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1.
J Hazard Mater ; 461: 132673, 2024 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-37793261

RESUMO

Steroids have been attracting global attention given potential carcinogenic and endocrine-disrupting effects, yet the environmental status of steroids, especially their metabolites, in estuarine environment remain largely unexplored. This study investigated 31 steroids and metabolites in suspended particulate matter (SPM), water phase and sediments of the Pearl River Estuary (PRE) during the dry and wet seasons to elucidate their spatiotemporal patterning, partitioning behavior, and environmental fate. The results showed that natural steroids predominated in SPM and sediments while the metabolites predominated in water. The spatial distribution of steroids and metabolites varied seasonally, with hydrophobicity and environmental factors influencing phase partitioning in the estuary. Furthermore, a natural steroid, progesterone (P) could serve as a trustworthy chemical indicator to estimate the concentrations of steroids and metabolites in the PRE. Importantly, the mass budget of P was estimated using an improved multi-box mass balance model, revealing that outflow to the South China Sea was the primary sink of P in water (∼87%) and degradation was the primary sink of P in sediments (∼68%) of the PRE. Overall, this study offers insightful information about the distribution and environmental fate of steroids and metabolites in estuarine environment, with implications for future management strategies.


Assuntos
Sedimentos Geológicos , Poluentes Químicos da Água , Multimídia , Esteroides , Material Particulado/análise , Rios , Água , China , Monitoramento Ambiental/métodos , Poluentes Químicos da Água/análise
2.
Spectrochim Acta A Mol Biomol Spectrosc ; 304: 123375, 2024 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-37703789

RESUMO

Using sliver nanoparticles modified with ß-cyclodextrin and α-iron oxide (ß-CD/α-Fe2O3@AgNPs) as surface-enhanced Raman spectroscopy (SERS) substrate, two sensitive methods for detecting apramycin and kanamycin were established. The synthesized ß-CD/α-Fe2O3@AgNPs were characterized through ultraviolet visible (UV-vis) spectroscopy, transmission electron microscope (TEM), X-ray diffraction (XRD) and thermogravimetric analyses (TGA). The interactions of the two drugs and substrate were researched by UV-vis absorption and fourier transform infrared (FT-IR). The linear relationship between apramycin/kanamycin and SERS intensity was observed. The limits of detection (LODs) (S/N = 3) were 3.42 and 0.31 nmol/L. The two SERS methods were effectively applied to detect apramycin and kanamycin in beef samples and commercial injection. The recoveries were 96.84 - 102.20% with relative standard deviations (RSD) of 0.6---4.0% for apramycin and 95.67 - 103.18% with RSD of 1.4 - 2.5% for kanamycin, respectively.

3.
Sci Total Environ ; 907: 167982, 2024 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-37866610

RESUMO

Biomass-fired industrial boilers (BFIBs) are one of the neglected and important anthropogenic sources of air pollutants. A comprehensive boiler-based emission inventory of multiple air pollutants from BFIBs in China in 2020 was first developed based on the activity level database and updated emission factors. Results showed that national emissions of air pollutants from BFIBs in 2020 were estimated to be 11.5 kt of PM, 10.8 kt of PM10, 7.4 kt of PM2.5, 40.5 kt of SO2, 79.8 kt of NOx, 4.2 kt of organic carbon (OC), 1.0 kt of elemental carbon (EC), 31.7 kt of nonmethane volatile organic compounds (NMVOCs), 15.9 kt of NH3, and 116.5 t of five trace metals (Hg, Cr, Cd, Pb, and As), respectively. Air pollutant emissions exhibited significant spatio-temporal heterogeneity. Monthly air pollutant emissions varied by geographical division due to the combined effects of industrial production and winter heating demand. These emissions were mainly concentrated in the eastern coastal region, with Guangdong, Guangxi, Fujian, Jiangsu, and Zhejiang being the five provinces having the highest emissions. In addition, scenario predictions indicate that as the pollution and carbon reduction strategy is implemented, air pollutant emissions from BFIBs in China could become well controlled, with PM, NOx, SO2, and Hg emissions in 2050 projected to be 3.0-8.3 kt, 36.5-75.7 kt, 16.2-32.8 kt, and 0.52-0.87 t, respectively. Our results can provide a highly spatio-temporal resolution inventory of multiple air pollutant emissions from BFIBs for air quality modelling and support the formulation of air pollution control policies for biomass fuel utilization in the context of the pollution and carbon reduction strategy.

