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1.
Nurse Educ Pract ; 52: 103040, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33813343

RESUMO

Practicing in unprecedented working environment and fighting against the COVID-19 crisis influenced the image of nursing in the general population, as well as among nurses themselves. This study aimed to describe the sense of professional identity among Chinese nursing students during the COVID-19 outbreak and to explore the relationship between psychological resilience and the sense of professional identity in this cohort. A nationwide online cross-sectional survey was conducted. Nursing students were recruited from 18 Chinese universities. The 10-item Connor-Davidson resilience scale (CD-RISC-10) evaluated psychological resilience and professional identity was assessed by the Professional Identity Questionnaire for Nursing Students (PIQNS). A total of 6348 respondents had a moderate level of professional identity to nursing (average PIQNS score at 62.02 ± 12.02). About 86% of respondents attributed the response to the COVID-19 pandemic in elevating the nursing image. Psychological resilience was the strongest contributor to professional identity (ß = 0.371, P < 0.001). There was a high level of professional identity among Chinese nursing students during the COVID-19 crisis. Policy support and courses to enhance psychological resilience are critical to sustain professional identity among nursing students.

2.
ACS Nano ; 2021 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-33821615

RESUMO

When approaching the subwavelength or deep subwavelength scale, there is a fundamental trade-off between the ultimate shrinking size and the performance for miniaturized lasers. Herein, to overcome this trade-off, we investigated the excitonic gain nature of quasi-two-dimensional (quasi-2D) perovskites and revealed that both singlet excitons and polarons would make nearly the entire contribution within ∼50 ps to a high net gain of 558 cm-1. Inspired by the gain characteristic, we successfully shrank the quasi-2D perovskites laser to the subwavelength scale using only a layer of ultraviolet glue and a glass substrate in the vertical dimension. In spite of the compact and simple cavity structure, single-mode lasing with a highly linear polarization degree of 81% and a quality factor of 1635 was achieved. The extremely short cavity, excellent lasing performance, and simple structure of the quasi-2D perovskite laser are expected to provide insights into next-generation integrated laser sources.

3.
Oncol Rep ; 45(6)2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33846801

RESUMO

Cholangiocarcinoma (CCA) is the second most common type of hepatocellular carcinoma characterized by high aggressiveness and extremely poor patient prognosis. The germ cell­specific gene 2 protein (GSG2) is a histone H3 threonine­3 kinase required for normal mitosis. Nevertheless, the role and mechanism of GSG2 in the progression and development of CCA remain elusive. In the present study, the association between GSG2 and CCA was elucidated. Firstly, we demonstrated that GSG2 was overexpressed in CCA specimens and HCCC­9810 and QBC939 cells by immunohistochemical (IHC) staining. It was further revealed that high expression of GSG2 in CCA had significant clinical significance in predicting disease deterioration. Subsequently, cell proliferation, apoptosis, cell cycle distribution and migration were measured by MTT, flow cytometry, and wound healing assays, respectively in vitro. The results demonstrated that downregulation of GSG2 decreased proliferation, promoted apoptosis, arrested the cell cycle and weakened migration in the G2 phase of CCA cells. Additionally, GSG2 knockdown inhibited CCA cell migration by suppressing epithelial­mesenchymal transition (EMT)­related proteins, such as N­cadherin and vimentin. Mechanistically, GSG2 exerted effects on CCA cells by modulating the PI3K/Akt, CCND1/CDK6 and MAPK9 signaling pathways. In vivo experiments further demonstrated that GSG2 knockdown suppressed tumor growth. In summary, GSG2 was involved in the progression of CCA, suggesting that GSG2 may be a potential therapeutic target for CCA patients.

