Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.365
Filtrar
1.
J Environ Sci (China) ; 124: 823-834, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36182186

RESUMO

Electrocoagulation (EC) has been widely used to treat the heavy metal wastewater in industry. A novel process of sinusoidal alternating current electrocoagulation (SACC) is adopted to remove Ni2+ in wastewater in this study. The morphology of precipitates and the distribution of the main functional iron configurations were investigated. Ferron timed complex spectroscopy can identify the monomeric iron configurations [Fe(a)], oligomeric iron configurations [Fe(b)] and polymeric iron configurations [Fe(c)]. The optimal operating conditions of SACC process were determined through single-factor experiments. The maximum Ni2+ removal efficiency [Re(Ni2+)] was achieved under the conditions of pH0=7, current density (j) = 7 A/m2, electrolysis time (t) = 25 min, c0(Ni2+) = 100 mg/L. At pH=7, the proportion of Fe(b) and Fe(c) in the system was 50.4 at.% and 23.1 at.%, respectively. In the SACC process, Fe(b) and Fe(c) are the main iron configurations in solution, while Fe(c) are the vast majority of the iron configurations in the direct current electrocoagulation (DCC) process. Re(Ni2+) is 99.56% for SACC and 98.75% for DCC under the same optimum conditions, respectively. The precipitates produced by SACC have a high proportion of Fe(b) configurations with spherical α-FeOOH and γ-FeOOH structures which contain abundant hydroxyl groups. Moreover, it is demonstrated that Fe(b) has better adsorption capacity than Fe(c) through adsorption experiments of methyl orange (MO) dye. Fe(a) configurations in the homogeneous solution had no effect on the removal of nickel.


Assuntos
Metais Pesados , Poluentes Químicos da Água , Purificação da Água , Eletrocoagulação , Eletrodos , Concentração de Íons de Hidrogênio , Ferro/química , Níquel , Águas Residuárias , Poluentes Químicos da Água/análise , Purificação da Água/métodos
2.
Clin Rehabil ; 37(1): 119-131, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36039504

RESUMO

OBJECTIVE: Rehabilitation may mitigate the high mortality rates and health declines post-fracture for adults with cerebral palsy, but this is understudied. The objectives were to characterize the post-fracture rehabilitation pathways and identify their association with 1-year survival among adults with cerebral palsy. METHODS: A retrospective cohort study of adults with cerebral palsy with a fragility fracture with continuous health plan enrollment ≥1-year prior to and ≥1 day after their fracture date was performed using a random 20% Medicare fee-for-service dataset. Participants were categorized as a home discharge or inpatient rehabilitation admission post-fracture. For the home discharge cohort, weekly exposure to outpatient physical/occupational therapy (PT/OT) was examined up to 6-month post-fracture. Cox regression examined the association between time-varying PT/OTuse within 6-month post-fracture and mortality from 30 days to 1-year post-fracture before and after adjusting for confounders (e.g. medical complexity). RESULTS: Of 3598 adults with cerebral palsy with an incident fragility fracture, 74% were discharged home without inpatient rehabilitation; they were younger, but more medically complex compared to the 26% admitted to inpatient rehabilitation. Among the home discharge cohort (n = 2662), 43.1% initiated PT/OTwithin 6-month post-fracture, and cumulative PT/OTexposure post-fracture was associated with improved survival; for example, per 3 weeks of PT/OTexposure, the adjusted mortality rate was 40% lower (95% confidence interval (CI) = 0.41-0.89). CONCLUSIONS: Most adults with cerebral palsy with a fragility fracture were discharged home rather than to inpatient rehabilitation, and only 43.1% of that group initiated outpatient PT/OTwithin 6 months post-fracture. Receiving outpatient PT/OTwas associated with improved 1-year survival.


