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1.
ISA Trans ; 2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31488246

RESUMO

Recently, a robust least squares support vector machine (R-LSSVM) was proposed, but its computational complexity is very high compared with the traditional least squares support vector machine (LSSVM). To reduce R-LSSVM's computational complexity, an improved version, i.e., extended LSSVM (E-LSSVM), is developed in this paper. E-LSSVM and R-LSSVM are equivalent in terms of the generalization performance, but the former needs lower computational complexity than the latter. It is proved that the traditional LSSVM is a special case of E-LSSVM, and based on this fact, we know that the bias in the traditional LSSVM owns manifest physical meaning, i.e., the mean of the modeling error. To solve the mathematical model of E-LSSVM, two algorithms, DE-LSSVM (dual E-LSSVM) and PE-LSSVM (primal E-LSSVM), are proposed from dual and primal spaces, respectively. Even competing against the traditional LSSVM, DE-LSSVM takes the edge in term of the training time. In addition, the sparse problem and cross validation of DE-LSSVM are discussed as well. To verify the effectiveness and soundness of the proposed DE-LSSVM and PE-LSSVM, experiments on regression and classification problems are investigated. To be more important, DE-LSSM and PE-LSSVM are successfully applied to the fault diagnosis of aircraft engine, showing that they are eligible for potential techniques of the fault diagnosis of aircraft engine.

2.
J Craniofac Surg ; 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31503119

RESUMO

BACKGROUND: Port wine stain (PWS) is a congenital benign vascular malformation. Laser treatment is the main therapy for PWS. But some patients are not sensitive to it, and failed laser treatment will leave scars on face. Hence in this study, the authors used prefabricated flap carried by superficial temporal artery to treat PWS. METHODS: Nine patients diagnosed with large-scaled PWS (occupying more than half of the cheek) from January 2008 to December 2017 were selected in the study. One of them did not finish the treatment. Eight patients completed all scheduled treatments. In the first stage, superficial temporal vessels were transferred to the donor site and then an expander was implanted. About 80 to 150 days later, PWS was removed and the prefabricated flap was used to repair the wound. All the 8 patients were followed-up for 10 months to 36 months. RESULTS: Prefabricated flap survived well. All patients are satisfied with the appearance. The color and texture of prefabricated flap is similar to the surroundings. CONCLUSION: The combination of prefabricated flap and skin soft tissue expander not only extends the scale of flap but also enhances the efficacy of surgical treatment. It is a good candidate to treat PWS.

3.
Nanomedicine (Lond) ; 14(16): 2189-2207, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31411542

RESUMO

Aim: To develop a H2O2/near-infrared (NIR) laser light-responsive nanoplatform (manganese-doped Prussian blue@polypyrrole [MnPB@PPy]) for synergistic chemo/photothermal cancer theranostics. Materials & methods: Doxorubicin (DOX) was loaded onto the surface of polypyrrole shells. The in vitro and in vivo MRI performance and anticancer effects of these nanoparticles (NPs) were evaluated. Results: The MnPB@PPy NPs could not only generate heat under NIR laser irradiation for cancer photothermal therapy but also act as an excellent MRI contrast agent. The loaded DOX could be triggered to release by both NIR light and H2O2 to enhance synergistic therapeutic efficacy. The antitumor effects were confirmed by in vitro cellular cytotoxicity assays and in vivo treatment in a xenograft tumor model. Conclusion: The designed H2O2/NIR light-responsive MnPB@PPy-DOX NPs hold great potential for future biomedical applications.

