Long-term sustainability of the water-agriculture-energy nexus in Brazil's MATOPIBA region: A case study using system dynamics.

The global demand for agricultural commodities has driven extensive land conversion to agriculture in Brazil, especially in the MATOPIBA region. This area encompasses the Rio Grande Basin, a major tributary of the São Francisco Basin that is known for expanding intensive irrigated agriculture and hydropower generation. However, recent data reveal declining precipitation and aquifer recharge, potentially exacerbating ongoing water and land conflicts. This study investigates the long-term sustainability of agricultural expansion amid the worsening water scarcity using a system dynamics model. Findings suggest that rising costs and decreasing profits due to irrigation water shortages may hinder the expansion of irrigated land. By 2040, the irrigation demand may remain partly unmet, while downstream flow and baseflow could decrease. Additionally, agricultural expansion will significantly raise energy demand, posing a developmental challenge. We suggest that ensuring the sustainability of the Rio Grande Basin depends on improved water management and exploring alternative energy sources to address existing constraints.

Tree nuts demand analysis using the LA-AIDS model: A case of the Indian economy paradox.

India is one of the world's largest producers of tree nuts, yet it paradoxically remains a net importer of these commodities. This study aims to analyze the demand for imported tree nuts in India, motivated by the need to understand the factors contributing to this imbalance. The primary objective is to calculate income elasticities and own- and cross-price elasticities for five categories of imported tree nuts using the linear approximate almost ideal demand system model. Data is sourced from monthly import records from the United Nations Comtrade database covering 2014 to 2022. The tree nuts considered are almonds, cashews, pistachios, walnuts, and hazelnuts. Key findings reveal all imported tree nuts are normal goods. Cashews exhibit income elasticity (1.2), indicating a significant demand increase with rising incomes, while other nuts show income inelasticity. Cashews are price-elastic (-1.3), while other nuts are price-inelastic. Compensated cross-price elasticities indicate notable substitution effects, particularly between almonds and cashews. The study recommends enhancing domestic cashew production to meet growing demand and developing targeted marketing strategies to address competitive dynamics within the tree nut market. These strategies aim to reduce India's dependency on imports and promote a balanced, sustainable domestic market.

Muscle oxygenation and pain in different types of temporomandibular disorders.

OBJECTIVES: Studies exploring variations in peripheral muscle oxygenation and pressure pain thresholds (PPT) of masticatory muscles in individuals with Temporomandibular Disorders (TMDs) are limited. The purpose of this study was to compare variations in peripheral oxygenation of the masseter muscle; PPT of the masseter and temporal muscles and correlate peripheral muscle oxygenation and PPT of the masseter muscle in individuals with different types of TMDs. MATERIALS AND METHODS: Cross-sectional study involving 116 participants classified into three groups: muscle group (MG, n = 32), joint group (JG, n = 30) and muscle-joint group (MJG, n = 54). Individuals aged 26.97 ± 6.93, 68.97% female, 31,03% males were included. All participants were evaluated using the Diagnostic Criteria for Temporomandibular Disorders, Near-infrared spectroscopy (NIRS) for peripheral muscle oxygenation and pressure algometer for PPT. RESULTS: There was no difference in masseter muscle oxygenation among groups. In the masseter muscle, a weakly positive correlation was observed between PPT and variation in tissue saturation index in the MG (rho = 0.365) and JG (rho = 0.317). In addition, the MJG expressed lower PPT (p = 0.004) than JG, demonstrating that MJG had more pain in this muscle. CONCLUSIONS: MJG have lower PPT in the masseter muscle. Although the PPT is dependent on the type of TMDs, the correlation between PPT and oxygenation is weak. All TMDs groups evaluated (MG, JG, MJG) showed hemodynamic similarities of the masseter muscle. CLINICAL RELEVANCE: Understanding pain thresholds and the hemodynamic behavior of the masticatory muscles contributes to a more assertive physiotherapeutic assessment in TMDs, serving as a basis for careful and individualized interventions.

Chlorella vulgaris-mediated bioremediation of food and beverage wastewater from industries in Mexico: Results and perspectives towards sustainability and circular economy.