Assuntos
Paralisia Cerebral , Fraturas Ósseas , Idoso , Adulto , Humanos , Estados Unidos , Medicare , Estudos Retrospectivos , Paralisia Cerebral/diagnóstico , Planos de Pagamento por Serviço Prestado , Alta do Paciente
3.
J Environ Sci (China) ; 125: 101-111, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36375897

RESUMO

The short-term impacts of urban air pollution on the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) remain obscure. In this study, we included 3487 urban adults from the Wuhan-Zhuhai cohort. Individual inhalation exposure to air pollutants was estimated by combining participants' daily breath volume and ambient concentrations of six air pollutants (including fine particulate matter (PM2.5), inhalable particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO) and ozone (O3)). The cumulative impacts were assessed by applying lag structures of up to 7 days before the survey date. Associations of air pollutants with PLR and NLR were assessed using a linear mixed model and Bayesian kernel machine regression (BKMR) model. We found that PLR was negatively related to PM2.5 (lag02-lag06), PM10 (lag02-lag07), NO2 (lag02-lag07), and SO2 (lag03-lag05) and NLR was negatively related to PM10 (lag05 and lag07). In the BKMR model, a negative joint association between the six-air-pollutant mixture and PLR and NLR was observed, whereas PM10 and NO2 appeared to be more important than the other pollutants in the mixture. The negative impact of air pollutants was stronger in males, participants with lower body mass index (< 24 kg/m2), those cooking meals at home, drinkers, and non-exercisers. In conclusion, short-term exposure to air pollutants is significantly related to PLR and NLR in peripheral blood. PLR and NLR may provide new insight into the molecular mechanism underlying the adverse health impact of air pollutants.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Ozônio , Humanos , Adulto , Masculino , Dióxido de Nitrogênio/análise , Neutrófilos/química , Teorema de Bayes , Poluentes Atmosféricos/análise , Material Particulado/análise , Ozônio/análise , Dióxido de Enxofre/análise , China , Linfócitos , Exposição Ambiental/análise
4.
Sci Total Environ ; 857(Pt 3): 159679, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36283521

RESUMO

Waste activated sludge and food waste are two typical important domestic low-value organic solid wastes (LOSW). LOSW contains significant organic matter and water content resulting in the transboundary transfer of liquid-solid-gas and other multi-mediums, such that the complexity of microplastics (MPs) migration should be of greater concern. This article provides a review of the literature focusing on the separation and extraction methods of MPs from LOSW. The occurrence and source of MPs are discussed, and the output and impact of MPs on LOSW heat and biological treatments are summarized. The fate and co-effects of MPs and other pollutants in landfills and soils are reviewed. This review highlights the migration and transformation of MPs in domestic source LOSW, and future perspectives focused on the development of a unified extraction and analysis protocol. The objective of this review is to promote the technological development of decontamination of MPs in LOSW by sufficient understanding of the fate of MPs, their interaction with coexisting pollutants and the development of targeted preventive research strategies.


Assuntos
Poluentes Ambientais , Eliminação de Resíduos , Poluentes Químicos da Água , Microplásticos , Plásticos , Resíduos Sólidos/análise , Alimentos , Poluentes Ambientais/análise , Poluentes Químicos da Água/análise , Águas Residuárias/análise
5.
Bioact Mater ; 20: 651-662, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35846839

RESUMO

The development of wearable artificial livers was restricted to device miniaturization and bleeding risk with water-soluble anticoagulants. Herein, a double-deck column filled with solid anticoagulant microspheres and Kevlar porous microspheres (KPMs, bilirubin adsorbents) was connected with the principle machine of wearable artificial liver (approximately 9 kg) to treat hyperbilirubinemia beagles for the first time. With the initial normal dose of heparin, the double-deck column could afford 3 h hemoperfusion in whole blood without thrombus formation. The removal efficiency of the double-deck column for total bilirubin (TBIL) was 31.4%. Interestingly, the excessive amounts of hepatocyte metabolites were also decreased by approximately 25%. The "anticoagulant + column" realized safe and effective whole blood hemoperfusion without the plasma separation system and heparin pump; however, the proposed principle machine of wearable artificial liver and "anticoagulant + column" cannot completely replace the bio-liver now. The intelligence of the device and the versatility of the adsorbent need to be improved; moreover, advanced experimental techniques need to be developed to validate the survival rates in animals. Overall, this study is a meaningful trial for the development of wearable artificial livers in the future.