4.
J Hazard Mater ; 381: 120977, 2019 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-31437802

RESUMO

Uranium-enriched coal ash (CA) receives a significant attention as a supplementary nuclear resource also due to its potential environmental risk. Combining with CA, the changing trend of uranium occurrence in synthetic coal ash (SCA) was described at CaO-Al2O3-Fe2O3 ternary phase diagrams with a fixed SiO2 (wt. %, 30%, 50% and 70%) and Na2O (2%) content. This study reveals that the mode of uranium occurrence proposes a three-stage changing process during coal combustion including uranium oxidation, combination and encapsulation. Furthermore, a high frequency of encapsulated uranium resulted from the complicated interactions among major components with a medium SiO2 content, whereas the degree was higher at a higher SiO2, resulting in the decrease of uranium mobility. Uranium was encapsulated by Si-Al matrix and Fe-Si depletion if provided the high Al2O3 and Fe2O3 but low CaO contents. However, with the development of calcium looping and biomass co-firing process, the change of element mobility should be considered in industry owing to the extra-added alkaline metals. As the activation of Ca2+ induces a significant susceptibility of acid attack, cautions must be paid in CA with a higher Ca/Si ratio to avoid its utilization as constructive materials for the potential environmental risk.

5.
Mol Oncol ; 2019 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-31420931

RESUMO

Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1), located on human chromosome 19q13.43, is a member of the C2H2 zinc finger protein family. Herein, we aimed to analyze the interactions between ZNF667-AS1, microRNA-93-3p (miR-93-3p), and paternally expressed gene 3 (PEG3), and to explore their roles in the tumorigenesis of cervical cancer (CC). Differentially expressed lncRNAs and miRNAs related to CC were determined using gene-expression datasets sourced from the GEO database. Subsequently, the regulatory relationships between ZNF667-AS1 and miR-93-3p and between miR-93-3p and PEG3 were identified using the dual luciferase reporter gene assay. In addition, the expression of miR-93-3p and ZNF667-AS1 was up- or down-regulated in CC cells (HeLa), in order to assess their effects on cell cycle distribution and cell invasion in vitro, and tumor growth and metastasis in vivo. MiR-93-3p was found to be highly expressed while ZNF667-AS1 and PEG3 were poorly expressed in CC. ZNF667-AS1 could competitively bind to miR-93-3p, which targeted PEG3. In addition, miR-93-3p down-regulation and ZNF667-AS1 overexpression led to increased expression of PEG3, TIMP-2 and p16, and decreased expression of Cyclin D1, MMP-2, and MMP-9. MiR-93-3p inhibition and ZNF667-AS1 elevation also inhibited cell cycle entry and cell invasion in vitro, but repressed tumor growth and metastasis in vivo. These key findings demonstrated that upregulation of ZNF667-AS1 could suppress the progression of CC via the modulation of miR-93-3p-dependent PEG3, suggesting a potential therapeutic target for the treatment of CC.

6.
Metab Brain Dis ; 2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-31363985

RESUMO

The hippocampus is a crucial pathological node for minimal hepatic encephalopathy (MHE) and it is associated with various cognitive impairments. Investigations on alterations involving hippocampal morphology and functional connectivity (FC) in MHE are limited. This study aimed to simultaneously evaluate hippocampal volume and FC alterations and their association with cognitive decline in MHE. Twenty-two cirrhotic patients with MHE, 31 cirrhotic patients without MHE (NHE), and 43 healthy controls underwent high-resolution T1-weighted imaging, resting-state functional magnetic resonance imaging, and cognition assessment based on Psychometric Hepatic Encephalopathy Score (PHES). The structural images were preprocessed using a voxel-based morphometry method, during which hippocampal volume was measured. The hippocampal connectivity network was identified using seed-based correlation analysis. Hippocampal volume and FC strength were compared across the three groups and correlated against the PHES results of the cirrhotic patients. Compared to the controls, MHE patients exhibited a significantly lower bilateral hippocampal volume. A slight decrease in hippocampal volume was obtained from NHE to MHE, but it did not reach statistically significance. In addition, the average FC strength of the bilateral hippocampal connectivity network was significantly lower in the MHE patients. In particular, the MHE patients showed a decrease in FC involving the left hippocampus to bilateral posterior cingulate gyrus and left angular gyrus. The MHE patients also showed FC reduction between the right hippocampus and bilateral medial frontal cortex. A progressive reduction in hippocampal FC from NHE to MHE was also observed. The bilateral hippocampal FC strength (but not hippocampal volume) was positively correlated with the PHES results of the cirrhotic patients. Our assessment of MHE patients revealed decreased hippocampal volume, which suggests regional atrophy, and reduced hippocampal connectivity with regions that are primarily involved in the default-mode network, thereby suggesting a functional disconnection syndrome. These alterations reveal the mechanisms underlying cognitive deterioration with disease progression.

