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1.
J Transl Med ; 17(1): 298, 2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31470866

RESUMO

BACKGROUND: BRAF mutations occur in 2-4% non-small cell lung cancer (NSCLC) patients and can be categorized into three functional classes based on signaling mechanism and kinase activity: RAS-independent kinase-activating V600 monomers (class 1), RAS-independent kinase-activating dimers (class 2) and RAS-dependent kinase-inactivating heterodimers (class 3). The association between functional classes and clinical features in Chinese NSCLC patients remains unexplored. Our multi-center study aimed to survey the BRAF mutation rate and analyze the associated clinical features in this population. METHODS: Capture-based sequencing data of either plasma or tissue samples obtained from 8405 Chinese stage I-IV NSCLC patients were retrospectively analyzed. RESULTS: BRAF mutations were detected in 238 patients, revealing an overall mutation rate of 2.8%. Among them, 32%, 21% and 13% had BRAF mutant class 1, 2 and 3 respectively. The remaining 34% had other BRAF mutations. V600 (32%) and G469 (13%) were the two most predominant BRAF mutations. Patients with class 2 and 3 mutations were more likely to have concurrent KRAS mutations (P = 0.001). Collectively, BRAF mutations, including non-class 1-3 mutations, were more likely to occur in males (P < 0.01). However, females were more likely to harbor class 1 mutations (P < 0.02). We also compared the overall survival (OS) of first-line chemotherapy-treated advanced-stage patients and revealed comparable OS among the three groups. CONCLUSION: Our study revealed a 2.8% BRAF mutation rate in Chinese NSCLC patients. Our data also showed a male predominance when all BRAF mutations were considered collectively, and a female predominance for class 1 mutations. Furthermore, BRAF V600E is less likely to have concurrent KRAS mutations comparing to the other two classes.

2.
Nanotechnology ; 30(46): 465401, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31479422

RESUMO

Graphene and Au nanorods (AuNRs) coated with SiO2@TiO2 double shells (AuNR@SiO2@TiO2) were incorporated to form novel composite photoanodes in dye sensitized solar cells (DSSCs). The performances of the photoanodes and DSSCs are studied systematically. The short circuit current density (J sc) and power conversion efficiency (PCE) of these composited DSSCs were greatly enhanced and the influences of the graphene, AuNRs and the SiO2@TiO2 double shells were revealed. The optimal properties with the maximal J sc of 16.26 mA cm-2 and PCE of 8.08% are obtained in the DSSC co-doped with graphene and AuNR@SiO2@TiO2, significantly higher than those of the conventional DSSC with pure TiO2 photoanode by 37.7% and 32.9%, respectively. These significant enhancements in J sc and PCE are attributed to the synergistic effect of graphene, the local surface plasma resonance of AuNRs, as well as the outer SiO2@TiO2 double shells, which result in the increased specific surface area and dye adsorption, the increased light absorption, the decreased charge transfer resistance R 2 and electron recombination and thus the increased J sc and PCE of the DSSCs.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31484172

RESUMO

The magnetoelectric effect in the RX3(BO3)4 system (R= Ho, Eu, Sm, Nd, Gd; X= Fe, Al) varies significantly with the cation R despite very similar structural arrangements. Our structural studies reveal a symmetry reducing tilting of the BO3 planes and of the FeO6 polyhedra in the systems exhibiting low magnetic field induced electric polarization. We develop an atomic-level description of the structure related mechanism behind the magnetoelectric effect, and propose a possible method for enhancement of the electric polarization. Neutron scattering measurements reveal a lack of magnetic ordering indicating the primary importance of the atomic structure in the multiferroic behavior of this system.

4.
Nanoscale ; 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31478547

RESUMO

Zero-dimensional (0D)-2D nanostructures, which combine the efficient light-harvesting properties of 0D nanocrystals (NCs) and the ultrafast carrier transfer of 2D materials, have been widely used in optoelectronic devices. Although the most common way to fabricate 0D-2D nanostructures consists of a mixing process, the limited loading efficiency of NCs and the poor 0D-2D interface hinder the efficient photo-carrier generation and fast carrier separation/transfer in such systems. Herein, the in situ synthesis of CsPbBr3/BP heterostructures via a hot-injection method was presented, revealing that both the formation process of CsPbBr3 NCs and the CsPbBr3/black phosphorous (BP) interfaces presented pronounced changes. This led to a larger CsPbBr3 NC size, higher CsPbBr3 NC loading efficiency, optimized combination of CsPbBr3 and BP at the interface, and enhanced carrier transfer properties. In addition, the in situ synthesized CsPbBr3/BP heterostructure was used as a photoactive material for the fabrication of photodetectors, which showed high detectivity (D*) of 2.6 × 1011 Jones. This work highlights a novel strategy to optimize the 0D-2D heterostructure interface and to promote its carrier transfer efficiency, broadening the field of the applications of mixed-dimensional nanostructures.

5.
Chin Med J (Engl) ; 2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31478926

RESUMO

BACKGROUND: Thyroid autoimmunity (TAI) is prevalent among women of reproductive age and associated with adverse pregnancy outcomes. This study aimed to investigate the association between iron nutritional status and the prevalence of TAI in women during the first trimester of pregnancy and in non-pregnant women of childbearing age. METHODS: Cross-sectional analysis of 7463 pregnant women during the first trimester of pregnancy and 2185 non-pregnant women of childbearing age nested within the sub-clinical hypothyroid in early pregnancy study, a prospective collection of pregnant and non-pregnant women's data, was conducted in Liaoning province of China between 2012 and 2015. Serum thyrotropin, free thyroxine, thyroid peroxidase antibodies (TPOAbs), thyroglobulin antibodies (TgAbs), serum ferritin, and urinary iodine were measured. Iron deficiency (ID) was defined as serum ferritin <15 µg/L and iron overload (IO) was defined as ferritin >150 µg/L. TPOAb-positive was defined as >34 U/mL and TgAb-positive was defined as >115 U/mL. Multilevel logistic regression was conducted to examine the association between TAI and different iron nutritional status after adjusting for potential confounders. RESULTS: The prevalence of isolated TPOAb-positive was markedly higher in women with ID than those without ID, in both pregnant and non-pregnant women (6.28% vs. 3.23%, χ = 10.264, P = 0.002; 6.25% vs. 3.70%, χ = 3,791, P = 0.044; respectively). After adjusting for confounders and the cluster effect of hospitals, ID remained associated with TPOAb-positive in pregnant and non-pregnant women (odds ratio [OR]: 2.111, 95% confidence interval [CI]: 1.241-3.591, P = 0.006; and OR: 1.822, 95% CI: 1.011-3.282, P = 0.046, respectively). CONCLUSION: ID was associated with a higher prevalence of isolated TPOAbs-positive, but not with isolated TgAb-positive, in both pregnant women during the first trimester of pregnancy and non-pregnant women of childbearing age, while IO was not associated with either isolated TPOAb-positive or isolated TgAb-positive. CLINICAL TRIAL REGISTRATION: ChiCTR-TRC-13003805, http://www.chictr.org.cn/index.aspx.

6.
Metab Brain Dis ; 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31482248

RESUMO

Alzheimer's disease (AD), a chronic, progressive, neurodegenerative disorder, is the most common type of dementia. Beta amyloid (Aß) peptide aggregation and phosphorylated tau protein accumulation are considered as one of the causes for AD. Our previous studies have demonstrated the neuroprotective effect of the Rho kinase inhibitor fasudil, but the mechanism remains elucidated. In the present study, we examined the effects of fasudil on Aß1-42 aggregation and apoptosis and identified the intracellular signaling pathways involved in these actions in primary cultures of mouse hippocampal neurons. The results showed that fasudil increased neurite outgrowth (52.84%), decreased Aß burden (46.65%), Tau phosphorylation (96.84%), and ROCK-II expression. In addition, fasudil reversed Aß1-42-induced decreased expression of Bcl-2 and increases in caspase-3, cleaved-PARP, phospho-JNK(Thr183/Tyr185), and phospho-ASK1(Ser966). Further, fasudil decreased mitochondrial membrane potential and intracellular calcium overload in the neurons treated with Aß1-42. These results suggest that inhibition of Rho kinase by fasudil reverses Aß1-42-induced neuronal apoptosis via the ASK1/JNK signal pathway, calcium ions, and mitochondrial membrane potential. Fasudil could be a drug of choice for treatment of Alzheimer's disease.

7.
Nanoscale ; 2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31482929

RESUMO

Inspired by the experimental growth of two-dimensional (2D) tellurene (Yixin et al., Nat. Electron, 2018, 1, 228-236) and the recent study of unusually low thermal conductivity of atomically thin 2D tellurium (Jie Ren et al., Nanoscale, 2018, 10, 12997), we carried out systematic calculations for monolayer ß-tellurene, focusing on its electrical transport and electronic and thermoelectric properties by means of density functional theory (DFT) combined with deformation potential theory and Boltzmann transport theory. We have found that monolayer ß-tellurene exhibits a band gap of 1.5 eV. The carrier transport is highly direction-temperature-dependent, with a high room-temperature transport mobility of 1343 cm2 V-1 s-1 and a relaxation time of 283 fs in the armchair direction for hole transport at room-temperature. It is coincidently favourable in the armchair direction for both the Seebeck coefficient and the electrical conductivity, making the p-type monolayer ß-tellurene a highly promising thermoelectric candidate. With a low intrinsic lattice thermal conductivity, the maximum figure of merit (ZT) is 2.9 and 0.84 along the armchair and zigzag directions for p-type doping at 700 K, respectively. The predicted properties demonstrate that monolayer ß-tellurene can be a prospective material towards thermoelectric applications.

8.
Nat Commun ; 10(1): 4062, 2019 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-31492855

RESUMO

The growth and wetting of water on two-dimensional(2D) materials are important to understand the development of 2D material based electronic, optoelectronic, and nanomechanical devices. Here, we visualize the liquefaction processes of water on the surface of graphene, MoS2 and black phosphorus (BP) via optical microscopy. We show that the shape of the water droplets forming on the surface of BP, which is anisotropic, is elliptical. In contrast, droplets are rounded when they form on the surface of graphene or MoS2, which do not possess orthometric anisotropy. Molecular simulations show that the anisotropic liquefaction process of water on the surface of BP is attributed to the different binding energies of H2O molecules on BP along the armchair and zigzag directions. The results not only reveal the anisotropic nature of water liquefaction on the BP surface but also provide a way for fast and nondestructive determination of the crystalline orientation of BP.

9.
Chem Commun (Camb) ; 2019 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-31495843

RESUMO

A host-guest inclusion compound, 18-crown-6 oxonium tetrachloride-gallium(iii), was shown to undergo a 4/mmmFmm2-type ferroelectric phase transition with four crystallographically equivalent polarization directions at 337 K. To the best of our knowledge, this is the first host-guest inclusion compound shown to be a high-temperature multiaxial molecular ferroelectric.

10.
Plant Biotechnol J ; 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31487419

RESUMO

Understanding the genetic basis underlying its agronomic traits will provide critical molecular insights for alfalfa breeding. Nine agronomic traits were characterized across 322 alfalfa genotypes in three consecutive years. Phenotypic data analysis revealed that all 9 traits were significantly influenced by genotype and were of variable heritability. A total of 44,757 SNPs was identified and uniquely physically mapped to the Medicago truncatula reference genome. Population structure analysis showed that the entire collection could be divided into two subpopulations consistent with their geographic origins. Genome-wide association analysis identified 42 significant associated markers with agronomic traits. Two candidate genes associated with the SNPs were also identified, cloned and characterized transgenically in the model plant Arabidopsis thaliana. Overexpression of the gene MsACR11 in A. thaliana increased plant height compared with the wild-type. Quantitative reverse transcription polymerase chain reaction analysis results showed that MsACR11 up-regulated the transcription of GLN2, which encodes glutamine synthetase 2. The gene MsPB1 increased plant branching when overexpressed in A. thaliana. Taken together, the results of our study demonstrate that integrating GBS and GWAS can be a powerful approach for dissecting agronomic traits in alfalfa, and the results will be valuable for further characterization of candidate genes and to assist in alfalfa breeding. This article is protected by copyright. All rights reserved.

11.
J Pharmacol Exp Ther ; 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31488603

RESUMO

Recent imaging studies of amyloid and tau in cognitively normal elderly subjects imply that Alzheimer's pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating at the cellular and synaptic levels. The present study investigated the effects of an allosteric inhibitor of PDE4D known as BPN14770 on impairment of memory, dendritic structure, and synaptic proteins induced by bilateral microinjection of oligomeric Aß 1-42 into the hippocampus of humanized PDE4D (hPDE4D) mice. The humanized PDE4D mice provide a unique and powerful genetic tool for assessing PDE4D target engagement. Behavioral studies showed that treatment with BPN14770 significantly improved memory acquisition and retrieval in the Morris water maze test and the percentage of alternations in the Y-maze test in the model of Aß-impairment. Microinjection of oligomeric Aß1-42 caused decreases in the number of dendrites, dendritic length, and spine density of pyramid neurons in the hippocampus. These changes were prevented by BPN14770 in a dose-dependent manner. Furthermore, molecular studies showed that BPN14770 prevented Aß-induced decreases in synaptophysin, PSD-95, pCREB/CREB, BDNF, and VGF levels in the hippocampus. The protective effects of BPN14770 against Aß-induced memory deficits, synaptic damage, and the alteration in the cAMP-meditated cell signaling cascade were blocked by H-89, an inhibitor of protein kinase A (PKA). These results suggest that BPN14770 may activate compensatory mechanisms that support synaptic health even with the onset of amyloid pathology in Alzheimer's disease. SIGNIFICANCE STATEMENT: This study demonstrates that a phosphodiesterase-4D (PDE4D) allosteric inhibitor BPN14770 protects against memory loss and neuronal atrophy induced by oligomeric Aß 1-42. The study provides useful insight into the potential role of compensatory mechanisms in Alzheimer's disease in a model of oligomeric Aß 1-42 neurotoxicity.

12.
Artigo em Inglês | MEDLINE | ID: mdl-31504670

RESUMO

Aerobic glycolysis is a characteristic in cancers that is important for cancer cell proliferation. Emerging evidence shows that long non-coding RNA (LncRNA) participates in glucose metabolism and cell proliferation in cancer. This study explored the effect of LncRNA: SNHG9 in glioblastoma. The mRNA expression of SNHG9 in human glioma tissues and glioblastoma cell lines was measured by qRT-PCR. Glioblastoma cell lines (U87 and U251) were transfected with miR-199a-5p or SNHG9-expressing plasmid and cell viability as well as concentrations of glucose and lactate were measured. The extracellular acidification was evaluated by glycolysis stress test. The Wnt2 levels were determined by qRT-PCR and Western blot. Results showed that the mRNA expression of SNHG9 was elevated in glioblastoma tissues. The elevated SNHG9 expression was related to lower survival rate in patients with glioma. SNHG9 could downregulate miR-199a-5p and upregulate Wnt2 in glioblastoma cells. Overexpression of SNHG9 in glioblastoma cells promoted aerobic glycolysis and cell proliferation, which could be attenuated by miR-199a-5p. Results of this study indicated an effect of SNHG9/miR-199a-5p/Wnt2 axis in regulating cell growth and aerobic glycolysis in glioblastoma.

13.
Math Biosci Eng ; 16(5): 6103-6120, 2019 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-31499754

RESUMO

Robustness is an important property of image hashing. Most of the existing hashing algorithms do not reach good robustness against large-angle rotation. Aiming at this problem, we jointly exploit visual attention model and ring partition to design a novel image hashing, which can make good rotation robustness. In the proposed image hashing, a visual attention model called PFT (Phase spectrum of Fourier Transform) model is used to detect saliency map of preprocessed image. The LL sub-band of saliency map is then divided into concentric circles invariant to rotation by ring partition, and the means and variances of DWT coefficients on concentric circles are taken as image features. Next, these features are encrypted by a chaotic map and the Euclidean distances between normalized encrypted features are finally exploited to generate hash. Similarity between hashes is measured by L 1 norm. Many experimental tests show that our image hashing is robust to digital operations including rotation and reaches good discrimination. Comparisons demonstrate that classification performance of our image hashing outperforms those of some well-known hashing algorithms in terms of receiver operating characteristics curves. Simulation of image copy detection is carried out on an open image database called UCID and the result validates effectiveness of our hashing.

14.
Appl Opt ; 58(24): 6545-6548, 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31503583

RESUMO

This Nd:BG1-xSxO (Nd:BGSO) crystal was grown using the micro-pulling-down method, and the continuous-wave laser operation of this crystal was demonstrated for the first time, to the best of our knowledge. The maximum output power of 1.038 W was obtained under the absorbed pump power of 3.01 W, which corresponds to a slope efficiency of 31.3%. Bismuth nanosheets were first employed as saturable absorbers to generate a passively Q-switched Nd:BGSO laser. Stable Q-switched pulses with the shortest pulse width of 376.5 ns and the maximum repetition rate of 136.6 kHz were achieved at the absorbed pump power of 3.01 W. The largest pulse energy and highest peak power achieved were 0.94 µJ and 2.48 W, respectively.

15.
J Otolaryngol Head Neck Surg ; 48(1): 43, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31477184

RESUMO

BACKGROUND: Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have suggested an association between marijuana use and HPV-related OPSCC. Despite this, no study has examined the potential relationship between marijuana use and survival in this subset of patients. OBJECTIVE: To examine the survival outcomes of HPV-related OPSCC patients in marijuana users. METHODS: Patients who were marijuana users were identified from a prospectively collected database of HNC patients from January 2011 to 2015. A physical review of clinic records was undertaken to extract relevant patient, tumor, treatment, follow-up, as well as survival data. Patients greater than 17 years of age with pathologically proven p16 positive OPSCC were included. They were then case-matched in a 1-to-1 basis to patients who were non-marijuana users based on age, gender, and cTNM staging. RESULTS: Forty-Seven patients met inclusion criteria within each group. Univariate logistic regression analysis showed that age, gender, and cT-Stage were predictive of disease recurrence within both groups (p < 0.05). However, cN-stage, treatment modality, tumor subsite, tobacco use, and tobacco dose were not (p > 0.05). There was no statistically significant difference between marijuana and non-marijuana user groups in 5-year (p = 0.400) overall survival, disease-specific (p = 0.993), disease-free (p = 0.404), and metastasis-free survival (p = 0.384). CONCLUSIONS: No survival difference is found between HPV-related OPSCC marijuana users and non-users. This finding has implications for both de-escalation regimes and the use of cannabis as a therapeutic agent.

16.
Gene ; 720: 144088, 2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31476404

RESUMO

BACKGROUND: Secretory leukocyte protease inhibitor (SPLI) was a secreted protein which belongs to a member of whey acidic protein four-disulfide core family. In breast cancer (BC) it may inhibit cell proliferation and promote cancer metastasis. In this study, a comprehensive bioinformatics analysis was performed to identify the expression and prognostic value of SLPI in breast cancer. METHODS: SLPI expression in breast cancer was analyzed in Oncomine online database, which was subsequently confirmed by quantitative PCR (qPCR) in 18 BC samples and western blotting in 26 BC samples. Breast cancer gene-expression miner v4.1 was used to access the expression level with clinicopathological parameters in breast cancer patients. The prognostic values of SLPI in breast cancer were evaluated using the PrognoScan database. RESULTS: Our results indicated that SLPI was downregulated in breast cancer than in normal tissues. SLPI expression was found to be negatively correlated with estrogen receptor (ER) and progesterone receptor (PR) status. SLPI expression level was decreased in negative basal-like status patients compared with positive basal-like status. Meanwhile, triple-negative breast cancer status positive correlated with SLPI. We confirmed a positive correlation between SLPI and interleukin 17 receptor B (IL17RB) express in breast cancer tissues via oncomine co-expression analysis. Ten proteins: Elastase, Granulin, Lipocalin, Defensin beta 103B, Defensin beta 103A, Tubulin, Heparin-binding EGF-like growth factor, Interleukin 6, Epidermal growth factor, Phospholipid scramblase 1 were determinate interactions with SLPI by STRING. CONCLUSION: SLPI could as a biomarker to predict the prognosis values of breast cancer. However, further comprehensive study and mining more evidence are needed to clarify our results.

