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1.
Food Chem ; 398: 133875, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35964573

RESUMO

The effects of radio frequency (RF) heating on horseradish peroxidase (HRP) activity and its structure were investigated in this paper. The HRP was heated to 50 °C, 70 °C and 90 °C at different electrode gaps (100, 110 and 120 mm). The relative enzyme activity was 105.33 %-113.73 % at 50 °C, 91.11 %-93.05 % at 70 °C and 47.05 %-68.17 % at 90 °C. Ultraviolet-visible, circular dichroism and fluorescence spectra were used to monitor the variation in secondary and tertiary structure. The results showed that RF heating at the electrode gaps of 120 mm contributed to more severe enzyme inactivation and conformational destruction, which can be explained by the changes in Soret band, secondary structure content and tryptophan fluorescence intensity. This study revealed that enzyme inactivation by RF heating was associated with loss of helical structure, unfolding of enzyme protein and ejection of heme group.


Assuntos
Calefação , Ondas de Rádio , Dicroísmo Circular , Peroxidase do Rábano Silvestre/metabolismo , Estrutura Secundária de Proteína
2.
Bioact Mater ; 19: 690-702, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35600978

RESUMO

Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can efficiently inhibit OS metastasis. Bioactive nanoparticles such as zinc oxide nanoparticles (ZnO NPs) can efficiently inhibit OS growth, however, the effect and mechanisms of them on tumor metastasis are still not clear. In this study, we firstly prepared well-dispersed ZnO NPs and proved that ZnO NPs can inhibit OS metastasis-related malignant behaviors including migration, invasion, and epithelial-mesenchymal transition (EMT). RNA-Seqs found that differentially expressed genes (DEGs) in ZnO NP-treated OS cells were enriched in wingless/integrated (Wnt) and hypoxia-inducible factor-1 (HIF-1) signaling pathway. We further proved that Zn2+ released from ZnO NPs induced downregulation of ß-catenin expression via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway. ZnO NPs combined with ICG-001, a ß-catenin inhibitor, showed a synergistic inhibitory effect on OS lung metastasis and a longer survival time. In addition, tissue microarray (TMA) of OS patients also detected much higher ß-catenin expression which indicated the role of ß-catenin in OS development. In summary, our current study not only proved that ZnO NPs can inhibit OS metastasis by degrading ß-catenin in HIF-1α/BNIP3/LC3B-mediated mitophagy pathway, but also provided a far-reaching potential of ZnO NPs in clinical OS treatment with metastasis.

3.
Curr Eye Res ; : 1-9, 2022 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-36066502

RESUMO

PURPOSE: To evaluate the relationship between ocular magnification correction and macular choroidal thickness (ChT) measurements in children, and to demonstrate when ocular magnification correction is necessary. METHODS: Chinese children aged 6-9 years with various refractive statuses were included. Swept-source optical coherence tomography was used to measure macular ChT. A self-designed program was adopted to simulate ChT changes in each sector of the ETDRS grid in the macula under various simulated axial lengths (ALs). RESULTS: ChT measurements were not affected for all simulated ALs in over 95% of the individuals in the central fovea. In the inferior, superior, and temporal parafoveal sectors, the extent of AL that may include 95% of the individuals narrowed from approximately 22.0 mm to 27.2 mm. In the nasal parafoveal sector and inferior, superior, and temporal perifoveal sectors, the extent of AL that may include 95% of the individuals became even narrower, from approximately 22.8 mm to 26.0 mm. The narrowest extent was observed in the perifoveal nasal sector, ranging from 23.3 mm to 25.5 mm. The effect of ocular magnification was more significant in hyperopes than in myopes in the inferior parafoveal sector and temporal, superior, and nasal perifoveal sectors. CONCLUSION: During macular ChT measurements, ocular magnification correction is not necessary in the central fovea. However, ocular magnification should be corrected normally in the nasal perifoveal region and in individuals with ALs shorter than 22.8 mm or longer than 26.0 mm in the remaining macular regions.