6.
Cardiovasc Ther ; 2022: 5443880, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36349299

RESUMO

The aim of the study was to investigate the factors influencing contrast-induced acute kidney injury (CI-AKI) after percutaneous intervention (PCI) in patients with acute coronary syndrome (ACS) with diabetes mellitus (DM). A total of 1073 patients with ACS combined with DM who underwent PCI at the Affiliated Hospital of Xuzhou Medical University were included in this study. We divided the patients into the CI-AKI and non-CI-AKI groups according to whether CI-AKI occurred or not. The patients were then randomly assigned to the training and validation sets at a proportion of 7 : 3. Based on the results of the LASSO regression and multivariate analyses, we determined that the subtypes of ACS, age, multivessel coronary artery disease, hyperuricemia, low-density lipoprotein cholesterol, triglyceride-glucose index, and estimated glomerular filtration rate were independent predictors on CI-AKI after PCI in patients with ACS combined with DM. Using the above indicators to develop the nomogram, the AUC-ROC of the training and validation sets were calculated to be 0.811 (95% confidence interval (CI): 0.766-0.844) and 0.773 (95% CI: 0.712-0.829), respectively, indicating high prediction efficiency. After verification by the Bootstrap internal verification, we found that the calibration curves showed good agreement between the nomogram predicted and observed values. And the DCA results showed that the nomogram had a high clinical application. In conclusion, we constructed and validated the nomogram to predict CI-AKI risk after PCI in patients with ACS and DM. The model can provide a scientific reference for predicting the occurrence of CI-AKI and improving the prognosis of patients.


Assuntos
Síndrome Coronariana Aguda , Injúria Renal Aguda , Diabetes Mellitus , Intervenção Coronária Percutânea , Humanos , Síndrome Coronariana Aguda/diagnóstico por imagem , Síndrome Coronariana Aguda/terapia , Intervenção Coronária Percutânea/efeitos adversos , Nomogramas , Triglicerídeos , Glucose , Meios de Contraste/efeitos adversos , Fatores de Risco , Injúria Renal Aguda/induzido quimicamente , Injúria Renal Aguda/diagnóstico , Injúria Renal Aguda/terapia , Diabetes Mellitus/diagnóstico
7.
J Immunol ; 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36427008

RESUMO

Abnormally high follicle-stimulating hormone (FSH) has been reported to associate with cardiovascular diseases in prostate cancer patients with specific androgen deprivation therapy and in menopausal women. All of the cardiovascular diseases were involved in atherosclerosis. However, the pathogenic mechanism of FSH-associated atherosclerosis remains uncertain. Apolipoprotein E-deficient mice were chosen to develop atherosclerosis, of which the plaques were analyzed with administration of short- and long-term FSH imitating androgen deprivation therapy-induced and menopausal FSH elevation. The study showed that short- and long-term exposure of FSH significantly accelerated atherosclerosis progression in apolipoprotein E-deficient mice, manifested as strikingly increased plaques in the aorta and its roots, increased macrophage content, reduced fibrin, and an enlarged necrotic core, suggesting a decrease in plaque stability. Furthermore, expression profiles from the Gene Expression Omnibus GSE21545 dataset revealed that macrophage inflammation was tightly associated with FSH-induced atherosclerotic progression. The human monocyte cell line THP-1 was induced by PMA and worked as a macrophage model to detect inflammatory factors and cellular functions. FSH remarkably promoted the expression of IL-1ß in macrophages and strikingly increased the chemotactic migratory capacity of macrophages toward MCP-1, but the promigratory capacity of FSH was attenuated in foam cells. Overall, we revealed that FSH significantly promoted the inflammatory response and migration of macrophages, thereby provoking atherosclerosis development.

