In-silico green toxicology approach toward discovering safer ligands for development of safe-by-design metal-organic frameworks.

A vast variety of chemical compounds have been fabricated and commercialized, they not only result in industrial exposure during manufacturing and usage, but also have environmental impacts throughout their whole life cycle. Consequently, attempts to assess the risk of chemicals in terms of toxicology have never ceased. In-silico toxicology, also known as predictive toxicology, has advanced significantly over the last decade as a result of the drawbacks of experimental investigations. In this study, ProTox-III was applied to predict the toxicity of the ligands used for metal-organic framework (MOF) design and synthesis. Initially, 35 ligands, that have been frequently utilized for MOF synthesis and fabrication, were selected. Subsequently, canonical simplified molecular-input line-entry system (SMILES) of ligands were extracted from the PUBCHEM database and inserted into the ProTox-III online server. Ultimately, webserver outputs including LD50 and the probability of toxicological endpoints (cytotoxicity, carcinogenicity, mutagenicity, immunotoxicity, and ecotoxicity) were obtained and organized. According to retrieved LD50 data, the safest ligand was 5-hydroxyisophthalic. In contrast, the most hazardous ligand was 5-chlorobenzimidazole, with an LD50 of 8 mg/kg. Among evaluated endpoints, ecotoxicity was the most active and was detected in several imidazolate ligands. This data can open new horizons in design and development of green MOFs.

Occupational exposures to asbestos in the steel industry: An analysis of the AISI sampling campaign (1989-1997).

The American Iron and Steel Institute (AISI) gathered data between 1989 and 1997 to build an "objective database" to further understand the occupational exposures generated by the few asbestos-containing materials remaining at various steelmaking companies at this time. This paper analyzed the 520 samples from this campaign which occurred at five different steel manufacturers: Georgetown Steel Company, Inland Steel Company, Ling-Temco-Vought (LTV) Corporation, United States Steel Corporation, and Weirton Steel Corporation. This database is believed to have never previously been systematically organized. Samples were grouped based on sampling times to determine whether they should most appropriately be compared to the OSHA short-term excursion limit (EL) or the 8-hr time-weighted average (TWA) permissible exposure limit (PEL). Sampling times of 30 min or less were considered short-term samples, and samples of 180 min or greater were considered representative workday samples. Samples that did not fit into either category, with sampling times between 31 and 179 min, were considered task samples. Overall, the data indicated that the airborne concentrations were quite low in 1989 and they continued to be low through the study period which ended in 1997. Only seven out of 286 (approximately 2.5%) short-term or representative workday samples were in exceedance of the current OSHA OELs that were implemented in 1994 (short-term samples being compared to the 1 f/cc EL and representative workday samples being compared to the 0.1 f/cc 8-hr TWA PEL). Consistent with prior data, analysis of this dataset supports the view that materials containing asbestos were not used in many applications in the steel industry, and measured airborne concentrations of asbestos were almost always below the occupational exposure limits (OELs) in the post-OSHA era (1972-2000).

Identification of critical industry skills in an industrial hygiene graduate training program.

Graduates of industrial hygiene training (IH) programs must be able to meet continuously evolving health and safety needs in a wide variety of occupational settings. Therefore, academic IH graduate programs must regularly evaluate their curricula and solicit input from industry professionals to make curricular changes that will better prepare their students for professional roles in industry. The purpose of this study was to identify the training gaps that existed between industry needs and the current curriculum for a United States-accredited IH graduate training program. The research team facilitated two group interviews with the IH program advisory board, collected alumni survey data, and performed a qualitative analysis to identify skills gaps/needs for the IH Program graduates. The research team identified 3 themes from participant interviews and alumni surveys (technical, applied, and essential skills) and selected several skills within each theme that interview participants thought were necessary proficiencies for junior IH professionals. The skills identified in the qualitative interview and survey data can be incorporated into the curriculum to improve the training of IH graduate students. Additionally, by using qualitative analysis, the researchers uncovered essential skills previously unidentified in IH needs assessments, providing valuable information for all IH graduate programs.

Visualizing the NIOSH Pocket Guide: Open-source web application for accessing and exploring the NIOSH Pocket Guide to Chemical Hazards.

