Precooked state based on protein denaturation kinetics impacts moisture status, protein oxidation and texture of prepared chicken breast.

The quality of meat in prepared dishes deteriorates due to excessive protein denaturation resulting from precooking, freezing, and recooking. This study aimed to link the precooked state with chicken breast's recooked quality. Cooked Value (CV), based on protein denaturation kinetics, was established to indicate the doneness of meat during pre-heating. The effects of CVs after pre-heating on recooked qualities were investigated compared to fully pre-heated samples (control). Mild pre-heating reduced water migration and loss. While full pre-heating inhibited protein oxidation during freezing, intense oxidation during pre-heating led to higher oxidation levels. Surface hydrophobicity analysis revealed that mild pre-heating suppressed aggregation during recooking. These factors contributed to a better texture and microstructure of prepared meat with mild pre-heating. Finally, a potential mechanism of how pre-heating affects final qualities was depicted. This study underlines the need for finely controlling the industrial precooking process to regulate the quality of prepared meat.

Developmental differences in canonical cortical networks: Insights from microstructure-informed tractography.

In response to a growing interest in refining brain connectivity assessments, this study focuses on integrating white matter fiber-specific microstructural properties into structural connectomes. Spanning ages 8-19 years in a developmental sample, it explores age-related patterns of microstructure-informed network properties at both local and global scales. First, the diffusion-weighted signal fraction associated with each tractography-reconstructed streamline was constructed. Subsequently, the convex optimization modeling for microstructure-informed tractography (COMMIT) approach was employed to generate microstructure-informed connectomes from diffusion MRI data. To complete the investigation, network characteristics within eight functionally defined networks (visual, somatomotor, dorsal attention, ventral attention, limbic, fronto-parietal, default mode, and subcortical networks) were evaluated. The findings underscore a consistent increase in global efficiency across child and adolescent development within the visual, somatomotor, and default mode networks (p < 0.005). Additionally, mean strength exhibits an upward trend in the somatomotor and visual networks (p < 0.001). Notably, nodes within the dorsal and ventral visual pathways manifest substantial age-dependent changes in local efficiency, aligning with existing evidence of extended maturation in these pathways. The outcomes strongly support the notion of a prolonged developmental trajectory for visual association cortices. This study contributes valuable insights into the nuanced dynamics of microstructure-informed brain connectivity throughout different developmental stages.

There is a growing interest in incorporating biologically relevant white matter properties into the analysis of brain networks to obtain a more quantitative assessment of brain connectivity. In a developmental sample aged 8­19 years, we studied age-related patterns of local and global network properties. We generated microstructure-informed connectomes using diffusion MRI data, and computed network characteristics in eight functionally defined networks (visual, somatomotor, dorsal attention, ventral attention, limbic, fronto-parietal, default mode, and subcortical networks). The findings reveal that throughout child and adolescent development, global efficiency increases in the visual, somatomotor, and default mode networks, and mean strength increases in the somatomotor and visual networks. Nodes belonging to the dorsal and ventral visual pathways demonstrate the largest age-dependence in local efficiency, supporting previous evidence of protracted maturation of dorsal and ventral visual pathways. The results provide compelling evidence that there is a prolonged development of visual association cortices.

Microstructure and Mechanical Properties of NiTi Alloy Prepared by Double-Wire + Arc Additive Manufacturing Plus In Situ Heat Treatment.

In this study, NiTi shape memory alloy was prepared by double-wire + arc additive manufacturing plus in situ heat treatment using TA1 and ER-Ni welding wires as the raw materials. The results show that the microstructural evolution from the bottom to top is NiTi2 + NiTi → NiTi + Ni3Ti + Ni4Ti3 → NiTi + Ni4Ti3 + Ni3Ti2 + Ni3Ti + α-Ti. Complex thermal cycles led to the precipitation of Ni3Ti, which improves the hardness of the matrix (B2), and the average hardness value of the top region reaches 550.7 HV0.2. The fracture stress is 2075 ± 138.4 MPa and the fracture strain is 11.2 ± 1.27%. The sample shows 7.02% residual strain and 5.87% reversible strain after 15 cycles, and the stress hysteresis decreases with an increase in cyclic strain.

Is Low Polydispersity Always Beneficial? Exploring the Impact of Size Polydispersity on the Microstructure and Rheological Properties of Graphene Oxide.

