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1.
Photodiagnosis Photodyn Ther ; : 102048, 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33017657

RESUMO

The research is to propose a new classification framework, called diverse spectral band-based deep residual network (DSB-ResNet), which can distinguish tongue squamous cell carcinoma (TSCC) from non-cancerous tissue. A fiber optic Raman spectroscopy system is used to collect Raman spectral data of TSCC and normal tissues. DSB-ResNet takes advantage of diverse spectral band-based spectra without processing to derive spectral representations from different spectral bands of Raman spectra, which improves the ability to identify TSCC. To show the superiority of the proposed method, the existing methods are used as the competitive methods to compare with the DSB-RestNet, the results demonstrate our method has the highest performance with 97.38%, 98.75%, and 98.25% for sensitivity, specificity, and accuracy, respectively. The experimental results show that the DSB-ResNet is able to distinguish TSCC from non-cancerous tissue successfully. The proposed method is expected to provide a theoretical and methodological base for accurate detection of TSCC.

2.
J Sports Sci ; : 1-9, 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33019892

RESUMO

This study aimed to examine whether changes in physical activity (PA) after an 8-week pedometer-based intervention would result in changes on motor competence through competence beliefs towards physical education (PE). The study also evaluated whether the hypothesized causal pathway differed by gender. Participants were 259 children (Mean age  = 10.88, SD =.78), randomly allocated to three intervention groups. Children's PA, competence beliefs towards PE, and motor competence were measured at pre- and post-tests. Significant relationships between PA and competence beliefs towards PE were found at pre- and post-tests. The magnitude of the relationship between competence beliefs towards PE and motor competence was larger at post-test than at pre-test (.33 vs.20). The structural invariance test suggested that the differences between boys and girls for the hypothesized models were insignificant (CMIN = 15.97, df = 12; p =.193). In general, the results suggest that changes on PA may cause changes in competence beliefs towards PE, which could result in changes on motor competence in middle to later childhood, regardless of gender. These data offer the possibility of using competence beliefs towards PE as a mediator in PA interventions designed to increase motor competence in childhood.

3.
Artigo em Inglês | MEDLINE | ID: mdl-33029955

RESUMO

BACKGROUND: Endoscopic sinus surgery (ESS) is used to treat chronic rhinosinusitis. However, nasal adhesions often develop postoperatively, triggered by chronic inflammation and local fibrosis. A poly L-lactide (PLLA) electrospun microfibrous membrane is a functional biodegradable material that can be placed on the wound surface to protect the wound and prevent adhesions. METHODS: We divided 24 rabbits randomly into 2 groups, a control operation group (group A) and an operation+PLLA placement group (group B). We investigated the anti-fibrotic effects of the topical biomaterial after sinus surgery. We placed PLLA fibrous membranes in the sinus cavity of group B rabbits after sinus surgery, and then evaluated changes in the mucosa and in the levels of collagen fibers, interleukin 4 (IL-4), IL-8, tumor necrosis factor α (TNF-α), transforming growth factor ß1 (TGF-ß1), α-smooth muscle actin (α-SMA), and collagen I (Col I), using morphological and molecular biological methods. RESULTS: PLLA fibrous membranes did not inhibit the synthesis of messenger RNAs (mRNAs) encoding IL-4, IL-8, or TNF-α, or the protein levels, indicating that the membrane did not have an anti-inflammatory effect. However, the membrane inhibited the synthesis of mRNAs encoding TGF-ß1, α-SMA, and Col I, and reduced collagen production. Thus, the nanostructured membrane inhibited fibroblast proliferation. CONCLUSION: The PLLA membrane had anti-fibrotic effects, and may be used to prevent fibrosis and adhesions after ESS in human patients.