The NIOSH Pocket Guide to Chemical Hazards is a trusted resource that displays key information for a collection of chemicals commonly encountered in the workplace. Entries contain chemical structures-occupational exposure limit information ranging from limits based on full-shift time-weighted averages to acute limits such as short-term exposure limits and immediately dangerous to life or health values, as well as a variety of other data such as chemical-physical properties and symptoms of exposure. The NIOSH Pocket Guide (NPG) is available as a printed, hardcopy book, a PDF version, an electronic database, and a downloadable application for mobile phones. All formats of the NIOSH Pocket Guide allow users to access the data for each chemical separately, however, the guide does not support data analytics or visualization across chemicals. This project reformatted existing data in the NPG to make it searchable and compatible with exploration and analysis using a web application. The resulting application allows users to investigate the relationships between occupational exposure limits, the range and distribution of occupational exposure limits, and the specialized sorting of chemicals by health endpoint or to summarize information of particular interest. These tasks would have previously required manual extraction of the data and analysis. The usability of this application was evaluated among industrial hygienists and researchers and while the existing application seems most relevant to researchers, the open-source code and data are amenable to modification by users to increase customization.

A control banding method for chemical risk assessment in occupational settings in France.

Background: This study describes a method whose aim is to help companies assess the chemical occupational risks related to labeled products and industrial chemical emissions. The method is intended to be used by industrial hygienists at the scale of one company. Both inhalation and cutaneous exposure routes are taken into account. Methods: The method relies on a control-banding scheme. A work situation is described by exposure parameters such as the process or the local exhaust ventilation and by the hazard of the product. Each possible value of the parameters is associated with a "band," which is associated with an integer value. The multiplication of these values results in a score, which represents a priority for intervention. The higher the score, the more the situation warrants investigation for implementing prevention measures, such as chemical substitution and the addition of local exhaust ventilation. To simplify communication, the priority is associated with a colored priority band: red for "very high priority," orange for "high priority," and green for "moderate priority." The priority bands are computed for all work situations performed in a company. Results: An example of the use of this method is described in a French façade insulation company. Conclusion: A tool named Seirich was developed to implement this method and promote good practices for helping industrial hygienists in the prioritization of interventions for reducing chemical risk in France.

Occupational exposure to asbestos in the steel industry (1972-2006).

BACKGROUND: Historically, the use of asbestos in steelmaking has been limited to a few applications. Due to its physical and chemical properties, asbestos was not necessary or suitable for most purposes in a steel mill. The few applications where asbestos were used (i.e., certain gaskets, brakes, protective cloth, refractory materials, insulation materials, and hot top products) were replaced by alternative materials as they became available. OBJECTIVE: We discuss historical uses of asbestos in steel manufacturing and the associated airborne asbestos concentrations collected at sixteen U. S. Steel facilities between 1972 and 2006. METHODS: A total of 495 personal airborne asbestos samples from the U. S. Steel industrial hygiene records were analyzed across four time periods corresponding to changes in the OSHA permissible exposure limit (PEL) for asbestos. 68% of the samples (n = 337) were considered representative of an employee's workday. The remaining samples (n = 158) represented task samples. Samples were grouped by facility, department, and job category within the four time periods. RESULTS: The average fiber concentrations measured for each facility and department over time were below the contemporaneous OSHA PEL. The mean representative workday asbestos air concentration from 1972 and 1975 was 1.09 f/cc. The mean representative workday concentration decreased to 0.13 f/cc between 1976 and 1985, then decreased again to 0.02 f/cc between 1986 and 1993 and 0.03 f/cc between 1994 and 2006. For task samples, the mean air concentration from 1972 to 1975 was 3.29 f/cc. The mean task sample concentration decreased to 0.48 f/cc between 1976 and 1985, then decreased again to 0.01 f/cc between 1986 and 1993 and 0.03 f/cc between 1994 and 2006. Only eleven out of the 495 samples (2.2%), for both task and representative workday samples, were in exceedance of the contemporaneous PEL(as an 8-hour TWA), ten of which occurred prior to 1978. Eight of these eleven PEL exceeding samples were task samples. Of the remaining three representative workday samples, two had unknown sampling times. IMPACT: This paper presents an analysis of all the available personal sampling data for airborne asbestos across 16 facilities of the U. S. Steel Corporation between 1972 and 2006. This dataset has previously never been publicly shared or analyzed. It represents one of the more complete industrial hygiene datasets from a corporation to be presented in a scientific journal and, due to the similarities in the processes at each mill, it should reflect analogous exposures throughout the steelmaking industry in the United States. One of the benefits of presenting these data is that it also provides insight into where asbestos-containing materials (ACMs) were used in the steel making process. This is just one example of a large firm that released information that had previously remained in file cabinets for decades. We believe that another benefit of publishing this paper is that it may encourage the largest firms in industry to assemble and analyze their industrial hygiene data to benefit the occupational hygiene, medical, and epidemiology communities. This can support future epidemiology studies and improve the design of future industrial hygiene programs.

