[Herbalogical study on Liangmianzhen (Zanthoxyli Radix)].

Liangmianzhen(Zanthoxyli Radix) has long been used as medicine. The current medicinal parts are different from those in the ancient. As recorded in the Chinese Pharmacopeia, the medicinal part is root. However, in ancient works, the medicinal parts include root, stem, leaf, and fruit. In an attempt to find the historical basis that stem is a reasonable medicinal part, the herbalogical study was carried out on this medicinal based on the formal names, synonyms, original plant, medicinal parts, habitat of the medicinal plant, producing area, processing and preparation methods, efficacy, and indications recorded in ancient Chinese materia medica and local gazetteers. The results showed that Liangmianzhen was firstly recorded as a medicinal in Shennong's Classic of Materia Medica with the formal name of "Manjiao". "Manjiao" was adopted from the Han Dynasty to the Qing Dynasty when it was changed to "Rudijinniu", the name originating from the folk in the south of the Five Ridges. Now, the formal name is "Liangmianzhen", which was firstly recorded in Wuxuan County Gazetteer in 1914 and then as a synonym in the Updated Records of Picking Herbs in the South of the Five Ridges. According to the formal names, synonyms, and the descriptions of the original plant, the medicinal plants of Liang-mianzhen have the characteristics of shrub-like young seedlings, vine adult seedlings, corymbiform thyrsus, stems with thorns, amphitropous golden-yellow roots with horn-like branches, and thorns on both sides of the leaves. Thus, "Manjiao", "Rudijinniu", and "Liangmianzhen" were from the same species of Zanthoxylum nitidum(Rutaceae), which was also verified based on the growth environment, habitat, processing and preparation methods, efficacy, and indications. In ancient times, the stem and root were the main medicinal parts and leaves and fruits were also used. However, in the Chinese Pharmacopeia, root is recorded as the only medicinal part, which is obviously inconsistent with the records in the ancient classics. In light of the limited medicinal resources for Liang-mianzhen, other medicinal parts of Z. nitidum is recommended. This study clarified the medicinal parts of Z. nitidum in history. It is recommended that the stem be added to the medicinal parts of Z. nitidum in the next edition of Chinese Pharmacopeia.

Herbalogical study on Liangmianzhen (Zanthoxyli Radix) / 中国中药杂志

Liangmianzhen(Zanthoxyli Radix) has long been used as medicine. The current medicinal parts are different from those in the ancient. As recorded in the Chinese Pharmacopeia, the medicinal part is root. However, in ancient works, the medicinal parts include root, stem, leaf, and fruit. In an attempt to find the historical basis that stem is a reasonable medicinal part, the herbalogical study was carried out on this medicinal based on the formal names, synonyms, original plant, medicinal parts, habitat of the medicinal plant, producing area, processing and preparation methods, efficacy, and indications recorded in ancient Chinese materia medica and local gazetteers. The results showed that Liangmianzhen was firstly recorded as a medicinal in Shennong's Classic of Materia Medica with the formal name of "Manjiao". "Manjiao" was adopted from the Han Dynasty to the Qing Dynasty when it was changed to "Rudijinniu", the name originating from the folk in the south of the Five Ridges. Now, the formal name is "Liangmianzhen", which was firstly recorded in Wuxuan County Gazetteer in 1914 and then as a synonym in the Updated Records of Picking Herbs in the South of the Five Ridges. According to the formal names, synonyms, and the descriptions of the original plant, the medicinal plants of Liang-mianzhen have the characteristics of shrub-like young seedlings, vine adult seedlings, corymbiform thyrsus, stems with thorns, amphitropous golden-yellow roots with horn-like branches, and thorns on both sides of the leaves. Thus, "Manjiao", "Rudijinniu", and "Liangmianzhen" were from the same species of Zanthoxylum nitidum(Rutaceae), which was also verified based on the growth environment, habitat, processing and preparation methods, efficacy, and indications. In ancient times, the stem and root were the main medicinal parts and leaves and fruits were also used. However, in the Chinese Pharmacopeia, root is recorded as the only medicinal part, which is obviously inconsistent with the records in the ancient classics. In light of the limited medicinal resources for Liang-mianzhen, other medicinal parts of Z. nitidum is recommended. This study clarified the medicinal parts of Z. nitidum in history. It is recommended that the stem be added to the medicinal parts of Z. nitidum in the next edition of Chinese Pharmacopeia.

