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1.
J Colloid Interface Sci ; 606(Pt 2): 1745-1757, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34500172

RESUMO

Herein, the optional and controllable growth of Bi2S3 onto NH2-MIL-125 via covalent conjunction strategy was reported. The experimental results demonstrate that the obtained heterojunction exhibits boosting photocatalytic reduction CO2 and organic dye degradation. The 18-Bi2S3@NH2-MIL-125-SH displays the highest yield of 12.46 µmol g-1h-1 of CO, >13 times that of pure NH2-MIL-125. Meanwhile, the reaction kinetic of 18-Bi2S3@NH2-MIL-125-SH in the degradation of methylene blue is uppermost, which is 160 times than that of the commercial P25. The enhancement of photocatalytic performance could be ascribed to the covalent coordination-driven intimate interfacial interaction in n-scheme heterojunction. Meanwhile, the plausible mechanism was also investigated by UV-vis diffuse reflectance (UV-vis), photoluminescence (PL), electrochemical photocurrent, electron spin resonance (ESR) and electrochemical impedance spectroscopy (EIS).


Assuntos
Dióxido de Carbono , Titânio , Catálise , Luz , Dietilamida do Ácido Lisérgico/análogos & derivados
2.
Int J Infect Dis ; 2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34781005

RESUMO

AIMS: A high proportion of all tuberculosis (TB) cases present with extrapulmonary tuberculosis (EPTB), including concurrent EPTB involving more than one extrapulmonary lesion site within the body. However, previous reports only characterised lesions of single-site EPTB cases. This study aimed to investigate epidemiological characteristics and association rules of concurrent EPTB cases in China. METHODS: An observational multi-centre study was carried out in China from Jan 2011 to Dec 2017 that included a total of 208,214 patients with EPTB lesions. Multivariable logistic regression analysis was used to identify associations between gender and age with concurrent EPTB. Association rules were analysed for significance using the Apriori algorithm. RESULTS: The most prevalent form of EPTB lesion was tuberculous pleurisy (49.8%), followed by bronchial tuberculosis (14.8%) and tuberculous meningitis (7.6%). The most predominant concurrent EPTB case type was tuberculous pleurisy concurrent with tuberculous peritonitis (1.80%). Altogether 22 association rules were identified that included 20 strong association rules, among which highest confidence rates were found for tuberculous myelitis concurrent with tuberculous meningitis and sacral TB concurrent with lumbar vertebral TB. Moreover, association rules of EPTB concurrent with other EPTB types were found to vary with gender and age. The confidence rate of tuberculous myelitis concurrent with tuberculous meningitis was higher in females (83.67%) than males and highest in patients of ages 25-34 years (87.50%). CONCLUSIONS: Many types of concurrent EPTB were found. Thus, greater awareness of concurrent EPTB disease characteristics is needed to ensure timely clinical diagnosis and treatment of this disease.

3.
Front Chem ; 9: 775274, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34778220

RESUMO

Subarachnoid hemorrhage (SAH) is a fatal disease. Within 72 h of SAH, the intracranial blood-brain barrier (BBB) is destroyed, and the nerve cells have responses such as autophagy, apoptosis, and oxidative stress. Antioxidation is an essential treatment of SAH. Astaxanthin (ATX) induces cells' antioxidant behaviors by regulating related signal pathways to reduce the damage of brain oxidative stress, inflammation, and apoptosis. Because of its easy degradability and low bioavailability, ATX is mainly encapsulated with stimulus-responsive nanocarriers to improve its stability, making it rapidly release in the brain and efficiently enter the lesion tissue. In this study, the ultrasonic cavitation agent perfluorocarbon (PFH), ATX, and fluorescent dye IR780 were loaded with polydopamine (PDA) to prepare a US triggered release nanoparticles (AUT NPs). The core-shell structure of AUT NPs formed a physical barrier to improve the bioavailability of ATX. AUT NPs have high ATX loading capacity and US responsiveness. The experimental results show that the AUT NPs have high stability in the physiological environment. Both US and pH stimuli can trigger the release. Under US, PFH breaks through the rigid shell. The structure of AUT NPs is destroyed in situ, releasing the loaded drugs into neuronal cells to realize the antioxidant and antiapoptotic effects. The in vivo experiment results show that the AUT NPs have good biosafety. They release the drugs in the brain under stimuli. The in vivo treatment results also show that AUT NPs have an excellent therapeutic effect. This approach presents an experimental basis for the establishment of Innovative SAH treatments.