4.
Carbohydr Polym ; 325: 121570, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38008476

RESUMO

Cellulose, an abundant and eco-friendly polymer, is a promising raw material to be used for preparing energy storage devices such as lithium-ion batteries (LIBs). Despite the significance of cellulose functional groups in LIBs components, their structure-properties-application relationship remains largely unexplored. This article thoroughly reviews the current research status on cellulose-based materials for LIBs components, with a specific focus on the impact of functional groups in cellulose-based separators. The emphasis is on how these functional groups can enhance the mechanical, thermal, and electrical properties of the separators, potentially replacing conventional non-renewal material-derived components. Through a meticulous investigation, the present review reveals that certain functional groups, such as hydroxyl groups (-OH), carboxyl groups (-COOH), carbonyl groups (-CHO), ester functions (R-COO-R'), play a crucial role in improving the mechanical strength and wetting ability of cellulose-based separators. Additionally, the inclusion of phosphoric group (-PO3H2), sulfonic group (-SO3H) in separators can contribute to the enhanced thermal stability. The significance of comprehending the influence of functional groups in cellulose-based materials on LIBs performance is highlighted by these findings. Ultimately, this review explores the challenges and perspectives of cellulose-based LIBs, offering specific recommendations and prospects for future research in this area.

6.
J Mater Chem B ; 2023 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-38047895

RESUMO

Non-invasive cancer therapies, especially those based on reactive oxygen species, including photodynamic therapy (PDT), have gained much interest. As emerging photodynamic nanocarriers, metal-organic frameworks (MOFs) based on porphyrin can release reactive oxygen species (ROS) to destroy cancer cells. However, due to the inefficient production of ROS by photosensitizers and the over-expression of glutathione (GSH) in the tumor microenvironment (TME), their therapeutic effect is not satisfactory. Therefore, herein, we developed a multi-functional nanoparticle, HN@Cu-MOF, to enhance the efficacy of PDT. We combined chemical dynamic therapy (CDT) and nitric oxide (NO) therapy by initiating sensitization to PDT and cell apoptosis in the treatment of tumors. The Cu2+-doped MOF reacted with GSH to form Cu+, exhibiting a strong CDT ability to generate hydroxyl radicals (˙OH). The Cu-MOF was coated with HN, which is hyaluronic acid (HA) modified by a nitric oxide donor. HN can target tumor cells over-expressing the CD44 receptor and consume GSH in the cells to release NO. Both cell experiments and in vivo experiments showed an excellent tumor inhibitory effect upon the treatment. Overall, the HN@Cu-MOF nanoparticle-integrated NO gas therapy and CDT with PDT led to a significant enhancement in GSH consumption and a remarkable elevation in ROS production.

7.
PLoS One ; 18(12): e0295313, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38039276

RESUMO

The sustainable development of the sports industry has garnered extensive attention worldwide. In this study, after a rigorous explanation of the connotation of the sports industry development resilience coefficient (SIDRC), the Topsis model and exploratory spatial data analysis were comprehensively employed to evaluate and visualize the SIDRC of 285 cities in China. Additionally, a spatial econometric model was constructed to explore the influencing factors of SIDRC. The major conclusions drawn from this study are as follow: (1) While the SIDRC has improved significantly over the study period, it still remains overall at a low level of resilience with a widening gap between cities. (2) A strong spatial imbalance exists in the distribution of SIDRC, with coastal regions demonstrating greater resilience compared to the central and western regions, and provincial capital cities faring better than other cities. (3) Policy support index, economic development level, structural diversity of the sports industry, and social participation play crucial roles in promoting SIDRC. Finally, social participation has a positive impact on SIDRC in neighboring cities by facilitating resource sharing, market expansion, and extending the industrial chain. The paper concludes by offering recommendations such as increasing the construction of sports markets and public participation, which can optimize the layout of the sports industry and enhance industrial development resilience.


