Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat.

Foraging decisions involve assessing potential risks and prioritizing food sources, which can be challenging when confronted with changing and conflicting circumstances. A crucial aspect of this decision-making process is the ability to actively overcome defensive reactions to threats and focus on achieving specific goals. The ventral pallidum (VP) and basolateral amygdala (BLA) are two brain regions that play key roles in regulating behavior motivated by either rewards or threats. However, it is unclear whether these regions are necessary in decision-making processes involving competing motivational drives during conflict. Our aim was to investigate the requirements of the VP and BLA for foraging choices in conflicts involving overcoming defensive responses. Here, we used a novel foraging task and pharmacological techniques to inactivate either the VP or BLA or to disconnect these brain regions before conducting a conflict test in male rats. Our findings showed that BLA is necessary for making risky choices during conflicts, whereas VP is necessary for invigorating the drive to obtain food, regardless of the presence of conflict. Importantly, our research revealed that the connection between VP and BLA is critical in controlling risky food-seeking choices during conflict situations. This study provides a new perspective on the collaborative function of VP and BLA in driving behavior, aimed at achieving goals in the face of dangers.

Effect of transcranialdirect current stimulation on the right brain temporal area on processing approach and avoidance attitudes with negation.

Language describes approach/avoidance intentionality by means of attitudinal verbs (e.g., accept vs. reject). The right superior temporal sulcus (rSTS) has been shown to be recruited in processing action goals and approach intentionality in social contexts. In this study, we examine whether transcranial direct current stimulation (tDCS) of this area improves the processing of attitudinal verbs (either of approach or avoidance) in the context of affirmative and negative sentences [e.g., Julio (did not)/included meat on the grocery list]. After being subjected to tDCS, 46 participants were given sentences for passive reading. Sentences were displayed in segments with a fixed time of exposition, and a verb, either the one mentioned in the sentence or an alternative one was displayed 1,500 ms after the sentence (e.g., included vs. excluded, in the example). Participants were told to read them and then press the space bar to continue the experiment. Results showed shorter latencies for approach verbs that were either mentioned in approach sentences or the alternatives in avoidance sentences, both in affirmative and negative versions under anodal conditions compared to sham conditions. Thus, the anodal stimulation of rSTS affected the accessibility of approach verbs that were not modulated either by being mentioned or by sentence polarity. In addition, mentioned verbs had shorter reading times than the alternative ones in negative sentences in the anodal vs. sham condition. This suggests that stimulation caused an effect of negation in the activation of the mentioned verb. Implications are discussed in the context of the role of the rSTS in processing attitudinal verbs and negation to understand better approach and avoidance mediated by language in the framework of the two-step model of negation processing.

Conflict Test Battery for Studying the Act of Facing Threats in Pursuit of Rewards.

Survival depends on the ability of animals to avoid threats and approach rewards. Traditionally, these two opposing motivational systems have been studied separately. In nature, however, they regularly compete for the control of behavior. When threat- and reward-eliciting stimuli (learned or unlearned) occur simultaneously, a motivational conflict emerges that challenges individuals to weigh available options and execute a single behavioral response (avoid or approach). Most previous animal models using approach/avoidance conflicts have often focused on the ability to avoid threats by forgoing or delaying the opportunity to obtain rewards. In contrast, behavioral tasks designed to capitalize on the ability to actively choose to execute approach behaviors despite threats are scarce. Thus, we developed a behavioral test battery composed of three conflict tasks to directly study rats confronting threats to obtain rewards guided by innate and conditioned cues. One conflict task involves crossing a potentially electrified grid to obtain food on the opposite end of a straight alley, the second task is based on the step-down threat avoidance paradigm, and the third one is a modified version of the open field test. We used diazepam to pharmacologically validate conflict behaviors in our tasks. We found that, regardless of whether competing stimuli were conditioned or innate, a low diazepam dose decreased risk assessment and facilitated taking action to obtain rewards in the face of threats during conflict, without affecting choice behavior when there was no conflict involved. Using this pharmacologically validated test battery of ethologically designed innate/learned conflict tasks could help understand the fundamental brain mechanisms underlying the ability to confront threats to achieve goals.

Medial prefrontal cortical control of reward- and aversion-based behavioral output: Bottom-up modulation.