4.
Pathol Oncol Res ; 28: 1610401, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36061145

RESUMO

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-mediated senescence-associated secretory phenotype (SASP) pathway has recently been identified in the suppression and promotion of cancers. However, its practical role in carcinogenesis remains to be comprehensively elucidated. Here, we describe an investigation analysing SASP activity and its correlations with DNA damage response (DDR), genomic mutations, and cell proliferation in gastric carcinogenesis among 30 cases with available endoscopic submucosal dissection (ESD) specimens of early neoplastic lesions (including low-grade dysplasia [LGD], high-grade dysplasia [HGD], and intramucosal carcinoma). The positive cells of senescence-associated ß-galactosidase staining and cGAS, STING, interferon-regulatory factor 3 (IRF3), and signal transducer and activator of transcription 6 (STAT6) expression levels using immunostaining were elevated in HGD and in cancers. Similarly, increased expression of the Fanconi anemia group D2 (FANCD2) protein, tumour suppressor p53 binding protein 1 (TP53BP1), and replication protein A (RPA2) (i.e., primary DDR factors) was detected in HGD and in cancers; these increased expression levels were closely correlated with high expression of Ki67 and minichromosome maintenance complex component 7 (MCM7) proteins. Moreover, genomic mutations in TP53 gene were detected in 56.67% of the evaluated cases (17/30) using next-generation sequencing, and positive staining was verified in HGD and in cancers. Statistical analysis revealed that cell proliferation closely correlated with the expression of DDR factors, of which TP53BP1 was positively associated with SASP factors and IRF3 was positively correlated with cell proliferation. In addition, an analysis evaluating clinical features demonstrated that STAT6-positive cases showed a longer progression-free survival time than STAT6-negative cases. Our evaluation, conducted using a limited number of specimens, suggests SASP may be prevalent in early gastric neoplastic lesions and could be activated by accelerated cell proliferation-induced DDR. The clinical significance of SASP still needs to be determined.


Assuntos
Senescência Celular , Neoplasias , Carcinogênese , Proliferação de Células/genética , Senescência Celular/genética , Dano ao DNA/genética , Humanos , Proteínas de Membrana , Nucleotidiltransferases/genética , Nucleotidiltransferases/metabolismo
5.
BMC Infect Dis ; 22(1): 723, 2022 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-36064333

RESUMO

BACKGROUND: The prevalence of infectious diseases remains one of the major challenges faced by the Chinese health sector. Policymakers have a tremendous interest in investigating the spatiotemporal epidemiology of infectious diseases. We aimed to review the small-scale (city level, county level, or below) spatiotemporal epidemiology of notifiable infectious diseases in China through a systematic review, thus summarizing the evidence to facilitate more effective prevention and control of the diseases. METHODS: We searched four English language databases (PubMed, EMBASE, Cochrane Library, and Web of Science) and three Chinese databases (CNKI, WanFang, and SinoMed), for studies published between January 1, 2004 (the year in which China's Internet-based disease reporting system was established) and December 31, 2021. Eligible works were small-scale spatial or spatiotemporal studies focusing on at least one notifiable infectious disease, with the entire territory of mainland China as the study area. Two independent reviewers completed the review process based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. RESULTS: A total of 18,195 articles were identified, with 71 eligible for inclusion, focusing on 22 diseases. Thirty-one studies (43.66%) were analyzed using city-level data, 34 (47.89%) were analyzed using county-level data, and six (8.45%) used community or individual data. Approximately four-fifths (80.28%) of the studies visualized incidence using rate maps. Of these, 76.06% employed various spatial clustering methods to explore the spatial variations in the burden, with Moran's I statistic being the most common. Of the studies, 40.85% explored risk factors, in which the geographically weighted regression model was the most commonly used method. Climate, socioeconomic factors, and population density were the three most considered factors. CONCLUSIONS: Small-scale spatiotemporal epidemiology has been applied in studies on notifiable infectious diseases in China, involving spatiotemporal distribution and risk factors. Health authorities should improve prevention strategies and clarify the direction of future work in the field of infectious disease research in China.