Assuntos
Desenvolvimento Industrial , Indústrias , Cidades , China , Desenvolvimento Econômico
8.
Cell ; 186(23): 4996-5014.e24, 2023 11 09.
Artigo em Inglês | MEDLINE | ID: mdl-37949056

RESUMO

A formal demonstration that mammalian pluripotent stem cells possess preimplantation embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early embryo complementation with homologous cells. Whereas such naive pluripotency has been well demonstrated in rodents, poor chimerism has been achieved in other species including non-human primates due to the inability of the donor cells to match the developmental state of the host embryos. Here, we have systematically tested various culture conditions for establishing monkey naive embryonic stem cells and optimized the procedures for chimeric embryo culture. This approach generated an aborted fetus and a live chimeric monkey with high donor cell contribution. A stringent characterization pipeline demonstrated that donor cells efficiently (up to 90%) incorporated into various tissues (including the gonads and placenta) of the chimeric monkeys. Our results have major implications for the study of primate naive pluripotency and genetic engineering of non-human primates.


Assuntos
Células-Tronco Embrionárias , Engenharia Genética , Haplorrinos , Animais , Feminino , Gravidez , Haplorrinos/genética , Nascido Vivo , Mamíferos , Células-Tronco Pluripotentes , Primatas , Engenharia Genética/métodos
9.
Artigo em Inglês | MEDLINE | ID: mdl-37988286

RESUMO

Conductive atomic force microscopy (CAFM) has become the preferred tool of many companies and academics to analyze the electronic properties of materials and devices at the nanoscale. This technique scans the surface of a sample using an ultrasharp conductive nanoprobe so that the contact area between them is very small (<100 nm2) and it can measure the properties of the sample with a very high lateral resolution. However, measuring relatively low currents (∼1 nA) in such small areas produces high current densities (∼1000 A/cm2), which almost always results in fast nanoprobe degradation. That is not only expensive but also endangers the reliability of the data collected because detecting which data sets are affected by tip degradation can be complex. Here, we show an inexpensive long-sought solution for this problem by using a current limitation system. We test its performance by measuring the tunneling current across a reference ultrathin dielectric when applying ramped voltage stresses at hundreds of randomly selected locations of its surface, and we conclude that the use of a current limitation system increases the lifetime of the tips by a factor of ∼50. Our work contributes to significantly enhance the reliability of one of the most important characterization techniques in the field of nanoelectronics.

10.
J Hazard Mater ; 465: 133088, 2023 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-38016320

RESUMO

The substantial utilization of antibiotics causes their "pseudo-persistence" in offshore environments. Published studies on antibiotic surveillance in food webs have primarily emphasized on parent forms; however, the compositions and concentrations of conjugated antibiotics in aquatic organisms remain largely unexplored. This study systematically examined the distribution characteristics and trophodynamics of free antibiotics and their conjugated forms in an estuarine food web. Total antibiotic levels differed insignificantly between the surface and bottom waters. The total mean values of free antibiotics in crabs, fish, shrimps, sea cucumbers, and snails varied from 0.77 to 1.4 ng/g (wet weight). The numbers and values of antibiotics rose in these biological samples after enzymatic hydrolysis. Conjugated antibiotics accounted for 23.8-76.9% of the total antibiotics in the biological samples, revealing that conjugated forms play a non-negligible role in aquatic organisms. More number of antibiotics exhibited bioaccumulation capabilities after enzymatic hydrolysis. In the food web, the free forms of anhydroerythromycin and conjugated forms of trimethoprim and ciprofloxacin underwent trophic dilution, whereas the free forms of trimethoprim and conjugated forms of ofloxacin underwent trophic amplification. The present work provides new insights into the bioaccumulation and trophic transfer of free and conjugated antibiotics in food webs.

