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1.
Sci Total Environ ; : 150881, 2021 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-34627919

RESUMO

Reducing the energy consumption and electrode cost for electrochemical recovery of phosphorus (P) from wastewater is crucial for the large-scale application. In this study, biochar electrodes were investigated as the low-cost cathode in a microbial electrolysis cell (MEC) and this P-enriched biochar electrode was directly retrieved as P fertilizer after wastewater treatment. The Fe2+ salt modified biochar significantly increased the electrochemical performance of MECs due to the improved electrical conductivity and cathodic activity. Compared to the pristine biochar cathode, the current density of the MEC increased from 16.8 ±â€¯0.2 A/m3 to 20.7 ±â€¯0.8 A/m3, and the P removal increased from 28.8% ±â€¯1% to 62.4% ±â€¯3.5%. The power consumption was 0.25 ±â€¯0.01 kWh/kg P which was more than one order of magnitude lower than the previous report. It was also demonstrated that the P enriched biochar amended soil improved the Pakchoi cultivation.

2.
Org Biomol Chem ; 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34622268

RESUMO

Tetracyclic norditerpene dilactones are an important class of terpenoids that have been isolated from both terrestrial and marine sources, typically from Podocarpus plants and from filamentous fungi. This class of molecules shares a common 6/6/6/5 tetracyclic ring skeleton, which possesses a densely oxygenated carbon framework and contiguous stereocenters. What's more challenging for synthetic chemists are the consecutive sp2-hybridized carbon centers, which exacerbates the strain/rigidity of the whole molecule. In addition, many of these molecules display promising biological activities, such as antitumor, insecticidal, anti-feedant, allelopathic, and antibiotic activities. The unique structures and interesting biological profiles of norditerpene dilactones have attracted considerable attention from synthetic chemists. Herein we summarize the synthetic efforts with respect to tetranorditerpene dilactones.

3.
Clin Oral Investig ; 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34622309

RESUMO

OBJECTIVES: To assess alveolar bone changes and treatment modality alterations after ridge preservation on maxillary molar extraction sockets with severe periodontitis, compared to natural healing. MATERIAL AND METHODS: Thirty-six maxillary infected-molar teeth either receiving ridge preservation (RG group) or undergoing natural healing (NT group) were investigated. Cone-beam computed tomography (CBCT) scanning was performed immediately after surgery (the baseline) and repeated 6 months later to measure the linear and volumetric changes of the sockets. RESULTS: Based on radiographic measurements, alveolar bone width decreased by 1.58 ± 4.61 mm in the NT group but increased by 3.74 ± 4.17 mm in the RG group (p < 0.05). Significant increases in ridge height at the center of both the NT (7.54 ± 4.54 mm) and RG (9.20 ± 3.26 mm) groups were observed. Mean sinus pneumatization was 0.19 ± 0.45 mm in the RG group and 0.59 ± 0.63 mm in the NT group (p < 0.05). The relative increase in total ridge volume was 8.0% and 35.5% in the NT and RG group, respectively (p < 0.05). Implant placement with additional sinus augmentation procedure was performed in 16.7% of the RG group cases, whereas 50% in the NT group cases. CONCLUSIONS: Ridge preservation in the maxillary molar extraction sockets with severe periodontitis can improve alveolar ridge dimensions and decrease the necessity of advanced regenerative procedures at implant placement compared to natural healing. CLINICAL RELEVANCE: Ridge preservation on maxillary molar extraction sockets with severe periodontitis maintained the vertical bone height more efficiently and resulted in less need for sinus augmentation procedures at 6 months compared to natural healing.

4.
J Phys Chem Lett ; : 10079-10085, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34624196

RESUMO

We used temperature-programmed infrared reflection absorption spectroscopy (TP-IRAS) to study the desorption behavior of CO on Pt(111) coadsorbed with four kinds of ionic liquids (ILs), namely 1-butyl-1-methyl-pyrrolidinium-bis(trifluoromethylsulfonyl)imide ([C4C1Pyr][NTf2]), 1-ethyl-3-methyl-imidazolium-bis(trifluoromethylsulfonyl)imide ([C2C1Im][NTf2]), 1-butyl-1-methyl-pyrrolidinium-trifluoro-methanesulfonate ([C4C1Pyr][OTf]), and 1-butyl-1-methyl-pyrrolidinium-hexafluorophosphate ([C4C1Pyr][PF6]). We found that CO desorbs earlier from a Pt(111) surface with coadsorbed ILs than without. In addition, the CO desorption temperature varies between different types of coadsorbed ILs, which follows the order: [C4C1Pyr][PF6] (365 K) > [C4C1Pyr][NTf2] (362 K) > [C2C1Im][NTf2] (352 K) > [C4C1Pyr][OTf] (348 K). We ascribe the difference in CO desorption temperature to the different interaction strength between ILs and the Pt(111) surface. A stronger IL-Pt(111) interaction leads to a lower CO desorption temperature. We suggest that TP-IRAS experiments of CO coadsorbed with ILs can be a useful method to aid the characterization of the interaction strength between ILs and metal surfaces such as Pt(111).

5.
Int J Mol Med ; 48(6)2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34608496

RESUMO

The main aim of the present study was to explore the role of long­chain non­coding RNA (lncRNA) growth arrest­specific transcript 5 (GAS5) in macrophage autophagy. Firstly, the expression of lncRNA GAS5 during cell starvation or following treatment with 3­methyladenine was determined using reverse transcription­quantitative PCR (RT­qPCR). Additionally, fluorescent in situ hybridization (FISH) assay was utilized to determine the localization of the expression of lncRNA GAS5 in RAW264.7 cells. In vitro cell models were established through the transfection of LV5­lncRNA GAS5 (LV5­GAS5) or LV3­shRNA­lnc GAS5 (sh­GAS5), in order to overexpress or knockdown lncRNA GAS5 expression in RAW264.7 cells. The potential target microRNAs (miRNAs/miRs) of lncRNA GAS5 were analyzed using bioinformatics. The formation of autophagic bodies was detected with the use of laser confocal and transmission electron microscopy. Dual­luciferase reporter assay was performed to determine the target specificities of miR­181c­5p or miR­1192 to lncRNA GAS5 and autophagy­related gene (ATG) or ATG12. The mRNA levels of miR181c­5p, miR­1192, as well as ATG5 and ATG12 were detected using RT­qPCR. The protein levels of microtubule­associated proteins 1A/1B light chain 3B (LC3), p62, ATG5 and ATG12 were measured using western blot analysis. It was revealed that lncRNA GAS5 expression in RAW264.7 macrophages increased significantly during starvation­induced autophagy, and that lncRNA GAS5 overexpression was able to markedly promote the formation of autophagic bodies. Bioinformatics analysis demonstrated that miR­181c­5p and miR­1192 were potential targets of lncRNA GAS5, which was further confirmed by RT­qPCR, western blot analysis and the dual­luciferase reporter assay. Finally, it was confirmed that lncRNA GAS5 promoted autophagy by sponging miR­181c­5p and miR­1192, and upregulating the expression levels of the key autophagic regulators, ATG5 and ATG12. On the whole, the present study demonstrates that total, lncRNA GAS5 promotes macrophage autophagy by targeting the miR­181c­5p/ATG5 and miR­1192/ATG12 axes.

6.
IEEE Trans Med Imaging ; PP2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34606453

RESUMO

Medical images from multicentres often suffer from the domain shift problem, which makes the deep learning models trained on one domain usually fail to generalize well to another. One of the potential solutions for the problem is the generative adversarial network (GAN), which has the capacity to translate images between different domains. Nevertheless, the existing GAN-based approaches are prone to fail at preserving image-objects in image-to-image (I2I) translation, which reduces their practicality on domain adaptation tasks. In this regard, a novel GAN (namely IB-GAN) is proposed to preserve image-objects during cross-domain I2I adaptation. Specifically, we integrate the information bottleneck constraint into the typical cycle-consistency-based GAN to discard the superfluous information (e.g., domain information) and maintain the consistency of disentangled content features for image-object preservation. The proposed IB-GAN is evaluated on three tasks-polyp segmentation using colonoscopic images, the segmentation of optic disc and cup in fundus images and the whole heart segmentation using multi-modal volumes. We show that the proposed IB-GAN can generate realistic translated images and remarkably boost the generalization of widely used segmentation networks (e.g., U-Net).

7.
Int Immunopharmacol ; 101(Pt A): 108202, 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34619495

RESUMO

BACKGROUND: Mycobacterium tuberculosis (M. tuberculosis), which parasitizes host macrophages and lead to cellular immunologic responses, such as autophagy and apoptosis. Several studies had indicated that autophagy played important roles in alleviating intracellular survival of M. tuberculosis by accelerating the maturation of phagosome. Previously, we found miR-142-3p was significantly down-regulated in the macrophages after infection with M. tuberculosis. However, the role of miR-142-3p in the regulation of autophagy and M. tuberculosis survival is elusive. METHODS: Bioinformatics analysis was used to obtain target genes of miR-142-3p; the binding sites of ATG16L1 and ATG4c were further confirmed with dual luciferase reporter assay; RAW264.7 cells were infected with H37Ra and the expression of miR-142-3p was measured by qRT-PCR; the autophagic marker protein was detected by western blot as well as immunofluorescence microscopy and transmission electron microscopes analysis. RESULTS: Overexpression of miR-142-3p significantly inhibited H37Ra-induced activation of autophagy, blocked the maturation of phagosome in macrophages and promoted M. tuberculosis survival in macrophages. Furthermore, miR-142-3p negatively-regulated expression of ATG16L1 and ATG4c by directly targeting its 3'-UTR, and meaningfully abated the level of autophagy. CONCLUSION: These findings suggested that miR-142-3p inhibited M. tuberculosis-induced activation of autophagy and promoted H37Ra survival in RAW264.7 cells by targeting ATG16L1 and ATG4c.

8.
Cell Death Dis ; 12(10): 936, 2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34642320

RESUMO

Although many studies have explored the mechanism of epilepsy, it remains unclear and deserves further investigation. Vezatin has been reported to be a synaptic regulatory protein involved in regulating neuronal synaptic transmission (NST). However, the role of vezatin in epilepsy remains unknown. Therefore, the aims of this study are to investigate the underlying roles of vezatin in epilepsy. In this study, vezatin expression was increased in hippocampal tissues from pilocarpine (PILO)-induced epileptic mice and a Mg2+-free medium-induced in vitro seizure-like model. Vezatin knockdown suppressed seizure activity in PILO-induced epileptic mice. Mechanistically, vezatin knockdown suppressed AMPAR-mediated synaptic events in epileptic mice and downregulated the surface expression of the AMPAR GluA1 subunit (GluA1). Interestingly, vezatin knockdown decreased the phosphorylation of GluA1 at serine 845 and reduced protein kinase A (PKA) phosphorylation; when PKA phosphorylation was suppressed by H-89 (a selective inhibitor of PKA phosphorylation) in vitro, the effects of vezatin knockdown on reducing the phosphorylation of GluA1 at serine 845 and the surface expression of GluA1 were blocked. Finally, we investigated the pattern of vezatin in brain tissues from patients with temporal lobe epilepsy (TLE), and we found that vezatin expression was also increased in patients with TLE. In summary, the vezatin expression pattern is abnormal in individuals with epilepsy, and vezatin regulates seizure activity by affecting AMPAR-mediated NST and the surface expression of GluA1, which is involved in PKA-mediated phosphorylation of GluA1 at serine 845, indicating that vezatin-mediated regulation of epileptic seizures represents a novel target for epilepsy.

9.
Ageing Res Rev ; 72: 101481, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34606985

RESUMO

Iron is an essential element for proper functioning of cells within mammalian organ systems; in particular, iron homeostasis is critical for joint health. Excess iron can induce oxidative stress damage, associated with the pathogenesis of iron-storage and ageing-related diseases. Therefore, iron levels in body tissues and cells must be tightly regulated. In the past decades, excess iron content within joints has been found in some patients with joint diseases including hemophilic arthropathy, hemochromatosis arthropathy, and osteoarthritis (OA). Currently, increased evidence has shown that iron accumulation is closely associated with multiple pathological changes of these arthropathies. This review summarizes system-level and intracellular regulation of iron homeostasis, and emphasizes the role of iron in synovial alterations, cartilage degeneration, and subchondral bone of several arthropathies. Of note, we discuss the potential link between iron homeostasis and OA pathogenesis. Finally, we discuss the therapeutic potential of maintaining iron homeostasis in these arthropathies.

