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1.
J Card Surg ; 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36047383

RESUMO

OBJECTIVE: This study aimed to detect the predictors of vein graft disease (VGD) progression between 1 week and 1 year after surgery and to evaluate the impact of secondary prevention medications. METHODS: A total of 218 consecutive patients underwent surgical coronary revascularization were evaluated by coronary computed tomography angiography both at 1-week and 1-year follow-up. Logistic regression analyses were performed to investigate the predictors of VGD progression. A risk score (0-4) was set up to evaluate implementation result of secondary prevention measures according to 1-year follow-up result. Association between VGD progression and the risk score was assessed. RESULTS: VGD progression occurred in 11.3% of saphenous vein grafts (SVG) and 22.1% of patients. At the patient level, poor vein graft (odds ratio [OR] = 4.25), noncontrolled hyperlipidemia (OR = 3.01), and diabetes mellitus (DM) (OR = 2.96) were predictors, while diameter of SVG (mm, OR = 0.35) was protective factor. At the graft level, DM (OR = 3.52), noncontrolled hyperlipidemia (OR = 2.33), and peripheral artery disease (PAD) (OR = 2.20) were predictors, while number of SVGs (OR = 0.63), diameter of SVG (mm, OR = 0.39), and mean graft flow >25 ml/min (OR = 0.35) were protective factors. VGD progression was significantly associated with the risk score at both the patient (OR = 1.52) and the graft level (OR = 1.38). CONCLUSIONS: Poor vein graft, noncontrolled hyperlipidemia and DM were predictors of VGD progression between 1 week and 1 year after surgery at the patient level, while larger SVG diameter was a protective factor. DM, PAD and noncontrolled hyperlipidemia were predictors at the graft level, while a number of SVGs, larger SVG diameter, and mean graft flow >25 ml/min were protective factors. Implementation failure of secondary prevention medications was associated with VGD progression from as early as 1 year after surgery.

2.
BMC Urol ; 22(1): 140, 2022 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-36057571

RESUMO

BACKGROUND: Drainage is indicated in many patients with a perinephric abscess (PA). Surgical drainage is associated with trauma and slow recovery, while percutaneous drainage can be ineffective in some patients. We report on 11 patients with PA treated by percutaneous nephroscopy combined with ultrasound-guided negative-pressure suction under local anesthesia. METHODS: This case series included 11 PA patients operated on from January 2013 to June 2020. All patients received percutaneous nephroscopy combined with ultrasound-guided negative-pressure suction. Data, including operation time, volume of intraoperative blood loss, volume of intraoperative pus suction, time of postoperative drainage tube indwelling, time to restore normal body temperature, length of postoperative hospital stay, and intraoperative and postoperative complications, were collected. RESULTS: The age of the patients was 59 (53-69) years. Eight, six, two, and two patients had hypertension, type 2 diabetes, rheumatoid arthritis, and renal calculi, respectively. The operations were successful forall11 patients. Eight, two, and one patients required one, two, and three channels, respectively, to clear their abscess. The average operation time was 44 (30-65) min, and intraoperative blood loss was 16 (10-20) ml. The volume of intraoperative pus suction was 280 (200-400) ml, time of postoperative drainage tube indwelling was 8.2 (6-12) days, and time to restoring normal body temperature was 0.8 (0.5-2) days. The average postoperative hospital stay was 9.8 (7-14) days. No severe intraoperative or postoperative complications occurred. The postoperative follow-up time was typically 4.8 (3-8) months, and there were no recurrences. CONCLUSION: Percutaneous nephroscopy combined with ultrasound-guided negative-pressure suction might be a feasible method for treating PA.


Assuntos
Abscesso Abdominal , Diabetes Mellitus Tipo 2 , Cálculos Renais , Infecções Urinárias , Abscesso Abdominal/etiologia , Abscesso/etiologia , Idoso , Perda Sanguínea Cirúrgica , Drenagem/métodos , Humanos , Cálculos Renais/etiologia , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Sucção , Ultrassonografia de Intervenção , Infecções Urinárias/etiologia
3.
Pharmaceuticals (Basel) ; 15(9)2022 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-36145381

RESUMO

Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M-T (1-8). Their gross structures and stereochemistry were elucidated by HR-ESI-MS, 1D and 2D NMR spectra, X-ray diffraction, quantum chemical computation of the ECD spectrum, and the in situ dimolybdenum CD method. The anti-neuroinflammatory activity of the isolated compounds was performed in BV-2 microglia cells. As a result, compound 1 displayed a notable anti-neuroinflammatory effect via suppressing the LPS-induced IκB degradation and restricting the activation of the PI3K/AKT and p38 MAPK pathways.

4.
Cell Rep Med ; 3(9): 100744, 2022 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-36099917

RESUMO

Plasma cell responses are associated with anti-tumor immunity and favorable response to immunotherapy. B cells can amplify anti-tumor immune responses through antibody production; yet B cells in patients and tumor-bearing mice often fail to support this effector function. We identify dysregulated transcriptional program in B cells that disrupts differentiation of naive B cells into anti-tumor plasma cells. The signaling network contributing to this dysfunction is driven by interleukin (IL) 35 stimulation of a STAT3-PAX5 complex that upregulates the transcriptional regulator BCL6 in naive B cells. Transient inhibition of BCL6 in tumor-educated naive B cells is sufficient to reverse the dysfunction in B cell differentiation, stimulating the intra-tumoral accumulation of plasma cells and effector T cells and rendering pancreatic tumors sensitive to anti-programmed cell death protein 1 (PD-1) blockade. Our findings argue that B cell effector dysfunction in cancer can be due to an active systemic suppression program that can be targeted to synergize with T cell-directed immunotherapy.


Assuntos
Neoplasias Pancreáticas , Receptor de Morte Celular Programada 1 , Animais , Interleucinas/metabolismo , Ativação Linfocitária , Camundongos , Neoplasias Pancreáticas/terapia , Plasmócitos , Receptor de Morte Celular Programada 1/genética
5.
Biomed Pharmacother ; 153: 113459, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36076574

RESUMO

Acute respiratory distress syndrome (ARDS) is a lethal clinical entity that has become an emergency event with the outbreak of COVID-19. However, to date, there are no well-proven pharmacotherapies except dexamethasone. This study is aimed to evaluate IRAK4 inhibitors as a potential treatment for ARDS-cytokine release syndrome (CRS). We applied two IRAK4 inhibitors, BAY-1834845 and PF-06650833 to an inhaled lipopolysaccharide (LPS)-induced ARDS mouse model with control of high dose dexamethasone (10 mg/kg). Unexpectedly, although both compounds had excellent IC50 on IRAK4 kinase activity, only BAY-1834845 but not PF-06650833 or high dose dexamethasone could significantly prevent lung injury according to a blinded pathology scoring. Further, only BAY-1834845 and BAY-1834845 combined with dexamethasone could effectively improve the injury score of pre-existed ARDS. Compared with PF-06650833 and high dose dexamethasone, BAY-1834845 remarkably decreased inflammatory cells infiltrating lung tissue and neutrophil count in BALF. BAY-1834845, DEX, and the combination of the two agents could decrease BALF total T cells, monocyte, and macrophages. In further cell type enrichment analysis based on lung tissue RNA-seq, both BAY-1834845 and dexamethasone decreased signatures of inflammatory cells and effector lymphocytes. Interestingly, unlike the dexamethasone group, BAY-1834845 largely preserved the signatures of naïve lymphocytes and stromal cells such as endothelial cells, chondrocytes, and smooth muscle cells. Differential gene enrichment suggested that BAY-1834845 downregulated genes more efficiently than dexamethasone, especially TNF, IL-17, interferon, and Toll-like receptor signaling.


Assuntos
COVID-19 , Síndrome do Desconforto Respiratório , Animais , COVID-19/tratamento farmacológico , Dexametasona/farmacologia , Células Endoteliais , Quinases Associadas a Receptores de Interleucina-1 , Lipopolissacarídeos/farmacologia , Pulmão , Camundongos , Síndrome do Desconforto Respiratório/tratamento farmacológico , Síndrome do Desconforto Respiratório/prevenção & controle
6.
Biomaterials ; 288: 121698, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-36038422