11.
J Neurol ; 2023 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-38036920

RESUMO

BACKGROUND: Stroke is a significant medical condition, and blood pressure stands out as the most prevalent treatable risk factor associated with it. Researches link blood pressure variability (BPV) with stroke; however, the specific relationship between with the outcomes of stroke patients remains unclear. As blood pressure variability and mean blood pressure are interrelated, it remains uncertain whether BPV adds additional information to understanding the outcome of acute stroke patients. OBJECTIVE: To systematically review studies investigating the association between blood pressure variability and prognosis in acute stroke patients. METHODS: Embase, PubMed, Web of Science, and the Cochrane Library were searched for English language full-text articles from the inception to 1 January 2023. Stroke patients aged ≥ 18 years were included in this analysis. Stroke types were not restricted. RESULTS: This meta-analysis shows that higher systolic blood pressure variability is linked to a higher risk of poor outcome, including function disability, mortality, early neurological deterioration, and stroke recurrence, among acute stroke patients without thrombolysis. A higher diastolic blood pressure variability is linked with to a higher risk of mortality and functional disability. CONCLUSIONS: This review reveals that blood pressure variability is a novel and clinically relevant risk factor for stroke patients' outcome. Future studies should investigate how best to measure and define BPV in acute stroke. Larger studies are warranted to provide more robust evidence in this area.

12.
Br J Soc Psychol ; 2023 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-37933472

RESUMO

People in many societies report that they do not have enough time. What makes people feel so rushed? We propose that economic inequality leads to perceived time poverty by increasing status anxiety. Five studies examined this line of reasoning. Study 1 (N = 230) found a positive correlation between economic inequality and perceived time poverty. Study 2 (N = 194) manipulated economic inequality to test the causal link between economic inequality and perceived time poverty. The results showed that people perceived more time poverty in the high (vs. low) economic inequality condition. Study 3 (N = 381) supported the mediating role of status anxiety in the relationship between economic inequality and perceived time poverty using a questionnaire survey. Study 4 (pre-registered; N = 283) manipulated economic inequality in an ecological valid way and yielded further support for the hypotheses. In pre-registered Study 5 (N = 233), a blockage manipulation design was employed to test the mediating effect of status anxiety as a function of economic inequality, which provided causal evidence for the proposed mediator. Our findings suggest that economic inequality serves as a structural societal factor that fuels people's perception of time poverty.

13.
BMC Pediatr ; 23(1): 546, 2023 10 31.
Artigo em Inglês | MEDLINE | ID: mdl-37907926

RESUMO

BACKGROUND: To investigate the clinical manifestations, prognosis, and possibly related genes of anomalous right coronary artery originating from the aorta (ARCA-L) in children. METHODS: This case series study included pediatric patients diagnosed with ARCA-L at the Department of Cardiology in Beijing Children's Hospital affiliated to Capital Medical University, between January 2017 and December 2019. RESULTS: Nine pediatric patients (aged 3 months to 12 years, 4 boys) were included. Two cases presented with cardiac insufficiency as their primary manifestation, while the remaining seven had post-infection or post-exercise symptoms such as chest pain, chest tightness, long exhalation, lack of strength, and dizziness. Six patients displayed varying degrees of ST-T changes on the electrocardiograph, while two patients had a reduced left ventricular ejection fraction (LVEF) of 20-32% according to echocardiography. Multislice computed tomographic angiography confirmed the presence of ARCA-L in all patients. One patient underwent the unroofing technique. The remaining eight received conservative treatment. After a follow-up of 2-64 months, eight children had a good prognosis and survived. One child experienced sudden death due to aggravated heart failure. Whole exome sequencing revealed that one child tested negative, one had mutations in the RYR2 and LDB3 genes, and the remaining four patients had a mutation in the GDF1, LRP6, MEF2A, and KALRN genes, respectively. CONCLUSIONS: ARCA-L in children might have a wide variation in clinical manifestations and a risk of sudden death. The occurrence of the disease might be associated with genetic defects.