8.
Artigo em Inglês | MEDLINE | ID: mdl-31331082

RESUMO

Ozone has become one of the most serious air pollutants in China in recent years. Since people spend most of their time indoors, the ozone in the indoor environment could be a major factor affecting the occupants' health. The indoor ozone in residential buildings mainly comes from two sources: outdoor atmosphere and indoor ozone produced by electrical devices. In this study, a typical residence in Nanjing was taken as an example to calculate and compare the contributions of indoor and outdoor sources to ozone in the building. A questionnaire survey about the type, the placement, and the frequency of use of the ozone emission devices was performed to provide the basis for the settings of indoor ozone sources. The multi-zone software CONTAM was used hourly to simulate the ozone concentration in summer and in winter with inner doors either closed or open, and it was noted whether there were ozone emission devices indoors or not. Source contribution was quantified and compared by three methods in this paper: (1) the average indoor/outdoor (I/O) ratio, (2) the I/O ratio frequency, and (3) the ratio of indoor ozone concentration without ozone sources to that with ozone sources. The results showed that the contribution of outdoor sources was much greater than that of indoor sources in summer, but in winter, the frequency of I/O > 1 could reach 55.8% of the total seasonal time, and the ratio of indoor ozone concentration without sources to that with sources could reach as high as 74.3%. This meant that the indoor concentration had the potential to exceed the outdoor. Furthermore, human respiratory exposure in different ages and genders was calculated. It was found that teenagers aged 10-18 years old and female adults had a higher respiratory exposure level.

9.
Anal Chem ; 91(16): 10894-10900, 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31331163

RESUMO

Acrylate has been widely used as the recognition unit for Cys fluorescent probes. Despite this widespread use, a potential drawback of this probe type is that the ester linkage between the fluorophore and acryloyl recognition unit is liable to be hydrolyzed by abundant esterase in the cytosol, thus affording a high background signal. To solve this problem, we herein put forward a new strategy to construct a selective fluorescent probe for cysteine (Cys)/homocysteine (Hcy) with propynamide as the recognition moiety. The free probe CPA displays weakly fluorescent emission in aqueous media because of the donor-excited photoinduced electron transfer (d-PET) process within the molecule. The Michael addition of Cys (or Hcy) thiols to the conjugated alkyne of CPA gives the expected ß-sulfido-α,ß-unsaturated amides (1a/1b), which subsequently undergo an intramolecular S,N rearrangement, yielding ß-amino-α,ß-unsaturated amides (2a/2b) as the final products. The above cascade reaction results in the blockage of d-PET within CPA, thus affording a dramatic fluorescence enhancement at 495 nm. The involvement of the sulfhydryl and the adjacent amino groups in the sensing process renders CPA high selectivity for Cys/Hcy over glutathione as well as other amino acids. The probe has been successfully applied to image Cys in different cell lines. Further, CPA shows two-photon fluorescence properties, and its ability to monitor Cys in deep tissues has been demonstrated by using two-photon microscopy.

