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1.
Plant Dis ; 2021 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-33934629

RESUMO

The necrotrophic pathogen Sclerotinia sclerotiorum is one of the most damaging and economically important plant pathogens. Pydiflumetofen, which was recently developed by Syngenta Crop Protection, has already been registered in China for the management of Sclerotinia stem rot (SSR) which was caused by S. sclerotiorum in oilseed rape. In an attempt to preempt and forestall the development of resistance to this useful fungicide, the current study was initiated to investigate potential mechanism of resistance in laboratory mutants. Five pydiflumetofen-resistant S. sclerotiorum mutants were successfully generated by repeated exposure to the fungicide under laboratory conditions. Although the mutants had greatly reduced sensitivity to pydiflumetofen, they were also found to have significantly (p < 0.05) reduced fitness exhibiting reduced mycelial growth and sclerotia formation on PDA medium. However, three of the four mutants had significantly (p < 0.05) increased pathogenicity on detached soybean leaves compared to their respective parental isolates, indicating a moderate to high level of fungicides resistance risk according to the criteria of Fungicide Resistance Action Committee (FRAC). Sequence analysis of four succinate dehydrogenase (Sdh) target genes identified several nucleotide changes in the sequences of the pydiflumetofen-resistant mutants, most of which were synonymous and caused no changes to the predicted amino acid sequences. However, all of the pydiflumetofen-resistant mutants had two amino acid point mutations (A11V and V162A) in their predicted SsSdhB sequence. No similar changes were found in the SsSdhA, SsSdhC, and SsSdhD genes of any of the mutants tested. In addition, there was a positive cross-resistance between pydiflumetofen and boscalid, and no cross-resistance between pydiflumetofen and other commonly used fungicides, including tebuconazole, fludioxonil, cyprodinil, dimethachlone, prochloraz, pyraclostrobin, fluazinam, procymidone, and carbendazim. These results indicate that pydiflumetofen has great potential as an alternative fungicide for the control of S. sclerotiorum, especially where resistance to other fungicides has already emerged. Mixing or alternate application with fludioxonil, prochloraz, and fluazinam could be used to limit the risk of resistance to pydiflumetofen.

3.
Epilepsy Behav ; 118: 107957, 2021 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-33872942

RESUMO

BACKGROUND: Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) has been proved to be a safe method to reduce seizure frequency in patients with drug-resistant epilepsy. However, there are few reports addressing the value and safety of this procedure in hypothalamic hamartoma (HH). OBJECTIVE: To present the results of our experience using SEEG-guided RFTC in HH patients with drug-resistant epilepsy, and identify outcome predictors. METHODS: We retrospectively reviewed the clinical and surgical characteristics of 27 HH-related patients with epilepsy in our center between 2015 and 2019. All patients underwent invasive recordings with SEEG before RFTC was performed. We reported surgical outcome predictors and postoperative follow-up concerning safety and efficacy (mean follow-up, 27.3 months; range, 12-63). Surgical strategy was also analyzed. RESULTS: Nineteen patients (70.4%) achieved Engel's class I outcome, while 4 patients (14.8%) did not show significant improvement. Of all observed seizures, two different onset patterns of intracranial electrophysiology recorded by SEEG were observed. Patients presented with focal low-voltage fast activity were more likely to obtain seizure freedom (p = 0.045), while classification (p = 0.478), volume (p = 0.546), history of resection (p = 0.713), seizure types (p = 0.859), or seizure duration (p = 0.415) showed no significant effect on the outcome. Weight gain was the most common long-term complication (18.5%). CONCLUSION: The SEEG can guide the ablation of HH and serve as an important factor to predict favorable seizure outcomes. Radiofrequency thermocoagulation guided by SEEG can offer a minimally invasive and low-risk surgical approach with excellent outcomes. Disconnecting the attachment of HH should be the appropriate strategy to obtain the best seizure outcome.