Assuntos
Anomalias dos Vasos Coronários , Insuficiência Cardíaca , Masculino , Criança , Humanos , Volume Sistólico , Anomalias dos Vasos Coronários/diagnóstico por imagem , Função Ventricular Esquerda , Aorta , Estudos Retrospectivos , Morte Súbita
14.
Cureus ; 15(10): e46603, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37937018

RESUMO

PURPOSES: The primary aim of this clinical study is to identify the factors associated with rapid glycemic, bodyweight, and lipid profile remission in young obese patients following bariatric surgery. MATERIALS AND METHODS: In a total of 131 Chinese in-patients at Shanghai Pudong Hospital, China, we retrospectively analyzed in-patient data of metabolic parameters, including BMI, waist circumference, blood pressure (BP), and blood laboratory tests, such as plasma lipids and lipoprotein, hemoglobulin A1c (HbA1c), and oral glucose tolerance tests (OGTT) before bariatric surgery. We followed up these indices at the first month, third months, half-year, and one year later. RESULTS: The results showed that bodyweight, BP, fasting plasma glucose (FPG), HbA1c, and triglyceride (TG) levels decreased significantly in one to three months following surgery in both male and female patients (p<0.05). We demonstrated that age (male: ß=-0.181; female: ß=-0.292) and the pre-operation HbA1c levels (male: ß=0.935; female: ß=0.919) were independent predictors of HbA1c reduction in both young obese male and female patients in three months after surgery. For body weight loss, age (ß=-0.229) and pre-operation bodyweight (ß=0.735) are the predictors in females, but only pre-operation body weight (ß=0.798) is the independent predictor in obese young male patients. CONCLUSION:  This study discovered that changes in bodyweight were determined by age, pre-operation status of bodyweight, and HbA1C in obese young Chinese.

15.
Int J Biol Macromol ; 255: 127988, 2023 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-37956809

RESUMO

In this study, we constructed a novel powder-laden core-shell crosslinked chitosan microneedle patch for high-dose and controllable delivery of various drugs, including both macromolecular biological drugs and small-molecule chemical drugs. Direct loading of drug powders greatly improved drug loading capacity and minimized degradation. The results of the in vitro drug release study suggested that the release behaviors of the most tested drugs (both macromolecular drugs and small-molecule drugs) can be tuned by adjusting the crosslink density of the microneedle shell to achieve either rapid or sustained release of the loaded drug. The in vivo hypoglycemic efficacy test in streptozotocin-induced diabetic mice further proved that the onset and duration of the insulin-laden patch can be customized by adjusting the crosslink density. Furthermore, a combination of microneedle patches with different crosslink densities not only rapidly reduced blood glucose levels to normoglycemic levels (within 1 h) but also maintained normoglycemia for up to 36 h. The insulin loaded in the patch also showed good stability during storage at 40 °C for 6 months. Our results suggest that this powder-laden patch represents a strong candidate for addressing the multiple challenges in the preparation and application of polymeric microneedles and shows promise in clinical applications.

16.
medRxiv ; 2023 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-37961588

RESUMO

Background: Cognitive impairment in older adults poses considerable challenges, and the role of family support becomes increasingly crucial. This study aims to examine the impact of children's residential proximity and spousal presence on the key modifiable risk factors for dementia among older adults with cognitive impairment. Methods: Utilizing the Health and Retirement Study (HRS) data from 1995 to 2018, we analyzed 14,731 participants (35,840 person-waves) aged 50 and older with cognitive impairment. Family support was characterized based on the presence of a spouse and residential proximity to children. Smoking, depressive symptoms and social isolation were included as the key modifiable risk factors for dementia identified in later life. Using mixed-effects logistic regressions, associations between access to family support and the modifiable risk factors were determined, adjusting for various socio-demographic and health-related factors. Results: Significant associations were found between access to family support and modifiable risk factors for dementia. Cognitively impaired older adults with less available family support, characterized by distant-residing children and the absence of a spouse, had significantly higher risks of smoking, depressive symptoms, and social isolation. Moreover, we revealed a consistent gradient in the prevalence of the risk factors based on the degree of family support. Relative to older adults with a spouse and co-resident children, those without a spouse and with all children residing further than 10 miles displayed the highest risks of smoking, depressive symptoms, and social isolation. Conclusion: Access to family support, particularly from spouses and proximate children, plays a protective role against key modifiable risk factors for dementia in older adults with cognitive impairment. The findings highlight the need for bolstering family and social support systems to enhance the well-being of this vulnerable population.