8.
J Biomater Sci Polym Ed ; : 1-36, 2022 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-36373498

RESUMO

Tympanic membrane perforation is a common condition in clinical otolaryngology. Although some eardrum patients can self-heal, a long period of non-healing perforation leads to persistent otitis media, conductive deafness, and poor quality of life. Tympanic membrane repair with autologous materials requires a second incision, and the sampling site may get infected. It is challenging to repair tympanic membranes while maintaining high functionality, safety, affordability, and aesthetics. 3D bioprinting can be used to fabricate tissue patches with materials, factors, and cells in a design manner. This paper reviews 3D printing technology that is being used widely in recent years to construct eardrum stents and the utilized applied materials for tympanic membrane repair. The paper begins with an introduction of the physiological structure of the tympanic membrane, briefly reviews the current clinical method thereafter, highlights the recent 3D printing-related strategies in tympanic membrane repair, describes the materials and cells that might play an important role in 3D printing, and finally provides a perspective of this field.

9.
J Exp Bot ; 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36416766

RESUMO

N 6-methyladenosine (m 6A) RNA methylation has been shown to play a crucial role in plant development and floral transition. Two recent studies have identified FIONA1 as an m 6A methyltransferase that regulates the floral transition via influencing the stability of CONSTANS (CO), SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1), and FLOWERING LOCUS C (FLC) in Arabidopsis. In this study, we confirmed that FIONA1 is an m 6A methyltransferase that installs m 6A marks in a small group of mRNAs. Furthermore, in addition to its role in influencing the stability of CO, SOC1, and FLC, we show that FIONA1-mediated m 6A methylation influences the splicing of FLC, a key floral repressor, and the stability of SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE 3 (SPL3) and SEPALLATA3 (SEP3), floral activators, which plays a vital role in the floral transition in Arabidopsis. Our study confirms FIONA1 as an m 6A methyltransferase and suggests a close molecular link between FIONA1-mediated m 6A methylation and the splicing of FLC and the destabilization of SPL3 and SEP3 in flowering time control.

10.
J Immunol ; 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36368721

RESUMO

Abnormally high follicle-stimulating hormone (FSH) has been reported to associate with cardiovascular diseases in prostate cancer patients with specific androgen deprivation therapy and in menopausal women. All of the cardiovascular diseases were involved in atherosclerosis. However, the pathogenic mechanism of FSH-associated atherosclerosis remains uncertain. Apolipoprotein E-deficient mice were chosen to develop atherosclerosis, of which the plaques were analyzed with administration of short- and long-term FSH imitating androgen deprivation therapy-induced and menopausal FSH elevation. The study showed that short- and long-term exposure of FSH significantly accelerated atherosclerosis progression in apolipoprotein E-deficient mice, manifested as strikingly increased plaques in the aorta and its roots, increased macrophage content, reduced fibrin, and an enlarged necrotic core, suggesting a decrease in plaque stability. Furthermore, expression profiles from the Gene Expression Omnibus GSE21545 dataset revealed that macrophage inflammation was tightly associated with FSH-induced atherosclerotic progression. The human monocyte cell line THP-1 was induced by PMA and worked as a macrophage model to detect inflammatory factors and cellular functions. FSH remarkably promoted the expression of IL-1ß in macrophages and strikingly increased the chemotactic migratory capacity of macrophages toward MCP-1, but the promigratory capacity of FSH was attenuated in foam cells. Overall, we revealed that FSH significantly promoted the inflammatory response and migration of macrophages, thereby provoking atherosclerosis development.

