Synthesis, spectral and antimicrobial studies of amino acid derivative Schiff base metal (Co, Mn, Cu, and Cd) complexes.

Amino acid derivative Schiff base was synthesized by reaction of leucine with salicyldehyde in basic medium. The Schiff base was used as a ligand which was reacted with Co, Mn, Cu and Cd metals in order to form the stable complexes. The synthesized ligand and metals complexes were characterized by using different spectroscopic tools i.e. FT-IR, Mass spectrometry and NMR. The percentages of different elements present in ligand molecule and complexes was confirmed by Elemental analyzer. All compounds including ligand and complexes were also engaged with different bacterial (Escheria coli, Staphylococcus aureus, Bacillus subbtilis) and fungal strains (Alternaria alternate, Aspergillus flavus and Aspergillus niger) in order to check the inhibitory action of titled compounds. The results showed that the metal complexes have greater antimicrobial activities than ligand.

Synthesis with spectral investigation of new ligand derived from pyrimidine with some metal complexes / 国际药学研究杂志

New ligand were synthesized by two steps in first steps were prepared chalcones compound from reacting of various carbonyl compounds (3-amino acetophenone with salicyldehyde,the second steps were closure of the ring by reacting(chalcones compound(AS) with thiouria, then reaction mixture was reflux for (8h) to produce Pyrimidine derivatives(AST) also prepared some complexes with Fe(II),Co(II), Ni(II),Cu(II),the ligand (AST)with its complexes were characterized by ((FT.IR, Uv-Vis, HNMR, Mass)–spectra,elemental analysis, melting point, molar conductivity).