Assuntos
Doenças Transmissíveis , China/epidemiologia , Doenças Transmissíveis/epidemiologia , Humanos , Incidência , Prevalência , Fatores de Risco
6.
Sci Rep ; 12(1): 15070, 2022 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-36064877

RESUMO

A seizure likelihood biomarker could improve seizure monitoring and facilitate adjustment of treatments based on seizure risk. Here, we tested differences in patient-specific 24-h-modulation patterns of electrodermal activity (EDA), peripheral body temperature (TEMP), and heart rate (HR) between patients with and without seizures. We enrolled patients who underwent continuous video-EEG monitoring at Boston Children's Hospital to wear a biosensor. We divided patients into two groups: those with no seizures and those with at least one seizure during the recording period. We assessed the 24-h modulation level and amplitude of EDA, TEMP, and HR. We performed machine learning including physiological and clinical variables. Subsequently, we determined classifier performance by cross-validated machine learning. Patients with seizures (n = 49) had lower EDA levels (p = 0.031), EDA amplitudes (p = 0.045), and trended toward lower HR levels (p = 0.060) compared to patients without seizures (n = 68). Averaged cross-validated classification accuracy was 69% (AUC-ROC: 0.75). Our results show the potential to monitor and forecast risk for epileptic seizures based on changes in 24-h patterns in wearable recordings in combination with clinical variables. Such biomarkers might be applicable to inform care, such as treatment or seizure injury risk during specific periods, scheduling diagnostic tests, such as admission to the epilepsy monitoring unit, and potentially other neurological and chronic conditions.


Assuntos
Eletroencefalografia , Epilepsia , Biomarcadores , Criança , Eletroencefalografia/métodos , Frequência Cardíaca , Humanos , Aprendizado de Máquina , Monitorização Fisiológica
7.
J Environ Public Health ; 2022: 5841017, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072490

RESUMO

At the current university stage, university students are subjected to a variety of pressures such as role change adaptation pressure, study and life pressure, emotional pressure, economic pressure, employment pressure, and interpersonal pressure, which seriously affect their physical and mental health. Students with poor psychological tolerance may develop psychological disorders and, in serious cases, may even lead to mental illness. The results of the study indicated that 17%-20.23% of university students have psychological disorder problems. Excessive and long-lasting stress can cause psychological, depression and anxiety, physical fatigue, and discomfort, which can lead to various diseases and even death. It is, therefore, of great importance to study the state of mental health and stress among university students as well as to develop countermeasures to improve their mental health. This study focuses on the impact of martial arts sports on the mental health of university students. As a type of sport, martial arts sports are particularly special in which they can intertwine the nurturing spirit of traditional culture with the nurturing spirit of sports. The development of martial arts sports in colleges and universities can not only enhance the physical quality of college students but also promote the development of their physical and mental health. Therefore, this article takes Taijiquan as an example to explore the study of the impact of martial arts sports health on college students' mental health.


Assuntos
Artes Marciais , Saúde Mental , Ansiedade/etiologia , Humanos , Estudantes/psicologia , Universidades
8.
Hortic Res ; 9: uhac138, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072838

RESUMO

Flavonol glycosides are health-promoting phytochemicals important for human nutrition and plant defense against environmental stresses. Glycosylation modification greatly enriches the diversity of flavonols. Morella rubra, a member of the Myricaceae, contains high amounts of myricetin 3-O-rhamnoside (M3Rha), quercetin 3-O-rhamnoside (Q3Rha), and quercetin 3-O-galactoside (Q3Gal). In the present study, MrUGT78R1 and MrUGT78R2 were identified as two functional UDP-rhamnosyltransferases, while MrUGT78W1 was identified as a UDP-galactosyltransferase. Site-directed mutagenesis identified Pro143 and Asn386 as important residues for rhamnosyl transfer activity of MrUGT78R1, while the two corresponding positions in MrUGT78W1 (i.e. Ser147 and Asn370) also play important roles in galactosyl transfer activity. Transient expression data for these three MrUGTs in Nicotiana benthamiana tested the function of MrUGT78R1 and MrUGT78R2 as rhamnosyltransferases and MrUGT78W1 as a galactosyltransferase in glycosylation of flavonols. This work enriches knowledge of the diversity of UDP-rhamnosyltransferase in planta and identifies two amino acid positions important for both rhamnosyltransferase and galactosyltransferase.