A 15,400-year record of natural and anthropogenic input of mercury (Hg) in a sub-alpine lacustrine sediment succession from the western Nanling Mountains, South China.

A 15400-year mercury (Hg) accumulation history was reconstructed from a lake sediment core collected from Daping Swamp in western Nanling Mountains, South China. Our results show that the natural input of Hg was deeply influenced by varying climatic conditions. Under wet and warm conditions, increased surface soil organic matter induced by improved vegetation conditions favor an increased input of surface soil-bound Hg to the lake, thus leading to higher Hg accumulation rate, and on the other hand, the direct atmospheric wet deposition of Hg into the lake would also be enhanced. In contrast, under relatively cold and dry conditions, it would display an inverse picture. The signal of anthropogenic influence possibly derived from regional Hg pollution likely started at ~ 3400 cal. years BP, roughly corresponding to the early stage of the Shang Dynasty in Chinese history. Four periods of increased anthropogenic Hg inputs appeared in ~ 3358-2170, ~ 2170-1730, ~ 1369-1043, and especially ~ 600-250 cal. years BP, corresponded to the Shang and Zhou, the Qin and Han, the Sui and Tang, and the Ming and Qing dynasties in China, respectively. A clearly weakened anthropogenic input occurred between~1750 and 1400 cal. years BP, coinciding with the Three Kingdoms to the Southern and Northern Dynasties. Our results revealed the history of the natural Hg accumulation since the Last Deglacial period, and the existence of regional atmospheric Hg induced from anthropogenic activity spanning the last ~ 3400 years.

Ancestry informative DIP loci for dissecting genetic structure and ancestry proportions of Qinghai Tibetan and Tibet Tibetan groups.

Tibetans living in the Qing-Tibet plateau show unique genetic features since they are exposed to the high altitude environment. Accordingly, it is necessary for us to analyze genetic components of the Tibetan groups. Here, genetic structure and ancestry proportions of Tibet Tibetan and Qinghai Tibetan groups are dissected by using a previously published ancestral deletion/insertion polymorphisms (DIPs) panel. Genetic distributions of the analyzed DIPs in both Tibetan groups reveal that some DIPs show relatively balanced frequency distributions with the values ranging from 0.4 to 0.6, implying that these DIPs could be used as individual identification loci for forensic applications in both groups. Besides, the cumulative power of discrimination of the panel also reflects that the panel could serve as a valuable tool for forensic individual identifications in Tibet Tibetan and Qinghai Tibetan groups. Population genetic analyses including principal component analysis, DA genetic distances, phylogenetic tree, and genetic structure reveal that two studied Tibetan groups have closer genetic affiliations with East Asian populations. Genetic differentiation analyses of two Han populations, Xinjiang Uyghur and two Tibetan groups reveal that some DIP loci might be informative for differentiating Uyghurs from the other populations.

Origin and Development of Research on Blackish Facial Patch / 中华中医药杂志

Objective: To discuss the research evolution of blackish facial patch. Methods: According the literatures of past dynasties,the research connotations of blackish facial patch in each dynasty were inspected.Results: During the Warring States era,the name,etiology,pathogenesis,diagnosis and treatment of blackish facial patch had preliminary study,only formulae and drugs absence.In Han and Tang Dynasties,it had proposed the alias of "dustycomplexion" and "blackish and withered face" etc,the etiology of phlegm and drink soiled inside of the body,striae and interstitial space suffering wind,the pathogenesis of hepatic and renal yin deficiency,weakness of the spleen and stomach,moist heat,obstruction of collaterals by blood stasis and discordance of blood-qi,the syndrome description of face like suffering dust,or black as lacquer wood or like tree sparrow egg on the color,and the treatments of formulae and drugs,acupuncture and massage etc;all of the contents were superficial.After the Song Dynasty, the study of etiology,pathogenesis and syndrome were deepen and expanded,and it had increased the pathology concepts of blood weak and kidney deficiency,domination of dryness of Yangming,dry and gloomyof the lung and hepatic and cholic fire prosperous,and the therapeutic tools and drugs were more abundant and concrete than ever,but that literatures were still fragmented and not being a system,without monographs.Entering the modern era,just as the Qing Dynasty,had not any breakthrough.Until the liberation,especially since the 80s of the last century,with the rise of cosmetology in traditional Chinese medicine,the research on blackish facial patch both in form and content dark blotches has achieved unprecedented progress.Conclusion: Understanding the origin and development of blackish facial patch,it will play a fundamental role in the future in-depth study.