RESUMO

Diabetic ulcers (DUs), a devastating complication of diabetes, are intractable for limited effective interventions in clinic. Based on the clinical samples and bioinformatic analysis, we found lower level of CCN1 in DU individuals. Considering the accelerated proliferation effect in keratinocytes, we propose the therapeutic role of CCN1 supplementation in DU microenvironment. To address the challenge of rapid degradation of CCN1 in protease-rich diabetic healing condition, we fabricated a nanoformulation of CCN1 (CCN1-NP), which protected CCN1 from degradation and significantly raised CCN1 intracellular delivery efficiency to 6.2-fold. The results showed that the intracellular CCN1 exhibited a greater anti-inflammatory and proliferative/migratory activities once the extracellular signal of CCN1 was blocked in vitro. The nanoformulation unveils a new mechanism that CCN1 delivered into cells interacted with Eukaryotic translation initiation factor 3 subunit A (EIF3A) to downregulate autophagy-related 7 (ATG7). Furthermore, topical application of CCN1-NP had profound curative effects on delayed wound healing in diabetes both in vitro and in vivo. Our results illustrate a novel mechanism of intracellular EIF3A/CCN1/ATG7 axis triggered by nanoformulation and the therapeutic potential of CCN1-NP for DU management.


Assuntos
Proteína Rica em Cisteína 61 , Diabetes Mellitus , Sistemas de Liberação de Fármacos por Nanopartículas , Proteína 7 Relacionada à Autofagia/metabolismo , Proteína Rica em Cisteína 61/metabolismo , Proteína Rica em Cisteína 61/farmacologia , Diabetes Mellitus/metabolismo , Fator de Iniciação 3 em Eucariotos/metabolismo , Humanos , Queratinócitos/metabolismo , Sistemas de Liberação de Fármacos por Nanopartículas/farmacologia , Nanopartículas , Cicatrização/fisiologia
7.
Chemosphere ; 308(Pt 1): 136172, 2022 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-36037949

RESUMO

Coupled solid carbon source biofilm carriers (CCBs) was usually utilized to enhance the treatment efficiency of low carbon/nitrogen (C/N) wastewater. However, current CCBs have low carbon release capacity because of its small inner mass transfer coefficient. Therefore, this study innovatively applied pore-forming methods to modify CCBs. After orthogonal selections, two porous CCBs, which were respectively prepared through circulating freezing pore-forming method (CCB2) and ammonium bicarbonate pore-forming method (CCB3), were proposed and further applied in sequencing batch moving bed biofilm reactors (SBMBBRs). The results indicated that circulating freezing pore-forming method could improve the mechanical strength and carbon source release rate of CCBs. In addition, CCB2 could significantly enhance the total nitrogen (TN) removal efficiency of SBMBBRs, when compared with the non-porous CCBs (i.e., CCB1). Further biofilm and simultaneous nitrification and denitrification (SND) rate calculation attributed this enhancement to the higher biofilm amount (i.e., 0.06 g g-1 CCB) and the higher SND rate (i.e., 33.60%). Microbial community analysis reiterated these observations that CCB2 and CCB3 could accumulate Proteobacteria, Actinobacteriota and Nitrospirota, and also stimulate nitrification and denitrification associated pathways. More importantly, the cost calculation indicated CCB2 cost only 47.37% of CCB1 and 31.34% of CCB3, showing highly economic applicability. Overall, our results collectively proved that CCBs manufactured by circulating freezing pore-forming method could provide more carbon releasing points and microorganisms attaching positions, exhibiting effectively nitrogen removal when treating low C/N wastewater.

8.
Bioorg Chem ; 128: 106068, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35933896

RESUMO

Vernonia amygdalina Delile is generally used as green vegetables for cuisine in Nigeria and health tea or products in southeast of china. It was also used as folk medicine for the treatment of anti-helminth, febrifuge, digestive tonic and wounds. In this study, eleven undescribed phytosterols (1-2, 4-12) and six known analogues (3, 13-17) were isolated from the stems of V. amygdalina. Their structures including absolute configurations were elucidated by comprehensive spectroscopic methods (1D and 2D NMR, HRESIMS), X-ray diffraction and comparison of their ECD spectra. Besides, the tautomerism of phytosterols (1, 3-6, 12-17) with hemiacetal moiety were analyzed by solution NMR with different deuterated solvent and variable-temperature experiments. In addition, the cytotoxic activities of isolates against HeLa cells were evaluated. As a result, compound 10 exhibited the most potent anti-cervical cancer activity with the IC50 of 22.44 µM. Mechanism studies indicated that 10 triggered HeLa cells apoptosis through activating caspase signaling pathway. Furthermore, 10 could arrest the cell cycle in S phase and suppress the activation of the PI3K/AKT/mTOR pathway, leading to the inhibition of HeLa cells proliferation.


Assuntos
Neoplasias , Fitosteróis , Vernonia , Células HeLa , Humanos , Fosfatidilinositol 3-Quinases , Extratos Vegetais/química , Vernonia/química
9.
Comput Math Methods Med ; 2022: 6808648, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35991150

RESUMO

Objective: To study the application value of PBL (Problem-Based Learning) combined with a situational simulation teaching method in clinical practice teaching of radiology. Methods: 120 interns who practiced in the radiology department of our hospital from 2020 to 2021 were randomly divided into a study group and a control group. The research group used PBL combined with the scenario simulation teaching method to carry out clinical practice teaching activities. The control group was carried out according to the conventional teaching plan. After 3 months, the teaching effect and satisfaction of the two groups were compared. Results: The imaging report quality control score, intravenous contrast agent score, and practice test score in the study group were higher than those in the control group. The scores of the small class and special class in the research group were higher than those in the control group, and the difference was statistically significant (P < 0.05). The scores of job competency questionnaire in the research group were higher than those in the control group (P < 0.05). The occupational self-efficacy questionnaire score of the research group was higher than that of the control group (P < 0.05). The nursing practice satisfaction score of the research group was higher than that of the control group (P < 0.05). Conclusion: The value of PBL combined with the scenario simulation teaching method in the teaching of radiology clinical practice is significant, which can improve the work ability of interns and make them more satisfied.


Assuntos
Aprendizagem Baseada em Problemas , Radiologia , Humanos , Aprendizagem Baseada em Problemas/métodos , Inquéritos e Questionários
10.
Mol Psychiatry ; 2022 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-36028572

RESUMO

The excitatory neurotransmitter glutamate shapes learning and memory, but the underlying epigenetic mechanism of glutamate regulation in neuron remains poorly understood. Here, we showed that lysine demethylase KDM6B was expressed in excitatory neurons and declined in hippocampus with age. Conditional knockout of KDM6B in excitatory neurons reduced spine density, synaptic vesicle number and synaptic activity, and impaired learning and memory without obvious effect on brain morphology in mice. Mechanistically, KDM6B upregulated vesicular glutamate transporter 1 and 2 (VGLUT1/2) in neurons through demethylating H3K27me3 at their promoters. Tau interacted and recruited KDM6B to the promoters of Slc17a7 and Slc17a6, leading to a decrease in local H3K27me3 levels and induction of VGLUT1/2 expression in neurons, which could be prevented by loss of Tau. Ectopic expression of KDM6B, VGLUT1, or VGLUT2 restored spine density and synaptic activity in KDM6B-deficient cortical neurons. Collectively, these findings unravel a fundamental mechanism underlying epigenetic regulation of synaptic plasticity and cognition.

11.
J Inflamm Res ; 15: 4637-4647, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35996685

RESUMO

Background: Psoriasis is an immune-mediated chronic systemic inflammatory skin disease whose diagnosis and severity assessment pose challenges for clinicians worldwide. The use of serum biomarkers facilitates the early diagnosis and treatment of psoriasis. Methods: This case-control study compared tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-17, IL-10, and fibrinogen-like protein 1 (FGL1) levels of 139 untreated psoriasis patients and 140 healthy controls. Serum samples were collected, and enzyme-linked immunosorbent assays were performed to quantify their levels. Subgroups were analyzed according to abnormal lipid metabolism status. Results: Compared to controls, patients with psoriasis exhibited lower concentrations of serum TNF-α, IL-17, and FGL1 (P < 0.05). A correlation analysis showed that FGL1 was inversely correlated with high-density lipoprotein cholesterol and IL-17 in the psoriatic state. Stepwise multiple regression analysis revealed that FGL1 and total cholesterol were the independent determinants of Psoriasis Area and Severity Index (PASI) score in psoriasis patients. The area under the receiver operating characteristic curve of FGL1 assessing moderate-to-severe psoriasis and mild psoriasis was 0.70, while the area under the curve (AUC) assessing severe psoriasis and mild-to-moderate psoriasis was 0.67, better than that of IL-17. In addition, FGL1, but not IL-17, was able to identify psoriasis with abnormal lipid metabolism to a certain extent (AUC = 0.60). Conclusion: In conclusion, serum FGL1 may be a promising biomarker for diagnosing and staging psoriasis. It may also be involved in its progression and comorbid abnormal lipid metabolism.