4.
Artigo em Inglês | MEDLINE | ID: mdl-34801238

RESUMO

CsPbBr3 quantum dots (CPB QDs) have great potential in photoreduction of CO2 to chemical fuels. However, the low charge transportation efficiency and chemical instability of CPB QDs presents a considerable challenge. Herein, we describe the electrostatic assemblies of negatively charged colloidal two dimensional (2D) Cu-Tetrakis(4-carboxyphenyl) porphyrins (Cu-TCPP) nanosheets and positively CPB QDs to construct the hydride heterojunction. The photogenerated electron migration from CPB QDs to Cu-TCPP nanosheets has been witnessed, providing the supply of long-lived electrons for the reduction of CO2 molecules adsorbed on Cu-TCPP matrix. As a direct result, The CPB@Cu-TCPP-x (x wt% of CPB QDs) photocatalysts exhibit significantly enhanced photocatalytic conversion of CO2, compared to the parent Cu-TCPP nanosheets or single CPB QDs. Especially, when with 20% CPB QDs, the heterostruture system achieves an evolution yield of 287.08 µmol g-1 in 4 h with highly CO selectivity (99%) under visible light irradiation, which is equivalent to a 3.87-fold improvement compared to the pristine CPB QDs. Meanwhile, the CH4 generation rate can be up to 3.25 µmol g-1. This optimized construction of heterostructure could provide a platform to funnel photoinduced electrons to the reaction center, which can both act as a crucial capture and the reaction actives of CO2.

5.
Technol Cancer Res Treat ; 20: 15330338211049903, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34761720

RESUMO

Background: Lipid metabolism disorders play a key role in the pathogenesis of squamous cell carcinoma (SqCC). Herein we used lipidomics to study the tissue lipid profiles of 40 patients with SqCC. Methods: Lipidomics, based on ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry, was applied to identify altered lipid metabolites between tumor and adjacent noninvolved tissues (ANIT), and partial least squares-discriminant analysis model facilitated the identification of differentially abundant lipids. The area under the receiver operator characteristic curve and variable importance in projection scores of the aforementioned model were calculated to select lipid profiles. Metabolic pathway analyses were completed using Kyoto Encyclopedia of Genes and Genomes and MetaboAnalyst. Results: Differences in lipid profiles were found between tumor and ANIT, early- and advanced-stage SqCC, and positive and negative lymph node metastases. The lipid profile panel was composed of five lipids-PC(44:4), diacylglycerol(36:5), sphingomyelin(d18:1/20:0), phosphatidylinositol(46:7), and HexCer-AP(t8:0/32:2 + O)-and could effectively differentiate between tumor and ANIT. Further, pathway analyses revealed alterations in several lipid metabolism pathways, including glycerophospholipid metabolism, glycosylphosphatidylinositol anchor biosynthesis, linoleic acid metabolism, glycerolipid metabolism, and sphingolipid metabolism. Conclusion: Our data revealed several changes in the tissue lipid profiles of patients with SqCC; moreover, we identified a lipid profile panel that could effectually distinguish tumor tissues from ANIT. We believe that our results provide new insights into the biological behavior of lung SqCC.

