A Multi-Sensing IoT System for MiC Module Monitoring during Logistics and Operation Phases.

Modular integrated construction (MiC) is now widely adopted by industry and governments. However, its fragile and delicate logistics are still a concern for impeding project performance. MiC logistic operations involve rigorous multimode transportation, loading-unloading, and stacking during storage. Such processes may induce latent and intrinsic damage to the module. This damage causes safety hazards during assembly and deteriorates the module's structural health during the building use phase. Also, additional inspection and repairs before assembly cause uncertainties and can delay the whole supply chain. Therefore, continuous monitoring of the module's structural response during MiC logistics and the building use phase is vital. An IoT-based multi-sensing system is developed, integrating an accelerometer, gyroscope, and strain sensors to measure the module's structural response. The compact, portable, wireless sensing devices are designed to be easily installed on modules during the logistics and building use phases. The system is tested and calibrated to ensure its accuracy and efficiency. Then, a detailed field experiment is demonstrated to assess the damage, safety, and structural health during MiC logistic operations. The demonstrated damage assessment methods highlight the application for decision-makers to identify the module's structural condition before it arrives on site and proactively avoid any supply chain disruption. The developed sensing system is directly helpful for the industry in monitoring MiC logistics and module structural health during the use phase. The system enables the researchers to investigate and improve logistic strategies and module design by accessing detailed insights into the dynamics of MiC logistic operations.

Expert Consensus on Standardized Construction of Integrated Outpatient Clinic for Cervical Cancer Prevention and Control in Hubei Provincial Grassroots Maternal and Child Health Hospitals / 肿瘤防治研究

Cervical cancer is a malignant tumor that can be effectively controlled and eventually eliminated through etiological prevention, pathogenic prevention, and clinical prevention. In China, some problems exist in comprehensive prevention and control system for cervical cancer, such as uneven development, insufficient capacity building, and scattered institutions. In 2022, the Hubei Provincial Government launched a province-wide project to provide free cervical cancer screening for 12.67 million women aged 35-64 from 2022 to 2024. It is a historic opportunity and of great significance to fully utilize the scale and team advantages of this full-coverage cervical cancer screening, build integrated outpatient clinic for cervical cancer prevention in grassroots maternal and child health hospitals, and implement standardized construction and management. The expert group of the Cervical Disease Prevention and Control Professional Committee of Hubei Maternal and Child Health Association formulated this consensus based on the latest progress and the actual situation in Hubei. The consensus elucidated the general requirements, HPV vaccination outpatient construction standards and workflow, cervical cancer screening outpatient construction standards and workflow, colposcopy outpatient construction standards and workflow, precancerous lesion treatment outpatient construction standards and workflow, the follow-up after treatment of precancerous lesions, public education, etc. This consensus is suitable for guiding the standardized construction and management of integrated outpatient clinics for cervical cancer prevention and control in grassroots (county, district) maternal and child health hospitals in Hubei province.

Digital inspection techniques of modular integrated construction.

As a new construction form, modular integrated construction (MiC) can effectively improve the construction quality and productivity, especially for the construction of high-density and high-rise buildings. However, the current MiC quality inspection relies on manual inspection, which is inefficient and unreliable. Systematic research on digital inspection techniques (DITs) is fragmented and unable to fully realize the potential of the MiC industry. This study aims to explore the current state of DIT applications in MiC and to summarize the knowledge in the field through an analysis of 248 relevant literatures. Accordingly, this study combines bibliometric analysis, and a system engineering evaluation approach based on 3D structures (time, knowledge, and logic) to provide an overview of the current state of DIT development. The overview includes the application of DITs from a whole life cycle perspective, the DIT knowledge structure, specific DIT applications, as well as current challenges and future prospects.

Integrated Construction Improving Electrochemical Performance of Stretchable Supercapacitors Based on Ant-Nest Amphiphilic Gel Electrolytes.

Aqueous integrated stretchable supercapacitors (ISSCs) have attracted extensive attention due to the intrinsic safety in future wearable electronics. However, aqueous ISSCs usually suffer from low energy density and poor dynamic deformation stability owing to the conventional hydrogel electrolytes' narrow electrochemical stability window (ESW) and dissatisfied interface bonding. Herein, an ant-nest amphiphilic polyurethane hydro/organogel electrolyte (sAPUGE) with a wide ESW (≈2.2 V) and superb self-adhesion is prepared by electrospinning, which interacts with carbon-based stretchable electrodes for the construction of flame-retardant PU-based sAPUGE-ISSC. Benefitting from the synergistic effect of chemical bonding and mechanical meshing between the electrode and gel electrolyte interface, as-assembled sAPUGE-ISSC delivers a high energy density of 13.7 mWh cm-3 (at a power density of 0.126 W cm-3 ) and outstanding dynamic deformation stability (98.3% capacitance retention after 500 stretching cycles under 100% strain). This unique hydro/organogel electrolyte provides a pathway toward the next generation of wearable energy products in modern electronics.

