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1.
Appl Math Lett ; 125: 107783, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34776608

RESUMO

The 2019 novel coronavirus (COVID-19) emerged at the end of 2019 has a great influence on the health and lives of people all over the world. The spread principle is still unclear. This paper considers a novel evolution model of COVID-19 in terms of an integral-differential equation, involving vaccination effect and the incubation of COVID-19. The proposed mathematical model is rigorously analyzed on its asymptotic behavior with new probability functions, showing the final spread tendency. Moreover, our model is also verified numerically by the practical epidemic data of COVID-19 in Yangzhou from July to August 2021.

2.
Sci Total Environ ; 803: 150018, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34525734

RESUMO

Drought is a complicated and costly natural hazard and identification of critical drought factors is critical for modeling and forecasting of droughts and hence development of drought mitigation measures (the Standardized Precipitation-Evapotranspiration Index) in both space and time. Here we quantified relationships between drought and 23 drought factors using remote sensing data during the period of 2002-2016. Based on the Gradient Boosting Algorithm (GBM), we found that precipitation and soil moisture had relatively large contributions to droughts. During the growing season, the relative importance of Normalized Difference Water Index (NDWI-7) for SPEI3, SPEI6, SPEI9, and SPEI12 reached as high as 50%. However, during the non-growing season, the Snow Cover Fraction (SCF) had larger fractional relative importance for short-term droughts in the Inner Mongolia and the Loess Plateau which can reach as high as 10%. We also compared Extremely Randomized Trees (ERT), H2O-based Deep Learning (Model developed by H2O.deep learning in R H2O.DL), and Extreme Learning Machine (ELM) for drought prediction at various time scales, and found that the ERT model had the highest prediction performance with R2 > 0.72. Based on the Meta-Gaussian model, we quantified the probability of maize yield reduction in the North China Plain under different compound dry-hot conditions. Due to extreme drought and hot conditions, Shandong Province in North China had the highest probability of >80% of the maize yield reduction; due to the extreme hot conditions, Jiangsu Province in East China had the largest probability of >86% of the maize yield reduction.


Assuntos
Secas , Zea mays , China , Estações do Ano , Solo
3.
J Colloid Interface Sci ; 606(Pt 2): 1120-1127, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34487932

RESUMO

Layered double hydroxides (LDHs) have been considered as favorable pseudocapacitive electrode materials for supercapacitors due to their tunable layered structure/compositions and low cost. Here, we report the NiCo-LDH hollow spheres prepared with Co-glycerate as the sacrificial template and cobalt source. The hollow spheres are assembled with frizzy NiCo-LDH nanosheets, where the hollow structure can inhibit agglomeration of the LDH nanosheets to expose more active sites and shorten the diffusion path of electrolyte ions. The prepared NiCo-LDH hollow spheres show a high specific capacitance of 1962 F g-1 at 1 A g-1 and good capacitance retention rate of 66.4 % at 30 A g-1. The asymmetric supercapacitors fabricated using NiCo-LDH hollow spheres as positive electrode yields a large energy density 62.9 Wh kg-1 at the power density of 0.8 kW kg-1. This research may develop a facile synthesis way to prepare LDH hollow spheres for supercapacitors.


Assuntos
Cobalto , Hidróxidos , Capacitância Elétrica , Eletrodos
4.
Chemosphere ; 287(Pt 1): 132110, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34523433