4.
Ann Palliat Med ; 9(5): 3162-3169, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33065782

RESUMO

BACKGROUND: Evaluate the accuracy of IWI predicting weaning in patients with mechanical ventilation greater than 72 hours. METHODS: All patients were divided into two groups, according to FiO2 in the intensive care unit (ICU) with mechanically ventilated for more than 72 hours. Recorded Integrative weaning index (IWI) related indicators in all patients. Evaluate the accuracy of IWI predicting weaning success. RESULTS: Within these 50 patients, 32 of them were weaning successfully, and 18 of the patients failed. Using IWI >45.70 mL/cmH2O breaths/minute/liter as a threshold of predicting successful weaning, the sensitivity is 0.91, and the specificity is 0.83. The AUC of IWI was 0.91. In the group with FiO2 =0.40, 17 patients were successfully liberated from MV, while 8 patients failed. The sensitivity is 0.8235, and specificity is 0.88 using IWI >50.40 mL/cmH2O breath/minute/liter as a threshold for predicting the outcome of weaning. The AUC of IWI was 0.846±0.117. In the FiO2 =0.35 group, 15 patients were successfully liberated from MV, while 10 patients failed. Using IWI >39.33 mL/cmH2O breaths/minute/liter, as a threshold to predict successful weaning, results in a sensitivity of 0.93 and a specificity of 0.90. The AUC of IWI was 0.953±0.395. CONCLUSIONS: Results showed IWI has a significantly higher AUC value compared with other traditional weaning indexes. Hence, it can be a significant predictor for weaning outcomes.

5.
Nanotechnology ; 31(50): 50LT01, 2020 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-33034304

RESUMO

A microtubule hollow structure is one type of cytoskeletons which directs a number of important cellular functions. When recapitulating biological events in a cell-free system, artificial frames are often required to execute similar cytoskeletal functions in synthetic systems. Here, I report a prototypical microtubular assembly using a DNA origami nanostructuring method. Through structural design at the molecular level, 32HB (helices bundle)-based DNA origami objects can form micrometers long tubular structures via shape-complementary side patterns engagement and head-to-tail blunt-end stacking. Multiple parameters have been investigated to gain optimized polymerization conditions. Conformational change with an open vs closed hinge is also included, rendering conformational changes for a dynamic assembly. When implementing further improved external regulation with DNA dynamics (DNA strand displacement reactions or using other switchable non-canonical DNA secondary structures) or chemical stimuli, the DNA origami-based microtubule analogue will have great potential to assemble and disassemble on purpose and conduct significantly complicated cytoskeletal tasks in vitro.

6.
Theranostics ; 10(24): 11144-11158, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33042275

RESUMO

Rationale: Radioresistance remains the major cause of local relapse and distant metastasis in lung cancer. However, the underlying molecular mechanisms remain poorly defined. This study aimed to investigate the role and regulatory mechanism of Cyclin K in lung cancer radioresistance. Methods: Expression levels of Cyclin K were measured by immunohistochemistry in human lung cancer tissues and adjacent normal lung tissues. Cell growth and proliferation, neutral comet and foci formation assays, G2/M checkpoint and a xenograft mouse model were used for functional analyses. Gene expression was examined by RNA sequencing and quantitative real-time PCR. Protein-protein interaction was assessed by immunoprecipitation and GST pull-down assays. Results: We report that Cyclin K is frequently overexpressed and correlates with poor prognosis in lung cancer patients. Functionally, we demonstrate that Cyclin K depletion results in reduced proliferation, defective G2/M checkpoint and enhanced radiosensitivity in lung cancer. Mechanistically, we reveal that Cyclin K interacts with and promotes the stabilization of ß-catenin protein, thereby upregulating the expression of Cyclin D1. More importantly, we show that Cyclin D1 is the major effector that mediates the biological functions of Cyclin K in lung cancer. Conclusions: These findings suggest that Cyclin K positively modulates the ß-catenin/Cyclin D1 axis to promote tumorigenesis and radioresistance in lung cancer, indicating that Cyclin K may represent a novel attractive biomarker for lung cancer radiotherapy.

7.
ChemSusChem ; 2020 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-33047881

RESUMO

Polyvinyl chloride (PVC) is the world's third-most widely produced plastic polymer. Directly transforming PVC to carbonaceous materials for CO 2 capture provides an environmentally-friendly attractive strategy to recycle plastics. In this work, we developed a simple and effective method to prepare PVC-derived carbon spheres. In this method, the classical "spheroidization" process shaped the original PVC powders into millimeter spheres, and special dehalogenation and cross-linking process in the presence of a phase transfer catalyst transferred thermoplasticity of the PVC-spheres into thermosetting, which stabilized the shape. Furthermore, by rationally adjusting the activation conditions, the porous structure of the carbon spheres was well optimized. With the specific surface area up to 1738 m 2 /g and the developed microporous structure, the as-prepared carbon spheres possess not only excellent performance in pure CO 2 adsorption (8.93 mmol g-1, 39.3 wt.% at 0 °C and 5.47 mmol g-1, 24.1 wt.% at 25 °C), but also outstanding adsorption capacity and recyclability in low concentration CO 2 capture, even superior to conventional molecular sieves.