4.
Nanoscale ; 2021 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-33885113

RESUMO

Most materials that feature nontrivial band topology are spin-degenerate and three dimensional, strongly restricting them from application in spintronic nanodevices. Hence, two-dimensional (2D) intrinsically spin-polarized systems with rich topological elements are still in extreme scarcity. Here, 2D A3C2 (A = Ti, Zr, and Hf) materials with the P6[combining macron]m2 type structure are reported as new ferromagnetic materials with intrinsic magnetism and good stability. Unlike the Weyl nodal lines existing in nonmagnetic 2D systems, A3C2 hosts time-reversal-breaking Weyl nodal rings (two Γ-centered, one K-centered, and one K'-centered) without spin-orbit coupling (SOC). These nodal rings still remained under SOC with magnetization along the z direction (easy magnetization axis). More interestingly, the Curie temperatures (TC) of A3C2 were determined based on the Monte Carlo simulation. Ti3C2 features an extraordinary TC (above 800 K), and those of Zr3C2 and Hf3C2 are above room temperature. Therefore, A3C2 materials are excellent platforms to study magnetic Weyl nodal lines in high TC ferromagnetic 2D materials.

5.
Artigo em Inglês | MEDLINE | ID: mdl-33929595

RESUMO

L-tert-leucine (L-Tle) is widely used as vital chiral intermediate for pharmaceuticals and as chiral auxiliarie for organocatalysis. L-Tle is generally prepared via the asymmetric reduction of trimethylpyruvate (TMP) catalyzed by NAD+-dependent leucine dehydrogenase (LeuDH). To improve the catalytic efficiency and coenzyme affinity of LeuDH from Bacillus cereus, mutation libraries constructed by error-prone PCR and iterative saturation mutation were screened by two kinds of high-throughput methods. Compared with the wild type, the affinity of the selected mutant E24V/E116V for TMP and NADH increased by 7.7- and 2.8-fold, respectively. And the kcat/Km of E24V/E116V on TMP was 5.4-fold higher than that of the wild type. A coupled reaction comprising LeuDH with glucose dehydrogenase of Bacillus amyloliquefaciens resulted in substrate inhibition at high TMP concentrations (0.5 M), which was overcome by batch-feeding of the TMP substrate. The total turnover number and specific space-time conversion of 0.57 M substrate increased to 11,400 and 22.8 mmol·h-1·L-1·g-1, respectively. KEY POINTS: • The constructed new high-throughput screening strategy takes into account the two indicators of catalytic efficiency and coenzyme affinity. • A more efficient leucine dehydrogenase (LeuDH) mutant (E24V/E116V) was identified. • E24V/E116V has potential for the industrial synthesis of L-tert-leucine.

6.
Environ Res ; 197: 111129, 2021 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-33839116

RESUMO

The production of hydroxyl radicals has been demonstrated to improve the antifouling of marine through a photocatalytic strategy. However, only relying on the valence band of the photocatalyst to generate hydroxyl radicals is inefficient and limits the application of photocatalytic technology in the field of marine-antifouling coatings. Herein, we reported a new strategy in which Ag quantum dots are used to synthesize hydrogen peroxide (H2O2) by photocatalysis in seawater. The decomposition of the generated H2O2 to hydroxyl radicals improves the antifouling ability. Interestingly, the prominent size effect of Ag quantum dots is closely related to the yield of H2O2. We synthesized Ag quantum dots supported on ZnO and found that Ag quantum dots approximately 4 nm in size have the highest activity for H2O2 generation and undergo a 1 h photocatalytic reaction in which the concentration of H2O2 can reach 124 µg/mL. The efficiency of ZnO in inactivating marine microorganisms increased from 72.3% to 99.4% in seawater. The synthesis of H2O2 through photocatalysis based on the medium of seawater can expand the application of photocatalytic technology in the field of marine antifouling.

7.
Environ Res ; 197: 111167, 2021 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-33861976

RESUMO

The use of solar energy to decompose seawater and produce hydrogen is of great significance in solving the energy crisis. Numerous studies have shown that vacancies can significantly improve photocatalytic activity due to their electron-rich nature. However, our recent research has shown that materials with vacancies are not suitable for photocatalytic reactions in seawater. In this study, g-C3N4 with rich N vacancies was selected as the research object, and urea was used as the precursor; in this system, the N vacancies in g-C3N4 could be effectively reduced by the addition of ZIF-8 (ZCNQx). The activity of ZCNQ40 was 5.6 times higher than that of g-C3N4 in fresh seawater, but only 3.1 times higher in freshwater. Based on the analysis of the experimental results, we believe that g-C3N4 has a limiting relationship between H+ adsorption catalysis and H2 product desorption. In addition, seawater contains many heteroatoms that will also compete with proton (H+) reduction. The results of our study show that catalysts with vacancies are not necessarily suitable for catalytic reactions in seawater media. This research will stimulate new ideas for research into the conversion of solar energy to chemical energy in seawater media.

