Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 637
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Cancer Med ; 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31793749

RESUMO

BACKGROUND: Models for estimation of survival rates of patients with intracranial grade II/III ependymoma (EPN) are scarce. Considering the heterogeneity in prognostic factors between pediatric and adult patients, we aimed to develop age-specific nomograms for predicting 3-, 5-, and 8-year survival for these patients. METHODS: A total of 1390 cases (667 children; 723 adults) of intracranial grade II/III EPNs diagnosed between 1988 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database for our study. Univariable and multivariable Cox analyses were employed to identify independent prognostic predictors. Age-specific nomograms were developed based on the results of multivariate Cox analyses. We also evaluated the performance of these predictive models by concordance index, calibration curves, time-dependent receiver operating characteristic curves, and decision curve analyses. RESULTS: Considerable heterogeneity in prognostic factors was highlighted between pediatric and adult patients. Age, sex, tumor grade, surgery treatment and radiotherapy were identified as significant predictors of overall survival for children, and age, tumor grade, tumor size, surgery treatment, and marital status for adult. Based on these factors, age-specific nomogram models were established and internally validated. These models exhibited favorable discrimination and calibration characteristics. Nomogram-based risk classification systems were also constructed to facilitate risk stratification in EPNs for optimization of clinical management. CONCLUSIONS: We developed the first nomograms and corresponding risk classification systems for predicting survival in patients with intracranial grade II/III EPN. These easily used tools can assist oncologists in making accurate survival evaluation.

2.
BMC Bioinformatics ; 20(Suppl 16): 590, 2019 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-31787087

RESUMO

BACKGROUND: The number of biomedical research articles have increased exponentially with the advancement of biomedicine in recent years. These articles have thus brought a great difficulty in obtaining the needed information of researchers. Information retrieval technologies seek to tackle the problem. However, information needs cannot be completely satisfied by directly introducing the existing information retrieval techniques. Therefore, biomedical information retrieval not only focuses on the relevance of search results, but also aims to promote the completeness of the results, which is referred as the diversity-oriented retrieval. RESULTS: We address the diversity-oriented biomedical retrieval task using a supervised term ranking model. The model is learned through a supervised query expansion process for term refinement. Based on the model, the most relevant and diversified terms are selected to enrich the original query. The expanded query is then fed into a second retrieval to improve the relevance and diversity of search results. To this end, we propose three diversity-oriented optimization strategies in our model, including the diversified term labeling strategy, the biomedical resource-based term features and a diversity-oriented group sampling learning method. Experimental results on TREC Genomics collections demonstrate the effectiveness of the proposed model in improving the relevance and the diversity of search results. CONCLUSIONS: The proposed three strategies jointly contribute to the improvement of biomedical retrieval performance. Our model yields more relevant and diversified results than the state-of-the-art baseline models. Moreover, our method provides a general framework for improving biomedical retrieval performance, and can be used as the basis for future work.

3.
Future Oncol ; 2019 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-31799885

RESUMO

Aim: To elucidate the clinicopathological significance and prognostic value of SLC17A9 expression in gastric carcinoma (GC). Methods: SLC17A9 mRNA level and its relationship with TP53 mutation was analyzed. SLC17A9 protein expression was examined by immunohistochemistry in 161 patients. Results: SLC17A9 mRNA and protein expression were higher in GC tissues than in adjacent normal tissues (p < 0.01). SLC17A9 mRNA expression was higher in GC tissues having mutated TP53 than in tissues with wild-type TP53 (p < 0.001). High SLC17A9 expression was also significantly associated with poor overall survival and recurrence-free survival and was also found to be an independent prognostic factor for long-term survival in GC patients.Conclusion: Our results show that SLC17A9 may serve as a potential prognostic biomarker in GC patients.