10.
Bioresour Technol ; : 126049, 2021 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-34592456

RESUMO

The alteration of antibiotic resistance genes (ARGs) during sludge composting has been less studied in a full-scale plant, causing the miss of practical implications for understanding/managing ARGs. Therefore, this study tracked the changes of ARGs and microbial communities in a full-scale plant engaged in excess sludge composting and then explored the key factors regulating ARGs through a series of analyses. After composting, the absolute and relative abundance of ARGs decreased by 91.90% and 66.57%, respectively. Additionally, PLS-PM analysis showed that MGEs, composting physicochemical properties were the most vital factors directly influencing ARGs. Finally, network analysis indicated that Proteobacteria, Bacteroidetes, Firmicutes, and Actinobacteria were the main hosts of ARGs. Based on these findings, it can be known that full-scale composting could reduce ARGs risk to an extent.

11.
Artigo em Inglês | MEDLINE | ID: mdl-34574677

RESUMO

The COVID-19 epidemic has had a significant impact on society. In particular, it has had a strong impact on college students, including international students. Through an online questionnaire survey, it is found that the psychological distress experienced by international students is the result of a combination of the external environment (including the lockdown measures, social distancing, and social support) and internal factors such as values and behavior. The analysis shows that the new teaching mode and the corresponding changes in learning behavior are significantly associated with the psychological distress brought about by the COVID-19 epidemic. In addition, the influence of international students' values also plays a significant role in their psychological distress. Collective values are conducive to the alleviation of psychological distress, while individual values have the opposite effect. At the same time, the study also reveals that if there is sufficient social support, isolation (due to lockdown or social distancing early or later on) is not necessarily directly related to psychological distress. However, only formal social support can effectively alleviate psychological distress, while informal social support does not play a similar role. These conclusions have certain policy significance for the prevention of and response to epidemics in other countries.


Assuntos
COVID-19 , Angústia Psicológica , China/epidemiologia , Controle de Doenças Transmissíveis , Humanos , Pandemias , SARS-CoV-2 , Estudantes
12.
Medicine (Baltimore) ; 100(35): e27165, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34477173

RESUMO

BACKGROUND: The mechanism of cryptogenic stroke (CS) in patients with atrial septal abnormalities remains unclear, and the increased incidence of atrial vulnerability may be one of the reasons. We performed this meta-analysis to clarify the association between atrial septal abnormalities and atrial vulnerability, and to provide evidence-based basis for the prevention and mechanism of CS. METHODS: We systematically searched for studies on the association between atrial septal abnormalities and atrial vulnerability, and pooled available data on types of atrial septal abnormalities, types of atrial vulnerability, and methods of atrial vulnerability detection. The primary endpoints were the occurrence of atrial arrhythmias or P wave abnormalities. Random-effects models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Twelve case-control studies were eligible. Compared with the control group, patients with atrial septal abnormalities had a higher risk of atrial vulnerability (OR: 1.93; 95% CI: 1.13-3.30, P = .02). Data based on stroke patients showed that the group with atrial septal abnormalities had a higher risk of atrial vulnerability than the control group (OR: 2.00; 95% CI: 1.13-3.53, P = .02). However, there was no significant difference in the incidence of atrial vulnerability between the 2 groups of nonstroke patients. Subgroup analysis showed that although atrial septal abnormality increased the risk of atrial vulnerability in the subgroup of atrial septal aneurysm (OR: 1.68; 95% CI: 0.47-5.95, P = .42), the subgroup of atrial fibrillation (AF)/atrial fluster (OR: 1.81; 95% CI: 0.94-3.46, P = .07) and the subgroup of subcutaneous recording system (OR: 1.33; 95% CI: 0.68-2.61, P = .41), the difference was not statistically significant. CONCLUSIONS: Atrial septal abnormalities can increase the risk of atrial vulnerability, and atrial arrhythmia caused by atrial septal abnormalities may be one of the mechanisms of CS.


Assuntos
Arritmias Cardíacas/etiologia , Comunicação Interatrial/complicações , AVC Isquêmico/etiologia , Estudos de Casos e Controles , Humanos
13.
Neoplasia ; 23(11): 1089-1100, 2021 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-34587566