The food and beverage industries in Mexico generate substantial effluents, including nejayote, cheese-whey, and tequila vinasses, which pose significant environmental challenges due to their extreme physicochemical characteristics and excessive organic load. This study aimed to assess the potential of Chlorella vulgaris in bioremediating these complex wastewaters while also producing added-value compounds. A UV mutagenesis treatment (40 min) enhanced C. vulgaris adaptability to grow in the effluent conditions. Robust growth was observed in all three effluents, with nejayote identified as the optimal medium. Physicochemical measurements conducted pre- and post-cultivation revealed notable reductions of pollutants in nejayote, including complete removal of nitrogen and phosphates, and an 85 % reduction in COD. Tequila vinasses exhibited promise with a 66 % reduction in nitrogen and a 70 % reduction in COD, while cheese-whey showed a 17 % reduction in phosphates. Regarding valuable compounds, nejayote yielded the highest pigment (1.62 mg·g-1) and phenolic compound (3.67 mg·g-1) content, while tequila vinasses had the highest protein content (16.83 %). The main highlight of this study is that C. vulgaris successfully grew in 100 % of the three effluents (without additional water or nutrients), demonstrating its potential for sustainable bioremediation and added-value compound production. When grown in 100 % of the effluents, they become a sustainable option since they don't require an input of fresh water and therefore do not contribute to water scarcity. These findings offer a practical solution for addressing environmental challenges in the food and beverage industries within a circular economy framework.

Supereu e neurose: dos pecados do pai à demanda do Outro, "Goza! / Surmoi et névrose: des péchés du père aux demandes de l'Autre, "Jouis !" / Superego and neurosis: from the sins of the father to the demands of the Other, "Enjoy!"

Neste artigo, por meio do arcabouço freudo-lacaniano, analisou-se teoricamente o supereu na neurose, com o objetivo de investigar suas especificidades e seus truques, que invariavelmente levam o sujeito ao pior. O neurótico demanda amor, demanda ser demandado e recebe suas próprias demandas de forma invertida como demanda do Outro. Então, pelas fraturas da metáfora paterna, o supereu na neurose articula seus imperativos à demanda do Outro obstruindo o desejo, o que pode ser demonstrado com a figura do toro e com o grafo do desejo. Conclui-se, com a importância de pesquisar o supereu que carrega mistérios, paradoxos e sutilezas, que ainda deixam perguntas, também diferenciando as estratégias e os modos de gozo que essa instância impõe à neurose e com o destino do supereu no final de análise.

Dans cet article, à travers le cadre freudo-lacanien, le surmoi dans la névrose est analysé théoriquement, dans le but d'enquêter sur ses spécificités et ses astuces, qui conduisent invariablement le sujet au pire. Le névrosé demande de l'amour, demande à être demandé et reçoit ses propres demandes de façon inversée comme la demande de l'Autre. Puis, à travers les fractures de la métaphore paternelle, le surmoi dans la névrose articule ses impératifs à la demande de l'Autre, obstruant le désir, ce qui peut être démontré avec la figure du tore et avec le graphe du désir. Il se conclut sur l'importance de rechercher le surmoi porteur de mystères, de paradoxes et de subtilités, qui laisse encore desinterrogations, en différenciant également les stratégies et les modes de jouissance que cette instance impose à la névrose et avec le destin du surmoi au fin de l'analyse.

In this article, through the Freudian-Lacanian framework, the superego in neurosis was theoretically analyzed, with the aim of investigating its specificities and its tricks, which invariably lead the subject to the worst. The neurotic demands love: they demand to be demanded and also receive their own demands in an inverted way as the Other's demand. Then, through the fractures of the paternal metaphor, the superego in neurosis articulates its imperatives to the demand of the Other, obstructing desire. We try to demonstrate this unconscious operation with the figure of the torus and with the graph of desire. It concludes with the importance of researching the superego that carries mysteries, paradoxes and subtleties, which still leave questions, also differentiating the strategies and modes of jouissance that this instance imposes on neurosis and with the destiny of the superego at the end of the analysis.

Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Assessment and management of postoperative anemia.

