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1.
Spectrochim Acta A Mol Biomol Spectrosc ; 326: 125163, 2024 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-39366312

RESUMO

Er3+-doped glasses and fibers with broadband near infrared (NIR) emission have been widely applied in EDFA. Limited by optical gain band of Er3+-doped glasses and fibers, it was hardly meet to the demands of broadband amplification in the C + L band. In this work, six glass matrixes were employed for discussing the influence of glass matrix on the Stark splitting of Er3+ and the wavelength of laser output and amplification. The larger scalar crystal-field parameter NJ induce larger Stark splitting of Er3+-doped tellurite, germanate, and fluorophosphate glasses, which resulted in larger Δλeff. The Stark splitting of Er3+-doped tellurite, germanate, silicate, and phosphate glasses was mainly derived from homogeneous broadening, which be favor to obtain longer wavelength amplification and laser output. While that of Er3+-doped fluorophosphate and aluminate glasses was mainly derived from the inhomogeneous broadening, the amplification and laser output of Er3+ tend to operate in the shorter wavelength.

2.
Heliyon ; 10(16): e35899, 2024 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-39220948

RESUMO

The present study aimed to investigate the effect of frame tightness on the wearing comfort of augmented reality (AR) glasses during a prolonged video viewing task. A frame prototype of AR glasses with an adjustable frame width was adopted to accommodate variations in head size within the Chinese population, and two hundred participants were recruited to wear the glasses for an hour under five different tightness conditions. Local and overall discomfort ratings were obtained as outcome measures, and the ratings exhibited a significant increase with higher tightness levels. Furthermore, females and older people reported greater discomfort than other participants did, whereas previous spectacle use and body type had nonsignificant effects on wearing comfort. Consideration of approaches to alleviate frame tightness is crucial in the design of AR glasses targeting females and older people. These findings provide valuable ergonomic insights for AR glasses design and offer considerations applicable to the glasses-type wearable device industry.

3.
J Phys Condens Matter ; 36(50)2024 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-39270721

RESUMO

We report on the CrFeTi2O7(CFTO) system using a combination of x-ray diffraction, dc magnetization, ac susceptibility, specific heat and neutron diffraction measurements. CFTO is seen to crystallize in a monoclinicP21/asymmetry. It shows a glassy freezing atTf∼22 K, characterized by the observation of bifurcation between ZFC and FCχ(T) curves, frequency dispersion acrossTfin ac susceptibility, and follows Vogel-Fulcher and power law type critical dynamics, very slow relaxation of iso-thermal remanent magnetization with time and a linear temperature dependence of magnetic contribution to specific heatCmbelowTf. The microscopic neutron diffraction analysis of CFTO not only confirms the absence of long-range antiferromagnetic (AFM) ordering but also exhibits diffuse scattering due to the presence of short-range ordered AFM correlated spin clusters.

4.
Chemphyschem ; : e202400370, 2024 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-39229812

RESUMO

Understanding how the surface structure affects the bioactivity and degradation rate of the glass is one of the primary challenges in developing new bioactive materials. Here, classical and reactive molecular dynamics simulations are used to investigate the relationship between local surface chemistry and local adsorption energies of water on three soda-lime silicate glasses.  The compositions of the glasses, (SiO2)(65-x)(CaO)35(Na2O)x with x = 5, 10, and 15, were chosen for their bioactive properties. Analysis of the glass surface structure, compared to the bulk structure, showed that the surface is rich in modifiers and non-bridging oxygen atoms, which were correlated with local adsorption energies. The reactivity of the glasses is found to increase with higher Na2O content, attributed to elevated Na cations and undercoordinated species at the glass surfaces. The current work provides insights into the relationship between the surface structure, chemistry, and properties in these bioactive glasses and offers a step toward their rational design.