8.
Environ Pollut ; 283: 117122, 2021 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-33872939

RESUMO

Rice field has been traditionally considered as a nonpoint source of reactive nitrogen (N) for the environment, while it, with surrounding ditches and ponds, also contributes to receiving N inputs from atmosphere and waterbodies and intercepting N outputs from rice field. However, a comprehensive assessment of the N source or sink of rice field for the environment is lacking. Here, we conducted the 3-year systematic observations and process-based simulations of N budget at the Jingzhou site in Central China. We identified the roles of rice field and evaluated the opportunities for shifting its role from N source (i.e., outputs > inputs) to sink (i.e., outputs ≤ inputs). Rice field was found to be a N source of 24.2-28.7 kg N ha-1 for waterbodies (including surface and ground waters), but a N sink (2.2-8.8 kg N ha-1) for the atmosphere for the wet and normal year climatic scenarios. The "4R-nutrient stewardship" (i.e., using the right type of N fertilizers, at right rate, right time, and in right place) applied in rice field was sufficient for the source-to-sink shift for the atmosphere for dry year climatic scenario, but needed to implement together with improvements of irrigation and drainage for waterbodies. Furthermore, with the combination of these improved management technologies, rice field played a role as a N sink of up to 22.8 kg N ha-1 for the atmosphere and up to 2.0 kg N ha-1 for waterbodies, along with 24% decrease in irrigation water use and 21% decrease in N application rate without affecting rice yield and soil fertility. Together these findings highlight a possibility to achieve an environmental-friendly rice field by improving agricultural management technologies.

9.
Artigo em Inglês | MEDLINE | ID: mdl-33894423

RESUMO

BACKGROUND: Overarching conceptualizations propose that the complex social-emotional effects of oxytocin (OXT) in humans are partly mediated by interactions with other neurotransmitter systems. Recent animal models suggest that the anxiolytic effects of OXT are critically mediated by the serotonin (5-HT) system, yet direct evidence in humans is lacking. METHODS: To determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, we conducted a parallel-group randomized placebo-controlled double-blind experiment during which n = 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD+) or the corresponding placebo-control protocols before the administration of intranasal OXT or placebo intranasal spray, respectively. Mean and repetition-dependent changes in threat-specific amygdala reactivity towards threatening stimuli (angry faces) as assessed by fMRI served as the primary outcome. RESULTS: No treatment main or interaction effects on amygdala threat reactivity were observed, yet OXT switched bilateral amygdala threat sensitization to desensitization and this effect was significantly attenuated during decreased central 5-HT signaling via pretreatment with ATD+ CONCLUSIONS: The present findings provide the first evidence for a role of OXT in threat-specific amygdala desensitization in humans and suggest that these effects are critically mediated by the 5-HT system. OXT may have a therapeutic potential to facilitate amygdala desensitization and adjunct up-regulation of 5-HT neurotransmission may facilitate OXT's anxiolytic potential.

10.
Int J Biol Sci ; 17(5): 1395-1412, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33867854

RESUMO

Mechanical loading can induce or antagonize the extracellular matrix (ECM) synthesis, proliferation, migration, and inflammatory responses of annulus fibrosus cells (AFCs), depending on the loading mode and level. Caveolin-1 (Cav1), the core protein of caveolae, plays an important role in cellular mechanotransduction and inflammatory responses. In the present study, we presented that AFCs demonstrated different behaviors when subjected to cyclic tensile strain (CTS) for 24 h at a magnitude of 0%, 2%, 5% and 12%, respectively. It was found that 5% CTS had positive effects on cell proliferation, migration and anabolism, while 12% CTS had the opposite effects. Besides, cells exposed to interleukin-1ß stimulus exhibited an increase expression in inflammatory genes, and the expression of these genes decreased after exposure to moderate mechanical loading with 5% CTS. In addition, 5% CTS decreased the level of Cav1 and integrin ß1 and exhibited anti-inflammatory effects. Moreover, the expression of integrin ß1 and p-p65 increased in AFCs transfected with Cav1 plasmids. In vivo results revealed that moderate mechanical stimulation could recover the water content and morphology of the discs. In conclusion, moderate mechanical stimulation restrained Cav1-mediated signaling pathway and exhibited anti-inflammatory effects on AFCs. Together with in vivo results, this study expounds the underlying molecular mechanisms on the effect of moderate mechanical stimulation on intervertebral discs (IVDs) and may provide a new therapeutic strategy for the treatment of IVD degeneration.