Postoperative anemia is a complex clinical issue that requires attention due to its ramifications on the patient's recovery and prognosis. Originating from multiple determinants, such as intraoperative blood loss, hemolysis, nutritional deficiencies, systemic inflammation and impact on the bone marrow, postoperative anemia has varied and often challenging presentations. Patients undergoing major surgical procedures, in particular, are susceptible to developing anemia due to the considerable associated blood loss. Accurate diagnosis plays a crucial role in the approach, requiring meticulous hematological analysis, including hemoglobin, hematocrit and reticulocyte count, as well as an in-depth investigation of the underlying causes. An additional challenge arises in the form of the excessive practice of phlebotomy during hospitalization for clinical monitoring. Although it is essential to assess the progression of anemia, frequent removal of blood may contribute to iatrogenic anemia, further delaying recovery and possibly increasing susceptibility to infection.

Orthodontic treatment demand for fixed treatment and aligners among young adults in middle Europe and South America - a questionnaire study.

BACKGROUND: Patients experiencing any malocclusion, may desire for treatment. However, there is no scientific information orthodontic treatment demand and the knowledge of young adults about orthodontic treatment. The aim of the study was to assess orthodontic treatment demand in young adults from Poland and Chile, their previous orthodontic experience and their knowledge on fixed and aligner orthodontic treatment. METHODS: The target group comprised people aged 18-30. The sample size was estimated as above 400 for each country. The survey was carried out in Polish and Spanish within 3 months and consisted of 25 questions delivered via social media. Comparisons were made between countries, age subgroups and gender. RESULTS: The response rate was 1,99%, what stands for 1092 responses, 670 from Chile and 422 from Poland, respectively. The percentage of young adults who were already treated was 42,9% in Poland and 25,0% in Chile. The ones planning to have orthodontic treatment within a year counted for 11,8% in Poland and 5,3% in Chile. Most young adults who want to be treated (20,6%) rely on doctor's recommendation on type of appliance while 14,7% of all respondents are interested solely in aligners. Most respondents have heard about aligners (58%). Direct provider-to-customer service without a doctor is not acceptable, neither in Poland (85,1%) nor in Chile (64,8%). Most young adults provided incorrect answers referring various aspects of aligner treatment. CONCLUSIONS: In both countries, patients demand to be treated and monitored by the orthodontist. A high percentage of patients want to be treated exclusively with aligners. Direct-to-consumer orthodontics does not seem attractive to patients. Young adults do not have adequate knowledge referring to aligner treatment. Many people want to be treated despite a previous orthodontic treatment.

Trends in research on cacti: the food of the future.

Cacti are a distinguished group of plants that stand out for their great nutritional values, diverse uses, and unique morphology, allowing them to grow and thrive under different conditions such as dry, xeric, and even low-temperature environments. The world is going through significant climate changes that are affecting the agriculture system. Therefore, sustainable and multifunctional crops, as many species of the Cactaceae family are, might be a good alternative in the near future. In this work, the uses of cacti in human food were analyzed through a scientific prospection from the point of view of their temporal and spatial distribution and potential uses. Brazil is the country with more publications related to the scope of this work, followed by Mexico. The presence of cacti in these countries can influence their interest in these species, which might reflect the results encountered in this study. The uses and ethnobotanical applications of cacti vary in different countries worldwide. Cactus is consumed fresh (in salads), in preparations (jams and sweets), and juices, being also present in traditional dishes in countries like Mexico. This study emphasizes cacti's importance in people's diets and ongoing world changes. Their ability to thrive even in hot environments with low water resources will lead to a greater focus on these species in the upcoming years. Furthermore, these plants have great flavor and contain several beneficial chemical compounds with desirable nutritional and health properties. Therefore, knowledge dissemination combined with technological innovations will allow greater use of these multifunctional species for human consumption. © 2024 Society of Chemical Industry.

A methodology to simulate peak water demand for water supply systems using semi-direct methods: A case study for a residential building in Mexico.