17.
ACS Appl Electron Mater ; 5(9): 5025-5031, 2023 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-37779889

RESUMO

Resistive random access memories (RRAM), based on the formation and rupture of conductive nanoscale filaments, have attracted increased attention for application in neuromorphic and in-memory computing. However, this technology is, in part, limited by its variability, which originates from the stochastic formation and extreme heating of its nanoscale filaments. In this study, we used scanning thermal microscopy (SThM) to assess the effect of filament-induced heat spreading on the surface of metal oxide RRAMs with different device designs. We evaluate the variability of TiO2 RRAM devices with area sizes of 2 × 2 and 5 × 5 µm2. Electrical characterization shows that the variability indicated by the standard deviation of the forming voltage is ∼2 times larger for 5 × 5 µm2 devices than for the 2 × 2 µm2 ones. Further knowledge on the reason for this variability is gained through the SThM thermal maps. These maps show that for 2 × 2 µm2 devices the formation of one filament, i.e., hot spot at the device surface, happens reliably at the same location, while the filament location varies for the 5 × 5 µm2 devices. The thermal information, combined with the electrical, interfacial, and geometric characteristics of the device, provides additional insights into the operation and variability of RRAMs. This work suggests thermal engineering and characterization routes to optimize the efficiency and reliability of these devices.

18.
Diabetes Metab Syndr Obes ; 16: 3197-3211, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37867628

RESUMO

Backgrounds and Objective: Diabetic foot is a relatively severe complication in patients with type 2 diabetes (T2D), with peripheral neuropathy and angiopathy frequently serving as risk factors. However, it is unknown how the other major systemic metabolic factors impacted the profile of these patients, besides glucose management. Thus, we investigated the distinct characteristics of patients with diabetic foot ulcers and their relationships with angiopathy. Materials and Methods: We obtained the laboratory data of 334 diabetic patients at Shanghai Pudong Hospital from 2020 to 2023. The comparisons were performed between the groups with or without diabetic foot, including glucose metabolism, lipids profile, liver and kidney function, thyroid function, and serum iron. The association between metabolic factors and lower extremity computed tomography angiography (CTA) was analyzed. Results: We found significant disparities between groups in relation to age, serum protein content, liver transferase, serum creatinine, estimated glomerular filtration rate (eGFR), serum uric acid (UA), small dense low-density lipoprotein (sdLDL), lipoprotein A (LP(a)), apolipoprotein A1 (APOA1), thyroid function, serum iron, and hemoglobin (Hb) (p<0.05). The Spearman correlational analyses showed that the severity of CTA, categorized by the unilateral or bilateral plaque or occlusion, was positively significantly correlated with UA (r=0.499), triglyceride (TG) (r=0.751), whereas inversely correlated with serum albumin (r=-0.510), alanine aminotransferase (r=-0.523), direct bilirubin (DBil) (r=-0.494), total bilirubin (TBil) (r=-0.550), Hb (r=-0.646). Conclusion: This cross-section investigation showed that compared to T2D only, the patients with diabetic foot ulcer (DFU) might display similar glucose metabolic control context but adverse metabolic profiles, and this profile is associated with macrovascular angiopathy characteristics and their severity.

19.
Front Pharmacol ; 14: 1253572, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37849730

RESUMO

Background: Diabetic cardiomyopathy (DCM) is a severe complication of diabetes that can diminish the quality of life in patients and is a leading cause of death. Research has demonstrated the effectiveness of Traditional Chinese Medicine (TCM) in reducing blood sugar levels and protecting cardiovascular function in both animal models and clinical research studies. Nevertheless, the efficacy of TCM in animal models of DCM has not been analyzed systematically. Method: We searched the following electronic bibliographic databases: Web of Science, PubMed, Cochrane Library, and CNKI(China National Knowledge Infrastructure). Studies that reported the efficacy of TCM in animals with DCM were included. The literature search was conducted using the terms. The data will be restricted from the year 2013 to 24 April 2023, 24 studies were included in the meta-analysis. Result: A total of 24 Traditional Chinese Medicine interventions and 2157 animals met the inclusion criteria. The pooled data revealed that TCM interventions resulted in significant improvements in body weight (BW), heart weight (HW) to body weight ratio (HW/BW), triglyceride (TG) and cholesterol (TC) levels, ejection fraction (EF), fractional shortening (FS) and E/A ratio. Subgroup analysis and meta-regression revealed that the type of TCM, duration of intervention, method of modeling, and animal species were potential sources of heterogeneity. Conclusion: TCM interventions were associated with significant improvements in body weight, heart weight to body weight ratio, triglyceride and cholesterol levels, left ventricular internal dimension in systole, ejection fraction, fractional shortening and E/A ratio. The heterogeneity in the results was found to be potentially due to the type of TCM, duration of intervention, method of modeling, and animal species, as shown in subgroup analysis and meta-regression. Systematic Review Registration: identifier CRD42023402908.

20.
Front Endocrinol (Lausanne) ; 14: 1224858, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37795363

RESUMO

Polycystic ovary syndrome (PCOS) is a common endocrinopathy causing infertility in childbearing women. Progestin-primed ovarian stimulation (PPOS) protocol has recently been used for infertile women. However, whether PPOS provides a significant benefit over gonadotropin-releasing hormone (GnRH) analogue protocols in PCOS is still controversial. The objective of this systematic review is to investigate the efficacy of PPOS in patients with PCOS during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). We searched Medline, Embase, Google Scholar, ClinicalTrials, and Cochrane Central Register of Controlled Trials from inception to April 1, 2023. Randomized controlled trials (RCTs) and observational studies comparing the efficacy between PPOS and conventional GnRH analogue protocols in patients with PCOS in English were included. The primary outcomes included live birth rate, the incidence of moderate or severe ovarian hyperstimulation syndrome (OHSS), and the number of metaphase II oocytes. The pooled estimates were calculated using the random-effects models as odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CIs). Three RCTs and six cohort studies involving 2289 patients were included. Results from RCTs suggest that PPOS leads to no significant difference in the risk of OHSS, the number of metaphase II oocytes, or the rate of live birth when compared to GnRH analogue protocols. The pooling estimates of cohort studies showed consistent results. Additionally, in cohort studies, PPOS required a higher dose of Gn and tended to improve the implantation rate, clinical pregnancy rate, and ongoing pregnancy rate. For subgroup analyses, the higher implantation rate, clinical pregnancy rate, and ongoing pregnancy rate were found in PPOS compared to the GnRH agonist short protocol. However, the certainty of the evidence for the outcomes was generally low. Overall, There is currently no evidence to support that PPOS could reduce the risk of OHSS, increase oocyte maturation, or improve pregnancy outcomes in women with PCOS undergoing IVF/ICSI when compared to GnRH analogue protocols. Considering its efficiency and safety, this protocol could be a patient-friendly and viable alternative for PCOS patients, especially when frozen-thawed embryo transfer is planned. Future high-quality randomized trials with children's long-term safety and cost-effective analyses are still required. System Review Registration: NPLASY (202340059). https://inplasy.com/inplasy-2023-4-0059/.


Assuntos
Síndrome de Hiperestimulação Ovariana , Síndrome do Ovário Policístico , Feminino , Humanos , Gravidez , Fertilização In Vitro/métodos , Hormônio Liberador de Gonadotropina , Síndrome de Hiperestimulação Ovariana/epidemiologia , Indução da Ovulação/métodos , Síndrome do Ovário Policístico/complicações , Síndrome do Ovário Policístico/terapia , Progestinas/uso terapêutico , Esteroides
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