8.
J Epidemiol ; 2020 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-33012776

RESUMO

BackgroundTo investigate the causal link between early-life exposures and long-term health consequences, we established the Tianjin Birth Cohort (TJBC), a large-scale prospective cohort in northern China.MethodsTJBC aims to enroll 10,000 families with follow-ups from pregnancy until children's six year-old. Pregnant women and their spouses were recruited through a three-tier antenatal healthcare system at early pregnancy, with follow-ups at mid-pregnancy, late pregnancy, delivery, 42 days after delivery, 6 months after delivery and each year until 6 year-old. Antenatal/neonatal examination, biological samples and questionnaires were collected.ResultsFrom August 2017 to January 2019, a total of 3,924 pregnant women has already been enrolled, and 1697 women have given birth. We observed the prevalence of gestational diabetes mellitus as 18.1%, anemia as 20.4%, and thyroid hypofunction as 2.0%. In singleton live births, 5.6% were preterm birth (PTB), 3.7% were low birth weight and 7.3% were macrosomia. Based on current data, we also identified maternal/paternal factors which increased the risk of PTB, including paternal age (OR, 1.07; 95% CI, 1.01-1.14 for each year increase), vaginal bleeding during pregnancy (OR, 2.82; 95% CI, 1.54-5.17) and maternal early-pregnancy BMI (OR, 1.08; 95% CI, 1.01-1.15 for each kg/m2 increase).ConclusionTJBC has the strength of collecting comprehensive maternal, paternal and childhood information. With a diverse range of biological samples, we are also engaging with emerging new technologies for multi-omics researches. The study would provide new insight into the causal link between macro/micro-environmental exposures of early life and short/long-term health consequences.

9.
Sensors (Basel) ; 20(19)2020 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-32998435

RESUMO

With the improvement of semiconductor technology, the performance of CMOS Image Sensor has been greatly improved, reaching the same level as that of CCD in dark current, linearity and readout noise. However, due to the production process, CMOS has higher fix pattern noise than CCD at present. Therefore, the removal of CMOS fixed pattern noise has become the research content of many scholars. For current fixed pattern noise (FPN) removal methods, the most effective one is based on optimization. Therefore, the optimization method has become the focus of many scholars. However, most optimization models only consider the image itself, and rarely consider the structural characteristics of FPN. The proposed sparse unidirectional hybrid total variation (SUTV) algorithm takes into account both the sparse structure of column fix pattern noise (CFPN) and the random properties of pixel fix pattern noise (PFPN), and uses adaptive adjustment strategies for some parameters. From the experimental values of PSNR and SSM as well as the rate of change, the SUTV model meets the design expectations with effective noise reduction and robustness.