RESUMO

Agricultural soils are major sources of greenhouse gases (GHGs) that related with intensive fertilizer input. Biochar is widely used to mitigate GHGs, which may interact with soil water content impacting GHG emissions. Camellia oleifera fruit shell (FS) and spent mushroom substrate (MS) are ideal biochar feedstocks. However, the impact of water content and biochar on soil GHG emissions has not been thoroughly understood. Here, we examined CH4 and N2O emissions from C. oleifera plantation soils as affected by biochar (derived from MS or FS, 1 g 25 g-1 soil), water content (60%, 120%, 240% or 360% water holding capacity, WHC), and fertilization (control or chicken manure, CM 2.5 g 25 g-1 soil). We determined the abundance of related microbial functional genes to obtain the underlining mechanisms. The results showed that higher N2O emissions occurred in soils with 120%WHC, due to increased abundance of AOA, AOB and nirS. MS or FS biochar differed in their effects on soil GHG emissions with different WHC. MS biochar was higher in pH, C/N and specific surface area, and mitigated more N2O emissions from soils with CM and 120%WHC relative to FS biochar (by 92.9% and 34.6%, respectively). MS biochar significantly decreased abundance of nitrification related functional genes (AOA, AOB) in soils with 120%WHC and CM, which explained the decrease in N2O emissions. However, MS biochar increased cumulative CH4 emissions from flooded soils via increase in mcrA abundance. Thereby, biochar feedstocks should be considered in CH4 and N2O mitigations from soils with different water contents.


Assuntos
Agaricales , Camellia , Carvão Vegetal , Fertilização , Óxido Nitroso/análise , Solo , Água
5.
Sci Total Environ ; 803: 149929, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34478900

RESUMO

Nitrous acid (HONO) is a major source of hydroxyl radicals in the troposphere through its photolysis, and can significantly influence ozone (O3) levels, thereby causing considerable crop yield losses. Previous studies have assessed relative crop yield losses by using exposure-response equations with observed or simulated O3, however, the contribution of enhanced O3 due to potential HONO sources to the crop yield losses has never been quantified. In this study, for the first time, we evaluated the crop yield losses caused by potential HONO sources in the North China Plain (NCP), which is one of the major grain-producing areas in China suffering from heavy O3 pollution, by using the Weather Research and Forecasting/Chemistry (WRF-Chem) model during the wheat and maize growing seasons of 2016. HONO simulations were significantly improved after including six potential HONO sources in the WRF-Chem model. The potential HONO sources produced a daily maximum 8-h O3 enhancement of 8.1/8.2 ppb during the wheat/maize growing seasons, respectively, and led to ~11.4%/3.3% relative yield losses for wheat/maize, respectively, corresponding to approximately US$3.78/0.66 billion losses, respectively, in NCP in 2016. The above results suggest that potential HONO sources play a significant role in O3 formation and could induce high crop yield losses globally.


Assuntos
Poluentes Atmosféricos , Ozônio , Poluentes Atmosféricos/análise , China , Ácido Nitroso , Ozônio/análise , Estações do Ano
6.
New Phytol ; 233(1): 344-359, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34610140

RESUMO

High-temperature stress inhibits normal cellular processes and results in abnormal growth and development in plants. However, the mechanisms by which rice (Oryza sativa) copes with high temperature are not yet fully understood. In this study, we identified a rice high temperature enhanced lesion spots 1 (hes1) mutant, which displayed larger and more dense necrotic spots under high temperature conditions. HES1 encoded a UDP-N-acetylglucosamine pyrophosphorylase, which had UGPase enzymatic activity. RNA sequencing analysis showed that photosystem-related genes were differentially expressed in the hes1 mutant at different temperatures, indicating that HES1 plays essential roles in maintaining chloroplast function. HES1 expression was induced under high temperature conditions. Furthermore, loss-of-function of HES1 affected heat shock factor expression and its mutation exhibited greater vulnerability to high temperature. Several experiments revealed that higher accumulation of reactive oxygen species occurred in the hes1 mutant at high temperature. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and comet experiments indicated that the hes1 underwent more severe DNA damage at high temperature. The determination of chlorophyll content and chloroplast ultrastructure showed that more severe photosystem defects occurred in the hes1 mutant under high temperature conditions. This study reveals that HES1 plays a key role in adaptation to high-temperature stress in rice.