AirPen: A Wearable Monitor for Characterizing Exposures to Particulate Matter and Volatile Organic Compounds.

Exposure to air pollution is a leading risk factor for disease and premature death, but technologies for assessing personal exposure to particulate and gaseous air pollutants, including the timing and location of such exposures, are limited. We developed a small, quiet, wearable monitor, called the AirPen, to quantify personal exposures to fine particulate matter (PM2.5) and volatile organic compounds (VOCs). The AirPen combines physical sample collection (PM onto a filter and VOCs onto a sorbent tube) with a suite of low-cost sensors (for PM, VOCs, temperature, pressure, humidity, light intensity, location, and motion). We validated the AirPen against conventional personal sampling equipment in the laboratory and then conducted a field study to measure at-work and away-from-work exposures to PM2.5 and VOCs among employees at an agricultural facility in Colorado, USA. The resultant sampling and sensor data indicated that personal exposures to benzene, toluene, ethylbenzene, and xylenes were dominated by a specific workplace location. These results illustrate how the AirPen can be used to advance our understanding of personal exposure to air pollution as a function of time, location, source, and activity, even in the absence of detailed activity diary data.

Strategies for refinement of occupational inhalation exposure evaluation in the EPA TSCA risk evaluation process.

The focus on occupational exposures in the first published risk evaluations of existing chemicals by the Environmental Protection Agency (EPA) under the amended Toxic Substances Control Act (TSCA) puts a welcome spotlight on protecting the health of workers in the United States. Because new, fit-for-purpose occupational exposure assessment methodologies were developed by EPA, the objective of this analysis was to evaluate these methodologies in light of other existing occupational risk assessment frameworks. We focused our analysis on three chlorinated chemicals (methylene chloride, carbon tetrachloride, perchloroethylene). The EPA's methods were evaluated relative to peer-reviewed and professional organizations' guidelines for conducting site- and facility-based exposure assessment. Analyses of several key phases in the EPA approach were conducted to evaluate the effect of alternative approaches on exposure estimates. The revised exposure estimates using these alternative approaches yielded substantially different exposure estimates from those in the TSCA risk evaluations for these chemicals. The results also demonstrated the importance of utilizing a tiered approach to exposure estimation that includes collecting qualitative data, defining similar exposure groups, and integrating well-parameterized models with empirical data. These approaches aid in preventing mischaracterization of exposures and generating exposure estimates representative of current industrial practices. Collaboration among industry, EPA, and other government agencies to develop a harmonized approach to exposure assessment would improve the methodological rigor of, and increase stakeholder confidence in, the results of TSCA risk evaluations.

Development of an interprofessional task-based learning program in the field of occupational health: a content validity study.

