1.
Biosens Bioelectron
; 168: 112575, 2020 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32892115
RESUMO
A photonic crystal surface mode imaging (PCSMi) technique is implemented for the simultaneous detection of antibody binding with specific antigens in arrays containing 96- and 384-spots. Like the surface plasmon resonance imaging (SPRi) technique, the presented approach is label-free and permits interrogating an analyte by hundreds of different ligands immobilized in small spots. The adsorption kinetics is recorded with a sub-picogram resolution at every spot simultaneously. Possible implementations of this technique for multiplexed and high-throughput biosensing are discussed.