Metabolic Disturbances in a Mouse Model of MPTP/Probenecid-Induced Parkinson's Disease: Evaluation Using Liquid Chromatography-Mass Spectrometry.

Purpose: Parkinson's disease (PD) is a common neurodegenerative disease that severely affects patients' daily lives and places a significant burden on the global economy. There are currently no specific biomarkers for distinguishing between the different stages of PD. Methods: We divided 78 mice into six equal groups, including five model PD groups (W1-W5; based on the PD stage induced by length of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/propofol induction time) and a control group. Then, we used metabolomics technology to detect the serum small-molecule metabolites present in each group. Ultimately, we screened for potential biomarkers using the variable importance in the projection of the orthogonal partial least squares discriminant analysis and the coefficient value of LASSO ordinal logistic regression. Results: We identified 12 potential biomarkers, including dehydroepiandrosterone sulfate, pipecolic acid, N-acetylleucine, 2-aminoadipic acid, L-tyrosine, uric acid, and 5-hydroxyindoleacetaldehyde. Pathway analysis revealed their involvement in amino acid metabolism, caffeine metabolism, steroid hormone biosynthesis, and purine metabolism. Additionally, the receiver operating characteristic curve indicated that a biomarker panel comprising the 12 biomarkers could differentiate between the different PD stages. Conclusion: Different PD stages are characterized by different metabolites. The biomarkers identified in this study are helpful to understand the PD process.

Familial renal glycosuria identified in an Indian family.

Glycosuria can be isolated or it can be associated with other tubulopathies like proximal renal tubular acidosis, Fanconi syndrome and endocrine conditions like diabetes mellitus. The SLC5A2 gene codes for the SGLT2 transporter, which is responsible for glucose reabsorption in the proximal tubule. Previously reported cases show that mutation in this gene is associated with intellectual disability, seizure disorder and renin and angiotensin system dysfunction. In his early childhood, a male child displayed persistently high urine glucose levels. We ruled out diabetes mellitus and other tubulopathies before diagnosing the child with familial renal glycosuria, with a novel mutation in the SLC5A2 gene, and screened family members for the same condition. Child's father was found to have isolated renal glycosuria and tested positive for mutation in the SLC5A2 gene.

Circadian disturbances, anxiety and motor disturbances differentiate delirium superimposed on dementia from dementia-only.

Background: To ensure adequate treatment, individuals with delirium superimposed on dementia (DSD) need to be differentiated reliably from those with dementia only (DO). Therefore, we aimed to examine the clinical indicators of DSD by assessing motor subtypes, cognitive performance and neuropsychiatric symptoms in DSD and DO patients. Methods: Cross-sectional design with the Delirium-Motor-Subtyping Scale (DMSS), Mini-Mental-State-Examination (MMSE), Clock-Drawing-Test (CDT), DemTect, and Neuropsychiatric Inventory assessed after admission to an acute hospital. Results: 94 patients were included, 43 with DSD (78 ± 7 years, MMSE = 11 ± 9) and 51 with DO (79 ± 7 years, MMSE = 9 ± 8). DMSS "no subtype" was more common in the DO group (26% vs. 10%, p = .04). The DSD group showed lower CDT scores (DSD: M = 4 ± 3 vs. DO: M = 6 ± 1; p < .001) and higher anxiety (DSD: MED = 3 ± 8 vs. DO: MED = 3 ± 4; p = .01) and sleep/night-time behavior disturbances (DSD: MED = 0 ± 6 vs. DO: MED = 0 ± 0; p = .02). Conclusions: Sleep/night-time behavior disturbances appear to be a clinical indicator of DSD. Motor subtypes can identify cases at increased risk of developing delirium or unrecognized delirium. Clinical trial registration: https://drks.de/search/de/trial/DRKS00025439, identifier DRKS00025439.

Unusual presentation of Wilson's disease as proximal renal tubular acidosis with isolated phosphaturia.

An adolescent girl presented with recurrent lower limb fractures and was managed as osteogenesis imperfecta. Low phosphate levels noted on routine investigation were the clue for the phosphaturia and subsequent diagnosis of proximal renal tubular acidosis (RTA). Further, with a history of jaundice, she was diagnosed with Wilson's disease, which was the underlying cause of proximal RTA with isolated phosphaturia and consequent fractures. Standard treatment for Wilson's disease along with supplementation of oral phosphate and bicarbonate led to complete recovery of fragile bones.

