RESUMO
Lanthanum-silicate substituted apatite with equal concentrations of the substituents in the range of 0.2-6.0â¯mol were produced by a fast method - mechanochemical synthesis. This method makes it possible to synthesize a nanosized single-phase product by activating reaction mixtures containing CaHPO4, CaO, La(OH)3 and SiO2·H2O for 25-30â¯min in AGO-2 and AGO-3 planetary mills. The structure of the apatites was investigated by the FTIR and XRD methods. It was found that the synthesized samples with substituent concentrations up to 2â¯mol are substituted oxy-hydroxyapatites, at higher concentrations, they are substituted oxyapatites. The mechanochemically synthesized apatite with a substituent concentration of 0.5â¯mol was used for depositing biocoatings on titanium substrates by the micro-arc oxidation method. The structure of the coatings is mainly amorphous. In vitro biological tests demonstrated high biocompatibility of the coatings and the absence of cytotoxic action on mesenchymal stem cells.