4.
Toxicol Appl Pharmacol ; 384: 114789, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31669811

RESUMO

Previous studies showed that dopamine (DA) significantly reduces the frequency of cancer stem-like cells (CSC) and enhances the efficacy of sunitinib (SUN) in the treatment of breast cancer and non-small cell lung cancer (NSCLC). To overcome the shortcomings of DA in clinical practice, the purpose of this study was to investigate the efficacy as well as the underlying mechanism of an orally available, N-arylpiperazine-containing compound C2, in the treatment of pancreatic cancer when used alone or in combination with SUN. Our results showed that C2 and SUN exerted synergistic effects on inhibiting the growth of SW1990 and PANC-1 pancreatic cancer cells. C2 significantly inhibited colony formation and migration of both cells. SW1990 xenograft and patient-derived xenograft (PDX) models were utilized for pharmacodynamic investigation in vivo. C2 alone showed little inhibition effect on tumor growth but increased the anti-tumor efficacy of SUN in both xenografts. Moreover, C2 down-regulated CSC markers (CD133 and ALDH) of both cancer cells and up-regulated the expression of dopamine receptor D1 (D1DR) in tumor. Besides, the SW1990 tumor growth was dose-dependently inhibited when the cells were pretreated with C2 before implantation. C2 increased intratumoral cAMP level, and the combination with D1DR specific antagonist SCH23390 reversed the above-mentioned effects of C2 both in vitro and in vivo, indicating the activation of D1DR may be involved in the underlying mechanism of C2 action. In summary, C2 could reduce the CSC frequency and enhance the anti-cancer effect of SUN in the treatment of pancreatic cancer, demonstrating its potential in cancer therapy.

5.
Mar Drugs ; 17(12)2019 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-31779201

RESUMO

Sesterterpene MHO7 derived from mangrove fungus is a novel estrogen receptor degrader for the treatment of breast cancer. To explore its safety and pharmacokinetics in vivo, Log P/D values, stability in simulated gastric/intestinal (SGF/SIF), toxicity, and pharmacokinetics studies were carried mainly by liquid chromatography technique coupled with tandem mass spectrometry (LC-MS/MS) method in mice, and the effect of MHO7 on mice gut microbiota at different time points was revealed by 16S rRNA sequencing. Log P/D values ranged 0.93-2.48, and the compound in SGF and SIF is stable under the concentration of 5 mM·L-1. The maximum tolerance dose (MTD) of oral administration in mice was 2400 mg·kg-1. The main pharmacokinetics parameters were as following: Cmax of 1.38 µg·mL-1, Tmax of 8 h, a half-life (t1/2) of 6.97 h, an apparent volume of mean residual time (MRT) of 8.76 h, and an area under the curve (AUC) of 10.50 h·µg·mL-1. MHO7 displayed a wide tissue distribution in mice, with most of the compound in liver (3.01 ± 1.53 µg·g-1) at 1 h, then in fat (5.20 ± 3.47 µg·g-1) at 4 h, and followed by reproductive organs with the concentrations of 23.90 ± 11.33 µg·g-1,13.69 ± 10.29 µg·g-1, 1.46 ± 1.23 µg·g-1, and 0.36 ± 0.46 µg·g-1 at 8, 12, 20 and 30 h, respectively. The most influenced genera of gut microbiome belonged to phylum Firmicutes (21 of 28), among which 18 genera originated from the order Clostridiales, class Clostridia, and families of Ruminococcaceae (11 of 18) and Lachnospiraceae (4 of 18). These results provide that MHO7 is suitable for oral administration in the treatment of breast cancer with the target organs of reproductive organs and regulation on Ruminococcaceae and Lachnospiraceae.

6.
J Coll Physicians Surg Pak ; 29(12): S135-S137, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31779768

RESUMO

Ankylosing spondylitis (AS) with an Andersson lesion may cause kyphosis. As the disease progresses, kyphosis gradually worsens. When conservative treatment does not improve the symptoms, surgery is often needed to correct the deformity. The optimal surgical approach for ankylosing spondylitis with kyphosis remains controversial. Here, we introduce our surgical procedure of pseudoarticular debridgement and osteotomy of the apical vertebrae of the Cobb angle. We found that both the kyphosis and associated symptoms improved significantly after 13 months of follow-up.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31780116