Integrated construction of silkworm cocoon-inspired 3D scaffold for improving cell manufacture and cryopreservation.

Although cellular therapy holds enormous promise in treating intractable diseases, its application potential has been significantly hampered due to the scarcity of reliable and consistent cell sources. Therefore, a high-efficiency strategy that improves cell production and storage is desperately needed. Herein, we develop a versatile 3D bioinspired scaffold (Cryosilk) for improving scalable cell manufacture and cryopreservation. A bottom-up fabrication technique integrating electrospinning, in situ surface functionalization and freeze-shaping was explored to construct Cryosilk with biomimetic features and functions of silkworm cocoons. Cryosilk is composed of a core-shell heterostructure with silk fibroin/poly alanine fiber core and silk sericin shell, generating a 3D cocoon-mimicking fibrous structure. Importantly, Cryosilk possesses improved thermal conductivity and ice crystal resistance capability, thus enabling to cryopreserve biological samples with minimal cryodamage. Furthermore, Cryosilk not only promotes cell adhesion and growth, but achieves rapid and uniform rewarming process, which provides high cryopreservation efficacy for immune cells and stem cells. Particularly, Cryosilk can maintain cell viability and biofunctions of stem cell-scaffold constructs after freeze-thawing, which can be directly implanted to promote wound healing. Thus, Cryosilk offers unprecedented efficacy in cell manufacture and cryopreservation, which provides sufficient and high-quality precious cells and tissue engineered scaffolds for cellular therapy.

Boosting Oxygen Reduction via Integrated Construction and Synergistic Catalysis of Porous Platinum Alloy and Defective Graphitic Carbon.

Integrated fabrication through the strong interaction between catalyst and carrier is crucial to realize efficient oxygen electrocatalysis for fuel cells. We report herein a porous Pt-rich alloy encapsulated by graphitic carbon via integration engineering, where a synergistic catalysis between ternary PtCuCo alloy and graphitic Co-N-C results in the optimized reaction pathway and improved oxygen reduction reaction (ORR) performance. The hybrid catalyst PtCuCo@Co-N-C delivers a mass activity of 1.14 A mgPt -1 at 0.9 V vs. RHE and a peak power density of 960 mW cm-2 in the full-cell assessment, outperforming commercial Pt/C catalyst (0.12 A mgPt -1 and 780 mW cm-2 ). Experimental results combined with theoretical simulations suggest that the mutual assistance between porous Pt alloy and Co-N-C accounts for the enhanced catalytic performance. Such integrated engineering concept is significant for strengthening the anti-corrosion capabilities and improving the ORR performance of Pt-based catalysts.

Critical factors for successful implementation of just-in-time concept in modular integrated construction: A systematic review and meta-analysis.

Modular integrated construction (MiC) is a revolutionary construction method. However, the logistics management of MiC has always been a major barrier to the wider adoption of MiC. Nonetheless, this challenge can be tackled by the application of lean techniques, namely, just-in-time (JIT). Numerous studies have identified and evaluated the critical factors (CFs) required to implement JIT; however, there is no consensus among the previous studies on these CFs and their level of importance. Therefore, this research, for the first time, provides a systematic review and meta-analysis of these CFs. The systematic review identifies 42 CFs. To further provide a synthesis analysis of previous studies, a meta-analysis approach is used. This analysis is conducted on the identified CFs to evaluate their importance level and hence rank them. The results indicate that all the 42 CFs are important for applying JIT, of which seven are highly significant for successfully implementing JIT in MiC. Although the ranking obtained by meta-analysis is much more reliable than that provided in the individual studies, however, there is still a high heterogeneity in the results, which depicts the uncertain nature of the construction field. Therefore, sub-group analysis is conducted to investigate this heterogeneity and uncover the hidden patterns in the literature. This is achieved by studying the influence of predictive factors (moderators) on the importance level of CFs. This analysis shows that the economy of a country and the type of project executed are influential factors. The results further indicate that developing economies, in contrast to advanced economies, should pay more attention to three CFs. Also, the results show that seven CFs are much more important in MiC projects than the other project types. This research work is highly beneficial for theory development and for practitioners by identification of significant CFs that warrant management dedication to best apply JIT. Researchers, in particular, can consider the recommendations given here for implementing future meta-analysis studies.

Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors.

A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.