10.
Phytomedicine ; 79: 153346, 2020 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-33002828

RESUMO

BACKGROUND: Immunoglobulin E (IgE)-mediated mast cell (MC) activation is crucial in multiple allergic diseases. Parkinson disease protein 7 (DJ-1) and Lyn kinase were reported as the receptor-proximal events in IgE receptor (FcεRI) signals in human MC. Kaempferol, a natural flavonol mainly derived from the rhizome of traditional Chinese herb Kaempferia galanga L. (Zingiberaceae), has been known to inhibit allergic reactions, but it was limited to the receptor-distal signals on rat basophilic leukemia cells. A thorough investigation of the inhibitory effects of kaempferol on human MC has not been done. PURPOSE: To investigate the inhibitory effects of kaempferol on IgE-mediated anaphylaxis in vivo and in human MCs, as well as the mechanism underlying its effects, especially the receptor-proximal signals. METHODS: IgE-mediated passive cutaneous anaphylaxis and systemic anaphylaxis model were applied to elucidate the antiallergic activity of kaempferol in vivo. The degranulation assay, calcium imaging, the release of cytokines and chemokines on the laboratory of allergic disease 2 (LAD2) cells were used to evaluate the antiallergic effect of kaempferol in vitro. Western blot analysis was performed to investigate the DJ-1/Lyn signaling pathway and downstream molecules. Kinase activity assay, immunofluorescence, and molecular docking were conducted to confirm the influence of kaempferol on DJ-1/Lyn molecules. RESULTS: Kaempferol dose-dependently attenuated ovalbumin/IgE-induced mice paw swelling, primary MC activation from paw skin, as well as rehabilitated the hypothermia, and reduced the serum concentrations of histamine, tumor necrosis factor-alpha, interleukin-8, and monocyte chemo-attractant protein-1. Additionally, kaempferol suppressed IgE-mediated LAD2 cell degranulation and calcium fluctuation. Remarkably, kaempferol was found to bind with DJ-1 protein, and initially prevented DJ-1 from translocating to the plasma membrane, thereby inhibited full activation of Lyn, and eventually restrained those receptor-distal signaling molecules, involved Syk, Btk, PLCγ, IP3R, PKC, MAPKs, Akt and NF-κB. CONCLUSION: Kaempferol could be used as a DJ-1 modulator for preventing MC-mediated allergic disorders through attenuating Lyn activation.

11.
Cancer Lett ; 496: 57-71, 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33038488

RESUMO

Despite the growing recognition of metabolic reprogramming as an important hallmark of cancer in the past few years, the molecular mechanisms underlying metabolic alterations during tumorigenesis remain unclear. In this study, we identified a critical role of Her4 in rewiring cancer metabolism toward tumor-promoting metabolic processes, including increased glycolysis, glutaminolysis, mitochondrial biogenesis, and oxidative phosphorylation, which may in part cooperate to promote tumorigenesis. We found that overexpression of Her4 promoted the stabilization of c-Myc through a CIP2A-mediated increase in c-MycS62 phosphorylation and GSK3ß-mediated decrease in c-MycT58 phosphorylation, both of which decreased c-Myc degradation. Furthermore, Her4 was found to increase glucose uptake and tumor growth in an osteosarcoma xenograft model. Overall, these findings provide a better understanding of the involvement of Her4 in tumorigenesis and document its potential role in metabolic reprogramming for the first time. We believe that our study might lead to promising opportunities for targeted metabolic therapy for cancer.

12.
Biomark Med ; 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33064019

RESUMO

Aim: This study examined the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severity of calcific aortic valve stenosis (CAVS) in a Chinese case-control study. Results: The LMR significantly decreased in the patients with CAVS compared with healthy controls. An inverse correlation was observed between the severity of stenosis and LMR in the patients. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe CAVS. Conclusion: This study provides evidence of an inverse correlation between the severity of CAVS and LMR. LMR could potentially be applied as an independent predictor of severe CAVS and could be incorporated into a novel predictive model.

13.
Cancer Biol Ther ; : 1-11, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33064958

RESUMO

FGF13, a member of the FGF subfamily, has been found to be highly expressed in cancer cells such as prostate cancer, melanoma, glioma and multiple myeloma. However, the mechanism of FGF13 function during cancer cell proliferation remains to be unexplored, especially Non-small cell lung cancer (NSCLC). In this study, the cell proliferation effect of FGF13 on A549 cells was checked by CCK-8, clone formation, Ki67 immunofluorescence staining and Flow Cytometry assay. Localization of FGF13 within A549 cells was performed with confocal laser scanning microscope. The protein variations and interaction were measured by western blotting and co-immunoprecipitation analysis. It showed that FGF13 was mainly distributed in the cytoplasm and exhibited a high expression level in A549 cells. High expression of FGF13 activated AKT-GSK3 signaling pathway, and inhibited the activity of p21 and p27. Thus, FGF13 enhanced the process of transition from G1 to S phase and promoted A549 cells proliferation. Furthermore, the interaction between FGF13 and SHCBP1 was confirmed. Meanwhile, FGF13 and SHCBP1 had a cooperative effect to accelerate the cell cycle progression, especially the ability to promote cell proliferation is significantly enhanced via protein interaction. Hence, we conclude that FGF13 played a positive regulation role during A549 cells proliferation. FGF13 interacted with SHCBP1 to facilitate cell cycle progression, providing new insights into deep understanding of non-small cell lung cancer mechanisms of proliferation and regulation function of FGF13.