4.
Polymers (Basel) ; 13(7)2021 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-33805562

RESUMO

Lignin accounts for approximately 30% of the weight of herbaceous biomass. Utilizing lignin in asphalt pavement industry could enhance the performance of pavement while balancing the construction cost. This study aims to evaluate the feasibility of utilizing lignin as a bitumen performance improver. For this purpose, lignin derived from aspen wood chips (labeled as KL) and corn stalk residues (labeled as CL) were selected to prepare the lignin modified bituminous binder. The properties of the lignin modified binder were investigated through rheological, mechanical and chemical tests. The multiple stress creep recovery (MSCR) test results indicated that adding lignin decreased the Jnr of based binder by a range of 8% to 23% depending on the stress and lignin type. Lignin showed a positive effect on the low temperature performance of asphalt binder, because at -18 °C, KL and CL were able to reduce the stiffness of base binder from 441 MPa to 369 MPa and 378 MPa, respectively. However, lignin was found to deteriorate the fatigue life and workability of base binder up to 30% and 126%. With bituminous mixture, application of lignin modifiers improved the Marshall Stability and moisture resistance of base mixture up to 21% and 13%, respectively. Although, adding lignin modifiers decreased the molecular weight of asphalt binder according to the gel permeation chromatography (GPC) test results. The Fourier-transform infrared spectroscopy (FTIR) test results did not report detectable changes in functional group of based binder.

5.
BMC Med Inform Decis Mak ; 21(1): 128, 2021 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-33858409

RESUMO

BACKGROUND: Semantic categorization analysis of clinical trials eligibility criteria based on natural language processing technology is crucial for the task of optimizing clinical trials design and building automated patient recruitment system. However, most of related researches focused on English eligibility criteria, and to the best of our knowledge, there are no researches studied the Chinese eligibility criteria. Thus in this study, we aimed to explore the semantic categories of Chinese eligibility criteria. METHODS: We downloaded the clinical trials registration files from the website of Chinese Clinical Trial Registry (ChiCTR) and extracted both the Chinese eligibility criteria and corresponding English eligibility criteria. We represented the criteria sentences based on the Unified Medical Language System semantic types and conducted the hierarchical clustering algorithm for the induction of semantic categories. Furthermore, in order to explore the classification performance of Chinese eligibility criteria with our developed semantic categories, we implemented multiple classification algorithms, include four baseline machine learning algorithms (LR, NB, kNN, SVM), three deep learning algorithms (CNN, RNN, FastText) and two pre-trained language models (BERT, ERNIE). RESULTS: We totally developed 44 types of semantic categories, summarized 8 topic groups, and investigated the average incidence and prevalence in 272 hepatocellular carcinoma related Chinese clinical trials. Compared with the previous proposed categories in English eligibility criteria, 13 novel categories are identified in Chinese eligibility criteria. The classification result shows that most of semantic categories performed quite well, the pre-trained language model ERNIE achieved best performance with macro-average F1 score of 0.7980 and micro-average F1 score of 0.8484. CONCLUSION: As a pilot study of Chinese eligibility criteria analysis, we developed the 44 semantic categories by hierarchical clustering algorithms for the first times, and validated the classification capacity with multiple classification algorithms.

6.
J Neurochem ; 2021 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-33733478

RESUMO

Stroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological process is extremely complicated and unclear. Although many basic studies have confirmed molecular mechanism of brain injury after stroke, these studies have not yet translated into treatment and clinical application. Ferroptosis is a form of cell death that is distinct from necrosis, apoptosis, and autophagy morphologically and biochemically and is characterized by iron-dependent accumulation of lipid peroxides. Despite ferroptosis being first identified in cancer cells, it was recently revealed to also be a significant factor in the pathological process of stroke. A better understanding of ferroptosis in stroke may provide us with better therapeutic targets to treat this devastating disease. Here, we systematically summarized the current mechanism of ferroptosis and reviewed the current studies regarding the relationship between ferroptosis and stroke.