RESUMO

Controllable fabrication of advanced electrode materials is critical for the development of lithium ion batteries (LIBs). Herein, for the first time, we report novel hierarchical porous chromium niobium oxide (Cr0.5Nb24.5O62) microspheres prepared by a facile one-step solvothermal method. The as-prepared Cr0.5Nb24.5O62 microspheres present 3D hierarchical porous structure consisting of cross-linked nanoparticles, high electronic conductivity and large specific surface area. Accordingly, the Cr0.5Nb24.5O62 microspheres show noticeable lithium ion storage performance with superior high-rate capability (199 mAh g-1 at 20C) and good cycling stability with a capacity retention of 95% over 1000 cycles, much better than the bulk Cr0.5Nb24.5O62 and TiNb24O62 counterparts. Our work demonstrates a new high-rate electrode material for high-power energy storage.

8.
Stem Cells ; 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31721388

RESUMO

Adult hair follicles undergo repeated cycling of regression (catagen), resting (telogen), and growth (anagen), which is maintained by hair follicle stem cells (HFSCs). The mechanism underlying hair growth initiation and HFSC maintenance is not fully understood. Here, by epithelial deletion of Hes1, a major Notch downstream transcriptional repressor, we found that hair growth is retarded, but the hair cycle progresses normally. Hes1 is specifically upregulated in the lower bulge/HG during anagen initiation. Accordingly, loss of Hes1 results in delayed activation of the secondary hair germ (HG) and shortened anagen phase. This developmental delay causes reduced hair shaft length but not identity changes in follicular lineages. Remarkably, Hes1 ablation results in impaired hair regeneration upon repetitive depilation. Microarray gene profiling on HFSCs indicates that Hes1 modulates Shh responsiveness in anagen initiation. Using primary keratinocyte cultures, we demonstrated that Hes1 deletion negatively influences ciliogenesis and Smoothened ciliary accumulation upon Shh treatment. Furthermore, transient application of Smoothened agonist during repetitive depilation can rescue anagen initiation and HFSC self-renewal in Hes1-deficient hair follicles. We reveal a critical function of Hes1 in potentiating Shh signaling in anagen initiation, which allows sufficient signaling strength to expand the HG and replenish HFSCs to maintain the hair cycle homeostasis. Stem Cells 2019.

9.
Nanoscale ; 11(45): 21934-21942, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31701979

RESUMO

The grand challenge inhibiting the use of electrocatalysts is the degradation of active species which results in poor durability and long-term performances. Studying the origin of active metal particle stabilization mechanisms by using supports and the immobilization-induced changes of active particles is of significant importance. This study describes the preparation of Pd nanoparticles supported by carbon hybrid NPG-CN, revealing that the mass and specific activities (1987 A g-1 Pd and 28.7 A m-2) of this catalyst for formic acid oxidation significantly exceed those of commercial Pd/C, and excellent stability and enhanced CO-poisoning tolerance properties are obtained. The origin of this behavior is probed by surface analytical techniques and identical-location transmission electron microscopy (IL-TEM), and the enhanced activity of Pd/NPG-CN is ascribed to the electronic effect of the substrate, the high content of surface metallic Pd0, and the reduced extent of active Pd leaching and physical ripening during the FOA process compared with commercial Pd/C. In addition, theoretical calculations demonstrate that NPG-CN can efficiently trap Pd atoms, which accumulate and form Pd clusters at trapping (nucleation) sites.