11.
Nanomaterials (Basel) ; 11(3)2021 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-33803460

RESUMO

A simple and effective approach based on the liquid phase exfoliation (LPE) method has been put forward for synthesizing boron quantum dots (BQDs). By adjusting the interactions between bulk boron and various solvents, the average diameter of produced BQDs is about 7 nm. The nonlinear absorption (NLA) responses of as-prepared BQDs have been systematically studied at 515 nm and 1030 nm. Experimental results prove that BQDs possess broadband saturable absorption (SA) and good third-order nonlinear optical susceptibility, which are comparable to graphene. The fast relaxation time and slow relaxation time of BQDs at 515 nm and 1030 nm are about 0.394-5.34 ps and 4.45-115 ps, respectively. The significant ultrafast nonlinear optical properties can be used in optical devices. Here, we successfully demonstrate all-optical diode application based on BQDs/ReS2 tandem structure. The findings are essential for understanding the nonlinear optical properties in BQDs and open a new pathway for their applications in optical devices.

12.
Autism Res ; 2021 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-33908177

RESUMO

While several functional and structural changes occur in large-scale brain networks in autism spectrum disorder (ASD), reduced interhemispheric resting-state functional connectivity (rsFC) between homotopic regions may be of particular importance as a biomarker. ASD is an early-onset developmental disorder and neural alterations are often age-dependent. Although there is some evidence for homotopic interhemispheric rsFC alterations in language processing regions in ASD children, wider analyses using large data sets have not been performed. The present study, therefore, conducted a voxel-based homotopic interhemispheric rsFC analysis in 146 ASD and 175 typically developing children under-age 10 and examined associations with symptom severity in the autism brain imaging data exchange data sets. Given the role of corpus callosum (CC) in interhemispheric connectivity and reported CC volume changes in ASD we additionally examined whether there were parallel volumetric changes. Results demonstrated decreased homotopic rsFC in ASD children in the posterior cingulate cortex (PCC) and precuneus of the default mode network, the precentral gyrus of the mirror neuron system, and the caudate of the reward system. Homotopic rsFC of the PCC was associated with symptom severity. Furthermore, although no significant CC volume changes were found in ASD children, there was a significant negative correlation between the anterior CC volumes and homotopic rsFC strengths in the caudate. The present study shows that a reduced pattern of homotopic interhemispheric rsFC in ASD adults/adolescents is already present in children of 5-10 years old and further supports their potential use as a general ASD biomarker. LAY SUMMARY: Homotopic interhemispheric functional connectivity plays an important role in synchronizing activity between the two hemispheres and is altered in adults and adolescents with autism spectrum disorder (ASD). In the present study focused on children with ASD, we have observed a similar pattern of decreased homotopic connectivity, suggesting that alterations in homotopic interhemispheric connectivity may occur early in ASD and be a useful general biomarker across ages.

13.
Neuroimage Clin ; 30: 102661, 2021 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-33866301

RESUMO

Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are highly debilitating and often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral and neurofunctional level. The determination of disorder-specific behavioral and neurofunctional dysregulations may therefore promote neuro-mechanistic and diagnostic specificity. In order to determine disorder-specific alterations in the domain of emotion-cognition interactions the present study examined emotional context-specific inhibitory control in treatment-naïve MDD (n = 37) and GAD (n = 35) patients and healthy controls (n = 35). On the behavioral level MDD but not GAD exhibited impaired inhibitory control irrespective of emotional context. On the neural level, MDD-specific attenuated recruitment of inferior/medial parietal, posterior frontal, and mid-cingulate regions during inhibitory control were found during the negative context. GAD exhibited a stronger engagement of the left dorsolateral prefrontal cortex relative to MDD. Overall the findings from the present study suggest disorder- and emotional context-specific behavioral and neurofunctional inhibitory control dysregulations in major depression and may point to a depression-specific neuropathological and diagnostic marker.