7.
Biostatistics ; 2021 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-33634822

RESUMO

The main challenge in cancer genomics is to distinguish the driver genes from passenger or neutral genes. Cancer genomes exhibit extensive mutational heterogeneity that no two genomes contain exactly the same somatic mutations. Such mutual exclusivity (ME) of mutations has been observed in cancer data and is associated with functional pathways. Analysis of ME patterns may provide useful clues to driver genes or pathways and may suggest novel understandings of cancer progression. In this article, we consider a probabilistic, generative model of ME, and propose a powerful and greedy algorithm to select the mutual exclusivity gene sets. The greedy method includes a pre-selection procedure and a stepwise forward algorithm which can significantly reduce computation time. Power calculations suggest that the new method is efficient and powerful for one ME set or multiple ME sets with overlapping genes. We illustrate this approach by analysis of the whole-exome sequencing data of cancer types from TCGA.

8.
Dis Markers ; 2021: 8860728, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33574966

RESUMO

DNA double-strand break (DSB) repaired by homologous recombination (HR) is an essential process for breast cancer cells to survive. DNA2 nuclease acts parallel to homologous recombination (HR). Here, we investigated the detailed clinical attribute of DNA2 in breast cancer and the role of DNA2 in breast cancer cells' growth. We found that elevated expression of DNA2 was obviously linked to poor prognosis in breast cancer. Further, DNA2 expression was increased in the ER-negative group, PR-negative group, HER2-positive group, and high-grade group via analyzing 2,509 breast cancers in "cBioportal" and 3,063 breast cancer data in "bc-GenExMiner." Besides, the immunohistochemical staining in 26 breast cancer tissues also showed that elevated expression of DNA2 was correlated with ER-/PR-/HER+. To further detect the role of DNA2 in breast cancer cells, we took GESA, GO, and KEGG analyses and found that DNA2 was enriched in cell cycle and DNA replication pathways. Furthermore, silencing of DNA2 inhibited cell growth in T47D and MD-MB-231 breast cancer cells and suppressed tumor growth in vivo, indicating DNA2 functioned importantly in breast cancer progression and maybe a potential prognostic marker in breast cancer. Our research reveals that DNA2 is a biomarker for diagnosis and prognosis in breast cancer from multiple perspectives and gives a new clue for further preclinical and clinical investigation.

9.
Plant J ; 2021 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-33506534

RESUMO

In mammals, DNA methylation is associated with aging. However, age-related DNA methylation changes during phase transitions largely remain unstudied in plants. Moso bamboo (Phyllostachys edulis) requires a very long time to transition from the vegetative to the floral phase. To comprehensively investigate the association of DNA methylation with aging, we present here single-base-resolution DNA methylation profiles using both high-throughput bisulfite sequencing and single-molecule nanopore-based DNA sequencing, covering the long period of vegetative growth and transition to flowering in moso bamboo. We discovered that CHH methylation gradually accumulates from vegetative to reproductive growth in a time-dependent fashion. Differentially methylated regions, correlating with chronological aging, occurred preferentially at both transcription start sites and transcription termination sites. Genes with CG methylation changes showed an enrichment of Gene Ontology (GO) categories in 'vegetative to reproductive phase transition of meristem'. Combining methylation data with mRNA sequencing revealed that DNA methylation in promoters, introns and exons may have different roles in regulating gene expression. Finally, circular RNA (circRNA) sequencing revealed that the flanking introns of circRNAs are hypermethylated and enriched in long terminal repeat (LTR) retrotransposons. Together, the observations in this study provide insights into the dynamic DNA methylation and circRNA landscapes, correlating with chronological age, which paves the way to study further the impact of epigenetic factors on flowering in moso bamboo.

10.
Phys Chem Chem Phys ; 23(4): 3135-3143, 2021 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-33491712

RESUMO

Molecular dynamics simulations combined with periodic electronic structure calculations are performed to decipher structural, thermodynamical and dynamical properties of the interfaced vs. confined water adsorbed in hexagonal 1D channels of the 2D layered electrically conductive Cu3(HHTP)2 and Cu3(HTTP)2 metal-organic frameworks (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene and HTTP = 2,3,6,7,10,11-hexathiotriphenylene). Comparing water adsorption in bulk vs. slab models of the studied 2D MOFs shows that water is preferentially adsorbed on the framework walls via forming hydrogen bonds to the organic linkers rather than by coordinating to the coordinatively unsaturated open-Cu2+ sites. Theory predicts that in Cu3(HTTP)2 the van der Waals interactions are stronger which helps the MOF maintain its layered morphology with allowing very little water molecules to diffuse into the interlayer space. Data presented in this work are general and helpful in implementing new strategies for preserving the integrity as well as electrical conductivity of porous materials in aqueous solutions.