10.
Biol Pharm Bull ; 2019 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-31761827

RESUMO

This study focused on the differential metabolomic effects between water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata in rats. The extracts were subsequently administered for 28 days. Serum biochemical indicators were tested, hematoxylin-eosin staining and and immunohistochemistry staining were used to detect histopathological changes in the livers. Ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used to detect the changes in endogenous metabolites. Finally, we performed detailed analysis of the changes in metabolic pathways. Hematoxylin-eosin staining and immunohistochemistry staining results indicated that the water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata had mild liver injury effect. Fifty-two differential endogenous biomarkers were confirmed as potential biomarkers between Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata groups. In the positive ion mode, the biomarkers included 31 PCs, six lysoPCs, and ceramide. In the negative ion mode, 12 biomarkers were confirmed, including glycodeoxycholic acid, chenodeoxycholic acid, and deoxycholic acid and etc. In HILIC mode, nine biomarkers were confirmed, including niacinamide, L-palmitoylcarnitine, and butyrylcarnitine and etc. Using MetaboAnalyst 4.0, six related metabolic pathways, including taurine and hypotaurine metabolism, sphingolipid metabolism, glycerophospholipid metabolism, nicotinate and nicotinamide metabolism, arginine and proline metabolism, and tryptophan metabolism and primary bile synthesis, were confirmed as the most differential pathways between the Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata groups.

11.
Org Biomol Chem ; 2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31763665

RESUMO

A practical and efficient synthetic route to construct a variety of 3-amidated quinoxalin-2(1H)-ones was developed via transition-metal free direct oxidative amidation of quinoxalin-2(1H)-ones with amidates using Selectfluor reagent as a mild oxidant. This protocol features mild reaction conditions, operational simplicity, broad substrate scope, and good to excellent yields.

12.
Mol Cell ; 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31757757

RESUMO

Visualizing the location and dynamics of RNAs in live cells is key to understanding their function. Here, we identify two endonuclease-deficient, single-component programmable RNA-guided and RNA-targeting Cas13 RNases (dCas13s) that allow robust real-time imaging and tracking of RNAs in live cells, even when using single 20- to 27-nt-long guide RNAs. Compared to the aptamer-based MS2-MCP strategy, an optimized dCas13 system is user friendly, does not require genetic manipulation, and achieves comparable RNA-labeling efficiency. We demonstrate that the dCas13 system is capable of labeling NEAT1, SatIII, MUC4, and GCN4 RNAs and allows the study of paraspeckle-associated NEAT1 dynamics. Applying orthogonal dCas13 proteins or combining dCas13 and MS2-MCP allows dual-color imaging of RNAs in single cells. Further combination of dCas13 and dCas9 systems allows simultaneous visualization of genomic DNA and RNA transcripts in living cells.

13.
J Phys Condens Matter ; 32(9): 095402, 2019 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-31689692

RESUMO

The changes of methane hydrate lattice with the decrease of cage occupancy were calculated by first-principles methods. The calculation results show that the decrease of the cages occupancy in sII and sH hydrate does not lead to large deformation in the lattice. Even if all the methane molecules are removed so that the hydrates have become new types of ice, the sII and sH lattices remain stable. The same conclusion is also true when the occupancy of the small cages in sI hydrate is reduced. However, the sI hydrate lattice will deform and almost collapse as the large cage occupancy decreases. These calculation results suggest that sI hydrate cannot exist with empty cages. Since the van der Waals-Platteeuw theory is based on the assumption that the stability of host lattice is independent of the occupancy of guest molecule, it would be applicable to sII and sH lattices, but not to sI hydrates. We propose a modification to the van der Waals-Platteeuw hypothesis so that the theory seems more reasonable.

14.
Proc Natl Acad Sci U S A ; 116(42): 21274-21284, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31575745

RESUMO

Plasmodesmata (PD) are plant-specific membrane-lined channels that create cytoplasmic and membrane continuities between adjacent cells, thereby facilitating cell-cell communication and virus movement. Plant cells have evolved diverse mechanisms to regulate PD plasticity in response to numerous environmental stimuli. In particular, during defense against plant pathogens, the defense hormone, salicylic acid (SA), plays a crucial role in the regulation of PD permeability in a callose-dependent manner. Here, we uncover a mechanism by which plants restrict the spreading of virus and PD cargoes using SA signaling by increasing lipid order and closure of PD. We showed that exogenous SA application triggered the compartmentalization of lipid raft nanodomains through a modulation of the lipid raft-regulatory protein, Remorin (REM). Genetic studies, superresolution imaging, and transmission electron microscopy observation together demonstrated that Arabidopsis REM1.2 and REM1.3 are crucial for plasma membrane nanodomain assembly to control PD aperture and functionality. In addition, we also found that a 14-3-3 epsilon protein modulates REM clustering and membrane nanodomain compartmentalization through its direct interaction with REM proteins. This study unveils a molecular mechanism by which the key plant defense hormone, SA, triggers membrane lipid nanodomain reorganization, thereby regulating PD closure to impede virus spreading.