Historically, approaches for determining peak water demand in buildings have been based on probabilistic methods. Extensive research has shown that these methods lack accuracy because of the human factor in the probability of use. Inaccuracy in the calculation of peak water demand is the main cause of oversized water supply systems in buildings. This has led to unfavorable effects such as: 1) increasing the building carbon footprint due to the use of more construction materials, and 2) engendering health hazards due to the stagnation of water causing microbial growing. This paper presents a step-by-step methodology that serves to calculate the peak water demand by simulating the use of plumbing fixtures based on data obtained from standardized flowrate. With the implementation of the methodology, the peak water demand estimated was 2.6 times lower in comparison to traditional methods. The main conclusion drawn from the research is the potential of the methodology to easily simulated peak water demand in residential buildings in the short term. Thus, it reveals a hotspot for peak water demand calculation and can serve as routes for future research.

Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas.

In recent decades, the poultry farming industry has assumed a pivotal role in meeting the global demand for affordable animal proteins. While poultry farming makes a substantial contribution to food security and nutrition, it also presents environmental and public health challenges. The use of poultry litter as fertilizer for agricultural soils raises concerns about the transfer of pathogens and drug-resistant microorganisms from poultry farms to crop production areas. On the other hand, according to the Food and Agriculture Organization of the United Nations (FAO), fungicides represent the second most used chemical group in agricultural practices. In this context, agricultural soils receive the application of both poultry litter as a fertilizer and fungicides used in agricultural production. This practice can result in fungal contamination of the soil and the development of antifungal resistance. This article explores the necessity of monitoring antifungal resistance, particularly in food production areas with co-application of poultry litter and fungicides. It also highlights the role of fungi in ecosystems, decomposition, and mutualistic plant associations. We call for interdisciplinary research to comprehensively understand fungal resistance to fungicides in the environment. This approach seeks to promote sustainability in the realms of human health, agriculture, and the environment, aligning seamlessly with the One Health concept.

Demand charges reduction with photovoltaics in industry.

Demand charges are widely used for commercial and industrial consumers. These costs are often not well known, let alone the effects that PV can have on them. This work proposes a methodology to assess the effect of PV on reducing these charges and to optimise the power to be contracted, using techniques taken from exploratory data analysis. This methodology is applied to five case studies of industrial consumers from different sectors in Spain, finding savings between 5 % and 11 % of demand charges in industries with continuous operation and up to 28 % in cases of discontinuous operation. These savings can be even greater if the maximum power that can be contracted is lower than the optimum. The demand charges in Spain consist of a fixed part proportional to the contracted power and a variable part depending on the power peaks exceeding it. Since for the variable part the coincident and non-coincident models coexist, a comparison is made between the two models, finding that in the general case PV users can achieve higher savings with the coincident model.

Use of a Modelling Tool to Optimise the Organisation of the Demand for Primary Oral Health Care in the Brazilian Unified Health System.

PURPOSE: To describe the use of work process modelling to optimise the organisation of the demand for oral health treatment in primary care units in Brazil. MATERIALS AND METHODS: The oral health care routine was at first described as the "AS IS" model, which was evaluated by the oral team professionals, rearranged, and further described as the "TO BE" model described using a business process management modelling tool. The significant increase in the demand of patients due to restrictions offered by the dental service in addition to non-urgent treatments being avoided by patients during COVID-19 pandemic was also considered. RESULTS: Structuring the work processes in a visual way using modelling tools was useful to picture the entire treatment process and adjust when needed. The use of the managerial tool was useful to understand and reorganise the workflow of organising the demand and ultimately improve the efficiency of the resources. The use of such managerial tools helped oral health professionals to efficiently rearrange their tasks and set priorities to meet their needs. CONCLUSIONS: With the use of management tools, each unit can readjust its structures and ways of working, aiming to improve the quality of public health care services provided to patients.

Systematic Review of Literature on Vocal Demand Response: Understanding Physiology, Measurements, and Associated Factors.