10.
Target Oncol ; 14(4): 369-374, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31301016

RESUMO

BACKGROUND: The third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib has demonstrated significant clinical benefit in EGFR T790M-mutated non-small-cell lung cancer (NSCLC) patients, with extensive research focusing on the mechanisms of acquired resistance. However, there are limited studies on second-line treatment options for EGFR T790M-negative patients and their clinical outcomes. OBJECTIVE: We aimed to provide better understanding of the resistance mechanisms to osimertinib treatment as well as the therapeutic options for T790M-negative NSCLC patients. PATIENTS AND METHODS: In this case study, a patient was admitted and diagnosed with stage IV lung adenocarcinoma. Tissue specimen and blood samples collected from baseline and during the course of treatment were subjected to genomic profiling of 416 cancer-related genes using hybridization capture-based targeted next-generation sequencing. RESULTS: Following progression on initial chemoradiotherapy, the patient received EGFR TKI treatment with icotinib upon the confirmation of carrying an EGFR L858R mutation. However, the patient was negative for the EGFR T790M mutation when he became resistant to icotinib. The patient received subsequent osimertinib treatment and achieved a progression-free survival (PFS) of 10.4 months. Upon disease progression, an acquired L718V mutation within the EGFR kinase domain was found, which may interfere with the binding of osimertinib to the kinase domain and confer resistance regardless of T790M status. CONCLUSIONS: This is the first clinical evidence of EGFR L718V giving rise to osimertinib resistance in a T790M-negative context, which provides valuable information for the discovery of resistance mechanisms to osimertinib and guidance for personalized NSCLC treatment in such patients.

11.
Adv Mater ; 31(37): e1901077, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31339199

RESUMO

Twisting between two stacked monolayers modulates periodic potentials and forms the Moiré electronic superlattices, which offers an additional degree of freedom to alter material property. Considerable unique observations, including unconventional superconductivity, coupled spin-valley states, and quantized interlayer excitons are correlated to the electronic superlattices but further study requires reliable routes to study the Moiré in real space. Scanning tunneling microscopy (STM) is ideal to precisely probe the Moiré superlattice and correlate coupled parameters among local electronic structures, strains, defects, and band alignment at atomic scale. Here, a clean route is developed to construct twisted lattices using synthesized monolayers for fundamental studies. Diverse Moiré superlattices are predicted and successfully observed with STM at room temperature. Electrical tuning of the Moiré superlattice is achieved with stacked TMD on graphite.

12.
Dis Markers ; 2019: 9802839, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31354895

RESUMO

Background: It has been suggested that mesangial IgA deposits are dimeric or polymeric in IgA nephropathy (IgAN). However, evidence concerning the molecular form of serum IgA in IgAN is controversial. And there is no direct evidence that the serum levels of joining chain- (J chain-) containing IgA (J-IgA) are elevated in IgAN. In this study, we aimed to measure serum J-IgA and glomerular J chain deposition with anti-J chain monoclonal antibody in IgAN. Methods: BALB/c mice were immunized with human J chain-GST recombinant peptide to obtain anti-J chain monoclonal antibody. The levels of serum total IgA and J-IgA were measured by sandwich enzyme-linked immunosorbent assay in 115 patients with IgAN and 117 healthy volunteers. J chain deposition in kidney specimens was analyzed by immunohistochemistry staining. Results: Serum levels of total IgA1 were elevated in IgAN patients compared to healthy subjects. However, serum levels of IgA, J-IgA, and J chain-containing IgA1 (J-IgA1), the J-IgA to total IgA ratio, and the J-IgA1 to total IgA1 ratio were not significantly different between IgAN patients and healthy subjects. Western blot analysis and gel filtration analysis using purified IgA1 also showed that the proportion of J chain-containing polymeric IgA1 was lower in IgAN patients compared to healthy subjects. No correlation was found between serum J-IgA or J-IgA1 and clinical features in IgAN. Immunohistochemistry analysis showed that glomerular J chain was positive in 12 IgAN patients (57.1%). The values of the J-IgA to IgA ratio and J-IgA1 to IgA ratio were significantly higher in IgAN patients with glomerular J chain deposition than those without. However, the serum levels of J-IgA and J-IgA1 and the J-IgA1 to IgA1 ratio were not significantly higher in two subgroups. Conclusions: Although serum levels of total IgA1 were elevated in IgAN, the serum levels of J-IgA1 were not elevated. And serum J-IgA, serum J-IgA1, and J chain deposition were not correlated with disease severity in IgAN.