7.
Bioengineered ; 2021 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-34847839

RESUMO

Dysregulation of mitochondrial calcium uniporter (MCU) exerts a carcinogenic effect in several cancers. Nevertheless, the roles of MCU in oral squamous cell carcinoma (OSCC) remain elusive. It has been reported that Dihydroartemisinin (DHA) may suppress the progression of OSCC but its associated mechanisms have been not investigated. The purpose of our research was to observe the biological function of MCU on OSCC and its regulatory relationship with DHA. MCU, MICU1, MICU2, N-cadherin, TGF-ß and Vimentin expression was detected in OSCC and peritumoral tissues by immunohistochemistry and western blot. Following DHA treatment, the expression of above proteins was detected in CAL-27 cells transfected with shMCU or pcDNA3.1-MCU by western blot or immunofluorescence. Furthermore, clone formation, mitochondrial membrane potential (MMP), wound healing and transwell assays were presented in CAL-27 cells treated with DHA, shMCU or pcDNA3.1-MCU. Our results showed that the members of MCU complex including MCU, MICU1 and MICU2 were overexpressed in OSCC compared to peritumoral tissues. Furthermore, TGF-ß and epithelial to mesenchymal transition (EMT) proteins (N-cadherin and Vimentin) exhibited higher expression in OSCC. DHA treatment significantly lowered the expression of MCU in CAL-27 cells. MCU overexpression reversed the inhibitory effects of DHA on MICU1, MICU2, N-cadherin, TGF-ß and Vimentin expression. Furthermore, MCU knockdown or DHA suppressed proliferation, MMP and migration of CAL-27 cells. DHA treatment could reverse the effects of MCU overexpression. Collectively, our study demonstrated that MCU was an oncogene of OSCC and DHA exerted a suppressive role on proliferation and migration of OSCC cells by suppressing MCU expression.

8.
Small ; : e2105661, 2021 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-34854559

RESUMO

Polar oxides are widely used as the cathodes to impede the shuttle effect in lithium-sulfur batteries, but suffer from the sluggish desorption and conversion of polysulfides due to too strong affinity of polysulfides on oxygen sites. Herein, employing halloysite as a model, an approach to overcome these shortcomings is proposed via engineering oxygen p-band center by loading titanium dioxide nanoparticles onto Si-O surface of halloysite. Using density functional theory calculations, it is predicted that electron transfer from titanium dioxide nanoparticles to interfacial O sites results in downshift of p-band center of O sites that promote desorption of polysulfides and the cleavage of Li-S and S-S, accelerating the conversion kinetics of polysulfides. The designed composite cathode material delivers outstanding electrochemical performance in Li-S batteries, outperforming the recently reported similar cathodes. The concept could provide valuable insight into the design of other catalysts for Li-S batteries and beyond.

11.
Front Cell Infect Microbiol ; 11: 781132, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34858883

RESUMO

Hookworm is one type of soil-transmitted helminth, which could exert an anti-inflammatory effect in human or animal host, which provides a beneficial possibility for the discovery of inflammatory-related disease interventions. The identification of hookworm-derived anti-inflammatory molecules is urgently needed for future translational research. The emergence of metabolomics has become a powerful approach to comprehensively characterize metabolic alterations in recent times. Herein, excretory and secretory products (ESPs) were collected from cultured adult worm, while small intestinal contents were obtained from Nippostrongylus brasiliensis (N. brasiliensis, Nb)-infected mice. Through ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) platform, metabolomics analysis was used to explore the identification of anti-inflammatory molecules. Out of 45 differential metabolites that were discovered from ESPs, 10 of them showed potential anti-inflammatory properties, which could be subclassed into amino acids, furanocoumarins, linear diarylheptanoids, gamma butyrolactones, and alpha-keto acids. In terms of intestinal contents that were derived from N. brasiliensis-infected mice, 14 out of 301 differential metabolites were discovered to demonstrate anti-inflammatory effects, with possible subclassification into amino acids, benzylisoquinolines, quaternary ammonium salts, pyrimidines, pregnane steroids, purines, biphenyls, and glycerophosphocholines. Furthermore, nine of the differential metabolites appeared both in ESPs and infected intestinal contents, wherein four were proven to show anti-inflammation properties, namely, L-glutamine, glutamine (Gln), pyruvate, and alanine-Gln (Ala-Gln). In summary, we have provided a method for the identification and analysis of parasite-derived molecules with potential anti-inflammatory properties in the present study. This array of anti-inflammatory metabolites could provide clues for future evaluation and translational study of these anti-inflammatory molecules.