9.
Front Public Health ; 10: 980352, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36062120

RESUMO

Background: Previous studies assessed the relationship between individual sleep behavior and fracture risk, rather than taking into account the joint complexity of the sleep behaviors. We aimed to explore the association between sleep pattern and risk of imminent recurrent osteoporotic fracture in older hospitalized patients due to an index osteoporotic fracture, where sleep pattern was evaluated as a combination incorporating five common sleep behaviors (i.e., insomnia, snoring, nocturnal sleep duration, daytime napping, and midnight waking up). Methods: We used data from a prospective cohort study for analyses. Patients who aged not < 55 years and were admitted to the hospital due to an index osteoporotic fracture were recruited. Sleep pattern was grouped as healthy, intermediate, and poor pattern, based on the categorization of overall sleep scores. We used Cox proportional hazard models to explore sleep pattern in relation to imminent recurrent fracture. Results: We included a total of 185 elderly hospitalized patients for analyses with mean (± standard deviation) age = 71.5 ± 10.3 years and 87.0% female. During a mean follow-up of 14.7 months, there were 10 (5.4%) recurrent osteoporotic fractures observed. A significantly higher overall sleep score was found in patients with recurrent fractures when compared with those without fractures (3.20 vs. 2.36, p = 0.038). Both intermediate (p = 0.76) and poor sleep patterns (p = 0.093) were non-significantly associated with an elevated risk of fracture when compared with a healthy pattern. Per-one-increase in the overall sleep score was significantly related to an increased risk of fracture: hazard ratio = 1.60 (95% confidence interval: 1.00--2.55) from the multivariable model. Conclusion: Per-one-increase in the overall sleep score was found to be significantly associated with a 60% higher risk of imminent recurrent osteoporotic fracture in the elderly, and intermediate and poor sleep patterns were non-significantly related to an increased risk of recurrent fracture. More high-quality evidence is required to further evaluate the relationship between the sleep pattern and the risk of recurrent osteoporotic fracture in the elderly.


Assuntos
Fraturas por Osteoporose , Idoso , Idoso de 80 Anos ou mais , Feminino , Hospitalização , Humanos , Masculino , Pessoa de Meia-Idade , Fraturas por Osteoporose/epidemiologia , Fraturas por Osteoporose/etiologia , Modelos de Riscos Proporcionais , Estudos Prospectivos , Sono
10.
Comput Intell Neurosci ; 2022: 3493678, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36065375

RESUMO

With the rapid development of information technology, the amount of all kinds of data information is increasing rapidly. As an important means to collect, store, and manage massive data, and then analyze and predict the habits and characteristics of certain groups of people and even the development trend of a certain industry, big data technology provides a comprehensive strategic basis for management decision makers that the traditional processing mode cannot match. Contemporary management accounting serves the whole process of enterprise internal control, so it will produce a large number of various data. With the explosive growth of network data and the increasing scale of database, more and more people begin to study data mining, and the classification algorithm, as the key technology in data mining, has also received extensive attention. In order to further improve the information technology level of enterprise management accounting and increase the depth of information application, many enterprises began to pay more attention to data mining, and through deep data mining, the depth and breadth of enterprise data analysis were improved. In the research of data and accounting informatization, data mining technology accounts for about 50% of informatization, which is the way for future development. With the advent of the information age, the dependence of enterprises on information technology in the process of accounting management has been further improved. If enterprises want to achieve better development in the information age, they need to pay more attention to the information technology of management accounting and improve the application ability of enterprise staff in information.


Assuntos
Mineração de Dados , Tecnologia da Informação , Bases de Dados Factuais , Humanos
11.
Artigo em Inglês | MEDLINE | ID: mdl-36070473

RESUMO

Droplet charging is an effective method to enhance dust removal efficiency using an electrostatic spray scrubber (ESS). However, effects of the materials and dimensions of different electrodes on droplet charging efficiency have not been studied systematically. In this study, ring-shaped electrodes were selected to test effects of three electrode materials (copper, stainless steel, and graphite) with various dimensions on droplet charging efficiency. A Faraday pail charge measurement device was used to measure the droplet charge generated by the electrodes. A reduced factorial design with four factors was used in this study to investigate the charging efficiency affected by the factors. The four factors tested were electrode material, electrode diameter, nozzle height, and applied voltage. A 304L stainless steel electrode was found to achieve higher droplet charge-to-mass ratio (CMR) values than identically shaped electrodes made from either copper or graphite. The optimal stainless steel electrode inner diameter was 100 mm. The 304L stainless-steel electrode with this optimal diameter and a height of 45 mm achieved the highest mean CMR of 0.435 ± 0.002 mC kg-1 at an applied voltage of -11 kV with the bottom of the nozzle tip positioned 15 mm below the top of the electrode.

12.
J Clin Ultrasound ; 2022 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-36054721

RESUMO

OBJECTIVE: To explore the ultrasonographic features of primary hepatic undifferentiated pleomorphic sarcoma (UPS) to increase the rate of accurate clinical diagnosis. METHODS: We analyzed all (n = 7) primary hepatic UPS cases who attended Our Hospital from 2010 to 2021 in terms of morphology, size, echogenicity, borders, blood flow signal, posterior echoes, and other ultrasonographic features. RESULTS: All studied masses were solitary and mainly invaded one lobe of the liver. All the masses had diameters exceeding 5.0 cm and were nonencapsulated. They mostly had clear borders and regular morphologies (6 of 7 [85.7%]). Echogenicity was hypoechoic (2 of 7 [28.6%]) or heterogeneous (5 of 7 [71.4%]). Echogenicity was enhanced at the posterior aspect in all cases. None of the cases exhibited calcification, but some showed mass liquefaction (2 of 7 [28.6%]). Blood flow signal from the mass was rich (2 of 7 [28.6%]), mild (2 of 7 [28.6%]) or minimal (3 of 7 [42.9%]). One case in this study underwent CEUS. The margins and the internal septa, and mural or septal nodules of the mass showed mild hyperenhancement in the arterial phase and portal venous phase, but mild hypoenhancement in late phase. There were large nonenhancing areas in all three phases. CONCLUSION: When ultrasonography reveals a solitary, relatively large, regular, and nonencapsulated mass, primary hepatic UPS should be a differential diagnosis. Combining clinical findings with imaging modalities can increase the likelihood of an accurate diagnosis.

13.
World Neurosurg ; 2022 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-36055619

RESUMO

OBJECTIVES: To propose a new standardized technique for evaluating lumbar stability in degenerative lumbar spondylolisthesis using lumbar lateral flexion-extension radiographs with brackets and magnetic resonance facet fluid. METHODS: A retrospective analysis of 57 patients diagnosed with lumbar (L4-5) spondylolisthesis was performed. We analyzed lateral flexion-extension radiographs obtained with a bracket (LFEB) and without a bracket (LFE). Sagittal translation, segmental angulation, posterior opening, lumbar instability, and changes in lumbar lordosis were compared using functional radiographs. The mean width and maximum width of the facet fluid, mean facet joint length, and facet fluid index (FFI) of the two groups were compared using sagittal translation. RESULTS: The average value of sagittal translation was 1.68±0.96 mm in LFE and 3.07±1.29 mm in LFEB, and the difference was significant (p<0.05). Segmental angulation, posterior opening, and changes in lumbar lordosis were significantly greater in LFEB than in LFE. The instability detection rate was 14.0% in LFE and 35.1% in LFEB. The FFI, maximum width, and mean width were significantly increased in the unstable lumbar spondylolisthesis group compared with the stable group in LFEB. The FFI and maximum width of the facet fluid were significantly increased in the unstable lumbar spondylolisthesis group compared with the stable group in LFE. CONCLUSIONS: Lumbar lateral flexion-extension radiographs with brackets can standardize the operation process and provide sufficient hyperflexion and hyperextension images. The width of the facet fluid and FFI are significant factors in the evaluation of lumbar stability in patients with lumbar spondylolisthesis.

14.
Neurol Ther ; 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36048333

RESUMO

INTRODUCTION: Parental stress following critical illness in their child has the potential to impact functional outcomes and quality of life for the child and whole family. Parent emotional functioning may also be an important clinical target to optimize child outcomes. This study assessed the effectiveness of training programs for parents aimed at reducing adverse psychological outcomes in parents of children with acute brain injury (ABI). METHODS: We conducted searches of Embase, PubMed, Web of Science, and Cochrane Library to November 13, 2020. Randomized controlled trials (RCTs) that compared parent training programs with usual care, or an active comparator, and assessed psychological outcomes (depression, anxiety, stress) in parents of children with ABI were included. Two reviewers independently extracted data on study characteristics, participants, interventions, outcome measures, and results before and after intervention. Risk of bias was assessed using the Cochrane risk-of-bias tool. RESULTS: Four RCTs involving 318 parents of children with ABI were eligible for review. Compared with usual care or active comparator, parent training was associated with significant reduction in parent stress (four RCTs; standardized mean difference [SMD], - 0.32 on a numerical rating scale [95% CI, - 0.60, - 0.05]; I-squared = 7.5%, p = 0.356); significant reduction in parent depression (three RCTs; SMD, - 0.43 [95% CI, - 0.72, - 0.14]; I-squared = 0.0%, p = 0.393); and significant reduction in parent anxiety (two RCTs; SMD, - 0.63 [95% CI, - 1.05, - 0.21]; I-squared = 0.0%, p = 0.629). Overall risk of bias was high for randomization process (one RCT), missing outcome data (three RCTs), measurement of the outcome (three RCTs), and selection of reported result (two RCTs). Heterogeneity between studies by country of study origin was not significant. CONCLUSIONS: Compared with usual care or an active comparator, parent training was associated with short-term reduction in stress, depression, and anxiety in parents of children with ABI. Future clinical trials of parent interventions are needed as there may be some short-term beneficial effects.

15.
JAMA Oncol ; 2022 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-36074473

RESUMO

Importance: The Centers for Disease Control and Prevention (CDC) released an opioid-prescribing guideline in March 2016. Little is known about the guideline's potential effects on childhood cancer survivors, a population at high risk for pain. Objective: To examine changes in opioid prescriptions and potential misuse/substance use disorders (SUD) among childhood cancer survivors and peers without cancer following the guideline release. Design, Setting, and Participants: In this cohort study using the MarketScan Commercial Claims and Encounters Database, 8969 survivors who completed treatment for hematologic, central nervous system, bone, or gonadal cancers (aged ≤21 years at diagnosis) from 2009 to 2018 and 44 845 age-matched, sex-matched, and region-matched individuals without cancer were identified. With data aggregated based on the quarter-year of survivors' treatment completion, interrupted time series analyses were conducted in this cohort study to estimate the immediate (level) change and change in time trend (trend change) for each outcome after the guideline release, accounting for autocorrelation. Data were analyzed from September 2021 to April 2022. Exposures: Release of the CDC opioid-prescribing guideline. Main Outcomes and Measures: Outcomes included any opioid prescription and any indicator for potential misuse/SUD within 1 year following completion of treatment. Results: This study included 8969 childhood cancer survivors (mean [SD] age, 13.7 [6.2] years old; 3814 [42.5%] female patients) and 44 845 peers without cancer (mean [SD] age, 13.7 [6.2] years old; 19 070 [42.5%] female patients). Before the guideline release, the opioid prescription rate (21.1% vs 7.2%) and rate of potential misuse/SUD (5.6% vs 1.9%) were higher among survivors than peers without cancer. After the guideline release, the trend in opioid prescription rate declined among survivors (trend change, -1.1 percentage points [ppt]; P < .001; 95% CI, -1.5 to -0.7). Survivors also experienced an immediate level decrease (-2.1 ppt; P = .04; 95% CI, -4.2 to -0.1) and a decreasing trend (trend change, -0.4 ppt; P = .009; 95% CI, -0.6 to -0.1) in rate of potential misuse/SUD. Peers without cancer experienced decreasing trends in opioid prescription rate (trend change, -0.3 ppt; P < .001; 95% CI, -0.5 to -0.1) and rate of potential misuse/SUD (trend change, -0.1 ppt; P = .03; 95% CI, -0.1 to -0.01). By 2 years after the guideline release, relative reductions in opioid prescription rate and rate of potential misuse/SUD among survivors were 36.7% and 65.4%, respectively, with peers without cancer experiencing smaller reductions (15.9% and 29.9%). Conclusions and Relevance: In this cohort study, the opioid prescription rate and rate of potential misuse/SUD declined among both survivors and peers without cancer following the CDC guideline release, with survivors experiencing greater reductions. More research is needed to understand the guideline's potential effects on access to opioids required for pain control among childhood cancer survivors.

16.
Front Plant Sci ; 13: 974339, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36119622

RESUMO

As an important method for crop phenotype quantification, three-dimensional (3D) reconstruction is of critical importance for exploring the phenotypic characteristics of crops. In this study, maize seedlings were subjected to 3D reconstruction based on the imaging technology, and their phenotypic characters were analyzed. In the first stage, a multi-view image sequence was acquired via an RGB camera and video frame extraction method, followed by 3D reconstruction of maize based on structure from motion algorithm. Next, the original point cloud data of maize were preprocessed through Euclidean clustering algorithm, color filtering algorithm and point cloud voxel filtering algorithm to obtain a point cloud model of maize. In the second stage, the phenotypic parameters in the development process of maize seedlings were analyzed, and the maize plant height, leaf length, relative leaf area and leaf width measured through point cloud were compared with the corresponding manually measured values, and the two were highly correlated, with the coefficient of determination (R 2) of 0.991, 0.989, 0.926 and 0.963, respectively. In addition, the errors generated between the two were also analyzed, and results reflected that the proposed method was capable of rapid, accurate and nondestructive extraction. In the third stage, maize stem leaves were segmented and identified through the region growing segmentation algorithm, and the expected segmentation effect was achieved. In general, the proposed method could accurately construct the 3D morphology of maize plants, segment maize leaves, and nondestructively and accurately extract the phenotypic parameters of maize plants, thus providing a data support for the research on maize phenotypes.

17.
BMJ Open ; 12(9): e060955, 2022 09 17.
Artigo em Inglês | MEDLINE | ID: mdl-36115673

RESUMO

INTRODUCTION: Liver resection is the mainstay of curative-intent treatment for hepatocellular carcinoma (HCC), but the postoperative 5-year recurrence rate reaches 70%, and there are no adjuvant or neoadjuvant therapies recommended by major HCC guidelines that can reduce the risk of recurrence. In the recent decade, significant progress has been achieved in the systemic treatment of HCC, mainly from immune checkpoint inhibitors (ICIs) and targeted therapy. In other malignancies, ICIs in the neoadjuvant setting have shown better outcomes than in the adjuvant setting. On the other hand, the addition of radiation to ICIs incrementally improves the systemic response to ICIs. Neoadjuvant therapy of ICIs plus stereotactic body radiotherapy (SBRT) has shown promising results in several types of solid tumours but not HCC. METHODS AND ANALYSIS: Here, we describe a phase Ib clinical trial of neoadjuvant SBRT plus PD-1 (tislelizumab) prior to hepatic resection in HCC patients. Prior to resection, eligible HCC patients will receive 8 Gy×3 fractions of SBRT together with two cycles of tislelizumab with an interval of 3 weeks. HCC resection is scheduled 4 weeks after the second dose of tislelizumab, followed by adjuvant tislelizumab for 1 year. We plan to enrol 20 participants in this trial. The primary study endpoints include the delay of surgery, tumour response and safety and tolerability of the sequential SBRT/tislelizumab. Other endpoints are the disease-free survival and overall survival rates every 3 or 6 months after the surgery. ETHICS AND DISSEMINATION: This trial was approved by the Ethics Committee of Shandong Cancer Hospital and Institute (SDZLEC2022-021-01). The final results of this trial will be published in a peer-reviewed journal after completion. TRIAL REGISTRATION NUMBER: NCT05185531.


Assuntos
Carcinoma Hepatocelular , Neoplasias Hepáticas , Radiocirurgia , Anticorpos Monoclonais Humanizados , Carcinoma Hepatocelular/patologia , Ensaios Clínicos Fase I como Assunto , Humanos , Inibidores de Checkpoint Imunológico , Terapia Neoadjuvante , Receptor de Morte Celular Programada 1 , Radiocirurgia/métodos
18.
Polymers (Basel) ; 14(17)2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36080680