11.
Phys Med Biol ; 66(4): 045023, 2021 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-33361574

RESUMO

PURPOSE: To investigate the impact of 4D-CBCT image quality on radiomic analysis and the efficacy of using deep learning based image enhancement to improve the accuracy of radiomic features of 4D-CBCT. MATERIAL AND METHODS: In this study, 4D-CT data from 16 lung cancer patients were obtained. Digitally reconstructed radiographs (DRRs) were simulated from the 4D-CT, and then used to reconstruct 4D CBCT using the conventional FDK (Feldkamp et al 1984 J. Opt. Soc. Am. A 1 612-9) algorithm. Different projection numbers (i.e. 72, 120, 144, 180) and projection angle distributions (i.e. evenly distributed and unevenly distributed using angles from real 4D-CBCT scans) were simulated to generate the corresponding 4D-CBCT. A deep learning model (TecoGAN) was trained on 10 patients and validated on 3 patients to enhance the 4D-CBCT image quality to match with the corresponding ground-truth 4D-CT. The remaining 3 patients with different tumor sizes were used for testing. The radiomic features in 6 different categories, including histogram, GLCM, GLRLM, GLSZM, NGTDM, and wavelet, were extracted from the gross tumor volumes of each phase of original 4D-CBCT, enhanced 4D-CBCT, and 4D-CT. The radiomic features in 4D-CT were used as the ground-truth to evaluate the errors of the radiomic features in the original 4D-CBCT and enhanced 4D-CBCT. Errors in the original 4D-CBCT demonstrated the impact of image quality on radiomic features. Comparison between errors in the original 4D-CBCT and enhanced 4D-CBCT demonstrated the efficacy of using deep learning to improve the radiomic feature accuracy. RESULTS: 4D-CBCT image quality can substantially affect the accuracy of the radiomic features, and the degree of impact is feature-dependent. The deep learning model was able to enhance the anatomical details and edge information in the 4D-CBCT as well as removing other image artifacts. This enhancement of image quality resulted in reduced errors for most radiomic features. The average reduction of radiomics errors for 3 patients are 20.0%, 31.4%, 36.7%, 50.0%, 33.6% and 11.3% for histogram, GLCM, GLRLM, GLSZM, NGTDM and Wavelet features. And the error reduction was more significant for patients with larger tumors. The findings were consistent across different respiratory phases, projection numbers, and angle distributions. CONCLUSIONS: The study demonstrated that 4D-CBCT image quality has a significant impact on the radiomic analysis. The deep learning-based augmentation technique proved to be an effective approach to enhance 4D-CBCT image quality to improve the accuracy of radiomic analysis.

12.
Angle Orthod ; 2020 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-33289807

RESUMO

OBJECTIVES: To compare the transfer accuracy of two digital transfer trays, the three-dimensional printed (3D printed) tray and the vacuum-formed tray, in the indirect bonding of labial brackets. MATERIALS AND METHODS: Ten digital dental models were constructed by oral scans using an optical scanning system. 3D printed trays and vacuum-formed trays were obtained through the 3Shape indirect bonding system and rapid prototyping technology (10 in each group). Then labial brackets were transferred to 3D printed models, and the models with final bracket positioning were scanned. Linear (mesiodistal, vertical, buccolingual) and angular (angulation, torque, rotation) transfer errors were measured using GOM Inspect software. The mean transfer errors and prevalence of clinically acceptable errors (linear errors of ≤0.5 mm and angular errors of ≤2°) of two digital trays were compared using the Mann-Whitney U-test and the Chi-square test, respectively. RESULTS: The 3D printed tray had a lower mean mesiodistal transfer error (P < .01) and a higher prevalence of rotation error within the limit of 2° (P = .03) than did the vacuum-formed tray. Linear errors within 0.5 mm were higher than 90% for both groups, while torque errors within 2° were lowest at 50.9% and 52.9% for the 3D printed tray and vacuum-formed tray, respectively. Both groups had a directional bias toward the occlusal, mesial, and buccal. CONCLUSIONS: The 3D printed tray generally scored better in terms of transfer accuracy than did the vacuum-formed tray. Both types of trays had better linear control than angular control of brackets.