14.
Nat Commun ; 12(1): 2339, 2021 04 20.
Artigo em Inglês | MEDLINE | ID: mdl-33879783

RESUMO

Developing organic photoluminescent materials with high emission efficiencies in the solid state under a water atmosphere is important for practical applications. Herein, we report the formation of both intra- and intermolecular hydrogen bonds in three tautomerizable Schiff-base molecules which comprise active hydrogen atoms that act as proton donors and acceptors, simultaneously hindering emission properties. The intercalation of water molecules into their crystal lattices leads to structural rearrangement and organic hydrate luminogen formation in the crystalline phase, triggering significantly enhanced fluorescence emission. By suppressing hydrogen atom shuttling between two nitrogen atoms in the benzimidazole ring, water molecules act as hydrogen bond donors to alter the electronic transition of the molecular keto form from nπ* to lower-energy ππ* in the excited state, leading to enhancing emission from the keto form. Furthermore, the keto-state emission can be enhanced using deuterium oxide (D2O) owing to isotope effects, providing a new opportunity for detecting and quantifying D2O.

15.
BMC Genomics ; 22(1): 257, 2021 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-33838645

RESUMO

BACKGROUND: Non-Drosophila insects provide diverse aging types and important complementary systems for studies of aging biology. However, little attention has been paid to the special roles of non-Drosophila insects in aging research. Here, the aging-related features of the migratory locust, Locusta migratoria, were determined at the physiological, cellular, and transcriptional levels. RESULTS: In physiological assessments, the flight performance and sperm state of locusts displayed clear aging-related decline in male adults. Transcriptional analyses demonstrated locusts have similar aging-related genes with model species. However, different from those of Drosophila and mammals, the organ-specific aging transcriptional features of locusts were characterized by intensive expression changes in flight muscle and fat body and little transcriptional changes in brain. The predominant transcriptional characteristics of flight muscle and fat body aging were changes in expression of mitochondrion-related genes and detoxification and phagocytosis genes, respectively. Cellular assessments revealed the incidence of mitochondrial abnormalities significantly increased in aged flight muscle, and apoptotic signals and nuclear abnormalities were enhanced in aged fat body but not in brain. In addition, some well-known aging genes and locust aging-related genes (i.e., IAP1, PGRP-SA, and LIPT1), whose roles in aging regulation were rarely reported, were demonstrated to affect lifespan, metabolism, and flight ability of locusts after RNAi. CONCLUSION: This study revealed multi-level aging signatures of locust, thus laying a foundation for further investigation of aging mechanisms in this famous insect in the future.

16.
Funct Plant Biol ; 2021 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-33820601

RESUMO

Herbicides are the major tool for controlling large populations of yield depleting weeds. However, over-reliance on herbicides has resulted in weed adaptation and herbicide resistance. In recent years, early flowering weed species related to herbicide resistance is emerging, which may cause seed loss before crop harvest, creating a new problem for non-chemical weed management. In this study, a homologue gene of AGAMOUS sub-family (referred to as PfAG5) of the MADS-box family was cloned from plants of an early flowering Polypogon fugax Nees ex Steud. population resistant to the ACCase inhibitor herbicide (clodinafop-propargyl). The PfAG5 gene was functionally characterised in Arabidopsis thaliana L. Overexpression of the PfAG5 gene in Arabidopsis resulted in early flowering, abnormal flowers (e.g. small petals), short plants and reduced seed set, compared with the wild type. The expression of the PfAG5 gene was high in leaves and flowers, but low in pods in transgenic Arabidopsis. The PfAG5 gene was expressed earlier and higher in the resistant (R) than the susceptible (S) P. fugax plants. Furthermore, one protein (FRIGIDA-like) with relevance to flowering time regulation and interacts with PfAG5 in resistant (R) P. fugax was identified by the yeast two-hybrid and pull-down assays. These results suggest that the PfAG5 gene is involved in modulating early flowering in P. fugax.