14.
Int J Biol Macromol ; 2020 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-32891644

RESUMO

As one type of the solid wastes, the increasing contamination of waste cellulose diacetate (CDA) from discarded cigarette filters is a growing problem worldwide. Finding a facile and suitable approach to convert the CDA into value-added materials is of significance. Herein, we reported a green, simple and effective method to reuse CDA as precursor for preparing fluorescence N-doped carbon dots (N-CDs) via one-pot hydrothermal carbonization in aqueous solution with low-cost ammonium hydroxide as the passivation agent. The N-CDs showed a quantum yield up to 22.4% with a maximum emission at 415 nm and excitation at 320 nm. Interestingly, the N-CDs exhibited high selectivity toward tetracycline (TC) as their fluorescence was obviously quenched by TC as a result of inner-filter effect. A linear relationship was fabricated over concentration range of 0-80 µM with a detection limit of 0.06 µM. Moreover, the N-CDs could also be applied as fluorescent ink for anti-forgery.

15.
J Clin Pharm Ther ; 2020 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-32893899

RESUMO

WHAT IS KNOWN AND OBJECTIVE: Several immune checkpoint inhibitors (ICIs) are now available for treatment of non-small cell lung cancer (NSCLC). However, not all patients benefit from ICI therapy, and the choice of ICIs is limited. CASE SUMMARY: A 54-year-old man with locally advanced NSCLC achieved partial response after definitive chemoradiotherapy. When he opted for consolidation therapy, metastatic lesions were found. Surprisingly, after immunotherapy with toripalimab, he quickly achieved complete response. WHAT IS NEW AND CONCLUSION: As a PD-1 inhibitor, toripalimab may be an effective option for subsequent therapy of patients with locally advanced NSCLC after concurrent chemoradiotherapy.

16.
J Am Coll Health ; : 1-8, 2020 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-32877625

RESUMO

OBJECTIVE: This study aimed to investigate interactions among physical fitness, sleep quality, sedentary behavior, and depression among female college freshmen. Participants: A cohort of 1,514 Chinese female college freshmen (Mage = 18.8 ± .63) were recruited from four universities. Methods: Participants completed a survey assessing depression, sleep quality (sleep duration and sleep onset latency), and sedentary behavior, and performed physical fitness measurements. Results: Physical fitness indexes were associated with sleep quality and sedentary behavior (ps < .05) but not with depression. Depression was positively associated with sedentary behavior and sleep onset latency, but negatively associated with sleep duration (ps < .01). The model tests revealed that sleep quality (ß = -.57, p < .01) and sedentary behavior (ß = .14, p < .01) served as mediators between physical fitness and depression, respectively. Conclusions: Increasing sleep quality and minimizing sedentary behavior may build resilience to depression among Chinese female college freshmen.

17.
IEEE Trans Med Imaging ; PP2020 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-32866095

RESUMO

In this work, we investigate the Fourier properties of a symmetric-geometry computed tomography (SGCT) with linearly distributed source and detector in a stationary configuration. A linkage between the 1D Fourier Transform of a weighted projection from SGCT and the 2D Fourier Transform of a deformed object is established in a simple mathematical form (i.e., the Fourier slice theorem for SGCT). Based on its Fourier slice theorem and its unique data sampling in the Fourier space, a Linogram-based Fourier reconstruction method is derived for SGCT. We demonstrate that the entire Linogram reconstruction process can be embedded as known operators into an end-to-end neural network. As a learning-based approach, the proposed Linogram-Net has capability of improving CT image quality for non-ideal imaging scenarios, a limited-angle SGCT for instance, through combining weights learning in the projection domain and loss minimization in the image domain. Numerical simulations and physical experiments on an SGCT prototype platform showed that our proposed Linogram-based method can achieve accurate reconstruction from a dual-SGCT scan and can greatly reduce computational complexity when compared with the filtered backprojection type reconstruction. The Linogram-Net achieved accurate reconstruction when projection data are complete and significantly suppressed image artifacts from a limited-angle SGCT scan mimicked by using a clinical CT dataset, with the average CT number error in the selected regions of interest reduced from 67.7 Hounsfield Units (HU) to 28.7 HU, and the average normalized mean square error of overall images reduced from 4.21e-3 to 2.65e-3.