PURPOSE: Considering the conceptual migration from vocal load and vocal loading to vocal demand and vocal demand response, this review of literature aimed to identify physiological explanations, reported measurements, and associated factors (vocal demands) reported in the literature when considering the phonatory response to a vocal demand. METHODS: A systematic review of literature, following the PRISMA Statement, was conducted using Web of Science, PubMed, Scopus, and ScienceDirect. Data were analyzed and presented in two parts. First, a bibliometric analysis, co-occurrence analysis, and content analysis were performed. Three criteria that got article inclusion were defined: (1) written in English, Spanish, and Portuguese; (2) published between 2009 and 2021; and (3) focused on vocal load and loading, vocal demand response, and voice assessment parameters. A total of 54 publications met the criteria and were included in this review. The second part included a conceptual framework based on the content analysis of three aspects of vocal demand response: (1) physiological explanations, (2) reported measurements, and (3) vocal demands. RESULTS AND CONCLUSION: As would be expected since vocal demand response is a relatively new term and not yet commonly used in literature when discussing way that the speakers respond to communicative scenarios, most of the studies reviewed (both historical and recent) still use the term of vocal load and vocal loading. Although there is a broad variety of literature discussing a wide range of vocal demands and voice parameters used to characterize the vocal demand response, results show that there is consistency across the studies. While vocal demand response is unique and intrinsic to the talker, associated factors that contribute to this response include both internal talker and external talker factors. Internal factors include muscle stiffness, viscosity in the phonatory system, vocal fold tissue damage, elevated sound pressure levels during occupational voice demands, extended periods of voice use, suboptimal body posture, difficulties in breathing technique, and sleep disturbances. Associated external factors include the working environment (noise, acoustics, temperature, humidity). In conclusion, although vocal demand response is intrinsic to the speaker, the speaker's response is affected by external vocal demands. However, due to the wide methods to evaluate vocal demand response, it has been difficult to establish its contribution to voice disorders in the general population and, specifically, among occupational voice users. This literature review identified commonly reported parameters and factors that may help clinicians and researchers define vocal demand response.

Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Assessment and management of postoperative anemia

Abstract Postoperative anemia is a complex clinical issue that requires attention due to its ramifications on the patient's recovery and prognosis. Originating from multiple determinants, such as intraoperative blood loss, hemolysis, nutritional deficiencies, systemic inflammation and impact on the bone marrow, postoperative anemia has varied and often challenging presentations. Patients undergoing major surgical procedures, in particular, are susceptible to developing anemia due to the considerable associated blood loss. Accurate diagnosis plays a crucial role in the approach, requiring meticulous hematological analysis, including hemoglobin, hematocrit and reticulocyte count, as well as an in-depth investigation of the underlying causes. An additional challenge arises in the form of the excessive practice of phlebotomy during hospitalization for clinical monitoring. Although it is essential to assess the progression of anemia, frequent removal of blood may contribute to iatrogenic anemia, further delaying recovery and possibly increasing susceptibility to infection.

Vocal Demand Response to the Educational Setting Based Communication Scenarios: A Single Subject Study

Objectives: This was a single-subject study, aimed to demonstrate different vocal demand situations that are typical for primary school and teacher's vocal demand response under two acoustical conditions, with and without voice amplification, during five working days. Methods: The long-term voice dosimetry with Vocal Holter Med (PR.O. Voice Srl) was carried out on a 49-year-old female teacher with voice disorders during daily teaching activities. A sound field amplification system (SFAS) PentaClass Runa was installed in the classroom. Voice dosimetry was provided under two different acoustical conditions: without SFAS (2 days) and with SFAS (3 days). Results: Phonation time percentage, sound pressure level (SPL), SPL SD, fundamental frequency (F0), F0 SD, cycle, and distance doses were investigated in seven communication scenarios (lessons, group/individual classes, sports lessons in the gym and schoolyard, breaks, lunch breaks, and other activities). The median scores of all voice parameters differed significantly between different vocal demand contexts. The significant statistical difference in the vocal demand response was in the communication situations with and without SFAS. In addition, the number of children, reverberation time, and ambient air relative humidity impacted voice SPL and the cycle dose. Conclusions: Lessons, sports lessons held in the gym or schoolyard, breaks, and lunch breaks were considered as high vocal demand communication situations requiring higher voice intensity and fundamental frequency, higher phonation time percentage, cycle, and distance doses. Group/individual work and other teacher activities during the day, unrelated to direct work with students, were categorized as low vocal demand communication scenarios.