5.
J Clin Lab Anal ; : e25094, 2024 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-39235180

RESUMO

AIM: This study aimed to investigate the effects of 45S5 bioactive glass-ointment (BG) on cutaneous wound healing in rats at the molecular, biochemical, and histopathological levels. MATERIALS AND METHODS: Thirty-two rats were divided into four groups (n = 8): Control, Sham, BG, and DEX (Dexpanthenol). While no wound treatment was applied to the CONTROL, a wound model was created in the Sham, and no treatment was applied. A wound model was created for other groups, and BG and DEX were applied locally for 21 days. During the 21-day experiment period, feed and water consumption and weight changes were observed. Wound areas were calculated on days 0, 3, 7, 4, and 21. Following treatment, the rats were euthanized and tissues from the wound area and blood samples were collected. While the expression levels of tumor necrosis factor-alpha (TNFα), Interleukin 6 (IL6), Interleukin 10 (IL10), transforming growth factor-beta (TGFß), and vascular endothelial growth factor (VEGF) genes were determined by qPCR, the levels of TNFα, IL6, and IL10 proteins were measured by ELISA. RESULTS: It was observed that the BG group showed anti-inflammatory activity by suppressing TNFα levels and stimulating IL-10. In addition, it was determined that BG increased fibroblast activity and vascularization. CONCLUSION: Current findings showed that topical application of BG has anti-inflammatory effects, while also accelerating healing by increasing vascularity and making positive contributions to tissue healing.

6.
J Funct Biomater ; 15(9)2024 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-39330233

RESUMO

Bioactive glasses (BGs) have attracted significant attention in the biomaterials field due to their ability to promote soft and hard tissue regeneration and their potential for various clinical applications. BGs offer enriched features through the integration of different therapeutic inorganic ions within their composition. These ions can trigger specific responses in the body conducive to a battery of applications. For example, zinc, a vital trace element, plays a role in numerous physiological processes within the human body. By incorporating zinc, BGs can inhibit bacterial growth, exert anti-inflammatory effects, and modify bioactivity, promoting better integration with surrounding tissues when used in scaffolds for tissue regeneration. This article reviews recent developments in zinc-containing BGs (ZBGs), focusing on their synthesis, physicochemical, and biological properties. ZBGs represent a significant advancement in applications extending beyond bone regeneration. Overall, their biological roles hold promise for various applications, such as bone tissue engineering, wound healing, and biomedical coatings. Ongoing research continues to explore the potential benefits of ZBGs and to optimize their properties for diverse clinical applications.

7.
JMIR Mhealth Uhealth ; 12: e59469, 2024 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-39325528

RESUMO

BACKGROUND: The increasing prevalence of obesity necessitates innovative approaches to better understand this health crisis, particularly given its strong connection to chronic diseases such as diabetes, cancer, and cardiovascular conditions. Monitoring dietary behavior is crucial for designing effective interventions that help decrease obesity prevalence and promote healthy lifestyles. However, traditional dietary tracking methods are limited by participant burden and recall bias. Exploring microlevel eating activities, such as meal duration and chewing frequency, in addition to eating episodes, is crucial due to their substantial relation to obesity and disease risk. OBJECTIVE: The primary objective of the study was to develop an accurate and noninvasive system for automatically monitoring eating and chewing activities using sensor-equipped smart glasses. The system distinguishes chewing from other facial activities, such as speaking and teeth clenching. The secondary objective was to evaluate the system's performance on unseen test users using a combination of laboratory-controlled and real-life user studies. Unlike state-of-the-art studies that focus on detecting full eating episodes, our approach provides a more granular analysis by specifically detecting chewing segments within each eating episode. METHODS: The study uses OCO optical sensors embedded in smart glasses to monitor facial muscle activations related to eating and chewing activities. The sensors measure relative movements on the skin's surface in 2 dimensions (X and Y). Data from these sensors are analyzed using deep learning (DL) to distinguish chewing from other facial activities. To address the temporal dependence between chewing events in real life, we integrate a hidden Markov model as an additional component that analyzes the output from the DL model. RESULTS: Statistical tests of mean sensor activations revealed statistically significant differences across all 6 comparison pairs (P<.001) involving 2 sensors (cheeks and temple) and 3 facial activities (eating, clenching, and speaking). These results demonstrate the sensitivity of the sensor data. Furthermore, the convolutional long short-term memory model, which is a combination of convolutional and long short-term memory neural networks, emerged as the best-performing DL model for chewing detection. In controlled laboratory settings, the model achieved an F1-score of 0.91, demonstrating robust performance. In real-life scenarios, the system demonstrated high precision (0.95) and recall (0.82) for detecting eating segments. The chewing rates and the number of chews evaluated in the real-life study showed consistency with expected real-life eating behaviors. CONCLUSIONS: The study represents a substantial advancement in dietary monitoring and health technology. By providing a reliable and noninvasive method for tracking eating behavior, it has the potential to revolutionize how dietary data are collected and used. This could lead to more effective health interventions and a better understanding of the factors influencing eating habits and their health implications.


