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1.
J Ethnopharmacol ; 246: 112210, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31479707

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Compound Danshen tablet, an herbal preparation consisting of salviae miltiorrhizae, notoginseng and borneolum, is extensively employed clinically to treat angina pectoris, coronary arteriosclerosis and significantly improve microcirculation. AIM OF THE STUDY: To reveal the potential underlying cardioprotective mechanism(s) in isoproterenol-induced myocardial injury in high-fat-diet fed mice. MATERIALS AND METHODS: Cardiac transcriptomics was analyzed by Illumina mRNA-Seq sequencing. The restored cardiovascular diseases (CVD)-related genes by Compound Danshen tablet were validated by quantitative real time polymerase chain reaction (qRT-PCR). Furthermore, Cardiac metabolomics were also performed using gas chromatography-mass spectrometry. RESULTS: From the transcriptomics study, we found the levels of 24 up-regulated and 44 down-regulated genes in the control compared to model groups. Among them, seven gene levels were restored by treatment of Compound Danshen tablet. Four CVD-related genes at the mRNA level (Sprr1a, Ppp1r3c, Bmp10 and Hspa1b) were validated successfully by qRT-PCR. From the metabolomics study, 37 differentially expressed metabolites were identified between the control and model groups. Among them, 21 metabolites were restored by treatment of Compound Danshen tablet. These altered metabolites are involved in glucose metabolism, fatty acid metabolism and amino acid metabolism. CONCLUSION: These genes and metabolites might provide clues for further molecular mechanistic study of Compound Danshen tablet.

2.
Ecotoxicol Environ Saf ; 187: 109829, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31654869

RESUMO

Screening appropriate washing agents to remediate soils contaminated with heavy metals is crucial for decreasing metal hazards posing to environment and human health. In this study, two plant washing agents-water-extracted from Fagopyrum esculentum and Fordiophyton faberi, were applied to remove soil Pb, Zn, and Cd by washing. Results indicated that metal removals augmented with increase of washing solution concentrations, decreased with increasing pH values of the solution and followed the pseudo-second-order model depending on contact duration. At concentration of 50 g/L, pH 3 and contact duration of 120 min, F. esculentum had higher removals of Pb (5.98-6.83%), Zn (21.82-27.94%), and Cd (39.90-40.74%) than those of F. faberi. And metal ions could be removed by binding with carboxyl, hydroxyl, amide, amine and aromatic groups in washing solutions. The potential risks of residual metals declined by 51.35-52.12% for mine soil and 48.51-49.96% for farmland soil with exchangeable and carbonate-bound fractions obviously extracted after a single washing (P < 0.05). And soil organic carbon and nutrients increased to some extent except for total phosphorus and available potassium. Moreover, soil phytotoxicity lowered except that some adverse effects on seed germination existed. Therefore, the water extract from F. esculentum is a promising washing agent for heavy metal removal.

3.
Bioresour Technol ; 295: 122255, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31639626

RESUMO

To investigate the feasibility of vegetal gallic acid (GA) improving silage quality, fermentation parameter, nitrogen distribution and bacterial community of mulberry leaves and stylo ensiled with 1% and 2% GA were analyzed after 60-d fermentation. The results showed that GA addition decreased dry matter loss (6.08% vs 5.35%, 17.79% vs 11.56% in mulberry leaves and style silage, respectively), pH (6.51 vs 5.98, 5.55 vs 4.57), butyric acid (0.41% and 0.83% DM, undetected in GA groups) and ammonia-N (0.71% vs 0.19%, 1.46% vs 0.29% TN) contents and increased lactic acid (2.27% vs 6.68%, 0.91% vs 1.91% DM) and acetic acid (1.68% vs 3.20%, 0.97% vs 2.02% DM) contents. Meanwhile, the relative abundance of Clostridium or Enterobacter was decreased, and that of lactate-producing bacteria was increased in mulberry leaves and stylo silage. In conclusion, GA could be used as a green additive to improve fermentation quality and protein preservation during ensiling.


Assuntos
Morus , Silagem , Bactérias , Fermentação , Ácido Gálico , Nitrogênio , Folhas de Planta
4.
Bioresour Technol ; 295: 122268, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31675519

RESUMO

To find a comprehensive way to enhance the utilizability of steam-exploded hippophae, calcium oxide (CaO) preimpregnation, cellulase-added storage and saccharification with addition of Tween 20 were investigated in this study. Both CaO preimpregnation and cellulase addition promoted the ensiling fermentation of anaerobically stored steam-exploded hippophae indicated by lower cellulose proportion and higher organic acids content, but led to the decrease of saccharification yield by 11.83% and 46.77-51.22%, respectively. When taking into account of organic acids being utilizable energy source, storing with addition of cellulase enhanced the utilizability of the materials in whole. Moreover, the addition of Tween 20 enhanced saccharification yield of the steam-exploded hippophae by 26.69-45.25%. Additionally, FTIR and XRD spectra clearly illustrated the structural alteration during storage. It is concluded that storing with addition of cellulase and hydrolyzing with addition of Tween 20 can enhance the utilizability of steam-exploded hippophae.


Assuntos
Celulase , Hippophae , Compostos de Cálcio , Hidrólise , Óxidos , Polissorbatos , Vapor
5.
J Nanosci Nanotechnol ; 20(3): 1859-1865, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31492353

RESUMO

As oxidation is inevitable during application of microwave absorbing materials (MAM) exposed to oxygen-containing atmosphere at elevated temperatures. The investigations concerning influences of oxidation on microstructure and microwave absorption (MA) properties are of great significance. Aiming to better regulating MA for Si3N4-based ceramics serviced in high temperature environment, the evolution of MA properties of SiCw/Si3N4 composites (SwSN) after oxidation at 1200 °C in ambient air for short time was studied. It was found that after oxidation for 7.5 h, both the real and imaginary permittivity of SwSN showed only slight decrease due to good oxidation protection provided by dense SiO2 layer formed on the surface. Moreover, SwSN after short-time of oxidation also showed an almost negligible decline in MA properties. SwSN which has good oxidation resistance and stable microwave attenuation abilities was subjected to oxidation at 1200 °C for short time. The results showed its favorable and potential applications in high-temperature microwave absorption fields.

6.
J Nanosci Nanotechnol ; 20(3): 1962-1967, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31492368

RESUMO

Oroxylum as a traditional Chinese medicine, was used as a green and novel bio-template to synthesize tremella-like Li3V2(PO4)3/C composite (LVPC) cathode materials by adopting a facile immersion method. The microstructures were analyzed by X-ray diffraction analysis, scanning electron microscopy, and transmission electron microscopy. The electrochemical properties were investigated by galvanostatic charge-discharge experiments. The LVPC revealed specific capacity of 95 mAh·g-1 at 1 C rate within potential range of 3.0-4.3 V. After 100 cycles at 0.2 C, the retention of discharge capacity was 96%. The modified electrochemical performance is mainly resulted from the distinct tremella-like structure.

7.
Food Chem ; 303: 125401, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31466031

RESUMO

Salt addition and thermal pretreatment were used to improve the freeze-thaw stability of Pickering emulsion gels (PEGs) stabilized by compound proteins. Thermal pretreatment with the presence of salt could promote the formation of gel-like structure and alter the interactions between the emulsion droplets of PEGs, sequentially increase the resistance of the PEGs to water separation, creaming, and oiling-off during freeze-thaw cycles (freeze at -20 °C for 22 h and thawing at 37 °C for 2 h), especially at higher salt levels (200 and 500 mM). Microstructures indicated that the presence of high salt concentration and heat pretreatment could help to maintain the gel-like structures of PEGs during freeze-thaw cycles. Overall, our results showed that novel viscoelastic food materials with good freeze-thaw stability can be produced by controlling the electrostatic interactions between the emulsion droplets and the gelation of emulsion gels. These materials may be useful for application in frozen food products.


Assuntos
Fixadores/química , Géis/química , Emulsões/química , Congelamento , Temperatura Alta , Óleos/química , Concentração Osmolar , Cloreto de Sódio/análise , Água/química
8.
Anal Chim Acta ; 1094: 160-167, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31761043

RESUMO

Metal-organic cages (MOCs) are a novel kind of porous materials which have three dimensional structures with perpetual and well-defined holes. They have attracted wide consideration for relatively simple synthesis and potential applications such as separation, sensing, microreactor and catalysis etc. In this study, a homochiral MOC [Zn3L2] was prepared as a novel stereoselective stationary phase and added into poly (ionic liquid-co-ethylene dimethacrylate) (Zn3L2@poly(IL-co-EDMA)) monolith for capillary electrochromatography (CEC). The chiral analytes comprising mandelic acid, benzoin and furoin enantiomer were separated perfectly using the monolithic column Zn3L2@poly(IL-co-EDMA), and the effects of buffer pH, acetonitrile percentage and buffer concentration on enantiomers separation were confirmed. Moreover, incorporation of MOC [Zn3L2] into IL polymer monolith strengthened obviously the stereoselective isolation of some positional isomers (such as nitrophenols, nitrotoluenes, xylenes, and ionones). The relative standard deviations (RSDs) of the retention time for intra-day (n = 5) and inter-day (n = 3) and column-to-column (n = 3) enantioseparations were all below 5.0%. This novel monolithic column combined distinct features of the stereoselective materials with the eminent traits of ionic liquid matrix, it has great application potential in CEC.

9.
Opt Express ; 27(21): 30763-30772, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31684319

RESUMO

All-InSb film-based and spiral antenna-assisted Au-InSb-Au metal-semiconductor-metal detector is reported with dual-band photoresponse in the infrared (IR) and millimeter wave range. At IR, the detector exhibits a long wavelength 100% cut-off at 7.3 µm. Under an applied bias of 5 mA, the uncooled blackbody responsivity and specific detectivity are 3.5 A/W and 1×108 Jones, respectively. The f-3dB value measured at 2.94 µm is 75 KHz, corresponding to a detector rise speed of 4.7 µs. At millimeter wave range, the detector shows a narrowband response determined by the coupling of the antenna. A voltage responsivity of 25 V/W is achieved at 167 GHz (1.796 mm) under an applied bias of 25 mA, and the corresponding noise equivalent power (NEP) is 1.0×10-10 WHz-1/2, which can be improved to 1.8×10-12 WHz-1/2 if normalized to the real active semiconductor area. A f-3dB value of 17.5 KHz, corresponding to a detector rise speed of 20 µs is achieved in this range. A proof of principle for IR-modulated photoresponse for millimeter wave is achieved with a maximum modulation depth of 47.5%. This All-InSb film-based detector and the modulation are promising for future novel optoelectronic devices in IR and millimeter waves.

10.
Aging Ment Health ; : 1-9, 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31718249

RESUMO

Objective: Based on the two-component model of theory of mind, the current study explored the cognitive and emotional theory of mind of the elderly by using false-belief pictures and eye-reading tasks respectively, and examined effects of inhibitory control on elderly adults' cognitive and emotional theory of mind.Method: One-hundred twelve elderly participants were randomly recruited, and the control task, cognitive theory of mind, emotional theory of mind and the Stroop task were used.Results: The results showed the following: (1) Elderly adults' theory of mind decreased compared with that of young people; specifically, cognitive theory of mind showed an aging trend (aged above 75 years), while emotional theory of mind developed at a relatively gentle speed during old age; (2) Compared with young people, the inhibitory control of the elderly gently declined among those aged above 75 years; (3) Inhibitory control partially mediated the relationship between age and cognitive theory of mind.Conclusion: The cognitive and emotional components of theory of mind in the elderly were distinct. It was difficult for the elderly to complete psychological tasks related to social cognition that required high inhibitory control; however, they could complete psychological tasks that did not require high inhibitory control.

11.
J Chromatogr Sci ; 2019 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-31711232

RESUMO

Glaucocalyxin A, a novel potent negative Akt regulator, is a major active constituent of Rabdosia japonica. A simple, specific and sensitive ultra-high pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the quantification of glaucocalyxin A in rat plasma, lung and brain tissues after intravenous administration. Sample preparation was carried out through a simple liqiud-liquid extraction with ethyl acetate using bullatine A as internal standard. The chromatographic separation was achieved by using an Agilent ZORBAX Eclipse Plus C18 column (3.0 mm × 100 mm, 1.8 µm) with a mobile phase of acetonitrile and water containing 0.1% formic acid in a gradient elution. Mass spectrometry analysis was conducted in positive ionization mode with multiple reaction monitoring transitions at m/z 333.2 â†’ 157.1 for glaucocalyxin A and m/z 344.2 â†’ 128.1 for IS. Calibration curves were linear over the ranges of 20.0-4000 ng/mL for both plasma and tissue samples (r2 > 0.99). The Lower limit of quantification (LLOQ) was 0.284 ng/mL. The intra-day and inter-day precision relative standard deviation (RSD%) were <14.9%, while the accuracy ranged from -12.5 to 17.0% for LLOQ and quality control samples. This UHPLC-MS/MS method was successfully applied in the pharmacokinetics, lung and brain tissue distributions of glaucocalyxin A after intravenous administration.

12.
Adv Mater ; : e1905025, 2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31713899

RESUMO

Developing efficient and low-cost electrocatalysts for the oxygen evolution reaction (OER) is of paramount importance to many chemical and energy transformation technologies. The diversity and flexibility of metal oxides offer numerous degrees of freedom for enhancing catalytic activity by tailoring their physicochemical properties, but the active site of current metal oxides for OER is still limited to either metal ions or lattice oxygen. Here, a new complex oxide with unique hexagonal structure consisting of one honeycomb-like network, Ba4 Sr4 (Co0.8 Fe0.2 )4 O15 (hex-BSCF), is reported, demonstrating ultrahigh OER activity because both the tetrahedral Co ions and the octahedral oxygen ions on the surface are active, as confirmed by combined X-ray absorption spectroscopy analysis and theoretical calculations. The bulk hex-BSCF material synthesized by the facile and scalable sol-gel method achieves 10 mA cm-2 at a low overpotential of only 340 mV (and small Tafel slope of 47 mV dec-1 ) in 0.1 m KOH, surpassing most metal oxides ever reported for OER, while maintaining excellent durability. This study opens up a new avenue to dramatically enhancing catalytic activity of metal oxides for other applications through rational design of structures with multiple active sites.

13.
Acta Pharmacol Sin ; 2019 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-31685977

RESUMO

At present, few available drugs can be used to either improve pathological features or prevent the progression of Alzheimer's disease (AD). DL0410 ((1,1'-([1,1'-biphenyl]-4,4'-diyl) bis (3-(piperidin-1-yl) propan-1-one) dihydrochloride) is a multiple-target small molecule that has been found to reverse cognitive impairment in different animal models of AD. In this study we evaluated the cognition-improving effects of DL0410 in APP/PS1 transgenic mice and explored the underlying mechanisms. APP/PS1 transgenic mice were administered DL0410 (3, 10, 30 mg· kg-1· d-1, ig) for 2 months. We found that DL0410 administration significantly ameliorated cognitive deficits in both the nest-building and Morris water maze tests. In electrophysiological analysis of hippocampal slices, we showed that DL0410 administration significantly enhanced the field EPSP slope and HFS-induced LTP in CA1 area. Furthermore, we revealed that DL0410 administration significantly increased the phosphorylation of AKT and the activity of GSK-3ß in the hippocampus and cortex. Moreover, DL0410 administration dose-dependently increased the expression level of phosphorylated ERK1/2 in the hippocampus and cortex. In addition, DL0410 dose-dependently decreased the neuronal loss by decreasing the production of Aß deposition, inhibited glial overactivation, and the production of inflammatory cytokines such as TNF-α, IL-1ß, and IL-6. We conclude that DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission via activating the AKT/GSK-3ß and MAPK/ERK signaling pathway and reducing neuronal loss. DL0410 may be an effective agent for AD treatment in the future.

14.
Bioresour Technol ; 296: 122336, 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31704603

RESUMO

Bauhinia variegate flower (BVF) was supposed to improve silage fermentation due to its abundant active components. Thus, corn stalk and stylo were ensiled with addition of 0, 5% or 10% BVF, and then ensiling characteristics, protein fraction and bacterial community were analyzed after 60-day fermentation. The contents of butyric acid (2.9 vs not detected, 13.2 vs 3.0 g/kg DM in corn stalk and stylo silage, respectively), ammonia-N (100.2 vs 83.2, 110.8 vs 61.9 g/kg total N) and free amino acid (35.6 vs 16.5, 35.0 vs 16.4 g/kg total N) were decreased in 10% BVF treated silages. The bacterial diversity was increased, where the relative abundance of Enterobacter or Clostridium decreased and that of lactic acid producing bacteria such as Lactobacillus, Weissella or Enterococcus increased. It is suggested that BVF could be used to improve fermentation quality and nutrient preservation of high-moisture corn stalk and stylo silage.

15.
Cell Transplant ; : 963689719887370, 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31722554

RESUMO

Numerous lines of evidence have shown that microRNAs (miRNAs) play a vital role in regulating the progression in many types of cancers, including T cell acute lymphoblastic leukemia (T-ALL). In this study, the potential underlying mechanism and functional role of miR-141-3p in T-ALL cells were determined. We found that the expression level of miR-141-3p was significantly downregulated, while that of tumor necrosis factor receptor-associated factor 5 (TRAF5) was strongly upregulated in tissues from patients with T-ALL compared with healthy controls. Subsequently, upregulation of miR-141-3p significantly repressed T-ALL cell proliferation and promoted cell apoptosis. Conversely, downregulation of miR-141-3p significantly inhibited cell apoptosis and enhanced T-ALL cell proliferation. We also verified that TRAF5 was the direct target of miR-141-3p in T-ALL cells. Additionally, TRAF5 overexpression significantly repressed cell apoptosis and increased T-ALL cell proliferation. In summary, miR-141-3p regulates T-ALL cell progression by directly targeting TRAF5, and may serve as a potential therapeutic target for T-ALL.

16.
Leuk Lymphoma ; : 1-11, 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31724463

RESUMO

The prognostic significance of loss of the Y chromosome (LOY) in patients with t(8;21)(q22;q22) acute myeloid leukemia (AML) remains poorly understood. To investigate this issue, 226 younger adult male patients with t(8;21) AML from 15 Chinese hematology research centers were retrospectively evaluated, among which, 50.4% had LOY. In patients receiving high-dose cytarabine (HiDAC) consolidation therapy, LOY was associated with a significantly higher cumulative incidence of relapse (CIR, HR = 2.18, p = .048), worse relapse-free survival (RFS, HR = 2.39, p = .026), and worse but not significant overall survival (OS, HR = 2.71, p = .166). A multivariate analysis adjusted for age, WBC, KIT mutations, and minimal residual disease showed LOY to be an independent adverse prognostic factor for relapse in patients on HiDAC consolidation therapy. Our results suggest that LOY may be associated with a high relapse risk in t(8;21) AML patients receiving HiDAC therapy during consolidation.

17.
Viral Immunol ; 32(9): 383-392, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31693458

RESUMO

In this study, the immunoadjuvant effects of recombinant porcine interferon alpha (rPoIFNα) on the killed virus vaccine (KV) of porcine reproductive and respiratory syndrome virus (PRRSV) in pigs were investigated. The experimental pigs were divided into six groups, including normal control group, rPoIFNα control group, PRRSV KV control group, KV+40,000 U rPoIFNα immunization group, KV+400,000 U rPoIFNα immunization group, and KV+4,000,000 U rPoIFNα immunization group. The experimental pigs were boosted immunized on the 28th day after the initial immunization, and the heparinized blood and serum samples were collected at different time points of these two immunizations to detect and evaluate the immune responses of pigs after immunization by ELISA assay, neutralization assay, flow cytometry, and so on. The results showed that the proportion of the levels of PRRSV-specific antibodies, neutralizing antibodies, stimulation index, IL-4, IFN-γ, and lymphocytes within the groups immunized with KV+rPoIFNα were significantly higher than that group immunized with KV alone. The humoral and cellular immune responses in pigs were markedly enhanced by rPoIFNα after the coadministration with KV vaccine. Therefore, we tentatively think that rPoIFNα is a potential immune promoter with prospects for future applications in the pig industry.

18.
Artigo em Inglês | MEDLINE | ID: mdl-31689711

RESUMO

PURPOSE: Idiopathic hypogonadotropic hypogonadism (IHH) and CHARGE syndrome are two distinct developmental disorders sharing features of hypogonadism and/or impaired olfaction. CHD7 variants contribute to >60% CHARGE syndrome and ~10% IHH patients. A variety of extended CHARGE-like features are frequently reported in CHARGE patients harboring CHD7 variants. In this study, we aimed to systematically analyze the diagnostic CHARGE features and the extended CHARGE-like features in IHH patients with CHD7 variants. METHODS: Rare sequencing variants (RSVs) in CHD7 were identified through exome sequencing in 177 IHH probands. Detailed phenotyping was performed in the IHH patients harboring CHD7 variants and their available family members. RESULTS: CHD7 RSVs were identified in 10.2% (18/177) of the IHH probands. Two diagnostic CHARGE features, hearing loss and ear deformities, were significantly enriched in patients with CHD7 variants. Furthermore, CHD7 variants were significantly associated with a panel of extended CHARGE-like phenotypes, including mild ocular defects, dyspepsia/gastroesophageal reflux disease and skeletal defects. We also developed a predictive model for prioritizing CHD7 genetic testing in IHH patients. CONCLUSION: CHD7 variants rarely cause isolated IHH. Surveillance of symptoms in CHARGE syndrome-affected organs will facilitate the proper treatment for these patients. Certain clinical features can be useful for prioritizing CHD7 genetic screening.

19.
Artigo em Inglês | MEDLINE | ID: mdl-31698049

RESUMO

OBJECTIVE: This network meta-analysis compared treatment via laparoscopy (LP), hysteroscopy (HP), combined laparoscopy with hysteroscopy (LH), and vaginal repair (VR) for reducing intermittent abnormal uterine bleeding and caesarean scar defect (CSD) diverticulum depth in patients with CSD. DATA SOURCES: Electronic databases (PubMed, EMBASE, CENTRAL, MEDLINE, ClinicalTrials.gov, Chinese Biomedical Literature Database, and China National Knowledge Integrated) were searched for articles published through June 13, 2018. METHODS OF STUDY SELECTION: The search included randomized controlled trials (RCTs) and observational studies of surgical treatment for CSD. Standardized mean difference (SMD) and 95% confidence intervals (CI) were reported. Randomized controlled trials were evaluated by the Cochrane risk-of-bias tool, observational studies by Risk of Bias in Nonrandomized Studies of Intervention (ROBINS-I), and overall evidence quality by grade. Data were analyzed by STATA (version 15.0, StataCorp, College Station, TX, USA) and R software for windows (version 3.5.0, R Core Team, 2018). TABULATION, INTEGRATION, AND RESULTS: Ten studies (n = 858; 4 RCTs and 6 observational studies) were included. Patients who underwent uterine diverticulum resection by LH had a shorter duration of abnormal uterine bleeding than that by HP (SMD = 1.36, 95% CI, 0.37 to 2.36, p = .007) and VR (SMD = 1.58, 95% CI, 0.97 to 2.19, p < .0001). Laparoscopy with hysteroscopy reduced the CSD diverticulum depth more than VR (SMD = 1.57, 95% CI, 0.54 to 2.61, p = .003). There was no significant difference in efficacy among the surgical procedures. CONCLUSION: Laparoscopy with hysteroscopy reduced intermittent abnormal uterine bleeding and scar depth more than the other surgical interventions. Larger clinical trials are warranted to verify this analysis.

20.
Chin Med J (Engl) ; 132(22): 2664-2669, 2019 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-31725457

RESUMO

BACKGROUND: Colorectal cancer (CRC) has become one of the major life-threatening complications in patients with inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD). This study aimed to explore the clinical-pathologic similarities and differences in the IBD-associated CRC (IBD-CRC) between patients in China and Canada. METHODS: Data of 78 patients with IBD-CRC retrospectively retrieved from two representative medical institutions in Beijing (China) and Calgary (Canada) over the same past 13 years, including 25 (22 UC-associated and three CD-associated) from Beijing group and 53 (32 UC-associated and 21 CD-associated) from Calgary group, were compared with regards to their clinical and pathologic characteristics. RESULTS: Several known features of IBD-CRC were seen in both groups, including long duration and large extent of colitis, active inflammation background, multifocal lesions, and advanced tumor-node-metastasis stage. Beijing group showed a significantly higher percentage of UC (88.0% vs. 60.4%, P = 0.018), younger age at diagnosis of CRC (48.6 ±â€Š12.8 years vs. 61.6 ±â€Š14.7 years, P < 0.001), lower ratio of mucinous adenocarcinoma (7.1% vs. 42.4%, P = 0.001) compared with Calgary group. None of the Beijing group had concurrent primary sclerosing cholangitis, while 5.7% of Calgary group did. Surveillance colonoscopy favored the detection rate of precancerous lesions (41.4% vs.17.0%, P = 0.002). CONCLUSIONS: As compared with patients from the Calgary group, the IBD-CRC patients in Beijing group were younger, less CD-associated and had less mucinous features, otherwise they were similar in many common features.

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