6.
Trials ; 22(1): 743, 2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34702311

RESUMO

BACKGROUND: The prevalence of renal calculi in patients with gout is high. Alkalized urine has been recommended by the 2020 European Association of Urology (EAU) guidelines to promote calculus dissolution. However, randomized controlled trials are lacking. METHODS: In the protocol of this randomized, placebo-controlled, double-blinded trial, patients with gout combined with renal calculi are randomized (1:1) to the placebo and sodium bicarbonate groups. The intervention would be performed for 24 weeks, the 1-12 weeks are double-blinded, and the 13-24 weeks are open-labeled. Sodium bicarbonate (1 g tid) will be performed for 24 weeks in the sodium bicarbonate group. The placebo will be performed for 12 weeks and not be performed from 13 weeks to 24 weeks in the placebo group. All subjects will be administered febuxostat (40 mg/day) for 24 weeks and receive concomitant anti-inflammatory prophylaxis therapy for 12 weeks. The primary outcome is the proportion of patients whose renal calculus volume will be reduced after 12 weeks of treatment. The secondary outcomes include the volume changes of renal calculi, uric acid changes, the proportion of patients with serum uric acid (sUA) levels < 360 µmol/L, the changes in estimated glomerular filtration rate (eGFR), the pH value of urine, and the incidence of adverse events after treatment for 12 and 24 weeks. DISCUSSION: This study will evaluate the efficacy and safety of sodium bicarbonate-alkalized urine on renal calculi in patients with gout. TRIAL REGISTRATION: ClinicalTrials.gov ChiCTR2100045183. Registered on April 7, 2021, with ChiCTR.


Assuntos
Gota , Cálculos Renais , Método Duplo-Cego , Febuxostat/uso terapêutico , Gota/diagnóstico , Gota/tratamento farmacológico , Supressores da Gota/uso terapêutico , Humanos , Cálculos Renais/diagnóstico , Cálculos Renais/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento , Ácido Úrico
7.
Artigo em Chinês | MEDLINE | ID: mdl-34670356

RESUMO

Anaplastic lymphoma kinase (ALK) fusion gene, as a tumor driver gene, was crucial for the occurrence and development of non-small cell lung cancer (NSCLC). Recently, targeted ALK fusion gene has become the main treatment method for ALK-positive NSCLC. The first and second generation ALK inhibitors (ALKi), such as crizotinib, ceritinib, alectinib and ensartinib have been approved in China. However, there was no guidance for the management of ALKi adverse reactions. Therefore, this "Recommendations from experts in the management of adverse reactions to ALK inhibitors (2021 version)" has been summarized, led by Lung Cancer Professional Committee of Sichuan Cancer Society and Sichuan Medical Quality Control Center for Tumor Diseases, to provide practical and feasible strategies for clinical ALKi management specification of adverse reactions.
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8.
Sci Rep ; 11(1): 18023, 2021 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-34504296

RESUMO

Similar to global trends, the incidence rate of tuberculosis (TB) in China declined from 2000 to 2018. In this study, we aimed to evaluate TB trends in northern Guizhou Province and identify risk factors associated with rifampicin-resistant (RR) and concurrent extrapulmonary TB (EPTB). We analyzed data of TB patients hospitalized in Affiliated Hospital of Zunyi Medical University from 2011 to 2018, and assessed correlations between demographic characteristics of patients and RR-TB as well as concurrent EPTB. Our results showed that numbers of new, retreated, RR-TB and concurrent EPTB cases increased gradually from 2011 to 2018. Retreated patients had the highest odds of RR-TB but a lower likelihood of concurrent EPTB compared to new patients. Patients between 21 and 40 years of age had a higher likelihood of RR-TB compared to those 20 years and younger. Female patients and patients from Bijie city as well as the Miao ethnic minority had higher odds of concurrent EPTB. In summary, our data demonstrate upward trends in new, rifampicin-resistant and concurrent extrapulmonary TB cases in northern Guizhou Province of China, which should not be overlooked especially during and post the COVID-19 pandemic because TB is a greater long-term global health threat than COVID-19.


