Oncocitoma quístico papilar de carúncula lagrimal

La carúncula lagrimal forma parte de los anexos oculares y es asiento ocasional de neoplasias, las cuales en su mayoría son benignas. Dentro de estos tumores se encuentran los oncocitomas, los cuales están constituidos por células oncocíticas (oxifílicas) y poseen una baja incidencia con menos del 3 % de los tumores y bajos reportes de casos en la literatura. A pesar de que existen varios estudios en Cuba de tumores de anexos oculares no hay evidencia actualizada de casos con oncocitoma. Por ello se considera necesaria la presentación de este caso. Se trata de paciente blanca, femenina de 83 años de edad con antecedentes de hipertensión arterial, compensada bajo tratamiento y de carcinoma basocelular, operada hace siete años. Acudió por presentar aumento de volumen indoloro en el ángulo interno del ojo izquierdo. Al examen físico oftalmológico se observó lesión de 1 cm, gris-rosácea, bien delimitada. Se procedió a su exéresis con sospecha clínica de carcinoma basocelular y se envió espécimen para estudio anatomopatológico, el cual concluyó como oncocitoma quístico papilar (cistoadenoma papilar eosinofílico) de carúncula.

The lacrimal caruncle is part of the ocular adnexa and is the occasional seat of neoplasms, most of which are benign. Among these tumors are oncocytomas, which are constituted by oncocytic (oxyphilic) cells and have a low incidence with less than 3% of tumors and low case reports in the literature. Although there are several studies in Cuba of ocular adnexal tumors, there is no updated evidence of cases with oncocytoma. Therefore, it is considered necessary to present this case. The patient is a white, 83-year-old female with a history of arterial hypertension, compensated under treatment and basal cell carcinoma, operated seven years ago. She presented with painless enlargement of the inner corner of the left eye. Ophthalmologic physical examination revealed a 1 cm lesion, grayish-pinkish, well demarcated. The lesion was excised with clinical suspicion of basal cell carcinoma and the specimen was sent for anatomopathologic study, which concluded as papillary cystic oncocytoma (eosinophilic papillary cystoadenoma) of the caruncle.

Oncocitoma em carúncula: relato de caso / Oncocytoma of the caruncle: a case report

RESUMO O oncocitoma é um tipo de neoplasia rara na prática clínica e descrito na literatura, principalmente quando localizado no olho. Quando localizado nos anexos oculares, é mais frequentemente na carúncula. Analisou-se o caso de uma paciente de 74 anos, caucasiana, que relatou desconforto visual no olho esquerdo, e cujo exame físico mostrou lesão tumoral na carúncula esquerda, com volume moderado, presença de neovascularização e secreção excessiva. A excisão cirúrgica da lesão foi realizada sob sedação, e a peça foi enviada para avaliação anatomopatológica. A lesão foi diagnosticada histologicamente como oncocitoma, sem malignidade, e a paciente não apresentou recidiva após o procedimento. Embora raro, esse tumor deve ser reconhecido pelos oftalmologistas, devido ao risco já relatado de desenvolvimento de adenocarcinoma.

ABSTRACT Oncocytoma is a neoplasm rarely observed in clinical practice and reported in the literature, especially when located in the eye. When described in the ocular adnexa, it is most often located in the caruncle. The case of a 74-year-old Caucasian female patient is reported. She complained of visual discomfort in the left eye, and physical examination showed a tumoral lesion in the left caruncle, of moderate volume, presence of neovascularization, and excessive secretion. Surgical excision of the lesion was performed under sedation, and the specimen was sent for pathological examination. The lesion was histologically diagnosed as oncocytoma with no malignancy, and the patient presented no recurrence after the procedure. Although rare, this tumor must be recognized by ophthalmologists due to the risk of developing adenocarcinoma, as already reported.

Study of morphological structure in human fetus Wharton's duct opening area.

OBJECTIVES: Not many morphological studies have been reported regarding the human salivary main duct, especially those based on observations of the fetal salivary main duct at various developmental stages. The relationships between fetal structural development and its function, functional disorders and diseases certainly have clinical significance. METHODS: In this study, we conducted a morphological observation of seven 5-9 month old human fetal sublingual caruncula, the common opening between the submandibular (Wharton's) duct and the sublingual (Bartholin's) duct. After seven specimens were removed and paraffin sections were prepared, HE and EVG staining were used for histological study of structural differences in the various developmental stages. Furthermore, anti-α-SMA staining was used to observe the distribution of the smooth muscle inside of the Wharton's duct wall. RESULTS: An abundance of elastic fibers were observed in the duct walls of both five and nine month old specimens with EVG staining. The smooth muscle fibers of five month old fetus were immature and were starting to distribute throughout the duct wall, whereas nine month old fetus' smooth muscle fibers were further developed and composed in layers. CONCLUSION: In this study, we confirmed that the Wharton's duct wall structure of nine month old fetuses was close to its adult structural formation, while the inner structure consisted of an ample distribution of elastic fibers and smooth muscle fibers. Based on the distribution pattern of the smooth muscle, we speculate that the Wharton's duct's opening area does not possess a sphincter-like function in the regulation of salivary flow.

Thuya occidentalis 12 ch como variante de tratamiento de la carúncula uretral en Pinar del Río. Enero 2000 - diciembre 2005 / Thuja occidentalis 12ch as an option of treatment in urethral caruncule in Pinar del Rio- January 2000-December 2005

La Carúncula uretral es una enfermedad femenina. Hasta el momento actual, la indicación eficaz de tratamiento es el proceder quirúrgico o largos períodos de tratamientos estrogénicos. Se realizó estudio prospectivo, descriptivo analítico longitudinal, desde enero del año 2000 hasta diciembre del 2005, a un grupo de 46 pacientes, en el HCQ "León Cuervo Rubio" de Pinar del Río, con el objetivo de validar la aplicación de un medicamento homeopático, Thuya Occidentalis 12 CH, que entre otras indicaciones según patogenesia, tiene la de actuar sobre formaciones polipoideas o estructuras semejantes a la Carúncula uretral. Fue utilizada la estadística descriptiva y como método estadístico la media porcentual para el análisis de los resultados. Se encontró en el grupo coincidencia con la literatura en cuanto a edad y síntomas de presentación. Se magnifica el resultado de desaparición de la lesión antes de las tres semanas en el 92,8% de las pacientes El 85,7% de las pacientes sobrepasa el año de evolución sin aparición de recidivas del tumor y sus síntomas acompañantes. Se convierte en un tratamiento eficiente, no invasivo, aporta un método de diagnóstico diferencial con otras entidades.

Urethral Caruncle is a female disease. Even in current times the most effective treatments are surgical approach or long-term periods of estrogen. A prospective, descriptive, analytic-longitudinal study from January 2000 to December 2005 was carried out in a group of 46 patients at "León Cuervo Rubio" Hospital in Pinar del Río, aimed at validating the use of the homeopathic drug Thuya occidentalis 12 CH, that among other indications and according to the pathogeny, acts on polypoid formations or structures similar to urethral caruncle. Descriptive statistics was used, and percentage mean was taken as a statistic method to analyze the results; coinciding age and symptoms of presentation with medical literature. The result of the disappearence of the lesion was significant before three weeks in 92,8% of the cases, 85,9% of them surpass one year without relapses of the tumor or its symptoms. Becoming an efficient, non-invasive treatment and provinding a method of differential diagnosis with other entities.