Assuntos
Aprendizado Profundo , Comportamento Alimentar , Óculos Inteligentes , Humanos , Comportamento Alimentar/psicologia , Comportamento Alimentar/fisiologia , Estudos Transversais , Feminino , Masculino , Adulto , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Mastigação/fisiologia
8.
Materials (Basel) ; 17(18)2024 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-39336328

RESUMO

This article reviews the research and development focus of metallic glasses in the field of biomedical applications. Metallic glasses exhibit a short-range ordered and long-range disordered glassy structure at the microscopic level, devoid of structural defects such as dislocations and grain boundaries. Therefore, they possess advantages such as high strength, toughness, and corrosion resistance, combining characteristics of both metals and glasses. This novel alloy system has found applications in the field of biomedical materials due to its excellent comprehensive performance. This review discusses the applications of Ti-based bulk metallic glasses in load-bearing implants such as bone plates and screws for long-term implantation. On the other hand, Mg-based metallic glasses, owing to their degradability, are primarily used in degradable bone nails, plates, and vascular stents. However, metallic glasses as biomaterials still face certain challenges. The Young's modulus value of Ti-based metallic glasses is higher than that of human bones, leading to stress-shielding effects. Meanwhile, Mg-based metallic glasses degrade too quickly, resulting in the premature loss of mechanical properties and the formation of numerous bubbles, which hinder tissue healing. To address these issues, we propose the following development directions: (1) Introducing porous structures into titanium-based metallic glasses is an important research direction for reducing Young's modulus; (2) To enhance the bioactivity of implant material surfaces, the surface modification of titanium-based metallic glasses is essential. (3) Developing antibacterial coatings and incorporating antibacterial metal elements into the alloys is essential to maintain the long-term effective antibacterial properties of metallic biomaterials. (4) Corrosion resistance must be further improved through the preparation of composite materials, while ensuring biocompatibility and safety, to achieve controllable degradation rates and degradation modes.

9.
Vision Res ; 224: 108488, 2024 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-39305648

RESUMO

The receptive field (RF) is the fundamental processing unit of human vision; both masking and crowding depend on its size. The RF has a psychophysical corresponding term, the perceptive field (PF); whereas the RF is measured physiologically, the PF is measured psychophysically (a perceptual response). We investigated how spatial (lateral interactions), temporal (the stimulus presentation time), and the procedure affect the PF size for both monocular and binocular viewing. The stimuli consisted of a central vertically oriented Gabor target and high-contrast Gabor flankers positioned in two configurations (orthogonal or collinear) with target-flanker separations of either 2 or 3 wavelengths (λ). We used two main methods to control the monocular and binocular vision: mono-optic glasses vs. stereo glasses. The presentation order was either mixed or non-mixed for the presentation time and the eye condition. We estimated the PF size for both monocular and binocular viewing at 4 different presentation times (40, 80,120, and 200 ms) with different orders of presentation in each experiment (mono-optic glasses vs. stereo glasses, utilizing the lateral masking paradigm). In each experiment we explored one variable: how changing one parameter would affect the PF size in both monocular and binocular viewing (the temporal duration, the testing order of conditions, and the spatial distance) while keeping the others constant. We found that both the monocular and binocular PF size were dynamic and were significantly affected by the presentation order, leading to reduced lateral suppression under the collinear 2λ condition. Hence, both the monocular and binocular PF size depended on the sequence of the stimulus presentation time and the testing order of the conditions. Furthermore, we found that the binocular PF size was significantly larger than the monocular PF size.