Assuntos
Antibióticos Antituberculose/uso terapêutico , Mycobacterium tuberculosis/efeitos dos fármacos , Rifampina/uso terapêutico , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , China/epidemiologia , Farmacorresistência Bacteriana Múltipla/fisiologia , Sistemas Especialistas , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/isolamento & purificação , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
9.
Environ Monit Assess ; 193(9): 576, 2021 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-34392439

RESUMO

Underground coal mining leads to land subsidence, and the situation is particularly serious in the Coal-Grain Complex in eastern China, causing the crop production to be reduced or to be taken out. Backfilling with Yellow River sediment is one of the effective methods to solve the land subsidence in this area, but a key issue is how to select the optimal soil reconstruction profile so that the crop yield after backfilling and reclamation is unaffected. The main purpose of this study is to verify the feasibility of selecting the optimal soil reconstruction profile by rapid monitoring of crop growth and judging soil quality with the aid of unmanned aerial vehicle systems (UAVs). A control treatment and 13 experimental treatments were established for the study area. The control treatment consisted of using 30 cm topsoil and 90 cm subsoil and the topsoil is a proxy for native (undisturbed) soil from the study sites. All other treatments consisted of using varying combinations of subsoil and sediment overlain by 30 cm of topsoil. The vegetation indices from the UAV multispectral images, and the plant height and vegetation coverage from the UAV RGB images were used for estimation of the winter wheat biomass in a random forest regression. The results showed that the random forest regression model yielded accurate estimation of the aboveground biomass. Furthermore, knowledge of plant height and vegetation coverage improved the accuracy of prediction such that crop growth was well characterized. The optimal soil profile consisted of 0.3 m topsoil + 0.2 m subsoil + 0.2 m sediment + 0.2 m subsoil + 0.3 m sediment. A fast and effective airborne monitoring method for soil quality was established, thus providing greatly improved monitoring efficiency.


Assuntos
Minas de Carvão , Solo , Biomassa , Monitoramento Ambiental , Rios , Triticum
10.
Chem Asian J ; 16(20): 3213-3220, 2021 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-34411452

RESUMO

Electrocatalysts have been developed to improve the efficiency of gas release for oxygen evolution reaction (OER), and finding a simple and efficient method for efficient electrocatalysts has inspired research enthusiasm. Herein, we report bimetallic metal-organic gels derived from phytic acid (PA) and mixed transition metal ions to explore their performance in electrocatalytic oxygen evolution reaction. PA is a natural phosphorus-rich organic compound, which can be obtained from plant seeds and grains. PA reacts with bimetallic ions (Fe3+ and Co2+ ) in a facile one-pot synthesis under mild conditions to form PA-FeCo bimetallic gels, and the corresponding aerogels are further partially reduced with NaBH4 to improve the electrocatalytic activity. Mixed valence states of Fe(II)/Fe(III) and Co(III)/Co(II) are present in the materials. Excellent OER performance in terms of overpotential (257 mV at 20 mA cm-2 ) and Tafel slope (36 mV dec-1 ) is achieved in an alkaline electrolyte. This reduction method is superior to the pyrolysis method by well maintaining the gel morphology structure. This strategy is conducive to the further improvement of the performance of metal-organic electrocatalysts, and provides guidance for the subsequent application of metal-organic gel electrocatalysts.