12.
Clin Transl Sci ; 2021 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-34859601

RESUMO

Rivaroxaban is an oral anticoagulant that inhibits thrombin and blocks coagulation cascade through directly inactivating factors Xa. Despite rivaroxaban is widely used for prevention and treatment of venous thrombosis, and its common adverse reactions have been reported, including abnormal coagulation, mucosal hemorrhage, hematuria and intracranial hemorrhage. To explore potential drivers of individual differences in adverse reactions induced by rivaroxaban, we performed whole-exome sequencing and found that AKR7A3 rs1738023/rs1738025 and ABCA6 rs7212506 are susceptible sites for rivaroxaban-related bleeding in aged patients treated with rivaroxaban. Gene functional annotation and signaling pathway enrichment indicated that homozygous mutations in AKR7A3 and ABCA6 might alter normal rivaroxaban transport and metabolism, and lead to continuous accumulation of activated drugs and toxic substances in vivo. Our results suggested that inter-individual differences in bleeding events induced by rivaroxaban may be potentially driven by genetic alterations related to abnormal metabolism and transport of rivaroxaban.

13.
ACS Nano ; 2021 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-34860017

RESUMO

In order to overcome the shuttling effect of soluble polysulfides in lithium-sulfur (Li-S) batteries, we have designed and synthesized a creative MoS2-MoO3/carbon shell (MoS2-MoO3/CS) composite by a H2O2-enabled oxidizing process under mild conditions, which is further used for separator modification. The MoS2-MoO3 heterostructures can conform to the CS morphology, forming two-dimensional nanosheets, and thus shorten the transport path of lithium ion and electrons. Based on our theoretical calculations and experiments, the heterostructures show strong surface affinity toward polysulfides and good catalytic activity to accelerate polysulfide conversion. Benefiting from the above merits, the Li-S battery with a MoS2-MoO3/CS modified separator exhibits good electrochemical performance: it delivers a high discharge capacity of 1531 mAh g-1 at 0.2 C; the initial capacity can be maintained by 92% after 600 cycles at 1 C, and the discharge capacity decay rate is only 0.0135% per cycle. Moreover, the MoS2-MoO3/CS battery still achieves good cycling stability with 78% capacity retention after 100 cycles at 0.2 C with a high sulfur loading of 5.9 mg cm-2. This work offers a facile design to construct the MoS2-MoO3 heterostructures for high-performance Li-S batteries, and may also improve one's understanding on the heterostructure contribution during polysulfide adsorption and conversion.

14.
J Maxillofac Oral Surg ; 20(4): 594-596, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34776691

RESUMO

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world, and it is extremely rare that HNSCC occurs with salivary gland tumor(s). Here, we presented a rare case that squamous cell carcinoma of floor of mouth occurred simultaneously with Warthin's tumor in the submandibular gland. Case Presentation: A 65-year-old Chinese male presented with a 6-month history of an ulcer on the floor of the mouth and preoperative biopsy pathological examination demonstrated it was squamous cell carcinoma. Postoperative microscopic examination unexpectedly found the carcinoma occurred simultaneously with two Warthin's tumors in the right submandibular gland. Conclusion: This case serves as a reminder to oral surgeons that in head and neck carcinomas, enlarged lump may be caused by inflammation or secondary primary focus rather than lymph node metastasis. Recognition and implication of the unexpected pathologic findings in patients with head and neck cancer are thus worth of studying.