10.
Micromachines (Basel) ; 15(9)2024 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-39337753

RESUMO

Bismuth-doped aluminosilicate glass has garnered significant attention due to its unique ultra-wide luminescence properties in the near-infrared (NIR) band. Enhancing the NIR luminescence of Bi-doped glass remains challenging. To achieve Bi-doped glass with more excellent luminescent properties, a series of Bi/Cr co-doped glasses were prepared, and the optical and structural properties of the samples were observed. The results indicate that low-concentration Cr doping broadens the luminescence range of Bi/Cr co-doped glass samples. The luminescence peak of Bi in the samples is at 1230 nm, while the peak of Cr is around 804 nm. The addition of an appropriate amount of Bi2O3 can enhance the NIR luminescence of Bi and Cr in the sample, realizing the energy conversion between Bi and Cr. Bi/Cr co-doped is a novel approach for achieving broadband NIR luminescence in glass materials.

11.
Molecules ; 29(18)2024 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-39339291

RESUMO

In this research, resorbable phosphate-based glass (PBG) compositions were developed using varying modifier oxides including iron (Fe2O3), copper (CuO), and manganese (MnO2), and then processed via a rapid single-stage flame spheroidisation process to manufacture dense (i.e., solid) and highly porous microspheres. Solid (63-200 µm) and porous (100-200 µm) microspheres were produced and characterised via SEM, XRD, and EDX to investigate their surface topography, structural properties, and elemental distribution. Complementary NMR investigations revealed the formation of Q2, Q1, and Q0 phosphate species within the porous and solid microspheres, and degradation studies performed to evaluate mass loss, particle size, and pH changes over 28 days showed no significant differences among the microspheres (63-71 µm) investigated. The microspheres produced were then investigated using clinical (1.5 T) and preclinical (7 T) MRI systems to determine the R1 and R2 relaxation rates. Among the compositions investigated, manganese-based porous and solid microspheres revealed enhanced levels of R2 (9.7-10.5 s-1 for 1.5 T; 17.1-18.9 s-1 for 7 T) and R1 (3.4-3.9 s-1 for 1.5 T; 2.2-2.3 s-1 for 7 T) when compared to the copper and iron-based microsphere samples. This was suggested to be due to paramagnetic ions present in the Mn-based microspheres. It is also suggested that the porosity in the resorbable PBG porous microspheres could be further explored for loading with drugs or other biologics. This would further advance these materials as MRI theranostic agents and generate new opportunities for MRI contrast-enhancement oral-delivery applications.


Assuntos
Meios de Contraste , Vidro , Imageamento por Ressonância Magnética , Microesferas , Fosfatos , Imageamento por Ressonância Magnética/métodos , Meios de Contraste/química , Vidro/química , Fosfatos/química , Porosidade , Tamanho da Partícula , Cobre/química , Compostos Férricos/química
12.
Appl Nurs Res ; 79: 151841, 2024 10.
Artigo em Inglês | MEDLINE | ID: mdl-39256013