Objetivos: Este fue un estudio de sujeto único, cuyo objetivo fue demostrar diferentes situaciones de demanda vocal típicas de la escuela primaria y la respuesta vocal de los docentes bajo dos condiciones acústicas, con y sin amplificación de voz, durante cinco días laborables. Métodos: Se llevó a cabo dosimetría vocal a largo plazo con Vocal Holter Med (PR.O. Voice Srl) durante las actividades diarias de enseñanza en una docente de 49 años con trastornos de la voz. Se instaló un sistema de amplificación de campo sonoro (SFAS) PentaClass Runa en el aula. La dosimetría vocal se realizó bajo dos condiciones acústicas diferentes: sin SFAS (2 días) y con SFAS (3 días). Resultados: Se investigaron el porcentaje de tiempo de fonación, el nivel de presión sonora (SPL), SPL SD, la frecuencia fundamental (F0), F0 SD, ciclos y dosis de distancia en siete escenarios de comunicación diferentes (clases, clases grupales/individuales, clases de educación física en el gimnasio y el patio de la escuela, recreos, almuerzos y otras actividades). Las puntuaciones medias de todos los parámetros vocales diferían significativamente entre los diferentes contextos de demanda vocal. La diferencia estadísticamente significativa en la respuesta a la demanda vocal se observó en las situaciones de comunicación con y sin SFAS. Además, el número de niños, el tiempo de reverberación y la humedad relativa del aire ambiente afectaron al SPL de la voz y la dosis de ciclo. Conclusiones: Las lecciones, las clases de educación física en el gimnasio o el patio de la escuela, los recreos y los almuerzos se consideraron situaciones de comunicación de alta demanda vocal, que requerían una mayor intensidad y frecuencia fundamental de la voz, un mayor porcentaje de tiempo de fonación y dosis de ciclo y distancia más altas. El trabajo grupal/individual y otras actividades del profesor durante el día no relacionadas con el trabajo directo con los estudiantes se categorizaron como escenarios de comunicación de baja demanda vocal.

Demanda de servicios de salud de la población adulta mayor de bajos ingresos en Colombia

Objetivo: Analizar los determinantes de la demanda de servicios de salud del adulto mayor entre los segmentos más pobres de Colombia. Materiales y métodos: Estudio de datos panel a partir de datos de riesgo individualizado de una aseguradora del régimen subsidiado en Colombia. Se elaboraron modelos de regresión lineal para determinar la demanda de salud bajo dos escenarios. Resultados: El hacinamiento, la exposición al humo y roedores mantienen una relación positiva con la demanda de servicios de salud. Por el contrario, la educación, ocupación, realizar actividad física y el no consumo de alcohol son factores protectores. Conclusión: La transición demográfica y epidemiológica que experimenta Colombia trae consigo retos para el sistema de salud. La identificación de determinantes de la demanda contribuye al establecimiento de estrategias para el mejoramiento del sistema de salud vigente y futuro.

Objective: To analyze the determinants of the demand for health services of the elderly among the poorest segments in Colombia. Materials and methods: Panel data study based on individualized risk data from an insurer of the subsidized regime in Colombia. Linear regression models were developed to determine health demand under two scenarios. Results: Overcrowding, exposure to smoke and rodents maintain a positive relationship with the demand for health services. On the contrary, education, occupation, physical activity, and non-alcohol consumption are protective factors. Conclusion: The demographic and epidemiological transition that Colombia is experiencing brings challenges to the health system. The identification of determinants of demand contributes to the implementation of strategies to improve the current and future health system.

Percepciones del personal de salud sobre los efectos de la pandemia COVID-19 en un servicio de salud mental y adicciones

Objetivo: Analizar las percepciones del personal de salud sobre los efectos de la pandemia por COVID-19 en la organización de un servicio de salud mental y adicciones. Materiales y métodos: Estudio descriptivo, transversal, cuantitativo. Se aplicó una encuesta diseñada por el Observatorio Argentino de Drogas de la SEDRONAR (Secretaría de Políticas sobre Drogas de la Nación Argentina) al personal de salud del Centro Asistencial Córdoba durante el mes de noviembre 2020. Resultados: Según las percepciones del personal de salud, la institución sostuvo la admisión y la suspensión fue solamente sobre las prestaciones de terapia grupal durante la primera etapa, que se revirtió desarrollando grupos terapéuticos mediante videollamadas. En relación con la variación de la demanda de atención, el 68,9% mencionó estar totalmente en desacuerdo con la afirmación de que la misma disminuyó. El personal de salud observó una variabilidad en los motivos de consulta y un aumento en la demanda de atención, con un crecimiento de las consultas por violencia autoinfligida y por consumos problemáticos de sustancias. Conclusión: Las medidas de aislamiento implicaron una reorganización de los servicios y sus modalidades de atención. Se torna importante preparar a los servicios de salud mental y adicciones para brindar las prestaciones necesarias y dar respuesta a las demandas de atención durante este tipo de contingencias.

Objetive: To analyze the perceptions of health personnel about the effects of the COVID-19 pandemic on the organization of a mental health and drug abuse service. Materials and Methods: A descriptive, cross-sectional and quantitative. A survey designed by the Argentine Drugs Observatory of SEDRONAR (Secretaría de Políticas sobre Drogas de la Nación Argentina) was applied to all the health professionals at Centro Asistencial Córdoba during November 2020. Results: According to the perceptions of health personnel, the organization kept admissions open for new treatments and the suspension was only about group therapy benefits during the first moment of lockdown measures, which was reversed by developing therapeutic groups through video calls. Regarding the change in demand for attention, 68, 9% mentioned being totally at odds with the claim that it diminished. Health personnel perceived a variability in the reasons for consultation and an increase in the demand for attention with a growth in consultations due to self-inflicted violence and substance-related disorders. Conclusion: It is possible to conclude that lockdown measures involved a reorganization of services and their modalities of attention. Therefore, it becomes important to prepare mental health services and substance-related disorders to provide the necessary benefits and respond to the demands for attention during this type of critical incidents.

Demand creation and retention strategies for oral pre-exposure prophylaxis for HIV prevention among men who have sex with men and transgender women: a systematic review and meta-analysis.

BACKGROUND: Men who have sex with men (MSM) and transgender women (TGW) have a disproportionately higher risk of human immunodeficiency virus (HIV) infection than other groups. Oral HIV pre-exposure prophylaxis (PrEP) is an effective prevention tool and should be offered to those at higher risk. Identifying demand creation strategies (DCS) and retention strategies (RS) to improve PrEP persistence is essential to control the HIV epidemic. AIM: We aimed to identify the (DCS and RS with higher proportions among MSM and TGW. METHODS: A systematic review and meta-analysis of prospective studies were conducted, with studies retrieved from five databases until November, 2022 following the Cochrane and PRISMA guidelines. The study protocol was registered in PROSPERO (CRD42022323220). The outcomes were DCS and RS for PrEP use among MSM and TGW. Strategies used for users enrolled in the PrEP-recruited (DCS) were classified as face-to-face (peer educator recruitment at social venues, nongovernmental organizations, and parties; direct referrals by health services; friends and/or sexual partners); online (chatbot or peer educator recruitment on social media [e.g., , Instagram or Facebook] or dating/hook-up apps [e.g., Grindr, Tinder, Badoo, and Scruff]); and mixed (face-to-face and online). RS was classified as provider counseling (face-to-face by a health professional; prevention of HIV risk counseling, distribution of condoms, lubricants, and testing for HIV or other sexually transmitted infections); online counseling (text messages, chatbots, telephone calls, social media, and peer educators); and mixed (all previous strategies). Subgroup analyses were conducted for each treatment strategy. Meta-analyses were performed using the R software version 4.2.1. RESULTS: A total of 1, 129 studies were retrieved from the five databases. After eligibility, 46 studies were included. For MSM, most DCS and RS were online at 91% (95% CI: 0.85-0.97; I2=53%), and 83% (95% CI: 0.80-0.85; I2=17%) respectively. For TGW, mixed DCS and RS were the most frequent at85% (95% CI: 0.60-1.00; I2=91%) and online counseling at 84% (95% CI: 0.64-0.95) compared to other strategies. CONCLUSION: Critical issues play. Pivotal role in increasing PrEP awareness among MSM and TGW, minimizing access gaps, and ensuring retention of PrEP services. Offering oral PrEP using online DCS and RS can reach and retain high numbers of MSM and TGW, and reduce HIV incidence in these populations.