11.
J Wound Care ; 31(11): 930-940, 2022 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-36367804

RESUMO

OBJECTIVE: To evaluate the safety and effectiveness of polylactic acid/gelatin nanofibre membranes (PGNMs) in treating hard-to-heal lower extremity venous ulcer wounds. METHOD: In this prospective study, patients with venous leg ulcers (VLUs) were treated with PGNMs or standard of care. Wounds were assessed once a week until the wound was fully healed. RESULTS: The treatment group was comprised of 10 patients with VLUs, aged between 47-64 years, with an average age of 56.58±6.19 years. The wounds were located in the lower leg and/or ankle. Average wound area was 8.91±13.57cm2 (range: 1.5-52.5cm2). Average wound healing time was 18.75±16.36 days. Of the patients, nine (90%) rated their pain as lighter when removing the dressing, with an average pain value of 2.0±1.0 points. There was less secondary trauma to the wound surface, and less bleeding. At six months after the wound healing, the scar evaluation (using the Vancouver Scar Scale) result was 3.75±1.96 points. CONCLUSION: In this study, the PGNMs were safe and effective in treating hard-to-heal lower extremity VLUs.


Assuntos
Nanofibras , Úlcera Varicosa , Humanos , Pessoa de Meia-Idade , Úlcera Varicosa/terapia , Gelatina/uso terapêutico , Estudos Prospectivos , Cicatriz , Cicatrização , Extremidade Inferior , Dor
12.
Cells ; 11(21)2022 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-36359901

RESUMO

Renal fibrosis is a common pathological feature of various kidney diseases, leading to irreversible renal failure and end-stage renal disease. However, there are still no effective treatments to reverse renal fibrosis. This study aimed to explore the potential mechanism of a targeted drug for fibrosis. Here, unilateral ureteral obstruction (UUO)-treated mice and a TGF-ß1-treated human renal tubular epithelial cell line (HK-2 cells) were used as models of renal fibrosis. Based on the changes of mRNA in UUO kidneys detected by transcriptome sequencing, MK-2206, an Akt inhibitor, was predicted as a potential drug to alleviate renal fibrosis through bioinformatics. We dissolved UUO mice with MK-2206 by gastric gavage and cultured TGF-ß-induced HK-2 cells with MK-2206. Histopathological examinations were performed after MK-2206 intervention, and the degree of renal fibrosis, as well as the expression of Akt/mTOR pathway-related proteins, were evaluated by immunohistochemical staining, immunofluorescence staining, and Western blot. The results showed that MK-2206 significantly improved the pathological structure of the kidney. Furthermore, MK-2206 intervention effectively inhibited UUO- and TGF-ß1-induced epithelial-mesenchymal transition, fibroblast activation, and extracellular matrix deposition. Mechanistically, MK-2206 treatment attenuated the activation of the Akt/mTOR signaling pathway. Taken together, our study revealed for the first time that MK-2206 is a promising drug for the improvement of renal fibrosis.


Assuntos
Nefropatias , Obstrução Ureteral , Camundongos , Humanos , Animais , Fator de Crescimento Transformador beta1/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Fibrose , Nefropatias/tratamento farmacológico , Nefropatias/metabolismo , Transdução de Sinais , Obstrução Ureteral/tratamento farmacológico , Serina-Treonina Quinases TOR/metabolismo
13.
Huan Jing Ke Xue ; 43(11): 5009-5017, 2022 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-36437073

