Treatment of Fordyce Spots with CO2 Laser: A Case Series of Three Patients.

The Fordyce spots are ectopic sebaceous glands, located at the lip's vermilion border or the oral mucosa. Clinically presents as tiny, discrete, white or yellowish, focally grouped papules. It is a common cosmetic disorder and is significantly associated with emotional stress. Herein, we describe three cases that showed satisfactory cosmetic results after the treatment of Fordyce spots using a CO2 laser. Patients were 21-year-old, 25-year-old, and 28-year-old males with Fordyce spots on the upper lip. They were treated with the CO2 laser and after 4 months of treatment, no recurrence was noted. Treatment with pinhole ablation with CO2 laser improves cosmetic results, reduces downtime, and minimizes side effects. To the best of our knowledge, no such case series have been reported to date from the Indian subcontinent.

Differentiating Fordyce Spots from Their Common Simulators Using Ultraviolet-Induced Fluorescence Dermatoscopy-Retrospective Study.

Fordyce spots (FS) are heterotopic sebaceous glands affecting mostly oral and genital mucosa, commonly misdiagnosed with sexually transmitted infections. In a single-center retrospective study, we aimed to assess the ultraviolet-induced fluorescencedermatoscopy (UVFD) clues of Fordyce spots and their common clinical simulants: molluscum contagiosum, penile pearly papules, human papillomavirus warts, genital lichen planus, and genital porokeratosis. Analyzed documentation included patients' medical records (1 September-30 October 2022) and photodocumentation, which included clinical images as well as polarized, non-polarized, and UVFD images. Twelve FS patients were included in the study group and fourteen patients in the control group. A novel and seemingly specific UVFD pattern of FS was described: regularly distributed bright dots over yellowish-greenish clods. Even though, in the majority of instances, the diagnosis of FS does not require more than naked eye examination, UVFD is a fast, easy-to-apply, and low-cost modality that can further increase the diagnostic confidence and rule out selected infectious and non-infectious differential diagnoses if added to conventional dermatoscopic diagnosis.

Assessment of Intraoral Findings of Neonates, Born in and around Meerut City.

AIM: The aim of this study is to evaluate the occlusal relationships between the gum pads of neonates and to record intraoral findings in neonates and compare with the existing findings. MATERIALS AND METHODS: The oral cavities of 1,000 healthy neonates from birth to 1 month of age were examined to evaluate the occlusal relationships between the gum pads and to record other intraoral findings in neonates and compare with the existing findings. Oral findings recorded were oral mucosal cysts, Fordyce's spot, Epstein's pearls, Bohn's nodules, ankyloglossia, natal or neonatal teeth and attachment of the upper midline frenum. Relationship between the alveolar ridges was also recorded. Obtained data were evaluated and statistically analyzed using the Statistical Package for Social Sciences (SPSS) version 21.0 and Epi-info version 3.0. RESULTS: The maxillo-mandibular relationship of gum pads in approximately 97% cases, the mandible was found distal and lingual to maxilla. The presence of anterior open bite was observed in 9.1% cases. The most common intraoral finding in examined neonates was an oral mucosal cyst, 61.2%. The presence of Epstein's pearls was the next most common finding 38.3%. Fordyce's spots were found only in 1.2% of cases, while the presence of natal/neonatal teeth was only in 0.6% of cases. Ankyloglossia was present in only 0.5% neonates. Maxillary frenum was present in 79.1% of cases and it was attached on the alveolar crest. CONCLUSION: The results of the present study were in accordance with the pre-existing data. However, anterior open-bite was seen in significantly less percentage of the population. HOW TO CITE THIS ARTICLE: Niranjan MM, Srivastava N, Rana V, et al. Assessment of Intraoral Findings of Neonates, Born in and around Meerut City. Int J Clin Pediatr Dent 2020;13(1):48-52.

A case of successful treatment of Fordyce spots with a single insulated microneedle radiofrequency device.

Fordyce spots are ectopic sebaceous glands which typically present as asymptomatic, multiple whitish, or yellowish 1-3-mm sized papules on the lips. Several therapeutic approaches have been proposed such as laser, electrical or chemical ablation, and micropunch excision. However, these modalities pose the risk of scarring from inevitable surface damage. In this report, we present a case of Fordyce spots which was successfully treated with intralesional electrocoagulation using a proximally insulated microneedle and monopolar radiofrequency device, resulting in marked cosmetic improvements without surface damage.

[About 2 cases of ectopic sebaceous glands in esophagus: Endoscopic and histological correlations from biopsies and resected specimens]. / À propos de 2 cas de glandes sébacées ectopiques œsophagiennes : corrélations endoscopiques, et anatomopathologiques sur biopsies et pièces opératoires.

Sebaceous glands are cutaneous annexes located in the dermis. Focal spots of ectopy of these glands are frequently identified in ectodermal tissues: they represent Fordyce's disease. However, only a few cases of ectopic sebaceous glands have been mentioned in non-ectodermic tissue. Fordyce spots of esophageal location are unusual, and most of them have been diagnosed from biopsy specimens. We report two cases of ectopic sebaceous glands in esophagus, the first diagnosed from a resected specimen, the second from biopsies. A literature review is carried out.

Can presence of oral Fordyce's granules serve as a marker for hyperlipidemia?

BACKGROUND: Hyperlipidemia is a well-documented risk factor for coronary heart disease and a great wealth of clinical trials have shown that early detection of hyperlipidemia and prescribing drugs that lower elevated lipid levels reduce serious cardiovascular events, such as myocardial infarction, heart failure and stroke. Fordyce granules (FGs) are sebaceous glands without hair follicles, most often located under the epithelium of the cheek and the vermilion border of lip. The incidence of FGs is typically high and their presence is usually regarded as a normal variation of the oral mucosa. The aim of this study was to investigate the pattern of anatomical distribution and density of FGs and also to explore any potential relationship between the detection of FGs and the state of hyperlipidemia. MATERIALS AND METHODS: A cross-sectional, prospective study was designed. The participants were divided into two groups; first group consisted of individuals with FGs and the second group included those with no FGs detected. All participants were fasting 9-12 h before they were subjected to a comprehensive oral examination and their blood was sampled and tested for complete lipid profile. The presence of FGs was scored based on the number of the granules and their anatomical distribution. Chi-square test was used and P < 0.05 was considered as significant. RESULTS: A total of 350 patients were recruited for this study, nearly 90% (n = 314) elicit detectable FGs. The FGs were mainly located on the buccal mucosa with or without labial involvement and their density tend to reduce with age and also with smoking. Individuals with elevated lipid profile tend to have the highest score of the FGs. CONCLUSION: According to this report, the presence of high numbers of FGs in people with high risk factors for cardiovascular disease should not be neglected.