Association between sleep disturbances and challenging behavior in children and adolescents with Angelman syndrome.

Angelman Syndrome (AS) is a neurodevelopmental disorder with severe symptoms and associated comorbidities. It is caused by the inactivity or lack of the UBE3a gene. Symptoms of the syndrome include intellectual disability and developmental delay. The current study investigated sleep disturbances (SD) in children and adolescents with AS, associations between SD and possible predictors of SD. Variables examined included age, gender, newborn and infancy history, challenging behavior, type of therapy received, genetic type of AS, and seizures. The sample included data from 109 participants with a mean age of 8.21, accessed via the Global Angelman Syndrome Registry. Chi-square tests were carried out to assess the associations between the variables and a logistical regression was carried out to assess the possible predictors of SD. Associations were found between SD and certain repetitive behaviors: slapping walls, focal hand movements, and agitation at new situations. From these associations, a regression formed a predictive model for sleep disturbances. The findings of this research demonstrated the importance of investigating the relationship between sleep disturbances and challenging behavior in children and adolescents with AS and the need for further research in this area.

Sleep disorder syndromes of post-acute sequelae of SARS-CoV-2 (PASC) / Long Covid.

INTRODUCTION: COVID-19 infection has resulted in a high prevalence of a post-infectious syndrome, known as post-acute sequelae of SARS-CoV-2 (PASC) or "Long COVID". PASC is a heterogeneous disease with a high prevalence of sleep disturbances, varying from an insomnia disorder to excessive daytime sleepiness. METHODS: Patients seen in the Covid Survivorship Program at the Beth Israel Deaconess Medical Center Boston, USA, were screened for sleep disorders as part of a comprehensive multi-system evaluation. Those who screened positive were referred for a comprehensive sleep evaluation in a dedicated COVID-19-Sleep clinic, followed by diagnostic sleep testing and treatment. This report summarizes patients who completed an American Academy of Sleep Medicine (AASM) accredited facility-based diagnostic evaluation. International Classification of Sleep Disorders 3rd Edition-Revised criteria were met for all diagnoses. RESULTS: In 42 patients with PASC, five categories of sleep disorder syndromes were observed following a sleep clinic evaluation, including obstructive sleep apnea, chronic insomnia disorder, primary hypersomnia, REM behavior disorder (RBD), and new onset circadian phase delay. Seven patients met criteria for idiopathic hypersomnia, and two had narcolepsy type 2. RBD patients were infected in three different waves; circadian disturbance patients were all infected in the winter wave of 2020/21, and the primary hypersomnolence group occurred during all waves, predominantly the initial wave of 2020. A peculiar form of insomnia was a persistent loss of sleep regularity. CONCLUSIONS: Specific sleep symptoms/syndromes are reported in this select group of patients with PASC/Long Covid. As new onset sleep complaints are prevalent in PASC, we recommend a complete clinical and investigative sleep evaluation for persistent severe sleep symptoms following COVID-19 infection.

Ecological networks in savannas reflect different levels of hydric stress in adjacent palm swamp forest ecosystems.

Palm swamp forests are wetland ecosystems typical of the Brazilian Cerrado, which in recent decades have undergone intense changes due to land use alterations and climate change. As a result of these disturbances, many palm swamps have been experiencing significant drying, which can also affect adjacent vegetation. In the present study, we evaluated whether the drying of palm swamps affects the structure of plant-herbivore networks located in adjacent savanna areas in Brazil. Our results show that savanna areas adjacent to dry zones of palm swamps have fewer interactions, fewer interacting species, and a less specialized topology, which corroborates our expectations. Our findings indicate that the drying of palm swamps also has propagated impacts on adjacent savanna vegetation, impairing more specialized interactions in these environments. On the other hand, contrary to expectations, plant-herbivore networks in dry zones displayed higher modularity, lower nestedness and lower robustness than those in wet zones, suggesting that in dry environments, species tend to compartmentalize their interactions, even with lower interaction specialization. This is the first study to investigate the impacts of environmental drying on the structure of plant-herbivore networks in tropical ecosystems, highlighting the complexity of these effects and their differential impact on specialized and generalized interactions. Understanding these dynamics is crucial for developing effective conservation and management strategies in the face of ongoing environmental changes.

Therapeutic roles of coenzyme Q10 in peripheral nerve injury-induced neurosensory disturbances: Mechanistic insights from injury to recovery.

Peripheral nerve injuries (PNIs) are prevalent conditions mainly resulting from systemic causes, including autoimmune diseases and diabetes mellitus, or local causes, for example, chemical injury and perioperative nerve injury, which can cause a varying level of neurosensory disturbances (NSDs). Coenzyme Q10 (CoQ10) is an essential regulator of mitochondrial respiration and oxidative metabolism. Here, we review the pathophysiology of NSDs caused by PNIs, the current understanding of CoQ10's bioactivities, and its potential therapeutic roles in nerve regeneration, based on evidence from experimental and clinical studies involving CoQ10 supplementation. In summary, CoQ10 supplementation shows promise as a neuroprotective agent, potentially enhancing treatment efficacy for NSDs by reducing oxidative stress and inflammation. Future studies should focus on well-designed clinical trials with large sample sizes, using CoQ10 formulations with proven bioavailability and varying treatment duration, to further elucidate its neuroprotective effects and to optimize nerve regeneration in PNIs-induced NSDs.

Disrupted brain functional asymmetry at rest in patients with major depressive disorder associated with sleep disturbances.

Sleep disturbances (SD) are common in major depressive disorder (MDD) patients. Brain functional asymmetry is crucial for understanding MDD pathophysiology. Previous studies using the parameter of asymmetry (PAS) approach have found brain functional asymmetry disruption in MDD. However, this has not been explored in MDD patients with SD. This study examined 26 MDD patients with SD, 34 MDD patients without SD, and 34 healthy controls using resting-state functional magnetic resonance imaging scans. SD symptoms were quantified using the 17-item Hamilton Rating Scale for Depression. PAS approach was used to evaluate functional asymmetry. MDD patients with SD displayed increased PAS in the left middle frontal gyrus (MFG)/inferior frontal gyrus (IFG) and decreased PAS in the left parahippocampal gyrus (PHG) compared to MDD patients without SD. Increased PAS in the left MFG/IFG was positively correlated with SD severity, and a negative correlation was found between decreased PAS in the left PHG and SD scores in all MDD patients. Receiver operating characteristic analysis indicated that increased PAS in the left MFG/IFG and decreased PAS in the left PHG may serve as potential neuroimaging markers to differentiate MDD patients with SD from those without SD with Area Under Curve values of 0.8157 and 0.8068, respectively. These results highlighted that increased PAS in the left MFG/IFG and decreased PAS in the left PHG may be considered a prominent feature associated with SD symptoms of MDD patients, potentially serving as imaging markers to discriminate between MDD patients with and without SD.

Sleep-related measurements to assess sleep disturbances among people living with dementia in nursing homes: a systematic review.

BACKGROUND: There is a high prevalence of sleep disturbances among people living with dementia (PLWD) in nursing homes. Reliable and valid measurements are needed to assess these disturbances. The aim of this systematic review was to identify, analyze and synthesize studies of sleep-related measurements to assess sleep disturbances in PLWD. METHODS: The databases PubMed, CINAHL, and PsycINFO were systematically searched in 2019; the search was updated in March 2024. The inclusion criteria were as follows: participants with dementia or probable dementia in any care setting; and studies that reported at least one of the following aspects: (I) theoretical and conceptual frameworks, (II) user or patient involvement by type of users in measurement development, (III) feasibility and practicability of measurements, and (IV) results of psychometric analyses. The quality of the included studies was evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria and the quality appraisal tool for studies of diagnostic reliability (QAREL) tool. RESULTS: A total of 5169 studies were identified; ultimately, 15 studies describing three self-administered measurements, three proxy-administered measurements and two technological measurements were included. No sleep-related measurement showed acceptable psychometric properties in any of the COSMIN domains. CONCLUSIONS: No measurement without adaptation can be recommended for PLWD in nursing homes. If existing measurements are used in clinical practice, the self-perspective of PLWD should be taken into account. If this is no longer fully possible, proxy-rating perspectives in combination could be an option. Future research on sleep-related measurements should be strictly based on international consensus-based psychometric quality criteria.

Sleep disturbances and intrinsic capacity trajectories among Chinese older adults: The Rugao Longevity and Ageing Study.

Age related decline of intrinsic capacity (IC) is the core of the functional ability and risk factor of adverse outcomes such as disability, hospitalization, and mortality. However, the relationship between sleep disturbance and IC decline are largely unknown. We conducted a longitudinal study and used data of 1514 community elders from the aging arm of the Rugao Longevity and Ageing Study. We found that poor sleep quality is cross-sectional associated with an increased risk of lower IC. In longitudinal analysis, sleep disturbances were inversely associated with composite IC score changes after adjusting for confounders (PSQI>5 vs. PSQI≤5: mean difference [-0.23], P = 0.0005), suggesting that poor sleep quality was associated with a decline in IC during the follow-up period. In conclusion, sleep disturbances were associated with worse IC changes. The results suggest that improving sleep health may help prevent IC decline and hence decreasing the burden of geriatric nursing practice.

Correlation of Co-Morbidities with Symptom Severity of Children with Autism Spectrum Disorder: A Cross-Sectional Survey.

This study aims to identify potential correlations of the severity of symptoms of children with autism spectrum disorder (ASD) with serum nutritional levels, body composition indicators, diet partiality, and sleep disturbances. The cohort of this cross-sectional study included 120 children with ASD and 110 typically developing (TD) children to assess symptoms of ASD, and to measure serum levels of vitamins and minerals and the body composition values. Diet partiality and sleep disturbances were assessed by administering questionnaires. The serum levels of folic acid, copper, and vitamin B were lower in children with ASD than in TD children, while magnesium and homocysteine were higher (p < 0.05). Children with ASD had greater chest circumference, abdominal skinfold thickness, and body mass index (BMI) than TD children (p < 0.05), and higher prevalences of diet partiality and sleep disturbances (p < 0.001). Lower vitamin A levels and higher vitamin D levels were related to social impairment in children with ASD. Moreover, there were significantly positive correlations of BMI, chest circumference, diet partiality, and sleep disturbances with severity of ASD symptoms (p < 0.05). Collectively, rational nutritional supplementation, dietary management, and behavioral interventions are essential for children with ASD.

Mapping annual dynamics of surface mining disturbances in the northeastern Tibetan Plateau using Landsat imagery and LandTrendr algorithm.

The exploitation and utilization of coal resources have significantly contributed to global energy security. However, this mining activity has inflicted considerable damage on the ecological environment, particularly on the Tibetan Plateau, where the impact on ecosystems may be even more detrimental. The implementation of high-intensity mining activities leads to rapid changes in land cover/land use. Consequently, it is essential to accurately and effectively monitor mining disturbances. In this study, we propose an approach to capture surface mining disturbances using spatial-temporal rules and time series stacks of Landsat data. First, a time series of annual mining disturbance probability was generated based on Landsat temporal-spectral metrics and random forest. Second, the Landsat-based detection of Trends in Disturbance and Recovery (LandTrendr) algorithm was employed to segment the time series and detect breakpoints. Finally, mining disturbances were captured by further restricting the output of LandTrendr based on spatial-temporal rules of mining disturbances. This approach was applied and evaluated in the Muli mining area of the northeastern Tibetan Plateau, which experienced large-scale and rapid mining disturbances from 2004 to 2014, and identified a disturbed mining area of 43.62 km2. The mining sites have been reclaimed after mining, and all reclamation work was done after 2016, with a total reclaimed area of 22.28 km2. The validation results indicated that the overall accuracy of mining disturbance and reclamation mapping ranges from 0.7333 to 0.8667, and the F1 scores for mining disturbances and reclamation range from 0.7551 to 0.8723. This study provides a reliable framework for monitoring mining disturbances and reclamation in surface mines, promising to be useful in realizing disturbance monitoring in surface mines for a wide range of mineral types.

Mother-child bond and its relationship with maternal postpartum depression.