How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward- and aversion-based learning, which ultimately drive behavior. Though, cortical projections and modulatory systems that may regulate those processes in the mPFC are less understood. How does the mPFC regulate approach-avoidance behavior in the case of conflicting aversive and appetitive stimuli? This is likely dependent on the bottom-up neuromodulation of the mPFC projection neurons. In this review, we integrate behavioral-, pharmacological-, and viral-based circuit manipulation data showing the involvement of mPFC dopaminergic, noradrenergic, cholinergic, and serotoninergic inputs in reward and aversion processing. Given that an incorrect balance of reward and aversion value could be a key problem in mental diseases such as substance use disorders, we discuss outstanding questions for future research on the role of mPFC modulation in reward and aversion.

Affective spatial compatibility task(AFFSCT): theory and applications / Tarefa de compatibilidade espacial afetiva (TCEA): teoria e aplicações / Tarea de compatibilidad espacial afectiva (TCEA): teoría y aplicaciones

Emotional stimuli are processed very efficiently, influencing physiological and behavioral responses as well as attention, perceptual processes and sensory-motor integration. In a previous work, we introduced a new paradigm, the Affective Spatial Compatibility task (AffSCt), to study whether the affective valence of the stimulus influences spatial compatibility effects. By using figures of soccer players of Favorite and Rival Teams as positive and negative valence stimuli, we found a normal Spatial Compatibility effect for the Favorite team and a reversed one for the Rival team. Here, we analyzed the time course of inhibitory and facilitatory effects of emotional valence by the Vincentization method. We found that for Favorite team, the facilitatory effect for the compatible condition, as compared to the incompatible one, increases as a function of the reaction time. In contrast, for Rival team, an opposite trend was found, in which inhibitory effect beEmotional stimuli are processed verycomes stronger for slower responses. We suggest that AffSCt is a powerful technology for investigating approach/avoidance effects and that it may be useful for diagnosing and following up the treatment of affective and behavioral disorders, such as anxiety, panic and ADHD. Potential applications in social psychology and consumer studies are also considered.(AU).

Os estímulos emocionais são processados de forma muito eficiente, influenciando as respostas fisiológicas e comportamentais, bem como a atenção, a percepção e a integração sensório-motora. Em um trabalho anterior, propusemos um novo paradigma, a Tarefa Afetiva de Compatibilidade Espacial (AffSCt), para estudar se a valência afetiva do estímulo influenciaria os efeitos de compatibilidade espacial. Ao usarmos figuras de jogadores de futebol dos times Favorito e Rival como estímulos de valência positiva e negativa, respectivamente, encontramos um efeito de compatibilidade espacial normal para o time Favorito e um invertido para o time Rival. No presente trabalho, foi analisado o desenvolvimento temporal dos efeitos inibitórios e facilitatórios da valência emocional pelo método da Vincentização. Descobrimos que, para o time Favorito, o efeito facilitatório na condição compatível em relação à incompatível aumenta em função do tempo de reação. Em contraste, para o time Rival, uma tendência oposta foi encontrada, em que o efeito inibitório se torna mais forte para as respostas mais lentas. Sugere-se que a AffSCt é uma tecnologia poderosa para investigar comportamentos de aproximação/afastamento, podendo ser útil na avaliação diagnóstica e acompanhamento terapêutico de transtornos emocionais e comportamentais, como o de ansiedade generalizada, síndrome de pânico e transtorno do déficit de atenção/hiperatividade. Também são consideradas as aplicações potenciais em psicologia social e estudos de consumidor.(AU).

Los estímulos emocionales se procesan de manera muy eficiente e influyen en las respuestas fisiológicas y de comportamiento, así como en la atención, la percepción y la integración sensorio-motora. En un trabajo previo, que presentó un nuevo paradigma, la tarea afectiva de compatibilidad espacial (AffSCt), para estudiar si la valencia afectiva de los estímulos influyen en los efectos de la compatibilidad espacial. Mediante el uso de las figuras de los jugadores de fútbol de los equipos favorito e rival como estímulos positivo y negativo de valencia, respectivamente, se observó un efecto ordinario de compatibilidad espacial para el equipo favorito y un efecto invertido para el equipo rival. En este estudio, hemos examinado la evolución temporal de los efectos inhibitorios y facilitatorio de la valencia emocional por el uso de la Vincentización. Hemos encontrado que, para el equipo favorito, el efecto facilitatorio aumenta para la condición compatible, respecto la incompatible, con el tiempo de eacción. En contraste, para el equipo rival, una tendencia inversa se encontró, en el que el efecto inhibidor se vuelve más fuerte para las respuestas más lentas. Se sugiere que AffSCt es una poderosa tecnología para investigar los comportamientos de aproximación/retirada que puede ser útil para diagnosticar y seguir el tratamiento de trastornos afectivos y conductuales como ansiedad, pánico y déficit de atención/trastorno de hiperactividad. También son consideradas aplicaciones potenciales del método en la psicología social y en los estudios de consumo.(AU).