RESUMO

The simultaneous observation and analysis of atmospheric particles on a regional scale is an important approach to developing control strategies for air pollution. To study the spatial distribution characteristics of particulate matter and water-soluble inorganic ions in the Ili Valley Urban agglomeration, PM2.5 and PM10 samples were synchronously collected from July 19 to July 29, 2021 in Yining City and the surrounding three counties, and then nine types of water-soluble inorganic ions (WSIIs) were analyzed. The spatial distribution characteristics, existence form of WSIIs, and influencing factors were discussed in depth. The results showed that the average ρ(PM2.5) and ρ(PM10) in the Ili River Valley urban agglomeration in summer were 23 µg·m-3 and 59 µg·m-3, respectively. The emission of local industrial and mobile sources in Yining City was higher than that of the surrounding three counties, resulting in the highest ρ(PM2.5) in the region (25 µg·m-3). Due to the influence of dust sources and topography, the ρ(PM10) in Yining county was the highest in the region (63 µg·m-3). Huocheng county is located upwind of the region, and these favorable diffusion conditions resulted in the lowest ρ(PM2.5) and ρ(PM10) (20 µg·m-3 and 49 µg·m-3, respectively). The concentrations of WSIIs in PM2.5 and PM10 ranged from 28.2%-29.9% and 16.0%-20.2%, respectively. The four main ions (SO42-, NO3-, NH4+, and Ca2+) accounted for approximately 90% of WSIIs mass concentrations. The concentration order of the four main ions in PM2.5 was SO42->Ca2+>NH4+>NO3- and SO42->Ca2+>NO3->NH4+ in PM10. The results of correlation analysis showed that the similar SO42- concentrations in the four cities were mainly caused by regional transport. Ca2+ was the highest-concentration ion in PM10 of Yining City and Qapqal Xibe Autonomous county, and the proportion of Ca2+ was significantly higher than that in most cities in China, which reflected that the cities in the core area of the Ili Valley were greatly affected by the dust sources. The ratios of n(NO3-)/n(SO42-) in PM2.5 and PM10 were 0.78 and 0.76, respectively, indicating that the influence of stationary sources was greater than that of mobile sources. The ratio of n(NO3-)/n(SO42-) in Yining City>Huocheng county>Yining county>Qapqal Xibe Autonomous county, which was consistent with the motor vehicle populations of the four cities, reflecting that Yining City was affected by motor vehicle sources more than the surrounding three counties. The secondary components mainly existed in the form of (NH4)2SO4, NH4HSO4, and NH4NO3. There was excess ammonia after the reaction between NH4+ and SO42- in each city. NH4NO3 mainly existed in Yining City, which was mainly related to high NO2 in Yining City. The NOR of the four cities were 0.03-0.10 and 0.03-0.16 in PM2.5 and PM10, respectively, and the secondary transformation of NO3- was weak due to the influence of high temperatures in summer. The SOR were 0.21-0.41 and 0.23-0.44, respectively. The SOR of Qapqal Xibe Autonomous county was the highest due to the relatively high humidity, whereas the SOR of Huocheng county was higher than that of the three sites in Yining City due to the influence of regional transportation. The formation mechanisms showed that SO42- in Qapqal Xibe Autonomous county and Yining City were mainly produced by the heterogeneous reaction, and in Yining county it was mainly formed via the homogeneous reaction. However, the formation mechanism in Huocheng county was complex and was affected by both homogeneous and heterogeneous reactions.


Assuntos
Poluentes Atmosféricos , Rios , Poluentes Atmosféricos/análise , Água/análise , Monitoramento Ambiental/métodos , Material Particulado/análise , Íons/análise , Poeira/análise
14.
Molecules ; 27(22)2022 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-36431777

RESUMO

Three undescribed phenylpropanoid derivatives, including two new bibenzyl constituents (1-2), one new stilbene constituent (3), together with five known compounds stilbostemin F (4), dihydropinosylvin (5), 2-(4-hydroxyphenyl)ethyl benzoate (6), 1-(4-hydroxybenzoyl)ethanone (7), and 4-hydroxy-3-prenylbenzoic acid (8), were isolated from the tuber of Asparagus cochinchinensis. The structures of 1-8 were elucidated according to UV, IR, HRMS, 1D and 2D-NMR methods together with the published literature. All of the isolated compounds were assessed for anti-inflammatory activity by acting on lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells in vitro. The results showed that compounds 2 and 5 were found to inhibit the production of nitric oxide (NO) with the IC50 value of 21.7 and 35.8 µM, respectively. In addition, further studies found that compound 2 demonstrated concentration-dependent suppression of the protein expression of iNOS and exerted anti-inflammatory activity via the NF-κB signalling pathway. The present data suggest that phenylpropanoid derivatives from the tuber of A. cochinchinensis might be used as a potential source of natural anti-inflammatory agents.