13.
Talanta ; 204: 29-35, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31357296

RESUMO

Because STAT3 is a potent proto-oncogene, screening STAT3 gene has potential for use in tumor diagnosis, classification of subtypes, and molecular target therapy. Thus, in this study, using STAT3 gene as the model molecule, we developed a novel amplification strategy, ultrasensitive rolling circle amplification (THP-RCA) based on target-catalyzed hairpin structure-mediated padlock cyclization, for the ultrasensitive detection of human proto-oncogenes in a homogenous solution. In this system, HP1 was designed as the cyclization template and RCA reaction primer, while HP2 was the padlock probe. The two probes can fold into a hairpin structure via the self-hybridization and thus lock the signaling process in the absence of target species. The hybridization of HP2 with HP1 in an end-to-end fashion occurs with the help of target DNA. Subsequently, HP2 is cyclized by ligase on HP1 template. Interestingly, during the hybridization and enzymatic cyclization of HP2, the target DNA only serves as the catalytic probe and is not exhausted. The cyclized HP2 enables the rolling circle amplification, generating a long tandem single-stranded (ss) DNA product that is capable of hybridizing with considerable quantity of molecular beacons (MBs). As a result, the dramatically amplified fluorescence value is achieved for the ultrasensitive detection of the STAT3 gene. As a result, target DNA is able to be quantified down to 100 fM with a high specificity towards wild-type target DNA. Moreover, the sensing system is suitable for the target detection in human serum. The novel sensing strategy shows tremendous prospect for application in tumor diagnosis and clinical therapy guidance.

14.
J Colloid Interface Sci ; 552: 418-425, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31151019

RESUMO

This study reports highly permeable ultrathin film composite (uTFC) membranes whose rejection layer was reinforced by polymer chains during the interfacial polymerization of trimesoyl chloride (TMC) and m-phenylenediamine (MPD) to achieve enhanced salt rejection. A rejection layer of approximately 20 nm was formed at an MPD concentration of 0.01 wt%. This reinforced membrane had a water permeability of about 16.7 L/(m2 h bar), while exhibiting an improved divalent salt (Na2SO4) to monovalent salt (NaCl) selectivity compared with the control TFC membrane without reinforcement (3.44 vs. 1.06). The role of the reactable polymer chains in interfacial polymerization was discussed as MPD adsorbent and reactant, according to the measurements by quartz crystal microbalance and X-ray photoelectron spectroscopy. This work provides a new pathway for the design and construction of uniform ultrathin layers as well as the preparation of high performance separation membranes.

15.
Hypertens Res ; 2019 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-31235845

RESUMO

Fumarase insufficiencies can increase reactive oxygen species (ROS). This study will further dissect the imbalance of redox metabolism and the mechanism of ROS production using proteomic technology in fumarase knockdown HK-2 cells. The contribution of fumarase was further confirmed by supplementation of fumarate and malate in Dahl salt-sensitive rats. Proteomic analysis indicated that fumarase knockdown in HK-2 cells changed the expression or activity of NADPH oxidase (NOX), mitochondrial respiratory chain Complex I and III, ATP synthase subunits, and α-oxoglutarate dehydrogenase (OGDH). Meanwhile, the activities of key antioxidant enzymes, including glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, glutathione reductase, glutathione peroxidase, and glutathione S-transferase, increased significantly. The apparent activation of antioxidant defense appeared insufficient as the glutathione and GSH/GSSG ratio were decreased significantly. Dahl salt-sensitive rats exhibited changes in redox metabolism similar to HK-2 cells with fumarase knockdown. Supplementation with fumarate and malate increased and decreased, respectively, blood pressure and H2O2 and malondialdehyde in salt-sensitive rats. These results indicated that insufficient fumarase activity increased ROS by regulating NOX, Complex I and III, ATPase alpha, and OGDH and the imbalance of glutathione metabolism, which may be one of the main reasons for salt-sensitive hypertension. Malate may be a potentially effective drug for the prevention and treatment of salt-sensitive hypertension.