15.
Opt Lett ; 44(20): 5073-5076, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31613267

RESUMO

In this Letter, the femtosecond laser holographic two-photon polymerization (HTPP) method is adopted to rapidly realize a unique lab-in-a-needle (LIN) device by manufacturing microtube arrays inside a needle. The HTPP method is to modulate a Gaussian beam into a ring Bessel beam by a spatial light modulator (SLM) loaded with a Bessel hologram, and can fabricate microtube arrays with controllable inside diameter (1-10 µm) and designable patterns on such complex three-dimensional (3D) substrates by optimizing experimental parameters. A single LIN device can be processed by this method in about 4 min, which is not possible with traditional micronano technology and is much faster than the traditional two-photon polymerization method (at least several hours). To further demonstrate the functionality of this LIN device, a particle separation experiment is carried out. For the purpose of achieving greater functionality and integration of the on-chip system, this HTPP method provides a powerful processing method for integrating 3D functional microstructures on 3D nonplanar substrates.

16.
Proc Natl Acad Sci U S A ; 116(46): 23299-23308, 2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31659049

RESUMO

The atmosphere is vastly underexplored as a habitable ecosystem for microbial organisms. In this study, we investigated 795 time-resolved metagenomes from tropical air, generating 2.27 terabases of data. Despite only 9 to 17% of the generated sequence data currently being assignable to taxa, the air harbored a microbial diversity that rivals the complexity of other planetary ecosystems. The airborne microbial organisms followed a clear diel cycle, possibly driven by environmental factors. Interday taxonomic diversity exceeded day-to-day and month-to-month variation. Environmental time series revealed the existence of a large core of microbial taxa that remained invariable over 13 mo, thereby underlining the long-term robustness of the airborne community structure. Unlike terrestrial or aquatic environments, where prokaryotes are prevalent, the tropical airborne biomass was dominated by DNA from eukaryotic phyla. Specific fungal and bacterial species were strongly correlated with temperature, humidity, and CO2 concentration, making them suitable biomarkers for studying the bioaerosol dynamics of the atmosphere.

17.
J Pharm Sci ; 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31655033

RESUMO

Dexamethasone (DEX), a synthetic glucocorticoid, exhibited anti-cancer efficacy in pancreatic xenografts derived from patient tumor tissue or cancer cell lines. The aim of this study was to establish pharmacokinetic/pharmacodynamic (PK/PD) models to quantitatively characterize the inhibitory effect of DEX on tumor growth as well as its discrepancy among 3 xenograft models. Data of tumor growth profiles were collected from a patient-derived xenograft (PDX) model in NOD/SCID mice and 2 cell line-derived (PANC-1 and SW1990) xenograft models in BALB/c nude mice. Empirical PK/PD models were developed to establish mathematical relationships between plasma concentration of DEX and tumor growth dynamics after integrating PK parameters extracted from literature. Drug effect in each model was well described by a linear inhibitory function with a potency factor of 4.67, 3.14, and 2.35 L/mg for PDX, PANC-1, and SW1990 xenograft, respectively. Human efficacious doses of DEX were preliminarily predicted through model-based simulation, and 60% tumor growth inhibition at clinical exposure corresponded to a daily dose range of 26-52 mg intravenously. This modeling work quantified the preclinical anti-cancer effect of DEX and demonstrated the feasibility of its medication in pancreatic cancer, which would be conductive to future translational research.