Demanda, oferta e produção de cateterismo cardíaco no Estado do Rio de Janeiro / Demand, offer and production of cardiac catheterization in the state of Rio de Janeiro

Este trabalho, de caráter exploratório-descritivo, objetiva descrever a produção de serviços e a demanda ao Sistema Estadual de Regulação (SER), sistema responsável pela regulação do procedimento, aos serviços de cateterismo no estado do Rio de Janeiro, sob a ótica das regiões de saúde, com seus desafios e entraves regionais. O acesso oportuno e integral garantido pela Lei 8.080/1990 norteiam este trabalho quanto à análise da capacidade de oferta do procedimento de alta complexidade no estado do Rio de Janeiro. O planejamento em saúde também é abordado como instrumento viabilizador da garantia, para a população, do acesso à assistência, estabelecendo referências e fluxos de processos. O trabalho apresenta a produção por região de saúde e a distribuição de vagas ofertadas pelo estado através do Sistema Estadual de Regulação, evidenciando a rede de assistência habilitada em cateterismo, bem como o índice de aproveitamento dos recursos. A concentração da produção de cateterismo no estado do Rio de Janeiro é observada na Região Metropolitana I, onde há um agrupamento de hospitais habilitados no procedimento. No universo de 23 estabelecimentos hospitalares de alta complexidade cardiovascular, 52% são filantrópicos, 39% públicos e 9% são privados. A pesquisa busca ainda mostrar as disparidades entre a relação da produção realizada e a oferta de vagas do estado para esse procedimento. Este trabalho busca compreender, sem esgotar, o funcionamento da rede de alta complexidade cardiovascular no que diz respeito ao cateterismo no estado do Rio de Janeiro. (AU)

This work, of an exploratory and descriptive nature, aims to describe the production of services and the demand for the State Regulation Service (SER), the system responsible for regulating the procedure, for catheterization services in the state of Rio de Janeiro, from the perspective of health regions, with their challenges and regional obstacles. The timely and comprehensive access guaranteed by Law 8,080/1990 guides the evolution of this work regarding the analysis of the capacity to offer the highly complex procedure in the state of Rio de Janeiro. Health planning is also approached as an instrument to ensure access to care for the population, establishing references and process flows. The work presents production by health region and the distribution of vacancies offered by the state through the State Regulation System, highlighting the assistance network qualified in catheterization as well as the rate of use of resources. The concentration of catheterization production in the state of Rio de Janeiro is observed in metropolitan region I, where there is a group of hospitals qualified in the procedure. In the universe of 23 highly complex cardiovascular hospital establishments, 52% are philanthropic, 39% public and 9% are private. The research also seeks to show the disparities between the relationship between the production carried out and the state's supply of vacancies for this procedure. This work seeks to understand, without exhausting, the functioning of the highly complex cardiovascular network regarding catheterization in the state of Rio de Janeiro. (AU)

School of cheminformatics in Latin America.

We report the major highlights of the School of Cheminformatics in Latin America, Mexico City, November 24-25, 2022. Six lectures, one workshop, and one roundtable with four editors were presented during an online public event with speakers from academia, big pharma, and public research institutions. One thousand one hundred eighty-one students and academics from seventy-nine countries registered for the meeting. As part of the meeting, advances in enumeration and visualization of chemical space, applications in natural product-based drug discovery, drug discovery for neglected diseases, toxicity prediction, and general guidelines for data analysis were discussed. Experts from ChEMBL presented a workshop on how to use the resources of this major compounds database used in cheminformatics. The school also included a round table with editors of cheminformatics journals. The full program of the meeting and the recordings of the sessions are publicly available at https://www.youtube.com/@SchoolChemInfLA/featured .