11.
Orphanet J Rare Dis ; 16(1): 327, 2021 07 22.
Artigo em Inglês | MEDLINE | ID: mdl-34294091

RESUMO

BACKGROUND: There are over 16.8 million rare disease patients in China, representing a large community that should not be neglected. While the public lack the awareness of their existence and difficult status quo, for one reason that they exist as a rare and special group in our society, for another reason that all sectors of the community haven't introduced and propagandized them suitably. However, as a special group with more difficulties in all aspects than normal healthy persons, they need enough care and love from us. To provide a basis for policy-makers to better understand the status quo of rare disease patients and care-givers in China and to devise some new policies to improve their quality of life, a comprehensive analysis of the status quo, unmet needs, difficulty caused by the rare disease is essential. METHODS: A questionnaire-based online study of patients and care-givers (usually family members) was performed. The questionnaire was composed of 116 questions, such as the diagnosis process, treatment access, financial burden, views on patients' organizations, and a series of standardized tests to assess the quality of their life, including the SF-36, PHQ-9, PHQ-15, GAD-7, and PSQI. To examine the influence of age, disease type, and relationship to patients on the scores in these tests, statistical analysis with a general linear model was conducted. FINDINGS: A total of 1959 patients and care-givers participated in the survey, representing 104 rare diseases, such as lysosomal storage diseases, hemophilia, and muscular dystrophy diseases. The diagnosis was delayed for 1.4 ± 3.0 years, and patients experienced 1.6 ± 3.8 misdiagnoses between 3.2 ± 2.4 hospitals. The hospitals where diagnoses were made were highly concentrated in 10 large hospitals (43.8%) and 5 big cities (42.1%), indicating a significant inequality of medical resources. The disease often led to difficulty in social life, education, and employment, as well as financial burden that was seldom covered by medical insurance. A battery of standardized tests demonstrated poor health status, depression, somatization, anxiety, and sleeping issues among both patients and care-givers (p < 0.05). Statistical analysis of the questionnaire also showed that poor health, anxiety, depression, somatization, and sleeping problems were more prevalent in patients than in care-givers, and more prevalent in more severe diseases (e.g., hemophilia, Dravet) or undiagnosed than in other diseases. INTERPRETATIONS: This study identified the lack of rare disease awareness and legislative support as the major challenge to rare diseases in China, and makes key recommendations for policy-makers, including legislating orphan drug act, raising rare disease awareness, providing sufficient and fair opportunities about education and employment, expanding the medical insurance coverage of treatments, and protecting rights in education and employment.


Assuntos
Qualidade de Vida , Doenças Raras , China , Humanos , Produção de Droga sem Interesse Comercial , Inquéritos e Questionários
12.
Opt Lett ; 46(15): 3753-3756, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-34329273

RESUMO

This Letter presents a novel, to the best of our knowledge, linearized analog photonic link (APL) based on a phase-coherent orthogonal light wave generator that consists of a polarization-dependent Mach-Zehnder modulator (MZM) and a polarization controller (PC). By adjusting the PC and bias voltage of MZM, the third-order intermodulation (IMD3) terms can be suppressed while retaining a high gain for the fundamental terms, which indicates that the spurious free dynamic range (SFDR) of the proposed APL can be much improved. To further verify the feasibility of the proposed APL, a proof-of-concept experiment is performed, and the performances are compared with conventional APL. The experimental results demonstrate that a 14 dB improvement in the fundamental to IMD3 power ratio and an SFDR of 100.2dB⋅Hz2/3 or 119.1dB⋅Hz2/3 for a noise floor of -139dBm/Hz or -163.9dBm/Hz are achieved. In addition, an orthogonal frequency division multiplexing signal with 30 MHz bandwidth centered at 2.5 GHz is delivered by our proposed APL, whose signal-to-noise ratio is increased by 10 dB, compared to conventional APL.

13.
Cancer Commun (Lond) ; 41(9): 889-903, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34184418

RESUMO

BACKGROUND: Previous studies have demonstrated the preclinical pharmacological and toxicological consistency, and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab (Avastin). This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC). METHODS: Stage IIIB-IV NSCLC patients with evaluable lesions, good physical status, and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin (combined treatment) for 4-6 cycles, followed by maintenance monotherapy with LY01008 until disease progression, intolerable toxicity, or death. The primary endpoint was objective response rate (ORR) in accordance with Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 confirmed by independent radiological review committees (IRRC). Secondary endpoints included disease control rate (DCR), duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety. This study was registered in ClinicalTrials.gov (NCT03533127). RESULTS: Between December 15th , 2017, and May 15th , 2019, a total of 649 patients were randomized to the LY01008 (n = 324) or Avastin (n = 325) group. As of September 25th , 2019 for primary endpoint analysis, 589 patients received ORR evaluation, with a median number of combined treatment cycles of 5 (range 1-6) and median duration of treatment of 3.0 (range 0.0-5.1) months. ORR of response-evaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%, respectively. The stratified ORR ratio was 0.91 (90% CI 0.80-1.04, within the prespecified equivalence margin of 0.75-1.33). Up to May 15th , 2020, with a median follow-up of 13.6 (range 0.8-28.4) months, no notable differences in DCR, median DoR, median PFS, median OS, and 1-year OS rate were observed between the LY01008 and Avastin groups. There were no clinically meaningful differences in safety and immunogenicity across treatment groups. CONCLUSIONS: LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC. LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable, metastatic, or recurrent non-squamous NSCLC patients in the first-line setting.