18.
Lab Chip ; 19(23): 3988-3996, 2019 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-31663093

RESUMO

Smart devices made of stimuli-responsive (SR) hydrogel can realize accurate shape control with high repeatability attributed to their fast swelling and shrinking upon the change of external stimuli. Integrating these devices into microfluidic chips and utilizing their controllable deformation capability are highly promising approaches to enrich the functions of microfluidic devices and reduce their external apparatuses. Herein we propose and demonstrate a tunable microfluidic device (TMFD) by integrating a pH-sensitive hydrogel microring array into a microchannel. Instantaneous and reversible deformation of the microrings can be finished in less than 200 ms. The array gaps of the microrings are reversibly switched to realize the capture or release of microobjects. In addition, a femtosecond laser holographic processing method is firstly used to pattern and integrate the pH-sensitive hydrogel microrings into a microchannel, and the pH-responsive properties of the hydrogel affected by laser processing dosages are theoretically and experimentally investigated. With this method, the height, diameter (6-16 µm), swelling ratio (35-65%), and diameter change (2-5 µm) can be precisely controlled. As a proof of concept, the filtering of polystyrene particles with multiple sizes and complete trapping of PS particles and cells are demonstrated by these TMFDs. The developed TMFD can be easily integrated by the femtosecond laser holographic processing method, and operates robustly without the need for external precision apparatuses, which hold great promise in the applications of microobject manipulation and biomedical analysis.

19.
Int J Mol Sci ; 20(19)2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31574992

RESUMO

RING domain proteins generally have E3 ubiquitin ligase activity and are involved in degrading their substrate proteins. The roles of these proteins in growth, development, and responses to different abiotic stresses have been described well in various plant species, but little is available on tomatoes. Here, we identified 474 RING domains in 469 potential proteins encoded in the tomato genome. These RING genes were found to be located in 12 chromosomes and could be divided into 51 and 11 groups according to the conserved motifs outside the RING domain and phylogenetic analysis, respectively. Segmental duplication could be the major driver in the expansion of the tomato RING gene family. Further comparative syntenic analysis suggested that there have been functional divergences of RING genes during plant evolution and most of the RING genes in various species are under negative selection. Expression profiles derived from a transcriptomic analysis showed that most tomato RING genes exhibited tissue-specific expression patterning. Further RT-qPCR validation showed that almost all genes were upregulated by salt treatment, which was consistent with the microarray results. This study provides the first comprehensive understanding of the RING gene family in the tomato genome. Our results pave the way for further investigation of the classification, evolution, and potential functions of the RING domain genes in tomato.

20.
BMC Bioinformatics ; 20(1): 479, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31533622

RESUMO

BACKGROUND: The adverse reactions that are caused by drugs are potentially life-threatening problems. Comprehensive knowledge of adverse drug reactions (ADRs) can reduce their detrimental impacts on patients. Detecting ADRs through clinical trials takes a large number of experiments and a long period of time. With the growing amount of unstructured textual data, such as biomedical literature and electronic records, detecting ADRs in the available unstructured data has important implications for ADR research. Most of the neural network-based methods typically focus on the simple semantic information of sentence sequences; however, the relationship of the two entities depends on more complex semantic information. METHODS: In this paper, we propose multihop self-attention mechanism (MSAM) model that aims to learn the multi-aspect semantic information for the ADR detection task. first, the contextual information of the sentence is captured by using the bidirectional long short-term memory (Bi-LSTM) model. Then, via applying the multiple steps of an attention mechanism, multiple semantic representations of a sentence are generated. Each attention step obtains a different attention distribution focusing on the different segments of the sentence. Meanwhile, our model locates and enhances various keywords from the multiple representations of a sentence. RESULTS: Our model was evaluated by using two ADR corpora. It is shown that the method has a stable generalization ability. Via extensive experiments, our model achieved F-measure of 0.853, 0.799 and 0.851 for ADR detection for TwiMed-PubMed, TwiMed-Twitter, and ADE, respectively. The experimental results showed that our model significantly outperforms other compared models for ADR detection. CONCLUSIONS: In this paper, we propose a modification of multihop self-attention mechanism (MSAM) model for an ADR detection task. The proposed method significantly improved the learning of the complex semantic information of sentences.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Redes Neurais (Computação) , Semântica , Atenção , Humanos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA