Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 567
Filtrar
1.
Artigo em Inglês | MEDLINE | ID: mdl-31711259

RESUMO

Background and Aims Comprehensive investigations on the prothrombotic factors of splanchnic vein thrombosis (SVT), including Budd-Chiari syndrome (BCS) and noncirrhotic nonmalignant portal vein thrombosis (PVT), in Eastern patients are scarce. METHODS: Between March 2012 and July 2017, 812 consecutive patients, including 418 BCS and 394 noncirrhotic nonmalignant PVT patients, were admitted to Xijing Hospital (a Chinese tertiary academic hospital) and screened for prothrombotic factors. Odds ratios (ORs), 95% confidence intervals (CIs) and P-trends were calculated by using conditional logistic regression. RESULTS: The prevalence of myeloproliferative neoplasms (MPNs) was only 6.3% among BCS patients but 28.3% among PVT patients. Notably, the presence of MPNs was associated with a higher risk of hepatic vein (HV)-type BCS (OR 9.9, 95% CI 3.6-26.7, P-trend <0.001) and extensive thrombosis in PVT (OR 4.1, 95% CI 1.9-8.9, P-trend <0.001). Calreticulin (CALR) mutations existed in 2.7% of SVT patients. Furthermore, the prevalence of antiphospholipid antibody syndrome (APS) and protein C, protein S, or antithrombin deficiency in BCS patients was 7.3% and 22.5%, respectively, similar to that in patients with PVT (7.4% and 25.7%). In addition, factor V Leiden (FVL) mutation, prothrombin G20210A mutation, and paroxysmal nocturnal hemoglobinuria (PNH) were identified in <1% of both BCS and PVT patients. CONCLUSION: There is a significant positive association between MPNs and HV-type BCS or noncirrhotic nonmalignant PVT with extensive thrombosis. Additionally, CALR mutations should be tested in JAK2V617F -negative SVT patients in China. However, screening for FVL mutation, prothrombin G20210A mutation and PNH may be unnecessary.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31696400

RESUMO

The main goal of this study is to measure the ambient air of total suspended particulates at a mixed (traffic, residential and commercial) sampling site. And the concentrations of phthalate acid ester (PAE) which attached on total suspended particles were also analyzed. In addition, the possible sources of PAEs were also analyzed by the method of back trajectories. Finally, appropriate statistical methods were also used to test monthly and seasonal mean pollutants' (particulates, PAEs) concentration differences at this sampling site. The results indicated that the monthly concentration variation trends were similar for DEHP and total PAEs with the results as followed: November > October > July > December > September. In addition, back trajectories results also indicated that the main pollutant parcels were came from the east side of Taiwan in July. And the pollutant parcels were came from the north side of Taiwan during the month of September, October, November and December in this study. Moreover, the results also showed that the DEHP, DNOP, total PAEs' concentrations with TSP and meteorological conditions were not significantly different. But the relationship among DEHP, DNOP and total PAEs was significantly different; particularly, the relationship between DEHP and total PAEs was highly correlated in this study (R2 = 0.994). Finally, the statistical analysis of total PAEs T test statistic for mean monthly concentrations results suggested that the sample population means were not differed significantly. In other words, there were not any mean monthly concentration differences for PAEs at this sampling site. The only exception was occurred in the month of September versus November. The results showed that there is a statistically significant PAEs' concentration difference between the input groups (September vs. November).

3.
Chin J Nat Med ; 17(10): 785-791, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31703759

RESUMO

One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25 µmol·L-1.

4.
Anal Chem ; 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31755263

RESUMO

Fluorescence molecular imaging has attracted more and more attention due to its various advantages. Lots of fluorophores have been developed to meet various molecular imaging needs. However, it is still inconvenient due to lack excellent fluorophores with an optically tunable group for biological molecular imaging. Here, a new platform of the versatile long wavelength fluorophore with an optically tunable hydroxyl group was successfully developed by regulating molecular planarity and twisted intramolecular charge transfer effect with protected and deprotected-hydroxyl group approach via "step by step" modifying strategy. As an excellent representative of this new type fluorophore, LDOH-4 performs good chemical and optical properties, and shows a potential application prospect. As a proof-of-concept, a nitroreductase-activated TP fluorescent probe LDO-NTR was designed, which not only sensitively recognize NTR with more than 310-fold response signal enhancement in vitro, but also tracking NTR in hypoxia tumor mouse in vivo by using two-photon imaging. It is hopeful that the long wavelength fluorophore with the optically tunable hydroxyl group can serve as a useful platform to extend capable detection tools in biological chemistry and biomedical applications.

5.
Clin Chim Acta ; 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31733195

RESUMO

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disease characterized by clinical or laboratorial hyperandrogenism, oligo-anovulation and metabolic abnormalities, including insulin resistance, excessive weight or obesity, type II diabetes, dyslipidemia and an increased risk of cardiovascular disease. The most significant clinical manifestation of PCOS is hyperandrogenism. Excess androgen profoundly affects granulosa cell function and follicular development via complex mechanisms that lead to obesity and insulin resistance. Most PCOS patients with hyperandrogenism have steroid secretion defects that result in abnormal folliculogenesis and failed dominant follicle selection. Hyperandrogenism induces obesity, hairy, acne, and androgenetic alopecia. These symptoms can bring great psychological stress to women. Drugs such as combined oral contraceptive pills, metformin, pioglitazone and low-dose spironolactone help improve pregnancy rates by decreasing androgen levels in vivo. Notably, PCOS is heterogeneous, and hyperandrogenism is not the only pathogenic factor. Obesity and insulin resistance aggravate the symptoms of hyperandrogenism, forming a vicious cycle that promotes PCOS development. Although numerous studies have been conducted, the definitive pathogenic mechanisms of PCOS remain uncertain. This review summarizes and discusses previous and recent findings regarding the relationship between hyperandrogenism, insulin resistance, obesity and PCOS.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31677186

RESUMO

BACKGROUND AND AIM: Treatment modalities of variceal bleeding or rebleeding for extrahepatic portal vein obstruction (EHPVO) are limited and their long-term results and prognostic factors are unclear. This study aimed at assessing the long-term results of EHPVO treated with current recommendations and investigating the influencing factors. METHODS: Between 2009 and 2016, 302 consecutive patients with EHPVO were included. Watch-and-wait policy was applied for those with no (n=59) or small varices (n=55), nonselective beta-adrenergic blocker (NSBB) and NSBB plus endotherapy were for primary (n=115) and secondary prophylaxis (n=87), transjugular intrahepatic portosystemic shunt (TIPS) or combination therapy was for those with recurrent bleeding (n=92). RESULTS: The median follow-up was 58.8 months. The 1-, 3-, and 5-year cumulative rates were 3.6%, 19.2%, 32.3% for small varices development and 4.5%, 30.9%, 53.4% for large varices development. The 1-, 3-, and 5-year cumulative rates were 11.1%, 20.9%, 34.9% for first variceal bleeding and 16.0%, 26.9%, 33.6% for variceal rebleeding. For those with recurrent variceal bleeding, only TIPS (n = 37, technical success rate: 90.2%) was associated with a reduced risk of variceal rebleeding (1-, 3-, 5-year: 5.6%, 11.7%, 21.9%). The 1-, 3-, and 5-year survival rates were 96.9%, 95.8%, 91.9%. Prothrombotic factors and anticoagulation did not influence the risk of variceal bleeding, rebleeding and survival. CONCLUSIONS: By applying the same variceal management as recommended for patients with liver cirrhosis, patients with non-cirrhotic EHPVO showed a similar development of varices and variceal bleeding. This is also true for the beneficial effect of TIPS to prevent rebleeding.

7.
Chemosphere ; 236: 124886, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31564425

RESUMO

Managed aquifer recharge with reclaimed water is a promising strategy for indirect potable reuse. However, residual contaminants in the treated wastewater effluent could potentially have adverse effects on human health. Hence, adequate water pretreatment is required. A multi-criteria approach was used to select and evaluate suitable water pretreatment technologies that can remove these critical contaminants in wastewater effluent for MAR identified in a previous study (Yuan et al., 2017). The treatment efficiency targets were calculated based on the concentrations and the suggested limits of critical contaminants. Treatment efficiency credits were then assigned to each treatment option for the removal of critical contaminants based on literature data. Treatment units that resulted in the highest efficiency credit scores were selected and combined into treatment train options, which were evaluated in terms of treatability, cost, and sustainability. This paper proposes an approach for the selection and evaluation of water treatment options, which will be helpful to guide the future implementation of MAR projects with reclaimed water.

8.
Artigo em Inglês | MEDLINE | ID: mdl-31614177

RESUMO

Longistyline A (LLA), an abundant stilbene form the leaves of Cajanus cajan (L.) Millsp, was isolated. However, the antibacterial effect of LLA was still not understood. A detailed investigation of LLA against bacterial, particularly Methicillin-resistant Staphylococcus aureus (MRSA), was conducted. In vitro, LLA exhibited strong antibacterial activities against MRSA with the minimum inhibitory concentration (MIC) of 1.56 µg/mL and displayed much more rapid bactericidal efficacy (a 3-log decrease in MRSA cell-survival curve within 8 h) than that of vancomycin. The membrane-targeting experiment implied that antibacterial capability of LLA was associated with the perturbation of bacterial membrane potential and permeability. Notably, LLA had relatively weak cytotoxicity to murine macrophage cells (IC50 = 8.61± 0.57 µg/mL). In vivo, topical treatment of the injury with LLA improved wound healing and closure in a MRSA-infected wound healing mouse model consisting of 48 mice. After 3 days treatment, LLA decreased MRSA bacterial counts in the wounded region, reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α (180.74±10.78 vs. 606.57±68.99 pg/mL) and IL-6 (87.25±10.19 vs.280.58±42.27 pg/mL) in serum .

9.
World Neurosurg ; 133: 248-252, 2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31629148

RESUMO

BACKGROUND: Persistent idiopathic facial pain is characterized by persistent facial or oral pain in the absence of a neurologic deficit. This underexplored pain may be conducted by various nerves, including cranial nerves and upper cervical spinal roots, and its etiology is unclear. CASE DESCRIPTION: A patient presented with persistent idiopathic facial pain associated with occipital muscle stiffness after an improper neck massage. The patient achieved almost complete pain relief by coblation of right upper cervical nerves (C1 and C2 spinal roots) followed by continuous cervical epidural analgesia for a period of 3 weeks. The analgesic effect was stable during the 3-month follow-up period. CONCLUSIONS: Persistent idiopathic facial pain may be cervicogenic, and treatments focusing on cervical spinal roots may provide satisfactory pain control in patients with cervical abnormalities.

10.
Biosci Rep ; 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31658356

RESUMO

BACKGROUND: Obesity is a common heritable trait and a major risk factors of chronic and metabolic diseases. Insulin-induced gene 1 (INSIG1) is known to play important roles in cholesterol and  triacylglycerol (TAG) metabolism. In present study, our primary objective was to explore whether the single nucleotide polymorphisms (SNPs) in INSIG1 gene were associated with obesity in Uygur subjects, in Xinjiang, China. METHODS: We designed a case-control study including 516 obese patients and 463 age- and sex-matched control subjects. Three SNPs (rs2721, rs9767875 and rs9719268) were genotyped using TaqMan SNP genotyping assays. RESULTS: For rs2721, the distribution of genotypes, dominant model (GT + TT vs GG), recessive model (TT vs GT + GG) showed significant differences between obese patients and the controls (P = 0.008, P = 0.005 and P = 0.035 respectively). For rs9719268, the distribution of genotypes showed significant differences between obese patients and the controls (P = 0.004). The dominant model (GT + TT vs GG) of rs2721 and rs9719268 GT genotype remain significantly associated with obesity  after adjustment for confounders (OR = 1.393, 95% CI = 1.047-1.853, P = 0.023; OR = 1.631, 95% CI = 1.059-2.512, P = 0.026). The TG levels were significantly higher in rs2721 GT/TT genotypes than that in GG genotypes (P < 0.05).  Conclusions: Rs2721 and rs9719268 of INSIG1 gene are associated with obesity in Uygur subjects. Subjects with GT/TT genotype or T allele of rs2721 and GT genotype of rs9719268 were associated with an increased risk of obesity.

11.
Ophthalmic Genet ; 40(4): 309-312, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31512979

RESUMO

Objective: The aim of this study was to investigate genetic factors associated with idiopathic choroidal neovascularization (ICNV). Methods: We conducted a case-control study including 69 cases with ICNV and 114 controls who underwent cataract surgery. Single nucleotide polymorphisms (SNPs) from genes reported to be related to AMD, CNV and uveitis were selected for this study. Results: In an univariate analysis, the rs669676 SNP located in the COL8A1 gene was associated with the proportion of people who has idiopathic CNV ( X2 = 9.3453, corrected p-value = 0.1). For the rs669676 SNP, minor allele homozygotes, in the dominant model of genotype analysis (GG versus AA-GA), it showed significant differences in the ICNV group vs controls (p = .01, OR = 1.219 (95%CI: 1.04-1.429)). Conclusions: The rs669676 SNP located in the COL8A1 gene may contribute to a genetic susceptibility for ICNV.

12.
Brain Res ; 1724: 146430, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31479649

RESUMO

BACKGROUND: Vitamin D (VD) has important neuroprotective functions in the central nervous system. However, further exploration is still needed in the neuroprotective effects of VD monomer therapy on global cerebral ischemia (GCI) and its potential molecular mechanism. OBJECTIVE: To investigate whether calcitriol, a biologically active metabolite of VD, could alleviate cognitive impairment induced by GCI via reducing cell apoptosis and activating the extracellular signal-regulated kinase (ERK) signaling pathway. METHODS: A total of 145 adult male Sprague Dawley rats were randomly divided into five groups: Sham group (n = 45), GCI group (n = 45), calcitriol treatment group (GCI + calcitriol, n = 45), PD98059 treatment group (n = 5) and vehicle group (n = 5). Morris water maze test was used for evaluating spatial learning and memory functions. Neurological Severity Score and wet-dry weight method were applied to detect neurological deficits and brain water content, respectively. Hematoxylin and eosin staining, transmission electron microscopy, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end-labeling staining were performed for evaluating the changes of hippocampal CA1 neurons. Immunocytochemistry, immunofluorescence chemistry, and western blot analysis were performed for evaluating the changes of related proteins. RESULTS: Calcitriol significantly ameliorated the spatial learning and memory impairments, improved neurological function, attenuated brain edema, and improved the morphological defects in the CA1 area of the hippocampus. Besides, calcitriol reduced GCI-induced cell apoptosis and reversed the up-regulation of pro-apoptotic proteins (Caspase-3 and Bax) and the down-regulation of anti-apoptotic protein (Bcl-2). Furthermore, calcitriol also increased the expression of VD receptors (VDR) and activated the ERK signaling pathway. Moreover, the p-ERK1/2 inhibitor PD98059 reversed the effect of calcitriol on the expression of apoptosis-related proteins. CONCLUSIONS: Calcitriol may have a protective effect against GCI-induced cognitive impairments via inhibition of apoptotic cascade by activating the VDR/ERK signaling pathway.

13.
Anal Chem ; 91(16): 10361-10365, 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31373202

RESUMO

Hydrogen evolution reaction (HER) catalyzed by molybdenum sulfide quantum dots (MoS2 QDs) has attracted extensive attention in the energy field. Monitoring HER catalyzed by MoS2 QDs based on a glass nanopore with an electrochemically confined effect was proposed for the first time. MoS2 QDs inside the glass nanopore is driven toward the orifice of the nanopore and bonded with the Ag nanoparticles (Ag NPs) to form a single nanocomposite. When enough voltage is applied across the orifice, the single Ag NP acts as a single nanoparticle electrode to conduct the electrochemically bipolar reaction on its two extremities. In the process, HER is catalyzed by MoS2 QDs, and Ag NPs are oxidized at the same time. The appearance of blockages on the elevated ionic current is attributed to the generation of a H2 bubble. Furthermore, by analyzing the modulations in the ionic current oscillation, the frequency of hydrogen bubble generation that is related to the catalytic efficiency of MoS2 QDs could be estimated. The results reveal the capability of the glass nanopore for the real-time monitoring electrocatalytic behavior, which makes the glass nanopore an ideal candidate to further reveal the heterogeneity of catalytic capability at the single particle level.

14.
Plant Cell Environ ; 2019 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-31373013

RESUMO

The role of flowering in root-fungal symbiosis is not well understood. Because flowering and fungal symbionts are supported by carbohydrates, we hypothesized that flowering modulates root-beneficial fungal associations through alterations in carbohydrate metabolism and transport. We monitored fungal colonization and soluble sugars in the roots of Arabidopsis thaliana following inoculation with a mutualistic fungus Phomopsis liquidambari across different plant developmental stages. Jasmonate signalling of wild-type plants, sugar transport, and root invertase of wild-type and jasmonate-insensitive plants were exploited to assess whether and how jasmonate-dependent sugar dynamics are involved in flowering-mediated fungal colonization alterations. We found that flowering restricts root-fungal colonization and activates root jasmonate signalling upon fungal inoculation. Jasmonates reduce the constitutive and fungus-induced accumulation of root glucose and fructose at the flowering stage. Further experiments with sugar transport and metabolism mutant lines revealed that root glucose and fructose positively influence fungal colonization. Diurnal, jasmonate-dependent inhibitions of sugar transport and soluble invertase activity were identified as likely mechanisms for flowering-mediated root sugar depletion upon fungal inoculation. Collectively, our results reveal that flowering drives root-fungus cooperation loss, which is related to jasmonate-dependent root soluble sugar depletion. Limiting the spread of root-fungal colonization may direct more resources to flower development.

15.
Medicine (Baltimore) ; 98(35): e16703, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31464901

RESUMO

Although the electronic cross-matching of blood has been widely applied in some developed countries and regions, concern over the risk of undetected red blood cell (RBC) antibodies has limited its application in mainland China.This study was performed to explore the missed detection rate of RBC antibodies in a Chinese population from 2011 to 2016. If the results of 2 consecutive tests of ABO/RhD blood group identification were consistent and antibody screening results were negative, electronic cross-matching of the blood was performed. In addition, traditional serological cross-matching of blood (polybrene method) and a parallel experiment for electronic cross-matching of blood were performed to analyze the missed detection of unexpected RBC antibodies in blood donors and recipients.Using the polybrene method, 40,228 blood samples were tested by parallel traditional serological cross-matching of blood; among these samples, blood compatibility was found in 40,222 cases, primary incompatibility (incompatibility of the donor's erythrocytes with the recipient's serum) was found in 6 cases, and no secondary incompatibility was found. Identification of antibody specificity was performed using panel cells, and all unexpected RBC antibodies were confirmed as anti-Mur alloantibodies in the MNS system.Further improvements in the erythrocyte antigenic spectrum, especially the Mur antigen in Asian populations, are expected to ensure the safety of implementing electronic cross-matching in China.


Assuntos
Incompatibilidade de Grupos Sanguíneos/epidemiologia , Tipagem e Reações Cruzadas Sanguíneas/efeitos adversos , Isoanticorpos/análise , Sistema do Grupo Sanguíneo ABO/imunologia , Doadores de Sangue , Tipagem e Reações Cruzadas Sanguíneas/métodos , China/epidemiologia , Feminino , Humanos , Estudos Prospectivos , Sistema do Grupo Sanguíneo Rh-Hr/imunologia
16.
Zhongguo Gu Shang ; 32(7): 614-619, 2019 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-31382718

RESUMO

OBJECTIVE: To evaluate the effect of different bone cement injection methods during percutaneous vertebroplasty(PVP) on vertebral morphology and cement diffusion. METHODS: The clinical data of 52 patients with single-segment osteoporotic vertebral compression fracture treated from January 2016 to December 2017 were retrospectively analyzed. The patients were divided into hydraumatic group (28 cases) and pusher group (24 cases) according to bone cement injection method during PVP. By comparing visual analogue scale(VAS), height of anterior vertebral body, compression ratio, kyphosis angle before and after operation and analyzing filling ratio of bone cement in the first 1/3, median line and back 1/3 of the vertebral body in lateral X-rays and the conditions of bone cement diffusion in AP X-rays were to evaluate the effect of different bone cement injection methods on vertebral morphology and cement diffusion. RESULTS: Postoperative VAS was obviously improved in all patients and hydraumatic group was better than pusher group(P<0.05). Postoperative height of anterior vertebral body, compression ratio and kyphosis angle obviously restored in all patients while there was no significant difference between two groups(P>0.05). There was no significant difference in filling ratio of bone cement in the first 1/3 and median line of the vertebral body by lateral X-ray films between two groups(P>0.05), but in the back 1/3 of the vertebral body filling ratio of bone cement in hydraumatic group was better than in pusher group(P<0.05). The distribution of bone cement from AP X-ray films were more significant in hydraumatic group(P<0.05). CONCLUSIONS: Hydraulic delivery vertebroplasty (HDVP) has better clinical efficacy and it can guarantee sufficient distribution of bone cement into the fractured vertebra and preferably restore the morphology of vertebral body, which is worthy of clinical application.


Assuntos
Fraturas por Compressão , Fraturas por Osteoporose , Fraturas da Coluna Vertebral , Vertebroplastia , Cimentos para Ossos , Humanos , Estudos Retrospectivos , Resultado do Tratamento
18.
Tissue Eng Part C Methods ; 25(9): 523-531, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31418322

RESUMO

IMPACT STATEMENT: Noninvasive imaging techniques provide insight into physiology that is complementary to tissue morphology obtained by invasive histology. Optical imaging techniques, such as laser speckle contrast analysis, are used in vivo to longitudinally evaluate vascularization. Despite their high spatial resolution, these techniques have a limited imaging depth. In this study, we demonstrate how a dual LED-based photoacoustic (PA) and ultrasound system can delineate changes in perfusion at depth within scaffolds containing basic fibroblast growth factor. Perfusion changes detected by PA corroborated with vessel density. PA imaging could be a noninvasive and sensitive method for evaluating vascularization at depth in larger constructs.

19.
Sensors (Basel) ; 19(13)2019 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-31269769

RESUMO

Fused silica cylindrical resonant gyroscope (CRG) is a novel high-precision solid-wave gyroscope, whose performance is primarily determined by the cylindrical resonator's frequency split and quality factor (Q factor). The laser Doppler vibrometer (LDV) is extensively used to measure the dynamic behavior of fused silica cylindrical resonators. An electrical method was proposed to characterize the dynamic behavior of the cylindrical resonator to enhance the measurement efficiency and decrease the equipment cost. With the data acquisition system and the designed signal analysis program based on LabVIEW software, the dynamic behavior of the fused silica cylindrical resonator can be analyzed automatically and quickly. We compared all the electrical measurement results with the optical detection by LDV, demonstrating that the fast Fourier transform (FFT) result of the resonant frequency measured by the electrical method was 0.12 Hz higher than that with the optical method. Thus, the frequency split measured by the electrical and optical methods was the same in 0.18 Hz, and the measurement of the Q factor was basically the same in 730,000. We conducted all measurements under the same operation condition, and the optical method was used as a reference, demonstrating that the electrical method could characterize the dynamic behavior of the fused silica cylindrical resonator and enhance the measurement efficiency.

20.
Taiwan J Obstet Gynecol ; 58(4): 447-453, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31307731

RESUMO

Polycystic ovary syndrome (PCOS) is widely accepted as the most common endocrine abnormality in women of childbearing age and may be accompanied by dyslipidemia, hyperandrogenism, hyperinsulinemia, oxidative stress and infertility. Dyslipidemia is now known to play an important role in the development of PCOS. Lipid abnormalities, including elevated low-density lipoprotein and triglyceride levels and reduced high-density lipoprotein levels, are often found in women with PCOS and play an important role in PCOS; therefore, we summarize the effect of lipid abnormalities on hyperandrogenism, insulin resistance, oxidative stress and infertility in PCOS and review the effects of common lipid-lowering drugs on patients with PCOS. The purpose of this article is to elucidate the mechanisms of lipid metabolism abnormalities in the development of PCOS.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA