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1.
Mikrochim Acta ; 186(12): 794, 2019 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-31734780

RESUMO

A photoelectrochemical (PEC) aptasensor is described for detecting tetracycline (TC). A gold nanoparticles/BiOBr (AuNPs/BiOBr) composite was prepared where the AuNPs play a key function in carrier transfer which is ascribed to the wavelength-dependent dual function as an electron sink and as a hot-electron donor. Due to this dual function, the composite exhibits a wide photo-response and high electron transfer efficiency. This results in enormously enhanced PEC response. The TC-aptamer was immobilized on an ITO modified with AuNPs/BiOBr via Au-S covalent bonding. The resulting PEC aptasensor possesses a wide linear range (1-104 ng L-1) and a low detection limit (0.35 ng L-1; at S/N = 3). Graphical abstractSchematic representation of a photoelectrochemical aptasensor for tetracycline based on the use of a AuNP/BiOBr composite with electron sink and hot-electron donor properties of the gold nanoparticles.

2.
Ann Vasc Surg ; 2019 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-31743780

RESUMO

BACKGROUND/OBJECTIVES: The acute exacerbations and progressive deterioration seen in thromboangiitis obliterans (TAO) have been related to poor clinical outcomes. Here, we have studied the association of laboratory biomarkers with the acute phase of TAO (AP-TAO). METHODS/RESULTS: We conducted a retrospective case-control study on 112 patients with TAO and 98 healthy controls; comparing the neutrophil-to-lymphocyte rate (NLR), lymphocyte-to-monocyte rate (LMR), platelet-to-neutrophil rate (PNR), fibrinogen (FIB) and apolipoprotein A-I (ApoA-I). Significantly higher NLR level, as well as lower LMR, PNR, ApoA-I levels were observed in patients with TAO, particularly the acute phase. Significantly increased FIB was only observed in AP-TAO. A positive correlation was found between NLR and with C-reactive protein (CRP) in the acute phase (r=0.817, p<0.001). Moreover, NLR, PNR and FIB levels of 3.38, 45.12 and 3.69 were shown to be the predictive cut-off values for the AP-TAO (sensitivity 72.5, 82,4 and 66,7%, specificity 92.2, 78.4 and 96.1%; area under the curve (AUC) 0.875, 0.855 and 0.872), respectively. FIB level was independently associated with the AP-TAO (OR = 11.420, p=0.007). CONCLUSIONS: NLR, PNR and FIB may be useful markers for the identification of inflammation and the AP-TAO. FIB may be an independent risk factor for the acute phase.

3.
Chem Commun (Camb) ; 55(91): 13737-13740, 2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31661086

RESUMO

A highly transparent and stretchable electrode based on a Au nanomesh, electrodeposited with a thin layer of MnO2 with a transparency of 84.7% is introduced. The as-prepared transparent, stretchable, and imperceptible supercapacitor (TSPS) exhibits a specific capacitance of 0.53 mF cm-2 and excellent bending stability, together with high stretchability (up to 160% strain).

4.
Cell Commun Signal ; 17(1): 125, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31610798

RESUMO

BACKGROUND: Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 transcriptionally regulated genes are largely unknown. METHODS: In this study, we performed a global transcriptional analysis using gene array technology to investigate the transcriptional role of CDK11 in osteosarcoma. The promoter luciferase assay, chromatin immunoprecipitation assay, and Gel Shift assay were used to identify direct transcriptional targets of CDK11. Clinical relevance and function of core-binding factor subunit beta (CBFß) were further accessed in osteosarcoma. RESULTS: We identified a transcriptional role of protein-DNA interaction for CDK11p110, but not CDK11p58, in the regulation of CBFß expression in osteosarcoma cells. The CBFß promoter luciferase assay, chromatin immunoprecipitation assay, and Gel Shift assay confirmed that CBFß is a direct transcriptional target of CDK11. High expression of CBFß is associated with poor outcome in osteosarcoma patients. Expression of CBFß contributes to the proliferation and metastatic behavior of osteosarcoma cells. CONCLUSIONS: These data establish CBFß as a mediator of CDK11p110 dependent oncogenesis and suggest that targeting the CDK11- CBFß pathway may be a promising therapeutic strategy for osteosarcoma treatment.

5.
Biosens Bioelectron ; 148: 111802, 2019 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-31665671

RESUMO

Ciprofloxacin (CIP) as a typical antibiotic is widely used to produce antimicrobial drugs. Determination of CIP has raised extensive concern due to its possible toxic effects on human health. Here, a simple photoelectrochemical (PEC) sensor for detecting CIP has been developed by using the nitrogen-deficient graphitic carbon nitride (ND-g-CN) as a PEC active material. The ND-g-CN material exhibits two-dimension (2D) thin sheet structure with abundant nitrogen vacancies. The 2D thin sheet structure can enable the effective charge separation and transfer, thus dramatically improving the PEC performance. Simultaneously, nitrogen vacancies can serve as charge trap to efficiently inhibit the charge recombination. Furthermore, the synergistic effect of the two can widen the absorption edge and decrease the band gap of ND-g-CN material, resulting in increasing light harvesting and enhancing PEC performance. CIP can be oxidized by the holes of ND-g-CN, thus realizing effective charge separation, which can result in the amplification of the photocurrent. The designed PEC sensor demonstrated a wide detection range from 60 to 19090 ng L-1 and a low detection limit of 20 ng L-1 for CIP assay. This strategy broadens the application of graphitic carbon nitride (g-CN) material in PEC field and presents a promising potential for the practical application in the environmental monitoring.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31514124

RESUMO

Detecting segments of interest from videos is a common problem for many applications. And yet it is a challenging problem as it often requires not only knowledge of individual target segments, but also contextual understanding of the entire video and the relationships between the target segments. To address this problem, we propose the Sequence-to-Segments Network (S2N), a novel and general end-to-end sequential encoder-decoder architecture. S2N first encodes the input video into a sequence of hidden states that capture information progressively, as it appears in the video. It then employs the Segment Detection Unit (SDU), a novel decoding architecture, that sequentially detects segments. At each decoding step, the SDU integrates the decoder state and encoder hidden states to detect a target segment. During training, we address the problem of finding the best assignment of predicted segments to ground truth using the Hungarian Matching Algorithm with Lexicographic Cost. Additionally, we propose to use the squared Earth Mover's Distance to optimize the localization errors of the segments. We show the state-of-the-art performance of S2N across numerous tasks, including video highlighting, video summarization, and human action proposal generation.

7.
J Pak Med Assoc ; 69(9): 1344-1348, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31511722

RESUMO

OBJECTIVE: To determine the therapeutic effects of pre-admission ticagrelor in acute ST elevation myocardial infarction after primary percutaneous coronary intervention. METHODS: The meta analysis was conducted at the period from the establishment of the database to the February 2018 period, and comprised earlier studies that were selected after comprehensive search of PubMed, Medline, Excerpta Medica dataBASE and Cochrane databases. The studies compared the pre-treatment group (pre-hospital ticagrelor) with the control group (in-hospital ticagrelor) and found differences in primary percutaneous coronary intervention outcomes for sick individuals suffering from acute ST elevation myocardial infarction. RESULTS: The two studies selected together had 1915 subjects. The rate of stent thrombosis in the control group was higher than in the pre-treatment group (p<0.01), but there were no significant differences in all-cause mortality (p=0.88), myocardial infarction (p=0.17) and stroke (p=0.49). CONCLUSIONS: Pre-hospital ticagrelor decreased the incidence of stent thrombosis in patients with acute ST elevation myocardial infarction who underwent primary percutaneous coronary intervention.

8.
Carbohydr Polym ; 225: 115230, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31521261

RESUMO

Rigid chitin nanofibers (ChNFs) self-assembled from dilute α-chitin/KOH/urea aqueous solution were utilized as 1D filler to reinforce soft natural rubber (NR). The prepared ChNFs suspension has good compatibility with natural rubber latex (NRL) and thus showing favorable dispersibility in NR matrix at nanoscale. The bio-nanocomposites were fabricated by casting and evaporating the pre-mixed NRL/ChNFs suspensions with different ChNFs loadings. Gratifyingly, the NR/ChNFs bio-nanocomposite with only 0.3 wt% ChNFs content presented distinct improvement in both the strength and toughness due to the large aspect ratio of ChNFs and its homogeneous dispersion in NRL matrix. Moreover, the introduction of ChNFs can promote the proliferation of mBMSCs effectively and endow NR/ChNFs bio-nanocomposites with good biocompatibility, enabling expanded applications of NR in biomedical field, such as artificial blood vessel, cosmetology prosthesis and human diaphragm materials.

9.
Br J Pharmacol ; 2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-31364164

RESUMO

BACKGROUND AND PURPOSE: Bruton's tyrosine kinase (BTK) plays a key role in B-cell receptor (BCR) signaling to regulate cell proliferation and survival in various B-cell malignancies. Covalent small-molecule BTK kinase inhibitors have shown impressive clinical efficacy in B-cell malignancies. However, the mutant BtkC481S poses a major challenge in the management of B-cell malignancies by disrupting the formation of the covalent bond between BTK and irreversible inhibitors, such as ibrutinib. The present studies were designed to develop novel BTK inhibitors targeting ibrutinib-resistant BtkC481S mutation EXPERIMENTAL APPROACH: BTK-Ba/F3, BTK(C481S)-Ba/F3 cells, and human malignant B-cells JeKo-1, Ramos and NALM-6 were used to evaluate cellular potency of BTK inhibitors. The in vitro pharmacological efficacy and compound selectivity were assayed via cell viability, colony formation, and BTK mediated signaling. The tumor xenograft model was used to profile the in vivo efficacy of reversible BTK inhibitors. KEY RESULTS: We identified a class of small molecules, represented by XMU-MP-3, as potent non-covalent BTK inhibitors. XMU-MP-3 showed its potential clinical utility overriding the acquired mutation of BTKC481S, both in vitro and in vivo. Further computational modeling, site-directed mutagenesis analysis, and structure-activity relationships studies indicate that XMU-MP-3 displays a typical type II inhibitor binding mode. CONCLUSION AND IMPLICATIONS: Mechanistically XMU-MP-3 exerts its pharmacological activity by directly targeting BTK signaling pathway in B-cell lymphoma. These findings establish XMU-MP-3 as a novel inhibitor of BTK, which could serve as both a tool compound as well as a lead for further drug development in BTK relevant B-cell malignancies, especially those characterized as having the acquired ibrutinib-resistant C481S mutation.

10.
J Hum Genet ; 64(11): 1067-1073, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31427716

RESUMO

Megacystis-microcolon-intestinal-hypoperistalsis syndrome (MMIHS) is a rare and severe disorder characterized by functional obstruction in the urinary and gastrointestinal tract. The molecular basis of this condition has been defined recently. Heterozygous variants in ACTG2, homozygous mutations in LMOD1, MYLK, and MYH9 were related to the pathogenesis of the syndrome, which encodes proteins involved in the process of smooth muscle contraction, supporting a myopathic basis for the disease. Recent studies have identified homozygous or compound heterozygous variants in MYH11 as a candidate gene of MMIHS. In this report, we described a nonconsanguineous Chinese family with three male fetuses affected with megacystis. Trio-targeted exome sequencing identified compound heterozygous variants, c.2051 G > A (p.R684H) and c.3540_3541delinsTT (p.(E1180D, Q1181Ter)), in MYH11 (NM_001040114). The variants were inherited from the parents, respectively. Western blotting showed a marked decrease in MYH11 protein in the proband's umbilical cord tissue compared with the control sample. The study's results confirmed that MYH11 is a candidate gene for MMIHS with autosomal recessive (AR) inheritance and expanded the mutation spectrum for this clinical condition. Combining clinical phenotype with molecular diagnosis may enable the identification of candidate genes for potential monogenic diseases and facilitate accurate genetic counseling, informed decision-making, and prenatal diagnosis.

11.
J Exp Clin Cancer Res ; 38(1): 296, 2019 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-31288861

RESUMO

BACKGROUND: Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment. However, IPO5, one of the karyopherin nuclear transport receptor family members, remains largely uncharacterized in tumour progression. METHODS: The TCGA data, quantitative reverse transcription-PCR (qRT-PCR), western blotting, and IHC analyses were used to detect IPO5 expression in CRC tissues. A series of in vivo and in vitro experiments was utilized to demonstrate the function of IPO5 in CRC tissues. Mass spectrometry (MS), CO-IP technology, subcellular fractionation, and immunofluorescence were utilized to investigate the possible mechanisms of CRC. RESULTS: IPO5 was highly expressed and positively correlated with the clinicopathological characteristics of colorectal cancer tissues. Functional experiments indicated that IPO5 could promote the development of CRC. Mechanistically, we screened RASAL2, one cargo of IPO5, and further confirmed that IPO5 bound to the NLS sequence of RASAL2, mediating RASAL2 nuclear translocation and inducing RAS signal activation, thereby promoting the progression of CRC. CONCLUSIONS: Together, our results indicate that IPO5 is overexpressed in colorectal cancer cells. By transporting RASAL2, IPO5 may play a crucial role in CRC.

12.
Adv Mater ; 31(35): e1902955, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31268581

RESUMO

The next generation of flexible electronics will require highly stretchable and transparent electrodes, many of which consist of a relatively stiff metal network (or carbon materials) and an underlying soft substrate. Typically, such a stiff-soft bilayer suffers from wrinkling or folding when subjected to strains, causing high surface roughness and seriously deteriorated optical transparency. In this work, a network with a giant effective Poisson's ratio on a soft substrate is found to be under biaxial tension upon deformation, and thus does not wrinkle or fold, but maintains smooth surfaces and high transparency. Soft tactile sensors employing such network electrodes exhibit high transparency and low fatigue over many stretching cycles. Such a giant Poisson's ratio has the same effect in other systems. This work offers a new understanding of surface instabilities and a general strategy to prevent them not only in flexible electronics, but also in other materials and mechanical structures that require flat surfaces.

13.
Carbohydr Polym ; 211: 118-123, 2019 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-30824071

RESUMO

TEMPO-mediated oxidation has been successfully used to prepare carboxylated chitin nanofibers (ChNFs) with purified chitins originating from the outer shells of crab and shrimp (α-form) or tubeworm (ß-form). However, the method for obtaining carboxylated ChNFs with squid pen chitin (hydrated ß-form) has not been developed yet. It might be due to the existence of the small amount of partial deacetylation (DD ≈ 9%) in the squid pen ß-chitins. Herein, ultrafine (2-4 nm in width and several micrometers in length) and carboxylated ß-ChNFs were fabricated directly from the squid pen with simultaneously removing of protein, CaCO3 and other non-chitin components by one-step oxidation procedure using ammonium persulfate (APS) and followed ultrasonic disintegration under acid conditions. When 45 wt% APS was used to react with squid pen, the carboxylate content of ChNFs reaches 0.802 mmol/g. Therefore, the ß-ChNFs with anionically charged groups (COO-) can be dispersed stably in aqueous solution under basic conditions. Meanwhile, thus-obtained ß-ChNFs aqueous solution even with very low concentration (0.8%) can be transformed to transparent, robust and moldable hydrogels by gas coagulation of acetic acid.

14.
Artigo em Inglês | MEDLINE | ID: mdl-30887309

RESUMO

The effects of fructose on plantaricin Q7 biosynthesis in Lactobacillus plantarum (L. plantarum) Q7 were investigated. Fructose induced and accelerated plantaricin Q7 production in the early stages of biosynthesis. Two-dimensional electrophoresis and quantitative real-time reverse transcriptase PCR (qRT-PCR) revealed that shock-related proteins were overexpressed in L. plantarum grown in MRS-fructose compared with cultures grown in MRS broth. A preheat-shock (PHS) treatment was used to overexpress shock-related proteins to enhance plantaricin Q7 production. The final plantaricin Q7 level reached 2873.08 IU/mL following PHS treatment, which was 23.36% higher than that obtained using a control strategy without PHS treatment. qRT-PCR analyses indicated that only groL was induced (by 10-fold) following PHS treatment. Evidently, groL plays a critical role in plantaricin Q7 biosynthesis. These results demonstrate that PHS treatment is an efficient approach to improving plantaricin Q7 production. The information obtained in this study may increase the amount of efficient antimicrobial peptide production using L. plantarum.

15.
PLoS One ; 14(3): e0213977, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30925150

RESUMO

Computational modeling of engineered gene circuits is an important while challenged task in systems biology. In order to describe and predict the response behaviors of genetic circuits using reliable model parameters, this paper applies an optimal experimental design(OED) method to obtain input signals. In order to obtain informative observations, this study focuses on maximizing Fisher information matrix(FIM)-based optimal criteria and to provide optimal inputs. Furthermore, this paper designs a two-stage optimization with the modified E-optimal criteria and applies harmony search(HS)-based OED algorithm to minimize estimation errors. The proposed optimal identification methodology involves estimation errors and the sample size to pursue a trade-off between estimation accuracy and measurement cost in modeling gene networks. The designed cost function takes two major factors into account, in which experimental costs are proportional to the number of time points. Experiments select two types of synthetic genetic networks to validate the effectiveness of the proposed HS-OED approach. Identification outcomes and analysis indicate the proposed HS-OED method outperforms two candidate OED approaches, with reduced computational effort.

16.
ACS Appl Mater Interfaces ; 11(10): 10373-10379, 2019 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-30781948

RESUMO

Skin-like electronics require materials that are conducting, soft, intrinsically stretchable, and highly robust. However, electronic devices often consist of multilayers, and the failure of the electronic devices mostly starts from the debonding of the layers because of poor interfacial adhesion and large mechanical mismatch. Herein, we introduce a fully organic and intrinsically stretchable electrode that achieves high robustness by grafting the substrate to improve the interfacial adhesion and by introducing deep folds and wrinkles to improve the stretchability. The electrode exhibits a sheet resistance of 90 Ω/□ and negligible change in resistance at strains of up to 100% and shows no fatigue over 10 000 cyclic stretches to 100% strain. An iontronic skin with the electrodes is capable of detecting tiny objects exemplified by walking ants or fruit flies weighing less than 1 mg, and the device can be cyclically stretched to 30% for 1000 times without fatigue. The high robustness and stretchability of the fully organic iontronic skin lie in the wrinkle structures, small mechanical mismatch, and high interfacial strength among different layers. This work offers a general way to fabricate highly stretchable and robust devices.

17.
BMC Infect Dis ; 19(1): 108, 2019 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-30717679

RESUMO

BACKGROUND: For definitive diagnosis of cryptococcal meningitis, Cryptococcus neoformans and/or C. gattii must be identified within cerebral spinal fluid from the patients. The traditional methods for detecting Cryptococcus spp. such as India ink staining and culture are not ideal. Although sensitive and specific enough, detection of cryptococcal antigen polysaccharide has a high dose hook effect. Therefore, the aim of this study was to introduce a new rapid and simple detection method of Cryptococcus neoformans and C. gattii in cerebral spinal fluid. METHODS: The lateral flow strips combined with recombinase polymerase amplification (LF-RPA) assay was constructed to detect the specific DNA sequences of C. neoformans and C. gattii. The detection limit was evaluated using serial dilutions of C. neoformans and C. gattii genomic DNA. The specificity was assessed by excessive amount of other pathogens genomic DNA. The optimal detection time and amplification temperature were also analyzed. The diagnostic parameters were first calculated using 114 clinical specimens and then compared with that of other diagnostic method. A brief analysis and comparison of different DNA extraction methods was discussed, too. RESULTS: The LF-RPA assay could detect 0.64 pg of genomic DNA of C. neoformans per reaction within 10 min and was highly specific for Cryptococcus spp.. The system could work well at a wide range of temperature from 25 to 45 °C. The overall sensitivity and specificity were 95.2 and 95.8% respectively. As amplification template for LF-RPA assay, both cell lysates and genomic DNA produce similar experimental results. CONCLUSIONS: The LF-RPA system described here is shown to be a sensitive and specific method for the visible, rapid, and accurate detection of Cryptococcus spp. in cerebral spinal fluid and might be useful for clinical preliminary screening of cryptococcal meningitis.


Assuntos
Criptococose/diagnóstico , Cryptococcus gattii/isolamento & purificação , Cryptococcus neoformans/isolamento & purificação , Meningite Criptocócica/diagnóstico , Reação em Cadeia da Polimerase/métodos , RNA Fúngico/líquido cefalorraquidiano , Antígenos de Fungos/líquido cefalorraquidiano , Antígenos de Fungos/genética , Criptococose/líquido cefalorraquidiano , Cryptococcus gattii/genética , Cryptococcus neoformans/genética , Primers do DNA/genética , Diagnóstico Precoce , Humanos , Limite de Detecção , Meningite Criptocócica/líquido cefalorraquidiano , Técnicas Analíticas Microfluídicas/métodos , RNA Fúngico/análise , Recombinases/genética , Sensibilidade e Especificidade , Temperatura Ambiente
18.
ACS Nano ; 13(2): 1097-1106, 2019 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-30633498

RESUMO

Polymers with superior mechanical properties are desirable in many applications. In this work, polyethylene (PE) films reinforced with exfoliated thermally reduced graphene oxide (TrGO) fabricated using a roll-to-roll hot-drawing process are shown to have outstanding mechanical properties. The specific ultimate tensile strength and Young's modulus of PE/TrGO films increased monotonically with the drawing ratio and TrGO filler fraction, reaching up to 3.2 ± 0.5 and 109.3 ± 12.7 GPa, respectively, with a drawing ratio of 60× and a very low TrGO weight fraction of 1%. These values represent by far the highest reported to date for a polymer/graphene composite. Experimental characterizations indicate that as the polymer films are drawn, TrGO fillers are exfoliated, which is further confirmed by molecular dynamics (MD) simulations. Exfoliation increases the specific area of the TrGO fillers in contact with the PE matrix molecules. Molecular dynamics simulations show that the PE-TrGO interaction is stronger than the PE-PE intermolecular van der Waals interaction, which enhances load transfer from PE to TrGO and leverages the ultrahigh mechanical properties of TrGO.

19.
Carbohydr Polym ; 207: 555-562, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30600039

RESUMO

Chitin nanofibers (ChNFs) have emerged as a rising nanomaterial due to their excellent mechanical properties, biocompatibility and biodegradability etc. Herein, carbonylated ChNFs (C-ChNFs) and zwitterionic ChNFs (NC-ChNFs) decorated with both amino (-NH2) and carboxyl (-COOH) groups were used to prepare ChNFs/natural rubber (NR) nanocomposite films by dip molding method, respectively. The results showed that C-ChNFs had better dispersion than that of NC-ChNFs in NRL matrix. Moreover, C-ChNFs/NR nanocomposite films demonstrated obvious pH-responsiveness owing to the association and disassociation of the hydrogen bonding between C-ChNFs under various pH conditions. In contrast, NC-ChNFs/NR nanocomposite films showed pH-stable mechanical properties because the protonation of -NH2 at pH < 7 and the ionization of -COOH at pH > 7 resulted in electrostatic repulsive force between NC-ChNFs. This study demonstrates that surface chemistry of ChNFs plays an important role on tailoring the performance of ChNFs/NRL nanocomposites.

20.
ACS Appl Mater Interfaces ; 11(1): 1303-1310, 2019 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-30525407

RESUMO

Graphene aerogel (GA) has attracted great attention due to its unique properties, such as ultralow density, superelasticity, and multifunctionality. However, it is a great challenge to develop superelastic and fatigue-resistant GA (SFGA) with ultralow density because it is generally contradictory to improve the mechanical properties with reducing density of GA. Herein, we report a simple and efficient approach to prepare ultralight SFGA templated by graphene oxide liquid crystal (GOLC) stabilized air bubbles. The thus-prepared ultralight SFGA (∼2 mg cm-3) exhibits superelasticity (rapid recovery from >99% compression) and unprecedented fatigue-resistant performance (maintaining shape integrity after 106 compressive cycles at 70% strain and 5 Hz). The ultralow density and excellent dynamic mechanical properties of SFGA are mainly associated with the "volume exclusion effect" of the air bubbles as well as the highly ordered, closely packed, and uniform porous structure of the resultant GA, respectively. This study provides a green and facile strategy for preparing high-performance ultralight SFGA, which has great potential in various applications, including ultrafast dynamic pressure sensors, soft robot, and flexible devices.

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