RESUMO

AIMS: To determine the effect of virtual reality glasses intervention on pain, vital signs, and patient satisfaction of hemodialysis patients undergoing AVF catheter puncture. DESIGN: Randomized controlled study. METHODS: The study was conducted in 60 patients receiving dialysis treatment in the HD unit of a public hospital in Turkey. The data were collected via the "Patient Identification Form", "Visual Analog Scale/VAS" and "Hemodynamics Variables Inspection Form". The patients in the experiment group watched videos through the virtual reality glasses for totally 5 minutes in average, 2 minutes before the AVF cannulation process and 3 minutes during the process. No intervention was applied to the patients in the control group other than the normal nursing interventions in the HD unit. RESULTS: In the intra-group comparisons, the 2nd and 3rd measurement average pain level scores of the patients with in the experimental group were determined to be statistically significantly lower compared to their 1st measurement (p < 0.05); the 3rd measurement average pain level scores of the control group were determined to be statistically significantly lower compared to their 1st and 2nd measurements (p < 0.05). CONCLUSIONS: It was determined that the virtual reality glasses decreased the pain that emerges during the AVF cannulation process and increased the patient satisfaction level. It is suggested that the virtual reality glasses should be used by the nurses in the HD unit since it is easily applicable in coping with pain in the patients and since it is an invasive method.


Assuntos
Satisfação do Paciente , Realidade Virtual , Humanos , Satisfação do Paciente/estatística & dados numéricos , Feminino , Masculino , Pessoa de Meia-Idade , Adulto , Idoso , Turquia , Dor/psicologia , Dor/prevenção & controle , Manejo da Dor/métodos , Cateterismo/métodos , Fístula Arteriovenosa , Diálise Renal/métodos , Óculos
13.
Artigo em Inglês | MEDLINE | ID: mdl-39235501

RESUMO

PURPOSE: The relationship between refractive error at age 1 and the risk of developing amblyopia or accommodative esotropia, and the protection offered by early glasses, is unknown. These are determined in the Early Glasses Study, a prospective, population-based, longitudinal, randomized controlled study. We report baseline findings. METHODS: Healthy children aged 12-18 months were recruited at Children's Healthcare Centres (CHCs) and received an entry orthoptic examination followed by cycloplegic retinoscopy. Children with amblyopia, strabismus, ophthalmic disease or very high refractive error were excluded. Those exceeding the AAPOS 2003 Criteria (> + 3.5D spherical equivalent (SE), > 1.5D astigmatism, > 1.5D anisometropia) were randomized into wearing glasses or not, and are followed-up by research orthoptists. Other children are followed-up by regular vision screening at CHCs and visual acuity is measured in all children at age 4. RESULTS: Parents of 865 children were called, 123 were excluded. Of 742 children enrolled, 601 underwent the entry orthoptic examination at age 14.5 ± 1.7 months. Mean SE was + 1.73 ± 1.18D, astigmatism -0.70 ± 0.44D, anisometropia 0.21D (IQR: 0-0.25). Of 62 (10.3%) children exceeding the Criteria, 52 were randomized into wearing glasses or not. Of 539 other children, 522 are followed up at CHCs. In total, 31 were excluded: 2 had strabismus and amblyopia, 7 strabismus, 2 amblyopia suspect, 1 strabismus suspect, 1 squinting during sinusitis, 4 excessive refractive error, 9 myopia, 2 ptosis, 1 oculomotor apraxia, 1 Duane syndrome, 1 congenital nystagmus. CONCLUSION: Prevalence of strabismus (10/601) was as expected, but prevalence of amblyopia (2/601) was low, suggesting that common amblyopia develops later than generally thought. KEY MESSAGES: What is known High refractive errors cause amblyopia, but no study has determined the exact relationship between the kind and size of refractive error at age 1 and the risk to develop amblyopia, and assessed the protective effect of glasses in a controlled, population-based, longitudinal study. What is new At baseline, 601 children received a full orthoptic examination followed by retinoscopy in cycloplegia at the age of 14.5 ± 1.7 months; 10.3% had high refractive error exceeding spherical equivalent > + 3.5D, > 1.5D astigmatism, > 1D oblique astigmatism or > 1.5D anisometropia. The prevalence of amblyopia was lower (0.3%) than expected, suggesting that most amblyopia develops after the first year of life. The prevalence of anisometropia, associated with amblyopia in older children, was low (0.8%).

14.
JMIR Res Protoc ; 13: e55290, 2024 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-39283663

RESUMO

BACKGROUND: Helminths are a major global health issue, impacting health, educational, and socioeconomic outcomes. Infections, often starting in childhood, are linked to anemia, malnutrition, cognitive deficit, and in chronic cases of Opisthorchis viverrini (OV), cholangiocarcinoma. The main control strategy for helminth infection is mass drug administration; however, this does not prevent reinfection. As such, prevention strategies are needed. The "Magic Glasses" is a school-based cartoon health education package that has demonstrated success in improving knowledge, attitudes, and practices (KAP) surrounding soil-transmitted helminths (STH) in China and the Philippines. This study is designed to assess the acceptability and impact of the 2 new versions of the Magic Glasses targeting STH and OV designed for the Lower Mekong audience in Cambodia, Lao People's Democratic Republic (PDR), and Thailand. OBJECTIVE: The objective of this study is to evaluate the acceptability of the "Magic Glasses Lower Mekong" and "Magic Glasses Opisthorchiasis" education packages among schoolchildren in the Lower Mekong Basin, and the impact of these education packages on students' KAP surrounding STH and OV, respectively. METHODS: Schoolchildren will be recruited into a cluster randomized controlled trial with intervention and control arms in rural schools in Cambodia, Lao PDR, and Thailand. Schoolchildren's initial acceptability of the intervention will be evaluated using an adapted questionnaire. Sustained acceptability will be assessed at 9-month follow-up through focus group discussions with students and interviews with teachers. Impact will be evaluated by KAP questionnaires on STH and OV. KAP questionnaires will be administered to children at baseline and at follow-up. Indirect impact on parents' KAP of OV and STH will be assessed through focus group discussions at follow-up. RESULTS: The trial is in progress in Lao PDR and Thailand and is expected to commence in Cambodia in January 2024. The results of the study are expected to be available 18 months from the start of recruitment. We hypothesize that participants enrolled in the intervention arm of the study will have higher KAP scores for STH and OV, compared with the participants in the control arm at follow-up. We expect that students will have initial and sustained acceptability of these intervention packages. CONCLUSIONS: This trial will examine the acceptability of the "Magic Glasses Opisthorchiasis" and "Magic Glasses Lower Mekong" interventions and provide evidence on the effectiveness of the "Magic Glasses" on KAP related to OV and STH among schoolchildren in the Lower Mekong Basin. Study results will provide insight on acceptability and impact indicators and inform a scaling up protocol for the "Magic Glasses" education packages in Cambodia, Lao PDR, and Thailand. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12623000271606; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=385315&isReview=true. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/55290.


Assuntos
Educação em Saúde , Conhecimentos, Atitudes e Prática em Saúde , Opistorquíase , Humanos , Criança , Opistorquíase/prevenção & controle , Opistorquíase/epidemiologia , Opistorquíase/psicologia , Camboja/epidemiologia , Laos/epidemiologia , Educação em Saúde/métodos , Tailândia/epidemiologia , Feminino , Masculino , Adolescente , Estudantes/psicologia , Helmintíase/prevenção & controle , Helmintíase/epidemiologia , Animais , Desenhos Animados como Assunto
15.
Adv Mater ; : e2407630, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-39219207

RESUMO

Silicate-based multicomponent glasses are of high interest for technical applications due to their tailored properties, such as an adaptable refractive index or coefficient of thermal expansion. However, the production of complex structured parts is associated with high effort, since glass components are usually shaped from high-temperature melts with subsequent mechanical or chemical postprocessing. Here for the first time the fabrication of binary and ternary multicomponent glasses using doped nanocomposites based on silica nanoparticles and photocurable metal oxide precursors as part of the binder matrix is presented. The doped nanocomposites are structured in high resolution using UV-casting and additive manufacturing techniques, such as stereolithography and two-photon lithography. Subsequently, the composites are thermally converted into transparent glass. By incorporating titanium oxide, germanium oxide, or zirconium dioxide into the silicate glass network, multicomponent glasses are fabricated with an adjustable refractive index nD between 1.4584-1.4832 and an Abbe number V of 53.85-61.13. It is further demonstrated that by incorporating 7 wt% titanium oxide, glasses with ultralow thermal expansion can be fabricated with so far unseen complexity. These novel materials enable for the first time high-precision lithographic structuring of multicomponent silica glasses with applications from optics and photonics, semiconductors as well as sensors.

16.
Biomed Mater ; 19(6)2024 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-39173660

RESUMO

Bone tissue engineering (BTE) aims to promote bone regeneration by means of the synergistic effect of biomaterials, cells, and other factors, as potential alternative to conventional treatments for bone fractures. To this aim, a composite material was developed, based on collagen type I, strontium-enriched mesoporous bioactive glasses, and hydroxyapatite nanorods as bioactive and biomimetic components. Nanostructured scaffolds were 3D printed and subsequently chemically crosslinked with genipin to improve mechanical properties and stability. The developed nanostructured system was maintained in culture until 3 weeks with a co-culture of human bone cells to provide anex vivomodel of bone microenvironment and examine the cellular crosstalk and signaling pathways through paracrine cell activities. Human osteoblasts (OBs), derived from trabecular bone, and human osteoclast precursors (OCs), isolated from buffy coat samples were involved, with OBs seeded on the scaffold and OC precursors seeded in a transwell device. When compared to the material without inorganic components, the bioactive and biomimetic scaffold positively influenced cell proliferation and cell metabolic activity, boosting alkaline phosphatase activity of OBs, and reducing OC differentiation. Thus, the bioactive and biomimetic system promoted an enhanced cellular response, highlighting its potential application in BTE.


Assuntos
Materiais Biocompatíveis , Diferenciação Celular , Proliferação de Células , Durapatita , Nanotubos , Osteoblastos , Osteoclastos , Impressão Tridimensional , Estrôncio , Engenharia Tecidual , Alicerces Teciduais , Engenharia Tecidual/métodos , Humanos , Alicerces Teciduais/química , Estrôncio/química , Osteoblastos/citologia , Osteoclastos/citologia , Osteoclastos/metabolismo , Durapatita/química , Nanotubos/química , Diferenciação Celular/efeitos dos fármacos , Materiais Biocompatíveis/química , Materiais Biocompatíveis/farmacologia , Vidro/química , Osso e Ossos/metabolismo , Osteogênese/efeitos dos fármacos , Regeneração Óssea/efeitos dos fármacos , Colágeno/química , Técnicas de Cocultura , Células Cultivadas , Fosfatase Alcalina/metabolismo , Iridoides
17.
Mater Today Bio ; 28: 101175, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39171100

RESUMO

The repair of bone defects in the elderly individuals is significantly delayed due to cellular senescence and dysfunction, which presents a challenge in clinical settings. Furthermore, there are limited effective methods available to promote bone repair in older individuals. Herein, melatonin-loaded mesoporous bioactive glasses microspheres (MTBG) were successfully prepared based on their mesoporous properties. The repair of bone defects in aged rats was significantly accelerated by enhancing mitochondrial function through the sustained release of melatonin and bioactive ions. MTBG effectively rejuvenated senescent bone marrow mesenchymal stem cells (BMSCs) by scavenging excessive reactive oxygen species (ROS), stabilizing the mitochondrial membrane potential (ΔΨm), and increasing ATP synthesis. Analysis of the underlying mechanism revealed that the formation of tunneling nanotubes (TNTs) facilitated the intercellular transfer of mitochondria, thereby resulting in the recovery of mitochondrial function. This study provides critical insights into the design of new biomaterials for the elderly individuals and the biological mechanism involved in aged bone regeneration.