13.
Small ; : e2203281, 2022 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-35989101

RESUMO

Owing to their rich surface chemistry, high conductivity, tunable bandgap, and thermal stability, structured 2D transition-metal carbides, nitrides, and carbonitrides (MXenes) with modulated atomic environments have emerged as efficient electrochemical energy conversion systems in the past decade. Herein, the most recent advances in the engineering of tunable structured MXenes as a powerful new platform for electrocatalytic energy conversion are comprehensively summarized. First, the state-of-the-art synthetic and processing methods, tunable nanostructures, electronic properties, and modulation principles of engineering MXene-derived nanoarchitectures are focused on. The current breakthroughs in the design of catalytic centers, atomic environments, and the corresponding structure-performance correlations, including termination engineering, heteroatom doping, defect engineering, heterojunctions, and alloying, are discussed. Furthermore, representative electrocatalytic applications of structured MXenes in energy conversion systems are also summarized. Finally, the challenges in and prospects for constructing MXene-based electrocatalytic materials are also discussed. This review provides a leading-edge understanding of the engineering of various MXene-based electrocatalysts and offers theoretical and experimental guidance for prospective studies, thereby promoting the practical applications of tunable structured MXenes in electrocatalytic energy conversion systems.

14.
ACS Appl Mater Interfaces ; 14(33): 37478-37492, 2022 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-35951372

RESUMO

Astrocytes, as the most plentiful subtypes of glial cells, play an essential biphasic function in ischemic stroke (IS). However, although having beneficial effects on stroke via promoting nerve restoration and limiting lesion extension, astrocytes can unavoidably cause exacerbated brain damage due to their participation in the inflammatory response. Therefore, seeking an effective and safe drug/strategy for protecting and regulating astrocytes in stroke is urgent. Here, we employ tetrahedral framework nucleic acid (tFNA) nanomaterials for astrocytes in stroke, considering their excellent biological properties and outstanding biosafety. In vitro, tFNA can inhibit calcium overload and ROS regeneration triggered by oxygen-glucose deprivation/reoxygenation (OGD/R), which provides a protective effect against astrocytic apoptosis. Furthermore, morphological changes such as hyperplasia and hypertrophy of reactive astrocytes are restrained, and the astrocytic polarization from the proinflammatory A1 phenotype to the neuroprotective A2 phenotype is facilitated by tFNA, which further alleviates cerebral infarct volume and facilitates the recovery of neurological function in transient middle cerebral artery occlusion (tMCAo) rat models. Moreover, the TLRs/NF-κB signaling pathway is downregulated by tFNA, which may be the potential mechanism of tFNA for protecting astrocytes in stroke. Collectively, we demonstrate that tFNA can effectively mediate astrocytic apoptosis, activation, and polarization to alleviate brain injury, which represents a potential intervention strategy for IS.


Assuntos
Isquemia Encefálica , AVC Isquêmico , Ácidos Nucleicos , Acidente Vascular Cerebral , Animais , Apoptose , Astrócitos/metabolismo , Isquemia Encefálica/tratamento farmacológico , Isquemia Encefálica/metabolismo , Ácidos Nucleicos/metabolismo , Ácidos Nucleicos/farmacologia , Ratos , Acidente Vascular Cerebral/tratamento farmacológico
15.
Bioorg Chem ; 128: 106088, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36007479

RESUMO

Four undescribed seco-polyprenylated acylphloroglucinols (seco-PAPs), elodeoidesones A-D (1-4), were characterized from Hypericum elodeoides. Compound 1 represents the 1,6-seco-PAPs with fascinating 5/5 fused ring, while 2-4 possess a 1,2-seco-PAPs skeleton with a five-membered lactone core. Their structures including absolute configurations were established by spectroscopic analyses and quantum chemical computations. A possible biosynthetic pathway of 1-4 from normal PAPs was proposed. All the isolates were investigated for their cytotoxicity against tumor cells. Notably, 1 inhibited the proliferation of MCF-7 cells with the IC50 value of 7.34 µM. Mechanism investigation indicated that 1 induced MCF-7 cells apoptosis by blocking cell cycle at S phase via inducing oxidative DNA damage.


Assuntos
Hypericum , Apoptose , Pontos de Checagem do Ciclo Celular , Humanos , Hypericum/química , Células MCF-7 , Estrutura Molecular , Estresse Oxidativo , Floroglucinol/química
16.
Front Public Health ; 10: 967311, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36033811

RESUMO

Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and individualized treatment have been challenged since its approval. With the in-depth clinical research of linezolid, we have changed our attitude toward its therapeutic drug monitoring and our view of individualized treatment. On the basis of summarizing the existing clinical studies, and based on the practical experience of each expert in their respective professional fields, we have formed this expert consensus. Our team of specialists is a multidisciplinary team that includes pharmacotherapists, clinical pharmacology specialists, critical care medicine specialists, respiratory specialists, infectious disease specialists, emergency medicine specialists and more. We are committed to the safe and effective use of linezolid in patients in need, and the promotion of its therapeutic drug monitoring.


Assuntos
Monitoramento de Medicamentos , Oxazolidinonas , Antibacterianos , Humanos , Linezolida
17.
Comput Intell Neurosci ; 2022: 3448182, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36035839

RESUMO

Objective: A case-control study explored the application of case-based teaching methods in the clinical teaching of radiology. Materials and Methods: 126 radiology interns of grade 2018 were selected by cluster sampling and randomly divided into the research group and the control group. The traditional teaching approach was used in the control group and the primary teaching principle was used in the research group. The teaching effects of the two groups were compared. Results: The interns' test scores, the research group's case summary multiple-choice questions, case-group multiple-choice questions, case analysis questions, theoretical total scores, and practical operation assessment scores were significantly higher than those of the control group, and the difference was statistically significant (P < 0.05). The total score of dimensions of the interns' critical thinking ability in the study group were significantly higher than those in the control group, and the difference was statistically significant (P < 0.05). The interns' perception of teachers, students' academic self-perception, students' perception of environment, students' social self-perception, and the total score of the DREEM scale in the study group were considerably greater than those in the control group, and the difference was statistically significant (P < 0.05). After teaching, the scores of systematic thinking ability and evidence-based thinking ability of the interns were significantly increased. The improvement in the study group was more significant than that in the control group, and the difference was statistically significant (P < 0.05). Following teaching, the scores of learning interest, self-management, plan implementation, and mutual cooperation of the interns in the two groups were significantly upregulated, and the difference was statistically significant (P < 0.05). Among them, the improvement of interns' abilities in the research group was significantly better than that in the control group, and the difference was statistically significant (P < 0.05). The scores of learning goal, learning process, learning effect, classroom environment construction, teaching strategy, and technology application in the research group were greater than those in the control group, and the difference was statistically significant (P < 0.05). The satisfaction rate of the study group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion: The application of the case teaching method based on primary teaching principle in the radiology clinical teaching course is helpful to cultivate students' critical thinking ability and improve students' performance and classroom teaching effectiveness.


Assuntos
Radiologia , Estudos de Casos e Controles , Humanos , Aprendizagem , Estudantes , Ensino
18.
ACS Omega ; 7(25): 21701-21713, 2022 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-35785317