BACKGROUND: The mother-child bond may be related to maternal health, especially postpartum depression (PPD). Existing studies show the need for further in-depth research on the subject. AIM: To determine the relationship between bonding and the probability of the development and presence of PPD in women with a biological child between 6 weeks and 18 months of age. METHODS: A cross-sectional study was conducted. A questionnaire containing sociodemographic, psychosocial, and health variables referring to the mother and the newborn, a questionnaire measuring the mother-child bond (VAMF-bond), and the Edinburgh Postpartum Depression Scale (EDPS) were administered. RESULTS: 1114 women participated. The association between the items of the VAMF-bond subscale and the risk of PPD was statistically significant for all items (p < 0.05), except items 4 and 10. The multivariate analysis showed that the risk of PPD (EPDS scale) was lower in women with higher scores on bond (Adjusted Odds Ratio: aOR = 0.85; 95%CI: 0.81, 0.88), whose birth experience was good or very good (aOR = 0.57; 95%CI: 0.36, 0.89), who received high or very high support from their partner (aOR = 0.34; 95%CI: 0.18, 0.66), and family (aOR = 0.53; 95%CI: 0.32, 0.86). The presence of PPD was less frequent in women who presented higher scores for bond (aOR = 0.90; 95%CI: 0.84, 0.97), who had skin-to-skin contact (aOR = 0.39; 95%CI: 0.17, 0.93) and who received high or very high support from the family (aOR = 0.36; 95%CI: 0.12, 1.04). CONCLUSIONS: High scores on the subscale VAMF-bond were associated with a lower risk of PPD.

Prevalence of sleep disorders in geriatrics: an exploratory study using sleep questionnaires.

OBJECTIVES: This study aimed to investigate the prevalence of sleep problems in older subjects, considering sex and age differences. METHODS: Subjects admitted to a geriatrics clinic underwent a medical visit and completed a battery of questionnaires assessing sleep quality, insomnia, sleep apnea risk, excessive daytime sleepiness (EDS), restless legs syndrome (RLS), chronotype, depression and global cognition. RESULTS: Fifty-eight subjects (58.6 % women, mean age 77.36±6.07) were included. The most predominant sleep-related complaint was poor sleep quality (36.2 %), followed by sleep apnea risk (34.5 %), insomnia symptoms (25.9 %), EDS (15.5 %) and RLS (12.1 %). Older women reported more insomnia, poorer sleep quality and depressive symptoms than males. Patients aged ≥ 75 years old had more comorbidities and higher sleep apnea risk compared to those under 75 years old. CONCLUSIONS: Sleep problems are frequent in older adults, requiring their screening and treatment for possibly improving well-being and reduce the burden of neuropsychiatric and medical comorbidities.

Relación entre la calidad de sueño y somnolencia diurna en estudiantes universitarios / Sleep quality and daytime sleepiness in university students / Qualidade do sono e sonolência diurna em estudantes universitários

Los estudiantes universitarios están propensos a sufrir alteraciones en el sueño como la somnolencia diurna, lo cual tiene repercusión directa en su calidad de vida y desempeño diario. Objetivo. Determinar la relación entre la calidad de sueño y somnolencia diurna en estudiantes de la Universidad nombre, en Perú. Materiales y Métodos. Se consideró el enfoque cuantitativo, de diseño no experimental, con la aplicación de los instrumentos de calidad del sueño de Pittsburgh y la escala de somnolencia Epworth. La población fue de 446 estudiantes y se obtuvo una muestra de 220 estudiantes universitarios, mediante un muestreo no probabilístico. Resultados. Se presentan severos problemas en relación a la calidad del sueño en un 60,9 %; así como en la calidad subjetiva del sueño en un 49,5 %, duración del sueño en un 54,5 %, uso de medicación hipnótica en un 56,8 %, disfunción diurna 50,5 %; y la latencia del sueño, eficiencia de sueño habitual y alteraciones del sueño en un 57,7 %. Entre tanto, la somnolencia diurna fue alta en un 58,6 %. Conclusiones. Existe relación positiva y significativa entre la calidad del sueño y la somnolencia diurna en los alumnos de la Universidad nombre, alcanzando una ρ = 0.000 (ρ < 0.05); del mismo modo se encontró relación significativa en cada una de las dimensiones de la calidad del sueño y la somnolencia diurna; de lo que se interpreta que la calidad del sueño de problemas de nivel leve, la somnolencia diurna se encuentra en niveles bajos en los universitarios.

University students are prone to sleep disturbances such as daytime sleepiness, which has a direct impact on their quality of life and daily performance. Objective. Determine the relationship between sleep quality and daytime sleepiness in students at the Universidad Nombre, in Peru. Materials and methods. The quantitative approach was considered, with a non-experimental design, with the application of the Pittsburgh sleep quality instruments and the Epworth sleepiness scale. The population was 446 students and a sample of 220 university students was obtained, through non-probabilistic sampling. Results. There are severe problems in relation to sleep quality in 60.9 %; as well as in the subjective quality of sleep in 49.5 %, duration of sleep in 54.5 %, use of hypnotic medication in 56.8 %, daytime dysfunction 50.5 %; and sleep latency, habitual sleep efficiency and sleep disturbances by 57.7 %. Meanwhile, daytime sleepiness was high at 58.6 %. Conclusions. There is a positive and significant relationship between sleep quality and daytime sleepiness in the students of the Name University, reaching ρ = 0.000 (ρ < 0.05); Likewise, a significant relationship was found in each of the dimensions of sleep quality and daytime sleepiness; from which it is interpreted that the quality of sleep has mild problems, daytime sleepiness is at low levels in university students.

Os estudantes universitários são propensos a distúrbios do sono, como a sonolência diurna, o que tem impacto direto na sua qualidade de vida e no desempenho diário. Objetivo. Determinar a relação entre qualidade do sono e sonolência diurna em estudantes da Universidad Nombre, no Peru. Materiais e métodos. Considerou-se a abordagem quantitativa, com desenho não experimental, com aplicação dos instrumentos de qualidade do sono de Pittsburgh e da escala de sonolência de Epworth. A população foi de 446 estudantes e obteve-se uma amostra de 220 estudantes universitários, através de amostragem não probabilística. Resultados. Existem problemas graves em relação à qualidade do sono em 60,9 %; bem como na qualidade subjetiva do sono em 49,5 %, duração do sono em 54,5 %, uso de medicação hipnótica em 56,8 %, disfunção diurna 50,5 %; e latência do sono, eficiência habitual do sono e distúrbios do sono em 57,7 %. Enquanto isso, a sonolência diurna foi elevada, 58,6 %. Conclusões. Existe uma relação positiva e significativa entre a qualidade do sono e a sonolência diurna nos estudantes da Universidade do Nome, atingindo ρ = 0,000 (ρ <, 05); Da mesma forma, foi encontrada relação significativa em cada uma das dimensões da qualidade do sono e da sonolência diurna; a partir do qual se interpreta que a qualidade do sono apresenta problemas leves, a sonolência diurna é baixa em estudantes universitários.

Relación entre la calidad de sueño y somnolencia diurna en estudiantes universitarios

Los estudiantes universitarios están propensos a sufrir alteraciones en el sueño como la somnolencia diurna, lo cual tiene repercusión directa en su calidad de vida y desempeño diario. Objetivo. Determinar la relación entre la calidad de sueño y somnolencia diurna en estudiantes de la Universidad nombre, en Perú. Materiales y Métodos. Se consideró el enfoque cuantitativo, de diseño no experimental, con la aplicación de los instrumentos de calidad del sueño de Pittsburgh y la escala de somnolencia Epworth. La población fue de 446 estudiantes y se obtuvo una muestra de 220 estudiantes universitarios, mediante un muestreo no probabilístico. Resultados. Se presentan severos problemas en relación a la calidad del sueño en un 60,9 %; así como en la calidad subjetiva del sueño en un 49,5 %, duración del sueño en un 54,5 %, uso de medicación hipnótica en un 56,8 %, disfunción diurna 50,5 %; y la latencia del sueño, eficiencia de sueño habitual y alteraciones del sueño en un 57,7 %. Entre tanto, la somnolencia diurna fue alta en un 58,6 %. Conclusiones. Existe relación positiva y significativa entre la calidad del sueño y la somnolencia diurna en los alumnos de la Universidad nombre, alcanzando una ρ = 0.000 (ρ < 0.05); del mismo modo se encontró relación significativa en cada una de las dimensiones de la calidad del sueño y la somnolencia diurna; de lo que se interpreta que la calidad del sueño de problemas de nivel leve, la somnolencia diurna se encuentra en niveles bajos en los universitarios.

University students are prone to sleep disturbances such as daytime sleepiness, which has a direct impact on their quality of life and daily performance. Objective. Determine the relationship between sleep quality and daytime sleepiness in students at the Universidad Nombre, in Peru. Materials and methods. The quantitative approach was considered, with a non-experimental design, with the application of the Pittsburgh sleep quality instruments and the Epworth sleepiness scale. The population was 446 students and a sample of 220 university students was obtained, through non-probabilistic sampling. Results. There are severe problems in relation to sleep quality in 60.9 %; as well as in the subjective quality of sleep in 49.5 %, duration of sleep in 54.5 %, use of hypnotic medication in 56.8 %, daytime dysfunction 50.5 %; and sleep latency, habitual sleep efficiency and sleep disturbances by 57.7 %. Meanwhile, daytime sleepiness was high at 58.6 %. Conclusions. There is a positive and significant relationship between sleep quality and daytime sleepiness in the students of the Name University, reaching ρ = 0.000 (ρ < 0.05); Likewise, a significant relationship was found in each of the dimensions of sleep quality and daytime sleepiness; from which it is interpreted that the quality of sleep has mild problems, daytime sleepiness is at low levels in university students.

Os estudantes universitários são propensos a distúrbios do sono, como a sonolência diurna, o que tem impacto direto na sua qualidade de vida e no desempenho diário. Objetivo. Determinar a relação entre qualidade do sono e sonolência diurna em estudantes da Universidad Nombre, no Peru. Materiais e métodos. Considerou-se a abordagem quantitativa, com desenho não experimental, com aplicação dos instrumentos de qualidade do sono de Pittsburgh e da escala de sonolência de Epworth. A população foi de 446 estudantes e obteve-se uma amostra de 220 estudantes universitários, através de amostragem não probabilística. Resultados. Existem problemas graves em relação à qualidade do sono em 60,9 %; bem como na qualidade subjetiva do sono em 49,5 %, duração do sono em 54,5 %, uso de medicação hipnótica em 56,8 %, disfunção diurna 50,5 %; e latência do sono, eficiência habitual do sono e distúrbios do sono em 57,7 %. Enquanto isso, a sonolência diurna foi elevada, 58,6 %. Conclusões. Existe uma relação positiva e significativa entre a qualidade do sono e a sonolência diurna nos estudantes da Universidade do Nome, atingindo ρ = 0,000 (ρ < 0,05); Da mesma forma, foi encontrada relação significativa em cada uma das dimensões da qualidade do sono e da sonolência diurna; a partir do qual se interpreta que a qualidade do sono apresenta problemas leves, a sonolência diurna é baixa em estudantes universitários.

Prevalence of sleep disturbances among intensive care nurses: A systematic review and meta-analysis.

BACKGROUND: Demanding intensive care unit (ICU) work environments may lead to sleep disturbances in nurses, impacting their health and potentially patient safety. Yet, the prevalence remains unclear around the world. AIMS: To quantify the prevalence of sleep disturbances in intensive care nurses. STUDY DESIGN: Systematic review and meta-analysis. A database search was conducted in Embase, PubMed, Web of Science, Scopus and CINAHL from their inception to April 2024 for relevant studies. Data from observational studies (cross-sectional or cohort) that reported the prevalence of sleep disturbances, assessed using the Pittsburgh Sleep Quality Index (PSQI > 5), pooled in random-effects meta-analyses. Subgroup analyses were used to investigate variations in the prevalence estimates in terms of available variables. A Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA)-compliant protocol was registered in PROSPERO (CRD42023476428). RESULTS: In total, 24 articles were included in this study published from 1996 to 2023. Included studies were from 15 unique countries. Almost all of the studies were descriptive cross-sectional studies (n = 22; 91.7%). The included studies encompassed a range of intensive care nurses, from 42 to 605, involving a total of 3499 intensive care nurses. The reported proportion of intensive care nurses with sleep disturbances ranged from 20.0% to 100.0%, with a median of 76.7% (interquartile range: 62.9-85.7). The pooled prevalence of sleep disturbances in intensive care nurses was 75.1% (95% confidence interval: 37.2-53.1; 95% prediction interval: 30.5-95.4). CONCLUSIONS: Sleep disturbance is a common issue in intensive care nurses. The study results highlight the importance of implementing effective interventions as early as possible to improve ICU sleep quality. RELEVANCE TO CLINICAL PRACTICE: High prevalence of sleep disturbances among intensive care nurses necessitates global interventions. Gender-neutral approaches that acknowledge comparable risks and stable prevalence over time require long-term strategies. Raising awareness through programmes is vital for implementing evidence-based interventions to promote sleep health in intensive care nurses.