18.
Behav Sci (Basel) ; 14(8)2024 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-39199124

RESUMO

The advent and progression of AR (augmented reality) technology, coupled with the emergence of AR hearing aid glasses, offer a novel opportunity for people with hearing impairments (PHI). This study aims to explore the intention of this population to employ AR hearing aid glasses as their choice of hearing aid device and the specific factors influencing their preference. This study utilized the partial least squares SEM (PLS-SEM) analytical method to create structural equation model for intentions of PHI to use AR glasses as hearing aids. Data were gathered from on-site experiences across multiple locations; a total of 189 valid questionnaires from individuals with varying degrees of hearing disabilities were used for statistical analysis. According to the data analysis results, we discovered that functionality quality, perceived interaction speed, and perceived usability significantly influence communication effectiveness. Further, communication effectiveness positively influences confidence and societal perception, and the latter has a positive impact on information. Both of these factors positively influence behavioral intention. Based on these findings, this study offers design recommendations for AR hearing aid glasses to cater to the specific needs of PHI, aiming to enhance their quality of life. Furthermore, this study provides pivotal insights for the prospective growth of this emerging industry.

19.
Sci Rep ; 14(1): 19141, 2024 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-39160180

RESUMO

In the present work, a glass system with developed composition consisting of B2O3, ZnO, Na2O and Fe2O3 samples has been investigated. Glass samples were prepared using the melt quenching method and the density of the system was measured using Archimedes' principle. Spectroscopic analysis using a gamma source and a high-purity germanium detector at four energies of 0.0595, 0.6617, 1.173, and 1.333 MeV emitted from Am-241, Cs-137, and Co-60 were used to determine the attenuation parameters of present glass composites. The sample containing 45 B2O3 + 10 Na2O + 40 ZnO + 5 Fe2O3 (coded BNZF-4) had the highest mass attenuation coefficient (MAC) value at all the energies discussed compared to the other composites. Whoever, the BNZF-1 sample had the lowest value at all ranges of energies. The transmission factors (TF, %) of the manufactured samples were calculated, at 0.0595 MeV (TF, %) values are 32.6429 and 6.4612 for samples BNZF-1 and BNZF-4, respectively. The statistical results demonstrated significantly better to increase the ZnO concentration in the sample, where the percentage of zinc oxide inside the prepared glass samples has the following direction BNZF -4 > BNZF -3 > BNZF -2 > BNZF -1. The significance of this study is that transparent, environmentally harmless glass composites with relatively high density have been prepared that can be used as shielding materials against gamma rays, especially at low energies.

20.
ACS Appl Mater Interfaces ; 16(39): 52856-52866, 2024 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-39174350

RESUMO

Integrating structural colors and conductivity into aqueous inks has the potential to revolutionize wearable electronics, providing flexibility, sustainability, and artistic appeal to electronic components. This study aims to introduce bioinspired color engineering to conductive aqueous inks. Our self-assembly approach involves mixing poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) with sulfonic acid-modified polystyrene (sPS) colloids to generate non-iridescent structural colors in the inks. This spontaneous structural coloration occurs because PEDOT:PSS and sPS colloids can self-assemble into core-shell structures and reversibly cluster into photonic aggregates of maximally random jammed packing within the aqueous environment, as demonstrated by small-angle X-ray scattering. Dissipative particle dynamics simulation confirms that the self-assembly aggregation of PEDOT:PSS chains and sPS colloids can be manipulated by the polymer-colloid interactions. Utilizing the finite-difference time-domain method, we demonstrate that the photonic aggregates of the core-shell colloids achieve close to maximum jammed packing, making them suitable for producing vivid structural colors. These versatile conductive inks offer adjustable color saturation and conductivity, with conductivity levels reaching 36 S cm-1 through the addition of polyethylene glycol oligomer, while enhanced water resistance and mechanical stability are achieved by doping with a cross-linker, poly(ethylene glycol) diglycidyl ether. With these unique features, the inks can create flexible, patterned circuits through processes like coating, writing, and dyeing on large areas, providing eco-friendly, visually appealing colors for customizable, stylish, comfortable, and wearable electronic devices.

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