15.
Artigo em Inglês | MEDLINE | ID: mdl-34762590

RESUMO

With the advent of the era of massive data, the increase of storage demand has far exceeded current storage capacity. DNA molecules provide a reliable solution for big data storage by virtue of their large capacity, high density, and long-term stability. To reduce errors in storing procedures, constructing a sufficient set of constraint encoding is critical for achieving DNA storage. A new version of the Marine Predator algorithm (called QRSS-MPA is proposed in this paper to increase the lower limit of the coding set while satisfying the specific combination of constraints. In order to demonstrate the effectiveness of the improvement, the classical CEC-05 test function is used to test and compare the mean, variance, scalability, and significance. In terms of storage, the lower limit of construction is compared with previous works, and the result is found to be significantly improved. In order to prevent the emergence of a secondary structure that leads to sequencing failure, we give a more stringent lower bound for the constraint coding set, which is of great significance for reducing the error rate of DNA storage amidst its rapid development.

16.
Molecules ; 26(21)2021 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-34770829

RESUMO

To search for novel androgen receptor (AR) modulators for the potential treatment of castration-resistant prostate cancer (CRPC), naturally occurring silibinin was sought after as a lead compound because it possesses a moderate potency towards AR-positive prostate cancer cells and its chemical scaffold is dissimilar to all currently marketed AR antagonists. On the basis of the structure-activity relationships that we have explored, this study aims to incorporate carbamoyl groups to the alcoholic hydroxyl groups of silibinin to improve its capability in selectively suppressing AR-positive prostate cancer cell proliferation together with water solubility. To this end, a feasible approach was developed to regioselectively introduce a carbamoyl group to the secondary alcoholic hydroxyl group at C-3 without causing the undesired oxidation at C2-C3, providing an avenue for achieving 3-O-carbamoyl-5,7,20-O-trimethylsilybins. The application of the synthetic method can be extended to the synthesis of 3-O-carbamoyl-3',4',5,7-O-tetramethyltaxifolins. The antiproliferative potency of 5,7,20-O-trimethylsilybin and its nine 3-carbamoyl derivatives were assessed in an AR-positive LNCaP prostate cancer cell line and two AR-null prostate cancer cell lines (PC-3 and DU145). Our preliminary bioassay data imply that 5,7,20-O-trimethylsilybin and four 3-O-carbamoyl-5,7,20-O-trimethylsilybins emerge as very promising lead compounds due to the fact that they can selectively suppress AR-positive LNCaP cell proliferation. The IC50 values of these five 5,7,20-O-trimethylsilybins against the LNCaP cells fall into the range of 0.11-0.83 µM, which exhibit up to 660 times greater in vitro antiproliferative potency than silibinin. Our findings suggest that carbamoylated 5,7,20-O-trimethylsilybins could serve as a natural product-based scaffold for new antiandrogens for lethal castration-resistant prostate cancer.

17.
Biomater Sci ; 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34783803

RESUMO

Bacterial infection is one of the most significant public health challenges due to the limited choices of antibiotics which can overcome antibiotic-resistant bacteria. The promising nonantibiotic therapeutic alternatives for antibiotic-resistant bacterial infection are urgently needed to reduce the disease burden. Herein, the water-soluble branched poly(amino ester) with inherently antibacterial (chemotherapy) and enhanced inflammatory response activity (immunotherapy) was prepared via Michael addition polymerization to combat bacterial infection. These polymers can not only damage bacteria walls, leading to the death of bacteria but also activate macrophages to low-output nitric oxide (NO), TNF-α and interleukin (IL)-1ß to kill and clean bacteria. Importantly, these polymers can efficiently inhibit aminoglycoside-resistant P. aeruginosa even at a low dose of 500 nmol L-1. Furthermore, these polymers can treat subcutaneous bacterial infections in vivo. In this study, we first report a water-soluble branched polymer to combat bacteria through the combination of chemotherapy and immunotherapy, which will open a new path to design promising potential therapeutic alternatives for bacterial infection.