17.
Small ; : e1902237, 2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31389174

RESUMO

Halide perovskites have emerged as a type of extremely promising material for their diverse chemical and electronic structures along with their brilliant optoelectronic properties. The introduction of chirality into perovskite scaffolds, generating a novel concept of chiral perovskite materials, offers an immense step forward toward the development of smart optoelectronic and spintronic materials and devices. The present Review summarizes recent advances in such an emerging field regarding the design and construction of chiral perovskite materials, along with their optoelectronic performances. In addition, an outlook of future challenges as well as the potential significance of the chiral perovskite family on the optical communication is proposed.

18.
J Mol Model ; 25(8): 255, 2019 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-31367801

RESUMO

Dry powder fire-extinguishing agent is one of Halon substitutes due to its superior fire-extinguishing performance, non-toxicity, and environmental friendliness. As one of the most widely used dry powders, ABC dry powder has attracted wide attention. Understanding its reaction mechanism is important to the design of more efficient compound dry powder based on it. When ABC dry powder was applied to the flame, ammonium dihydrogen phosphate (the main fire-extinguishing component of ABC dry powder) would rapidly decompose into phosphoric acid (H3PO4) and ammonia. Therefore, in order to figure out the chemical reaction mechanism of ABC dry powder and active radicals, the main focus of this paper is on the H3PO4. Analysis of the electrostatic potential on van der Waals surface of H3PO4 was carried out. Besides, detailed theoretical investigation has been performed on the mechanism, kinetics, and thermochemistry of the reactions of H3PO4 with H, OH, and CH3 radicals and further decomposition of H3PO4 using M06-2X/6-311G(d,p)//CCSD(T)/cc-pVTZ level of theory. Mayer bond order for all intrinsic reaction coordinate points was also calculated. Finally, it is theoretically proved that ABC dry powder extinguishes the fire mainly by chemical inhibition on H and OH radicals. Grapical Abstract .

19.
Adv Mater ; : e1902352, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31368605

RESUMO

2D phosphorene, arsenene, antimonene, and bismuthene, as a fast-growing family of 2D monoelemental materials, have attracted enormous interest in the scientific community owing to their intriguing structures and extraordinary electronic properties. Tuning the monoelemental crystals into bielemental ones between group-VA elements is able to preserve their advantages of unique structures, modulate their properties, and further expand their multifunctional applications. Herein, a review of the historical work is provided for both theoretical predictions and experimental advances of 2D V-V binary materials. Their various intriguing electronic properties are discussed, including band structure, carrier mobility, Rashba effect, and topological state. An emphasis is also given to their progress in fabricated approaches and potential applications. Finally, a detailed presentation on the opportunities and challenges in the future development of 2D V-V binary materials is given.

20.
World Neurosurg ; 2019 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-31421295

RESUMO

OBJECTIVE: Hypothyroidism is widely believed to cause vascular endothelial disorders and atherosclerosis. The purpose of this study was to explore whether hypertensive patients with hypothyroidism may have a higher incidence of hypertensive intracerebral hemorrhage. METHODS: Cases of hypertensive intracerebral hemorrhage collected from neurology department and neurosurgery department of our hospital from January 1, 2018 to December 31 , 2018 were retrospectively collected, and a case-control study was conducted on an equal number of hypertensive patients without hypertensive intracerebral hemorrhage randomly selected through age matching in the same period, and the history of hypothyroidism and other common risk factors at admission were recorded. RESULTS: A total of 231 patients with hypertensive intracerebral hemorrhage were included and 231 patients with hypertension were selected for control according to the age matching and random screening principles. Hypothyroidism was present in 54(23.4%) patients and 33(14.3%) matched controls, multivariate logistic regression analysis showed that hypothyroidism was an independent risk factor for hypertensive intracerebral hemorrhage (OR=2.29, 95%CI(1.38-3.79), P=0.001). CONCLUSION: Hypothyroidism is independently associated with hypertensive intracerebral hemorrhage. In view of the known pathophysiological relationship between hypothyroidism and vascular endothelial dysfunction and atherosclerosis, further research and exploration are necessary.

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