RESUMO

This paper mainly studies the structure and performance of a smart knitting sensor and selects three kinds, 1 + 1, 2 + 2, and 2 + 1, of fake rib stitches. 70D and 100D silver-plated conductive yarns with a 40D carbon black conductive yarn are knitted into different fabrics in the way of plating. Finally, the related properties of the conductive fabrics of different sizes are studied. This study found that the prepared knitted fabrics can not only meet the requirements of air permeability standards in both the plain needle area and the plated area greatly but also have good elastic recovery. When the number of the plated conductive yarn is the same, the conductivity of the fabric increases with the increase in the conductive yarn wale number, and the smaller the number of plated yarns, the greater the influence of the wale number on the change in conductivity. When the number of plated yarn wales is the same, the conductivity of the fabric decreases with the increase in the conductive yarn course number, and the smaller the wale number, the smaller the effect of the course number on the change in conductivity. When the fabric formed by a silver-plated conductive yarn is in a stretched state, the conductivity decreases. However, the electrical conductivity of the 100D silver-plated fabric is more stable than that of the 70D silver-plated fabric. The conductivity of the carbon black conductive fabric is in the order of MΩ, and the conductivity of the conductive fabric changes greatly and disperses when the conductive fabric is in a stretched state. The conductive stability of the 1 + 1 fake rib stitch samples was the best before washing. On the contrary, the conductive stability of the 2 + 2 fake rib stitch fabrics was relatively good after washing.

19.
BMC Neurol ; 22(1): 244, 2022 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-35787797

RESUMO

BACKGROUND: An anterior inferior cerebellar artery (AICA) that crosses the right trigeminal nerve is an uncommon arterial anatomic variation. In this anatomical position, it is difficult to separate or move the offending blood vessels and nerves. We report an uncommon case of trigeminal neuralgia (TN) caused by compression of the trigeminal ganglion by a branch of the AICA. CASE PRESENTATION: A 34-year-old man with 5 years history who complained of pain on the right side of the face (area V1). The symptoms gradually worsened, and the pain episodes became intense and frequent. Magnetic resonance imaging (MRI) of the cerebrum showed a small blood vessel passing through the right trigeminal nerve. Microvascular decompression (MVD) was performed,because medication was ineffective. Intraoperative exploration confirmed that the vessel which was a branch of the AICA passing through the right trigeminal nerve. As while the artery was temporarily clipped, electrophysiological monitoring showed a decrease in the amplitude of nerve activity. As the artery was considered too important to be sacrificed, the space between the nerves was enlarged mildly, the artery was liberated, the Teflon implant was shredded and placed between the artery branches and nerve to make the blood vessels as perpendicular as possible to the nerve. The patient had no neurological dysfunction and no pain after 8 months of follow-up. CONCLUSION: MVD is an effective treatment for artery-induced trigeminal nerve compression, but we report a novel procedure that avoids the complication of facial numbness caused by cutting the offending vessels and incision of the trigeminal nerve.


Assuntos
Cirurgia de Descompressão Microvascular , Neuralgia do Trigêmeo , Adulto , Artéria Basilar/cirurgia , Humanos , Masculino , Cirurgia de Descompressão Microvascular/métodos , Dor/complicações , Nervo Trigêmeo/diagnóstico por imagem , Nervo Trigêmeo/cirurgia , Neuralgia do Trigêmeo/diagnóstico por imagem , Neuralgia do Trigêmeo/etiologia , Neuralgia do Trigêmeo/cirurgia
20.
J Colloid Interface Sci ; 626: 1051-1061, 2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-35868195

RESUMO

Anisotropic silver nanoplates are widely anticipated in multifunctional textiles, but their large-scale promotion is limited by the shortcomings of long reaction time, uncontrollable shape and low yield in the preparation process. In this study, a microwave-assisted strategy is provided to prepare shape-controllable silver nanoplates for coloration of non-woven fabric. Anisotropic Ag nanoplates are efficiently coated on the surface of chitosan-pretreated fabric by a simple solution impregnation method, which generates the fabric with tunable color and multiple functions. The Ag nanoplates loaded fabric exhibits excellent photothermal properties at 808 nm laser irradiation due to its unique plasmonic absorption features. Colored fabric shows a strong synergistic antibacterial effect, including silver ion release and hyperthermia caused by the photothermal effect under near-infrared (NIR) light. Additionally, colored fabrics can be used as colorimetric sensors for selective detection of H2S. The colorimetric values of visible color signal of fabric-based H2S gas sensor can be real-time precisely detected using a smartphone, enlightening its high potential as a wearable toxic gas alarm device for the simple and rapid detection of hazardous gases.


Assuntos
Sulfeto de Hidrogênio , Nanopartículas Metálicas , Antibacterianos/farmacologia , Colorimetria/métodos , Gases , Prata/farmacologia , Têxteis
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