Affective spatial compatibility task(AFFSCT): theory and applications / Tarefa de compatibilidade espacial afetiva (TCEA): teoria e aplicações / Tarea de compatibilidad espacial afectiva (TCEA): teoría y aplicaciones

Emotional stimuli are processed very efficiently, influencing physiological and behavioral responses as well as attention, perceptual processes and sensory-motor integration. In a previous work, we introduced a new paradigm, the Affective Spatial Compatibility task (AffSCt), to study whether the affective valence of the stimulus influences spatial compatibility effects. By using figures of soccer players of Favorite and Rival Teams as positive and negative valence stimuli, we found a normal Spatial Compatibility effect for the Favorite team and a reversed one for the Rival team. Here, we analyzed the time course of inhibitory and facilitatory effects of emotional valence by the Vincentization method. We found that for Favorite team, the facilitatory effect for the compatible condition, as compared to the incompatible one, increases as a function of the reaction time. In contrast, for Rival team, an opposite trend was found, in which inhibitory effect beEmotional stimuli are processed verycomes stronger for slower responses. We suggest that AffSCt is a powerful technology for investigating approach/avoidance effects and that it may be useful for diagnosing and following up the treatment of affective and behavioral disorders, such as anxiety, panic and ADHD. Potential applications in social psychology and consumer studies are also considered.

Os estímulos emocionais são processados de forma muito eficiente, influenciando as respostas fisiológicas e comportamentais, bem como a atenção, a percepção e a integração sensório-motora. Em um trabalho anterior, propusemos um novo paradigma, a Tarefa Afetiva de Compatibilidade Espacial (AffSCt), para estudar se a valência afetiva do estímulo influenciaria os efeitos de compatibilidade espacial. Ao usarmos figuras de jogadores de futebol dos times Favorito e Rival como estímulos de valência positiva e negativa, respectivamente, encontramos um efeito de compatibilidade espacial normal para o time Favorito e um invertido para o time Rival. No presente trabalho, foi analisado o desenvolvimento temporal dos efeitos inibitórios e facilitatórios da valência emocional pelo método da Vincentização. Descobrimos que, para o time Favorito, o efeito facilitatório na condição compatível em relação à incompatível aumenta em função do tempo de reação. Em contraste, para o time Rival, uma tendência oposta foi encontrada, em que o efeito inibitório se torna mais forte para as respostas mais lentas. Sugere-se que a AffSCt é uma tecnologia poderosa para investigar comportamentos de aproximação/afastamento, podendo ser útil na avaliação diagnóstica e acompanhamento terapêutico de transtornos emocionais e comportamentais, como o de ansiedade generalizada, síndrome de pânico e transtorno do déficit de atenção/hiperatividade. Também são consideradas as aplicações potenciais em psicologia social e estudos de consumidor.

Los estímulos emocionales se procesan de manera muy eficiente e influyen en las respuestas fisiológicas y de comportamiento, así como en la atención, la percepción y la integración sensorio-motora. En un trabajo previo, que presentó un nuevo paradigma, la tarea afectiva de compatibilidad espacial (AffSCt), para estudiar si la valencia afectiva de los estímulos influyen en los efectos de la compatibilidad espacial. Mediante el uso de las figuras de los jugadores de fútbol de los equipos favorito e rival como estímulos positivo y negativo de valencia, respectivamente, se observó un efecto ordinario de compatibilidad espacial para el equipo favorito y un efecto invertido para el equipo rival. En este estudio, hemos examinado la evolución temporal de los efectos inhibitorios y facilitatorio de la valencia emocional por el uso de la Vincentización. Hemos encontrado que, para el equipo favorito, el efecto facilitatorio aumenta para la condición compatible, respecto la incompatible, con el tiempo de eacción. En contraste, para el equipo rival, una tendencia inversa se encontró, en el que el efecto inhibidor se vuelve más fuerte para las respuestas más lentas. Se sugiere que AffSCt es una poderosa tecnología para investigar los comportamientos de aproximación/retirada que puede ser útil para diagnosticar y seguir el tratamiento de trastornos afectivos y conductuales como ansiedad, pánico y déficit de atención/trastorno de hiperactividad. También son consideradas aplicaciones potenciales del método en la psicología social y en los estudios de consumo.