18.
Curr Med Res Opin ; : 1-11, 2021 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-33729889

RESUMO

BACKGROUND: To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources. METHODS: 6415 patients from seven hospitals in Wuhan city were assigned to the training and testing cohorts. A total of 6351 patients from another three hospitals in Wuhan, 2169 patients from outside of Wuhan, and 553 patients from Milan, Italy were assigned to three independent validation cohorts. A total of 64 candidate clinical variables at hospital admission were analyzed by random forest and least absolute shrinkage and selection operator (LASSO) analyses. RESULTS: Eight factors, namely, Oxygen saturation, blood Urea nitrogen, Respiratory rate, admission before the date the national Maximum number of daily new cases was reached, Age, Procalcitonin, C-reactive protein (CRP), and absolute Neutrophil counts, were identified as having significant associations with mortality in COVID-19 patients. A composite score based on these eight risk factors, termed the OURMAPCN-score, predicted the risk of mortality among the COVID-19 patients, with a C-statistic of 0.92 (95% confidence interval [CI] 0.90-0.93). The hazard ratio for all-cause mortality between patients with OURMAPCN-score >11 compared with those with scores ≤ 11 was 18.18 (95% CI 13.93-23.71; p < .0001). The predictive performance, specificity, and sensitivity of the score were validated in three independent cohorts. CONCLUSIONS: The OURMAPCN score is a risk assessment tool to determine the mortality rate in COVID-19 patients based on a limited number of baseline parameters. This tool can assist physicians in optimizing the clinical management of COVID-19 patients with limited hospital resources.

19.
Environ Toxicol ; 36(6): 1226-1242, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33665894

RESUMO

Di-(2-ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine-disrupting chemical (EDC) that has been shown to disrupt the function of reproductive system in females. Although many studies have shown that DEHP potentially causes female reproductive toxicity, including depletion of the primordial follicle and decreased sex hormone production, the specific mechanisms by which DEHP affects female reproduction remain unknown. In recent years, research focused on the intestinal flora has provided an idea to eliminate our confusion, and gut bacterial dysbiosis may contribute to female reproductive toxicity. In the present study, the feces of DEHP-exposed mice were collected and analyzed using 16S rRNA amplicon sequencing and untargeted global metabolite profiling of metabolomics. DEHP obviously causes reproductive toxicity, including the ovarian organ coefficient, estradiol level, histological features of the ovary and estrus. Furthermore, DEHP exposure alters the structure of the intestinal microbiota community and fecal metabolite profile in mice, suggesting that the reproductive toxicity may be caused by gut bacterial dysbiosis and altered metabolites, such as changes in the levels of short-chain fatty acid (SCFA). Additionally, it is well known that changes in gut microbiota and fecal metabolites cause inflammation and tissue oxidative stress, expectedly, we found oxidative stress in the ovary and systemic inflammation in DEHP exposed mice. Thus, based on our findings, DEHP exposure may cause gut bacterial dysbiosis and altered metabolite profiles, particularly SCFA profiles, leading to oxidative stress in the ovary and systemic inflammation to ultimately induce female reproductive toxicity.


Assuntos
Dietilexilftalato , Microbioma Gastrointestinal , Animais , Dietilexilftalato/toxicidade , Fezes , Feminino , Camundongos , Ácidos Ftálicos , RNA Ribossômico 16S , Reprodução
20.
Huan Jing Ke Xue ; 42(2): 874-882, 2021 Feb 08.
Artigo em Chinês | MEDLINE | ID: mdl-33742882

RESUMO

A novel biochar was prepared by modification with corn straw, ethylene triamine, and carbon disulfide, and its adsorption properties and stability with respect to heavy metal ions in single and mixed systems (Pb2+, Ni2+, and Cd2+) were investigated. Characterization analysis confirmed the successful modification of an amine-sulfur double group on the surface of the biochar, which had abundant functional groups with a large specific surface area. Adsorption experiments under the single system indicated that the adsorption equilibrium time was 4 h and the optimum dosages were 1, 0.8, and 1.2 g·L-1. The adsorption met the conditions of the quasi-second-order kinetic equation. Under the ternary system, the adsorption equilibrium time was reduced to 1.5 h, the optimum dosages were 0.4, 1.6, and 0.8 g·L-1, and the adsorption sequence was Pb2+ > Cd2+ > Ni2+. The total amount of adsorption was 0.67 mmol·g-1, which was higher than that of single heavy metal ions, indicating that amine-sulfur modified straw biochar (BC-SN) has an improved treatment effect on polluted water under the coexistence of three heavy metal ions. The Pb2+ and Cd2+ adsorbed by the biochar was stably bound in the form of heavy metal sulfide and a chelated amino group. In contrast, the adsorption of Ni2+ was via the mixed adsorption of various functional groups. When Pb2+ and Cd2+ compete for adsorption, the binding energy is higher and adsorption stability is more reliable.

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