OBJECTIVE: One of the duties of the educational system is to provide situations in which students learn the tasks corresponding to their future careers in an interprofessional team. This study was designed to develop an interprofessional task-based training program. METHODS: This was a curriculum development study conducted by content validity methodology in two stages: 1) 'framework development' which resulted in the creation of the framework items; and 2) 'evaluation of the framework' (judgment and quantification). The first stage consisted of task identification, generation of sub-tasks, and assimilation of items into a usable format. The second stage consisted of the judgment -quantification of the content validity of items and the framework. After that, the framework of the tasks of the occupational health team was finalized in the expert panel. After explaining the tasks, a matrix for task-expected roles in the occupational health team and a matrix for task-required skills to perform each task were developed. The next step determined the appropriate teaching and assessment methods for each task. Finally, an expert panel reviewed and approved the components of the interprofessional task-based training program. RESULTS: Integrating the interprofessional education strategy with task-based learning was considered innovative in occupational health team training. In the development stage, 48 items were extracted, and then 35 tasks were generated in the step of identification of tasks. In the second step, 174 sub-tasks were developed. The tasks and sub-tasks were categorized into seven areas. After the stage of evaluation of the framework, 33 tasks were categorized into seven main areas, including "assessment and identification of workplace hazards" (n = 10), "control of occupational hazards" (n = 4), "determining the appropriate job position for each person" (n = 3), "occupational health examinations" (n = 6), "management of occupational/work-related diseases" (n = 5), "inter-organizational and inter-disciplinary relations, and legal judgment" (n = 3) and "education and scholarship in occupational health services" (n = 2). CONCLUSION: The results of the present study can be used in developing the use of the interprofessional strategy and task-based training as two appropriate strategies for the purposeful development of learners' abilities in the fields involved in providing occupational health services in their future careers.

[A system for collecting historical professional exposures in the workplace in Piedmont (ESP ALP).] / Un sistema per la catalogazione delle esposizioni storiche professionali negli ambienti di lavoro in Piemonte (ESP ALP).

SUMMARY: Background. ARPA Piemonte carries out occupational exposure measurements of chemical agents in workplace environment to support the Occupatonal Health and Safety Units of Local Health Boards for the assessment of the exposure level of dangerous chemical. Data are reported in internal documents, but are not available for other purposes. Objectives. Organize the occupational exposure measures collected by ARPA Piemonte, in order to facilitate their availability, in accordance with the indications of the European Foundation for the Improvement of Living and Working Conditions. Methods. An application in a relational database environment was defined and developed to collect and structure information relating to companies, interventions, tasks and / or monitored sampling points, samples and measurements performed. Results. Data on chemical exposure related to interventions carried out by ARPA Piemonte in the period from 2005 to part of 2020 have been collected in the ESP ALP application. ESP ALP contains information about 161 companies, 193 interventions, 815 sampling points, 3.490 samples and 18.576 measurements and information on companies obtained from the 2011 Census of Economic Activities and the archives of the National Institute for Insurance against Accidents at Work (INAIL). Discussion. We verified the feasibility of retrieving and organizing the information collected in past years in an integrated environment that facilitates its processing and use. Finally, we confirm the usefulness of collaboration between multidisciplinary professionals.

Assessment of Workplace Hygiene among Contractual Workers in the Steel and Power Industry of Odisha, India.

Background: Workplace hygiene is vital in controlling infectious diseases in industries. The factors like unhealthy environment, unhygienic workplace, and contact between healthy and disease-affected employees cause industrial hazards in workplaces. Objectives: This study assessed various components of workplace hygiene among industrial workers. Materials and Methods: A quantitative survey has been conducted in a steel, and power industry limited in Odisha. The study surveyed 425 male contractual workers for primary data on workplace hygiene. Probability proportion to sample technique adopted for justification of the sample. The univariate and bivariate analysis models have been done according to the study's objective. Results: Nearly 92% of respondents reported proper use of washing facilities, and 97% used toilet and urinal appropriately. One-fourth of respondents use personal disinfected clothing, and 92.2% have access to safe drinking water. The factors such as education, technical education, and occupation are significantly associated with respondents' use of washing facilities, dining hall, personal protective clothing, safe drinking water, proper cleaning, and sanitation at the workplace. Conclusion: Workplace hygiene strengthens the safety measures at the workplace and reduces the incidences of occupational hazards.

Intra-workday fluctuations of airborne contaminant concentration and the time-weighted average.

Air contaminant concentrations vary between and within workdays and are often measured across a workday by passing a known air volume through a collection device. Laboratory analysis determines the contaminant mass trapped, providing a time-weighted average air concentration (CTWA). This approach was driven by the best technologies available as exposure measurement processes developed and accuracy and measurement precision were sought. However, all integrated concentration•time (C•t) values determining CTWA are equally weighted in assessing exposures, intra-workday concentration variability is unknown, and results are available days later. At times inappropriately, an occupational exposure limit (OEL) expressed as a CTWA also requires equal weighting of all C•t values across an exposure period following concepts of Haber's law. Continuous monitoring (real-time detection) informs both the CTWA and the variability of C during sampling, which are needed for stressors where a ceiling or peak OEL exists, for dangerous exposures to permanent gas-type contaminants, and for immediately dangerous to life or health (IDLH) conditions. Selective and accurate real-time detection instruments are not available for all air contaminants, but exposure magnitude information may be provided. The large amounts of data from continuous monitoring and the ability to correlate exposure maxima to specific tasks are also important. An exposure assessment role exists for selective and nonselective monitors, and in some cases, similar accuracy and precision are provided compared to laboratory analyses. Continuous monitoring may be of value when the alternative is the collection of a few CTWA data points. Digitized personal monitor data can support the automation of some exposure control decisions or allow such decisions to be made by people in near real-time. The emerging Internet of Things (IoT) offers opportunities to integrate digital exposure data into decision-making to increase both efficiency and safety. The perceived and real uncertainty associated with real-time exposure assessments may be lessened with work to rule out the presence of know interferents and confirm the presence of target analytes.

Comparison of Two Entertainment Industry COVID-19 Programs.

This article follows two entertainment industry COVID-19 worker safety programs from inception through implementation. The first plan was developed by the four major film industry unions in concert with their expert consultants. The second plan for live theater was initiated by the Broadway League, a national trade association for the theater owners, operators, producers, presenters, and general managers in North American cities and their suppliers of goods and services. The efficacy of the plans to provide cast and crew with proper industrial hygiene measures such as ventilation and protective masks is compared by the author.

Mujeres e higiene industrial en el México posrevolucionario: el informe de Juan de Beraza sobre "La Perfeccionada" (25 de octubre, 1919) / Women and industrial hygiene in post-revolutionary Mexico: Juan de Beraza's report on "La Perfeccionada" (October 25, 1919)

Resumen En octubre de 1919, en medio de la construcción de las instituciones posrevolucionarias de protección de la salud en México, Juan de Beraza, oficial ayudante de la Secretaria de Industria, Comercio y Trabajo, redactó un documento sobre las condiciones de 479 obreras de una fábrica de la capital. El informe presentó un resumen de los problemas de higiene y de acoso sexual que las mujeres experimentaron en los espacios laborales. El documento ofrece información relevante para la historia de las mujeres dentro del "mundo del trabajo" en las primeras décadas del siglo XX. Se publica una transcripción del informe precedida de una presentación del mismo.

Abstract In October 1919, during the construction of post-revolutionary health protection institutions in Mexico, Juan de Beraza, an office assistant to the Secretary of Industry, Commerce, and Labor, wrote a document about the conditions of 479 women workers in a factory in the capital. The report had a summary of hygiene and sexual harassment problems that women experienced in their workplaces. The document offers relevant information about the history of women in the "world of work" in the first decades of the twentieth century. A transcript of the report is published, preceded by a presentation of the report.

SARS-CoV-2 genomic surveillance as an evidence-based infection control approach in an offshore petroleum employee population.

BACKGROUND: Industrial hygienists (IH) in the oil and gas business instituted an extraordinary number of safety protocols to limit spread of SARS-CoV-2 onto offshore platforms in the Gulf of Mexico. We used genomic surveillance to provide actionable information concerning the efficacy of their efforts. METHODS: Over 6 months, employees at a single company were serology and PCR tested during a 1-5 day predeployment quarantine and when postdeployment symptoms were reported. From each positive test (n = 49), SARS-CoV-2 genomes were sequenced. Phylogenetic analysis was used to investigate the epidemiology of transmissions. RESULTS: Genomic surveillance confirmed 2 viral strains were infecting 18 offshore workers. Genomic data combined with epidemiological data suggested that a change in quarantine protocols contributed to these outbreaks. A pre-deployment outbreak involved a WHO variant of interest (Theta) that had infected 4 international workers. Two additional predeployment clusters of infections were identified. CONCLUSIONS: Our findings support that IH quarantine/testing protocols limited viral transmissions, halted offshore outbreaks, and stopped the spread of a variant of interest. The study demonstrates how genomic data can be used to understand viral transmission dynamics in employee populations and evaluate safety protocols in the offshore oil and gas industry.