RESUMO

Brain metastases frequently occur in lung cancer and dramatically limit prognosis of affected patients. The influence of tumor-associated macrophages and microglia (TAM/M) and their receptor CX3CR1 on different steps of brain metastasis formation from lung cancer is poorly characterized. We established a syngeneic orthotopic cerebral metastasis model in mice by combining a chronic cranial window with repetitive intravital 2-photon laser scanning microscopy. This allowed in vivo tracking of fluorescence-expressing tumor cells and TAM/M on a single-cell level over weeks. Intracarotid injection of red tdTomato-fluorescent Lewis lung carcinoma cell was performed in transgenic mice either proficient or deficient for CX3CR1. After intracarotid cell injection, intravascular tumor cells extravasated into the brain parenchyma and formed micro- and mature macrometastases. We observed potential phagocytosis of extravasated tumor cells by TAM/M. However, during later steps of metastasis formation, these anti-tumor effects diminished and were paralleled by TAM/M accumulation and activation. Although CX3CR1 deficiency resulted in a lower number of extravasated tumor cells, progression of these extravasated cells into micro metastases was more efficient. Overall, this resulted in a comparable number of mature macrometastases in CX3CR1-deficient and -proficient mice. Our findings indicate that unspecific inhibition of CX3CR1 might not be a suitable therapeutic option to prevent dissemination of lung cancer cells to the brain. Given the close interaction between TAM/M and tumor cells during metastasis formation, other therapeutic approaches targeting TAM/M function may warrant further evaluation. The herein established orthotopic mouse model may be a useful tool to evaluate such concepts in vivo.

14.
J Neural Eng ; 18(5)2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-34534980

RESUMO

Objective.Unconsciousness is a key feature related to general anesthesia (GA) but is difficult to be evaluated accurately by anesthesiologists clinically.Approach.To tracking the loss of consciousness (LOC) and recovery of consciousness (ROC) under GA, in this study, by investigating functional connectivity of the scalp electroencephalogram, we explore any potential difference in brain networks among anesthesia induction, anesthesia recovery, and the resting state.Main results.The results of this study demonstrated significant differences among the three periods, concerning the corresponding brain networks. In detail, the suppressed default mode network, as well as the prolonged characteristic path length and decreased clustering coefficient, during LOC was found in the alpha band, compared to the Resting and the ROC state. When to further identify the Resting and LOC states, the fused network topologies and properties achieved the highest accuracy of 95%, along with a sensitivity of 93.33% and a specificity of 96.67%.Significance.The findings of this study not only deepen our understanding of propofol-induced unconsciousness but also provide quantitative measurements subserving better anesthesia management.

15.
BJOG ; 2021 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-34536320

RESUMO

OBJECTIVE: To estimate the incidence of urinary incontinence (UI), including its subtype: stress UI (SUI), urgency UI (UUI), and mixed UI (MUI), and to examine risk factors for de novo SUI and UUI in Chinese women. DESIGN: Nationwide longitudinal study. SETTING: Six geographic regions of China PARTICIPANTS: Women aged ≥20 years old were included using a multistage, stratified, cluster sampling method. METHODS: This study was conducted between May 2014 and March 2016, with follow-up in 2018. Data on demographics, medical history, lifestyle, physiological and anthropometric information were collected. MAIN OUTCOME MEASUREMENTS: incidence, rate ratio (RR) RESULTS: Analyses included 24,985 women ( mean age, 41.9 years old).The follow-up response rate was 55.5%, median follow-up time was 3.7 years. The standardized incidence of UI, SUI, UUI and MUI were 21.2, 13.1, 3.0, and 5.1/1000 person-years, respectively. Risk factors for de novo SUI included delivery pattern (vaginal spontaneous delivery (RR 2.12, 95% confidence interval 1.62-2.78), instrumental delivery (3.30, 1.99-5.45)), high body -mass index (BMI) (overweight (1.52, 1.33-1.74), obesity (1.67, 1.32-2.11)), cigarette smoking (1.54, 1.12-2.12), chronic cough (1.44, 1.17-1.76), diabetes (1.33, 1.10-1.60), and older age (50-59 years (1.49, 1.16-1.90), 60-69 years (1.61, 1.22-2.13)).The risk factors significantly associated with de novo UUI were age (RR increased from 1.21 (0.74-1.99) at 30-39 years to 6.3 (3.85-10.30) at >70 years) and diabetes (1.48, 1.05-2.09). CONCLUSIONS: The incidence of female UI is 21.2/1000 person-years in China. Delivery (vaginal spontaneous delivery, instrumental delivery), high BMI, cigarette smoking, chronic cough, diabetes, and older age were risk factors.

