Development of a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit: a retrospective analysis based on the MIMIC IV database.

PURPOSE: The present study aimed to develop a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit to facilitate risk stratification and treatment planning. METHODS: We used the MIMIC IV 2.0 (the Medical Information Mart for Intensive Care IV) to retrieve patients with secondary bone tumors as a study cohort. To evaluate the predictive ability of each characteristic on patient mortality, stepwise Cox regression was used to screen variables, and the selected variables were included in the final Cox proportional hazard model. Finally, the performance of the model was tested using the decision curve, calibration curve, and receiver operating characteristic (ROC) curve. RESULTS: A total of 1028 patients were enrolled after excluding cases with missing information. In the training cohort, albumin, APSIII (Acute Physiology Score III), chemotherapy, lactate, chloride, hepatic metastases, respiratory failure, SAPSII (Simplified Acute Physiology Score II), and total protein were identified as independent risk factors for patient death and then incorporated into the final model. The model showed good and robust prediction performance. CONCLUSION: We developed a nomogram prognostic model for patients with secondary bone tumors in the intensive care unit, which provides effective survival prediction information.

Classification of bone tumor cases admitted to the National Orthopedic Hospital

From Jan. 1, 1946 to Dec. 31 1962 we were able to collect 605 bone tumors. The lesions were group-into 3 major divisions, namely: (1) Primary Bone Tumors, (2) Secondary Bone Tumors and (3) Osseous Lesions simulating Bone Tumors. Under Primary Bone Tumors are included the benign and malignant conditions that originate from the bone tissue and from the different tissues found inside the bone. Secondary Bone Tumors are neoplasms that arise elsewhere and involve the bone. The osseous lesions simulating bone tumors consist of a heterogenous group. There were 410 primary bone tumors, 145 secondary bone tumors and 50 bone lesions simulating bone tumors. The most common primary bone tumor is osteogenic sarcoma followed by giant cell tumor and then by osteochondromaAmong the secondary bone tumors the most common metastatic tumor originates from the thyroid gland. This is followed, according to their order of frequency, by neoplasms arising from the lungs, breast, and kidneysThe characteristic features of the different primary bone tumors are briefly discussedTaking for granted that the yearly average admission of patients is 2,500 the total bone tumors and allied lesions listed above presents 1.51% of the total admissions during the last 16 years. (Summary)