia
19.
Psychopharmacology (Berl) ; 239(12): 3953-3962, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36344824

RESUMO

OBJECTIVE: Lifelong premature ejaculation (PE) is regarded as one of the most common male sexual dysfunction. We aimed to detect whether insula-related brain functional networks are altered in lifelong PE patients and whether such alterations are "normalised" after selective serotonin reuptake inhibitors (SSRI) administration. METHODS: Twenty-three drug-naive lifelong PE patients and 30 healthy controls (HC) were recruited in current study. All subjects underwent resting-state functional magnetic resonance imaging (fMRI) scan at first. One hour after dapoxetine administration, all patients underwent fMRI scanning again. The degree centrality (DC), amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) analysis, and ROI-based functional connectivity (FC) analysis were applied to calculate the abnormalities in insula-related functions among three groups. RESULTS: Compared to HC group, PE patients at baseline showed significantly altered DC, ALFF, and ReHo value of the bilateral insula, which subsequently showed a "normalised" trend after dapoxetine administration. Additionally, compared to HC group, PE patients at baseline showed significantly decreased FC between insula and precentral gyrus, inferior frontal gyrus, middle/inferior temporal gyrus, and caudate, while patients after dapoxetine administration showed increased insula-related FC in anterior cingulate cortex and decreased FC in thalamus and middle/inferior temporal gyrus. The main effects of dapoxetine were located in precentral gyrus, inferior frontal gyrus, caudate, and limbic system. CONCLUSIONS: Our findings report altered brain mechanism of insula in lifelong PE patients and also indicate that dapoxetine can "normalise" the abnormal function of the insula to certain extent in lifelong PE patients.


Assuntos
Ejaculação Precoce , Humanos , Masculino , Ejaculação Precoce/diagnóstico por imagem , Ejaculação Precoce/tratamento farmacológico , Inibidores de Captação de Serotonina/farmacologia , Benzilaminas/farmacologia , Naftalenos , Imageamento por Ressonância Magnética/métodos , Encéfalo/diagnóstico por imagem
20.
BMC Cancer ; 22(1): 1182, 2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36384523

RESUMO

BACKGROUND: Gut microbiome has been linked to a regulatory role in cancer progression. However, whether broad-spectrum antibiotics (ATB) associated gut microbiome dysbiosis contributes to an impaired T cell immune function, and ultimately promotes lung cancer metastasis is not well known. METHODS: In this study, a retrospective analysis was performed in a cohort of 263 patients initially diagnosed with non-small cell lung cancer (NSCLC) patients, including the ATB group (patients with broad-spectrum antibiotics treatment) (n = 124), and non-ATB group (n = 139) as control. ATB patients were prescribed ATB for over 5 days within 30 days prior to the collection of blood and fecal specimens and followed surgical treatment or first-line therapy. T cell immune function and metastasis-free survival (MFS) were evaluated between the two groups. Gut microbiota was evaluated by 16S rDNA sequencing. The predictive value of T cell immunity for MFS was evaluated by ROC analysis and Cox regression analysis. RESULTS: Our results suggest that broad-spectrum antibiotics (ATB) impair T cell immune function in patients with either early-stage or advanced NSCLC, which likely contribute to the promotion of lung cancer metastasis. Results of the survival analysis show that metastasis-free survival (MFS) is significantly shorter in the ATB patients than that in the non-ATB patients with stage III NSCLC. The 16S rDNA sequencing shows that ATB administration contributes to a significant dysbiosis of the composition and diversity of gut microbiota. Moreover, ROC analysis results of CD4 (AUC 0.642, p = 0.011), CD8 (AUC was 0.729, p < 0.001), CD16 + 56 + (AUC 0.643, p = 0.003), and the combination of CD4, CD8 and CD16 + 56+ (AUC 0.810, p < 0.001), or Cox regression analysis results of CD4 (HR 0.206, p < 0.001), CD8 (HR 0.555, p = 0.009), which is likely regulated by ATB administration, have significantly predictive values for MFS. CONCLUSION: These results provide evidence of gut microbiome disturbance due to ATB administration is involved in the regulation of T cell immunity, and their predictive value for the tumor metastasis in lung cancer patients. Thus, gut microbiota may serve as a therapeutic target for lung cancer. Consequently, caution should be exercised before the long-term administration of broad-spectrum antibiotics in cancer patients.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Microbioma Gastrointestinal , Neoplasias Pulmonares , Humanos , Neoplasias Pulmonares/patologia , Carcinoma Pulmonar de Células não Pequenas/patologia , Microbioma Gastrointestinal/fisiologia , Estudos Retrospectivos , Disbiose/induzido quimicamente , Antibacterianos/efeitos adversos , Processos Neoplásicos , Linfócitos T/patologia , DNA Ribossômico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...