Assuntos
Anti-Inflamatórios , Asparagus , Animais , Camundongos , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/química , Células RAW 264.7 , Tubérculos , Lipopolissacarídeos
15.
Environ Pollut ; 316(Pt 2): 120631, 2022 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-36370971

RESUMO

Sulfidation can enhance the hydrophobicity of nano-zero valent iron (nZVI) and improve its long-term degradation performance in reduction technology. However, whether sulfidation can enhance its long-term performance in sulfate radical-based advanced oxidation processes hasn't been systematically studied. Herein sulfide-modified nZVI (S-nZVI) was prepared by different sulfidation methods and S/Fe ratios. The behavior of S-nZVI on the peroxymonosulfatec (PMS) activation to degrade 2-chlorobiphenyl for continuous 5 rounds was investigated. The results showed that sulfidation couldn't always promote the long-term degradation performance. S-nZVI prepared by one-step sulfidation method with high S/Fe ratio (S-nZVIonestep-7%, S-nZVIonestep-14%) exhibited inferior degradation performance than unmodified nZVI (52.2%). This was because that the electron donor Fe0 was consumed rapidly and the crystalline lepidocrocite accumulated on the surface, thus inhibited PMS activation. In contrast, S-nZVI prepared by post-sulfidation method with high S/Fe ratio (S-nZVIpost-7%, S-nZVIpost-14%) exhibited more Fe0 residual, less FeOx accumulation, and more catalytic Fe2+ regeneration. Consequently, S-nZVIpost exhibited superior degradation capacity (69.3%). Moreover, the radical quenching experiments revealed that the primary free radicals involved in the degradation were transformed from SO4•- to •OH with prolongation of the degradation. Additionally, Fe (IV) contributed to the degradation through non-radical mechanism, especially in the S-nZVIpost-7%/PMS system.

16.
Int J Biol Macromol ; 2022 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-36395946

RESUMO

Vascular transplantation has become an ideal substitute for heart and peripheral vascular bypass therapy and tissue-engineered vascular grafts (TEVGs) present an attractive potential solution for vascular surgery. However, small diameter (Ф < 6 mm) vascular do not have ideal TEVGs for clinical use. Platelet-rich plasma (PRP), a key source of bioactive molecules, has been confirmed to promote tissue repair and regeneration. In this study, we prepared PRP-loaded TEVGs (PRP-TEVGs) by electrospinning, investigated the characterization of TEVGs, and verified the effect of PRP-TEVGs in vivo and in vitro experiments. The results suggested that PRP-TEVGs had good biocompatibility, released growth factors stably, promoted cell proliferation and migration significantly, up-regulated the expression of endothelial NO synthase (eNOS) in functional vascular endothelial cells (VECs), and maintained the stability of the endothelial structure. In vivo experiments suggest that PRP can promote rapid endothelialization and reconstruction of TEVGs. Overall, this finding indicated that PRP could promote the rapid vascular endothelialization of small-diameter TEVGs by improving contractile vascular smooth muscle cells (VSMCs) regeneration, and maintaining the integrity and functionality of VECs.

17.
Water Res ; 227: 119321, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36368086

RESUMO

Due to the limitations of the conventional water sample pretreatment methods, some of the colloidal uranium (U) has long been misidentified as "dissolved" phase. In this work, the U species in river water in the Ili Basin was classified into submicron-colloidal (0.1-1 µm), nano-colloidal (0.1 µm-3 kDa) and dissolved phases (< 3 kDa) by using high-speed centrifugation and ultrafiltration. The U concentration in the river water was 5.39-8.75 µg/L, which was dominated by nano-colloidal phase (55-70%). The nano-colloidal particles were mainly composed of particulate organic matter (POM) and had a very high adsorption capacity for U (accounting for 70 ± 23% of colloidal U). Sediment disturbance, low temperature, and high inorganic carbon greatly improved the release of nano-colloidal U, but high levels of Ca2+ inhibited it. The simulated river experiments indicated that the flow regime determined the release of nano-colloidal U, and large amounts of nano-colloidal U might be released during spring floods in the Ili basin. Moreover, global warming increases river flow and inorganic carbon content, which may greatly promote the release and migration of nano-colloidal U.


Assuntos
Rios , Urânio , Urânio/análise , Coloides/análise , Carbono/análise , Água/análise
19.
BMC Oral Health ; 22(1): 511, 2022 11 17.
Artigo em Inglês | MEDLINE | ID: mdl-36397049

RESUMO

BACKGROUND: Changes in alveolar bone dimension after tooth extraction may affect placement of the subsequent implant, resulting in ridge deficiency that can adversely impact long-term implant stability or aesthetics. Alveolar ridge preservation (ARP) was effective in reducing the amount of ridge resorption following tooth extraction. There is sparse evidence regarding the benefit of ARP at periodontally compromised molar extraction sockets. This study will be a randomized trial to assess the soft tissue contour, radiographical, and histological changes of ARP at molar extraction sites in order to compare severe periodontitis cases with natural healing results and determine the most beneficial and least traumatic clinical treatment for such patients. METHODS: This research is designed as a two-group parallel randomized controlled trial. The total number of tooth extraction sites will be 70 after calculation with power analysis. Teeth will be randomly assigned to two groups with the test group conducting ridge preservation and the control group healing naturally. Periodontal examination, cone beam-computed tomography (CBCT) data, and stereolithographic (STL) files obtained by intraoral scanning will be collected through the follow-up period, and bone biopsy samples would be obtained during implant surgery. The primary outcomes are the vertical and horizontal change of alveolar ridge measured on CBCT images, soft tissue contour changes evaluated by superimposing the digital impressions, alterations of mucosa thickness (as measured by superimposing the CBCT data and STL files), histological features of implant sites and periodontal parameter changes. The secondary outcomes are patient-reported post-operative reaction and conditions of simultaneous bone graft or sinus lifting procedures during implantation. DISCUSSION: This study will provide information about hard and soft tissue dimension changes and histomorphology evaluation following ARP and natural healing in periodontally compromised molar sites, which may contribute to complement the missing information of ARP at periodontally compromised molar extraction sockets. TRIAL REGISTRATION: Chinese Clinical Trial Register (ChiCTR) ChiCTR2200056335. Registered on February 4, 2022, Version 1.0.


Assuntos
Perda do Osso Alveolar , Aumento do Rebordo Alveolar , Periodontite , Extração Dentária , Humanos , Perda do Osso Alveolar/diagnóstico por imagem , Perda do Osso Alveolar/prevenção & controle , Perda do Osso Alveolar/patologia , Aumento do Rebordo Alveolar/métodos , Dente Molar/cirurgia , Periodontite/cirurgia , Periodontite/patologia , Alvéolo Dental/diagnóstico por imagem , Alvéolo Dental/cirurgia
20.
Rev Sci Instrum ; 93(10): 103544, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-36319358

RESUMO

A repetitive plasma source for simulation of mitigated edge localized mode transient heat load is developed. The repetitive plasma source consists of a repetitive pulsed power supply and a pulsed plasma accelerator. The pulsed plasma accelerator is composed of a coaxial cathode, an anode, and an insulator. The inner electrode is the cathode with a diameter of 5 mm, and the outer electrode is the anode with a diameter of 15 mm. An angular magnetic field is generated by the discharge current and acts with the radial current to generate Lorentz force, which drives the plasma ejecting to the outlet. The repetitive pulsed power supply can be divided into three parts, the primary charge circuit, the resonant charge circuit, and the discharge circuit. The time interval between resonant charge and discharge is 4 ms. The repetitive discharge components include ten modules running in parallel. There are four working modes for discharge components, depending on the number of simultaneously discharged modules. For Mode A, the maximum repetitive frequency is 50 Hz, and the transient heat load is 0.06 MJ/m2 when the discharge current is 10.5 kA. For Mode D, the maximum repetitive frequency is 5 Hz, and the transient heat load is 0.45 MJ/m2 when the discharge current is 66 kA. This is of great significance for the study of the interaction between plasma and plasma-facing materials in tokamak.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...