16.
Environ Sci Pollut Res Int ; 26(20): 20277-20285, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31098910

RESUMO

The sorption/desorption behaviors of benzene, toluene, ethylbenzene, and xylene (BTEX) on soil organic matter (SOM) have a significant influence on their fate and bioavailability in soil. Humic acid (HA) is a major fraction of SOM. And due to its various structural properties and chemical composition, the sorption/desorption characteristics and mechanisms of HA are diverse for organic contaminants. In this study, batch experiments were conducted to investigate the sorption/desorption behavior of benzene on HA at different conditions (temperature, pH, and ionic strength). The particle size of HA increased at lower initial pH which promoted sorption capacity for benzene, illustrating that HA with larger particle size may develop preferential chemical conformation for benzene sorption at lower pH. Sorption isotherms indicated that the sorption of benzene on HA is an exothermic and spontaneous physical process. And kinetic studies showed that the sorption of benzene on HA is controlled by the diffusion process and the availability of sorption sites. Meanwhile, weak sorbent-sorbate interaction is presented in the desorption experiment. There was no obvious effect of ionic strength on benzene sorption, suggesting that the sorption process is not controlled by ion-exchange or electrostatic interaction. Combined with FTIR analysis, the hydrophobic partitioning and π-π conjugative interaction are the possible sorption mechanisms of benzene on HA.


Assuntos
Benzeno/análise , Substâncias Húmicas/análise , Poluentes do Solo/análise , Solo/química , Adsorção , Concentração de Íons de Hidrogênio , Interações Hidrofóbicas e Hidrofílicas , Cinética , Concentração Osmolar , Tamanho da Partícula
17.
Prostate ; 79(10): 1166-1179, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31135075

RESUMO

BACKGROUND: The progression of castration-resistant prostate cancer (CRPC) still relies on the function of androgen receptor (AR), achieved by evolving mechanisms to reactivate AR signaling under hormonal therapy. Histone deacetylase inhibitors (HDACis) disrupt cytoplasmic AR chaperone heat shock protein 90 (Hsp90) via HDAC6 inhibition, leading to AR degradation and growth suppression of prostate cancer (PCa) cells. However, current HDACis are not effective in clinical trials treating CRPC. METHODS: We designed hybrid molecules containing partial chemical scaffolds of AR antagonist enzalutamide (Enz) and HDACi suberoylanilide hydroxamic acid (SAHA) as new anti-PCa agents. We previously demonstrated that Enz-HDACi hybrid drug 2-75 targets both AR and Hsp90, which inhibits the growth of Enz-resistant C4-2 cells. In the current study, we further investigate the molecular and cellular actions of 2-75 and test its anti-PCa effects in vivo. RESULTS: Compared with Enz, 2-75 had greater AR antagonistic effects by decreasing the stability, transcriptional activity, and nuclear translocation of intracellular AR. In addition to inhibition of full-length AR (FL AR), 2-75 downregulated the AR-V7 variant in multiple PCa cell lines. Mechanistic studies indicated that the AR affinity of 2-75 retains the drug in the cytoplasm of AR + PCa cells and further directs 2-75 to the AR-associated protein complex, which permits localized effects on AR-associated Hsp90. Further, unlike pan-HDACi SAHA, the cytoplasm-retaining property allows 2-75 to significantly inhibit cytoplasmic HDAC6 with limited impact on nuclear HDACs. These selective cytoplasmic actions of 2-75 overcome the unfavorable resistance and toxicity properties associated with classical AR antagonists, HDACis, and Hsp90 inhibitors. Finally, 2-75 showed greater antitumor activities than Enz in vivo on SQ xenografts derived from LNCaP cells. CONCLUSIONS: Novel therapeutic strategy using newly designed 2-75 and related AR antagonist-HDACi hybrid drugs has great potential for effective treatment of CRPC.