RESUMO

The operating safety of spacecraft in space environments is closely related to the surface discharging phenomenon of dielectrics such as polyimide (PI) film in solar arrays; moreover, carrier traps in the dielectric can affect its insulation performance. Therefore, to improve the vacuum surface flashover characteristics of PI film by nano modification and reveal the effect of trap distribution on the flashover of PI composite film, first, the original PI and nano-ZnO/PI composite films with different additive amounts (0.5, 1, 2, and 3 wt.%) were prepared by in situ polymerization and their performance was evaluated by the physicochemical properties characterized by methods such as thermogravimetric analysis; second, the surface traps of the original and nanocomposite films were measured and calculated by surface potential decay method, and the carrier mobility was also obtained; finally, the vacuum direct current (DC) surface flashover characteristics and bulk resistivity of all the film samples were measured and analyzed. The experiment results showed that with the increase in the amount of nano-ZnO, both the shallow and deep trap density increased significantly, while the trap energy varied slightly, and the surface flashover voltage also increased obviously. Based on the multi-core model, the increases in the shallow and deep trap density after the introduction of nano-ZnO into the PI matrix was analyzed from the microscopic perspective of the interface. Based on the comparative analysis of the trap distribution and surface flashover voltage characteristics, a bilayer model of vacuum DC surface flashover development was proposed. In the bilayer model, deep traps and shallow traps play a dominant role in the vacuum-solid interface and the inner surface of the dielectric, respectively, and increasing the trap density could effectively inhibit secondary electron multiplication on the surface and accelerate charge dissipation inside the film. Consequently, nano-ZnO can purposefully control the trap distribution, and then improve the flashover characteristics of nano-ZnO/PI composite films, which provides a new approach for improving the spacecraft material safety.

19.
Sensors (Basel) ; 22(17)2022 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-36080807

RESUMO

A wireless vision sensor network (WVSN) is built by using multiple image sensors connected wirelessly to a central server node performing video analysis, ultimately automating different tasks such as video surveillance. In such applications, a large deployment of sensors in the same way as Internet-of-Things (IoT) devices is required, leading to extreme requirements in terms of sensor cost, communication bandwidth and power consumption. To achieve the best possible trade-off, we propose in this paper a new concept that attempts to achieve image compression and early image recognition leading to lower bandwidth and smart image processing integrated at the sensing node. A WVSN implementation is proposed to save power consumption and bandwidth utilization by processing only part of the acquired image at the sensor node. A convolutional neural network is deployed at the central server node for the purpose of progressive image recognition. The proposed implementation is capable of achieving an average recognition accuracy of 88% with an average confidence probability of 83% for five subimages, while minimizing the overall power consumption at the sensor node as well as the bandwidth utilization between the sensor node and the central server node by 43% and 86%, respectively, compared to the traditional sensor node.


Assuntos
Compressão de Dados , Processamento de Imagem Assistida por Computador , Redes Neurais de Computação
20.
J Diabetes Res ; 2022: 2545476, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36090589

RESUMO

Traditional Chinese medicine (TCM) has long been used to treat diabetes mellitus and angina. It has also gained widespread clinical applications in China as a common adjuvant treatment. Although there is high-quality evidence that TCM is effective in regulating glucose and lipid metabolism, the cardiovascular protective effect of TCM in the treatment of diabetes mellitus has not been fully elucidated, especially in patients with both diabetes mellitus and coronary heart disease (CHD). We systematically assessed the efficacy and safety of TCM for the adjuvant treatment of patients with CHD and diabetes mellitus and examined the pharmacological effects and potential mechanisms of TCM medication/herbs on diabetes mellitus with CHD. We found that TCM could improve the control effect of conventional treatment on cardiac function, hemorheology, blood glucose, blood lipid, and inflammation, thus reducing the frequency of angina and the incidence of cardiovascular events and all-cause mortality. These findings indicate that TCM may be used as a complementary approach for patients with diabetes mellitus and CHD. Nevertheless, more rigorously designed randomized controlled trials and long-term evaluations are needed to support these findings.


Assuntos
Doença das Coronárias , Diabetes Mellitus , Glicemia , Doença das Coronárias/complicações , Doença das Coronárias/tratamento farmacológico , Diabetes Mellitus/tratamento farmacológico , Diabetes Mellitus/epidemiologia , Humanos , Incidência , Medicina Tradicional Chinesa
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