Assuntos
Medicamentos Biossimilares , Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Bevacizumab/efeitos adversos , Medicamentos Biossimilares/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , China , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Resultado do Tratamento
14.
Biomed Chromatogr ; 35(10): e5172, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33982312

RESUMO

A sensitive gas chromatography-mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During the experiment, rats were randomly divided into two groups (low, high) and were administered aqueous extract of Mylabris compound for 7 days. Then, plasma and tissue samples were taken at different time points to study the pharmacokinetics and tissue distribution of CTD in rats. The selected reaction monitoring transitions for CTD and clofibrate (internal standard) were m/z 128 → 85 and m/z 169 → 141, respectively. The calibration curve ranged from 10.26 to 3,078 ng/ml for plasma and from 10.26 to 246.24 ng/ml for liver homogenates. The lower limits of quantification were 10.26 ng/ml for both plasma and liver. The intra- and inter-day precision and accuracy were <20% for both plasma and liver homogenates. Extraction recovery ranged from 89.21 to 103.61% for CTD in rat plasma and liver and from 83.79 to 102.74% for IS in rat plasma and liver. Matrix effects ranged from 93.06 to 110.44% for CTD and from 91.65 to 110.80% for IS.


Assuntos
Produtos Biológicos , Cantaridina , Besouros , Administração Oral , Animais , Produtos Biológicos/administração & dosagem , Produtos Biológicos/farmacocinética , Cantaridina/análise , Cantaridina/química , Cantaridina/farmacocinética , Feminino , Cromatografia Gasosa-Espectrometria de Massas/métodos , Masculino , Medicina Tradicional Chinesa , Ratos , Ratos Sprague-Dawley , Distribuição Tecidual
15.
Artigo em Inglês | MEDLINE | ID: mdl-34055017

RESUMO

Purpose: Compound banmao capsule (CBC), a well-known traditional Chinese medical material, is known to inhibit various tumors. However, its material basis and pharmacological mechanisms remain to be elucidated. This study aimed to investigate the effective material basis and mechanisms of action of CBC against tumors. Methods: Active compounds of CBC were identified using public database and reports to build a network. The corresponding targets of active compounds were retrieved from online databases, and the antitumor targets were identified by GeneCards database. The antitumor hub targets were generated via protein-protein interaction analysis using String, and key compounds and targets from the integrative network were detected by molecular docking and ADMET. Top targets in hepatocellular carcinoma were confirmed by quantitative real-time PCR (qPCR). Finally, the multivariate biological network was built to identify the integrating mechanisms of action of CBC against tumor cells. Results: A total of 128 compounds and 436 targets of CBC were identified successfully. Based on the generated multivariate biological network analysis, 25 key compounds, nine hub targets, and two pathways were further explored. Effective material bases of cantharidin, baicalein, scutellarin, sesamin, and quercetin were verified by integrative network analysis. PTGS2, ESR1, and TP53 were identified as hub targets via multivariate biological network analysis and confirmed using qPCR. Furthermore, VEGF and estrogen signaling pathways seem to play a role in the antitumor activity of CBC. Thus, breast cancer may be a potential clinical indication of CBC. Conclusion: This study successfully identified the material basis of CBC and its synergistic mechanisms of action against tumor cells.