Graphene oxide (GO) is a promising material widely utilized in advanced materials engineering, such as in the development of soft robotics, sensors, and flexible devices. Considering that GOs are often processed using solution-based methods, a comprehensive understanding of the fundamental characteristics of GO in dispersion states becomes crucial given their significant influence on the ultimate properties of the device. GOs inherently exhibit polydispersity in solution, which plays a critical role in determining the mechanical behavior and flowability. However, research in the domain of 2D colloids concerning the effects of GO's polydispersity on its rheological properties and microstructure is relatively scant. Consequently, gaining a comprehensive understanding of how GO's polydispersity affects these critical aspects remains a pressing concern. In this study, we aim to investigate the dispersions and structure of GOs and clarify the effect of polydispersity on the rheological properties and yielding behavior. Using a rheometer, polarized optical microscopy, and small-angle X-ray scattering, we found that higher polydispersity in the same average size leads to overall improved rheological properties and higher flowability during yielding. Thus, our study can be beneficial in the employment of polydispersity in the processing of GO such as 3D printing and fiber spinning.

Effect of grinding method and extent of pelleting of broiler diets on performance, feeding behaviour and digestive tract functionality.

1. An experiment was carried out examine if a heterogeneous diet consisting of pellets and coarse cereal particles would result in a similar feed intake to pelleted-only diets. It considered whether coarser particles entering the gizzard would encourage the development of the gizzard and thus improve digestive tract functionality. Maize and wheat were hammer milled through a 3 mm screen after coarse grinding using either one of the two screens with a novel pattern. Three pellet-only diets were produced based on three grinding sizes. Additionally, four diets were produced by separating coarse cereal particles from moderately coarse particles by sieving either once or twice, pelleting the remainder and finally mixing these into a complete heterogeneous diet.2. No difference in performance between birds fed the three pelleted-only diets was observed. However, heterogeneous diets resulted in a lower feed intake (FI) and weight gain (WG) than pelleted-only diets (p < 0.05). The dietary treatments neither affected the feed conversion ratio nor ileal digestibility of starch and protein (p > 0.05). As expected, feeding a heterogeneous diets increased (p < 0.05) the relative weight of the gizzard and its contents. Approximately 50% of the particles in the small intestine were between 0.15 mm and 0.36 mm in diameter, with more fine particles observed when the pelleted-only diets containing coarsely ground cereals were fed, confirming the capacity of the gizzard to finely grind feed.3. Sieving of the diet remaining in the feeder during 4 h of feeding two of the heterogeneous diets showed that the particles > 2.8 mm disappeared first (p < 0.05), showing the birds' preference for larger particles when offered heterogeneous diets. Although the birds were able to handle the coarse microstructure of the diets without any negative effects, the reduced performance in the case of heterogeneous diets might have been related to feed intake issues and particle selection, resulting in an imbalance in nutrient intake.

A study on the bond strength and durability characteristics of high-performance concrete modified with toughened glass waste aggregates.

Amidst rising natural aggregate consumption, recycling dumped waste for structural concrete effectively addresses resource scarcity and environmental contamination. Nevertheless, the adoption of toughened glass waste aggregate (TGWA) in construction remains relatively limited. This study explores the potential use of toughened glass waste (TGW) as a substitute for natural coarse aggregate (NCA) in high-performance concrete (HPC). This paper assesses the bond strength of deformed bars embedded in toughened glass waste high-performance concrete (TGW-HPC), considering different steel reinforcement diameters (8 mm and 12 mm) and various levels of TGW replacement (ranging from 0 % to 100 %). Various durability properties, including water absorption, water permeability, chloride ion penetration, and acid attack were examined. The study also investigated the microstructural characteristics of acid attacked specimens using techniques such as XRD, FTIR, and FESEM. Several important parameters, such as chloride diffusivity (D), hydraulic diffusivity (D (θ)), and permeability coefficients (K), were derived from the experimental data. The study found TGW50-HPC resulted in the highest bond strength, about 13.1 % more than the control mix. However, TGW100-HPC bond strength decreased by 17.51 % compared to the control mix. Notably, TGW100-HPC exhibited superior durability properties and showed the lowest coefficient of permeability, indicating reduced chloride ion, and water molecule transport through the interconnected pore structure. At 90 days, the TGW100-HPC mixture exhibited a strength reduction of 42.29 %, which closely resembled the 41.20 % reduction observed at 56 days. The formation of thenardite and basanite mitigate damage to the interfacial transition zone (ITZ) led to fewer micro-cracks and reduced acid ingress through the matrix. Incorporating TGWA in engineering projects can lead to cost savings through reduced raw material expenses and disposal fees, resulting in significant economic benefits and social well-being.

Radio Frequency Vacuum Drying Study on the Drying Characteristics and Quality of Cistanche Slices and Analysis of Heating Uniformity.

To fully leverage the advantages of both hot air drying and radio frequency vacuum drying, a segmented combination drying technique was applied to post-harvest Cistanche. This new drying method involves using hot air drying in the initial stage to remove the majority of free water, followed by radio frequency vacuum drying in the later stage to remove the remaining small amount of free water and bound water. During the radio frequency vacuum drying (RFV) phase, the effects of temperature (45, 55, and 65 °C), vacuum pressure (0.020, 0.030, and 0.040 MPa), plate spacing (65, 75, and 85 mm), and slice thickness (4, 5, and 6 mm) on the drying characteristics, quality, and microstructure of Cistanche slices were investigated. Additionally, infrared thermal imaging technology was used to examine the surface temperature distribution of the material during the drying process. The results showed that compared to radio frequency vacuum drying alone, the hot air-radio frequency combined drying significantly shortened the drying time. Under conditions of lower vacuum pressure (0.020 MPa), plate spacing (65 mm), and higher temperature (65 °C), the drying time was reduced and the drying rate increased. Infrared thermal imaging revealed that in the early stages of hot air-radio frequency vacuum combined drying, the center temperature of Cistanche was higher than the edge temperature. As drying progressed, the internal moisture of the material diffused from the inside out, resulting in higher edge temperatures compared to the center and the formation of overheating zones. Compared to natural air drying, the hot air-radio frequency vacuum combined drying effectively preserved the content of active components such as polysaccharides (275.56 mg/g), total phenols (38.62 mg/g), total flavonoids (70.35 mg/g), phenylethanoid glycosides, and iridoids. Scanning electron microscopy observed that this combined drying method reduced surface collapse and cracking of the material. This study provides theoretical references for future drying processes of Cistanche.

Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy.

BACKGROUND: Bisphosphonate (BP) can treat osteoporosis and prevent osteoporotic fractures in clinical. However, the effect of BP on microstructure and mechanical properties of cortical and trabecular bone has been taken little attention, separately. METHODS: In this study, BP was used to intervene in ovariectomized female SD rats. The femoral micro-CT images were used to measure the structural parameters and reconstruct the 3D models in volume of interest. The structural parameters of cortical and trabecular bone were measured, and the mechanical properties were predicted using micro-finite element analysis. RESULTS: There was almost no significant difference in the morphological structure parameters and mechanical properties of cortical bone between normal, ovariectomized (sham-OVX) and BP intervention groups. However, BP could significantly improve bone volume fraction (BV/TV) and trabecular separation (Tb.SP) in inter-femoral condyles (IT) (sham-OVX vs. BP, p < 0.001), and had no significant effect on BV/TV in medial and lateral femoral condyles (MT, LT). Similarly, BPs could significantly affect the effective modulus in IT (sham-OVX vs. BP, p < 0.001), and had no significant difference in MT and LT. In addition, the structural parameters and effective modulus showed a good linear correlation. CONCLUSION: In a short time, the effects of BP intervention and osteoporosis on cortical bone were not obvious. The effects of BP on trabecular bone in non-main weight-bearing area (IT) were valuable, while for osteoporosis, the main weight-bearing area (MT, LT) may improve the structural quality and mechanical strength of trabecular bone through exercise compensation.

Relationship between visual function and macular microstructure in highly myopic patients undergoing surgery for rhegmatogenous retinal detachment.

OBJECTIVE: To analyze the relationship between visual function and macular microstructure in highly myopic patients undergoing surgery for rhegmatogenous retinal detachment (RRD). METHODS: Fifty-eight highly myopic patients treated in the Baoding No. 1 Central Hospital between December 2021 and September 2023 were selected as the research participants for retrospective analysis. All patients were complicated with RRD and underwent retinal reattachment surgery at Baoding No. 1 Central Hospital after diagnosis. Best-corrected visual acuity (BCVA) examinations were performed before and 3 months after surgery, and visual field mean sensitivity (MS) and fixation stability (FS) were measured by microperimetry. Additionally, changes in postoperative macular microstructure and micro blood flow were determined by optical coherence tomography (OCT), and their correlations with visual function were analyzed. RESULTS: Patients showed reduced BCVA, MS, and FS after surgery (all P<0.05), with 70.69% of them presenting with macular microstructural changes, mainly ellipsoid zone disruption and external limiting membrane disruption. Patients with macular microstructural changes exhibited significantly decreased BCVA, MS, and FS than those without (all P<0.05). In terms of micro blood flow, the BCVA, FS, and MS of patients with macular microstructural changes were negatively correlated with the foveal avascular zone (FAZ) area but were positively related to FAZ morphological index, PSCP, and VSCP (all P<0.05). CONCLUSIONS: Changes in patients' visual function after surgery for RRD can be effectively evaluated by observing the macular ellipsoid, the integrity of the external limiting membrane, and the alterations in micro-blood flow, enabling the formulation of early and targeted interventions.

Effect of curing conditions on cement based self-compacting mortar produced with mortar waste aggregate.

Concrete and mortar wastes, which have a large volume and economic value among construction demolition wastes, are the most targeted demolition waste group to be recycled. An important area where construction demolition waste can be utilized is self-compacting mortar (SCM) systems. SCMs are innovative and economical systems designed to minimize the labor requirements that are difficult to meet in the production process. In this study, mortar waste aggregate (MWA) obtained by mechanical crushing and grinding was used in SCM elements by substituting different ratios (5-10-20-30-40 %) by mass to aggregate. In this way, it was aimed to evaluate both the sustainability of MWAs and the usability of MWAs in SCMs, which are considered as a new production technology. The fresh and hardened mortar tests performed in the study are presented comparatively. The physical (dry unit volume weight, porosity), durability (capillary water absorption) and mechanical properties (flexural tensile, compressive strength) of the hardened SCM elements are based on the determinations made at 3, 7 and 28 test days and according to different curing conditions (water curing, air curing and heat curing). In addition, X-ray Diffractometer (XRD) analysis was performed on specimens obtained from 0 %, 10 %, 20 % and 40 % MWA substituted specimens after heat curing (after 7 days water curing) and 28 days water curing. In the light of the data obtained, it is reported that SCM production with 10 % MWA substitution is feasible in terms of sustainability and engineering properties evaluated in this study.

The interaction between maize resistant starch III and Bifidobacterium adolescentis during in vitro fermentation.

As an alternative to traditional dietary fibers with prebiotic effects, the interaction between resistant starch III (RS3) and gut microbiota is worth exploring. In this study, the effects of RS3 on the proliferation of Bifidobacterium adolescentis (B. adolescentis) and their structural changes before and after fermentation were investigated. Autoclaved-debranched resistant starch (ADRS) demonstrated the best proliferative effect for B. adolescentis and the highest roughness (Ra = 21.90 nm; Rq = 16.00 nm). The rough surface of ADRS was the key for B. adolescentis proliferation. B. adolescentis produced an extracellular amylase to assist degradation and showed the highest activity in ADRS. Fermentation disrupted short-range ordered structure and reduced R1047 cm-1/1022 cm-1 by 20.74 % and R995 cm-1/1022 cm-1 by 30.85 %. The extracellular amylase was essential substance for ADRS degradation. These findings help optimize RS3 structure and promote the proliferation of intestinal probiotics.

Insights into particle dispersion and damage mechanisms in functionally graded metal matrix composites with random microstructure-based finite element model.

This study investigates the impact of Al 2 O 3 particle volume fraction and distribution on the deformation and damage of particle-reinforced metal matrix composites, particularly in the context of functionally graded metal matrix composites. In this study, a two-dimensional nonlinear random microstructure-based finite element modeling approach implemented in ABAQUS/Explicit with a Python-generated script to analyze the deformation and damage mechanisms in AA 6061 - T 6 / Al 2 O 3 composites. The plastic deformation and ductile cracking of the matrix are captured using the Gurson-Tvergaard-Needleman model, whereas particle fracture is modelled using the Johnson-Holmquist II model. Matrix-particle interface decohesion is simulated using the surface-based cohesive zone method. The findings reveal that functionally graded metal matrix composites exhibit higher hardness values ( HRB ) than traditional metal matrix composites. The results highlight the importance of functionally graded metal matrix composites. Functionally graded metal matrix composites with a Gaussian distribution and a particle volume fraction of 10% achieve HRB values comparable to particle-reinforced metal matrix composites with a particle volume fraction of 20%, with only a 2% difference in HRB . Thus, HRB can be improved significantly by employing a low particle volume fraction and incorporating a Gaussian distribution across the material thickness. Furthermore, functionally graded metal matrix composites with a Gaussian distribution exhibit higher HRB values and better agreement with experimental distribution functions when compared to those with a power-law distribution.

Advancements in Subchondral Bone Biomechanics: Insights from Computed Tomography and Micro-Computed Tomography Imaging in Equine Models.

PURPOSE OF REVIEW: This review synthesizes recent advancements in understanding subchondral bone (SCB) biomechanics using computed tomography (CT) and micro-computed tomography (micro-CT) imaging in large animal models, particularly horses. RECENT FINDINGS: Recent studies highlight the complexity of SCB biomechanics, revealing variability in density, microstructure, and biomechanical properties across the depth of SCB from the joint surface, as well as at different joint locations. Early SCB abnormalities have been identified as predictive markers for both osteoarthritis (OA) and stress fractures. The development of standing CT systems has improved the practicality and accuracy of live animal imaging, aiding early diagnosis of SCB pathologies. While imaging advancements have enhanced our understanding of SCB, further research is required to elucidate the underlying mechanisms of joint disease and articular surface failure. Combining imaging with mechanical testing, computational modelling, and artificial intelligence (AI) promises earlier detection and better management of joint disease. Future research should refine these modalities and integrate them into clinical practice to enhance joint health outcomes in veterinary and human medicine.

Unraveling the complexity of amorphous solid as direct ingredient for conventional oral solid dosage form: The story of Elagolix Sodium.

Conventional solid oral dosage form development is not typically challenged by reliance on an amorphous drug substance as a direct ingredient in the drug product, as this may result in product development hurdles arising from process design and scale-up, control of physical quality attributes, drug product processability and stability. Here, we present the Chemistry, Manufacturing and Controls development journey behind the successful commercialization of an amorphous drug substance, Elagolix Sodium, a first-in-class, orally active gonadotropin-releasing hormone antagonist. The reason behind the lack of crystalline state was assessed via Molecular Dynamics (MD) at the molecular and inter-molecular level, revealing barriers for nucleation due to prevalence of intra-molecular hydrogen bond, repulsive interactions between active pharmaceutical ingredient (API) molecules and strong solvation effects. To provide a foundational basis for the design of the API manufacturing process, we modeled the solvent-induced plasticization behavior experimentally and computationally via MD for insights into molecular mobility. In addition, we applied material science tetrahedron concepts to link API porosity to drug product tablet compressibility. Finally, we designed the API isolation process, incorporating computational fluid dynamics modeling in the design of an impinging jet mixer for precipitation and solvent-dependent glass transition relationships in the cake wash, blow-down and drying process, to enable the consistent manufacture of a porous, non-sintered amorphous API powder that is suitable for robust drug product manufacturing.

Gray matter based spatial statistics framework in the 1-month brain: insights into gray matter microstructure in infancy.

The neurodevelopmental epoch from fetal stages to early life embodies a critical window of peak growth and plasticity in which differences believed to be associated with many neurodevelopmental and psychiatric disorders first emerge. Obtaining a detailed understanding of the developmental trajectories of the cortical gray matter microstructure is necessary to characterize differential patterns of neurodevelopment that may subserve future intellectual, behavioral, and psychiatric challenges. The neurite orientation dispersion density imaging (NODDI) Gray-Matter Based Spatial Statistics (GBSS) framework leverages information from the NODDI model to enable sensitive characterization of the gray matter microstructure while limiting partial volume contamination and misregistration errors between images collected in different spaces. However, limited contrast of the underdeveloped brain poses challenges for implementing this framework with infant diffusion MRI (dMRI) data. In this work, we aim to examine the development of cortical microstructure in infants. We utilize the NODDI GBSS framework and propose refinements to the original framework that aim to improve the delineation and characterization of gray matter in the infant brain. Taking this approach, we cross-sectionally investigate age relationships in the developing gray matter microstructural organization in infants within the first month of life and reveal widespread relationships with the gray matter architecture.

Mechanical properties and microscopic characterization of waste perlite powder as supplementary cementitious material.

In this study, we conducted a comprehensive investigation on the influence of waste perlite powder (WPP) on the various properties of mortar and paste, including slurry performance, mechanical strength, hydration products, and microstructure. Additionally, we also aimed to uncover the underlying mechanism behind these effects. It was found that WPP reduced the workability and facilitated the setting process of cement-WPP pastes. WPP decreased the mechanical strength of mortar, but it exhibited significant strength enhancement during the subsequent stages. The incorporation of WPP worsened the water absorption behavior; however, this negative effect was mitigated as the curing age of the mortar was prolonged. The drying shrinkage cement-WPP binary system was significantly improved, with the prolongation of curing age. Moreover, WPP reduced the early heat release of the binary system, which may be beneficial for reducing the temperature gradient in mass concrete. It was confirmed that WPP accelerated the transformation from AFt to AFm, promoted the formation of C-A-S-H and optimized the pore structure of the system. It was confirmed that WPP was involved in the hydration reaction, which accelerated the transformation from AFt to AFm and promoted the formation of C-A-S-H. Such results suggested that the reuse of WPP in concrete production was technically feasible owing to its high pozzolanic reactivity.

Flow softening and recrystallization accompanied flow in AZ61 magnesium alloy during thermomechanical processing.

The present work deals with characterizing the recrystallization accompanied flow and high temperature softening behavior of an extruded AZ61 magnesium alloy. This was supported by conducting a set of hot compression tests at temperatures in the range of 250-450 °C under the strain rate ranging from 0.001 to 0.1s-1. The flow curves at all thermomechanical conditions indicated high fractional softening representing the domination of dynamic recrystallization mechanism. Through a new quantitative approach, "Arrhenius type model", "modified Avrami equations" and Poliak and Jonas method were simultaneously employed to investigate the kinetic of dynamic recrystallization. It was revealed that the strain required for the same amount of recrystallization fraction increased with decreasing deformation temperature, and at a specified temperature, the required strain increases with increasing strain rate. Interestingly, an anomaly was found at 400 °C under the strain rate of 0.001s-1, where the recrystallization kinetic was faster than that of what was recorded at 450 °C. This anomaly was discussed relying on the nanoprecipitation of γ-phase at the prior boundaries and sub-boundaries which prohibited the grain boundary migration and also the rotation and coalescence of adjacent sub-grains.

Lactic acid fermentation improves rehydration and emulsifying properties of spray-dried egg yolk powder.

In this study, we investigated the protein structures, powder characteristics, as well as rehydration and emulsifying properties of spray-dried egg yolk powder after short-time lactic acid fermentation (3.5 h). Results indicate that fermentation improved the rehydration and emulsifying properties of yolk powder. Limosilactobacillus reuteri-fermented yolk powder exhibited better wettability due to the porous structure of particles and higher hydrophilicity. Lacticaseibacillus rhamnosus-fermented yolk powder had an enhanced coefficient of stability due to its smaller particles and higher surface charge. The higher water solubility of fermented yolk powder samples is mainly attributed to their lower hydrophobicity and higher zeta potential. The enhanced emulsifying activity of fermented yolk powder samples is primarily related to their increased ß-turn structure and better solubility. Furthermore, fermentation treatment altered powder moisture content and bulk densities, while not affecting its flow behavior and thermal stability. This study provides an effective approach to improving the quality of yolk powder.

Corrigendum: A review of healthy and fibrotic myocardium microstructure modeling and corresponding intracardiac electrograms.

[This corrects the article DOI: 10.3389/fphys.2022.908069.].

Intelligent Song Recognition via a Hollow-Microstructure-Based, Ultrasensitive Artificial Eardrum.

Artificial ears with intelligence, which can sensitively detect sound-a variant of pressure-and generate consciousness and logical decision-making abilities, hold great promise to transform life. However, despite the emerging flexible sensors for sound detection, most success is limited to very simple phonemes, such as a couple of letters or words, probably due to the lack of device sensitivity and capability. Herein, the construction of ultrasensitive artificial eardrums enabling intelligent song recognition is reported. This strategy employs novel geometric engineering of sensing units in the soft microstructure array (to significantly reduce effective modulus) along with complex song recognition exploration leveraging machine learning algorithms. Unprecedented pressure sensitivity (6.9 × 103 kPa-1) is demonstrated in a sensor with a hollow pyramid architecture with porous slants. The integrated device exhibits unparalleled (exceeding by 1-2 orders of magnitude compared with reported benchmark samples) sound detection sensitivity, and can accurately identify 100% (for training set) and 97.7% (for test set) of a database of the segments from 77 songs varying in language, style, and singer. Overall, the results highlight the outstanding performance of the hollow-microstructure-based sensor, indicating its potential applications in human-machine interaction and wearable acoustical technologies.