18.
Inorg Chem ; 2020 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-32865397

RESUMO

The pore-size effect on ethane adsorption and ethane/ethylene separation in three isostructural metal azolate frameworks (MAF-123-Mn/Zn/Cu) were thoroughly investigated. MAF-123-Mn/Zn/Cu were synthesized by the solvothermal method on a gram scale. Decreasing the pore size from 6.1 to 4.9 Å leads to an increase in the ethane adsorption energy from 23 to 27.5 kJ mol-1 and further ethane/ethylene separation efficiency. Molecule simulations revealed that a shorter ethane-framework interaction distance in MAF-123-Zn than that in MAF-123-Mn is responsible for the increased adsorption energy. Dynamic breakthrough experiments manifest that these metal azolate frameworks can effectively produce high-purity ethylene from ethane in one adsorption step.

19.
BMC Infect Dis ; 20(1): 651, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32887563

RESUMO

BACKGROUND: Risk factors related to mortality due to invasive pneumococcal disease (IPD) have been unveiled previously, but early clinical manifestations of IPD based on prognosis remain uncovered. METHODS: The demographic characteristics, clinical features, serotype, antibiotic susceptibility, and outcomes of 97 hospitalized children with laboratory-confirmed IPD from Suzhou, China, were collected and analyzed retrospectively. RESULTS: The median age was 0.69 (0.49-1.55) years in the non-survivor group compared with 2.39 (0.90-3.81) years in the survivor group. The mortality of 97 children with laboratory-confirmed IPD was 17.5% (17/97), and 53.6% of them were aged less than 2 years. Pathogens were mainly from the blood and cerebrospinal fluid, and sepsis was the most frequent type. Statistically significant differences were found in hyperpyrexia, vomiting, anorexia, lethargy, poor perfusion of extremities, Hb level, and Plt count between the nonsurvival and survival groups. Further, the multivariate regression analysis showed that early signs, including hyperpyrexia, vomiting, anorexia, lethargy, and poor perfusion of extremities, were independent risk factors for the in-hospital mortality of children with laboratory-confirmed IPD. The mortality was also associated with antimicrobial sensitivity in pneumococcal isolates. The microbes in 1/17 (5.9%) children who were prescribed an antibiotic showed antimicrobial sensitivity in the nonsurvival group, compared with 21/80 (26.3%) children who survived. The most common serotypes identified were 6B (35.3%, 6/17), 14 (23.5%, 4/17), 19F (23.5%, 4/17), 19A (5.9%, 1/17), 23F (5.9%, 1/17), and 20 (5.9%, 1/17) in the nonsurvival group. The coverage of IPD serotypes of the 7-valent pneumococcal conjugate vaccine (PCV7) was 88.2% (15/17), while that of the 13-valent S. pneumoniae vaccine (PCV13) was 94.1% (16/17) of the coverage in the nonsurvival group. CONCLUSIONS: Recurrent hyperpyrexia, vomiting, anorexia, lethargy, and poor perfusion of extremities in the early stage were independent predictors for the in-hospital mortality of children with laboratory-confirmed IPD. Appropriate use of antibiotics and PCV immunization were the keys to improve the outcome of IPD.


Assuntos
Infecções Pneumocócicas/microbiologia , Infecções Pneumocócicas/mortalidade , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Pré-Escolar , Feminino , Vacina Pneumocócica Conjugada Heptavalente/uso terapêutico , Mortalidade Hospitalar , Humanos , Lactente , Masculino , Testes de Sensibilidade Microbiana , Infecções Pneumocócicas/tratamento farmacológico , Infecções Pneumocócicas/prevenção & controle , Vacinas Pneumocócicas/uso terapêutico , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Sepse/microbiologia , Streptococcus pneumoniae/isolamento & purificação , Cobertura Vacinal
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