13.
Chemistry ; 2020 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-33270953

RESUMO

Theoretical studies have disclosed that the surface terminations such as MAI- or PbI-layers affect greatly on the environmental stability of organic-inorganic perovskite. However, until now, there have been rarely direct evidence trying to experimentally detect the existence of MAI or PbI terminations on MAPbI3 grains, let along disclosing their effects on the humidity degradation pathway of perovskite solar cell. Here, we successfully modified and detected the surface terminations of MAI and PbI species on the polycrystalline MAPbI3 films. For the MAI-terminated perovskite film, it followed the moisture degradation process from MAPbI3 to hydrate MAPbI3·H2O and then into PbI2, penetration of water molecules was the main driving force to lead the degradation of MAPbI3 layer by layer. While, for the PbI-terminated perovskite film in humidity, a deprotonation degradation pathway was confirmed, in which it preferred to directly degrade from MAPbI3 into PbI2, while the iodine defects here played a key role in promoting the dissociation of water molecules into hydroxyl OH- and further catalyzing the decomposition of perovskite.

14.
Chem Commun (Camb) ; 2020 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-33332494

RESUMO

A combined quantum mechanics and classical molecular dynamics approach is used to unravel the effects of structural deformations and heterogeneity on catalytic activity of 2D π-stacked layered metal-organic frameworks. Theory predicts that the flexible nature of these materials creates a complex array of catalytically active sites for oxidative dehydrogenation of propane. Using an ensemble approach and oxygen bond formation energy, as an excellent probe, we investigate the catalytic activity down to the single active site level.

15.
Head Neck ; 2020 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-33247492

RESUMO

BACKGROUND: Currently, no randomized controlled trial has been performed to investigate the safety profiles, economic benefit and mental health of ambulatory thyroidectomy in patients with papillary thyroid carcinoma (PTC). METHODS: Patients diagnosed with PTC were enrolled in this study and were randomly assigned to ambulatory group and control group. The safety profiles, economic benefit and mental health were investigated. RESULTS: Four hundred and eleven patients completed the study. There was no significant difference in demographic or tumor index. The incidence of complications was not significantly different (P = .631). The economic cost was significantly lower (P < .001) and hospitalization was significantly shorter (P < .001) in ambulatory group. No significant difference was shown in depression (P = .758) and stress disorder (P = .390). However, the ambulatory group showed a higher point of anxiety (P < .001). CONCLUSION: The ambulatory thyroidectomy is safe in patients with PTC, with significant benefits of economic cost and hospitalization.

16.
ACS Sens ; 2020 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-33253540

RESUMO

Luminescence lifetime-based nanosensors for chloride ions were designed by incorporating a luminescent ruthenium dye [Ru(1,10-phenanthroline)3] inside silica nanoparticles and chemically labelling their outer surface with chloride ion-sensitive fluorescent dyes (N,N'-bis(carboxypropyl)-9,9'-biacridine). The nanosensor surface was further functionalized with positively charged amino groups to facilitate intracellular uptake via endocytosis and target lysosomes. The nanosensors have an average diameter of 52 nm and are monodispersed in aqueous solutions. Because of the long lifetime of the reference ruthenium dye, the sensor response can be analyzed using the time-domain dual-lifetime referencing (td-DLR) approach. The use of pulsed excitation in td-DLR rather than intense continuous illumination in ratiometric measurements greatly prevents the dye from photobleaching which significantly improves its measurement stability and reproducibility for long-term monitoring. At optimum conditions, the sensor can measure chloride concentration in the range of 0-200 mM with a large ratiometric signal change from 140.9 to 40.2. Combined with our custom-built microscopic td-DLR system, variations of intracellular chloride concentration in lysosomes were imaged quantitatively with a high spatial resolution and accuracy.