16.
DNA Cell Biol ; 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34491823

RESUMO

Microsatellite instability (MSI) is emerging as a promising subtype related to immunotherapy in gastric cancer (GC). However, the underlying mechanism between MSI and microsatellite stability (MSS) remains unclear. In this study, we conducted a weighted gene co-expression network analysis and found that the expression of heterogeneous nuclear ribonucleoprotein L (HNRNPL) was significantly increased in MSI GC compared with MSS GC. This finding was further validated in public GC cohorts and commercialized human GC tissue microarray. The significant negative correlation with the expression of mismatch repair protein mutL homolog 1 (MLH1) may be one of the potential mechanisms for the upregulation of HNRNPL expression in MSI GC (R = -0.689, p = 8.59e-11). In addition, HNRNPL expression was markedly upregulated in GC tissues compared with adjacent normal tissues. High HNRNPL expression also predicted a poor prognosis in GC patients. Finally, gene set enrichment analysis revealed that high HNRNPL MSI GC samples were highly positive associated with the biological functions of inflammation and cell proliferation, such as interferon gamma response, MYC targets, E2F targets, and G2/M checkpoints. In conclusion, HNRNPL could be a new MSI-associated prognostic biomarker in GC and could be a new target for the MSI GC treatment.

18.
Anal Chim Acta ; 1179: 338820, 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34535251

RESUMO

The number of CD8+ T lymphocytes (CD8 cells) in peripheral blood can directly reflect the immune status of the body and is widely used for auxiliary diagnosis and prognostic evaluation of diseases. There is an urgent need to develop a simple CD8 cell-counting platform to meet clinical needs. Our group designed a paper-based cell-counting method based on a blocking competition strategy. In addition, we developed a time-resolved fluorescence-blocking competitive lateral flow immunoassay (TRF-BCLFIA) for point-of-care CD8 cell counting that functions by measuring europium nanoparticle (EuNP)-labeled CD8 antibody probes that are not captured by CD8 cells, and we indirectly calculated the concentration of CD8 cells in samples. Within 30 min, four operation steps can provide an accurate CD8 cell count for a 75-µL whole-blood sample, and this approach can be implemented on a handheld device. The TRF-BCLFIA reliably quantified CD8 cells in whole-blood samples, in which the assay exhibited a linear correlation (R2 = 0.989) readout for CD8 cell concentrations ranging from 137 to 821 cells/µL. To validate this approach, our newly developed CD8 cell-counting tool was used to assess 33 tumor patient blood samples. The results showed a high consistency with a flow cytometry-based absolute count. This analysis approach is a promising alternative for the costly standard flow cytometry-based tools for CD8 cell counting in tumor patients in community clinics, small hospitals, and low medical resource regions. This technology would deliver simple diagnostics to patients anywhere in the world, regardless of geography or socioeconomic status.


Assuntos
Európio , Nanopartículas Metálicas , Linfócitos T CD8-Positivos , Citometria de Fluxo , Fluorimunoensaio , Humanos
20.
J Affect Disord ; 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34565588

RESUMO

OBJECTIVES: Male lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) is common and may increase the risk of depressive symptoms. This study aimed to investigate the associated factors of LUTS/BPH and its association with depressive symptoms in middle-aged and older Chinese men. METHODS: This study used data from the 2015 China Health and Retirement Longitudinal Study (CHARLS). A total number of 8,586 men aged ≥45 years were included in this study. Participants answered positively to whether they have ever been diagnosed with a prostate illness (excluding prostatic cancer) were defined as LUTS/BPH individuals. Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10). Multivariate logistic analyses were applied to explore the associated factors of LUTS/BPH, association between LUTS/BPH and depressive symptoms, and risk factors of depressive symptoms according to LUTS/BPH status. RESULTS: The weighted overall prevalence of LUTS/BPH was 13.1% in Chinese men aged ≥45 years. The prevalence of depressive symptoms was 29.1% in LUTS/BPH individuals and 22.9% in non-LUTS/BPH individuals. Depressive symptoms and LUTS/BPH shared some same risk factors, which were education, living regions, annual household consumption, sleep duration and multimorbidity. The results from logistic models showed that education, sleep duration and multimorbidity were significantly and independently associated with depression of LUTS/BPH individuals (P<0.001). CONCLUSIONS: Prevalence of depressive symptoms in LUTS/BPH population was higher than in non-LUTS/BPH population. Education, sleep duration and multimorbidity were associated with the onset of depressive symptoms in LUTS/BPH individuals (P<0.001).

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