A real-time gas monitoring system based on ion mobility spectrometry for workplace environmental measurements.

A volatile organic compounds (VOC) gas monitor was developed using an ion mobility spectrometer (IMS). It was designed for real-time monitoring in work environments, where gas chromatography/mass spectrometry (GC/MS) does not perform well. To evaluate the identification capability, response time, and quantitative accuracy of this device, experiments were conducted using methyl ethyl ketone. This is widely used in many factories, and its short-term exposure limit (STEL) has been set by the American Conference of Governmental Industrial Hygienists. Because the ionizable amount of methyl ethyl ketone has already been exceeded in STEL value of 300 ppm which belongs to the measurement range of interest in this study, this study estimated the peak shift amount rather than the peak intensity. Calibration curves with high accuracy were obtained in a range including 300 ppm which is the STEL of methyl ethyl ketone. The results of the experiment suggest that the device can be used for monitoring chemical substances in a work environment.

Exposure assessment of nanotitanium oxide powder handling using real-time size-selective particle number concentration measurements and X-ray fluorescence spectrometry -The possibility of exposure to nonagglomerated nanomaterials during the handling of nanomaterial fine powders.

In this study, airborne particles were collected using filters, and the particle number concentrations were measured in two nanotitanium dioxide (nanoTiO2)-manufacturing plants. Real-time particle size measurements were performed using both optical and scanning mobility particle sizer and X-ray fluorescence spectrometry (XRF). The respirable particles collected using filters were used to analyze Ti concentrations in the workplace air of two factories engaged in nanoTiO2 powder bagging processes. The XRF analysis revealed sufficient sensitivity to measure 0.03 mg/m3, which is 1/10 the concentration of the recommended occupational exposure limit of nanoTiO2 in both stationary sampling and personal exposure sampling settings. In a factory where outside air was directly introduced, micron-sized aggregated particles were generated because of factory operations; however, nanosized and submicron-sized particles were not observed owing to high background concentrations of incidental nanoparticles. Alternatively, in another factory where particles from the outside air were removed using a high-efficiency particulate air filter, work-related nanoparticles were released. The findings of this study suggest that in nanoparticle powder handling processes, a nanoparticle exposure risk exists in the form of nonagglomerated state in nanoparticle powder handling processes.

Exposure analysis of benzene in workplace control room A and B PT X.

OBJECTIVE: The control room A and B employees are a high risk of benzene exposure, because they work close to the waste pit which is a source of benzene. This study is to analyze the magnitude of the health risk of benzene exposure to all employees. METHODS: The data of this study were obtained from interviews and the results of environmental quality of PT X. Data were analyzed using Environmental Health Risk Analysis (EHRA) method which compared with RfC for non-carcinogenic effects and CSF for carcinogenic effects. RESULTS: The results of individual calculations for the non-carcinogenic and carcinogenic effect of benzene are at a dangerous level in both real time and lifetime exposure. CONCLUSIONS: In the calculation of carcinogenic and non-carcinogenic risk exposure in real time, half the populations are at risk of being affected and in lifetime the entire populations are at risk of being exposed to these effects.

Exposure analysis of lead (Pb) and chromium (Cr) in workplace workshop PT. X.

OBJECTIVE: The workshop (pipe repair place) owned by PT. X is potential for heavy metal exposure which can exceed the quality standards. This study is to identify and analyze the risk of heavy metal exposure from the production process and compare it with the quality standards for the workplace that have been set by the government. METHODS: This research is a quantitative study using the method of environmental health risk analysis (EHRA). RESULT: The concentration of risk agents that could cause adverse health effects of non-carcinogenic due to lead exposure was 15 workers both realtime and lifetime, chromium exposure was 6 workers in realtime and 15 workers for lifetime. While the results of carcinogenic effects due to lead exposure were 1 worker for lifetime and chromium was 15 workers both realtime and lifetime. CONCLUSION: Efforts to control heavy metals can be carried out through technical engineering, administrative control, and personal protective equipment.