18.
Ann Transl Med ; 9(20): 1585, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34790791

RESUMO

Background: Long-term exposure to a high-altitude environment with low pressure and low oxygen can cause abnormalities in the structure and function of the heart, in particular the right ventricle. Monitoring the structure and function of the right ventricle is therefore essential for early diagnosis and prognosis of high-altitude heart-related diseases. In this study, 7.0 T MRI is used to detect cardiac structure and function indicators of rats in natural plateau and plain environments. Methods: Rats in two groups were raised in different environments from 6 weeks of age for a period of 12 weeks. At 18 weeks of age both groups underwent 7.0 T cardiac magnetic resonance (CMR) scanning. Professional cardiac post-processing software was used to analyze right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV), right ventricular stroke volume (RVSV), right ventricular ejection fraction (RVEF), Right ventricular end-diastolic myocardial mass (RV Myo mass, diast), Right ventricular end-systolic myocardial mass (RV Myo mass, syst), tricuspid valve end-diastolic caliber (TVD), tricuspid valve end-systolic caliber (TVS), right ventricular end-systolic long-axis (RVESL) and right ventricular end-diastolic long-axis (RVEDL). Prior to the CMR scan, blood was collected from the two groups of rats for evaluation of blood indicators. After the scan, the rats were sacrificed and the myocardial tissue morphology observed under a light microscope. Results: In the group of rats subject to chronic hypoxia at high altitude for 12 weeks (the plateau group), red blood cell (RBC) count, hemoglobin (HGB) and hematocrit (HCT) increased (P<0.05); RVEDV, RVESV, RVSV, RV Myo mass (diast), RV Myo mass (syst), TVS, RVESL, and RVEDL also increased (P<0.05). Observation of the right ventricle of rats in the plateau group using a light microscope mainly showed a slightly widened myocardial space, myocardial cell turbidity, vacuolar degeneration, myocardial interstitial edema, vascular congestion and a small amount of inflammatory cell infiltration. Conclusions: The importance of ultra-high-field MRI for monitoring the early stages of rat heart injury has been demonstrated by studying the changes in the structure and function of the right ventricle of rats subject to chronic hypoxia at high altitude over a period of 12 weeks.

19.
Artigo em Inglês | MEDLINE | ID: mdl-34817164

RESUMO

Zone-melted Bi2Te3-based alloys are the only commercially available thermoelectric (TE) materials, but they suffer from mediocre figure of merit (ZT) values and brittleness. In this work, we prepared Bi0.48Sb1.52Te3 sintered samples using a hot-pressing method and added tiny AgCuTe to improve the comprehensive properties. Because the carrier concentration is boosted by the AgCuTe addition, the bipolar effect at higher temperature is explicitly suppressed and the power factor is also improved in a broad temperature scope. Simultaneously, κlat is mostly diminished by the introduced phonon scattering centers comprising point defects, dislocations, and grain boundaries. Consequently, we achieved a ZTmax of 1.25 at 350 K and its average ZTave of 1.1 from 300 to 500 K in the (Bi0.48Sb1.52Te3 + 3 wt % Te) + 0.12 wt % AgCuTe sample. Composed of this sample and commercial Bi2Te2.5Se0.5, the fabricated TE module manifests a maximum power output density of 0.31 W cm-2 (Tcold = 300 K and Thot = 500 K). This work suggests that AgCuTe-doped Bi0.48Sb1.52Te3 is promising for recovering low-grade thermal energy near room temperature.

20.
Nano Lett ; 21(22): 9476-9484, 2021 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-34730354

RESUMO

The small molecular inhibitor-associated downregulation of autophagy can remarkably enhance the efficiency of photothermal cancer therapy. To identify a more effective autophagy inhibitor, we screened a library of 20 compounds and found chloroquine, hydroxychloroquine, dauricine, and daurisoline were more efficient than the others to improve the photothermal killing of cancer cells. Interestingly, the four agents all disturb the autophagosome formation and fusion process, indicating it is a promising target to enhance cancer therapeutic efficiency. Among the four agents, daurisoline was identified to be the most efficient one. It reduced the viability of cancer cells treated by low-energy photothermal therapy from 86.27% to 32.92%. Finally, the combination treatment mediated by nanodrugs loaded with daurisoline and indocyanine green was more efficient than the individual modalities, resulting in complete inhibition of tumor growth. The study gives new inspiration to autophagy modulation-associated photothermal therapy and other therapeutic modalities for cancer treatment.

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