18.
Hepatobiliary Pancreat Dis Int ; 18(3): 223-227, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31056483

RESUMO

BACKGROUND: Lower mean platelet volume (MPV) is an indicator of platelet activity in the setting of tumor development. This study was to assess the relationship between preoperative MPV and survival outcomes of patients with hepatocellular carcinoma (HCC) following liver transplantation (LT). METHODS: The demographic and clinical characteristics of 304 HCC patients following LT were retrieved from an LT database. All the patients were divided into the normal and lower MPV groups according to the median MPV. The factors were first analyzed using a Kaplan-Meier survival analysis, then the factors with P < 0.10 were selected for multivariate Cox regression analysis and were used to define the independent risk factors for poor prognosis. RESULTS: The 1-, 3-, and 5-year tumor free survival was 95.34%, 74.67% and 69.29% in the normal MPV group, respectively, and 95.40%, 59.97% and 42.94% in the lower MPV group, respectively (P < 0.01). No significant difference was observed in post-LT complications between the normal and lower MPV groups. Portal vein tumor thrombosis (PVTT) [hazard ratio (HR = 2.24; 95% confidence interval: 1.46-3.43; P < 0.01) and lower MPV (HR = 1.58; 95% confidence interval: 1.05-2.36; P = 0.03) were identified as independent prognostic risk factors for recipient survival. CONCLUSION: Preoperative lower MPV is a risk indicator of HCC patients survival outcomes after LT.

19.
ACS Appl Mater Interfaces ; 11(21): 19462-19471, 2019 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-31071260

RESUMO

Pressure retarded osmosis (PRO) process is hindered by severe fouling occurring within the porous support of the forward osmosis (FO) membranes. We designed a novel double-skinned FO membrane containing a polyamide salt-rejecting layer and a zwitterionic brush-decorated, multiwalled carbon nanotube (MWCNT/PSBMA) foulant-resisting layer on the back side. Our results demonstrated that the coating of the MWCNT/PSBMA layer on the porous polyketone (PK) support imparted enhanced hydrophilicity and smaller membrane pore size, thereby providing excellent resistance toward both protein adhesion and bacterial adsorption. We also further evaluated this resultant double-skinned membrane (i.e., TFC-MWCNT/PSBMA) in dynamic PRO fouling experiments using protein and alginate as model organic foulants. Compared to the pristine TFC-PK and hydrophobic TFC-MWCNT membranes, the TFC-MWCNT/PSBMA membrane exhibited not only the lowest water flux decline but also the highest water flux recovery after simple physical flushing. These results shed light on fabrication of antifouling PRO membranes for water purification purposes.

20.
Langmuir ; 35(24): 7713-7719, 2019 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-31122020

RESUMO

In this work, a closed thermoelectric cell based on a nanoporous graphene electrode is developed to convert low-grade thermal energy to electric energy. The thermoelectric cell consists of two nanoporous graphene electrodes in contact with the hot and cold ends, respectively, encapsulated in a KCl electrolyte, and the energy is harvested from the redistribution of the electric double layer (EDL) of the graphene electrodes under different temperatures. Because of the large specific surface and conductivity of nanoporous graphene electrodes, the electric voltage is 168.91 mV with the hot-end temperature of 61 °C and cold-end temperature of 26 °C, corresponding to the thermoelectric coefficient of 4.54 mV·°C-1, which is much larger than that of the conventional thermoelectric generator. The specific power output achieves 1.38 mW·g-1 and is also significantly larger than the previous EDL-based thermoelectric generator. System performance with the concentration of the KCl electrolyte is examined. The proposed thermoelectric cell can harvest low-grade waste heat from the ambient environment, which may have potential applications in energy supply, wireless powered devices, outdoor survival, and so forth.

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