17.
Org Lett ; 22(22): 9029-9035, 2020 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-33176097

RESUMO

A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal ß-trifluoroethylated enamides bearing a diverse range of functional groups.

18.
Nanomaterials (Basel) ; 10(11)2020 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-33143281

RESUMO

We study the ultrafast photoexcitation dynamics in PBDTTT-C-T (P51, poly(4,8-bis(5-(2-ethylhexyl)-thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene-alt-alkylcarbonyl-thieno[3,4-b]thiophene)) film (~100 nm thickness) and PBDTTT-C-T:PC71BM (P51:PC71BM, phenyl-C71-butyric-acid-methyl ester) nanostructured blend (∼100 nm thickness) with/without DIO(1,8-diiodooctane) additives with sub-10 fs transient absorption (TA). It is revealed that hot-exciton dissociation and vibrational relaxation could occur in P51 with a lifetime of ~160 fs and was hardly affected by DIO. However, the introduction of DIO in P51 brings a longer lifetime of polaron pairs, which could make a contribution to photocarrier generation. In P51:PC71BM nanostructured blends, DIO could promote the Charge Transfer (CT) excitons and free charges generation with a ~5% increasement in ~100 fs. Moreover, the dissociation of CT excitons is faster with DIO, showing a ~5% growth within 1 ps. The promotion of CT excitons and free charge generation by DIO additive is closely related with active layer nanomorphology, accounting for Jsc enhancement. These results reveal the effect of DIO on carrier generation and separation, providing an effective route to improve the efficiency of nanoscale polymer solar cells.

19.
J Hum Genet ; 2020 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-33177701

RESUMO

Mutual exclusivity analyses provide an effective tool to identify driver genes from passenger genes for cancer studies. Various algorithms have been developed for the detection of mutual exclusivity, but controlling false positive and improving accuracy remain challenging. We propose a forward selection algorithm for identification of mutually exclusive gene sets (FSME) in this paper. The method includes an initial search of seed pair of mutually exclusive (ME) genes and subsequently including more genes into the current ME set. Simulations demonstrated that, compared to recently published approaches (i.e., CoMEt, WExT, and MEGSA), FSME could provide higher precision or recall rate to identify ME gene sets, and had superior control of false positive rates. With application to TCGA real data sets for AML, BRCA, and GBM, we confirmed that FSME can be utilized to discover cancer driver genes.

20.
World J Surg Oncol ; 18(1): 272, 2020 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-33097053

RESUMO

INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) stands as the second most common malignant tumor in the liver with poor patient prognosis. Increasing evidences have shown that inflammation plays a significant role in tumor progression, angiogenesis, and metastasis. However, the prognosis significance of inflammatory biomarkers on recurrence-free survival (RFS) and overall survival (OS) in ICC patients is poorly recognized. METHODS: ICC patients who underwent curative hepatectomy and diagnosed pathologically were retrospectively analyzed. Inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), were investigated. RESULTS: Receiver operating characteristic (ROC) curves showed no significance in NLR, PLR, and LMR in RFS and OS, while significant results were shown on SII in both RFS (P = 0.035) and OS (P = 0.034) with areas under ROC curve as 0.63 (95%CI 0.52-0.74) and 0.62 (95%CI 0.51-0.72), respectively. Kaplan-Meier curves revealed a statistically significant better survival data in SII-low groups on both RFS (P < 0.001) and OS (P < 0.001). The univariate and multivariate analyses revealed that higher level of SII was independently associated with both poorer RFS time and OS time. However, no significant result was shown on NLR, PLR, or LMR. CONCLUSION: SII is an effective prognostic factor for predicting the prognosis of ICC patient undergone curative hepatectomy, while NLR, PLR, and LMR are not associated with clinical outcomes of these patients.

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