16.
Chemistry ; 27(34): 8791-8798, 2021 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-33830549

RESUMO

A catalogue of metal-organic gels are synthesized from phytic acid (PA) and a diversity of metal ions (Fe3+ , Cr3+ , Al3+ , Ce3+ , Y3+ , Co2+ , Ni2+ , Mn2+ , Cu2+ , Zn2+ , Mg2+ ) upon heating at 80 °C. PA-M gels have various morphologies, including irregular granular (PA-Fe, PA-Al, PA-Ce, PA-Cr, PA-Ni, PA-Co), spongy (PA-Y), and hollow tremella-like (PA-Cu) morphologies. Interestingly for PA-Fe-1 : 4 (PA:Fe3+ =1 : 4) a large amount of gas is generated during the gelation process leading to a self-foaming gel. The PA-Fe-1 : 4 self-foaming gel shows reversible gel-sol phase transition. The gel is unusually weakened and transformed into a sol at room temperature, and the sol is reversed to gelation when heated again at 80 °C. PA-Fe-1 : 4 gel also shows shapeable and load-bearing properties, and it can bear up to 200 times of its weight, depending on the gas amount fixed in the foam gel and the aging time. This work provides a catalogue of self-foaming supramolecular gels with tunable properties based on naturally abundant resources.

17.
Orphanet J Rare Dis ; 16(1): 171, 2021 04 13.
Artigo em Inglês | MEDLINE | ID: mdl-33849615

RESUMO

BACKGROUND: It is estimated that there are over 16.8 million rare disease patients in China, representing a significant challenge for the healthcare system and society. Rare disease patients often experience delayed diagnosis, misdiagnosis, or improper treatment, which may be due to the lack of rare disease awareness among physicians. MATERIALS AND METHODS: A total of 224 physicians from different hospitals in China participated in the questionnaire, and 9 rare disease experts were interviewed with open-ended questions. RESULTS: Most physicians (83.5%) were from Tertiary hospitals, which have over 500 beds. Only 5.3% of physicians were moderately or well aware of rare diseases. Most physicians (80.1%) had suspected their patients to have rare diseases less than 3 times. There was a strong support for special legislations for rare diseases and orphan drugs. Further, multinomial logistic regression (MLR) was used to determine whether hospitals, gender, and career length has an impact on perspectives and awareness. It was shown that male physicians were more likely to think newborn screening is important (p < 0.05). The longer the career length is, the more likely physicians believe that their previous education has not provided sufficient information about rare diseases and that their hospital has paid enough attention to rare diseases. Physicians from Tertiary A hospitals were more likely to rate the affordability of orphan drugs high. In addition, nine experts believed that rare disease awareness is essential for early diagnosis and timely treatment. These experts also made recommendations on how to improve rare disease awareness through medical school education and continuing training. CONCLUSIONS: Our study highlighted the importance of improving rare disease awareness among physicians in China. Recommendations about how to improve rare disease awareness in medical school education and establish an online 'information hub' are made for considerations of policy-makers.


Assuntos
Médicos , Doenças Raras , China , Humanos , Recém-Nascido , Masculino , Produção de Droga sem Interesse Comercial , Doenças Raras/diagnóstico , Inquéritos e Questionários
18.
J Palliat Med ; 24(6): 932-943, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33835877

RESUMO

Background: Fatigue is a frequent debilitating symptom among patients with lung cancer. The effect of exercise on fatigue remains to be quantified. Objective: This review aimed to examine the effect of exercise on fatigue by synthesizing findings from randomized controlled trials (RCTs). Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was conducted in five electronic databases from inception to March 2020. Only RCT was included. The primary outcome was fatigue and the secondary outcomes included depression, anxiety, quality of life, and functional capacity. Pooled weighted or standardized mean difference (WMD or SMD) with 95% confidence interval (CI) was calculated. Results: Eight RCTs were included. The exercise intervention was delivered in the supervised environment (n = 6) or free-living settings (n = 2). Exercise reduced the level of fatigue (SMD = -0.33; 95% CI = -0.54 to -0.13). Exercise also decreased depressive symptom (WMD = -1.57; 95% CI = -2.69 to -0.44) and anxiety (WMD = -1.39; 95% CI = -2.60 to -0.18). Exercise showed a moderate effect on the quality of life, with an SMD of 0.33 (95% CI = 0.08 to 0.58). Exercise intervention increased functional capacity as measured by the six-minute walk test by 20 meters (95% CI = 14.2 to 55.0), but the effect was not significant (p = 0.247). Conclusion: Exercise demonstrated a moderate effect on fatigue in patients with lung cancer. Exercise also improved depressive symptoms, anxiety, and quality of life; however, its impact on functional capacity was not significant. More clinical trials are warranted to explore the mechanisms underlying the impact of exercise on fatigue. Strategies improving adherence to exercise prescription should be developed to help these patients overcome potential challenges.


Assuntos
Fadiga , Neoplasias Pulmonares , Ansiedade , Exercício Físico , Humanos , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto
19.
Langmuir ; 37(18): 5531-5539, 2021 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-33913320

RESUMO

Developing stable gel materials for adsorption and catalysis is one of the major themes of gel materials. However, it has been proven to be challenging to achieve them from small molecules. Herein, an imine gel is developed from tetra-aldehyde 4-{2,2-bis[(4-formylphenoxy)methyl]-3-(4-formylphenoxy)propoxy}benzaldehyde (A4) and 3,3'-dihydroxybenzidine (B2) based on dynamic covalent chemistry. The unstable A4B2-imine gel is further converted into a stable aromatic benzoxazole-linked A4B2-benzoxazole gel via oxidative cyclization, which has significantly improved chemical stability under acidic and basic conditions. Benefiting from the stability under acidic conditions, the A4B2-benzoxazole gel is used for Pd(II) adsorption and the adsorption capacity is 250 mg g-1. After PdCl2 immersion and reduction, palladium nanoparticles with a size distribution of 1.3-14.7 nm are encapsulated by the network structure of the stable porous benzoxazole gel matrix. The Pd@A4B2-benzoxazole gel exhibits high catalytic activity toward the reduction of toxic hexavalent chromium Cr(VI) (reaction rate constant = 0.0377 min-1), while there is no significant decrease in the catalytic efficiency after five cycles.

20.
Rheumatology (Oxford) ; 60(9): 4199-4204, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-33404656

RESUMO

OBJECTIVE: Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode. METHODS: In this randomized, placebo-controlled, single-blinded, multicentre trial, patients with acute gout flares within 72 h were randomized (1:1) to the placebo and febuxostat (40 mg/day) groups. All patients were administered diclofenac (150 mg/day) for 7 days and then open-labelled on the eighth day. Febuxostat 40 mg daily and diclofenac 75 mg daily were administered from day 8 through 28 for the remission period. The dose of diclofenac was 150 mg/day before remission in both arms, and the original protocol was maintained until remission. The primary outcome was 'days to resolution'. RESULTS: We randomized 140 patients, 70 into each arm. The mean days to resolution was 5.98 days [median 7.00, interquartile range (IQR) 2.45 days] for the placebo and 6.50 days (median 7.00, IQR 3.67 days) for the febuxostat group (P = 0.578). The rate of resolution within 7 days was 84.38% for the placebo group and 76.92% for the febuxostat group (P = 0.284). There were no statistically significant differences in joint pain, swelling, tenderness and erythema scores at days 1, 3, 5 and 7. The mean serum uric acid levels were 507.54 and 362.62 µmol/l for the placebo and febuxostat group, respectively, on day 7 (P = 0.000). The rate of recurrent gout flares was 10.00% for the placebo group and 6.56% for the febuxostat group from day 8 through 28 (P = 0.492). CONCLUSION: Initiation of febuxostat administration during an acute gout flare did not prolong the duration of acute flares. TRIAL REGISTRATION: Chinese Clinical Trial Registry, http://www.chictr.org.cn/, ChiCTR1800015962.


Assuntos
Febuxostat/uso terapêutico , Supressores da Gota/uso terapêutico , Gota/tratamento farmacológico , Adulto , Anti-Inflamatórios não Esteroides/uso terapêutico , Diclofenaco/uso terapêutico , Feminino , Gota/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Método Simples-Cego , Exacerbação dos Sintomas , Resultado do Tratamento , Ácido Úrico/sangue
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